<div><p><strong>In 2025, two outstanding young female researchers, Drs. Filipa Oliveira and Stella Gonsales, both originally from outside the Czech Republic, received prestigious JUNIOR STAR grants from the Czech Science Foundation (GAČR). JUNIOR STAR enables early career researchers to establish their own independent research groups and significantly advance their scientific careers. Their projects reflect cutting-edge research in materials science and sustainable chemistry, highlighting the international reach and welcoming research environment at UCT Prague.</strong></p><p><strong>Dr. Stella Gonsales is also a&nbsp;laureate of the Dagmar Procházková Fund, which supports promising scientific projects in sustainable and advanced organic chemistry. Another recipient of this grant is Dr.&nbsp;Anna Valunchene, whose research complements UCT Prague’s&nbsp;sustainability goals. This dual funding underlines Stella’s&nbsp;remarkable achievements and the wide scope of innovative research at UCT Prague.</strong></p><p><strong>Both Filipa and Stella are actively looking for motivated students and researchers to join their teams, offering a&nbsp;unique opportunity to work at the forefront of science in a&nbsp;vibrant and supportive environment.</strong></p></div><div><h3><strong>Interview with Filipa Oliveira: Pioneering tubular MXenes for supercapacitor energy storage</strong></h3><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/VSCHT_Praha_V_prestizni_soutezi_GACR_uspely_dve_zahranicni_vedkyne_z_VSCHT_2_da6e538579.jpeg" alt="VŠCHT Prague: JUNIOR STAR Grants at UCT Prague: Two talented women from abroad driving innovation in science: Filipa Oliveira" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_VSCHT_Praha_V_prestizni_soutezi_GACR_uspely_dve_zahranicni_vedkyne_z_VSCHT_2_da6e538579.jpeg 235w," sizes="100vw" width="1500" height="999"></p><h5><strong>Congratulations on receiving the JUNIOR STAR grant. What does this achievement mean for you and how will it influence your next steps?</strong></h5><p>Thank you. It’s&nbsp;a huge achievement to receive this prestigious grant. It gives me the opportunity to establish my own research group here at UCT Prague. The JUNIOR STAR program supports talented young scientists in building their teams and accessing resources. This means I&nbsp;now have the support to focus fully on my research about tubular MXenes and their application in supercapacitors.</p><h5><strong>Why are tubular MXenes so innovative for energy storage?</strong></h5><p>MXenes are a family of 2D materials with a layered, accordion-like structure and known for their excellent electrical conductivity. Our innovation is to produce them with a tubular morphology, combining the high conductivity and redox activity in superior ion-transport tubular architectures. Their open, hollow structure increases surface area, ion diffusion and charge transport. This could translate to faster, more efficient supercapacitors, critical for sustainable energy technologies.</p><h5><strong>How did your scientific interest lead you to this field?</strong></h5><p>Global challenges around green energy made me focus on materials that can improve energy storage. MXenes stood out because changes in the composition and structure can significantly change their properties. I&nbsp;was curious about how tuning different metallic elements in a&nbsp;tubular morphology can impact how MXenes perform and how to optimize them for practical applications.</p><h5><strong>What challenges have you encountered?</strong></h5><p>One major challenge is their stability: MXenes oxidize quickly which deteriorates performance. Another challenge is understanding how synthesis conditions of both MXenes and their precursors (MAX phases) must be adapted to create and preserve tubular morphologies since their synthesis mechanisms differ from conventional MXenes. Additionally, effectively communicating the project in the funding proposal to show to reviewers why I&nbsp;should obtain this funding was also a&nbsp;challenge, but thanks to mentorship and collaboration, I&nbsp;overcame these hurdles.</p><h5><strong>What motivates you most about working at UCT Prague?</strong></h5><p>The support from colleagues and the excellent technical infrastructure make it a&nbsp;great place to work. Also, being a&nbsp;former member of Professor Sofer’s&nbsp;leading group in 2D&nbsp;materials is inspiring and led me to this achievement.</p><h5><strong>How do&nbsp;you see your professional development going in the future?</strong></h5><p>The grant will help me build my own team, acquire equipment, and develop collaborations. My long-term vision is to contribute significantly to sustainable energy solutions and scientific progress both locally and internationally.</p><h5><strong>You are looking for new team members. What kind of students or scientists do&nbsp;you need?</strong></h5><p>We are currently welcoming enthusiastic master's&nbsp;students, PhD candidates, and postdocs who are passionate about materials science and eager to explore new frontiers in MXenes and energy storage. If you love curiosity-driven research and want to be part of a&nbsp;growing international team, we encourage you to join us.</p><h3><strong>Interview with Stella Gonsales: Catalysis as a&nbsp;key to polymer recycling</strong></h3><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/VSCHT_Praha_V_prestizni_soutezi_GACR_uspely_dve_zahranicni_vedkyne_z_VSCHT_3_3d0ded6274.jpeg" alt="VŠCHT Prague: JUNIOR STAR Grants at UCT Prague: Two talented women from abroad driving innovation in science: Stella Gonsales" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_VSCHT_Praha_V_prestizni_soutezi_GACR_uspely_dve_zahranicni_vedkyne_z_VSCHT_3_3d0ded6274.jpeg 233w," sizes="100vw" width="1499" height="1000"></p><h5><strong>Congratulations on your JUNIOR STAR grant and also being awarded the Dagmar Procházková Fund. What does receiving both mean to you and how will they shape your work?</strong></h5><p>Thank you. Both grants are hugely important. The JUNIOR STAR grant allows me to expand my group and resources for research into catalytic recycling of polymers, while the Dagmar Procházková Fund supports complementary projects such as synthesizing new biodegradable polymers. Together, they help tackle the plastic waste problem from multiple scientific angles.</p><h5><strong>Could you explain your research in layperson’s&nbsp;terms?</strong></h5><p>Most plastics have strong carbon-carbon bonds. We insert more cleavable double bonds into polymers that can be broken down by catalytic reactions called olefin metathesis, making recycling on a&nbsp;molecular level more feasible.</p><h5><strong>What makes the JUNIOR STAR grant particularly important for your research and career development?</strong></h5><p>The JUNIOR STAR grant is a&nbsp;prestigious and highly competitive funding opportunity aimed at excellent early-career scientists within eight years of completing a&nbsp;Ph.D. It provides up to 25&nbsp;million CZK over five years, allowing recipients to establish independent research groups and pursue innovative scientific topics. This grant is crucial for building a&nbsp;solid foundation, acquiring necessary equipment, and recruiting talented team members, enabling the pursuit of ambitious projects that can significantly contribute to both the Czech scientific community and global challenges.</p><h5><strong>What collaborations support your research?</strong></h5><p>The collaboration between UCT Prague and the Institute of Organic Chemistry and Biochemistry (IOCB) of the Czech Academy of Sciences primarily provides financial and technical support. The cooperation helps with funding, access to advanced equipment, and operational resources needed for running research projects.</p><h5><strong>What advice would you give young scientists aiming to succeed?</strong></h5><p>I&nbsp;encourage thinking outside the box and combining diverse knowledge you acquire during your career to address complex problems that are exciting and relevant to you.</p><h5><strong>Your laboratory bears the name of Otto Wichterle and was ceremonially opened in the presence of Professor Kamil Wichterle. How does Wichterle’s&nbsp;legacy inspire you personally?</strong></h5><p>Wichterle’<s>’</s>s&nbsp;innovative spirit motivates me to push creative boundaries and pursue novel solutions in sustainable chemistry.</p><h5><strong>What are your visions for the future?</strong></h5><p>I&nbsp;aim to build a&nbsp;research group that advances sustainable polymer recycling, contributing to environmental responsibility and the circular economy.</p><h5><strong>You are recruiting people for your team. What skills do&nbsp;they need to have?</strong></h5><p>We are looking for talented Ph.D. students and postdocs experienced in air-sensitive catalysis techniques. If you want to contribute to transformative research in sustainable chemistry and join a&nbsp;dynamic team, this is a&nbsp;great opportunity.</p></div>

