News from LabRulezICPMS Library - Week 39, 2024

Researchers can use the light naturally thrown off by biological specimens to better study the different states of stem cells in the nervous system, thanks to a tool developed at the University of Wisconsin–Madison, brightening their chances for studying the way stem cells age.The UW–Madison team combined autofluorescence — that natural light emission — and sequencing genetic material in single cells to study the behavior of neural stem cells. Autofluorescence is often considered a hindrance, as it can obscure the glowing labels researchers use to track specific signals within a cell. In their new technique, however, the researchers found the signatures of autofluorescence can be used to study stem cells’ dormant state, known as quiescence.They <a target="_blank" rel="noopener noreferrer" href="https://www.cell.com/cell-stem-cell/abstract/S1934-5909(24)00054-7">published their findings</a> recently in the journal Cell Stem Cell.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/University_of_Wisconsin_Madison_Darcie_Moore_New_tool_provides_researchers_with_improved_understanding_of_stem_cell_aging_in_the_brain_Patterns_in_the_tiny_amounts_of_light_emitted_by_e9c03a580e.jpg" alt="University of Wisconsin-Madison / Darcie Moore: Patterns in the tiny amounts of light emitted by these neural stem cells helped researchers determine whether they were active or dormant without destructive testing." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_University_of_Wisconsin_Madison_Darcie_Moore_New_tool_provides_researchers_with_improved_understanding_of_stem_cell_aging_in_the_brain_Patterns_in_the_tiny_amounts_of_light_emitted_by_e9c03a580e.jpg 245w," sizes="100vw" width="888" height="500">“The quiescent state is very important, because the exit from quiescence is the rate-limiting step in making newborn neurons in the adult brain. Aging and neurological diseases limit this exit from quiescence, so we have a great need to study adult neural stem cells in their different cell states,” says <a target="_blank" rel="noopener noreferrer" href="https://stemcells.wisc.edu/staff/moore-darcie-l/">Darcie Moore</a>, the senior author on the study, a professor of neuroscience and member of UW–Madison’s Stem Cell and Regenerative Medicine Center. “Our goal was to create a new tool that could identify if an adult neural stem cell was quiescent and its different substates (dormant or resting quiescence), or if the cell is activated, entering into the cell cycle.”<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/University_of_Wisconsin_Madison_New_tool_provides_researchers_with_improved_understanding_of_stem_cell_aging_in_the_brain_Darcie_Moore_46c044de8e.jpg" alt="University of Wisconsin-Madison: Darcie Moore." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_University_of_Wisconsin_Madison_New_tool_provides_researchers_with_improved_understanding_of_stem_cell_aging_in_the_brain_Darcie_Moore_46c044de8e.jpg 245w," sizes="100vw" width="543" height="300">Moore partnered with <a target="_blank" rel="noopener noreferrer" href="https://stemcells.wisc.edu/staff/skala-melissa/">Melissa Skala</a>, a UW–Madison biomedical engineering professor, Morgridge Institute for Research investigator and member of the Stem Cell and Regenerative Medicine Center whose lab has been developing fluorescence lifetime imaging to study the autofluorescent signatures associated with single cells.When cells shift from active to quiescent states, the presence and abundance of certain proteins important to metabolism change. These molecules alter the way light is absorbed and emitted back out of the cell. By focusing on light emitted by parts of the cell that change in key ways with quiescence, the researchers identified the light “signature” that matches a target cell state.“These natural signals within the cell can reliably identify cell function and identity,” Skala says. “It’s like nature is trying to tell us all the secrets of life.”<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/University_of_Wisconsin_Madison_New_tool_provides_researchers_with_improved_understanding_of_stem_cell_aging_in_the_brain_Melissa_Skala_a33054f9c6.jpg" alt="University of Wisconsin-Madison: Melissa Skala." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_University_of_Wisconsin_Madison_New_tool_provides_researchers_with_improved_understanding_of_stem_cell_aging_in_the_brain_Melissa_Skala_a33054f9c6.jpg 245w," sizes="100vw" width="453" height="266">By sequencing RNA — a kind of working copy of DNA used to produce the proteins that make things happen in cells — in the mouse neural stem cells they studied, the researchers confirmed matches between cell state and light signatures.By identifying and decoding these autofluorescence signatures, Moore and Skala have developed a tool that can aid in studying adult neurological diseases and aging, but potentially also expand beyond neuroscience. They’ve already begun working with Colin Crist, a professor of human genetics at McGill University, to investigate the unique autofluorescent signatures present in muscle stem cells.“Now that we’ve discovered that this research created not only a tool but gave us unique insight to cellular processes that are different between quiescent and activated neural stem cells, I feel even more strongly that identifying a cell based on how they act versus how they express one protein will shift studies from studying static systems to dynamic systems,” says Moore. “That we can study these cells as they change throughout time without destroying them — while also seeing how these functional measures change — is very exciting.”This research was supported in part by grants from the National Institutes of Health (P30 CA014520, 1S10RR025483-01, T32GM008688 and 1DP2OD025783) as well as the Vallee Foundation, Morgridge Institute for Research and Retina Research Foundation.

