<p><strong>Our Library never stops expanding. What are the most recent contributions to LabRulezICPMS Library in the week of 3rd November 2025? Check out new documents from the field of spectroscopy/spectrometry and related techniques!</strong></p><blockquote><p><span style="font-size:20px;">👉 </span><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/library"><span style="font-size:20px;"><strong>SEARCH THE LARGEST REPOSITORY OF DOCUMENTS ABOUT SPECTROSCOPY/SPECTROMETRY RELATED TECHNIQUES</strong></span></a></p></blockquote><blockquote><p><strong>👉 Need info about different analytical techniques?</strong> Peek into <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/library"><strong>LabRulezLCMS</strong></a> or <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library"><strong>LabRulezGCMS</strong></a> libraries.</p></blockquote><p>This week we bring you application notes by <strong>LECO</strong> and <strong>Shimadzu</strong> and poster by <strong>Thermo Fisher Scientific!</strong></p><h3><strong>1. LECO: Determination of Carbon, Hydrogen, and Nitrogen in Biomass</strong></h3><ul><li>Application note</li><li><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/labrulez-bucket-strapi-h3hsga3/CHN_828_CARBON_HYDROGEN_NITROGEN_BIOMASS_203_821_665_bccca204f2.pdf"><strong>Full PDF for download</strong></a></li></ul><p>Carbon, Hydrogen, and Nitrogen determination is part of the ultimate analysis of solid biofuel materials. Determining the content of these elements can help to characterize the materials and provide information that can be utilized in calculating material/energy balances. In addition, this information may be used to calculate efficiencies, as well as emissions potentials, for solid biofuel materials.&nbsp;</p><h4><strong>Instrument Model and Configuration&nbsp;</strong></h4><p>The <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/library?mainauthorItems=24&amp;search=CHN828"><strong>LECO CHN828</strong></a> is a combustion Carbon, Hydrogen, and Nitrogen determinator that utilizes a pure Oxygen environment in a vertical quartz furnace, ensuring complete combustion and superior analyte recovery. Combustion gases are swept from the furnace through an afterburner containing a reagent to scrub Sulfur compounds from the gas stream prior to collection in the ballast volume. The combustion gases are collected in a ballast where they equilibrate and mix before a representative aliquot (3 cm<sup>3</sup> or 10 cm<sup>3</sup> volume) of the gas is extracted and introduced into a flowing stream of inert gas (Helium or Argon) for analysis. The aliquot gas is carried to an infrared cell (IR) for the detection of Carbon (CO<sub>2</sub>) and a thermal conductivity cell (TC) for the detection of Nitrogen (N<sub>2</sub>). A separate portion of the ballast gas is transferred to an IR cell for the detection of Hydrogen (H<sub>2</sub>O).&nbsp;</p><p>Thermal conductivity detectors work by detecting changes in the thermal conductivity of the analyte gas compared to a reference/carrier gas. The greater the difference between the thermal conductivity of the carrier gas and the analyte gas, the greater the sensitivity of the detector. The CHN828 supports either the use of Helium or Argon as the instrument's carrier gas. When used as a carrier gas, Helium provides the highest sensitivity, and the best performance at the lower limit of the Nitrogen range. Argon can also be used as a carrier gas. However, the thermal conductivity difference between Argon and Nitrogen is not as great as the thermal conductivity difference between Helium and Nitrogen, therefore the detector is inherently less sensitive when using Argon as a carrier gas.&nbsp;</p><h4><strong>TYPICAL RESULTS&nbsp;</strong></h4><p>Data was generated utilizing a linear, full regression calibration for Carbon determination, and linear, force through origin calibrations for Hydrogen and Nitrogen determination, using fractional masses (~0.07 g to ~0.15 g) of 502-642 (Lot 1019) LCRM Phenylalanine (65.47% C, 6.74% H, 8.46% N). The calibration was verified using LECO 502-896 (Lot 1003) LCRM EDTA (41.08% C, 5.52% H, 9.58% N). An atmospheric blank was determined using ground sucrose and was utilized to compensate for entrapped atmosphere. A moisture value for the samples was obtained utilizing a LECO TGM800 on the day of analysis and entered into the software to correct for moisture. Results are reported on a dry basis.