JUNIOR STAR Grants at UCT Prague: Two talented women from abroad driving innovation in science

<p><strong>The clean laboratories of the CEITEC Nano research infrastructure at CEITEC Brno University of Technology house a four-meter-tall TITAN transmission electron microscope for researching materials at the atomic level. This scientific device underwent two significant upgrades this year, entailing the addition of two state-of-the-art technologies: an electromagnetic lens aberration corrector for scanning transmission electron microscopy and an electron energy loss spectrometer equipped with cameras featuring today's most sensitive sensors. Thanks to these upgrades, TITAN has become a state-of-the-art device that can only be found in a few of the world's most advanced laboratories in this configuration.</strong></p><p><strong>The TITAN Themis microscope </strong>was manufactured in 2015 by FEI (now Thermo Fisher Scientific) and has been in use at CEITEC BUT since 2016. At the time of its acquisition, it was one of<strong> the most powerful commercially available electron microscopes</strong>; however, it lacked a corrector for optical defects in the lenses that form the narrow electron beam scanning the sample. This meant limited resolution and a lower ability to analyze the chemical composition and physical properties of materials at the atomic level.</p><p><i>"The latest generation S-CORR aberration corrector allows the electron beam to be focused to a size up to twice smaller than an atom, while also providing a higher electron current. This has led to a significant increase in the resolution and analytical capabilities of the microscope,"</i> explains <strong>Jan Michalička</strong>, guarantor of the TITAN microscope. "<i>Thanks to the new corrector, our microscope achieves the world's highest standard in resolution, specifically less than 50 picometers at an acceleration voltage of 300 keV." </i>For better understanding, he adds a comparison: <i>"Imagine the ratio of the size of a golf ball to that of planet Earth. That is exactly the ratio of an atom measuring 100 pm to a golf ball."</i> Thanks to this resolution, scientists are not only able to image individual atoms, but also to determine their chemical nature through further analysis. This is of fundamental importance, for example, for the development of new catalysts for a more environmentally friendly chemical industry.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/CEITEC_Upgrade_transmisniho_elektronoveho_mikroskopu_TITAN_zaradil_CEITEC_mezi_elitni_laboratore_8ebd8d7245.jpg" alt="CEITEC/CEITEC BUT archive: Upgrade of TITAN transmission electron microscope ranks CEITEC among elite laboratories: Differences in resolution before and after the installation of the aberration corrector." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_CEITEC_Upgrade_transmisniho_elektronoveho_mikroskopu_TITAN_zaradil_CEITEC_mezi_elitni_laboratore_8ebd8d7245.jpg 245w," sizes="100vw" width="1600" height="904"></p><p>The new corrector also allows the microscope to achieve high resolution even with low-energy electrons. This is crucial for studying highly sensitive materials such as graphene and other two-dimensional structures, which would be damaged by a stronger electron beam. <i>"Electrons interact strongly with the sample and can damage it at the atomic level, for example, by changing its structure and chemical composition. With the new corrector, we can achieve atomic resolution even at the lowest acceleration voltage of 60 keV, allowing us to study even very sensitive materials in a virtually unchanged state," </i>says Jan Michalička.</p><h4><strong>The additional installation of a corrector at the CEITEC laboratory is unique worldwide</strong></h4><p><strong>Correctors of optical defects in electromagnetic lenses are an exceptional technology</strong> that has completely changed the world of electron microscopy. For a long time, they were considered technically impossible, and the absence of correctors essentially prevented research into the structure and properties of materials at the atomic level. It was not until the 1990s that a group of four scientists – Harald Rose, Max Haider, Knut Urban, and Ondřej Křivánek – succeeded in implementing this technology, for which they received the prestigious Kavli Prize in 2020. <i>“Correctors basically consist of a pair of complex lenses, each containing a series of magnetic multipoles. In the case of the correctors invented by the first three scientists mentioned above, defects are removed by two hexapole lenses. Our new corrector is based on the same concept,”</i> adds Jan Michalička.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/CEITEC_Upgrade_transmisniho_elektronoveho_mikroskopu_TITAN_zaradil_CEITEC_mezi_elitni_laboratore_2_c7e74d8554.jpeg" alt="CEITEC/CEITEC BUT archive: Upgrade of TITAN transmission electron microscope ranks CEITEC among elite laboratories: Delivered aberration corrector prior to installation, with the TITAN microscope in the background." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_CEITEC_Upgrade_transmisniho_elektronoveho_mikroskopu_TITAN_zaradil_CEITEC_mezi_elitni_laboratore_2_c7e74d8554.jpeg 117w," sizes="100vw" width="1600" height="2133"></p><p>The additional installation of a corrector is <strong>unique </strong>in itself nowadays. Similarly complex technologies are usually installed during the manufacture of microscopes in the factory, in this case in the Netherlands. However, in Brno, the microscope was successfully upgraded with a corrector under the limited conditions of the laboratory. The installation of the corrector took about four months and required the dismantling of a large part of the microscope. <i>"With this installation, we basically went back to the time when the four scientists mentioned above placed their prototype corrector on an older microscope, thus improving its performance,"</i> says Jan Michalička with a smile, adding that the most difficult part was the precise adjustment of the corrector and the entire optics of the microscope in order to achieve top parameters. <i>"Even though most things are now controlled by computers, there are only a few people in the world who can install and tune a corrector to the highest level of accuracy. We are therefore extremely pleased to have had such experts at our disposal here."</i></p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/CEITEC_Upgrade_transmisniho_elektronoveho_mikroskopu_TITAN_zaradil_CEITEC_mezi_elitni_laboratore_4_b2cf95fb5c.jpeg" alt="CEITEC/CEITEC BUT archive: Upgrade of TITAN transmission electron microscope ranks CEITEC among elite laboratories: Installation of the aberration corrector – removal of the condenser." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_CEITEC_Upgrade_transmisniho_elektronoveho_mikroskopu_TITAN_zaradil_CEITEC_mezi_elitni_laboratore_4_b2cf95fb5c.jpeg 117w," sizes="100vw" width="1600" height="2133"></p><h4><strong>New spectrometer will enable scientists to see more</strong></h4><p>The second and equally important upgrade to the TITAN microscope is the installation of <strong>the latest generation GIF Continuum HR electron energy loss spectrometer by Gatan</strong>. This is an approximately two-meter-long device installed horizontally under the microscope, whose main component is a magnetic prism that separates the electron beam according to their energy losses. The spectra of these losses provide enormous information about the sample, principally at the atomic level, as they are characteristic of the given state of the atoms, such as the valence arrangement of their electron shell. In combination with the new corrector, the spectra can be used to analyze the chemical bonds, arrangement in the crystal lattice, or the entire range of physical properties of atomic nanostructures down to the level of individual atoms.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/CEITEC_Upgrade_transmisniho_elektronoveho_mikroskopu_TITAN_zaradil_CEITEC_mezi_elitni_laboratore_8_fdab871ef5.jpeg" alt="CEITEC/CEITEC BUT archive: Upgrade of TITAN transmission electron microscope ranks CEITEC among elite laboratories: Installation of the spectrometer beneath the microscope, magnetic prism." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_CEITEC_Upgrade_transmisniho_elektronoveho_mikroskopu_TITAN_zaradil_CEITEC_mezi_elitni_laboratore_8_fdab871ef5.jpeg 117w," sizes="100vw" width="1600" height="2133"></p><p>An essential part of the spectrometer are the <strong>state-of-the-art K3 and Stela cameras</strong>, which can directly detect and count individual electrons. At the same time, these cameras are extremely fast and their sensors capture data without noise. <i>"These features of our cameras are key to measuring sensitive or dynamically changing samples and allow us to obtain information that was previously invisible to electron microscopes,"</i> says Jan Michalička.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/CEITEC_Upgrade_transmisniho_elektronoveho_mikroskopu_TITAN_zaradil_CEITEC_mezi_elitni_laboratore_9_d8b87903f2.jpeg" alt="CEITEC/CEITEC BUT archive: Upgrade of TITAN transmission electron microscope ranks CEITEC among elite laboratories: Installed high-performance spectrometer cameras." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_CEITEC_Upgrade_transmisniho_elektronoveho_mikroskopu_TITAN_zaradil_CEITEC_mezi_elitni_laboratore_9_d8b87903f2.jpeg 117w," sizes="100vw" width="1600" height="2133"></p><p>Last but not least, the spectrometer will open up completely new possibilities for measuring the magnetic properties of atomic structures. The new spectrometer will also be used for such experiments within the project TERAFIT, which financed this upgrade, and which focuses on research into materials for ultra-high capacity, speed, and energy efficiency in information technology. <i>"The device is fully prepared for advanced experiments and the use of modern software tools, including artificial intelligence,"</i> adds <strong>Vojtěch Uhlíř</strong>, head of the <i>Nanomagnetism and Spintronics</i> research group at CEITEC BUT and one of the TERAFIT project investigators, highlighting the advantages of the spectrometer.</p><p>Together with the corrector, the spectrometer represents a breakthrough in the analysis of material properties, and according to Jan Michalička, CEITEC now has one of the most powerful microscopes available. <i>“In modern materials science, for example, in the development of magnetic memories, quantum materials, or 2D structures, it is necessary to see not only atoms, but also their behaviour in real time, including magnetic states. And it is this spectrometer that pushes the boundaries of what we can see and analyze.</i>” Michal Urbánek, head of the CEITEC Nano laboratories and coordinator of the large research infrastructure <a target="_blank" rel="noopener noreferrer" href="https://www.czechnanolab.cz/"><strong>CzechNanoLab</strong></a>, agrees with him, adding that the device can now contribute to scientific knowledge on a global scale. <i>“Thanks to its integration into the large CzechNanoLab research infrastructure, this state-of-the-art microscope is accessible not only to scientists from CEITEC, but also to other institutions in the Czech Republic and abroad.”</i></p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/CEITEC_Upgrade_transmisniho_elektronoveho_mikroskopu_TITAN_zaradil_CEITEC_mezi_elitni_laboratore_10_7a2b57cc6d.jpeg" alt="CEITEC/CEITEC BUT archive: Upgrade of TITAN transmission electron microscope ranks CEITEC among elite laboratories: Final configuration of the TITAN microscope after installation of the aberration corrector and spectrometer." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_CEITEC_Upgrade_transmisniho_elektronoveho_mikroskopu_TITAN_zaradil_CEITEC_mezi_elitni_laboratore_10_7a2b57cc6d.jpeg 117w," sizes="100vw" width="1600" height="2133"></p><blockquote><p>Do you want to know more? Read the<strong> </strong><a target="_blank" rel="noopener noreferrer" href="https://www.ceitec.eu/upgrade-of-titan-transmission-electron-microscope-ranks-ceitec-among-elite-laboratories-expert-version/t11696?secret=40ab0267-ec7e-11f0-8f5d-2ed9ab825d4b"><strong>expert version</strong></a><strong> </strong>of this article.</p></blockquote>