New tool provides researchers with improved understanding of stem cell aging in the brain

<div class="bold">PFAS, thousands of artificial fluorinated chemicals. And nature doesn't know how to deal with them. These substances never decompose; they remain permanently in the environment. They accumulate in the bodies of humans and animals. That's&nbsp;how they get into our food, meat, milk, and eggs. We drink PFAS with our water, and they rain down on us in rainwater. They are produced massively because of their extraordinary properties. It is no exaggeration to say that all of us, including new-born, have these substances in our bodies. PFAS, known as forever chemicals, have many uses and are a&nbsp;part of every household. They are used in waterproof clothing, footwear, furniture coverings, disposable packaging, waterproofing sprays, cosmetics, and many other products. However, they are very dangerous; they are linked to lowering the immunity of toddlers and can cause cancer, infertility, hormonal problems, diabetes, etc. Thanks to Prof. Martin Scheringer (ETH Zurich/RECETOX), who was involved as a&nbsp;scientific expert, we are delighted to be part of the "The Forever Pollution Project” which aims to map the extent of PFAS contamination in Europe and make the information available to the public. Alarmingly, only three substances from this large group are banned. For the others, no legislation regulates their production and use. The European Union is working on one, but the proposal still needs to be finalized.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/RECETOX_Forever_chemicals_as_a_ticking_time_bomb_for_future_generations_prof_Martin_Scheringer_Dr_sc_nat_d473fdcaa8.jpg" alt="RECETOX: prof. Martin Scheringer, Dr. sc. nat." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_RECETOX_Forever_chemicals_as_a_ticking_time_bomb_for_future_generations_prof_Martin_Scheringer_Dr_sc_nat_d473fdcaa8.jpg 231w," sizes="100vw" width="575" height="388"><h5>Professor Scheringer, when did people realize that PFAS are much more dangerous than they were thought to be?</h5>The people at the companies that produced these chemicals must have known. I&nbsp;first learned about it in a&nbsp;paper published in 2001 by J. P. Giesy and K. Kannan. It was a&nbsp;revolutionary publication. J. P. Giesy, by the way, has been working with RECETOX for a&nbsp;long time and he is a&nbsp;member of the International Scientific Advisory Board at RECETOX.<h5>Why are PFAS produced in such huge quantities? Is it because of their unique properties?</h5>Yes, definitely, plus they started to be used in the 1950s, a&nbsp;period full of optimism and development after the Second World War. There was exponential growth in all sectors at that time. However, from the beginning, some people must have known that this was a&nbsp;chemical substance that would be difficult to break down and could cause problems. Take DDT, for example; this was also seen as a&nbsp;'miracle' in agriculture, but even in the 1950s, people could see the side effects on birds, fish, and bees, and it was clear that this substance would cause a&nbsp;great deal of trouble. The problem is that the mindset at that time was that the solution to pollution was dilution.<h5>Many companies, especially outdoor clothing manufacturers, have stopped using PFAS (e.g., in Gore-Tex membranes) on their initiative and replaced it with other chemicals to protect consumers and the environment. Can the chemicals that replace PFAS be relied upon to be safe?</h5><div class="box-content">PFAS is so problematic that most alternatives will be safer or, at least, preferable. At least in terms of persistence, because these alternatives will be degradable more easily than PFAS. PFAS will never degrade in the environment, so anything that has similar properties but can also degrade is a&nbsp;better alternative. Of course, with the need to test their toxicity. Impregnation, for example, can be solved with waxes. Waxes have been used since ancient China when the Chinese used waxed paper as protection against rain. With simple applications or ways, things can be done similarly, with a&nbsp;similar effect or benefit to people. You can buy jackets from which you can smell the wax. Let’s look at the baking paper as another example. I&nbsp;learned from paper manufacturers in Sweden that wood processing could differ significantly. It results in a&nbsp;naturally grease-resistant paper suitable for baking. Then we do not need additives, such as PFAS, in this case, added to baking papers.