A team led by Prof. Jan Konvalinka has developed a compound that destroys the yeast Cryptococcus neoformans – a fungus which is life-threatening for people with weakened immune systems – in laboratory settings. Researchers at IOCB have created a new method for synthesizing macrocyclic compounds – small, ring-shaped molecules. Using this approach, they discovered a highly promising compound that kills the fungus in lab cultures, does not harm human cells, and is effectively entering the bloodstream when administered orally, as demonstrated in mice. The study was published in the Journal of Medicinal Chemistry.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/UOCHB_Vedci_z_UOCHB_kroti_houbu_ktera_je_smrtelne_nebezpecna_pro_pacienty_s_oslabenou_imunitou_db767d28f8.jpg" alt="IOCB Prague: Researchers tame a deadly fungus that threatens immunocompromised patients: Simplified chemical scheme of the synthesis of macrocyclic inhibitors, which give rise to orally available antifungal compounds. The new method enables the assembly of small cyclic molecules directly on a solid support, allowing for the creation of an entire library of candidate compounds much faster than before. X-ray structural analysis shows how compound 25 fits into the pocket of the active site of the target enzyme Major Aspartyl Peptidase 1, thereby blocking its activity and limiting the growth of yeast." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_UOCHB_Vedci_z_UOCHB_kroti_houbu_ktera_je_smrtelne_nebezpecna_pro_pacienty_s_oslabenou_imunitou_db767d28f8.jpg 245w," sizes="100vw" width="1992" height="621">The head of the <a target="_blank" rel="noopener noreferrer" href="https://konvalinka.group.uochb.cz/en">research group</a> behind the discovery and the director of IOCB Prague, Jan Konvalinka, emphasizes that this was an exceptional collaboration.“The authorship team is particularly interesting. The first author of the study, Robin Kryštůfek, joined my lab already during his high school studies, and the second author, Václav Verner, only recently graduated from secondary school. Working with such students is truly a pleasure,” says Professor Konvalinka.<div>Cryptococcus causes a disease known as cryptococcosis. The yeast enters the body through the respiratory tract and can reach the brain, leading to meningitis in transplant patients or people with AIDS – a frequently fatal complication for those with compromised immune systems. The fungus is commonly found in pigeon droppings and spreads through the air.The IOCB team focused on a particularly problematic variant of this fungus: C. neoformans. This strain is more insidious and aggressive due to an enzyme called May1 aspartic protease. The enzyme subtly alters the fungal cell wall, helping the pathogen evade the host's immune response and survive in hostile environments.“We’re essentially trying to muzzle the protease so it can’t help the cryptococcal cells ‘change their coats’ and hide from the immune system,” explains Robin Kryštůfek, PhD student and first author of the study. “Once the enzyme is blocked, the immune system can detect and eliminate the fungus on its own.”To this end, the team developed a new series of macrocyclic compounds designed specifically to inhibit the May1 enzyme. Their entirely novel approach allowed them to generate a full library of molecules. Previously, macrocyclic inhibitors had to be synthesized one by one in a complicated process – something now made obsolete by this breakthrough.“Our key contribution is that we managed to synthesize a large number of inhibitors simultaneously,” Kryštůfek adds. “This enabled us to discover two compounds that enter the systemic circulation in mice after simple oral administration.”The most promising of these (Compound 25) functions by fitting into the active site of the target enzyme like a perfect puzzle piece. Its unique shape enhances both the strength and specificity of binding. As a result, the compound is less likely to interfere with other proteins in the body and less likely to be toxic.</div><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/UOCHB_Vedci_z_UOCHB_kroti_houbu_ktera_je_smrtelne_nebezpecna_pro_pacienty_s_oslabenou_imunitou_2_2abb82df77.jpg" alt="IOCB Prague: Researchers tame a deadly fungus that threatens immunocompromised patients: Growth charts of yeast cultures of Cryptococcus neoformans under various conditions. Growth analysis revealed that certain concentrations of the newly discovered compounds 9 and 25 slow down yeast growth comparably to clinically used drugs." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_UOCHB_Vedci_z_UOCHB_kroti_houbu_ktera_je_smrtelne_nebezpecna_pro_pacienty_s_oslabenou_imunitou_2_2abb82df77.jpg 245w," sizes="100vw" width="1342" height="656">

