The international standard ISO/IEC 17025 [1] clause 7.7.2 with regards to ensuring the validity of results, requires a laboratory to participate in proficiency testing (PT) and/or to participate in interlaboratory comparisons (ILCs) other than PT. However, no guidance as to what these other ILCs might be, or indeed how they might compare in relation to PT, is provided. This leaflet aims to outline other ILCs available, pointing out some of the limitations as compared to PT.&nbsp;There are three major types of ILCs in which a group of laboratories analyses identical portions from a homogeneous, stable test sample, with each type being characterized by its intended purpose [2,3]:<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Eurachem_Interlaboratory_comparisons_other_than_proficiency_testing_2_d9263807fb.jpg" alt="Eurachem: Interlaboratory comparisons other than proficiency testing" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Eurachem_Interlaboratory_comparisons_other_than_proficiency_testing_2_d9263807fb.jpg 245w," sizes="100vw" width="1507" height="607">A key point is that PT is an ILC that is designed to specifically evaluate the performance of participants, providing them with an infrastructure to monitor and assess the validity of their results. This is not the key purpose of the two other ILCs, and thus depending on their intended purpose they have a number of limitations that laboratories need to be aware of when using them rather than PT. Only proficiency testing should have been conducted in full compliance to the competency standard ISO/IEC 17043 [4].&nbsp;<h4>Evaluation of measurement procedure performance&nbsp;</h4>These ILCs, are designed to assess how a particular measurement procedure performs and whether it is fit for its intended purpose. These ILCs are often referred to as a ‘method performance study’ or a ‘collaborative study’ [2]. Some limitations of using such ILCs for monitoring laboratory performance as an alternative to PT are:&nbsp;<ul><li>All participants use the same measurement procedure i.e. the measurement procedure that is being validated. Unless the measurement procedure is being routinely used by the participating laboratory such an ILC will not assess the routine performance of the laboratory using their own routine measurement procedure. Nor does it enable them to compare their performance with other laboratories using alternative measurement procedures.&nbsp;</li><li>The measurement procedure is likely to be new, so participants may not have established stable procedures and quality control, so performance may not reflect routine use.&nbsp;</li><li>The report from such an ILC would not provide information on the performance of the participant, if the statistical model used makes the assumption that all laboratories perform with equal variability.</li><li>The design of the study may require the participants to assess multiple samples and/or to undertake multiple replicate analysis on the test materials. This may not be representative of the routine measurements or tests undertaken by the laboratory.&nbsp;</li><li>The conclusion of the ILC might be that the measurement procedure being assessed is not valid.&nbsp;</li></ul><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Eurachem_Interlaboratory_comparisons_other_than_proficiency_testing_3_a53ecd2f5d.jpg" alt="Eurachem: Interlaboratory comparisons other than proficiency testing" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Eurachem_Interlaboratory_comparisons_other_than_proficiency_testing_3_a53ecd2f5d.jpg 157w," sizes="100vw" width="570" height="566"><h4>Characterisation of candidate reference materials&nbsp;</h4>These are ILCs that assign a property value to a candidate reference material, usually with a stated measurement uncertainty. These are often referred to as a ‘material certification study’ [2]. Limitations of using such ILCs as an alternative to PT are:&nbsp;<ul><li>The analysis of the candidate reference material is likely to require additional care in exercising the routine measurement procedure, such as substantially more replication, and/or may require quite different reporting formats (e.g. all valid replicates instead of a mean result). Thus, such an ILC will not necessarily provide an evaluation of the performance of the laboratory based on the routine use of their measurement procedures.&nbsp;</li><li>The report from such an ILC may include the results from the participating laboratories but would not provide information on the performance of each laboratory.&nbsp;</li><li>Participating laboratories may be required to assess multiple samples and/or to undertake multiple replicate analysis on the candidate reference materials. Thus this may not be representative of the routine measurements or tests undertaken by the laboratory.&nbsp;</li></ul><h4>Other ILCs&nbsp;</h4>Some other ILCs, whilst not being conducted in full compliance of the requirements of ISO/IEC 17043, may be designed to evaluate participant performance. These would include small ILCs as defined by EA‑2/21 [5] or split sample ILCs i.e. where a portion of a single sample is sent to two or three laboratories. Whilst these ILCs are specifically designed to evaluate participant performance, they may not provide a comprehensive comparison that a PT might provide. In such cases the laboratory needs to evaluate carefully the competence of the organization managing the ILC and the suitability of the service externally provided (ISO/IEC 17025 clause 6.6).