<h5>That sounds very interesting, but I&nbsp;suppose it would entail significantly increased costs and, consequently, the selling price of the products.</h5></div><div class="box-content">Perhaps a&nbsp;bit, but it wouldn't make much difference. You know, PFAS are costly. They're expensive to produce, so it wouldn't make a&nbsp;noticeable difference to the consumer. But even if the price difference were more substantial, we should be willing to pay for products that do not contain PFAS.</div><div class="box-content"><h5>Recently I&nbsp;read an article about the US military trying to degrade PFAS with super-heated water. Could this approach be applied generally? Are there some possibilities for how to degrade PFAS?</h5></div><div class="box-content">PFAS that cannot be "collected" from the environment cannot be removed either. This is so in most cases. We cannot remove it from rainwater, groundwater, watercourses, and soil. The instances where we can handle PFAS are always under controlled conditions. In the laboratory, we have removed it using high temperatures, aggressive chemicals, or even microbes that can disrupt the stability of the carbon-fluorine bond by the biochemical reaction. Therefore, our concern is with PFAS which, let’s say, have 'escaped,' and we have no way to collect, treat and remove them.</div><div class="box-content"><h5>So, what is the solution for PFAS in underground water supplies?</h5></div><div class="box-content">We can monitor this PFAS, create maps, as has been done in "The Forever Pollution Project," and try to contain and capture the PFAS in these hotspots. But we can never remove everything, and it is a&nbsp;costly process.</div><div class="box-content"><h5>Professor, under what conditions can PFAS get "out" of, for example, a&nbsp;Teflon pan or a&nbsp;waterproof coat? Everyone probably has these items at home; what is the risk?</h5></div><div class="box-content">These are entirely different cases. The Teflon in the pan is relatively safe; it is a&nbsp;polymer, so the concern only arises if people overheat it. However, it is always necessary to look at the life cycle of the manufactured item, that is, its production, use, and disposal. The use phase is the least worrisome for Teflon; the production and disposal phase is problematic. The scandalous case of DuPont in the USA is well known, where large amounts of one particular PFAS were released into the environment from a&nbsp;Teflon production plant. The situation is quite different in the case of PFAS used in coatings, clothing, and footwear. Our skin is constantly in contact with these products, and during friction, PFAS is released and evaporates, thus entering circulation. Landfills and waste are also significant sources of PFAS entering the environment. Waterproof clothing, carpets, furniture, building materials, etc., containing PFAS go to landfills and become an important pollution source.<h5>EPA (Environmental Protection Agency) has stated that PFAS suppresses the immune response in toddlers. How serious is it from your point of view? A&nbsp;growing number of women in the Czech Republic choose to breastfeed their babies for a&nbsp;long time because of the health benefits. At the same time, parents want their children to spend much time outdoors, so they place them in forest nurseries. The children are exposed to various weather and often wear waterproof clothing and shoes because of bad weather. Parents make these decisions in the best interests of the child. So how is it?</h5></div><div class="box-content">This is a&nbsp;tricky question that is very difficult to answer. I&nbsp;am not an expert on human health and human toxicology. PFAS enters developing fetuses from the mother's&nbsp;body. Infants continue to ingest it in the form of breast milk because PFAS is eliminated from the mother's&nbsp;body through breastfeeding. The amount of PFAS in the body of children is higher due to their significantly lower weight compared to an adult. Pollutants such as pesticides, or PFAS, may be present in breast milk at different levels. Even so, breastfeeding is suitable for children for several reasons. It depends on the actual levels of these substances in the mother's&nbsp;body. Of course, the distribution of pollution varies in different areas. As for clothing and footwear, it's&nbsp;also a&nbsp;question of brand reputation. The big brands have followed the discussion about the PFAS, and often aim to eliminate them from their products. So, it depends on which clothes and shoes we buy.