Upgrade of TITAN transmission electron microscope ranks CEITEC among elite laboratories

<p><strong>Scientists at IOCB Prague are uncovering new details of gene transcription. They have identified a previously unknown molecular mechanism by which the transcription of genetic information from deoxyribonucleic acid (DNA) into ribonucleic acid (RNA) can be initiated. The researchers focused on a specific class of molecules known as alarmones, which are found in cells across a wide range of organisms and whose levels often increase under conditions of cellular stress. The results were published in the prestigious scientific journal </strong><i><strong>Nature Chemical Biology</strong></i><strong>.</strong></p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/UOCHB_Vyzkum_z_UOCHB_odhaluje_dosud_nepoznany_zpusob_prepisu_geneticke_informace_bc2bfffa6c.jpg" alt="IOCB Prague/Tomáš Belloň: Research from IOCB Prague reveals a previously unknown mechanism of genetic transcription: Dr. Hana Cahová, head of the Chemical Biology of Nucleic Acids research group." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_UOCHB_Vyzkum_z_UOCHB_odhaluje_dosud_nepoznany_zpusob_prepisu_geneticke_informace_bc2bfffa6c.jpg 234w," sizes="100vw" width="2000" height="1335"></p><div><p>Molecules of ribonucleic acid can carry a variety of chemical modifications at one end, known as caps. In eukaryotic organisms, including human cells, the best-known cap plays an important role in RNA stability and in regulating its subsequent fate. In recent years, however, it has become clear that alternative, non-canonical RNA caps also exist, although their formation and the mechanisms by which they are attached to RNA remain only partially understood. These include alarmone caps, formed by dinucleoside polyphosphate molecules, that protect cellular RNA at moments when the cell is under threat.</p><p>In their study,<strong> </strong><a target="_blank" rel="noopener noreferrer" href="https://cahova.group.uochb.cz/en"><strong>Dr. Hana Cahová</strong></a> and colleagues examined bacterial RNA polymerase and investigated how this enzyme can initiate transcription using dinucleoside polyphosphates (NpNs) instead of the standard RNA building blocks. For the first time, the scientists described, at the atomic level, how RNA bearing an alarmone cap can be generated directly at the initiation of gene transcription. They also observed that NpNs bind through a different type of base pairing than is typically observed.</p><p>The work was significantly shaped by <strong>Valentina Serianni from Hana Cahová’s team</strong>, who demonstrated the ability of dinucleoside polyphosphates to initiate gene transcription, and by <strong>Jana Škerlová</strong>, who focused on the structural analysis of RNA polymerase. Using cryogenic electron microscopy data, she showed how dinucleoside polyphosphate molecules bind within the active site of RNA polymerase – that is, the core of the enzyme where genetic information is transcribed. Together, their findings help to elucidate the processes that accompany the transcription of genetic information from DNA to RNA.</p><p>Hana Cahová adds: <i>“We’re describing something that truly occurs in cells and that we’re now able to observe directly at the level of individual molecules. This allows us to answer fundamental questions about cellular processes, such as how cells adapt to stress. RNA plays a central role in this, as it carries the cascade of information underlying any cellular response – for example, to threatening conditions caused by nutrient deprivation or temperature shock.”</i></p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/UOCHB_Vyzkum_z_UOCHB_odhaluje_dosud_nepoznany_zpusob_prepisu_geneticke_informace_2_0fe88ff9e9.jpg" alt="IOCB Prague/Tomáš Belloň: Research from IOCB Prague reveals a previously unknown mechanism of genetic transcription: Dr. Tomáš Kouba, head of the Cryogenic Electron Microscopy core facility." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_UOCHB_Vyzkum_z_UOCHB_odhaluje_dosud_nepoznany_zpusob_prepisu_geneticke_informace_2_0fe88ff9e9.jpg 234w," sizes="100vw" width="2000" height="1335"></p><div><p>Cryogenic electron microscopy (cryo-EM) was central to the project. This part of the work was led by<strong> Dr. Tomáš Kouba</strong>, one of the authors of the study. <i>“Cryogenic electron microscopy allows us to freeze biological molecules in a state very close to their natural form and then determine their three-dimensional structure. This makes it possible to look directly into the active centers of enzymes and observe their function down to the atomic level,”</i> he explains.</p><p>Last year, IOCB Prague opened a new <a target="_blank" rel="noopener noreferrer" href="https://cryoem.group.uochb.cz/en"><strong>cryo-EM center</strong></a><strong> </strong>that is unique within the Czech research environment. State-of-the-art cryogenic electron microscopes are housed in a specially designed building and enable the study of biological processes with exceptional structural precision.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/UOCHB_Vyzkum_z_UOCHB_odhaluje_dosud_nepoznany_zpusob_prepisu_geneticke_informace_3_4d881e7a58.jpg" alt="IOCB Prague: Research from IOCB Prague reveals a previously unknown mechanism of genetic transcription: This work shows how NpnNs initiate bacterial transcription. Cryo-EM reveals how nucleobases pair with the template: one in canonical and one in reverse Watson–Crick mode, providing a structural basis for their function as non-canonical RNA caps." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_UOCHB_Vyzkum_z_UOCHB_odhaluje_dosud_nepoznany_zpusob_prepisu_geneticke_informace_3_4d881e7a58.jpg 245w," sizes="100vw" width="2000" height="1077"></p><blockquote><h4><strong>The Original article</strong></h4><h4><a target="_blank" rel="noopener noreferrer" href="https://www.nature.com/articles/s41589-025-02134-5"><strong>Molecular insight into 5′ RNA capping with Np<sub>n</sub>Ns by bacterial RNA polymerase</strong></a></h4><p>Valentina M. Serianni, Jana Škerlová, Anna Knopp Dubánková, Anton Škríba, Hana Šváchová, Tereza Vučková, Anatolij Filimoněnko, Milan Fábry, Pavlína Řezáčová, Tomáš Kouba &amp; Hana Cahova&nbsp;</p><p>Nat. Chem. Biol. 21 (2026)</p><p><a target="_blank" rel="noopener noreferrer" href="https://doi.org/10.1038/s41589-025-02134-5">https://doi.org/10.1038/s41589-025-02134-5</a></p><h6>licensed under <a target="_blank" rel="noopener noreferrer" href="https://creativecommons.org/licenses/by/4.0/"><strong>CC-BY 4.0</strong></a></h6></blockquote><h4><strong>Abstract</strong></h4><p>RNA capped with dinucleoside polyphosphates has been discovered in bacteria and eukaryotes only recently. The likely mechanism of this specific capping involves direct incorporation of dinucleoside polyphosphates by RNA polymerase as noncanonical initiating nucleotides. However, how these compounds bind into the active site of RNA polymerase during transcription initiation is unknown. Here, we explored transcription initiation in vitro, using a series of DNA templates in combination with dinucleoside polyphosphates and model RNA polymerase from <i>Thermus</i> <i>thermophilus</i>. We observed that the transcription start site can vary on the basis of the compatibility of the specific template and dinucleoside polyphosphate. Cryo-electron microscopy structures of transcription initiation complexes with dinucleoside polyphosphates revealed that both nucleobase moieties can pair with the DNA template. The first encoded nucleotide pairs in a canonical Watson–Crick manner, whereas the second nucleobase pairs noncanonically in a reverse Watson–Crick manner. Our work provides a structural explanation of how dinucleoside polyphosphates initiate RNA transcription.</p></div></div>

Research from IOCB Prague reveals a previously unknown mechanism of genetic transcription

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Since its establishment in 2011, CEITEC has quickly developed into a cutting-edge infrastructure for research which performs highly alongside the best institutes in Europe. Among the main priorities of CEITEC are the promotion of a motivating and dynamic international scientific environment, the provision of state-of-the-art research infrastructure, and the policy of open communication and equal opportunities.

CEITEC

The University of Chemistry and Technology, Prague is a natural centre of first-rate study and research in the area of chemistry in Czechia and is one of the country's largest educational and research institutions focused on technical chemistry, chemical and biochemical technologies, material and chemical engineering, food chemistry, and environmental studies.

UCT Prague

The Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences (IOCB Prague) is a leading scientific institution in the Czech Republic, recognized internationally. Its primary mission is basic research in the fields of chemical biology and medicinal chemistry, organic and material oriented chemistry, chemistry of natural compounds, biochemistry and molecular biology, physical chemistry, theoretical chemistry, and analytical chemistry. 

Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences

Mettler-Toledo

Bruker

<div><p><strong>This webinar will provide an overview of Chemical Exchange Saturation Transfer (CEST) MRI, from its physical principles and experimental design to the key factors influencing endogenous CEST signals in vivo. We will explore both physiological and technical sources of contrast, the complexity of in vivo CEST signals, and common artifacts such as fat contamination and field inhomogeneities.</strong></p><p>The session will also highlight essential correction strategies for achieving quantitative CEST MRI and showcase current applications in cancer and neuroimaging. Preclinical studies at ultra-high magnetic fields—such as the DKFZ’s 9.4 T Bruker system—play a key role in advancing methodological development, enabling a deeper understanding of complex CEST signal behavior in vivo and paving the way for clinical translation.</p><h5><strong>What to Expect</strong></h5><p>Join Dr. Philip S. Boyd for an in-depth exploration of Chemical Exchange Saturation Transfer (CEST) MRI, covering its theoretical foundations, practical implementation, and cutting-edge applications in cancer and neuroimaging. This webinar will guide attendees through the complexities of in vivo CEST signals, correction strategies for artifacts, and the translation of preclinical findings into clinical practice.</p><h5><strong>Key Learning Points</strong></h5><ul><li>Understanding the CEST Phenomenon and Theory</li><li>Applications in Cancer and Neuroimaging</li><li>Achieving Quantitative CEST imaging In Vivo</li></ul><h5><strong>Who should attend:</strong></h5><p>This webinar is ideal for researchers, clinicians, and imaging specialists working in MRI, oncology, neurology, or molecular imaging who are interested in advancing their understanding of quantitative CEST techniques and their translational potential. It will also be highly educational for graduate students and early-career scientists beginning their journey in MRI, offering foundational insights and practical guidance.</p><blockquote><p><strong>Presenter:</strong> Dr. Philip S. Boyd (Ph.D. in Physics from Heidelberg University and leads the CEST Imaging Group at the German Cancer Research Center (DKFZ) in Heidelberg)</p><p>Dr. Philip S. Boyd holds a Ph.D. in Physics from Heidelberg University and leads the CEST Imaging Group at the German Cancer Research Center (DKFZ) in Heidelberg. His research focuses on developing and refining advanced CEST imaging techniques, including pH imaging and fat artifact correction. He combines experimental imaging, mathematical modeling, and data analysis to drive CEST applications from preclinical research to clinical translation.</p></blockquote></div>

Bruker: Quantitative CEST MRI: From Principles to Applications in Cancer and Neuroimaging

Quantitative CEST MRI: From Principles to Applications in Cancer and Neuroimaging

Discover how CEST MRI works and how it's applied in cancer and neuroimaging. With insights from DKFZ’s cutting-edge preclinical studies.

