The international standard ISO/IEC 17025 [1] clause 7.7.2 with regards to ensuring the validity of results, requires a laboratory to participate in proficiency testing (PT) and/or to participate in interlaboratory comparisons (ILCs) other than PT. However, no guidance as to what these other ILCs might be, or indeed how they might compare in relation to PT, is provided. This leaflet aims to outline other ILCs available, pointing out some of the limitations as compared to PT.&nbsp;There are three major types of ILCs in which a group of laboratories analyses identical portions from a homogeneous, stable test sample, with each type being characterized by its intended purpose [2,3]:<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Eurachem_Interlaboratory_comparisons_other_than_proficiency_testing_2_d9263807fb.jpg" alt="Eurachem: Interlaboratory comparisons other than proficiency testing" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Eurachem_Interlaboratory_comparisons_other_than_proficiency_testing_2_d9263807fb.jpg 245w," sizes="100vw" width="1507" height="607">A key point is that PT is an ILC that is designed to specifically evaluate the performance of participants, providing them with an infrastructure to monitor and assess the validity of their results. This is not the key purpose of the two other ILCs, and thus depending on their intended purpose they have a number of limitations that laboratories need to be aware of when using them rather than PT. Only proficiency testing should have been conducted in full compliance to the competency standard ISO/IEC 17043 [4].&nbsp;<h4>Evaluation of measurement procedure performance&nbsp;</h4>These ILCs, are designed to assess how a particular measurement procedure performs and whether it is fit for its intended purpose. These ILCs are often referred to as a ‘method performance study’ or a ‘collaborative study’ [2]. Some limitations of using such ILCs for monitoring laboratory performance as an alternative to PT are:&nbsp;<ul><li>All participants use the same measurement procedure i.e. the measurement procedure that is being validated. Unless the measurement procedure is being routinely used by the participating laboratory such an ILC will not assess the routine performance of the laboratory using their own routine measurement procedure. Nor does it enable them to compare their performance with other laboratories using alternative measurement procedures.&nbsp;</li><li>The measurement procedure is likely to be new, so participants may not have established stable procedures and quality control, so performance may not reflect routine use.&nbsp;</li><li>The report from such an ILC would not provide information on the performance of the participant, if the statistical model used makes the assumption that all laboratories perform with equal variability.</li><li>The design of the study may require the participants to assess multiple samples and/or to undertake multiple replicate analysis on the test materials. This may not be representative of the routine measurements or tests undertaken by the laboratory.&nbsp;</li><li>The conclusion of the ILC might be that the measurement procedure being assessed is not valid.&nbsp;</li></ul><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Eurachem_Interlaboratory_comparisons_other_than_proficiency_testing_3_a53ecd2f5d.jpg" alt="Eurachem: Interlaboratory comparisons other than proficiency testing" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Eurachem_Interlaboratory_comparisons_other_than_proficiency_testing_3_a53ecd2f5d.jpg 157w," sizes="100vw" width="570" height="566"><h4>Characterisation of candidate reference materials&nbsp;</h4>These are ILCs that assign a property value to a candidate reference material, usually with a stated measurement uncertainty. These are often referred to as a ‘material certification study’ [2]. Limitations of using such ILCs as an alternative to PT are:&nbsp;<ul><li>The analysis of the candidate reference material is likely to require additional care in exercising the routine measurement procedure, such as substantially more replication, and/or may require quite different reporting formats (e.g. all valid replicates instead of a mean result). Thus, such an ILC will not necessarily provide an evaluation of the performance of the laboratory based on the routine use of their measurement procedures.&nbsp;</li><li>The report from such an ILC may include the results from the participating laboratories but would not provide information on the performance of each laboratory.&nbsp;</li><li>Participating laboratories may be required to assess multiple samples and/or to undertake multiple replicate analysis on the candidate reference materials. Thus this may not be representative of the routine measurements or tests undertaken by the laboratory.&nbsp;</li></ul><h4>Other ILCs&nbsp;</h4>Some other ILCs, whilst not being conducted in full compliance of the requirements of ISO/IEC 17043, may be designed to evaluate participant performance. These would include small ILCs as defined by EA‑2/21 [5] or split sample ILCs i.e. where a portion of a single sample is sent to two or three laboratories. Whilst these ILCs are specifically designed to evaluate participant performance, they may not provide a comprehensive comparison that a PT might provide. In such cases the laboratory needs to evaluate carefully the competence of the organization managing the ILC and the suitability of the service externally provided (ISO/IEC 17025 clause 6.6).