<h5>Is there a&nbsp;certificate indicating products that do not contain PFAS?</h5></div><div class="box-content">Yes, there are, but these labels are not controlled and certified, such as in the case of organic food. If anyone has much power in this fight against PFAS, it is the big brands. Big brands can pressure suppliers to only buy their goods with a&nbsp;guarantee that they are PFAS-free. It's&nbsp;a supply chain issue. It depends on the customer's&nbsp;needs, so the manufacturer responds to that and pressures the supplier.<h5>The so-called Stockholm Convention bans three PFAS chemicals. The others still need to be regulated, although a&nbsp;revolutionary proposal is under discussion to ban fluorinated substances in consumer products by 2025. A&nbsp;complete ban could come into force by 2030. For what reason is there no legislation to regulate these substances so far?</h5></div><div class="box-content">That is a&nbsp;tricky but fair question. That is precisely the question we should ask and answer to the public. The PFAS case poses a&nbsp;massive challenge to a&nbsp;regulatory system that needs to prepare for such situations. Let us be aware that acute toxicity to fish or other aquatic organisms, for example, is being investigated, but the reduced immune response in children is not tested for. That will never be tested because such a&nbsp;test would be highly demanding and costly. So, as far as PFAS is concerned, we are always learning more and more information. The testing system works up to a&nbsp;certain point but is imperfect because it does not ask the right questions. Moreover, when it is a&nbsp;substance already on the market, it is difficult to ban it.<h5>3M and DuPont have been the subject of massive scandals and subsequent lawsuits. These companies have been producing forever chemicals, even though they have had secret studies available to them. They performed tests to monitor contamination and other parameters. They probably could suspect how dangerous the substances were. But they chose to remain silent. How do you see it? Do you see a&nbsp;parallel there?</h5>Yes, the story of the oil and gas company Exxon is also very similar. In the 1980s, they could predict very accurately that their products would cause global warming. They anticipated what would happen regarding climate change and temperature rise with impressive accuracy. And the companies making PFAS were in a&nbsp;similar situation: they knew a&nbsp;lot about the hazards of PFAS, but did not share it</div><div class="box-content"><h5>Do you think it can be said that PFAS represent a&nbsp;ticking time bomb for future generations?</h5>Yes, but it depends on the level of PFAS exposure. Moreover, it will be complicated to prove if a&nbsp;health problem is caused by chronic exposure to PFAS, for example, in childhood. But there will be lasting PFAS legacy in many parts of the world.<h5>Each of us is surrounded by a&nbsp;"cocktail" of chemicals at subthreshold levels. These chemicals can come from the air, cosmetics, or food. Is it reasonable to assume that some mixtures containing, for example, PFAS at "safe levels" could affect disease development?</h5>Mixtures are much debated. Regulation always addresses individual chemicals but does not address mixtures. We can say without exaggeration that current chemical regulation is under-protective.<h5>Professor, what should we learn from an exciting conversation with you?</h5>We must inform people that the goal of our work is not to cause consternation or to scare people. We live in a&nbsp;world we have partly created; we must learn to accept that we cannot escape the consequences and burdens of our actions. We all have PFAS in our bodies; how serious it is, we don't know. We are still determining how serious it will be for generations to come. We must accept it instead of fearing the chemistry around and within us. Chemistry can be beneficial, sometimes harmful, but we need it. Let’s motivate our children to study environmental chemistry. Let’s realize you can move things if you are active. If the public pressures politicians, there won't be so much trouble regulating the industry. The solution is not to be afraid but to focus on what you can do to prevent such situations from happening again. Let's&nbsp;not be paralyzed! Yes, our children have PFAS in their bodies, so let's&nbsp;not raise their levels by giving them fast food that is not only unhealthy but is served in packaging that often contains PFAS.Thank you for the excellent talk, and I wish you success in your research.</div></div>

