The international standard ISO/IEC 17025 [1] clause 7.7.2 with regards to ensuring the validity of results, requires a laboratory to participate in proficiency testing (PT) and/or to participate in interlaboratory comparisons (ILCs) other than PT. However, no guidance as to what these other ILCs might be, or indeed how they might compare in relation to PT, is provided. This leaflet aims to outline other ILCs available, pointing out some of the limitations as compared to PT.&nbsp;There are three major types of ILCs in which a group of laboratories analyses identical portions from a homogeneous, stable test sample, with each type being characterized by its intended purpose [2,3]:<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Eurachem_Interlaboratory_comparisons_other_than_proficiency_testing_2_d9263807fb.jpg" alt="Eurachem: Interlaboratory comparisons other than proficiency testing" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Eurachem_Interlaboratory_comparisons_other_than_proficiency_testing_2_d9263807fb.jpg 245w," sizes="100vw" width="1507" height="607">A key point is that PT is an ILC that is designed to specifically evaluate the performance of participants, providing them with an infrastructure to monitor and assess the validity of their results. This is not the key purpose of the two other ILCs, and thus depending on their intended purpose they have a number of limitations that laboratories need to be aware of when using them rather than PT. Only proficiency testing should have been conducted in full compliance to the competency standard ISO/IEC 17043 [4].&nbsp;<h4>Evaluation of measurement procedure performance&nbsp;</h4>These ILCs, are designed to assess how a particular measurement procedure performs and whether it is fit for its intended purpose. These ILCs are often referred to as a ‘method performance study’ or a ‘collaborative study’ [2]. Some limitations of using such ILCs for monitoring laboratory performance as an alternative to PT are:&nbsp;<ul><li>All participants use the same measurement procedure i.e. the measurement procedure that is being validated. Unless the measurement procedure is being routinely used by the participating laboratory such an ILC will not assess the routine performance of the laboratory using their own routine measurement procedure. Nor does it enable them to compare their performance with other laboratories using alternative measurement procedures.&nbsp;</li><li>The measurement procedure is likely to be new, so participants may not have established stable procedures and quality control, so performance may not reflect routine use.&nbsp;</li><li>The report from such an ILC would not provide information on the performance of the participant, if the statistical model used makes the assumption that all laboratories perform with equal variability.</li><li>The design of the study may require the participants to assess multiple samples and/or to undertake multiple replicate analysis on the test materials. This may not be representative of the routine measurements or tests undertaken by the laboratory.&nbsp;</li><li>The conclusion of the ILC might be that the measurement procedure being assessed is not valid.&nbsp;</li></ul><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Eurachem_Interlaboratory_comparisons_other_than_proficiency_testing_3_a53ecd2f5d.jpg" alt="Eurachem: Interlaboratory comparisons other than proficiency testing" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Eurachem_Interlaboratory_comparisons_other_than_proficiency_testing_3_a53ecd2f5d.jpg 157w," sizes="100vw" width="570" height="566"><h4>Characterisation of candidate reference materials&nbsp;</h4>These are ILCs that assign a property value to a candidate reference material, usually with a stated measurement uncertainty. These are often referred to as a ‘material certification study’ [2]. Limitations of using such ILCs as an alternative to PT are:&nbsp;<ul><li>The analysis of the candidate reference material is likely to require additional care in exercising the routine measurement procedure, such as substantially more replication, and/or may require quite different reporting formats (e.g. all valid replicates instead of a mean result). Thus, such an ILC will not necessarily provide an evaluation of the performance of the laboratory based on the routine use of their measurement procedures.&nbsp;</li><li>The report from such an ILC may include the results from the participating laboratories but would not provide information on the performance of each laboratory.&nbsp;</li><li>Participating laboratories may be required to assess multiple samples and/or to undertake multiple replicate analysis on the candidate reference materials. Thus this may not be representative of the routine measurements or tests undertaken by the laboratory.&nbsp;</li></ul><h4>Other ILCs&nbsp;</h4>Some other ILCs, whilst not being conducted in full compliance of the requirements of ISO/IEC 17043, may be designed to evaluate participant performance. These would include small ILCs as defined by EA‑2/21 [5] or split sample ILCs i.e. where a portion of a single sample is sent to two or three laboratories. Whilst these ILCs are specifically designed to evaluate participant performance, they may not provide a comprehensive comparison that a PT might provide. In such cases the laboratory needs to evaluate carefully the competence of the organization managing the ILC and the suitability of the service externally provided (ISO/IEC 17025 clause 6.6).