Interlaboratory comparisons other than proficiency testing

Our Library never stops expanding. What are the most recent contributions to LabRulezICPMS Library in the week of 29th June 2026? Check out new documents from the field of spectroscopy/spectrometry and related techniques!<blockquote>👉 <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/library">SEARCH THE LARGEST REPOSITORY OF DOCUMENTS ABOUT SPECTROSCOPY/SPECTROMETRY RELATED TECHNIQUES</a></blockquote><blockquote>👉 Need info about different analytical techniques? Peek into <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/library">LabRulezLCMS</a> or <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library">LabRulezGCMS</a> libraries.</blockquote>This week we bring you application notes by Agilent Technologies and Thermo Fisher Scientific and brochure by Shimadzu!<h3>1. Agilent Technologies: Analysis of High Purity Titanium Using an <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/library?mainauthorItems=10&amp;search=9500">Agilent 9500 ICP-QQQ</a></h3>Ensuring purity and performance of titanium materials used in high-tech industries&nbsp;<ul><li>Application note</li><li><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/labrulez-bucket-strapi-h3hsga3/an_high_purity_titanium_9500_icp_qqq_5994_9024en_agilent_56ab5e943b.pdf">Full PDF for download</a></li></ul><h5>Importance of high-purity titanium and the role of ICP-QQQ&nbsp;</h5>High-purity titanium (Ti) is a critical material in high-tech industries such as semiconductor manufacturing and aerospace engineering. In semiconductor applications, Ti is widely used as a sputtering target for thin-film deposition, where even trace levels of impurities can negatively affect film uniformity, electrical properties, and device reliability. In aerospace applications, Ti is valued for its high strength-to-weight ratio and corrosion resistance, making it an ideal material for engine components and structural parts. However, any impurities can compromise the mechanical integrity and diminish the long-term performance of components, especially when operating under extreme conditions.Ensuring the reliability and functionality of Ti in these demanding environments requires precise quantification of trace impurities in the raw material. Triple quadrupole Inductively Coupled Plasma Mass Spectrometry (ICP-QQQ) provides robust suppression of spectral interferences and ultra-low detection limits (DLs), enabling accurate determination of impurities at or below the 1 mg/kg (ppm) level in the solid. This level of sensitivity is particularly important for quality control (QC) of high-purity Ti, where conventional techniques such as XRF, ICP-OES, and GD-MS lack the sensitivity and DLs.&nbsp;For unrivalled interference reduction using reactive cell gases, Agilent ICP-QQQ instruments include two unit mass (1 u) quadrupole mass filters, Q1 and Q2.1 Q1 is positioned before the collision/reaction cell (CRC) to select which ions enter the cell for reaction with the cell gas. Q2 filters ions that exit the cell before they pass to the detector. This tandem mass spectrometer (MS/MS) operation allows for unmatched control of reaction chemistry in the CRC, making the technique useful for handling intense spectral interferences, including polyatomic, doubly charged ion (M++), isobaric, and peak overlap interferences.&nbsp;Using the newly developed <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/library?mainauthorItems=10&amp;search=9500">Agilent 9500 Triple Quadrupole ICP-MS</a> featuring a Dual-Cell System (DCS) CRC and equipped with an optional m-lens, analysts can confidently analyze Ti matrix samples and verify material purity over extended measurement periods. The m-lens is designed with an optimized geometry that minimizes background signals from easily ionized elements that can deposit on interface components during long runs. This feature enables the instrument to maintain high-power, matrix-tolerant plasma conditions while achieving ultralow background equivalent concentrations (BECs), which is critical for ppt-level impurity analysis. Operating the DCS with a suitable cell gas effectively controls spectral interferences from Ti-based species (Ti²+ and TiO+ ) that impact elements like sodium (Na), magnesium (Mg), copper (Cu), and zinc (Zn). Together with the m‑lens, this approach ensures accurate measurement of trace elemental impurities, enabling compliance within stringent industry standards. The effectiveness of the m‑lens in minimizing background signals and enabling ppt‑level impurity analysis under robust plasma conditions has also been demonstrated in high-matrix applications using ICP‑QQQ.2, 3 In addition to interference control, the 9500 ICP-QQQ system’s robustness and reproducibility make it well suited for routine analysis in both research and production settings. This capability supports the continued advancement of high-tech applications that rely on ultra-clean titanium.In this study, a 200 ppm Ti solution prepared from a high-purity Ti powder was used to represent a typical sample encountered in advanced material analysis. The performance of the 9500 ICP-QQQ for quantifying trace impurities, including Na, Mg, Cu, and Zn, in a high Ti matrix was assessed through spike-recovery experiments and long-term stability tests.