Researchers tame a deadly fungus that threatens immunocompromised patients

Our Library never stops expanding. What are the most recent contributions to LabRulezICPMS Library in the week of 7th July 2025? Check out new documents from the field of spectroscopy/spectrometry and related techniques!<blockquote>👉 <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/library">SEARCH THE LARGEST REPOSITORY OF DOCUMENTS ABOUT SPECTROSCOPY/SPECTROMETRY RELATED TECHNIQUES</a></blockquote><blockquote>👉 Need info about different analytical techniques? Peek into <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/library">LabRulezLCMS</a> or <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library">LabRulezGCMS</a> libraries.</blockquote>This week we bring you brochure by Anton Paar, poster by Shimadzu / ASMS and application note by Thermo Fisher Scientific!<h3>1. Anton Paar: Dynamic Shear Rheometers for Asphalt SmartPave</h3><ul><li>Brochure</li><li><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/labrulez-bucket-strapi-h3hsga3/C92_IP_013_EN_K_Brochure_Smart_Pave_screen_dda7b47acc.pdf">Full PDF for download</a></li></ul>The SmartPave brochure introduces a family of dynamic shear rheometers (DSR) – <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/library?mainauthorItems=444&amp;search=SmartPave+92">SmartPave 92</a>, <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/library?mainauthorItems=444&amp;search=SmartPave+102e">SmartPave 102e</a>, and<a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/library?mainauthorItems=444&amp;search=+MCR+502e+Power"> MCR 502e Power</a> – specifically developed for the demanding rheological characterization of asphalt binders and bitumen. These instruments meet international standards such as AASHTO, ASTM, DIN EN, and others, and support a wide temperature range, enabling tests for routine quality control, research, and advanced performance grading.Each SmartPave system is equipped with innovative features like EC motors for high-precision torque control, Toolmaster™ for automatic tool recognition, and TruRay™ sample illumination. The Peltier-based temperature control – with heating from both above and below – ensures fast, accurate, and stable temperature conditions without water circulation. This allows fully dry operation, which is particularly important for repeatable and noise-free measurements.The brochure outlines various standard and advanced testing methods, such as Superpave PG grading (AASHTO T315), MSCR tests (AASHTO T350), viscosity measurements (ASTM D4402), and GTR-modified asphalt analysis. Advanced applications include DMA on solid asphalt, master curves, and low-temperature measurements down to –160 °C. The modular system supports multiple geometries including parallel-plate, cone-plate, and concentric-cylinder setups.All systems operate with the <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/library?mainauthorItems=444&amp;search=RheoCompass+software">RheoCompass® software</a>, offering intuitive test design, automated calibration, standard operating procedures (SOPs), and customizable analysis. This makes SmartPave systems ideal for both routine lab use and advanced asphalt R&amp;D, offering unmatched performance, ease of use, and compliance with global asphalt testing standards.<h3>2. Shimadzu / ASMS: Arsenic Speciation in Rice and Rice Products using LC-ICP-MS: A Sensitive and Reliable Approach by Shimadzu&nbsp;</h3><ul><li>Poster</li><li><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/labrulez-bucket-strapi-h3hsga3/ASMS_2025_THP_065_99cfe0ebbb.pdf">Full PDF for download</a></li></ul>Arsenic toxicity is a major public health concern, particularly in drinking water, leading to strict regulatory limits worldwide. While total arsenic has traditionally been measured, its toxicity largely depends on its chemical form with inorganic species Arsenite and Arsenate (As(III) and As(V)) being highly toxic and carcinogenic, and organic forms monosodium methyl arsenate (MMA) and disodium methyl arsenate (DMA) displayed in fig. 1, considered less harmful. Speciation analysis is therefore essential for accurate risk assessment.&nbsp;Rice and rice-based products are of particular concern, as rice can efficiently accumulate inorganic arsenic from the environment. In response, the European Union established maximum residue levels (MRLs) for inorganic arsenic in rice under Commission Regulation (EU) 2015/1006, highlighting the need for precise speciation.&nbsp;To address this, advanced techniques like liquid chromatography coupled with inductively coupled plasma mass spectrometry (LC-ICPMS) are employed. LC-ICPMS provides high sensitivity and specificity for arsenic species determination, ensuring regulatory compliance and protecting consumer health.&nbsp;This study presents the effective use of Shimadzu’s <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/library?mainauthorItems=1&amp;search=LC-ICPMS-2050+LF">LC-ICPMS-2050 LF</a> system for arsenic speciation in rice and related products.<h4>Methods and Materials</h4>All standard stock solutions are prepared as specified in the LC-ICP-MS Method Package for Arsenic Speciation Analysis Type-2 by Shimadzu, Japan. Seven levels of mixed calibration standards are prepared and injected for the quantification of arsenic species. Calibration curves are generated using the external standard calibration method with a 1/l weighted regression. All samples are prepared in duplicate to verify method performance. Additionally, two spiked samples containing only inorganic arsenic standards are included to evaluate the extraction efficiency of the method.&nbsp;The Shimadzu <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/library?mainauthorItems=1&amp;search=ICPMS-2050+LF">ICPMS-2050 LF</a>, coupled with the Nexera LC series (Fig. 2), manufactured by Shimadzu Corporation, Japan, is used to separate and quantify the different arsenic species present in the samples.<h4>Conclusion&nbsp;</h4><ul><li>The extraction procedure employed effectively ensures the recovery of inorganic and organic arsenic species from various sample types, including both raw and processed materials.&nbsp;</li><li>A highly sensitive method based on hyphenated techniques, specifically LC-ICPMS, is developed for the speciation and quantification of arsenic using the Shimadzu ICPMS-2050 LF coupled with a Nexera inert LC system.</li></ul><h3>3. Thermo Fisher Scientific: EDXRF analysis of coal fly ash as loose powders Ling Yok Ung, Application Specialist</h3><ul><li>Application note</li><li><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/labrulez-bucket-strapi-h3hsga3/edxrf_analysis_of_coal_fly_ash_as_loose_powders_an41971_en_2960bf7ad9.pdf">Full PDF for download</a></li></ul>All the waste that remains after coal is burned, often in a coalfired power station, is referred to as coal ash. Coal ash may contain lead, mercury, arsenic and many other heavy metals. Fly ash and bottom ash are two subcategories of coal ash, typically separated based on particle size.&nbsp;More than half of coal leftovers are fly ash, the most abundant and well-known component. Particles of fly ash, the lightest type of coal ash, “fly” up into a power plant’s exhaust stacks because they are so light. About 99 % of the ash are captured by filters inside the stacks, which draw it in with opposing electrical charges. Fly ash can be recycled. The fine particles are a perfect material for wallboard and concrete because they bond together and solidify, especially when combined with water.&nbsp;But fly ash from coal is also a dangerous industrial solid waste. The natural environment and human health are seriously threatened by its excessive worldwide production, inappropriate disposal methods, underutilization, and lack of knowledge about its inherent risks. Therefore, a method that is quick, precise, and accurate, is required to quantify coal fly ash. Many companies use X-ray fluorescence spectrometry (XRF) as a preferred technology for process and quality control since it is a proven analytical approach that can accurately assess the chemical composition of materials with limited sample preparation.<h4>Instrumentation&nbsp;</h4>The <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/products/1209">Thermo Scientific™ ARL™ QUANT’X EDXRF Spectrometer</a> is equipped with a Silicon Drift Detector (SDD) and a 50 Watt Rh or Ag target X-ray tube which is air cooled with a maximum excitation v The Thermo Scientific™ ARL QUANT’X™ EDXRF Spectrometer is equipped with the following features: and radiation of heat in our atmosphere; N2 and O2 which are present in much higher concentrations do not have this same characteristic effect. Atmospheric CO2 levels increase the temperature of the surface of our planet, simultaneously excess CO2 is dissolved into the oceans gradually lowering the water’s pH, thus making the seas more acidic.&nbsp;<ul><li>Silicon drift detector (SDD): The SDD remains the performance benchmark for all energy dispersive detectors. The large active area of 30 mm² enables effective capture of characteristic element X-rays emitted by the sample.&nbsp;</li><li>50 W Rh or Ag target X-ray tube: Air-cooled with a maximum excitation voltage of 50 kV.&nbsp;</li><li>Nine primary beam filters: Designed to optimize the peak-to-background signals for all elements from F to Am.&nbsp;</li><li>10-Position auto-sampler with spinner: Allows for unattended analysis of multiple samples.</li></ul><h4>Conclusion&nbsp;</h4>This application note shows the suitability of the ARL QUANT’X EDXRF Spectrometer for the analysis of coal fly ash samples. This compact instrument allows for reliable and fast analysis of coal fly ash. Accuracy and repeatability results show that satisfactory results are obtainable for an analysis of loose powder in vacuum. This is a significant advantage for simple sample preparation while providing good accuracy &amp; precision.