Interlaboratory comparisons other than proficiency testing

Our Library never stops expanding. What are the most recent contributions to LabRulezICPMS Library in the week of 29th June 2026? Check out new documents from the field of spectroscopy/spectrometry and related techniques!<blockquote>👉 <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/library">SEARCH THE LARGEST REPOSITORY OF DOCUMENTS ABOUT SPECTROSCOPY/SPECTROMETRY RELATED TECHNIQUES</a></blockquote><blockquote>👉 Need info about different analytical techniques? Peek into <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/library">LabRulezLCMS</a> or <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library">LabRulezGCMS</a> libraries.</blockquote>This week we bring you application notes by Agilent Technologies and Thermo Fisher Scientific and brochure by Shimadzu!<h3>1. Agilent Technologies: Analysis of High Purity Titanium Using an <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/library?mainauthorItems=10&amp;search=9500">Agilent 9500 ICP-QQQ</a></h3>Ensuring purity and performance of titanium materials used in high-tech industries&nbsp;<ul><li>Application note</li><li><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/labrulez-bucket-strapi-h3hsga3/an_high_purity_titanium_9500_icp_qqq_5994_9024en_agilent_56ab5e943b.pdf">Full PDF for download</a></li></ul><h5>Importance of high-purity titanium and the role of ICP-QQQ&nbsp;</h5>High-purity titanium (Ti) is a critical material in high-tech industries such as semiconductor manufacturing and aerospace engineering. In semiconductor applications, Ti is widely used as a sputtering target for thin-film deposition, where even trace levels of impurities can negatively affect film uniformity, electrical properties, and device reliability. In aerospace applications, Ti is valued for its high strength-to-weight ratio and corrosion resistance, making it an ideal material for engine components and structural parts. However, any impurities can compromise the mechanical integrity and diminish the long-term performance of components, especially when operating under extreme conditions.Ensuring the reliability and functionality of Ti in these demanding environments requires precise quantification of trace impurities in the raw material. Triple quadrupole Inductively Coupled Plasma Mass Spectrometry (ICP-QQQ) provides robust suppression of spectral interferences and ultra-low detection limits (DLs), enabling accurate determination of impurities at or below the 1 mg/kg (ppm) level in the solid. This level of sensitivity is particularly important for quality control (QC) of high-purity Ti, where conventional techniques such as XRF, ICP-OES, and GD-MS lack the sensitivity and DLs.&nbsp;For unrivalled interference reduction using reactive cell gases, Agilent ICP-QQQ instruments include two unit mass (1 u) quadrupole mass filters, Q1 and Q2.1 Q1 is positioned before the collision/reaction cell (CRC) to select which ions enter the cell for reaction with the cell gas. Q2 filters ions that exit the cell before they pass to the detector. This tandem mass spectrometer (MS/MS) operation allows for unmatched control of reaction chemistry in the CRC, making the technique useful for handling intense spectral interferences, including polyatomic, doubly charged ion (M++), isobaric, and peak overlap interferences.&nbsp;Using the newly developed <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/library?mainauthorItems=10&amp;search=9500">Agilent 9500 Triple Quadrupole ICP-MS</a> featuring a Dual-Cell System (DCS) CRC and equipped with an optional m-lens, analysts can confidently analyze Ti matrix samples and verify material purity over extended measurement periods. The m-lens is designed with an optimized geometry that minimizes background signals from easily ionized elements that can deposit on interface components during long runs. This feature enables the instrument to maintain high-power, matrix-tolerant plasma conditions while achieving ultralow background equivalent concentrations (BECs), which is critical for ppt-level impurity analysis. Operating the DCS with a suitable cell gas effectively controls spectral interferences from Ti-based species (Ti²+ and TiO+ ) that impact elements like sodium (Na), magnesium (Mg), copper (Cu), and zinc (Zn). Together with the m‑lens, this approach ensures accurate measurement of trace elemental impurities, enabling compliance within stringent industry standards. The effectiveness of the m‑lens in minimizing background signals and enabling ppt‑level impurity analysis under robust plasma conditions has also been demonstrated in high-matrix applications using ICP‑QQQ.2, 3 In addition to interference control, the 9500 ICP-QQQ system’s robustness and reproducibility make it well suited for routine analysis in both research and production settings. This capability supports the continued advancement of high-tech applications that rely on ultra-clean titanium.In this study, a 200 ppm Ti solution prepared from a high-purity Ti powder was used to represent a typical sample encountered in advanced material analysis. The performance of the 9500 ICP-QQQ for quantifying trace impurities, including Na, Mg, Cu, and Zn, in a high Ti matrix was assessed through spike-recovery experiments and long-term stability tests.<h4>Conclusion&nbsp;</h4>This study demonstrated the effectiveness of the Agilent 9500 ICP-QQQ with m-lens for the ultra-trace analysis of impurity metals in high-purity titanium. By applying optimized reaction gas conditions and mass-shift techniques, spectral interferences from Ti-based species such as Ti²+ and TiO+ were successfully mitigated, enabling accurate quantification of elements like Mg, Cu, and Zn.&nbsp;The method achieved limits of quantification in the sub-ppm range for the undiluted Ti digestion solution and maintained stable ISTD signals over extended measurement periods. Spike recovery tests confirmed high accuracy and reproducibility, with most elements showing recoveries within ±10% and RSDs below 3%.&nbsp;These results confirm that the 9500 ICP-QQQ is a robust and reliable tool for quality control of high-purity Ti, supporting its critical applications in semiconductor and aerospace industries where impurity levels must be strictly controlled.