<h4>Conclusion&nbsp;</h4>This study demonstrated the effectiveness of the Agilent 9500 ICP-QQQ with m-lens for the ultra-trace analysis of impurity metals in high-purity titanium. By applying optimized reaction gas conditions and mass-shift techniques, spectral interferences from Ti-based species such as Ti²+ and TiO+ were successfully mitigated, enabling accurate quantification of elements like Mg, Cu, and Zn.&nbsp;The method achieved limits of quantification in the sub-ppm range for the undiluted Ti digestion solution and maintained stable ISTD signals over extended measurement periods. Spike recovery tests confirmed high accuracy and reproducibility, with most elements showing recoveries within ±10% and RSDs below 3%.&nbsp;These results confirm that the 9500 ICP-QQQ is a robust and reliable tool for quality control of high-purity Ti, supporting its critical applications in semiconductor and aerospace industries where impurity levels must be strictly controlled.<h3>2. Shimadzu: Scanning Probe Microscope /Atomic Force Microscope SPM-9700HT Plus</h3><ul><li>Brochure</li><li><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/labrulez-bucket-strapi-h3hsga3/c147_e021_4c550d3be3.pdf">Full PDF for download</a></li></ul>The Shimadzu SPM-9700HT Plus is a high-throughput scanning probe microscope (SPM) / atomic force microscope (AFM) designed for three-dimensional surface imaging and nanoscale characterization of material properties across a broad range of scientific and industrial applications. The system combines high-resolution topographical imaging with multiple AFM measurement modes, including contact, dynamic, phase, lateral force, force modulation, and force-curve measurements, while optional modules extend its capabilities to techniques such as Kelvin probe force microscopy (KPFM), magnetic force microscopy (MFM), conductive AFM, piezoresponse force microscopy (PFM), and scanning tunneling microscopy (STM). A wide selection of interchangeable scanners, environmental accessories, optical microscope units, and specialized sample holders enables the instrument to be configured for diverse analytical requirements.A major focus of the brochure is the system's emphasis on automation and ease of use through Shimadzu's Analytical Intelligence technology. Features such as Observation Navigation, NanoAssist, and the optional Cantilever Master automate instrument setup, cantilever installation, optimization of imaging parameters, and measurement workflows, allowing operators with varying levels of experience to acquire high-quality, reproducible AFM data. The redesigned control electronics and scanning system also enable high-throughput imaging and rapid physical property mapping while maintaining nanoscale resolution. In addition, the head-slide mechanism simplifies sample exchange without removing the cantilever, increasing productivity during routine measurements.Beyond surface topography, the SPM-9700HT Plus provides extensive quantitative analysis capabilities through integrated software for roughness measurements, particle analysis, cross-sectional profiling, and morphological characterization. Optional Nano 3D Mapping Fast technology extends the instrument to nanoscale mechanical property measurements by performing force-curve mapping, allowing localized evaluation of adhesion, Young's modulus, and other mechanical properties of thin films, polymers, biomaterials, and soft samples. The optional Particle Analysis Software further enables automated extraction, classification, statistical evaluation, and export of particle size and morphology data for large datasets.The brochure demonstrates the versatility of the platform through numerous application examples spanning electronics, semiconductor devices, magnetic materials, life sciences, industrial materials, batteries, polymers, nanomaterials, food science, and chemistry. Representative studies include magnetic domain imaging, organic thin-film transistor characterization, collagen and DNA visualization, live-cell imaging, lithium-ion battery electrode and separator analysis, photocatalyst surface potential measurements, polymer phase imaging, cellulose nanofiber characterization, and beer yeast morphology. Together, these examples highlight the Shimadzu SPM-9700HT Plus as a comprehensive AFM platform capable of combining rapid imaging, advanced nanoscale property mapping, and automated data analysis for both research and routine industrial quality control.