Quantitative CEST MRI: From Theory to Clinical Insight

<header><h4><strong>How to Determine the Thermal and Mechanical Properties of Electronic Materials</strong></h4></header><main><div><div><h5><strong>Program</strong></h5><ul><li>Introduction to electronics and PCBs</li><li>How thermal analysis is used in the electronics industry</li><li>Introduction to thermal analysis techniques</li><li>Real-life application examples using DSC, TGA, TMA, and DMA</li><li>Interactive Q&amp;A session</li></ul></div></div><div><div><div><p>The field of electronics involves components such as transistors, diodes, wires and integrated circuits, which are usually mounted on printed circuit boards (PCBs). PCBs are classified as composite material and consist of a carrier material, typically a glass fiber fabric, and a matrix such as epoxy resin.</p><p>The thermal and mechanical properties of electronic components have a significant effect on their use case and lifetime. For example, PCBs can suffer from delamination at high temperatures. Thermal analysis can be used to characterize many types of components and to guide design and production processes.</p><p>Join our upcoming webinar to find out how thermal analysis is used to investigate materials used in the electronics industry. We will present real-life examples of samples measured by DSC, TGA, TMA, and DMA. Understand your material behavior and boost your thermal analysis knowledge.</p><h4><strong>How Is Thermal Analysis Used for Characterizing Electronic Components?</strong></h4><p>The most important effects that can be analyzed by DSC for the electronics industry are curing, glass transitions, crystallization, and melting temperature. DSC is also used to determine the heat of fusion, and oxidation stability.</p><ul><li><strong>TGA </strong>measures weight changes. The main applications of TGA are thermal stability, decomposition kinetics, and the analysis of composition.</li><li><strong>TMA</strong> is normally used to study the expansion, shrinkage, and softening of materials and the glass transition.</li><li><strong>DMA</strong> is used to determine the modulus and damping behavior of materials.</li></ul><p>Don’t miss this opportunity to gain in-depth knowledge on characterizing electronic materials, such as PCBs, adhesives, solder, metals, alloys, composites, and plastics. Register now to secure your spot, and be sure to prepare your questions for our experts!</p></div><div><div data-advanced-option="false" data-has-preview-image="false" data-video-id="" data-component-id="2110920040"><div style="max-width:1px;width:100%;" id="mediaContainerWrapper_2110920040"><div style="height:1px;width:1px;" data-external-url="" id="mediaContainer_2110920040" data-advanced-option="false" data-width="1" data-height="1" data-video-id="">&nbsp;</div></div></div></div></div></div></main><div><div><div data-advanced-option="false" data-has-preview-image="false" data-video-id="" data-component-id="2110920040"><blockquote><div><strong>Presenter: </strong>Angela Hammer (Dr. sc. nat. ETH)</div><p>Dr. Angela Hammer received a Ph.D. in Analytical Chemistry (development of immobilized components for the use in ion-selective electrodes based on polyurethane membranes) from the Institute of Organic Chemistry at the Swiss Federal Institute of Technology in Zürich, Switzerland. She then joined Sika Technology AG in Zurich, Switzerland, as an analytical chemist. In 2007, she joined METTLER TOLEDO and has worked there since as an application specialist for Thermal Analysis. In her present position, she uses, teaches, and supports DSC, TGA, TMA, and DMA instruments for the METTLER TOLEDO’s Materials Characterization Group located at the head office in Switzerland.</p></blockquote></div></div></div>

Mettler Toledo: Thermal Analysis of Electronic Components

Thermal Analysis of Electronic Components

Discover how thermal analysis (DSC, TGA, TMA, DMA) characterizes electronic materials and PCBs, supporting design, reliability, and lifetime performance.

<header><h4><strong>Discover Basic Principles and Practical Applications</strong></h4></header><main><div><div><h5><strong>Program</strong></h5><ul><li>Introduction to viscoelasticity</li><li>Principles of dynamic mechanical analysis</li><li>DMA measurement options</li><li>How DMA is used in different industries</li><li>Real-life analysis examples</li><li>Interactive Q&amp;A session</li></ul></div></div><div><div><div><p>Dynamic mechanical analysis (DMA) is a well-established technique for characterizing the mechanical properties of many different materials. These include plastics, adhesives, composites, rubber, coatings, films, and fibers. It is an excellent technique for determining effects such as the glass transition, curing, modulus, damping, viscoelasticity, and vulcanization.</p><h4><strong>What Type of Information Can We Get From DMA?</strong></h4><p>DMA provides quantitative and qualitative information on:</p><ul><li>Young’s modulus and shear modulus values</li><li>Damping characteristics and viscoelastic behavior</li><li>Polymer structure and morphology</li><li>Flow and relaxation behavior</li></ul><p>This type of information is very important for the research and development of new materials, as well as for quality control and failure analysis.</p><p>Are you ready to deepen your understanding of DMA and expand your thermal analysis knowledge? &nbsp;Join our upcoming webinar to learn more about DMA and explore real-life applications in a range of industries.</p><p>Register now to secure your spot, and be sure to prepare your questions for our experts!</p></div><div><div data-advanced-option="false" data-has-preview-image="false" data-video-id="" data-component-id="2110920040"><div style="max-width:1px;width:100%;" id="mediaContainerWrapper_2110920040"><div style="height:1px;width:1px;" data-external-url="" id="mediaContainer_2110920040" data-advanced-option="false" data-width="1" data-height="1" data-video-id="">&nbsp;</div></div></div></div></div></div></main><div><div><div data-advanced-option="false" data-has-preview-image="false" data-video-id="" data-component-id="2110920040"><blockquote><div><strong>Presenter: </strong>Angela Hammer (Dr. sc. nat. ETH)</div><p>Dr. Angela Hammer received a Ph.D. in Analytical Chemistry (development of immobilized components for the use in ion-selective electrodes based on polyurethane membranes) from the Institute of Organic Chemistry at the Swiss Federal Institute of Technology in Zürich, Switzerland. She then joined Sika Technology AG in Zurich, Switzerland, as an analytical chemist. In 2007, she joined METTLER TOLEDO and has worked there since as an application specialist for Thermal Analysis. In her present position, she uses, teaches, and supports DSC, TGA, TMA, and DMA instruments for the METTLER TOLEDO’s Materials Characterization Group located at the head office in Switzerland.</p></blockquote></div></div></div>

Mettler Toledo: Dynamic Mechanical Analysis (DMA)

Dynamic Mechanical Analysis (DMA)

Join this webinar to understand DMA principles, viscoelastic behavior, and practical applications for material testing across industries.