<h3>2. Shimadzu: Scanning Probe Microscope /Atomic Force Microscope SPM-9700HT Plus</h3><ul><li>Brochure</li><li><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/labrulez-bucket-strapi-h3hsga3/c147_e021_4c550d3be3.pdf">Full PDF for download</a></li></ul>The Shimadzu SPM-9700HT Plus is a high-throughput scanning probe microscope (SPM) / atomic force microscope (AFM) designed for three-dimensional surface imaging and nanoscale characterization of material properties across a broad range of scientific and industrial applications. The system combines high-resolution topographical imaging with multiple AFM measurement modes, including contact, dynamic, phase, lateral force, force modulation, and force-curve measurements, while optional modules extend its capabilities to techniques such as Kelvin probe force microscopy (KPFM), magnetic force microscopy (MFM), conductive AFM, piezoresponse force microscopy (PFM), and scanning tunneling microscopy (STM). A wide selection of interchangeable scanners, environmental accessories, optical microscope units, and specialized sample holders enables the instrument to be configured for diverse analytical requirements.A major focus of the brochure is the system's emphasis on automation and ease of use through Shimadzu's Analytical Intelligence technology. Features such as Observation Navigation, NanoAssist, and the optional Cantilever Master automate instrument setup, cantilever installation, optimization of imaging parameters, and measurement workflows, allowing operators with varying levels of experience to acquire high-quality, reproducible AFM data. The redesigned control electronics and scanning system also enable high-throughput imaging and rapid physical property mapping while maintaining nanoscale resolution. In addition, the head-slide mechanism simplifies sample exchange without removing the cantilever, increasing productivity during routine measurements.Beyond surface topography, the SPM-9700HT Plus provides extensive quantitative analysis capabilities through integrated software for roughness measurements, particle analysis, cross-sectional profiling, and morphological characterization. Optional Nano 3D Mapping Fast technology extends the instrument to nanoscale mechanical property measurements by performing force-curve mapping, allowing localized evaluation of adhesion, Young's modulus, and other mechanical properties of thin films, polymers, biomaterials, and soft samples. The optional Particle Analysis Software further enables automated extraction, classification, statistical evaluation, and export of particle size and morphology data for large datasets.The brochure demonstrates the versatility of the platform through numerous application examples spanning electronics, semiconductor devices, magnetic materials, life sciences, industrial materials, batteries, polymers, nanomaterials, food science, and chemistry. Representative studies include magnetic domain imaging, organic thin-film transistor characterization, collagen and DNA visualization, live-cell imaging, lithium-ion battery electrode and separator analysis, photocatalyst surface potential measurements, polymer phase imaging, cellulose nanofiber characterization, and beer yeast morphology. Together, these examples highlight the Shimadzu SPM-9700HT Plus as a comprehensive AFM platform capable of combining rapid imaging, advanced nanoscale property mapping, and automated data analysis for both research and routine industrial quality control.<h3>3. Thermo Fisher Scientific: Enhancing Monoclonal Antibody Yield and Quality Through Automated Multi-Component Feedback Control Loops Using the MarqMetrix All-In-One Process Raman Analyzer</h3><ul><li>Application note</li><li><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/labrulez-bucket-strapi-h3hsga3/enhancing_monoclonal_antibody_an1506_en_bba763e865.pdf">Full PDF for download</a></li></ul>The application of Raman spectroscopy for real-time monitoring and control of bioreactors marks a significant advancement in bioprocessing technology. Over the past decade, its adoption has enabled tighter control of critical process parameters (CPPs), offering early indicators of process performance to ensure consistency and improve product quality. Raman spectroscopy leverages the unique vibrational signatures of molecules, allowing for highly specific detection even in complex biological matrices. This enables simultaneous, real-time monitoring of multiple CPPs, including nutrient concentrations, metabolic by-products, and cell density. As a result, users gain deep, real-time insights into cellular metabolism and can implement more dynamic, adaptive feeding strategies based on metabolic network understanding.&nbsp;Previous studies have demonstrated the negative impact of high lactate on cell health and quantity and quality of titer produced.² In this study, we demonstrate the successful implementation of process Raman analyzer for simultaneous multi-component feedback control of glucose and lactate in a bioreactor. By continuously monitoring both analytes, the feedback control loop dynamically maintained a constant total carbon concentration (glucose + lactate) at a setpoint of 2 g/L.&nbsp;This advanced carbon-source-based control strategy ensured that cellular metabolic demands were met while promoting lactate consumption toward the end of the run. As a result, lactate accumulation was significantly reduced, leading to substantial improvements in titer yield, product quality, and cell viability compared to standard bolus feeding strategies (Figure 2).The outcomes of this work underscore the <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/products/2233">Thermo Scientific™ MarqMetrix™ All-In-One Process Raman Analyzer </a>as a key Process Analytical Technology (PAT) tool-enabling real-time, multi-analyte control for any biomanufacturer seeking to engage in intelligent, automated biomanufacturing.<h4>Conclusion&nbsp;</h4><h5>1. Unmatched Real-Time Control Capability:&nbsp;</h5>Maintaining a constant total carbon concentration (glucose + lactate) of 2 g/L in dynamic bioreactor environments demands precise, simultaneous analyte monitoring. The MarqMetrix All-In-One Process Raman Analyzer delivers near real-time, high-fidelity data every two minutes, empowering advanced control strategies that are simply not feasible with conventional technologies. This makes it an indispensable PAT tool for modern bioprocessing.&nbsp;<h5>2. Proven Impact on Product Yield and Quality:&nbsp;</h5>The Raman-enabled carbon control strategy resulted in a &gt;10% increase in titer and a reduction in glycation by 83% and 66% compared to continuous and fed-batch glucose control, respectively. These outcomes underscore the analyzer’s transformative impact on both product quantity and quality.&nbsp;<h5>3. Versatile Automation Across Bioprocesses:&nbsp;</h5>All three bioreactor runs—each employing distinct control logics (Table 2)—were successfully managed through automated feedback using the process Raman analyzer. Its flexible design, including easily swappable probes, supports seamless adaptation to other critical metabolites such as amino acids, making it a universal solution for bioprocess control.&nbsp;<h5>4. Foundation for Intelligent Manufacturing:&nbsp;</h5>With its real-time, data-rich insights and seamless integration into automated systems, the MarqMetrix All-InOne analyzer is not just a monitoring tool; it is a cornerstone technology for intelligent, AI-driven biomanufacturing. It enables consistent, high-quality production while reducing time, cost, and variability.