News from LabRulezICPMS Library - Week 28, 2025

Structural biologist Pavel Plevka from the CEITEC research centre at Masaryk University (MUNI) has been elected a new member of the prestigious European Molecular Biology Organization (EMBO). This elite organisation, with a history spanning more than sixty years, annually elects outstanding scientists in the field of life sciences based on international recognition of their research and long-term contributions to the scientific community. Brno has every reason to be proud.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/CEITEC_Pavel_Plevka_z_CEITEC_byl_zvolen_mezi_evropskou_vedeckou_elitu_2_fde094fcd3.jpg" alt="CEITEC: Pavel Plevka from CEITEC Elected Among Europe’s Scientific Elite" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_CEITEC_Pavel_Plevka_z_CEITEC_byl_zvolen_mezi_evropskou_vedeckou_elitu_2_fde094fcd3.jpg 235w," sizes="100vw" width="1600" height="1067"><a target="_blank" rel="noopener noreferrer" href="https://www.embo.org/">EMBO</a> brings together over 2,100 researchers from across Europe and beyond. Its members include Nobel Prize laureates and other prominent scientists who shape the direction of research in areas such as genetics, cell biology, developmental biology, and structural biology.At CEITEC MUNI, Pavel Plevka specialises in structural biology – a field that reveals the shapes and behaviours of the molecules of life at atomic resolution. His research focuses on the structures of viruses and their interactions with host cells during infection. Using X-ray crystallography and cryo-electron microscopy, he has determined the structures of numerous viruses, including enterovirus 71, which can cause severe encephalitis in children. He studied the maturation processes of dengue and tick-borne encephalitis viruses and conducts research on bacteriophages, which may serve as an alternative to antibiotics in treating bacterial infections. His work contributes to a deeper understanding of the mechanisms enabling virus infections.“EMBO’s mission is to support research in the life sciences, foster scientific exchange, and shape policies to improve the quality of the research environment in Europe. For me, being elected to EMBO not only acknowledges my past work but also represents a commitment to contributing to the scientific culture and nurturing talent across Europe,” says Pavel Plevka, who also leads the Structural Virology Research Group and serves as Director of CEITEC MUNI.New EMBO members play an active role in the organisation – they help shape research agendas, review grant applications from early-career scientists, and nominate other exceptional individuals to join this prestigious network.The election of Pavel Plevka to EMBO is not only a recognition of his scientific achievements but also a testament to the growing international standing of research conducted in Brno and at Masaryk University, which now has eight EMBO members among the twenty from the Czech Republic.<blockquote>Here you can read the <a target="_blank" rel="noopener noreferrer" href="https://www.embo.org/press-releases/outstanding-life-scientists-elected-to-the-embo-membership/">EMBO press release</a>.</blockquote>