Interlaboratory comparisons other than proficiency testing

Our Library never stops expanding. What are the most recent contributions to LabRulezICPMS Library in the week of 29th June 2026? Check out new documents from the field of spectroscopy/spectrometry and related techniques!<blockquote>👉 <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/library">SEARCH THE LARGEST REPOSITORY OF DOCUMENTS ABOUT SPECTROSCOPY/SPECTROMETRY RELATED TECHNIQUES</a></blockquote><blockquote>👉 Need info about different analytical techniques? Peek into <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/library">LabRulezLCMS</a> or <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library">LabRulezGCMS</a> libraries.</blockquote>This week we bring you application notes by Agilent Technologies and Thermo Fisher Scientific and brochure by Shimadzu!<h3>1. Agilent Technologies: Analysis of High Purity Titanium Using an <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/library?mainauthorItems=10&amp;search=9500">Agilent 9500 ICP-QQQ</a></h3>Ensuring purity and performance of titanium materials used in high-tech industries&nbsp;<ul><li>Application note</li><li><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/labrulez-bucket-strapi-h3hsga3/an_high_purity_titanium_9500_icp_qqq_5994_9024en_agilent_56ab5e943b.pdf">Full PDF for download</a></li></ul><h5>Importance of high-purity titanium and the role of ICP-QQQ&nbsp;</h5>High-purity titanium (Ti) is a critical material in high-tech industries such as semiconductor manufacturing and aerospace engineering. In semiconductor applications, Ti is widely used as a sputtering target for thin-film deposition, where even trace levels of impurities can negatively affect film uniformity, electrical properties, and device reliability. In aerospace applications, Ti is valued for its high strength-to-weight ratio and corrosion resistance, making it an ideal material for engine components and structural parts. However, any impurities can compromise the mechanical integrity and diminish the long-term performance of components, especially when operating under extreme conditions.Ensuring the reliability and functionality of Ti in these demanding environments requires precise quantification of trace impurities in the raw material. Triple quadrupole Inductively Coupled Plasma Mass Spectrometry (ICP-QQQ) provides robust suppression of spectral interferences and ultra-low detection limits (DLs), enabling accurate determination of impurities at or below the 1 mg/kg (ppm) level in the solid. This level of sensitivity is particularly important for quality control (QC) of high-purity Ti, where conventional techniques such as XRF, ICP-OES, and GD-MS lack the sensitivity and DLs.&nbsp;For unrivalled interference reduction using reactive cell gases, Agilent ICP-QQQ instruments include two unit mass (1 u) quadrupole mass filters, Q1 and Q2.1 Q1 is positioned before the collision/reaction cell (CRC) to select which ions enter the cell for reaction with the cell gas. Q2 filters ions that exit the cell before they pass to the detector. This tandem mass spectrometer (MS/MS) operation allows for unmatched control of reaction chemistry in the CRC, making the technique useful for handling intense spectral interferences, including polyatomic, doubly charged ion (M++), isobaric, and peak overlap interferences.&nbsp;Using the newly developed <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/library?mainauthorItems=10&amp;search=9500">Agilent 9500 Triple Quadrupole ICP-MS</a> featuring a Dual-Cell System (DCS) CRC and equipped with an optional m-lens, analysts can confidently analyze Ti matrix samples and verify material purity over extended measurement periods. The m-lens is designed with an optimized geometry that minimizes background signals from easily ionized elements that can deposit on interface components during long runs. This feature enables the instrument to maintain high-power, matrix-tolerant plasma conditions while achieving ultralow background equivalent concentrations (BECs), which is critical for ppt-level impurity analysis. Operating the DCS with a suitable cell gas effectively controls spectral interferences from Ti-based species (Ti²+ and TiO+ ) that impact elements like sodium (Na), magnesium (Mg), copper (Cu), and zinc (Zn). Together with the m‑lens, this approach ensures accurate measurement of trace elemental impurities, enabling compliance within stringent industry standards. The effectiveness of the m‑lens in minimizing background signals and enabling ppt‑level impurity analysis under robust plasma conditions has also been demonstrated in high-matrix applications using ICP‑QQQ.2, 3 In addition to interference control, the 9500 ICP-QQQ system’s robustness and reproducibility make it well suited for routine analysis in both research and production settings. This capability supports the continued advancement of high-tech applications that rely on ultra-clean titanium.In this study, a 200 ppm Ti solution prepared from a high-purity Ti powder was used to represent a typical sample encountered in advanced material analysis. The performance of the 9500 ICP-QQQ for quantifying trace impurities, including Na, Mg, Cu, and Zn, in a high Ti matrix was assessed through spike-recovery experiments and long-term stability tests.<h4>Conclusion&nbsp;</h4>This study demonstrated the effectiveness of the Agilent 9500 ICP-QQQ with m-lens for the ultra-trace analysis of impurity metals in high-purity titanium. By applying optimized reaction gas conditions and mass-shift techniques, spectral interferences from Ti-based species such as Ti²+ and TiO+ were successfully mitigated, enabling accurate quantification of elements like Mg, Cu, and Zn.&nbsp;The method achieved limits of quantification in the sub-ppm range for the undiluted Ti digestion solution and maintained stable ISTD signals over extended measurement periods. Spike recovery tests confirmed high accuracy and reproducibility, with most elements showing recoveries within ±10% and RSDs below 3%.&nbsp;These results confirm that the 9500 ICP-QQQ is a robust and reliable tool for quality control of high-purity Ti, supporting its critical applications in semiconductor and aerospace industries where impurity levels must be strictly controlled.