Forever chemicals as a ticking time bomb for future generations?

Article

Application

Scientific article

Interview

Video

RECETOX (Research Centre for Toxic Compounds in the Environment) is an independent department of the Faculty of Science of Masaryk University in Brno, which has been established in 1983. RECETOX is focused on the research and education in cross-cutting area of Environment and Health. It addresses interactions among chemicals, environment, and biological systems, including consequences at local, regional, and global levels.

RECETOX - Centrum pro výzkum toxických látek v prostředí

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In achievement and prestige, the University of Wisconsin–Madison has long been recognized as one of America's great universities. A public, land-grant institution, UW–Madison offers a complete spectrum of liberal arts studies, professional programs and student activities. Spanning 936 acres along the southern shore of Lake Mendota, the campus is located in the city of Madison.

University of Wisconsin-Madison

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Agilent invites you to join our Back to Basics Live Mini Workshop: How ICP-QQQ Works Educational Webinar. Social distancing times can be used to brush up on this great instrument fundamentals.
During the workshop we will cover general theory on ICP-MS and what lead to the development of the ICP-QQQ back in 2012. During each segment, will discuss the different components and will follow with a live instrument demonstration. At the end of the workshop we will open the floor for a Q&amp;A session so please bring your challenging questions for our Applications Scientist Team. Our intention is to help you get the most out of your ICP-MS instrument.
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Presenter: Bert Woods (Application Scientist, Agilent Technologies, Inc.)
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Joined the Agilent ICP-MS team in 2004, with previous employment in the semiconductor industry with Dominion Semiconductor (IBM/Toshiba) and Micron. Bert is a 1997 Chemistry graduate of Radford University in Virginia and an avid Washington DC Sports fan.
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Presenter: Abe Gutierrez (Product Specialist, Agilent Technologies, Inc.)
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Abe is an Agilent Product Specialist with nearly 30 years’ experience with ICP-MS. Abe started as an applications chemist in the semiconductor industry and moved to Agilent/HP in 1996. Abe is a technical resource supporting the Agilent sales organization.
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Agilent Technologies: Back to Basics Mini Workshop: How ICP-QQQ Works

Back to Basics Mini Workshop: How ICP-QQQ Works

General theory on ICP-MS and what lead to the development of the ICP-QQQ back in 2012.

Universities, research labs with interns and others, need analytical tools that are both easy to learn as teaching tools, while being flexible enough to satisfy the needs of a research environment.
We will discuss each of the above techniques and outline the advantages and challenges of each.
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Presenter: Paul Krampitz (Application Scientist, Agilent Technologies, Inc.)
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Paul is a graduate of Bowling Green State University with a Chemistry Bachelor of Science degree. Twenty – five years of Spectroscopy experience mainly Inductively Coupled Plasma (ICP) Spectroscopy as well as ICP-MS and AAS. His experience also includes X-Ray Fluorescence (ED, WD), Laser Ablation, Inorganic Speciation and Microwave Plasma Spectroscopy. Market Segment expertise includes environmental, petrochemical, metallurgical applications.
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Agilent Technologies: Learn Why Atomic Absorption, MicroWave, and ICP Plasma Spectroscopy are the Perfect Tools for Both a Teaching and Research Environment

Learn Why Atomic Absorption, MicroWave, and ICP Plasma Spectroscopy are the Perfect Tools for Both a Teaching and Research Environment

We will discuss each of the above techniques and outline the advantages and challenges of each.

Learn Why Atomic Absorption, MicroWave, and ICP

Event Program:
<ul>
<li>Which thermal characteristics are studied in pharmaceutical industries?</li>
<li>Introduction to thermal analysis techniques</li>
<li>DSC applications – melting, purity, polymorphism, compatibility</li>
<li>Thermo-optical applications – polymorphism and crystal growth</li>
<li>TGA applications – weight loss on drying, shelf life, solvent content, hydration</li>
<li>TMA applications – swelling of film coatings</li>
<li>DMA applications – glass transition of surgical thread</li>
<li>21 CFR Part 11 Compliance</li>
</ul>
Thermal Analysis is a useful tool for investigating pharmaceutical substances for effects such as polymorphism, purity and composition, phase shifts, and stability. The four main techniques of DSC, TGA, TMA, and DMA are ideal for carrying out these investigations over a wide temperature range, from -150 to 1600 °C.
Important Effects and Properties Measured by Thermal Analysis
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<li>DSC: The most important effects that can be analyzed are the melting point, melting range and melting behavior. This technique is also used to determine the heat of fusion, purity, polymorphism, the glass transition, and oxidation stability.</li>
<li>TOA: Thermo-optical analysis is an auxiliary technique that uses visual observation to study melting behavior and polymorphism.</li>
<li>TGA: The main applications are investigating evaporation, desorption and vaporization behavior, thermal stability, decomposition kinetics, and composition.</li>
<li>TMA: Normally used to study the expansion or shrinkage of materials and the glass transition.</li>
<li>DMA: The most sensitive method for characterizing the glass transition of materials.</li>
</ul>
Join the live webinar to discover more and get the opportunity to ask our experts your questions!
Second session: 25. 4. 2024 16:00 CEST
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Presenter: Angela Hammer (Dr. sc. nat. ETH)
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Dr. Angela Hammer received a Ph.D. in Analytical Chemistry (development of immobilized components for the use in ion-selective electrodes based on polyurethane membranes) from the Institute of Organic Chemistry at the Swiss Federal Institute of Technology in Zürich, Switzerland. She then joined Sika Technology AG in Zurich, Switzerland, as an analytical chemist. In 2007, she joined METTLER TOLEDO and has worked there since as an application specialist for Thermal Analysis. In her present position, she uses, teaches, and supports DSC, TGA, TMA, and DMA instruments for the METTLER TOLEDO’s Materials Characterization Group located at the head office in Switzerland.
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Mettler-Toledo: Thermal Analysis of Pharmaceuticals

Thermal Analysis of Pharmaceuticals

Discover Key Techniques for Studying Pharmaceutical Substances.