</p><h3><strong>2. Shimadzu: Ultrasonic Fatigue Test for Hourglass-shaped Metal Test Specimens with Parallel Sections</strong></h3><ul><li>Application note</li><li><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/labrulez-bucket-strapi-h3hsga3/an_01_00889_en_6ce0f2e7e9.pdf"><strong>Full PDF for download</strong></a></li></ul><h4><strong>User Benefits</strong></h4><ul><li>The ultrasonic fatigue tester is capable of testing at a repetition rate of 20 kHz and can complete tests with 109 cycles (1 billion cycles) in only about 14 hours.</li><li>It is possible to test hourglass-shaped test specimens with parallel sections specified in the Chinese National Standard GB/T 43896 “Metallic materials-Very high cycle fatigue-Ultrasonic fatigue test method.”&nbsp;</li></ul><p>Fatigue is a fracture phenomenon caused by repeated loads, even within the elastic region. It is said that about 70 % of structural fracture phenomena are caused by metal fatigue. For most structural steels, there is a fatigue limit where fatigue failure does not occur even after repeated loading if the stress is less than a certain value, and the number of cycles is about 106 to 107. However, in high-strength steels such as chromium molybdenum steel, it is known that fatigue failure occurs in the ultra-high cycle range of 108 to 109 cycles, exceeding 107 cycles, due to inclusions in the material. Therefore, the standard of 107 repetitions as the maximum number of repetitions used in general fatigue tests is not sufficient, and fatigue tests with more than 109 cycles are required. On the other hand, a fatigue test with more than 109 cycles would take more than 3 years at a 10 Hz load. The ultrasonic fatigue tester used in this study is capable of testing at 20 kHz and can complete tests with 109 cycles in about 14 hours, making it ideal for measuring ultra-high cycle fatigue.</p><p><span>&nbsp;</span>In previous reports1,2), we conducted tests on standard hourglass specimens. In November 2024, the National Standard GB/T 43896 of the People's Republic of China (Metallic materials- Very high cycle fatigue-Ultrasonic fatigue test method) was issued, so Shimadzu has added a new dimension calculation function for hourglass-shaped specimens with parallel sections to its USF2000A dedicated software, Super Sonic. In this paper, we introduce an example of measurement of an hourglass-shaped specimen with a parallel section in compliance with GB/T 43896 using SNCM439, a type ofstructuralsteel.</p><h4><strong>Instruments&nbsp;</strong></h4><p>The <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/library?mainauthorItems=1&amp;search=USF-2000A"><strong>USF-2000A</strong></a> was used in this test. Table 1 shows the testing equipment and Fig. 1 shows the test setup. In the ultrasonic fatigue test, a longitudinal wave vibration generated by a piezo actuator causes the specimen to resonate, and stresses are applied to the specimen. The cyclic stress is not measured using a load cell, but is calculated based on the displacement of specimen's end face. In this test, an eddy current displacement meter was used to measure the displacement of the end face.&nbsp;</p><p>In the ultrasonic fatigue test, internal heat generation occurs due to the high repetition rate. According to GB/T 43896, the surface temperature of the high-stress part of specimen is measured, and the specimen temperature during the test is required to be within room temperature +10 °C. In order to suppress the temperature rise of the specimen, an air cooler was employed to blow cooling air onto the heated region, and intermittent operation was performed as described below.</p><h4><strong>Conclusion&nbsp;</strong></h4><p>In these tests, ultrasonic fatigue tests were conducted on SNCM439 hourglass-shaped specimens with a parallel section in accordance with the Chinese National Standard GB/T 43896, “Metallic materials-Very high cycle fatigue-Ultrasonic fatigue test method,” and S-N diagrams were obtained.