<h3>2. Shimadzu: Scanning Probe Microscope /Atomic Force Microscope SPM-9700HT Plus</h3><ul><li>Brochure</li><li><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/labrulez-bucket-strapi-h3hsga3/c147_e021_4c550d3be3.pdf">Full PDF for download</a></li></ul>The Shimadzu SPM-9700HT Plus is a high-throughput scanning probe microscope (SPM) / atomic force microscope (AFM) designed for three-dimensional surface imaging and nanoscale characterization of material properties across a broad range of scientific and industrial applications. The system combines high-resolution topographical imaging with multiple AFM measurement modes, including contact, dynamic, phase, lateral force, force modulation, and force-curve measurements, while optional modules extend its capabilities to techniques such as Kelvin probe force microscopy (KPFM), magnetic force microscopy (MFM), conductive AFM, piezoresponse force microscopy (PFM), and scanning tunneling microscopy (STM). A wide selection of interchangeable scanners, environmental accessories, optical microscope units, and specialized sample holders enables the instrument to be configured for diverse analytical requirements.A major focus of the brochure is the system's emphasis on automation and ease of use through Shimadzu's Analytical Intelligence technology. Features such as Observation Navigation, NanoAssist, and the optional Cantilever Master automate instrument setup, cantilever installation, optimization of imaging parameters, and measurement workflows, allowing operators with varying levels of experience to acquire high-quality, reproducible AFM data. The redesigned control electronics and scanning system also enable high-throughput imaging and rapid physical property mapping while maintaining nanoscale resolution. In addition, the head-slide mechanism simplifies sample exchange without removing the cantilever, increasing productivity during routine measurements.Beyond surface topography, the SPM-9700HT Plus provides extensive quantitative analysis capabilities through integrated software for roughness measurements, particle analysis, cross-sectional profiling, and morphological characterization. Optional Nano 3D Mapping Fast technology extends the instrument to nanoscale mechanical property measurements by performing force-curve mapping, allowing localized evaluation of adhesion, Young's modulus, and other mechanical properties of thin films, polymers, biomaterials, and soft samples. The optional Particle Analysis Software further enables automated extraction, classification, statistical evaluation, and export of particle size and morphology data for large datasets.The brochure demonstrates the versatility of the platform through numerous application examples spanning electronics, semiconductor devices, magnetic materials, life sciences, industrial materials, batteries, polymers, nanomaterials, food science, and chemistry. Representative studies include magnetic domain imaging, organic thin-film transistor characterization, collagen and DNA visualization, live-cell imaging, lithium-ion battery electrode and separator analysis, photocatalyst surface potential measurements, polymer phase imaging, cellulose nanofiber characterization, and beer yeast morphology. Together, these examples highlight the Shimadzu SPM-9700HT Plus as a comprehensive AFM platform capable of combining rapid imaging, advanced nanoscale property mapping, and automated data analysis for both research and routine industrial quality control.<h3>3. Thermo Fisher Scientific: Enhancing Monoclonal Antibody Yield and Quality Through Automated Multi-Component Feedback Control Loops Using the MarqMetrix All-In-One Process Raman Analyzer</h3><ul><li>Application note</li><li><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/labrulez-bucket-strapi-h3hsga3/enhancing_monoclonal_antibody_an1506_en_bba763e865.pdf">Full PDF for download</a></li></ul>The application of Raman spectroscopy for real-time monitoring and control of bioreactors marks a significant advancement in bioprocessing technology. Over the past decade, its adoption has enabled tighter control of critical process parameters (CPPs), offering early indicators of process performance to ensure consistency and improve product quality. Raman spectroscopy leverages the unique vibrational signatures of molecules, allowing for highly specific detection even in complex biological matrices. This enables simultaneous, real-time monitoring of multiple CPPs, including nutrient concentrations, metabolic by-products, and cell density. As a result, users gain deep, real-time insights into cellular metabolism and can implement more dynamic, adaptive feeding strategies based on metabolic network understanding.&nbsp;Previous studies have demonstrated the negative impact of high lactate on cell health and quantity and quality of titer produced.² In this study, we demonstrate the successful implementation of process Raman analyzer for simultaneous multi-component feedback control of glucose and lactate in a bioreactor. By continuously monitoring both analytes, the feedback control loop dynamically maintained a constant total carbon concentration (glucose + lactate) at a setpoint of 2 g/L.&nbsp;This advanced carbon-source-based control strategy ensured that cellular metabolic demands were met while promoting lactate consumption toward the end of the run. As a result, lactate accumulation was significantly reduced, leading to substantial improvements in titer yield, product quality, and cell viability compared to standard bolus feeding strategies (Figure 2).The outcomes of this work underscore the <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/products/2233">Thermo Scientific™ MarqMetrix™ All-In-One Process Raman Analyzer </a>as a key Process Analytical Technology (PAT) tool-enabling real-time, multi-analyte control for any biomanufacturer seeking to engage in intelligent, automated biomanufacturing.<h4>Conclusion&nbsp;</h4><h5>1. Unmatched Real-Time Control Capability:&nbsp;</h5>Maintaining a constant total carbon concentration (glucose + lactate) of 2 g/L in dynamic bioreactor environments demands precise, simultaneous analyte monitoring. The MarqMetrix All-In-One Process Raman Analyzer delivers near real-time, high-fidelity data every two minutes, empowering advanced control strategies that are simply not feasible with conventional technologies. This makes it an indispensable PAT tool for modern bioprocessing.&nbsp;<h5>2. Proven Impact on Product Yield and Quality:&nbsp;</h5>The Raman-enabled carbon control strategy resulted in a &gt;10% increase in titer and a reduction in glycation by 83% and 66% compared to continuous and fed-batch glucose control, respectively. These outcomes underscore the analyzer’s transformative impact on both product quantity and quality.&nbsp;<h5>3. Versatile Automation Across Bioprocesses:&nbsp;</h5>All three bioreactor runs—each employing distinct control logics (Table 2)—were successfully managed through automated feedback using the process Raman analyzer. Its flexible design, including easily swappable probes, supports seamless adaptation to other critical metabolites such as amino acids, making it a universal solution for bioprocess control.&nbsp;<h5>4. Foundation for Intelligent Manufacturing:&nbsp;</h5>With its real-time, data-rich insights and seamless integration into automated systems, the MarqMetrix All-InOne analyzer is not just a monitoring tool; it is a cornerstone technology for intelligent, AI-driven biomanufacturing. It enables consistent, high-quality production while reducing time, cost, and variability.