Pavel Plevka from CEITEC Elected Among Europe’s Scientific Elite

Article

Application

Video

Scientists

Health

Science and research

Poster

Since its establishment in 2011, CEITEC has quickly developed into a cutting-edge infrastructure for research which performs highly alongside the best institutes in Europe. Among the main priorities of CEITEC are the promotion of a motivating and dynamic international scientific environment, the provision of state-of-the-art research infrastructure, and the policy of open communication and equal opportunities.

CEITEC

The Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences (IOCB Prague) is a leading scientific institution in the Czech Republic, recognized internationally. Its primary mission is basic research in the fields of chemical biology and medicinal chemistry, organic and material oriented chemistry, chemistry of natural compounds, biochemistry and molecular biology, physical chemistry, theoretical chemistry, and analytical chemistry. 

Ústav organické chemie a biochemie AV ČR

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Business Review Webinars

Reference standards are essential in chromatography to ensure the correct identification of the sample components and the accuracy of quantitation.
In this one-hour presentation, we will explore the definitions and certifications that can impact selection and use of reference standards. Additionally, we’ll review the techniques and documentation required to prepare reproducible and reliable reference standards.
<ul>
<li>Learn what certified reference materials (CRMs) are and why you need them.</li>
<li>Explore the quality controls needed to consistently ensure accurate reference standards.</li>
<li>Understand secondary source standards and how to obtain them.</li>
</ul>

Restek: Building a Rock-Solid Analytical Foundation with Certified Reference Materials (CRMs)

Building a Rock-Solid Analytical Foundation with Certified Reference Materials (CRMs)

Agilent offers a comprehensive inorganic standard portfolio which includes single and multi-elements certified reference materials.
We have enhanced our website to improve the searchability of instrument and application based elemental analysis standards. Agilent now also offers custom standards for your method specific needs.
<blockquote>
Presenter: Fred Chan (Chemical Standards Product Manager - CSD, Agilent Technologies, Inc.)
</blockquote>
<blockquote>
Frederick Chan is a Chemical Standards Product Manager for Agilent’s Consumables and Supplies Division. He has a chemical engineering degree from University of California, Los Angeles and a MBA from University of Denver. Currently resides in Denver, CO and has been with Agilent for 14 years – in both the consumables and services divisions.
</blockquote>
<blockquote>
Presenter: Mitesh Patel (Chemical Standards Product Manager - CSD, Agilent Technologies, Inc.)
</blockquote>
<blockquote>
Mitesh Patel is a Product Manager for Chemical Standards for Consumable and Supplies Division (CSD) at Agilent. Mitesh has 13 years of experience in Chemistry and Material Science field. He has Ph.D. in Chemistry from University of Illinois, Chicago and MBA in Global Management from University of Wisconsin, Milwaukee.
</blockquote>

Agilent Technologies: Agilent Inorganic Standard Portfolio and Website Tools: Part 2 - ICP-OES/MP-AES/AA

Agilent Inorganic Standard Portfolio and Website Tools: Part 2 - ICP-OES/MP-AES/AA

Comprehensive inorganic standard portfolio which includes single and multi-elements certified reference materials.