<header><h4><strong>How to Use Thermal Analysis to Improve Safety in the Chemical Industry</strong></h4></header><main><div><div><h5><strong>Program</strong></h5><ul><li>Basic concepts of safety analysis: time to maximum rate, criticality of a reaction</li><li>Thermal analysis and reaction calorimetry applications</li><li>Industry applications: differential scanning calorimetry (DSC)</li><li>Industry applications: thermogravimetry (TGA)</li><li>Interactive Q&amp;A session</li></ul></div></div><div><div><div><p>Accident prevention in chemical production plants is a critical topic, and avoiding incidents that could cause casualties or environmental harm is paramount. Thermal runaway reactions are often at the root of such incidents and must be effectively managed. By using thermal analysis and reaction calorimetry, you can easily assess the thermal safety of chemicals and processes. This means that thermal hazards can be identified at an early stage of process development, saving time, costs, and lives.</p><p>Join this live webinar to learn how thermal analysis techniques—DSC and TGA—are used to investigate hazardous compounds and conduct safety studies in the chemical industry. We will present real-life examples of safety investigations using these techniques.</p><p>Don’t miss the live <strong>Q&amp;A session</strong> where you can ask our experts your own questions. Secure your spot today.</p><h4><strong>How to Use Thermal Analysis for Safety Assessment</strong></h4><ul><li><strong>DSC</strong> is typically used to investigate the thermal safety aspects of individual chemicals. Reaction calorimetry is used to provide safety information about processes, for example, to determine the heat flow during the dosing of reactants or during stirring.</li><li><strong>TGA </strong>is useful for determining evaporation, desorption, and vaporization behavior, as well as thermal stability and the decomposition kinetics.</li><li><strong>Evolved gas analysis</strong> techniques are used to gain information about the products evolved during a decomposition reaction. The TGA module is combined with a technique, such as FTIR, MS, or GC-MS.</li><li><strong>TGA/DSC</strong> combines two different thermal analysis techniques to provide complementary information about a sample's thermal behavior.</li></ul><p>Don’t miss this opportunity to gain in-depth knowledge on safety evaluations for the chemical industry.&nbsp;</p></div><div><div data-advanced-option="false" data-has-preview-image="false" data-video-id="" data-component-id="2110920040"><div style="max-width:1px;width:100%;" id="mediaContainerWrapper_2110920040"><div style="height:1px;width:1px;" data-external-url="" id="mediaContainer_2110920040" data-advanced-option="false" data-width="1" data-height="1" data-video-id="">&nbsp;</div></div></div></div></div></div></main><div><div><div data-advanced-option="false" data-has-preview-image="false" data-video-id="" data-component-id="2110920040"><blockquote><div><strong>Presenter: </strong>Dr. Teresa Dennenwaldt</div><p>Dr. Teresa Dennenwaldt obtained her PhD in chemistry in 2013 and completed a postdoc at the Ecole Polytechnique Fédérale de Lausanne, Switzerland in the field of electron microscopy and spectroscopy. In 2018, she joined METTLER TOLEDO as an application specialist for Thermal Analysis. In her current position, she expertly uses, teaches, and supports DSC, TGA, TMA, and DMA instruments at the METTLER TOLEDO head office in Switzerland.</p></blockquote></div></div></div>

Mettler Toledo: Thermal Analysis for Safety Evaluation of Chemical Processes

Thermal Analysis for Safety Evaluation of Chemical Processes

Join this webinar to explore how thermal analysis helps identify thermal hazards, improve process safety, and prevent runaway reactions in chemical production.

<header><h4><strong>Discover Six Different DSC Methods for Determining this Important Material Property</strong></h4></header><main><div><div><h5><strong>Program</strong></h5><ul><li>Definition of specific heat capacity</li><li>Importance of specific heat capacity</li><li>Presentation of the six DSC measurement methods in the STARe software</li><li>Measurement tips and hints</li><li>Interactive Q&amp;A session</li></ul></div></div><div><div><div><p>Specific heat capacity (cp) is the energy needed to increase the temperature of one unit of mass of material by exactly 1 °C. It is typically determined using differential scanning calorimetry (DSC) due to ease of use, short measurement times and accuracy.</p><p>Specific heat capacity is a characteristic, temperature-dependent, material property that is often specified in data sheets. It is a key property for improving technical processes such as injection molding, spray drying, and crystallization. It is critical in the safety analysis of chemical processes and design of chemical reactors.</p><h4><strong>Measurement Methods Discussed in the Webinar</strong></h4><p>Join our upcoming webinar where we present six different methods of calculating specific heat capacity. We first present the so-called <strong>Direct</strong> and <strong>Sapphire</strong> methods using a conventional DSC instrument and a linear temperature program. We then demonstrate four temperature-modulated DSC techniques: <strong>IsoStep DSC, Steady State ADSC, ADSC, and TOPEM</strong>.</p><p>Don’t miss this opportunity to gain in-depth knowledge about determining this critical material property. Register now and be sure to prepare your questions for our experts!</p><h4><strong>Heat Capacity vs Specific Heat Capacity</strong></h4><ul><li><strong>Heat capacity</strong> is the amount of energy needed to increase the temperature of an object by exactly 1 °C. Hence it is related to the size of the sample and does not characterize the material itself. The unit of heat capacity, Cp, is Joules per Kelvin (J/K).</li><li><strong>Specific heat capacity</strong> is the energy needed to increase the temperature of one unit of mass of an object by exactly 1 °C. This is calculated by dividing the heat capacity by the sample mass, which provides a more useful characterization of the material. The unit of specific heat capacity, cp, is typically expressed as Joules per gram per Kelvin (J/g/K).</li></ul></div><div><div data-advanced-option="false" data-has-preview-image="false" data-video-id="" data-component-id="2110920040"><div style="max-width:1px;width:100%;" id="mediaContainerWrapper_2110920040"><div style="height:1px;width:1px;" data-external-url="" id="mediaContainer_2110920040" data-advanced-option="false" data-width="1" data-height="1" data-video-id="">&nbsp;</div></div></div></div></div></div></main><div><div><div data-advanced-option="false" data-has-preview-image="false" data-video-id="" data-component-id="2110920040"><blockquote><div><strong>Presenter: </strong>Angela Hammer (Dr. sc. nat. ETH)</div><p>Dr. Angela Hammer received a Ph.D. in Analytical Chemistry (development of immobilized components for the use in ion-selective electrodes based on polyurethane membranes) from the Institute of Organic Chemistry at the Swiss Federal Institute of Technology in Zürich, Switzerland. She then joined Sika Technology AG in Zurich, Switzerland, as an analytical chemist. In 2007, she joined METTLER TOLEDO and has worked there since as an application specialist for Thermal Analysis. In her present position, she uses, teaches, and supports DSC, TGA, TMA, and DMA instruments for the METTLER TOLEDO’s Materials Characterization Group located at the head office in Switzerland.</p></blockquote></div></div></div>

Mettler Toledo: How to Determine Specific Heat Capacity by DSC

How to Determine Specific Heat Capacity by DSC

Explore six DSC techniques for measuring specific heat capacity and understand its importance in material performance, processing, and safety.