News from LabRulezICPMS Library - Week 27, 2026

Scientists from CEITEC Brno University of Technology led by Markéta Kaiser have achieved a globally unique breakthrough in coral research. Using the live microCT method, they were able, for the first time ever, to observe the growth of living marine corals in real time and reveal the processes behind the formation of their calcium carbonate skeletons, which had previously remained hidden beneath the surface. The results of the international study, published in the prestigious journal Science Advances, show how corals grow, regenerate, and respond to stress and competing organisms.The <a target="_blank" rel="noopener noreferrer" href="https://www.science.org/doi/10.1126/sciadv.aee3183">study</a> was carried out through a collaboration between researchers from Brno, Vienna, and several other international institutions. A key role was played by the X-ray Micro and Nano Computed Tomography Laboratory (CTLAB) at CEITEC BUT, where all the crucial data and three-dimensional coral models were produced. CEITEC also shares both the first and corresponding authorship of the study.“Thanks to live microCT, we were able, for the first time, to observe what happens beneath the surface of a coral skeleton,” explains Markéta Kaiser from CTLAB at CEITEC BUT. “For example, we witnessed situations where a coral, after being attacked by algae, completely halted its normal growth and began building a protective wall around the threatened area. Once the danger had passed, it was able to resume its original growth pattern.”<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/CEITEC_Zivi_korali_jezdili_vlakem_z_Vidne_do_Brna_Vedci_diky_nim_odhalili_jejich_tajny_zivot_540e183e84.jpeg" alt="CEITEC BUT/Jakub Rozboud: Live Corals Traveled by Train from Vienna to Brno. Scientists Uncovered Their Secret Life: Markéta Kaiser, CTLAB CEITEC at CEITEC BUT." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_CEITEC_Zivi_korali_jezdili_vlakem_z_Vidne_do_Brna_Vedci_diky_nim_odhalili_jejich_tajny_zivot_540e183e84.jpeg 235w," sizes="100vw" width="1600" height="1067">The scientists successfully captured coral growth both vertically and horizontally, the formation of protective barriers against competing organisms, and regeneration mechanisms following damage.The research was exceptionally demanding from a technological standpoint. The team had to develop a special system that enabled living corals to be safely scanned directly in seawater. The coral colonies regularly traveled by train from Vienna to Brno for measurements and, after several hours, were transported back to professional aquarium systems in Vienna.“At first, it seemed like a somewhat crazy idea. No one knew whether living corals could withstand repeated scanning,” says Kaiser. “Gradually, however, we found that they survived, continued to grow, and provided us with unique data.”<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/CEITEC_Zivi_korali_jezdili_vlakem_z_Vidne_do_Brna_Vedci_diky_nim_odhalili_jejich_tajny_zivot_2_fcbb29a4f6.jpeg" alt="CEITEC BUT/Jakub Rozboud: Live Corals Traveled by Train from Vienna to Brno. Scientists Uncovered Their Secret Life: Markéta Kaiser is placing a coral sample into CT for scanning." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_CEITEC_Zivi_korali_jezdili_vlakem_z_Vidne_do_Brna_Vedci_diky_nim_odhalili_jejich_tajny_zivot_2_fcbb29a4f6.jpeg 235w," sizes="100vw" width="1600" height="1067">The original concept for the project came from developmental biologist Igor Adameyko of the Medical University of Vienna, who proposed combining marine biology with advanced imaging technologies more commonly used in engineering and technical fields.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/CEITEC_Zivi_korali_jezdili_vlakem_z_Vidne_do_Brna_Vedci_diky_nim_odhalili_jejich_tajny_zivot_3_8c5f376f41.jpeg" alt="CEITEC BUT/Markéta Kaiser: Live Corals Traveled by Train from Vienna to Brno. Scientists Uncovered Their Secret Life: Corals CT - 1." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_CEITEC_Zivi_korali_jezdili_vlakem_z_Vidne_do_Brna_Vedci_diky_nim_odhalili_jejich_tajny_zivot_3_8c5f376f41.jpeg 228w," sizes="100vw" width="1600" height="1096">The findings of the Brno researchers have already attracted the attention of experts in Okinawa, Japan, who specialize in coral reef research. They plan to use the live microCT method to study the effects of light, photosynthesis, and environmental changes on coral growth.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/CEITEC_Zivi_korali_jezdili_vlakem_z_Vidne_do_Brna_Vedci_diky_nim_odhalili_jejich_tajny_zivot_4_445c1cc3b7.jpeg" alt="CEITEC BUT/Markéta Kaiser: Live Corals Traveled by Train from Vienna to Brno. Scientists Uncovered Their Secret Life:Corals CT - 2." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_CEITEC_Zivi_korali_jezdili_vlakem_z_Vidne_do_Brna_Vedci_diky_nim_odhalili_jejich_tajny_zivot_4_445c1cc3b7.jpeg 245w," sizes="100vw" width="1600" height="988">According to the researchers, the project demonstrates the importance of interdisciplinary collaboration between engineering and biological sciences. The research could contribute not only to the study and conservation of coral reefs, but also to fields such as paleontology and materials science.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/CEITEC_Zivi_korali_jezdili_vlakem_z_Vidne_do_Brna_Vedci_diky_nim_odhalili_jejich_tajny_zivot_5_514ee9c974.jpg" alt="CEITEC BUT/Markéta Kaiser: Live Corals Traveled by Train from Vienna to Brno. Scientists Uncovered Their Secret Life: Corals CT - 3." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_CEITEC_Zivi_korali_jezdili_vlakem_z_Vidne_do_Brna_Vedci_diky_nim_odhalili_jejich_tajny_zivot_5_514ee9c974.jpg 143w," sizes="100vw" width="1600" height="1750"><blockquote><h4>Original Article</h4><h4><a target="_blank" rel="noopener noreferrer" href="https://www.science.org/doi/10.1126/sciadv.aee3183">Coral growth, retraction, defense, and regenerative strategies revealed by live microCT</a></h4>Karina Araslanova, Marketa Kaiser, Anton Fetisov, Diana Gavrik, Tomas Zikmund, Daniel Abed-Navandi, Karel Katovský, Jozef Kaiser, Igor AdameykoSci. Adv., 2026, 12, eaee3183<a target="_blank" rel="noopener noreferrer" href="https://doi.org/10.1126/sciadv.aee3183">https://doi.org/10.1126/sciadv.aee3183</a><h6>licenced under <a target="_blank" rel="noopener noreferrer" href="https://creativecommons.org/licenses/by/4.0/">CC-BY 4.0</a></h6></blockquote><h4>Abstract</h4>Understanding how corals build and remodel their skeletons is key to explaining reef resilience, yet most insights come from static imaging. Using longitudinal live microCT, we tracked the same coral colonies over weeks to months at micrometer resolution. Coral skeleton formation is not a uniform accretion process but a dynamic integration of multiple programs, including vertical and horizontal patterned growth, previously undescribed defensive wall-building against competitors, exploratory edge behavior with reversible expansions and retractions, and skeletal regeneration favoring rapid, imprecise yet effective matrix expansion. Time-resolved imaging links colony-scale growth to microscale events, showing that all modes depend on balances between fusion of skeletal microparticles and layered matrix deposition, guided by tissue prepatterning. Beyond corals, this framework generalizes to studying skeletal dynamics across diverse biomineralizing organisms.