Agilent Inorganic Standard Portfolio ICP-OES/MP-AES/AA

Agilent Technologies: Agilent Inorganic Standard Portfolio and Website Tools: Part 1 - ICP-MS

Agilent Inorganic Standard Portfolio and Website Tools: Part 1 - ICP-MS

Agilent Inorganic Standard Portfolio and Website - ICP-MS

<h3>Building a strong foundation for your analytical workflow</h3>
Your results are only as accurate as your reference. Within Pharma QC, whether you are performing dissolution testing or releasing finished goods, having accurate, reliable and fully characterized Reference Materials is critical. This webinar will provide viewers with an overview of key concepts relating to Reference Materials.
With a multitude of suppliers serving the industry – both compendial and commercial – there are myriad choices of Reference Materials available for a quality control laboratory. We will discuss how different quality grades are “fit for purpose,” best practices in Reference Material production, and what to look for in a Reference Material Certificate of Analysis.
We will also discuss a novel concept: fully characterized Certified Reference Materials (CRMs) qualified against compendial standards. These CRMs are designed to replace a laboratories in-house working standards and pair with a laboratory’s primary Reference Standards to form a strong, well-characterized and fully traceable Reference Material foundation.
<h3>Key Learning Objectives</h3>
<ul>
<li>Understand how different Reference Material quality grades are fit-to-purpose</li>
<li>Provide key concepts in Reference Material manufacture and characterization</li>
<li>Detail Certificate of Analysis (CoA) key attributes that will be common across sources</li>
</ul>
<h3>Audience</h3>
<ul>
<li>Laboratory Directors</li>
<li>Pharmaceutical Quality Control (QC) Managers</li>
<li>Pharmaceutical Quality Control (QC) technicians</li>
</ul>
<blockquote>
Presenter: Michael Hurst (Product Manager - Reference Materials)
</blockquote>

Pixabay/Mizianitka: Reference Materials in Pharma QC

MilliporeSigma - Reference Materials in Pharma QC

<h4>Eight Webinars and a Roundtable with Experts from Merck&nbsp;</h4>Analytical Excellence Week' is organized to empower professionals in the field of analytical chemistry. Over the course of eight insightful sessions, industry experts will share their knowledge and best practices to streamline your analytical workflows and enhance your efficiency.From understanding quality grades in inorganics and solvents to exploring sustainable practices in the lab, each webinar covers essential topics that will enhance your analytical capabilities. Learn how to optimize your Karl Fischer titration, achieve precision in PFAS testing, and gain troubleshooting tips for LC-MS to effectively address common challenges and improve your laboratory results. The sessions will also address critical aspects of safety and sustainability, ensuring you are well-equipped to handle hazardous chemicals responsibly while making strides toward greener laboratory practices.This is an invaluable opportunity to gain insights that can significantly optimize your analytical processes. Don’t miss your chance to elevate your expertise and contribute to a more efficient and sustainable future in analytical workflows. Each session is specifically designed to address essential topics that directly impact your daily practices, making it relevant for all professionals working in a chemical analysis laboratory.<h3>Day 2: Tuesday, 11 February</h3><h4>Dihydropinene, γ-Valerolactone, and Dimethyl Isosorbide: Bio-Sourced Versatile Green Solvents for Diverse Organic Synthesis</h4>The growing environmental concerns and regulatory restrictions on conventional organic solvents derived from non-renewable sources have spurred the search for greener, sustainable alternatives. This presentation will explore the potential of dihydropinene (DHP), γ-valerolactone (GVL), and dimethyl isosorbide (DMI) as bio-sourced and biodegradable solvents, offering a promising solution to replace toxic and non-renewable solvents. DHP, derived from turpentine oil, is an effective substitute for solvents such as n-hexane, benzene, and dichloromethane, while GVL and DMI are ideal replacements for hazardous solvents such as DMF, NMP, and DMA.These solvents not only perform well in various chemical transformations but also offer significant environmental benefits due to their biodegradability, low toxicity, and recyclability. The presentation will highlight the applications of DHP, GVL, and DMI in green chemistry, showcasing their potential in organic synthesis and industrial processes. It will also discuss their role in advancing sustainable practices, reducing dependency on fossil-based solvents, and promoting safer working environments. By focusing on green solvent solutions, the presentation will emphasize their future potential in scientific research, production, and industrial applications.By attending this webinar, you will learn:<ul><li>Sustainable Solvent Alternatives: How bio-based solvents such as DHP, GVL, and DMI can replace conventional toxic solvents, providing eco-friendly, biodegradable options for chemical processes.</li><li>Environmental and Safety Benefits: The environmental advantages of these solvents, including biodegradability, low toxicity, and recyclability, and how they promote safer and greener practices in research and industry.</li><li>Practical Applications: How these solvents can be effectively used in organic synthesis, industrial processes, and various scientific fields, contributing to more sustainable and efficient chemical solutions.</li></ul>Who should attend: This presentation will benefit those working in pharmaceutical and drug discovery R&amp;D, process development of API, environmental scientists and sustainability experts, industry professionals in chemical engineering and manufacturing, materials science researchers, and students and researchers in green chemistry.<blockquote>Presenter: Saikat Sinha, (R&amp;D Manager, Merck)&nbsp;</blockquote><h4>Enhance Your PFAS Testing: Achieve Precision and Reduce Background Noise with Specialized Consumables</h4>Join this presentation to explore advanced LC-MS/MS methods for determining PFAS analytes at low levels across diverse samples and matrices. Learn how to identify contamination sources, reduce background noise, and improve testing precision with specific recommendations on PFAS-qualified consumables. Discover various LC-MS/MS PFAS testing workflows and strategies to minimize errors, supported by data from both regulated and non-regulated methods.By attending this webinar, you will learn:<ul><li>Detailed insights into different LC-MS/MS PFAS methods</li><li>Techniques to identify and test contamination sources</li><li>Strategies to reduce background noise</li><li>Practical tips and tricks for improved testing</li></ul>Who should attend: This webinar is essential for lab technicians, lab managers, and quality assurance managers involved in developing in-house methods or verifying regulated testing protocols such as EPA Methods 533, 537.1, and 1633.<blockquote>Presenter: Patrik Appelblad, (Fellow and Technical Lead, Analytical Chemistry R&amp;D, Merck)&nbsp;</blockquote>