<header><h4><strong>Discover Useful Applications for Characterizing These Unique Materials</strong></h4></header><main><div><div><h5><strong>Program</strong></h5><ul><li>Introduction to nanomaterials</li><li>Basic properties and uses</li><li>Relevant thermal analysis techniques</li><li>Industries and suitable investigations</li><li>Application examples for industry and research (DSC, Flash DSC, TGA, and DMA)</li><li>Interactive Q&amp;A session</li></ul></div></div><div><div><div><p>Nanomaterials exhibit unique and diverse properties that enable a wide range of innovative applications. Their unique properties enhance catalysis, improve mechanical strength, and can even provide antibacterial effects in clothing. Their nanoscale size facilitates nucleation and also influences magnetic behavior.</p><p>Understanding the behavior of nanomaterials is crucial for harnessing their unique properties. This knowledge enables their use in advanced materials and innovative technological applications.</p><p><strong>Join our live webinar to explore how thermal analysis techniques can reveal the unique properties of nanomaterials.</strong></p><p>Be sure to prepare your questions for the live Q&amp;A with our experts!</p><h4><strong>Thermal Analysis Techniques for Characterizing Nanomaterials</strong></h4><ul><li><strong>DSC and Flash DSC</strong> are important techniques used to determine the glass transition, melting, crystallization behavior, reaction enthalpies and kinetics, and the influence of nanoparticle fillers.</li><li><strong>TGA</strong> is used to investigate stability, decomposition behavior and water sorption of nanomaterials.</li><li><strong>DMA</strong> is useful for characterizing the influence of nanoparticles on the mechanical behavior of viscoelastic materials as a function of time, temperature, and frequency of an oscillating stress.</li></ul><p>Don't miss the chance to deepen your understanding of thermal analysis techniques for characterizing these unique materials. Reserve your spot today!</p><h4><strong>Properties and Uses of Nanomaterials</strong></h4><p>The unique properties of nanomaterials enable diverse applications. For example, due to their high surface area, inefficient or unfavorable chemical reactions can often be improved by nanoparticle <strong>catalysts</strong>. When integrated into bulk materials, nanoparticles can <strong>tailor mechanical properties</strong> for advanced performance. Silver nanoparticles impart <strong>antibacterial qualities to clothing</strong>, preventing odors by eliminating bacteria. Additionally, their nanoscale size facilitates <strong>nucleation</strong>, aiding crystallization of larger molecules that would otherwise have difficulty crystallizing on their own.</p><p>Other uses of nanomaterials include structures such as <strong>silica gels </strong>and <strong>molecular sieves</strong> that have functional geometries on a nanoscale. Magnetic behavior can also vary with nanoparticle size, influencing <strong>magnetization dynamics</strong>.</p><p>These fascinating characteristics make nanomaterials pivotal in cutting-edge technology and materials science.&nbsp;</p></div><div><div data-advanced-option="false" data-has-preview-image="false" data-video-id="" data-component-id="2110920040"><div style="max-width:1px;width:100%;" id="mediaContainerWrapper_2110920040"><div style="height:1px;width:1px;" data-external-url="" id="mediaContainer_2110920040" data-advanced-option="false" data-width="1" data-height="1" data-video-id="">&nbsp;</div></div></div></div></div></div></main><div><div><div data-advanced-option="false" data-has-preview-image="false" data-video-id="" data-component-id="2110920040"><blockquote><div><strong>Presenter: </strong>Nicolas Fedelich</div><p>With a background in chemical engineering, Nicolas joined METTLER TOLEDO in 2009 as an application specialist for thermal analysis. Before that, he gained expertise in different laboratories implementing, developing, and validating analytical methods in both the pharmaceutical and environmental fields. Nicolas also worked for three years in the field carrying out on-site customer training and providing expert thermal analysis application support. In his present position, Nicolas expertly uses, teaches, and supports DSC, TGA, TMA, and DMA instruments at the METTLER TOLEDO head office in Switzerland.</p></blockquote></div></div></div>

Mettler Toledo: Thermal Analysis of Nanomaterials

Thermal Analysis of Nanomaterials

Join our live webinar to explore how thermal analysis techniques can reveal the unique properties of nanomaterials.

<header><h4><strong>A Guide to Choosing the Optimal Crucible for Your Experiment</strong></h4></header><main><div><div><h5><strong>Program</strong></h5><ul><li>Introduction to thermal analysis crucibles</li><li>DSC crucibles and application examples</li><li>TGA crucibles and application examples</li><li>Tips and hints for selecting the right crucible</li><li>Interactive Q&amp;A session</li></ul></div></div><div><div><div><p>Selecting the right crucible for your application can be a complex process, given the wide range of products available. Making the right choice, however, is essential for obtaining accurate results and protecting your thermal analysis module.</p><p>Using several practical examples for differential scanning calorimetry (<strong>DSC</strong>) and thermogravimetric analysis (<strong>TGA</strong>), this webinar helps you navigate through the many different choices, giving you confidence in your results.</p><p>After the presentation, you will have the opportunity to join the live Q&amp;A session with our experienced METTLER TOLEDO application specialists. &nbsp;</p><p>Want to learn more? Register for our webinar today!</p><h4><strong>Why Using the Right Crucible Is Essential</strong></h4><p>Often, the difference between an accurate and a flawed result has nothing to do with the measuring device, but rather the type of crucible used. For example:</p><ul><li>Crucible material, size, quality, and lids must be carefully selected, according to the application.</li><li>A smooth, flat base is critical to ensure perfect contact with the sample and optimal heat transfer.</li></ul><p>Join our live webinar and discover useful tips and hints on how to select the correct crucible for different types of DSC and TGA applications</p><p><strong>Don’t forget to prepare your questions for the live Q&amp;A with our experts!</strong></p></div><div><div data-advanced-option="false" data-has-preview-image="false" data-video-id="" data-component-id="2110920040"><div style="max-width:1px;width:100%;" id="mediaContainerWrapper_2110920040"><div style="height:1px;width:1px;" data-external-url="" id="mediaContainer_2110920040" data-advanced-option="false" data-width="1" data-height="1" data-video-id="">&nbsp;</div></div></div></div></div></div></main><div><div><div data-advanced-option="false" data-has-preview-image="false" data-video-id="" data-component-id="2110920040"><blockquote><div><strong>Presenter: </strong>Angela Hammer (Dr. sc. nat. ETH)</div><p>Dr. Angela Hammer received a Ph.D. in Analytical Chemistry (development of immobilized components for the use in ion-selective electrodes based on polyurethane membranes) from the Institute of Organic Chemistry at the Swiss Federal Institute of Technology in Zürich, Switzerland. She then joined Sika Technology AG in Zurich, Switzerland, as an analytical chemist. In 2007, she joined METTLER TOLEDO and has worked there since as an application specialist for Thermal Analysis. In her present position, she uses, teaches, and supports DSC, TGA, TMA, and DMA instruments for the METTLER TOLEDO’s Materials Characterization Group located at the head office in Switzerland.</p></blockquote></div></div></div>

Mettler Toledo: Crucible Selection for Thermal Analysis

Crucible Selection for Thermal Analysis

Join our live webinar and discover useful tips and hints on how to select the correct crucible for different types of DSC and TGA applications

<header><h4><strong>Useful Techniques for Identification and Characterization</strong></h4></header><main><div><div><h5><strong>Program</strong></h5><ul><li>What are thermosets? Basic properties and formation</li><li>Thermal analysis techniques for studying thermosets</li><li>Application examples using DSC, TGA, TMA, and DMA</li><li>Which technique should be used in your analysis?</li><li>Interactive Q&amp;A session</li></ul></div></div><div><div><div><p>A thermoset is a polymer that undergoes a particular chemical reaction, known as curing, to form a permanent, heavily cross-linked structure. The material cannot be melted or remolded to form a new shape, even at high temperatures. Thermosets are typically rigid and insoluble, with high mechanical strength and temperature stability. Examples include epoxy resins, phenolic resins, polyesters, and polyurethanes.</p><p>Due to their highly temperature-dependent physical behavior, thermal analysis is an ideal set of techniques for identifying and characterizing these materials.</p><p>This webinar discusses the most important thermal properties of thermosets and describes useful thermal analysis techniques used to analyze them.</p><p><strong>Register now to secure your spot and join the live Q&amp;A!</strong></p><h4><strong>How to Characterize Thermosets</strong></h4><p>Different thermal techniques can be used to determine the key properties of these materials:</p><ul><li><strong>DSC:</strong> Useful for determining glass transition, melting, reaction enthalpies, curing and thermal stability.</li><li><strong>TGA:</strong> Mainly used for composition analysis, thermal stability, decomposition, evaporation, and desorption behavior.</li><li><strong>TMA: </strong>Typically used to study mechanical behavior such as expansion, shrinkage, softening, plus glass transition.</li><li><strong>DMA: </strong>Best for studying viscoelastic behavior, glass transition, and frequency-dependent effects.</li></ul><h4><strong>What is a Typical Analysis of a Thermoset?</strong></h4><p>A typical and important analysis of a thermoset is the characterization of epoxy resin materials. In this case, determining the glass transition temperature (Tg) and investigating the curing reaction are highly important. This information can be used in manufacturing, for example testing the process conditions required to properly cure thermosets. It can also be used in quality control, to check the expected Tg of a known material.&nbsp;</p></div><div><div data-advanced-option="false" data-has-preview-image="false" data-video-id="" data-component-id="2110920040"><div style="max-width:1px;width:100%;" id="mediaContainerWrapper_2110920040"><div style="height:1px;width:1px;" data-external-url="" id="mediaContainer_2110920040" data-advanced-option="false" data-width="1" data-height="1" data-video-id="">&nbsp;</div></div></div></div></div></div></main><div><div><div data-advanced-option="false" data-has-preview-image="false" data-video-id="" data-component-id="2110920040"><blockquote><div><strong>Presenter: </strong>Dr. Teresa Dennenwaldt</div><p>Dr. Teresa Dennenwaldt obtained her PhD in chemistry in 2013 and completed a postdoc at the Ecole Polytechnique Fédérale de Lausanne, Switzerland in the field of electron microscopy and spectroscopy. In 2018, she joined METTLER TOLEDO as an application specialist for Thermal Analysis. In her current position, she expertly uses, teaches, and supports DSC, TGA, TMA, and DMA instruments at the METTLER TOLEDO head office in Switzerland.</p></blockquote></div></div></div>