Live Corals Traveled by Train from Vienna to Brno. Scientists Uncovered Their Secret Life 

Article

Application

Academy

Science and research

Since its establishment in 2011, CEITEC has quickly developed into a cutting-edge infrastructure for research which performs highly alongside the best institutes in Europe. Among the main priorities of CEITEC are the promotion of a motivating and dynamic international scientific environment, the provision of state-of-the-art research infrastructure, and the policy of open communication and equal opportunities.

CEITEC

Eurachem is a European network promoting international traceability of chemical measurements and good analytical practice. It provides expert guidance, supports method validation, uncertainty evaluation, proficiency testing, and facilitates discussion on technical and policy issues in analytical quality.

Eurachem

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New Food magazine

Agilent Technologies

Unchained Labs

Thermo Fisher Scientific

C&EN

This series will go through the Fundamentals of Atomic Spectrometry, with a focus on Inductively Coupled Plasma Mass Spectrometry (ICP-MS).
<blockquote>
Presenter: Yan Cheung, PhD (Application Scientist, Agilent Technologies, Inc.) Yan received her Ph.D. in Analytical Chemistry from Indiana University Bloomington. She joined Agilent Technologies as an Application Scientist in the Life Science and Chemical Analysis team in April 2020. Yan has extensive experience in operating and method development in ICP-MS. Yan also has years of experience working in the oil and gas industry.
</blockquote>

Agilent Technologies: Fundamentals of Mass Spectrometry: ICP-MS

Fundamentals of Mass Spectrometry: ICP-MS

Inductively Coupled Plasma Mass Spectrometry (ICP-MS).

Agglomeration of ingredients in tablets is a concern for formulators.
It is typically observed using Raman spectroscopy, an extremely time-consuming technique. This presentation will discuss an alternative to Raman, i.e., &quot;Laser Direct Infrared Imaging&quot;, which provides rapid imaging of content distribution in tablets.
<blockquote>
Presenter: Louis Tisinger (Application Engineer, Molecular Spectroscopy, Agilent Technologies, Inc.)
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<blockquote>
Louis (Lou) Tisinger has a Ph.D. in Analytical Chemistry from Miami University in Oxford Ohio, where his graduate research involved the study of ATR imaging and microscope performance in vibrational spectroscopy. Most of his career has been related to pre- and post-sales support of FTIR spectrometers, microscopes, imaging systems, and thermal analytical instruments, focusing on analyzing customer samples, demonstrations, post-sales training, troubleshooting, and R&amp;D.
</blockquote>

Agilent Technologies: Convenient Way to Evaluate Content Distribution in Solid Dosage Forms

Convenient Way to Evaluate Content Distribution in Solid Dosage Forms

An alternative to Raman, i.e., "Laser Direct Infrared Imaging", which provides rapid imaging of content distribution in tablets.

Evaluate Content Distribution in Solid Dosage Forms

Mineral samples present several challenges when analyzing for trace elements by ICP-OES, these include complex matrices and potential interferences, that may ultimate affect the sensitivity of the system.
This webinar will show you how to overcome these challenges by developing simple and robust methods for more reliable and reproducible results.
<blockquote>
Presenter: Ana García González (Atomic Spectroscopy Application Scientist, Agilent Technologies)
</blockquote>
<blockquote>
Ana Garcia is the Atomic Spectroscopy Application Scientist at Agilent Technologies. Ana has a broad background in atomic spectroscopy technologies, including international experience developing and validating analytical spectroscopy methods for the geochemical industry. She has also published in the fields of molecular spectroscopy and chemometrics. Ana holds a MSc in plant Biotechnology at CINVESTAV, México, and a Bachelor of Science in Biotechnology Engineering.
</blockquote>

Agilent Technologies: Geochemical Analysis at the Speed of Light with ICP-OES

Geochemical Analysis at the Speed of Light with ICP-OES

How to overcome these challenges by developing simple and robust methods for more reliable and reproducible results.