Merck: Webinar Series & Expert Roundtable

Webinar Series & Expert Roundtable (Day 2)

(Day 2) - Part 1: Dihydropinene, γ-Valerolactone, and Dimethyl Isosorbide: Solvents for Organic Synthesis and Part 2: Enhance Your PFAS Testing

<h4>Eight Webinars and a Roundtable with Experts from Merck</h4>Analytical Excellence Week' is organized to empower professionals in the field of analytical chemistry. Over the course of eight insightful sessions, industry experts will share their knowledge and best practices to streamline your analytical workflows and enhance your efficiency.From understanding quality grades in inorganics and solvents to exploring sustainable practices in the lab, each webinar covers essential topics that will enhance your analytical capabilities. Learn how to optimize your Karl Fischer titration, achieve precision in PFAS testing, and gain troubleshooting tips for LC-MS to effectively address common challenges and improve your laboratory results.The sessions will also address critical aspects of safety and sustainability, ensuring you are well-equipped to handle hazardous chemicals responsibly while making strides toward greener laboratory practices.This is an invaluable opportunity to gain insights that can significantly optimize your analytical processes. Don’t miss your chance to elevate your expertise and contribute to a more efficient and sustainable future in analytical workflows.Each session is specifically designed to address essential topics that directly impact your daily practices, making it relevant for all professionals working in a chemical analysis laboratory.<h3>Day 1: Monday, 10 February</h3><h4>Navigating Quality Grades Part 1: Inorganics and Solvents for Classical Analysis and Research</h4>Join us for an insightful webinar focused on the critical process of selecting the right quality grade for inorganic reagents and solvents used both in analytical and research applications. We will provide an in-depth overview of various quality grades, including ACS grade and EMSURE®, and discuss their specific attributes, including purity, regulatory support, and packaging. Gain valuable insights into the importance of this choice and its impact on the quality of your lab processes and outcomes.By attending this webinar, you will:<ul><li>Understand the significance of choosing the right quality grade for your lab applications</li><li>Explore the available quality grades, including ACS grade and EMSURE®, and their specific attributes</li><li>Recognize the impact of quality grade selection</li><li>Learn best practices for selecting and utilizing the appropriate quality grade for several applications</li></ul>Who should attend:This webinar is designed for professionals involved in laboratory work who seek to enhance their understanding of quality grades for inorganic reagents and solvents. It is particularly relevant for lab technicians, researchers, and managers in analytical labs (like QC, environmental, etc.) method development and research laboratories that are looking to optimize their processes and outcomes.<blockquote>Presenter: Christian Roth (Senior Product Manager Inorganics, Merck)Presenter: Lyra Christianson (Product Manager Solvents, Milwaukee, Wisconsin, USA, an affiliate of Merck)</blockquote><h4>Navigating Quality Grades Part 2: Solvents and Reagents for Chromatography Applications</h4>This second part focuses on the critical process of selecting the right quality grades used in chromatography applications. We provide an in-depth overview of various quality grades, from Suprasolv® solvents for GC to LiChrosolv® solvents for HPLC, in combination with LiChropurTM reagents, and discuss their specific attributes, including purity, regulatory support, and packaging. The topic will be illustrated by typical HPLC and LC-MS applications.By attending this webinar, you will learn:<ul><li>Which grades are suitable for which chromatographic analysis</li><li>What are the specific attributes of the solvents and reagents</li><li>How to combine different quality grades meaningfully</li><li>How to identify and differentiate between various quality grades of reagents and solvents.</li><li>To understand the critical importance of selecting the appropriate quality grade for your specific analytical applications</li></ul>Who should attendLab technicians, lab managers, and quality control-related persons who need to understand how to select the different quality grades for HPLC and LC-MS applications.<blockquote>Presenter: Patric Klein, (Global Product Manager Organic and Inorganics Instrumental Analysis, Merck)Presenter: Fernando Luengo, (Global Product Manager HPLC Solvents, Milwaukee, Wisconsin, USA, an affiliate of Merck)Presenter: Daniel Weibel, (Global Product Manager Solvents, Merck)</blockquote>