Event Program
<ul>
<li>Basics of spectroscopy theory and applications</li>
<li>How UV Vis instruments work</li>
<li>Application of Beer-Lambert law</li>
<li>How to measure a sample and record its UV Vis spectra</li>
<li>How to analyze UV Vis spectra using PC software</li>
<li>Good UV Vis practices</li>
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Join our free live webinar and learn good practices for teaching UV Vis spectroscopy. The webinar will combine theory study with a live demo using a UV Vis spectrometer on the lab bench and spectra analysis software on a laptop.
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Presenter: Dr. Friedrich Menges (Owner/ Creator/ Developer at Spectroscopy Ninja)
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Presenter: Dr. Fabian Müller (Product Manager SPG UV/VIS)
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Mettler-Toledo: UV Vis Spectrophotometry for Teaching and Education

UV Vis Spectrophotometry for Teaching and Education

Learn Good Practices for Teaching UV Vis Essentials.

In this training session, the METTLER TOLEDO product managers will address the questions that are most commonly asked in the field. They will talk about weight handling, maintenance of mass comparators, selection of products, elevation dependence of measurements, and many more topics. Additionally, you will have the opportunity to ask your own questions in an open Q&amp;A session at the end.
Key Takeaways
This is a great opportunity for all mass metrologists, as those questions that many others ask might also be of relevance to you. 
Program
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<li>Discover answers to the most frequently asked questions in mass metrology
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<li>Learn more about weight handling, mass comparator maintenance, etc.
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<li>Ask our experts your own questions
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</ul>
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Speaker: Dr. Frederik Eiler (METTLER TOLEDO, Product Manager Metrology Solutions)
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Speaker: Mark Kliebenschädel (METTLER TOLEDO, Product Manager Metrology Solutions)
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Mettler-Toledo: Mass Calibration – Most Frequently Asked Questions

Mass Calibration – Most Frequently Asked Questions

Opportunity for all mass metrologists, as those questions that many others ask might also be of relevance to you.

Join Agilent on the last full-week Tuesday of the month for our complimentary A la Carte Webinar Series.
The webinar will also be available on-demand so you can watch as your schedule allows.
Don&#39;t miss this opportunity to earn CEU credit sponsored by NSH. 
Live Webinar
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<li>May 21, 2024 | 12:00 PM EDT</li>
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On-Demand Available following the live webcast through Friday.
Register once using the form for both live and on-demand. Frozen Section and Immunofluorescence: Principles, Procedures and Pitfalls
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Presenter: Alan Maziarz (Account Manager, Healthcare Diagnostics, Agilent)
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Presenter: Brooke Bentley (Customer Applications Specialist, Diagnostics and Genomics Group, Agilent)
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Agilent: Frozen Section and Immunofluorescence: Principles, Procedures and Pitfalls

Frozen Section and Immunofluorescence: Principles, Procedures and Pitfalls

Principles, Procedures and Pitfalls of Frozen Section and Immunofluorescence

Frozen Section and Immunofluorescence

Traditionally, photometric methods are used to determine the concentration of a specific metal in a process stream. However, metal interferences in photometric methods pose significant challenges, leading to inaccurate readings of target analytes. Online X-ray fluorescence (XRF) is a powerful and efficient technique that offers a solution to these challenges and can be used to monitor multiple analytes simultaneously.
Join this webinar to learn more about the principles of XRF and, for the very first time, see how XRF technology is now available in the 2060 Process Analyzer. Process leaders from industries such as manufacturing, mining and chemical processing are all encouraged to attend for the opportunity to interact with the speakers and ask questions about our newest innovation.
Who should attend?
<ul>
<li>Process Engineers looking to integrate advanced automated solutions into their operations</li>
<li>Quality Control Managers responsible for maintaining product standards and minimizing defects</li>
<li>Production Managers seeking to enhance efficiency and reduce production costs</li>
<li>Plant Managers overseeing the overall production process and quality control</li>
<li>Sustainability and Operations Managers tasked with implementing sustainability practices within their organizations and overseeing the day-to-day operations</li>
<li>R&amp;D Scientists developing innovative applications for process analysis</li>
</ul>
Key learning points
<ul>
<li>Learn about the principles of XRF technology and its advantages in process analysis</li>
<li>Learn how the 2060 XRF Process Analyzer enables real-time monitoring and immediate corrective actions to maintain production quality</li>
<li>Discover applications for XRF in manufacturing, mining and chemical processing and how it benefits different industries</li>
</ul>
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Presenter: Jeroen Zaalberg (Head of Product Management, Metrohm)
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Jeroen Zaalberg joined Metrohm Process Analytics in 2008, and in the 16 years he has been working for the company, he has worked as an application chemist, Product Manager Wet-Chemistry and is currently in the position of Head of Product Management.
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Jeroen has a BSc. in analytical and physical chemistry and has a passion for product development, innovation and strategy. Over the recent years, Jeroen successfully launched several new products in the Metrohm Process Analytics portfolio.
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Presenter: Kraig Kmiotek (Product Manager, Process Wet Chemistry, Metrohm USA)
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Kraig Kmiotek is the Product Manager for Process Wet Chemistry at Metrohm USA and has a Bachelor of Science in Chemistry from Purdue University. Since joining the Process Analytics team, his focus has been on application work, analyzer design and programming and customer and internal training of process analyzers. He is currently responsible for understanding customer requirements, driving product and service development, and strategic product marketing and demand generation.
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Metrohm: Innovating Process Analysis with XRF