News from LabRulezICPMS Library - Week 27, 2026

Scientists from CEITEC Brno University of Technology led by Markéta Kaiser have achieved a globally unique breakthrough in coral research. Using the live microCT method, they were able, for the first time ever, to observe the growth of living marine corals in real time and reveal the processes behind the formation of their calcium carbonate skeletons, which had previously remained hidden beneath the surface. The results of the international study, published in the prestigious journal Science Advances, show how corals grow, regenerate, and respond to stress and competing organisms.The <a target="_blank" rel="noopener noreferrer" href="https://www.science.org/doi/10.1126/sciadv.aee3183">study</a> was carried out through a collaboration between researchers from Brno, Vienna, and several other international institutions. A key role was played by the X-ray Micro and Nano Computed Tomography Laboratory (CTLAB) at CEITEC BUT, where all the crucial data and three-dimensional coral models were produced. CEITEC also shares both the first and corresponding authorship of the study.“Thanks to live microCT, we were able, for the first time, to observe what happens beneath the surface of a coral skeleton,” explains Markéta Kaiser from CTLAB at CEITEC BUT. “For example, we witnessed situations where a coral, after being attacked by algae, completely halted its normal growth and began building a protective wall around the threatened area. Once the danger had passed, it was able to resume its original growth pattern.”<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/CEITEC_Zivi_korali_jezdili_vlakem_z_Vidne_do_Brna_Vedci_diky_nim_odhalili_jejich_tajny_zivot_540e183e84.jpeg" alt="CEITEC BUT/Jakub Rozboud: Live Corals Traveled by Train from Vienna to Brno. Scientists Uncovered Their Secret Life: Markéta Kaiser, CTLAB CEITEC at CEITEC BUT." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_CEITEC_Zivi_korali_jezdili_vlakem_z_Vidne_do_Brna_Vedci_diky_nim_odhalili_jejich_tajny_zivot_540e183e84.jpeg 235w," sizes="100vw" width="1600" height="1067">The scientists successfully captured coral growth both vertically and horizontally, the formation of protective barriers against competing organisms, and regeneration mechanisms following damage.The research was exceptionally demanding from a technological standpoint. The team had to develop a special system that enabled living corals to be safely scanned directly in seawater. The coral colonies regularly traveled by train from Vienna to Brno for measurements and, after several hours, were transported back to professional aquarium systems in Vienna.“At first, it seemed like a somewhat crazy idea. No one knew whether living corals could withstand repeated scanning,” says Kaiser. “Gradually, however, we found that they survived, continued to grow, and provided us with unique data.”<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/CEITEC_Zivi_korali_jezdili_vlakem_z_Vidne_do_Brna_Vedci_diky_nim_odhalili_jejich_tajny_zivot_2_fcbb29a4f6.jpeg" alt="CEITEC BUT/Jakub Rozboud: Live Corals Traveled by Train from Vienna to Brno. Scientists Uncovered Their Secret Life: Markéta Kaiser is placing a coral sample into CT for scanning." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_CEITEC_Zivi_korali_jezdili_vlakem_z_Vidne_do_Brna_Vedci_diky_nim_odhalili_jejich_tajny_zivot_2_fcbb29a4f6.jpeg 235w," sizes="100vw" width="1600" height="1067">The original concept for the project came from developmental biologist Igor Adameyko of the Medical University of Vienna, who proposed combining marine biology with advanced imaging technologies more commonly used in engineering and technical fields.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/CEITEC_Zivi_korali_jezdili_vlakem_z_Vidne_do_Brna_Vedci_diky_nim_odhalili_jejich_tajny_zivot_3_8c5f376f41.jpeg" alt="CEITEC BUT/Markéta Kaiser: Live Corals Traveled by Train from Vienna to Brno. Scientists Uncovered Their Secret Life: Corals CT - 1." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_CEITEC_Zivi_korali_jezdili_vlakem_z_Vidne_do_Brna_Vedci_diky_nim_odhalili_jejich_tajny_zivot_3_8c5f376f41.jpeg 228w," sizes="100vw" width="1600" height="1096">The findings of the Brno researchers have already attracted the attention of experts in Okinawa, Japan, who specialize in coral reef research. They plan to use the live microCT method to study the effects of light, photosynthesis, and environmental changes on coral growth.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/CEITEC_Zivi_korali_jezdili_vlakem_z_Vidne_do_Brna_Vedci_diky_nim_odhalili_jejich_tajny_zivot_4_445c1cc3b7.jpeg" alt="CEITEC BUT/Markéta Kaiser: Live Corals Traveled by Train from Vienna to Brno. Scientists Uncovered Their Secret Life:Corals CT - 2." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_CEITEC_Zivi_korali_jezdili_vlakem_z_Vidne_do_Brna_Vedci_diky_nim_odhalili_jejich_tajny_zivot_4_445c1cc3b7.jpeg 245w," sizes="100vw" width="1600" height="988">According to the researchers, the project demonstrates the importance of interdisciplinary collaboration between engineering and biological sciences. The research could contribute not only to the study and conservation of coral reefs, but also to fields such as paleontology and materials science.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/CEITEC_Zivi_korali_jezdili_vlakem_z_Vidne_do_Brna_Vedci_diky_nim_odhalili_jejich_tajny_zivot_5_514ee9c974.jpg" alt="CEITEC BUT/Markéta Kaiser: Live Corals Traveled by Train from Vienna to Brno. Scientists Uncovered Their Secret Life: Corals CT - 3." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_CEITEC_Zivi_korali_jezdili_vlakem_z_Vidne_do_Brna_Vedci_diky_nim_odhalili_jejich_tajny_zivot_5_514ee9c974.jpg 143w," sizes="100vw" width="1600" height="1750"><blockquote><h4>Original Article</h4><h4><a target="_blank" rel="noopener noreferrer" href="https://www.science.org/doi/10.1126/sciadv.aee3183">Coral growth, retraction, defense, and regenerative strategies revealed by live microCT</a></h4>Karina Araslanova, Marketa Kaiser, Anton Fetisov, Diana Gavrik, Tomas Zikmund, Daniel Abed-Navandi, Karel Katovský, Jozef Kaiser, Igor AdameykoSci. Adv., 2026, 12, eaee3183<a target="_blank" rel="noopener noreferrer" href="https://doi.org/10.1126/sciadv.aee3183">https://doi.org/10.1126/sciadv.aee3183</a><h6>licenced under <a target="_blank" rel="noopener noreferrer" href="https://creativecommons.org/licenses/by/4.0/">CC-BY 4.0</a></h6></blockquote><h4>Abstract</h4>Understanding how corals build and remodel their skeletons is key to explaining reef resilience, yet most insights come from static imaging. Using longitudinal live microCT, we tracked the same coral colonies over weeks to months at micrometer resolution. Coral skeleton formation is not a uniform accretion process but a dynamic integration of multiple programs, including vertical and horizontal patterned growth, previously undescribed defensive wall-building against competitors, exploratory edge behavior with reversible expansions and retractions, and skeletal regeneration favoring rapid, imprecise yet effective matrix expansion. Time-resolved imaging links colony-scale growth to microscale events, showing that all modes depend on balances between fusion of skeletal microparticles and layered matrix deposition, guided by tissue prepatterning. Beyond corals, this framework generalizes to studying skeletal dynamics across diverse biomineralizing organisms.

