Streamlining NMR Spectrometer Usage, a Use-Case of SmartDriveNMR for Pharmaceutical Industry

Optimization of costly NMR spectrometer acquisition time while maintaining short turnaround times are of peculiar importance for analytical services, usually dealing with large number of samples. For structural analysis, a significant step was achieved with the use of Non-Uniform Sampling (NUS) for 2D acquisition on a routine basis. Now, with the introduction of a tool like SmartDriveNMR, further optimization in full automation is possible to find to find the optimal acquisition parameters for the desired spectral quality.

Selecting the appropriate NMR acquisition parameters to ensure adequate spectral quality while limiting the acquisition time has always been a challenge in NMR, requiring training and experience. Non-Uniform Sampling was a significant milestone to limit acquisition time, yet it also even complicated parameter selections. Without prior scouting analysis, even advanced user may fail, ending up with low quality data and/or wasting spectrometer time.

To try to tackle these challenges, Evotec ID Lyon has implemented SmartDriveNMR for its routine structural analysis workflows. This webinar will present this use case, towards automated, failsafe on-the-fly optimization of NMR acquisition for structural analysis.

Key Learning Topics

• Implementation of SmartDriveNMR as the primary tool for structural analysis in an industrial Analytical Service
• Customization and optimization for the user’s needs
• Feedback after more than 1 year of routine use, benefits and shortcomings

Who should attend

This webinar will be of interest to people who own or work with AVANCE Neo but also AVANCE 3 for liquid state NMR with any kind of sample changer.

Presenter: Dr. Valentin Poirier (Senior Research Scientist at Evotec (ID) Lyon)

Valentin Poirier holds a PhD in chemistry from the University of Rennes, focused on organometallic catalysis and polymers. He then joined the pharmaceutical industry and pivoted to the analytical field, focusing on NMR and MS. After several years managing the analytical platform of a CRO he joined Evotec ID Lyon in 2021 as the head of the local Analytical Chemistry Department.

Presenter: Dr. Bjoern Heitmann (Product Manager for SmartDriveNMR at Bruker BioSpin)

Studied physics at both undergraduate and PhD level, with his postgraduate studies focused around protein NMR. Since then, Bjoern has undertaken multiple postdoc positions before joining Bruker BioSpin in the R&D department. Bjoern has been with Bruker since 2006 and currently heads the Software R&D department.