Innovating Process Analysis with XRF

 Learn about the principles of XRF and, for the very first time, see how XRF technology is now available in the 2060 Process Analyzer.

In this webinar, Caroline Roe, Managing Director, Cancer and Immunology Core, Vanderbilt University, will give a broad overview of available high-dimensional flow cytometry technologies and reagents, how they work, and an experience-informed breakdown of the strengths and limitations of each technique. She will review considerations for choosing the appropriate high-dimensional flow cytometry technology for a project. In addition, she will provide guidance for those who have experience in one technology and are transitioning to another.
Key topics discussed in this webinar will include:
<ul>
<li>An overview of high-dimensional flow cytometry technologies and reagents</li>
<li>Considerations for choosing the appropriate high-dimensional flow cytometry technology for a project</li>
<li>Guidance for those who are transitioning to a new flow cytometry technology</li>
</ul>
Who should attend?
<ul>
<li>Flow cytometry novices who wish to learn more about high-dimensional flow cytometry</li>
<li>Experienced flow cytometrists who are new to high-dimensional flow cytometry</li>
<li>Anyone seeking to have a deeper understanding of high-dimensional flow technologies</li>
</ul>
Certificate of attendance
All webinar participants can request a certificate of attendance, including a learning outcomes summary, for continuing education purposes.
<blockquote>
Presenter: Caroline E. Roe, MLI (Managing Director, Cancer and Immunology Core, Vanderbilt University)
</blockquote>
<blockquote>
Caroline Roe received her BS.c. in Genetics, Cell Biology, and Development from the University of Minnesota-Twin Cities, and Master of Laboratory Investigation from Vanderbilt University in Nashville, Tennessee, where she has managed the Mass Cytometry Center of Excellence since its inception in 2017. As director of the Cancer and Immunology Core, her focus is on increasing both the standardization and accessibility of cutting-edge cytometry techniques for application across a broad range of basic and translational research projects.
</blockquote>
<blockquote>
Moderator: Charlie Carter (Associate Editor, SelectScience)
</blockquote>

SelectScience: Improving Results Through Better Understanding: A Primer On High-Dimensional Flow Cytometry Technologies And Reagents

Improving Results Through Better Understanding: A Primer On High-Dimensional Flow Cytometry Technologies And Reagents

A broad overview of available high-dimensional flow cytometry technologies and reagents.