</p><h3><strong>3. Thermo Fisher Scientific: Benefits of coupling a high-speed laser ablation system to Quadrupole Inductively Coupled Plasma Mass Spectrometry (ICP-MS)</strong></h3><ul><li>Poster</li><li><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/labrulez-bucket-strapi-h3hsga3/po_12348_high_speed_laser_ablation_system_po12348_en_9c310f2096.pdf"><strong>Full PDF for download</strong></a></li></ul><p>Laser Ablation (LA) coupled with ICP-MS is a well-established way to directly analyze solid samples. The main advantages of laser ablation include the ability to avoid lengthy and potentially contamination prone sample preparation protocols and the ability to obtain information about the spatial resolution of an analyte in a sample.&nbsp;</p><p>The interest in so-called mapping techniques has increased in recent years, calling for laser ablation systems to develop methods to improve sample transfer and therefore speed of mapping experiments. New laser-ablation systems dedicated to high-speed mapping are commercially available and can be easily coupled to quadrupole ICP-MS for such applications.</p><p>With the improvement in sample transfer and washout times from laser ablation systems, the time available to analyze discrete packets of sample from a laser pulse is drastically reduced. The limit for lateral resolution using a sequential ICP-MS, such as a quadrupole ICP-MS, is dependent on the dwell times chosen for each measured m/z channel. This has a direct impact on the signal-tobackground ratio achievable for each m/z channel; therefore, a direct impact on the final image contrast for each mapped m/z channel.</p><h4><strong>MATERIALS AND METHODS</strong></h4><h5><strong>Instrumentation&nbsp;</strong></h5><p>A Teledyne Photon Machines Iridia Laser Ablation System fitted with a Cobalt lowdispersion ablation chamber was directly coupled with a <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/products/1206"><strong>Thermo Scientific™ iCAP™ TQ ICP-MS</strong></a>. Data was acquired using <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/products/1489"><strong>Thermo Scientific™ Qtegra™ Intelligent Scientific Data Solution™ (ISDS) Software</strong></a> and processed using Teledyne Photon Machines HDIP Mass Spectrometry Data Analysis Software.</p><h4><strong>CONCLUSIONS&nbsp;</strong></h4><p>Through careful optimization of laser ablation and ICP-MS parameters, it is possible to generate high quality multi-elemental images at a fast rate. The use of new low-dispersion laser ablation cells and aerosol transfer technology is not limited to simultaneous mass spectrometers and is also applicable to sequential scanning mass spectrometers such as Quadrupole ICP-MS.&nbsp;</p><p>The major limitation of coupling low-dispersion Laser Ablation systems to sequential mass spectrometers is the limited number of elements that can be scanned; however, this is offset by the sensitivity and the specificity of, especially, triple quadrupole ICP-MS systems for the reduction of interferences on select analytes.&nbsp;</p><p>Most imaging experiments can be reduced to three or four analytes of interest, and in these cases LA-ICP-MS coupled to Triple Quadrupole ICP-MS using a low-dispersion, fast imaging setup can provide the analytical data quality required to answer challenging research questions.</p>

News from LabRulezICPMS Library - Week 45, 2025

<p><strong>Thirteenth annual Conference of the Czech Society for Mass Spectrometry will take place together with the eleventh Informal Proteomic Meeting from November 19 – November 21, 2025 in České Budějovice.</strong></p><h3><strong>Registration</strong></h3><blockquote><ul><li><strong>Free on-line registration:</strong> Saturday, <strong>March 22 </strong>till Monday, <strong>November 3, 2025</strong></li><li><strong>On-site registration will be available for CZK 2500.