Techniques and tools for improve wash out of “sticky” elements, such as B, Tl, and Hg, on an Agilent ICP-MS will be discussed. An understanding where the individual elements stick in the instrument aids in the chemistry and the sequence of rinse solutions used for their removal.
Use of the Pre-emptive rinse and Intelligent Rinse features within the MassHunter software greatly improve washout of these sticky elements. Features and setup of an Integrated Sample Introduction System (ISIS) also reduce carry over of these elements. Eliminating contamination increases the probability that accurate sample results can be obtained. Sources of common lab contaminants and methods used for their elimination will also be discussed. A semi-Cool plasma technique may be discussed to demonstrate how to calibrate and obtain somewhat lower levels of alkali metals in the presence of their interferences.
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Presenter: Jason Wintrode (Application Scientist, Agilent Technologies, Inc.)
</blockquote>
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Jason has been with Agilent since 2016 and worked as a Field Service Engineer until taking the role of an ICP-MS applications scientist in the fall of 2018. He has focused on ICP-MS for environmental, applications. Previous to Agilent He worked in an environmental lab performing analysis using ICPMS, ICP-OES, and Hg instrumentation for 15 years. Jason obtained a master’s of science degree in chemistry from Montana State University in Bozeman, MT.
</blockquote>

Agilent Technologies: Minimize Carry Over and Contamination on Your Agilent ICP-MS

Minimize Carry Over and Contamination on Your Agilent ICP-MS

Techniques and tools for improve wash out of “sticky” elements, such as B, Tl, and Hg, on an Agilent ICP-MS will be discussed.

Have you fully exploited the potential of your analytical techniques in edible oil analysis? Our experts will reveal what you can achieve with CNSX-analysis, ICP-OES, AAS and UV/Vis in regulated standard analysis and beyond.
Price fluctuations, supply bottlenecks and export stops have highlighted in recent years how volatile and complex the supply chains of edible oils are. Exporters, importers and processors of edible oils face the challenges of rapid supplier qualification while achieving regulatory compliant, seamless, and efficient quality monitoring of their crude oil, intermediates and final products.
As agricultural products, edible oils are subject to natural quality fluctuations, while cultivation methods and long transport routes pose risks of contamination and oxidation. In addition, they go through a temperature- and additive-intensive process with the refinery, during which undesirable by-products can arise under certain circumstances.
Our webinar is aimed at industry, regulatory and contract laboratories involved in the analysis of edible oils. With combustion elemental analysis, ICP-OES, AAS and UV/Vis molecular spectroscopy, our experts will introduce four techniques which enable precise, efficient, and standard-compliant quality and process analysis of edible oils. They will also show you tips and tricks on how to exploit the additional potential for optimising your analytical workflows regarding the targeted and economic use of elaborate specific techniques.
Learn how to use these techniques for a variety of oils at different steps in the value and processing chain, and how to achieve optimal results and increase sample throughput.
Key learning points:
<ul>
<li>Explore how to carry out the comprehensive analysis of toxic elements, process inhibitors, catalyst poisons as well as the macro-mineral content with ICP-OES.
</li>
<li>Learn what combustion analysis can achieve in quality control and process monitoring, especially regarding the formation of unwanted compounds during refining.
</li>
<li>Discover how to streamline analytical workflows with quick screens for organic and inorganic Sulfur and Nitrogen as sum parameters with combustion analysis.
</li>
<li>Find out how to assess oxidation in oils via DOBI index, and how to monitor the efficiency of bleaching in refinery using UV/Vis spectrometry.
</li>
<li>Discover what AAS can do as an alternative spectrometric element technique in the analysis of edible oils.
</li>
<li>Meet our experts and discuss with us in the Q&amp;A.
</li>
</ul>
<blockquote>
Presenter: Dr. Angela Gröbel (Senior Product Manager / Expert Supervisor Chemical Analysis)
</blockquote>
<blockquote>
Angela is a Senior Product Manager and Expert Supervisor for the combustion elemental analysis and related sample preparation portfolio. She holds a PhD in analytical chemistry. Angela developed Analytik Jena’s first trace elemental analysis product line for organic matter, later she became an expert in determination of Sulfur, Nitrogen, and Chlorine across a broad range of industry segments, including oil and gas, food and agriculture and environmental protection. Since 2013 Angela has been Product Manager, responsible for the entire combustion elemental analysis and related sample preparation portfolio.
</blockquote>
<blockquote>
Presenter: Dr. Holger Sievers (Application Specialist Chemical Analysis)
</blockquote>
<blockquote>
Holger Sievers is an Application Specialist at Analytik Jena. He holds a PhD from the Technical University of Munich in the field of ultra-trace analysis of noble metals which he obtained after his Master’s focusing on inorganic and analytical chemistry. Holger joined Analytik Jena in 2018 after seven years of teaching at the University and is currently engaged in chemical analysis. His primary focus lies in atomic absorption spectrometry and element analysis in general.
</blockquote>
<blockquote>
Presenter: Sandra Wunsch (Application Specialist Chemical Analysis)
</blockquote>
<blockquote>
Sandra Wunsch has been an Application Specialist for molecular spectrometry at Analytik Jena since 2016. She has intense in-depth knowledge in scientific and industrial application of molecular spectrometry, and extensive experience in the market and application fields, especially in the areas of environment and food &amp; agriculture. As a graduated Nutritionist, she is an expert in the use of chemical analysis and especially the determination of molecular compounds in the food industry and related fields.
</blockquote>

New Food: Edible oil processing: How to monitor elements and compounds

Edible oil processing: How to monitor elements and compounds

How to use these techniques for a variety of oils at different steps in the value and processing chain, and how to achieve optimal results.