A Primer On High-Dimensional Flow Cytometry Technologies

Elemental impurities are trace metals or elements that can be present in pharmaceuticals, impacting product safety and efficacy.
USP General Chapter &lt;232&gt; provides guidelines for controlling elemental impurities in pharmaceuticals, ensuring they meet acceptable levels for human consumption. Compliance with USP &lt;232&gt; is crucial for regulatory approval and maintaining product quality and safety.
Register to attend this Webinar and learn:
<ul>
<li>Elemental impurities as per USP 232/USP 233 and ICHQ3D
</li>
<li>Dive into the innovation that powers USP-232 guidelines
</li>
<li>Agilent&#39;s MH software with Agilent&#39;s complete workflow solutions
</li>
<li>Basic maintenance and early maintenance feedback of ICP-MS
</li>
</ul>
<blockquote>
Presenter: Dr. Kuldeep Sharma (Sales Development Manager - Pharma, Agilent Technologies)
</blockquote>
<blockquote>
Kuldeep Sharma has over 19 years of experience in area/s of Bioanalytical research, Drug metabolism &amp; pharmacokinetics and Pharma regulatory compliance. He has accomplished PhD in Biotechnology. His professional journey covers over 12 years in Analytical research (associated with R&amp;D’s of Zydus Cadila, Lambda, Pliva and Jubilant Biosys) and last 7 years in analytical instruments sales, marketing &amp; business development. With over 21 research articles published in international Journals, He presents convention of continues learning.
</blockquote>
<blockquote>
Presenter: Mr. Radhey Shyam (Application Specialist - Spectroscopy, Agilent Technologies)
</blockquote>
<blockquote>
Radhey Shyam is an Application Scientist responsible for Elemental Spectroscopy Solutions at Agilent Technologies at Centre of Excellence (COE) Lab, Manesar. He has been assisting in the development of new methods and applications, as well as providing training and educational activities for customers across various sectors on spectroscopy solutions and technologies for the past 10+ years. He has authored several publications in international journals. In addition, he has also contributed to global application and solution notes from Agilent, with a focus on spectroscopy Market.&quot;
</blockquote>
<blockquote>
Presenter: Mr. Ankush Sharma (Regional Marketing Program Manager- APAC (Pharma &amp; Biopharma), Agilent Technologies)
</blockquote>
<blockquote>
Ankush Sharma is a seasoned professional with over 12 years of extensive experience in sales and marketing across the pharmaceutical and biopharmaceutical sectors. His professional journey commenced with a strong educational foundation, earning a Master&#39;s degree in Biotechnology. Building upon this knowledge, he furthered his academic pursuits by obtaining a Master&#39;s in Business Administration with a specialization in Sales and Marketing, demonstrating his commitment to blending scientific understanding with strategic business acumen. For the past five years, he has been an integral part of Agilent, serving as the Regional Marketing Program Manager for the India and now Asia-Pacific (APAC) region for Pharma and Biopharma Markets.
</blockquote>

Agilent Technologies: Demystifying USP & ICHQ3D Guidelines for Elemental Impurities

Demystifying USP & ICHQ3D Guidelines for Elemental Impurities

Elemental impurities as per USP 232/USP 233 and ICHQ3D.

Demystifying USP & ICHQ3D Guidelines for Elemental Impuritie

X-ray emission spectroscopy (XES) has wide ranging element-selective chemical sensitivity to characterize valence, spin-state, ligand bonds, and more. New developments in laboratory XES instrumentation enable routine sample testing. In conjunction with laboratory X-ray absorption spectroscopy (XAS), the laboratory XES systems are finding wide ranging applications in environmental science, energy storage, and more.
In this session, we will highlight laboratory XES capabilities in two energy regimes: hard X-ray (4.5-20 keV) and tender X-ray (2-5 keV). Across these regimes, element-selective capabilities enable analysis of 3rd row transition metals, sulfur, phosphorus, and more. Join to learn more about the wide ranging capabilities and applications of X-ray emission spectroscopy.
Key Learning Objectives:
<ul>
<li>Introduction to X-ray Emission Spectroscopy and its unique capabilities for materials characterization.</li>
<li>Detailed look into example applications of laboratory XES.</li>
<li>Overview of new lab-scale XES instrumentation.</li>
<li>Understanding the process of conducting a laboratory XES measurement, including a real-time measurement demonstration.</li>
</ul>
Who Should Attend:
<ul>
<li>Research Scientists from Universities or Industries that routinely perform materials characterization.</li>
<li>Materials Characterization Lab Managers and Users interested in understanding new techniques.</li>
<li>Those interested in element-specific, non-destructive material analysis.</li>
</ul>
<blockquote>
Presenter: Dr. William Holden (CTO and Co-founder, easyXAFS)
</blockquote>
<blockquote>
Presenter: Dr. Zachary Lebens-Higgins (Testing and R&amp;D Manager, easyXAFS)
</blockquote>
<blockquote>
Presenter: Dr. Paul Aronstein (Applications Scientist, easyXAFS)
</blockquote>
<blockquote>
Presenter: Melissa O&#39;Meara (Forensic Science Consultant, C&amp;EN Media Group)
</blockquote>

C&EN: Materials Characterization with Lab X-ray Emission Spectroscopy (XES)

Materials Characterization with Lab X-ray Emission Spectroscopy (XES)

We will highlight laboratory XES capabilities in two energy regimes: hard X-ray (4.5-20 keV) and tender X-ray (2-5 keV).

ICPMS webinars focusing on Academy/Principles | LabRulez ICPMS