Webinar Series & Expert Roundtable (Day 1)

Navigating Quality Grades Part 1: Inorganics and Solvents for Classical Analysis and Research and Part 2: Solvents and Reagents for Chromatography Applications

<h4>Eight Webinars and a Roundtable with Experts from Merck</h4>Analytical Excellence Week' is organized to empower professionals in the field of analytical chemistry. Over the course of eight insightful sessions, industry experts will share their knowledge and best practices to streamline your analytical workflows and enhance your efficiency.From understanding quality grades in inorganics and solvents to exploring sustainable practices in the lab, each webinar covers essential topics that will enhance your analytical capabilities. Learn how to optimize your Karl Fischer titration, achieve precision in PFAS testing, and gain troubleshooting tips for LC-MS to effectively address common challenges and improve your laboratory results.The sessions will also address critical aspects of safety and sustainability, ensuring you are well-equipped to handle hazardous chemicals responsibly while making strides toward greener laboratory practices.This is an invaluable opportunity to gain insights that can significantly optimize your analytical processes. Don’t miss your chance to elevate your expertise and contribute to a more efficient and sustainable future in analytical workflows.Each session is specifically designed to address essential topics that directly impact your daily practices, making it relevant for all professionals working in a chemical analysis laboratory.<h3>Day 3: Wednesday, 12 February</h3><h4>Optimize Your Karl Fischer Titration: Expert Insights for Enhanced Results</h4>With Karl Fischer titration, you can quickly and accurately determine water content in a wide variety of samples. The accuracy of the results depends on a well-defined titration application process. Pre-titration and titer determination are essential for obtaining correct results. The main challenges arise from samples that do not dissolve or that undergo side reactions in standard solvents. Learn the measures you can take to release water from such samples and the preferred methods to use—volumetry or coulometry. Additionally, discover how digital data transfer enables efficient, fast, and secure data integration with your titrator software.By attending this webinar, you will learn:<ul><li>The key steps in the Karl Fischer titration process</li><li>The importance of accurate pre-titration and regular titer determination</li><li>Effective methods for completely releasing water from your samples</li><li>How digital data transfer can streamline and secure your daily data transfer and documentation</li><li>Practical tips for overcoming daily challenges in Karl Fischer Titration</li></ul>Who should attend: This webinar will be especially valuable for individuals involved in developing Karl Fischer titration applications, performing titrations in QC labs or during in-process control, and those responsible for assessing and enhancing processes. This includes lab technicians, lab managers, and quality assurance managers across various segments.<blockquote>Presenter: Bettina Straub-Jubb, (Global Product Manager Analytical Technologies, Merck)</blockquote><h4>Beyond Safety Standards – Best Practices for Safe Handling of Hazardous Chemicals</h4>This webinar illustrates the role of safety in the lab as well as the challenges that can occur while handling hazardous goods in the daily lab work and how to overcome these challenges. Rules and regulations for daily handling of hazardous goods are discussed, and options are shown on how to improve daily processes regarding personal safety. The presentation focuses on the prevention of accidents, emergency help in case of chemical spillages, and safe and reliable cleaning of lab equipment. Join the webinar for an informative overview of safety solutions and tools for maximum safety and reliability in your lab.By attending this webinar, you will learn:<ul><li>Basic safety risks and rules for daily handling of hazardous goods and options for how to improve daily processes regarding personal safety</li><li>Packaging-related safety topics</li><li>Practical guidelines for handling hazardous chemicals in case of spillages</li><li>Lab equipment cleaning know-how for reliable analytical results</li></ul>Who should attend: Staff and head of chemical labs (e.g. quality control, research), as well as safety managers/safety engineers for chemical laboratories.<blockquote>Presenter: Annett Schneider, (Global Product Manager and Lead Expert for Safety Products and Essentials, Merck)&nbsp;</blockquote>

Webinar Series & Expert Roundtable (Day 3)

Part 1: Optimize Your Karl Fischer Titration and Part 2: Beyond Safety Standards – Best Practices for Safe Handling of Hazardous Chemicals