Live Corals Traveled by Train from Vienna to Brno. Scientists Uncovered Their Secret Life 

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Since its establishment in 2011, CEITEC has quickly developed into a cutting-edge infrastructure for research which performs highly alongside the best institutes in Europe. Among the main priorities of CEITEC are the promotion of a motivating and dynamic international scientific environment, the provision of state-of-the-art research infrastructure, and the policy of open communication and equal opportunities.

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Eurachem is a European network promoting international traceability of chemical measurements and good analytical practice. It provides expert guidance, supports method validation, uncertainty evaluation, proficiency testing, and facilitates discussion on technical and policy issues in analytical quality.

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UV-Vis measurements you want to make do not always fall into the realm of a liquid in a standard cuvette.
When this is the case, the ability to add an accessory to the sample compartment or in the case of the Cary 3500, swap out a sampling Module, is key to increasing your measurement capabilities. This presentation will explore various options for expanding measurement capabilities, especially the Cary 3500 with the recently introduced Flexible Module.
<blockquote>
Presenter: Mark Fisher, PhD (Application Engineer, Molecular Spectroscopy, Agilent Technologies, Inc.)
</blockquote>
<blockquote>
Mark, an Application Scientist for Agilent Technologies, has over 35 years of experience in molecular spectroscopy. He has held roles in Agilent&#39;s UV-Vis-NIR, fluorescence, and atomic absorption product portfolios. In addition to identifying industry trends and new business needs, Mark&#39;s responsibilities include application development, pre and post-sales support, as well as acting as a customer advocate for new product and technology opportunities. Mark received his doctorate in analytical chemistry from the University of Nebraska-Lincoln.
</blockquote>

agilent Technologies: Expanding Your UV-Vis Measurement Capabilities through the use of Accessories

Expanding Your UV-Vis Measurement Capabilities through the use of Accessories

Explore various options for expanding measurement capabilities, especially the Cary 3500 with the recently introduced Flexible Module.

Expanding Your UV-Vis Measurement Capabilities

This is a three-week workshop series on environmental applications with Agilent ICPMS systems.
Week 1: we will start the workshop with basic theories of ICPMS, typical workflow of the most common EPA methods, as well as a discussion in sample preparations.
<blockquote>
Presenter: L. Craig Jones (ICP-MS Application Scientist, Agilent Technologies, Inc.)
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<blockquote>
Craig has been with Agilent for over 15 years as an ICP-MS applications scientist. He has been involved with multiple type of applications for ICP-MS, including environmental, pharmaceutical, semiconductor, geologic, and clinical analyses, to name a few. Previous to Agilent he worked in an environmental lab performing analysis and supervising both the inorganic and organic sections of the laboratory. In his spare time, Craig enjoys volunteering at the local marine science center, mountain biking, hiking, and relaxing at the beach. Craig obtained a Bachelor of Science degree in chemistry from Fort Lewis College in Durango, CO.
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<blockquote>
Presenter: Yan Cheung (PhDApplication Scientist, Agilent Technologies, Inc.)
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<blockquote>
Yan received her Ph.D. in Analytical Chemistry from Indiana University Bloomington. She joined Agilent Technologies as an Application Scientist in the Life Science and Chemical Analysis team in April 2020. Yan has extensive experience in operating and method development in ICP-MS. Yan also has years of experience working in the oil and gas industry.
</blockquote>

Agilent Technologies: Getting excellent results without the complexity! Introduction to EPA 200.8, EPA 6020 methods workflow in ICP-MS

Getting excellent results without the complexity! Introduction to EPA 200.8, EPA 6020 methods workflow in ICP-MS

Environmental applications with Agilent ICPMS systems. Basic theories of ICPMS, typical workflow of the most common EPA methods.

EPA 200.8, EPA 6020 methods workflow in ICP-MS

This is a three-week workshop series on environmental applications with Agilent ICPMS systems.
Week 2: will be focused on Agilent ICPMS software and hardware demos. We will show you the ins and outs of the instrument, a typical environmental analysis work flow, as well as tips and tricks on preventative maintenances.
<blockquote>
Presenter: L. Craig Jones (ICP-MS Application Scientist, Agilent Technologies, Inc.)
</blockquote>
<blockquote>
Craig has been with Agilent for over 15 years as an ICP-MS applications scientist. He has been involved with multiple type of applications for ICP-MS, including environmental, pharmaceutical, semiconductor, geologic, and clinical analyses, to name a few. Previous to Agilent he worked in an environmental lab performing analysis and supervising both the inorganic and organic sections of the laboratory. In his spare time, Craig enjoys volunteering at the local marine science center, mountain biking, hiking, and relaxing at the beach. Craig obtained a Bachelor of Science degree in chemistry from Fort Lewis College in Durango, CO.
</blockquote>
<blockquote>
Presenter: Yan Cheung (PhDApplication Scientist, Agilent Technologies, Inc.)
</blockquote>
<blockquote>
Yan received her Ph.D. in Analytical Chemistry from Indiana University Bloomington. She joined Agilent Technologies as an Application Scientist in the Life Science and Chemical Analysis team in April 2020. Yan has extensive experience in operating and method development in ICP-MS. Yan also has years of experience working in the oil and gas industry.
</blockquote>

Agilent Technologies: See it to believe it! Bring it All Together, an ICP-MS software and hardware live demo

See it to believe it! Bring it All Together, an ICP-MS software and hardware live demo

Environmental applications with Agilent ICPMS systems. Agilent ICPMS software and hardware demos.