</strong></li></ul></blockquote><h3><strong>Program</strong></h3><h4><strong>Wednesday November 19, 2025</strong></h4><h5><strong>10:00 - 18:00 Registration</strong></h5><h5><strong>12:45 - 13:45 &nbsp;</strong>Lunch – Canteen, Biology Centre CAS</h5><h5><strong>13:45 - 14:00 Conference Opening</strong></h5><h5><strong>14:00 - 15:00 Plenary Lecture I: Prof. Alexander Makarov (Thermo Fisher Scientific)&nbsp;</strong></h5><h5><strong>15:00 - 16:00 Session I&nbsp;</strong></h5><h5><strong>15:00 - 15:20 </strong><a target="_blank" rel="noopener noreferrer" href="https://www.czechms.org/cz/events/cmsc/abstract.php?code=8123077"><strong>WeO-01</strong></a><strong>: Towards MS-guided Precision Environmental Health: the Czech node of the European Research Infrastructure for Human Exposome Research</strong></h5><ul><li>Elliott James Price</li></ul><h5><strong>15:20 - 15:40 </strong><a target="_blank" rel="noopener noreferrer" href="https://www.czechms.org/cz/events/cmsc/abstract.php?code=3900926"><strong>WeO-02</strong></a><strong>: Optimization of microflow LC-MS method by design of experiments and its application to proteomics analysis</strong></h5><ul><li>Urban Jiří</li></ul><h5><strong>15:40 - 16:00 </strong><a target="_blank" rel="noopener noreferrer" href="https://www.czechms.org/cz/events/cmsc/abstract.php?code=5590880"><strong>WeO-03</strong></a><strong>: Simultaneous mapping of peptides and released N-glycans by HILIC-FLD-MS for quality control of protein biopharmaceuticals</strong></h5><ul><li>Starovoit Mykyta</li></ul><h5><strong>16:00 - 16:30 Coffee Break</strong></h5><h5><strong>16:30 - 16:50 Sponsor Lecture – </strong><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/companies/51"><strong>Phenomenex</strong></a></h5><h5><strong>16:50 - 18:10 Session II</strong></h5><h5><strong>16:50 - 17:10 </strong><a target="_blank" rel="noopener noreferrer" href="https://www.czechms.org/cz/events/cmsc/abstract.php?code=7077801"><strong>WeO-04</strong></a><strong>: G-quadruplex – ligand interaction biophysics explored by native mass spectrometry and trapped ion mobility spectrometry</strong></h5><ul><li>Melikov Aleksandr</li></ul><h5><strong>16:50 - 17:10 </strong><a target="_blank" rel="noopener noreferrer" href="https://www.czechms.org/cz/events/cmsc/abstract.php?code=4284116"><strong>WeO-05</strong></a><strong>: Insights into CyRepA2 primase-helicase-DNA interactions using structural mass spectrometry</strong></h5><ul><li>Smrčka Tomáš</li></ul><h5><strong>16:50 - 17:10 </strong><a target="_blank" rel="noopener noreferrer" href="https://www.czechms.org/cz/events/cmsc/abstract.php?code=6642100"><strong>WeO-06</strong></a><strong>: Breaking the Unbreakable: Structural Elucidation of the Hypermodified RiPP Nostatin A by IRMPD Mass Spectrometry</strong></h5><ul><li>Hájek Jan</li></ul><h5><strong>16:50 - 17:10 </strong><a target="_blank" rel="noopener noreferrer" href="https://www.czechms.org/cz/events/cmsc/abstract.php?code=4468653"><strong>WeO-07</strong></a><strong>: Unraveling Oligomerization-Mediated Inhibition in GGPPS by Structural Mass Spectrometry</strong></h5><ul><li>Portašiková Jasmína</li></ul><h5><strong>18:10 - 18:30 Sponsor Lecture – Genetica</strong></h5><h5><strong>18:30 - 19:00 Flash Talks I</strong></h5><h5><strong>Quantification of Oxoacids of the Human Metabolome using Liquid Chromatography-Mass Spectrometry </strong><a target="_blank" rel="noopener noreferrer" href="https://www.czechms.org/cz/events/cmsc/abstract.php?code=4124815"><strong>(WeS-01)</strong></a></h5><ul><li>Hebesberger Philipp</li></ul><h5><strong>Analyses of human scent samples </strong><a target="_blank" rel="noopener noreferrer" href="https://www.czechms.org/cz/events/cmsc/abstract.php?code=9840543"><strong>(WeS-02)</strong></a></h5><ul><li>Škeříková Veronika</li></ul><h5><strong>rDUVLAESCI-MS/MSI: a novel approach for direct analysis of biological surfaces </strong><a target="_blank" rel="noopener noreferrer" href="https://www.czechms.org/cz/events/cmsc/abstract.php?code=5983681"><strong>(WeS-03)</strong></a></h5><ul><li>Grepl Jakub</li></ul><h5><strong>Investigation of phenolic compounds in grape pomace through UHPLC-ESI-MS/MS </strong><a target="_blank" rel="noopener noreferrer" href="https://www.czechms.org/cz/events/cmsc/abstract.php?code=8595826"><strong>(WeS-04)</strong></a></h5><ul><li>Jágr Michal</li></ul><h5><strong>Mass Spectral Library Network (MERLIN) To Streamline The Generation