Mettler Toledo: Thermal Analysis of Thermoset Materials

Thermal Analysis of Thermoset Materials

This webinar discusses the most important thermal properties of thermosets and describes useful thermal analysis techniques used to analyze them.

<header><h4><strong>Learn Basic DSC Principles and Find Useful Applications for Your Workplace</strong></h4></header><main><div><div><h5><strong>Program</strong></h5><ul><li>Basic principles of DSC with an explanation of power compensation and heat flux modes</li><li>Important components of the DSC measurement cell, the innovative sensor, and modules for specialized applications</li><li>Measurement parameters such as the temperature program and choice of atmosphere</li><li>Why you should use DSC for your analysis</li><li>Application examples for different industries</li><li>Live Q&amp;A session</li></ul></div></div><div><div><div><p><strong>Differential Scanning Calorimetry (DSC)</strong> is used to study the behavior of materials as they respond to a defined temperature program. The technique measures the heat, in mW, absorbed or released by a sample as it is heated, cooled, or held at a constant temperature. Measurement results are presented in the form of a curve, from which the glass transition, crystallization, melting, and many other thermal properties can be determined.</p><p>The DSC technique has applications in a wide range of industries. For example, checking the “fingerprint” of a measurement curve is a common application for quality control purposes. Other applications include investigating the influence of additives or different processing methods on a substance.</p><p>Join our webinar on DSC to gain knowledge and get the opportunity to ask our experts your questions!</p></div><div><div data-advanced-option="false" data-has-preview-image="false" data-video-id="" data-component-id="2110920040"><div style="max-width:1px;width:100%;" id="mediaContainerWrapper_2110920040"><div style="height:1px;width:1px;" data-external-url="" id="mediaContainer_2110920040" data-advanced-option="false" data-width="1" data-height="1" data-video-id="">&nbsp;</div></div></div></div></div></div></main><div><div><div data-advanced-option="false" data-has-preview-image="false" data-video-id="" data-component-id="2110920040"><blockquote><div><strong>Presenter: </strong>Dr. Teresa Dennenwaldt</div><p>Dr. Teresa Dennenwaldt obtained her PhD in chemistry in 2013 and completed a postdoc at the Ecole Polytechnique Fédérale de Lausanne, Switzerland in the field of electron microscopy and spectroscopy. In 2018, she joined METTLER TOLEDO as an application specialist for Thermal Analysis. In her current position, she expertly uses, teaches, and supports DSC, TGA, TMA, and DMA instruments at the METTLER TOLEDO head office in Switzerland.</p></blockquote></div></div></div>

Mettler Toledo: Differential Scanning Calorimetry

Differential Scanning Calorimetry

Join our webinar on DSC to gain knowledge and get the opportunity to ask our experts your questions!

<header><h4><strong>Practical Applications and Tips to Determine the Purity of a Substance</strong></h4></header><main><div><div><h5><strong>Program</strong></h5><ul><li>What does purity mean and how does it impact your products?</li><li>The basics of DSC and the van’t Hoff law for purity analysis</li><li>Advantages of DSC compared to other techniques</li><li>Application examples – real-world purity determinations</li><li>Interactive Q&amp;A with our experts</li></ul></div></div><div><div><div><p>The purity of ingredients, especially in pharmaceuticals and food products, is a critical quality attribute. High impurity levels can affect product efficacy, cause unexpected reactions, or even generate harmful compounds. Therefore, accurate purity determination is essential for the pharmaceutical, food, chemical, and plastics industries.</p><p>In this webinar, we will explain why differential scanning calorimetry (DSC) is a reliable technique for assessing the purity of organic substances, based on the thermodynamics of eutectic systems.</p><p><strong>Join us to enhance your knowledge, ask us your questions, and discover practical applications for your industry!</strong></p><h4><strong>What You Will Learn from This Webinar</strong></h4><p>In this session, you will learn how DSC is used to determine the purity of organic substances based on the <strong>thermodynamics of a eutectic system</strong>. We explain how the purity of a substance can be determined from a single DSC measurement using the <strong>van’t Hoff equation</strong>. Importantly, DSC purity measurements are rapid and easy to perform.</p><p>This versatile technique can be used across different industries and workplaces, including research and development, industrial synthesis, and quality control. Typical determinations by DSC include:</p><ul><li>Purity of ibuprofen</li><li>Purity of p-hydroxybenzoic acid (PHBA)</li><li>Determination of eutectic impurities such as benzoic acid in dimethyl terephthalate (DMT)</li></ul><p>Register for our upcoming live webinar to learn more about using DSC for purity determination. The webinar will conclude with a <strong>live Q&amp;A session</strong>, so get your questions ready!</p></div><div><div data-advanced-option="false" data-has-preview-image="false" data-video-id="" data-component-id="2110920040"><div style="max-width:1px;width:100%;" id="mediaContainerWrapper_2110920040"><div style="height:1px;width:1px;" data-external-url="" id="mediaContainer_2110920040" data-advanced-option="false" data-width="1" data-height="1" data-video-id="">&nbsp;</div></div></div></div></div></div></main><div><div><div data-advanced-option="false" data-has-preview-image="false" data-video-id="" data-component-id="2110920040"><blockquote><div><strong>Presenter: </strong>Nicolas Fedelich</div><p>With a background in chemical engineering, Nicolas joined METTLER TOLEDO in 2009 as an application specialist for thermal analysis. Before that, he gained expertise in different laboratories implementing, developing, and validating analytical methods in both the pharmaceutical and environmental fields. Nicolas also worked for three years in the field carrying out on-site customer training and providing expert thermal analysis application support. In his present position, Nicolas expertly uses, teaches, and supports DSC, TGA, TMA, and DMA instruments at the METTLER TOLEDO head office in Switzerland.</p></blockquote></div></div></div>

Mettler Toledo: Purity Determination by Differential Scanning Calorimetry (DSC)

Purity Determination by Differential Scanning Calorimetry (DSC)

In this webinar, we will explain why DSC is  reliable technique for assessing purity of organic substances, based on thermodynamics of eutectic systems.

ICPMS webinars focusing on Academy/Principles - page 1