Agilent ICPMS software and hardware demos

This webinar will introduce the innovative use of Spatially Offset Raman Spectroscopy (SORS) for Raw Material Verification.
SORS provides an optimal solution for see-through verification, effectively penetrating challenging containers like amber glass and paper bags. The session will spotlight two instruments - Vaya, a handheld system, and Rapid, a portable system - both of which excel in assessing challenging materials. These devices offer a high-throughput, reliable, and convenient solution for RMV, aligning with the strict compliance requirements of the biopharmaceutical industry.
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Presenter: Yanqia Wang, PhD (Application Engineer, Molecular Spectroscopy, Agilent Technologies, Inc.)
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Dr. Yanqia Wang started working for Agilent Technologies Inc. as a FTIR application Engineer in 2013, providing pre-&amp;post-sale application support. The products he covers from Bench-top FTIR microscopes to various Mobile FTIR spectrometers. Dr. Wang received his PhD of analytical chemistry from Duke University in 2004, doing dynamic IR spectroscopy research. Then he joined Fitzpatrick Center for Photonics at Duke University, doing Tissue Raman spectrometer instrumentation. Since 2007, Dr. Wang worked for Avery Dennison Corp. as a spectroscopist, providing molecular analytical support to the research &amp; development.
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Presenter: Scott Melis, PhD (Application Scientist, Agilent Technologies, Inc.)
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Scott Melis has a PHD in Physics from Georgetown University in Washington, DC and started with Agilent in 2021 as a Molecular Spectroscopy Application Scientist. In his graduate work, Scott studied nanoparticle formation and growth for a variety of applications. Projects that he worked with include developing processes to deposit and characterize semiconducting molecular nano-cocrystals for use in optoelectronic devices as well as controlling polymer nanoparticle size through rapid mixing conditions.
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Agilent Technologies: Identification of Raw Materials by a Handheld Instrument in Amber Glass, Paper Bags, and Other Challenging Containers

Identification of Raw Materials by a Handheld Instrument in Amber Glass, Paper Bags, and Other Challenging Containers

Innovative use of Spatially Offset Raman Spectroscopy (SORS) for Raw Material Verification.

Identification of Raw Materials by a Handheld Instrument

X-ray Absorption Spectroscopy (XAS) is a powerful and versatile technique that fits into the larger landscape of material characterization techniques by providing unique, element-specific insights into the local atomic structure, electronic properties, and bonding interactions of materials.
It complements and enhances the information obtained from other characterization methods, contributing to a more comprehensive understanding of materials. 
In this session, we will discuss the utility of XAS and how newly developed lab-scale instrumentation enables its practical use as an everyday tool for materials characterization. Come see real world applications of laboratory XAS. 
Key Learning Objectives:
<ul>
<li>Introduction to X-ray Absorption Spectroscopy and its unique capabilities for materials characterization.
</li>
<li>Detailed look into example applications of laboratory XAS. 
</li>
<li>Overview of new lab-scale XAS instrumentation.
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<li>Understanding the process of conducting a laboratory XAS measurement, including a real-time measurement demonstration.
</li>
</ul>
Who Should Attend:
<ul>
<li>Research Scientists from Universities or Industries that routinely perform materials characterization.
</li>
<li>Materials Characterization Lab Managers and Users interested in understanding new techniques.
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<li>Those interested in element-specific, non-destructive material analysis.
</li>
</ul>
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Presenter: Dr. Devon Mortensen (CEO, easyXAFS)
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Presenter: Dr. William Holden (CTO, easyXAFS)
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Presenter: Dr. Zachary Lebens-Higgins (Testing and R&amp;D Manager, easyXAFS)
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Presenter: Catherine Dold (Health &amp; Environment Writer, C&amp;EN Media Group)
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C&EN: Lab X-ray Absorption: A New Dimension for Materials Characterization

Lab X-ray Absorption: A New Dimension for Materials Characterization

The utility of XAS and how newly developed lab-scale instrumentation enables its practical use as an everyday tool for materials characterization.

Lab X-ray Absorption for Materials Characterization

Choosing the right LIMS is a challenge, but it can be accomplished with sufficient research and strong compatibility between your organization’s needs and the functionality of the software.
Once companies have selected the right LIMS, they will need to embark on the next stage of their journey – implementation. It is imperative that your implementation project is successful and efficient, driven by the strategic partnership and common goals that you and your vendor have established.
In this webinar, we will discuss how to achieve a successful laboratory software installation:
<ul>
<li>Consider resources - a successful project needs key stakeholder involvement. What&#39;s usually expected from a customer? Who should be involved, and how much time will they need to commit?
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<li>What are you looking to solve? You will have thought about this while selecting your solution, but you must revisit this to ensure you stay on track and understand the true scope of your project.
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<li>Key LIMS project management considerations - Keep things simple, know your scope, work in phases. We&#39;ll cover all the common pitfalls of lab software projects and how to avoid them.
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<li>Looking ahead. Your LIMS project doesn&#39;t stop when you go live. How can you ensure ongoing success through the life of your LIMS?
</li>
</ul>
By attending this presentation, you will:
<ul>
<li>learn how to elevate your laboratory with a successful LIMS implementation
</li>
<li>understand the important aspects of the implementation journey
</li>
<li>see how a successful implementation can ensure ongoing success for your organization
</li>
</ul>
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Presenter: Anand Radhakrishnan (Services Manager – Digital Science Solutions, Thermo Fisher Scientific)
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Anand Radhakrishnan is the Services Manager for the Digital Solutions division at Thermo Fisher Scientific. Anand has an extensive background in customer relations and implementation strategies among life sciences and R&amp;D organizations. He joined Thermo Fisher in 2018 as a Senior Global Customer Success Manager, ensuring implementations of LIMS across customers, and transitioned to a Services Manager leading the Digital Solutions technical implementation team in September 2020. In his current role, he leads a team of specialists as they support technical implementation of LIMS in pharmaceutical, diagnostic, and quality control laboratories to execute the customer’s R&amp;D digital transformation strategy. Anand has a Ph.D. in Biochemistry and Microbiology from the Max Planck Institute for Biophysical Chemistry, an M.Sc in Molecular Biology from the International Max Planck Research School, and a Bachelor’s Degree in Biochemistry from the University of Malaya.
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Separation Science: Elevate your lab: How to manage a successful LIMS implementation

Elevate your lab: How to manage a successful LIMS implementation

How to achieve a successful laboratory software installation.