Of Public Spectral Libraries </strong><a target="_blank" rel="noopener noreferrer" href="https://www.czechms.org/cz/events/cmsc/abstract.php?code=7046316"><strong>(WeS-05)</strong></a></h5><ul><li>Brigante Federico</li></ul><h5><strong>A Comprehensive timsTOF MS/MS Spectral Library for Improving Metabolite Annotation in Non-Targeted Metabolomics </strong><a target="_blank" rel="noopener noreferrer" href="https://www.czechms.org/cz/events/cmsc/abstract.php?code=5455392"><strong>(WeS-06)</strong></a></h5><ul><li>Mazumdar Aninda</li></ul><h5><strong>19:00 - 22:0 </strong>Welcome Reception &amp; Dinner (Canteen, live music from 19:30)</h5><h4><strong>Thursday November 20, 2025</strong></h4><h5><strong>09:00 - 09:40 Workshop </strong><a target="_blank" rel="noopener noreferrer" href="https://lcms.cz/companies/42"><strong>Pragolab</strong></a></h5><h5><strong>09:40 - 10:40 Session III</strong></h5><h5><strong>09:40 - 10:00 </strong><a target="_blank" rel="noopener noreferrer" href="https://www.czechms.org/cz/events/cmsc/abstract.php?code=5116751"><strong>ThO-08</strong></a><strong>: Low-input proteomics using the Orbitrap Astral</strong></h5><ul><li>Talacko Pavel</li></ul><h5><strong>10:00 - 10:20 </strong><a target="_blank" rel="noopener noreferrer" href="https://www.czechms.org/cz/events/cmsc/abstract.php?code=6944556"><strong>ThO-09</strong></a><strong>: Integrated multiomics classification of triple negative breast cancer</strong></h5><ul><li>Bouchal Pavel</li></ul><h5><strong>10:20 - 10:40 </strong><a target="_blank" rel="noopener noreferrer" href="https://www.czechms.org/cz/events/cmsc/abstract.php?code=5588120"><strong>ThO-10</strong></a><strong>: Proteomics of human breast milk</strong></h5><ul><li>Konik Peter</li></ul><h5><strong>10:40 - 11:00 Sponsor Lecture – Amedis</strong></h5><h5><strong>11:00 - 11:30 </strong>Coffee Break</h5><h5><strong>11:30 - 12:10 Workshop Genetica</strong></h5><h5><strong>12:10 - 13:10 Session IV</strong></h5><h5><strong>12:10 - 12:30 </strong><a target="_blank" rel="noopener noreferrer" href="https://www.czechms.org/cz/events/cmsc/abstract.php?code=5278447"><strong>ThO-11</strong></a><strong>: Development-dependent molecular strategies of stress adaptation in plants</strong></h5><ul><li>Černý Martin</li></ul><h5><strong>12:30 - 12:50 </strong><a target="_blank" rel="noopener noreferrer" href="https://www.czechms.org/cz/events/cmsc/abstract.php?code=4462363"><strong>ThO-12</strong></a><strong>: Deciphering adaptive shifts in the redox proteome of wheat seedlings under drought</strong></h5><ul><li>Danchenko Maksym</li></ul><h5><strong>12:50 - 13:10 </strong><a target="_blank" rel="noopener noreferrer" href="https://www.czechms.org/cz/events/cmsc/abstract.php?code=7250720"><strong>ThO-13</strong></a><strong>: No Mark, No Problem: Alternative Epigenetic Silencing in Algae</strong></h5><ul><li>Lochmanová Gabriela</li></ul><h5><strong>13:10 - 14:00 </strong>Lunch</h5><h5><strong>14:00 - 14:50 Plenary Lecture II: Prof. Bernhard Kuster (Technical University of Munich)&nbsp;</strong></h5><h5><strong>14:50 - 15:40 Flash Talks II</strong></h5><h5><strong>Propionic acid boosts sensitivity in high-flow RPLC-MS proteomics compared to formic and acetic acid </strong><a target="_blank" rel="noopener noreferrer" href="https://www.czechms.org/cz/events/cmsc/abstract.php?code=3643222"><strong>(ThS-07)</strong></a></h5><ul><li>Lenčo Juraj</li></ul><h5><strong>Towards Biomarker Discovery: Multiomics analysis of Endometriosis </strong><a target="_blank" rel="noopener noreferrer" href="https://www.czechms.org/cz/events/cmsc/abstract.php?code=8104565"><strong>(ThS-08)</strong></a></h5><ul><li>Oždian Tomáš</li></ul><h5><strong>Integrated proteogenomic analysis identifies synuclein gamma as a key target of the mesenchymal stem-like subtype of triple negative breast cancer </strong><a target="_blank" rel="noopener noreferrer" href="https://www.czechms.org/cz/events/cmsc/abstract.php?code=6375703"><strong>(ThS-09)</strong></a></h5><ul><li>Šimoník Jan</li></ul><h5><strong>Human IMPs: A tool for comparing outputs of different tools for transmembrane segment predictions in the human proteome </strong><a