<h4>Eight Webinars and a Roundtable with Experts from Merck</h4>Analytical Excellence Week' is organized to empower professionals in the field of analytical chemistry. Over the course of eight insightful sessions, industry experts will share their knowledge and best practices to streamline your analytical workflows and enhance your efficiency.From understanding quality grades in inorganics and solvents to exploring sustainable practices in the lab, each webinar covers essential topics that will enhance your analytical capabilities. Learn how to optimize your Karl Fischer titration, achieve precision in PFAS testing, and gain troubleshooting tips for LC-MS to effectively address common challenges and improve your laboratory results.The sessions will also address critical aspects of safety and sustainability, ensuring you are well-equipped to handle hazardous chemicals responsibly while making strides toward greener laboratory practices.This is an invaluable opportunity to gain insights that can significantly optimize your analytical processes. Don’t miss your chance to elevate your expertise and contribute to a more efficient and sustainable future in analytical workflows.Each session is specifically designed to address essential topics that directly impact your daily practices, making it relevant for all professionals working in a chemical analysis laboratory.<h3>Day 4: Thursday, 13 February</h3><h4>Greener Solvents - Making Big Moves for More Sustainability in the Lab!</h4>Laboratories consume significantly more energy and water and generate more waste than offices or households. This is more reason for laboratories to tackle sustainability concerns now. This training supports labs to become greener by addressing the class of chemicals that are used in the largest volumes in the lab: solvents! According to the 12 Principles of Green Chemistry, solvents are more sustainable when they are biobased or when they are less dangerous and hazardous.This training highlights several of these greener solvent alternatives and how they can be implemented in the lab. Due to the large volume in which solvents are used, changing to a greener alternative will significantly reduce the carbon footprint of a lab. A further opportunity to reduce the carbon footprint of a lab and to tremendously reduce waste, are returnable containers for solvents, which will be covered in the second part of the training.By attending this webinar, you will learn:<ul><li>The 12 Principles of Green Chemistry</li><li>What greener solvents are and how they can be implemented in your lab</li><li>How returnable containers for solvents reduce the carbon footprint and amount of waste in the lab</li></ul>Who should attend: This webinar will provide valuable insights for everybody who is working with solvents in the lab and would like to become more sustainable. This includes lab technicians, lab managers, and scientists in chemistry and analytical chemistry labs.<blockquote>Presenter: Frank Michel, (Scientific Education &amp; Sustainability, Chemistry Franchise, Merck)Presenter: John Cooper, (Global Product Manager Sustainable Solvents, Milwaukee, Wisconsin, USA, an affiliate of Merck)</blockquote><h4>Tips and Tricks for LC-MS Troubleshooting</h4>LC-MS is an excellent tool for chemical analysis. Moreover, the evolution in HPLC particle technology, HPLC instrument design, and MS detection resulted in improved performance and sensitivity. This raised the bar on requirements for the purity of the solvents and additives in the mobile phase. This training provides valuable tips and tricks on how to get the best performance out of your LC-MS instrument regarding sensitivity and how to limit instrument downtime by different approaches. Typical examples of LC-MS issues, such as ghost peaks or noisy and elevated baselines, and how to prevent them will be presented. Advanced LC-MS solvents and additives for improved LC-MS performance and their proper handling will be discussed in detail.By attending this webinar, you will learn:<ul><li>The importance of the choice of consumables and solvents for LC-MS</li><li>Approaches to improve sensitivity and robustness of LC-MS</li></ul>Who should attend: This webinar will be especially valuable for scientists, lab managers, and lab technicians working with LC-MS in any application area.<blockquote>Presenter: Frank Michel, (Scientific Education &amp; Sustainability, Chemistry Franchise, Merck)</blockquote>

Webinar Series & Expert Roundtable (Day 4)

Part 1: Greener Solvents - Making Big Moves for More Sustainability in the Lab! and Part 2: Tips and Tricks for LC-MS Troubleshooting.

<h4>Eight Webinars and a Roundtable with Experts from Merck</h4>Analytical Excellence Week' is organized to empower professionals in the field of analytical chemistry. Over the course of eight insightful sessions, industry experts will share their knowledge and best practices to streamline your analytical workflows and enhance your efficiency.From understanding quality grades in inorganics and solvents to exploring sustainable practices in the lab, each webinar covers essential topics that will enhance your analytical capabilities. Learn how to optimize your Karl Fischer titration, achieve precision in PFAS testing, and gain troubleshooting tips for LC-MS to effectively address common challenges and improve your laboratory results.The sessions will also address critical aspects of safety and sustainability, ensuring you are well-equipped to handle hazardous chemicals responsibly while making strides toward greener laboratory practices.This is an invaluable opportunity to gain insights that can significantly optimize your analytical processes. Don’t miss your chance to elevate your expertise and contribute to a more efficient and sustainable future in analytical workflows.Each session is specifically designed to address essential topics that directly impact your daily practices, making it relevant for all professionals working in a chemical analysis laboratory.<h3>Day 5: Friday, 14 February</h3><h4>Roundtable Expert Discussion</h4>Our experts will come together to discuss the best practices to streamline your analytical workflows and enhance your efficiency. We will cover some questions asked during the week, as well as answer new questions during the roundtable discussion. &nbsp;<blockquote>Presenter: Ernie Hillier (Independent Pharmaceutical Consultant, EJH Consulting)</blockquote>

ICPMS webinars focusing on Chemicals & Standards | LabRulez ICPMS

Webinar Series & Expert Roundtable (Day 5)