How to manage a successful LIMS implementation

Join us for a webinar that delves into the crucial aspects of plant-based foods – their nutritional composition, safety, and the innovative technology that enables accurate analysis. As the demand for plant-based foods continues to surge, ensuring their nutritional excellence and safety is paramount.
In this webinar, we will explore the world of plant-based foods and the challenges associated with their analysis of nutritional content for safety. From addressing rising concerns about animal cruelty to promoting environmental sustainability and enhanced health benefits, the momentum behind plant-based diets is undeniable. However, with these benefits come responsibilities to accurately assess nutritional and toxic elements to meet regulatory standards.
Our expert panel will guide you through the application of ICP-MS for plant-based foods. Uncover the NexION 2200 ICP-MS system, a cutting-edge technology designed to analyse a wide range of elemental concentrations, from parts per million (ppm) to parts per trillion (ppt) levels.
<ul>
<li>Understand the challenges surrounding accurate nutritional labelling and safety assessment in the plant-based food industry.
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<li>Discover how ICP-MS plays a pivotal role in monitoring nutritional and toxic elements in plant-based raw materials and finished products.
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<li>Learn about the latest advancements in elemental analysis technology and its applications in ensuring compliance with quality control criteria and regulatory standards.
</li>
</ul>
Uncover the benefits of the NexION 2200, the latest ICP-MS analysis technology on the market
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Presenter: Liyan Xing (Senior Application Scientist, PerkinElmer)
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Dr. Liyan Xing is a Senior Application Scientist for ICP-MS at PerkinElmer with experience in elemental and isotope analysis using ICP-MS/MC-ICP-MS and/or hyphenated technologies, such as HPLC, GC, and laser ablation. She holds a PhD in Analytical Chemistry and an MSc in Organic Chemistry specializing in the synthesis and characterisation of supramolecules. She has done post-doc research on the catalytic mechanisms in hydrogen fuel cells. Liyan is a national committee member of CSASS and the editor of the Newsletter since 2019. She has published research on speciation analysis using HPLC-ICP-MS, isotope analysis using MC-ICP-MS/LA-ICP-MS, the oxide formation mechanisms in ICP-MS, Pt catalytic mechanisms in hydrogen fuel cells, and template synthesis of supramolecules and helices.
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Presenter: Aaron Hineman (Inorganic Product Line Leader, PerkinElmer)
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Aaron Hineman is currently the Inorganic Product Line Leader for the Americas. Prior to this position, he was a Senior Field Application Scientist with PerkinElmer. Aaron has a strong background in inorganic analytical chemistry including demonstrated hands-on expertise in state-of-the-art ICP-MS and ICP-OES instrumentation, hyphenated speciation using chromatography coupled to ICP-MS, working in 21 CFR Part 11 compliant laboratories for elemental impurity analysis, and various microwave, acid and fusion sample preparation techniques. Prior to joining PerkinElmer, he spent 10 years in environmental and geochemical laboratories developing analytical methodology and laboratory systems. His interests outside of work include snowboarding/skiing, obstacle races, biking, and running.
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New Food: Plant-Based Food Revolution: leveraging ICP-MS for quality assurance and nutritional insights

Plant-Based Food Revolution: leveraging ICP-MS for quality assurance and nutritional insights

The world of plant-based foods and the challenges associated with their analysis of nutritional content for safety.

Plant-Based Food Revolution: leveraging ICP-MS

Dr. Andrew “Dru” Namanja, Principal Research Scientist at AbbVie, will explore the potency ranking methods involving both qualitative single-point ligand concentration (Q Score) and quantitative binding affinity (KD), and how the combined utility can be used successfully to drive a Fragment-Based Drug Discovery (FBDD) campaign.
<h4>Intro</h4>
Protein-based nuclear magnetic resonance (NMR) is an established gold-standard biophysical tool in early-stage drug discovery that provides atomic-resolution insights into protein-ligand interactions in solution. It ensures accurate confirmation of screening hits and drug leads by reducing the number of false positives and thereby saving resources and time in fast-paced setting with a high target attrition rate
<h4>Overview</h4>
The various applications of protein-based NMR in early-stage drug Discovery will be discussed, including classifying ligand mode-of-action (MoA), hit identification and confirmation from typical small molecule screening modalities such as DNA-encoded libraries (DEL), high-throughput screening (HTS), virtual library screening (VLS), and fragment-based screening (FBS).
<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Mestrelab_Efficiently_Driving_Protein_based_NMR_Fragment_Screening_and_Lead_Discovery_2_4f692f8fc1/Mestrelab-Efficiently-Driving-Protein-based-NMR-Fragment-Screening-and-Lead-Discovery-2.jpg" alt="Mestrelab: Efficiently Driving Protein-based NMR Fragment Screening and Lead Discovery"/>
Protein-based NMR also enables the tracking of structure-activity relationships (SAR) of weak binding fragments as they are elaborated to potent leads. This webinar will explore the potency ranking methods involving both qualitative single-point ligand concentration (Q Score) and quantitative binding affinity (KD), and how the combined utility can be used successfully to drive a Fragment-based Drug Discovery (FBDD) campaign. Furthermore, automated data analysis workflows will be discussed that employ spectral fingerprint analyses such as PCA (principal component analysis) and ECHOS (easy comparability of higher order structure) in conjunction with the standard chemical shift perturbation (CSP)-based method. This can significantly accelerate FBDD when using protein-detected NMR methods.
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Presenter: Dr. Andrew “Dru” Namanja (Principal Research Scientist, AbbVie)
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With over 20 years of experience in pharma and academia, Dru applies NMR methods to protein-ligand interactions to drive early-stage drug discovery research at AbbVie. His research interests include streamlining NMR workflows and applying AI/ML tools to advance FBDD. Dru holds a Biochemistry Ph.D. from the University of Notre Dame.
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Mestrelab: Efficiently Driving Protein-based NMR Fragment Screening and Lead Discovery

Efficiently Driving Protein-based NMR Fragment Screening and Lead Discovery

We will explore the potency ranking methods and how the combined utility can be used successfully to drive a Fragment-Based Drug Discovery (FBDD) campaign.