target="_blank" rel="noopener noreferrer" href="https://www.czechms.org/cz/events/cmsc/abstract.php?code=5382082"><strong>(ThS-10)</strong></a></h5><ul><li>Vít Ondřej</li></ul><h5><strong>LC-MS/MS-based terminomics unravels role of carboxypeptidase B1 in luminal A breast cancer </strong><a target="_blank" rel="noopener noreferrer" href="https://www.czechms.org/cz/events/cmsc/abstract.php?code=6248138"><strong>(ThS-11)</strong></a></h5><ul><li>Lapčík Petr</li></ul><h5><strong>Mass spectometry in hands of experimental biology: Impaired nucleotide salvage affects de novo synthesis in Drosophila melanogaster </strong><a target="_blank" rel="noopener noreferrer" href="https://www.czechms.org/cz/events/cmsc/abstract.php?code=9618906"><strong>(ThS-12)</strong></a></h5><ul><li>Sysel Jakub</li></ul><h5><strong>Bioaccumulation of pharmaceuticals in herbivorous fish: The role of aquatic plants as a dietary source </strong><a target="_blank" rel="noopener noreferrer" href="https://www.czechms.org/cz/events/cmsc/abstract.php?code=5574795"><strong>(ThS-13)</strong></a></h5><ul><li>Hinterholzová Helena</li></ul><h5><strong>LC-HRMS for large-scale chemical exposure studies </strong><a target="_blank" rel="noopener noreferrer" href="https://www.czechms.org/cz/events/cmsc/abstract.php?code=8545306"><strong>(ThS-14)</strong></a></h5><ul><li>Koudelka Štěpán</li></ul><h5><strong>15:40 - 17:00 </strong>Poster session + Coffee Break</h5><h5><strong>17:00 - 17:40 Workshop Bruker</strong></h5><h5><strong>17:40 - 18:00 Award Lecture – Prof. Josef Chmelík Prize Laureate&nbsp;</strong></h5><h5><strong>18:00 - 18:20 General Assembly of the Czech Society for Mass Spectrometry (in Czech, lecture room)</strong></h5><h5><strong>18:00 - 18:20 Informal meeting of Proteomic section of CSBMB (in Czech or English, poster room)</strong></h5><h5><strong>19:00 - 22:00 </strong>Gala Dinner – Restaurace Solnice</h5><h5><strong>21:00 Optional guided Walk-through historic center of České Budějovice – meet near the Samson's fountain at the main square</strong></h5><h4><strong>Friday November 21, 2025</strong></h4><h5><strong>09:00 - 09:50 Plenary Lecture III: Prof. Jana Roithová (Radboud University)</strong></h5><h5><strong>09:50 - 10:50 Session V</strong></h5><h5><strong>09:50 - 10:10 </strong><a target="_blank" rel="noopener noreferrer" href="https://www.czechms.org/cz/events/cmsc/abstract.php?code=2187982"><strong>FrO-15:</strong></a><strong> Per- and polyfluorinated compounds (PFAS) in wild common bream</strong></h5><ul><li>Grabicová Kateřina</li></ul><h5><strong>10:10 - 10:30 </strong><a target="_blank" rel="noopener noreferrer" href="https://www.czechms.org/cz/events/cmsc/abstract.php?code=8460763"><strong>FrO-16:</strong></a><strong> Spatial mapping of 15N-labeled ammonia with MALDI-FTICR imaging in regenerating liver tissue: Re-directing of toxic byproduct into anabolic pathways</strong></h5><ul><li>Kučera Lukáš</li></ul><h5><strong>10:30 - 10:50 </strong><a target="_blank" rel="noopener noreferrer" href="https://www.czechms.org/cz/events/cmsc/abstract.php?code=5845173"><strong>FrO-17</strong></a><strong>: LC-ICP-MS analysis of anti-obesity peptides and their metabolites labeled with lanthanide mass-tag</strong></h5><ul><li>Čechová Aneta</li></ul><h5><strong>10:50 - 11:00 Sponsor Lecture – Shimadzu</strong></h5><h5><strong>11:00 - 11:20 </strong>Coffee break</h5><h5><strong>11:20 - 11:40 Sponsor Lecture – Bruker</strong></h5><h5><strong>11:40 - 13:00 Session VI</strong></h5><h5><strong>11:40 - 12:00 </strong><a target="_blank" rel="noopener noreferrer" href="https://www.czechms.org/cz/events/cmsc/abstract.php?code=3584762"><strong>FrO-18</strong></a><strong>: Advancing Gut Microbiome Metabolomics: A Derivatization-Based Approach</strong></h5><ul><li>Stefani Tommaso</li></ul><h5><strong>12:00 - 12:20 </strong><a target="_blank" rel="noopener noreferrer" href="https://www.czechms.org/cz/events/cmsc/abstract.php?code=1987314"><strong>FrO-19</strong></a><strong>: Mass Spectrometry in Drug Development: From Screening to Stability and Pharmacokinetics</strong></h5><ul><li>Chalupský Karel</li></ul><h5><strong>12:20 - 12:40</strong><a target="_blank" rel="noopener