Effective oil and condition monitoring enables proactive maintenance strategies and minimizes unexpected failures of machinery such as turbines.
By closely monitoring the condition of lubricating oils, maintenance professionals can reduce downtime, extend equipment lifespan and identify potential issues before they escalate. Antioxidants are often added to mitigate these issues, which makes monitoring these chemicals critical for equipment performance. 
Join Paul Swan, Technical Manager, APAC at ALS Tribology, and Larry Tucker, Director of Norms and Standards at Metrohm USA, as they discuss vital aspects of oil and condition monitoring and the importance of antioxidants in tribology. Gain valuable knowledge on ASTM methods and discover the latest insights into improvements being made in these areas. 
Key Learning Objectives:
<ul>
<li>Importance of antioxidants in lubricants and their impact on equipment performance
</li>
<li>How to use voltammetry as a tool to monitor remaining useful life on antioxidants in lubricating oils
</li>
<li>Importance of oil analysis in predictive maintenance strategies
</li>
<li>Understanding the significance of condition monitoring in preventing unexpected failures
</li>
<li>Insights into developments aimed at refining ASTM methods
</li>
</ul>
Who Should Attend:
<ul>
<li>Anyone currently monitoring remaining useful life of antioxidants in lubricating oils
</li>
<li>Anyone using ASTM methods for oil and condition monitoring
</li>
<li>Laboratories, equipment manufacturers, oil and additive producers and electric utilities looking to monitor oil conditioning and antioxidant levels in use
</li>
</ul>
<blockquote>
Presenter: Paul Swan (Technical Manager APAC, Australian Laboratory Services, Tribology)
</blockquote>
<blockquote>
Presenter: Larry Tucker (Director of Norms and Standards, Metrohm USA)
</blockquote>
<blockquote>
Presenter: Melissa O&#39;Meara (Forensic Science Consultant, C&amp;EN Media Group)
</blockquote>

C&EN: Exploring Methods for Antioxidants, Oil & Condition Monitoring in Tribology

Exploring Methods for Antioxidants, Oil & Condition Monitoring in Tribology

Vital aspects of oil and condition monitoring and the importance of antioxidants in tribology.

Exploring Methods for Monitoring in Tribology

UV-Vis spectrophotometric analysis is vital for Pharma and Biopharma labs, advancing drug development, quality control, and research.
Explore how the Agilent Cary 3500, in synergy with OpenLab Software, conquers challenges, ensures data integrity, and maximizes productivity. Its modular design tailored to your application needs streamlines complex measurements with minimal sample preparation. With an advanced xenon flash lamp offering a 10-year replacement warranty and no warm-up time, rest assured your sensitive samples are safeguarded for reliable and cost-effective analysis.
Learning Objectives:
<ol>
<li>Overcoming Challenges with Long Pathlength Analysis
</li>
<li>Latest Technology for Solid Sample Analysis
</li>
<li>Simultaneous Measurements with Temperature Control using Multicell
</li>
<li>Simplifying Complex Measurements for Protein and Biological Samples
</li>
<li>Enhancing Laboratory Productivity, Cost Saving, and Ease of Use
</li>
<li>Achieving Data Integrity and Compliance with Global Regulations
</li>
</ol>
Who should attend?
<ul>
<li>Pharma &amp; Biopharma professionals
</li>
<li>QA/QC laboratory analysts and managers
</li>
<li>Researchers, academicians and students in Life Sciences
</li>
</ul>
<blockquote>
Presenter: Shubham Sengupta (Product Specialist – Spectroscopy, Agilent Technologies)
</blockquote>
<blockquote>
Shubham Sengupta is a Spectroscopy Product Specialist at Agilent Technologies, with 14 years of diverse experience ranging from CRO to CTL. He holds a postgraduate degree in Chemistry from Indian School of Mines, Dhanbad (IIT-Dhanbad).
</blockquote>

Agilent Technologies: Powering UV-Vis Analysis in Pharma & Biopharma: Agilent Cary 3500

Powering UV-Vis Analysis in Pharma & Biopharma: Agilent Cary 3500

Overcoming Challenges with Long Pathlength Analysis.

Powering UV-Vis Analysis in Pharma & Biopharma

In this webinar we provide an introduction to the new patented Emission Suppression Technology (EST) for the Thermo Scientific Argus VI Static Vacuum Mass Spectrometer.
EST revolutionizes noble gas isotope ratio mass spectrometry by switching off ionization during sample introduction, removing the trade-off between precision and equilibration time.
We will demonstrate how by pausing sample consumption, EST allows measurements to be made on properly equilibrated samples, resulting in dramatic improvements in both the accuracy and precision of noble gas isotope ratios. We explain the potential that this technology has for dramatically boosting signal sensitivity through modification of prep benches and sample introduction methods.
Key Learnings:
<ul>
<li>What is EST and how does it work?
</li>
<li>Impact of EST on Ar-Ar dating
</li>
<li>The future of NG-MS with EST
</li>
</ul>
<blockquote>
Presenter: Lionnel Mounier (IRMS Business Development Manager, Thermo Fisher Scientific)
</blockquote>
<blockquote>
A polar glaciologist and palaeoclimatologist by training, Lionnel has been working with isotopes for 38 years including 34 years in the commercialization of isotope ratio mass spectrometers (IRMS) and notably noble gas isotope ratio mass spectrometers (NG IRMS).
</blockquote>
<blockquote>
Presenter: Issaku Kohl (Product Manager, Thermo Fisher Scientific)
</blockquote>
<blockquote>
Issaku manages the gas IRMS, noble gas MS and Orbitrap Exploris Isotope Solutions product lines at Thermo Fisher Scientific. He is an Isotope Geo- and Cosmochemist by training and he draws on years of experience in traditional and advanced stable gas isotope applications in Earth sciences. With this background, he is now driving the development of the gas isotope MS product portfolio.
</blockquote>