Protein-based NMR Fragment Screening and Lead Discovery

Optimization of costly NMR spectrometer acquisition time while maintaining short turnaround times are of peculiar importance for analytical services, usually dealing with large number of samples. For structural analysis, a significant step was achieved with the use of Non-Uniform Sampling (NUS) for 2D acquisition on a routine basis. Now, with the introduction of a tool like SmartDriveNMR, further optimization in full automation is possible to find to find the optimal acquisition parameters for the desired spectral quality.
Selecting the appropriate NMR acquisition parameters to ensure adequate spectral quality while limiting the acquisition time has always been a challenge in NMR, requiring training and experience. Non-Uniform Sampling was a significant milestone to limit acquisition time, yet it also even complicated parameter selections. Without prior scouting analysis, even advanced user may fail, ending up with low quality data and/or wasting spectrometer time.
To try to tackle these challenges, Evotec ID Lyon has implemented SmartDriveNMR for its routine structural analysis workflows. This webinar will present this use case, towards automated, failsafe on-the-fly optimization of NMR acquisition for structural analysis.
<h3>Key Learning Topics</h3>
<ul>
<li>Implementation of SmartDriveNMR as the primary tool for structural analysis in an industrial Analytical Service</li>
<li>Customization and optimization for the user’s needs</li>
<li>Feedback after more than 1 year of routine use, benefits and shortcomings</li>
</ul>
<h5>Who should attend</h5>
This webinar will be of interest to people who own or work with AVANCE Neo but also AVANCE 3 for liquid state NMR with any kind of sample changer.
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Presenter: Dr. Valentin Poirier (Senior Research Scientist at Evotec (ID) Lyon)
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Valentin Poirier holds a PhD in chemistry from the University of Rennes, focused on organometallic catalysis and polymers. He then joined the pharmaceutical industry and pivoted to the analytical field, focusing on NMR and MS. After several years managing the analytical platform of a CRO he joined Evotec ID Lyon in 2021 as the head of the local Analytical Chemistry Department. 
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Presenter: Dr. Bjoern Heitmann (Product Manager for SmartDriveNMR at Bruker BioSpin)
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Studied physics at both undergraduate and PhD level, with his postgraduate studies focused around protein NMR. Since then, Bjoern has undertaken multiple postdoc positions before joining Bruker BioSpin in the R&amp;D department. Bjoern has been with Bruker since 2006 and currently heads the Software R&amp;D department.
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Bruker: Streamlining NMR Spectrometer Usage, a Use-Case of SmartDriveNMR for Pharmaceutical Industry

Streamlining NMR Spectrometer Usage, a Use-Case of SmartDriveNMR for Pharmaceutical Industry

This webinar will present this use case, towards automated, failsafe on-the-fly optimization of NMR acquisition for structural analysis.

NMR Spectrometer Usage: SmartDriveNMR for Pharmaceuticals

X-ray Photoelectron Spectroscopy (XPS) is a powerful tool used for characterizing materials and analyzing surfaces, playing a significant role in developing materials for the green energy sector.
Join us for an informative session on Shimadzu’s Digital Classrooms to explore how XPS contributes to innovation solutions towards sustainability.
Herein, discover valuable insights that XPS offers into the chemical composition and surface properties of materials used in next-generation solar cell materials and advanced battery components. XPS, a non-destructive technique, offers highly precise and detailed information about the elemental composition and chemical states of these material surfaces.
Our session will also showcase the capabilities of the AXIS Supra+ photoelectron spectrometer. Get to experience first-hand how XPS enhances our understanding of surface chemistry and electronic structure, leading to optimization in material performance, efficiency, and durability.
As we find ourselves in an era of growing environmental concerns, XPS plays a crucial role in the development of sustainable energy technologies. Join us as we explore how XPS enables scientists and engineers to create a cleaner, greener future for the next generations to come.
Learning Objectives:
<ul>
<li>Importance of surface analysis for green energy sector materials
</li>
<li>Applications of XPS
</li>
<li>Importance of high sensitivity &amp; high energry resolution XPS
</li>
<li>Capabilities of AXIS Supra+
</li>
</ul>
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Presenter: Dr. Adam Roberts (Marketing Manager, Kratos Analytical Ltd)
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Dr. Roberts joined Kratos Analytical as an Applications Specialist in the Surface Analysis business in 1998. With over 25 years of experience in applications of surface analysis for materials characterization Adam has great depth of knowledge of the subject. This scientific experience has been developed in parallel with commercial sales and marketing of the scientific instruments supplied by Kratos Analytical.
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Presenter: Dr. Simon Hutton (Sales Manager, Kratos Analytical Ltd)
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Dr. Hutton is currently Sales Manager for surface analysis products at Kratos Analytical. He started as an applications specialist and still has a &#39;hands-on&#39; approach to instrument sales, acquiring applications data when time allows. Simon has many years experience of XPS and surface analysis.
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Presenter: Tan Teck Beng (Product Manager (Scientific), Shimadzu (Asia Pacific))
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Tan Teck Beng is the Product Manager for Scientific Instrument in Shimadzu Asia Pacific. He has been providing application support for OES, XRF, XRD, EPMA, SPM and ESCA for the past 20 years. He has conducted numerous Application Seminars and Workshops on Materials Characterization/Failure Analysis/Restriction of Hazardous Substances in countries supported by Shimadzu Asia Pacific. The countries where he has conducted include Malaysia, Indonesia, Thailand, India, Philippines, Myanmar, Vietnam and Singapore. He is currently providing Application and Technical Support for Shimadzu Scientific Instruments for more than 200 companies in Asia Pacific Region utilizing shimadzu scientific instruments. He has an MSc degree in Materials Science from the National University of Singapore.
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Shimadzu: X-ray Photoelectron Spectroscopy: Powering the Future of Renewable Energy