noreferrer" href="https://www.czechms.org/cz/events/cmsc/abstract.php?code=7700719"><strong> FrO-20</strong></a><strong>: Mass spectrometry of human body odor: Signatures of psychophysiological states</strong></h5><ul><li>Kyjakova Pavlina</li></ul><h5><strong>12:40 - 13:00 </strong><a target="_blank" rel="noopener noreferrer" href="https://www.czechms.org/cz/events/cmsc/abstract.php?code=7256314"><strong>FrO-21:</strong></a><strong> Population-scale human chemical exposomics by automated liquid-liquid extraction coupled to gas chromatography – Orbitrap mass spectrometry</strong></h5><ul><li>Coufalíková Kateřina</li></ul><h5><strong>13:00 - 13:10 Closing Remarks and Awards</strong></h5><h5><strong>13:10 - 14:00 </strong>Lunch</h5><h5><strong>14:00 - 17:40 Guided Tour – Samson Brewery / Temelín Nuclear Power Plant</strong></h5>

Program of the 13th Conference of Czech Mass Spectrometry together with 11th Informal proteomic meeting

<p><strong>An international team of scientists from three continents led by Dr. Petr Cígler of IOCB Prague has developed a method for creating light-emitting quantum centers in nanodiamonds in only a matter of minutes. In just one week, the process can yield as much material as conventional methods would produce in more than forty years. Moreover, the resulting nanodiamonds show improved optical and quantum properties. The breakthrough brings us one step closer to the industrial production of higher-quality and more affordable quantum nanodiamonds, which have broad applications in research and technology. The article was published in the scientific journal </strong><i><strong>Advanced Functional Materials</strong></i><strong>.</strong></p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Tomas_Bellon_UOCHB_Dr_Petr_Cigler_vedouci_vedecke_skupiny_Synteticka_nanochemie_a_Dr_Michal_Gulka_prvni_autor_studie_7eacae6a92.jpg" alt="omáš Belloň/IOCB Prague: Dr. Petr Cígler, head of the Synthetic Nanochemistry research group, and Dr. Michal Gulka, first author of the study" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Tomas_Bellon_UOCHB_Dr_Petr_Cigler_vedouci_vedecke_skupiny_Synteticka_nanochemie_a_Dr_Michal_Gulka_prvni_autor_studie_7eacae6a92.jpg 234w," sizes="100vw" width="1600" height="1068"></p><p>The research team has introduced a <strong>new procedure </strong>called <strong>Pressure and Temperature Qubits (PTQ)</strong>, which takes only four minutes. Diamond powder is placed in a press that generates extremely high pressure and temperature, reproducing the conditions found deep within the Earth’s mantle. Under these conditions, quantum centers are formed inside the nanodiamonds. To prevent the particles from fusing together, ordinary table salt is added. It melts during heating, creating a protective environment. After the process, the salt is simply removed with water, leaving a pure, luminescent material.</p><p>“<i>We’ve accelerated the creation of quantum centers in nanodiamonds more than a thousandfold compared with the standard procedure. Until now, diamond powder had to be irradiated with a beam of charged particles for two weeks and then annealed at high temperature. The result was less than a gram of usable material. We can now produce it in kilograms,</i>” says Dr. Michal Gulka, a postdoctoral researcher in <strong>Petr Cígler’s group </strong>and first author of the study.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/UOCHB_Pristroj_ve_kterem_se_svitive_nanodiamanty_pripravovaly_760291e866.jpg" alt="IOCB Prague: The apparatus in which the luminescent nanodiamonds were prepared." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_UOCHB_Pristroj_ve_kterem_se_svitive_nanodiamanty_pripravovaly_760291e866.jpg 241w," sizes="100vw" width="1600" height="1036"></p><p><strong>Nanodiamonds</strong> are particles smaller than a virus that are used in advanced diagnostics to measure magnetic fields, charge, or temperature. They function as highly sensitive sensors thanks to a <strong>nitrogen-vacancy (NV) center</strong> – a nitrogen atom located next to a missing carbon atom in the diamond lattice. The NV center is fluorescent, meaning that when illuminated, it emits light. The intensity and timing of this light depend on changes in the surrounding environment, allowing nanodiamonds to detect even individual molecules or measure temperature inside cells.