Thermo Scientific: Emission Suppression Technology: Revolutionizing noble gas mass spectrometry

Emission Suppression Technology: Revolutionizing noble gas mass spectrometry

Introduction to the new patented Emission Suppression Technology (EST).

EST: : Revolutionizing noble gas mass spectrometry

Microplastics pose an alarming issue in India, as the country ranks third globally in plastic waste generation.
However, we are still at an early stage of understanding and mitigating its impact. The lack of regulatory guidelines and standardised methods leads to variations in results, hindering the comprehensive understanding of the issue. Join us as we uncover India&#39;s Microplastics problem- Challenges, Impact and Solutions. 
Gain in-depth insights and engage in discussions with our expert speakers: Dr. V Arya (a leading researcher &amp; Assistant Professor, Dept. of Environmental Engineering, IIT Delhi) will discuss:
<ul>
<li>Microplastics and their Impact on Environment and Human Health
</li>
<li>Prevalence and urgency of microplastics pollution in India
</li>
<li>Need for clear regulatory guidelines and standardized analytical solutions for characterizing microplastics in environmental samples.
</li>
</ul>
Dr. Andreas Kerstan (Product Specialist for Molecular Spectroscopy, Agilent Technologies, Germany) will present:
<ul>
<li>Agilent&#39;s innovative 8700 LDIR Chemical Imaging System, a faster and more reliable alternative for Microplastics Analysis
</li>
<li>How it outperforms traditional methods offering a fully automated workflow, high identification accuracy, repeatability, and enhanced sample throughput.
</li>
</ul>
Who Should Attend:
<ul>
<li>Environmental Researchers, 
</li>
<li>Environmental Regulators, 
</li>
<li>Professionals, and stakeholders in environmental labs and industries.
</li>
</ul>
<blockquote>
Presenter: Dr. V Arya (Assistant Professor, Dept. of Environmental Engineering, IIT Delhi)
</blockquote>
<blockquote>
Dr. Arya V is an Assistant Professor at the Indian Institute of Technology Delhi. Her research interests include the occurrence and fate of emerging contaminants in the environment and affordable technologies for wastewater treatment with a special focus on the removal of emerging contaminants.
</blockquote>
<blockquote>
Presenter: Dr. Andreas Kerstan (Product Specialist for Molecular Spectroscopy, Agilent Technologies)
</blockquote>
<blockquote>
Dr. Andreas Kerstan works as a product specialist for Molecular Spectroscopy at Agilent Technologies in Germany. After his doctorate in 2011, he started at Agilent as an application chemist for FTIR and imaging and then two years later became a product specialist for the DACH region. For 3 years now he has also been responsible for the development of the new IR-based QCL imaging system LDIR 8700, which is specialized for the analysis of microplastics.
</blockquote>

Agilent Technologies: Tackling India's Microplastics Menace: Impact and Solutions

Tackling India's Microplastics Menace: Impact and Solutions

Microplastics and their Impact on Environment and Human Health.

<h5>The Problem:</h5>Measuring viscosity is critical to knowing if your protein and formulation will be well-behaved, or if they will really disrupt the flow of things during administration. Too bad most ways of measuring viscosity take so much sample and time that no one is getting as much viscosity data as they need.<h5>The Solution:</h5>Honeybun is the only rapid microvolume viscometer that can deliver data as fast as researchers need it. Honeybun reads up to 10 samples at a time, often in less than 1 minute. Viscosity is read using single-use microfluidic consumables so only 35 µL per sample is needed while you never have to worry about clogging, cleaning, and calibrating.<h5>The Proof:</h5>Come check out what makes Honeybun the fastest microvolume viscometer that’s built for biologics. We’ll check out real-world results on antibodies and other proteins at a range of concentrations, and dive into Honeybun’s sweet accuracy, precision, and throughput from low sample volumes.<blockquote>Presenter:&nbsp;Andre Mueller, PhD (Marketing Manager, Biologic Solutions, Unchained Labs)Andre Mueller, PhD, is the Product Manager for Aunty and Honeybun at Unchained Labs, where he supports the development of biologic and gene therapy drugs. He specializes in fluorescence, static and dynamic light scattering, focusing on biophysical characterization of proteins and viral vectors. His research background spans from structural biology to plant physiology, with experience in labs across Germany, Sweden, Denmark, and the USA. Andre earned his PhD at the Carlsberg Laboratory and completed a postdoctoral fellowship at Stanford University.Moderator: Ross Walton, PhD (Sr. Applications Scientist, Unchained Labs)</blockquote>

Unchained Labs: Go with the flow for rapid viscosity results with Honeybun recording

Go with the flow for rapid viscosity results with Honeybun recording

Come check out what makes Honeybun the fastest microvolume viscometer that’s built for biologics.