</p><p>A key contributor to the project is the <strong>American company MegaDiamond</strong>, which plans to launch industrial production of these nanosensors.</p><p>“<i>Thanks to the new method, laboratories and companies around the world can obtain large quantities of high-quality nanodiamonds with NV centers, which opens the door to new technologies – from precision sensors for medical diagnostics to local molecular detectors based on principles such as magnetic resonance,</i>” adds Dr. Petr Cígler.</p><p>The study was supported in part by the <strong>AMULET project</strong>, which focuses on developing multiscale nanomaterials and brings together eight partners led by the J. Heyrovský Institute of Physical Chemistry. Funding was provided through the Jan Amos Komenský Operational Programme of the Czech Ministry of Education, Youth and Sports, under the Excellent Research category.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/IOCB_Prague_The_standard_procedure_for_creating_NV_ac77f62eb5.jpg" alt="IOCB Prague: The standard procedure for creating NV (nitrogen vacancy) quantum centers in nanodiamonds involves costly irradiation in particle accelerators and annealing. It is both laborious and time-consuming. The new method, which uses plastic deformation under extremely high temperature and pressure, produces both red-emitting NV centers and green-emitting H3 centers. Moreover, it repairs the diamond lattice, resulting in particles with a more stable charge state, higher magnetic resonance (MR) contrast, and improved spin properties of the NV centers, which enables more sensitive and accurate measurements." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_IOCB_Prague_The_standard_procedure_for_creating_NV_ac77f62eb5.jpg 245w," sizes="100vw" width="1500" height="688"></p><blockquote><h4><strong>The original article</strong></h4><h4><a target="_blank" rel="noopener noreferrer" href="https://advanced.onlinelibrary.wiley.com/doi/10.1002/adfm.202520907"><strong>Quantum‐Grade Nanodiamonds from a Single‐Step, Industrial‐Scale Pressure and Temperature Process</strong></a></h4><p>Yahua Bao, Michal Gulka, Parkarsh Kumar, Jakub Copak, Priyadharshini Balasubramanian, Yuliya Mindarava, Rémi Blinder, Michael Olney-Fraser, Haotian Wen, Hana Spanielova, Helen Zhi Jie Zeng, Benjamin Whitefield, Igor Aharonovich, Jaroslav Hruby, Fedor Jelezko, J. Daniel Belnap, Shery L. Y. Chang, Petr Cigler</p><p>Adv. Funct. Mater. 2025</p><p><a target="_blank" rel="noopener noreferrer" href="https://doi.org/10.1002/adfm.202520907">https://doi.org/10.1002/adfm.202520907</a>&nbsp;</p></blockquote>

IOCB Prague unveils a fundamentally faster, more affordable way to produce quantum-grade nanodiamonds

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The relatively new tradition of the Czech mass spectrometry conferences was established only in 2011, the very first event took place in Hradec Králové. Since then, the conference was organized every year except for 2020, the year of the pandemic.

Czech Mass Spectrometry Conferences

The Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences (IOCB Prague) is a leading scientific institution in the Czech Republic, recognized internationally. Its primary mission is basic research in the fields of chemical biology and medicinal chemistry, organic and material oriented chemistry, chemistry of natural compounds, biochemistry and molecular biology, physical chemistry, theoretical chemistry, and analytical chemistry. 

Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences

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13th Conference of Czech Mass Spectrometry together with 11th Informal proteomic meeting

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IOCB Prague unveils a fundamentally faster, more affordable way to produce quantum-grade nanodiamonds

Program of the 13th Conference of Czech Mass Spectrometry together with 11th Informal proteomic meeting

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