<h3>3. Thermo Fisher Scientific: Enhancing Monoclonal Antibody Yield and Quality Through Automated Multi-Component Feedback Control Loops Using the MarqMetrix All-In-One Process Raman Analyzer</h3><ul><li>Application note</li><li><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/labrulez-bucket-strapi-h3hsga3/enhancing_monoclonal_antibody_an1506_en_bba763e865.pdf">Full PDF for download</a></li></ul>The application of Raman spectroscopy for real-time monitoring and control of bioreactors marks a significant advancement in bioprocessing technology. Over the past decade, its adoption has enabled tighter control of critical process parameters (CPPs), offering early indicators of process performance to ensure consistency and improve product quality. Raman spectroscopy leverages the unique vibrational signatures of molecules, allowing for highly specific detection even in complex biological matrices. This enables simultaneous, real-time monitoring of multiple CPPs, including nutrient concentrations, metabolic by-products, and cell density. As a result, users gain deep, real-time insights into cellular metabolism and can implement more dynamic, adaptive feeding strategies based on metabolic network understanding.&nbsp;Previous studies have demonstrated the negative impact of high lactate on cell health and quantity and quality of titer produced.² In this study, we demonstrate the successful implementation of process Raman analyzer for simultaneous multi-component feedback control of glucose and lactate in a bioreactor. By continuously monitoring both analytes, the feedback control loop dynamically maintained a constant total carbon concentration (glucose + lactate) at a setpoint of 2 g/L.&nbsp;This advanced carbon-source-based control strategy ensured that cellular metabolic demands were met while promoting lactate consumption toward the end of the run. As a result, lactate accumulation was significantly reduced, leading to substantial improvements in titer yield, product quality, and cell viability compared to standard bolus feeding strategies (Figure 2).The outcomes of this work underscore the <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/products/2233">Thermo Scientific™ MarqMetrix™ All-In-One Process Raman Analyzer </a>as a key Process Analytical Technology (PAT) tool-enabling real-time, multi-analyte control for any biomanufacturer seeking to engage in intelligent, automated biomanufacturing.<h4>Conclusion&nbsp;</h4><h5>1. Unmatched Real-Time Control Capability:&nbsp;</h5>Maintaining a constant total carbon concentration (glucose + lactate) of 2 g/L in dynamic bioreactor environments demands precise, simultaneous analyte monitoring. The MarqMetrix All-In-One Process Raman Analyzer delivers near real-time, high-fidelity data every two minutes, empowering advanced control strategies that are simply not feasible with conventional technologies. This makes it an indispensable PAT tool for modern bioprocessing.&nbsp;<h5>2. Proven Impact on Product Yield and Quality:&nbsp;</h5>The Raman-enabled carbon control strategy resulted in a &gt;10% increase in titer and a reduction in glycation by 83% and 66% compared to continuous and fed-batch glucose control, respectively. These outcomes underscore the analyzer’s transformative impact on both product quantity and quality.&nbsp;<h5>3. Versatile Automation Across Bioprocesses:&nbsp;</h5>All three bioreactor runs—each employing distinct control logics (Table 2)—were successfully managed through automated feedback using the process Raman analyzer. Its flexible design, including easily swappable probes, supports seamless adaptation to other critical metabolites such as amino acids, making it a universal solution for bioprocess control.&nbsp;<h5>4. Foundation for Intelligent Manufacturing:&nbsp;</h5>With its real-time, data-rich insights and seamless integration into automated systems, the MarqMetrix All-InOne analyzer is not just a monitoring tool; it is a cornerstone technology for intelligent, AI-driven biomanufacturing. It enables consistent, high-quality production while reducing time, cost, and variability.

News from LabRulezICPMS Library - Week 27, 2026

Scientists from CEITEC Brno University of Technology led by Markéta Kaiser have achieved a globally unique breakthrough in coral research. Using the live microCT method, they were able, for the first time ever, to observe the growth of living marine corals in real time and reveal the processes behind the formation of their calcium carbonate skeletons, which had previously remained hidden beneath the surface. The results of the international study, published in the prestigious journal Science Advances, show how corals grow, regenerate, and respond to stress and competing organisms.The <a target="_blank" rel="noopener noreferrer" href="https://www.science.org/doi/10.1126/sciadv.aee3183">study</a> was carried out through a collaboration between researchers from Brno, Vienna, and several other international institutions. A key role was played by the X-ray Micro and Nano Computed Tomography Laboratory (CTLAB) at CEITEC BUT, where all the crucial data and three-dimensional coral models were produced. CEITEC also shares both the first and corresponding authorship of the study.“Thanks to live microCT, we were able, for the first time, to observe what happens beneath the surface of a coral skeleton,” explains Markéta Kaiser from CTLAB at CEITEC BUT. “For example, we witnessed situations where a coral, after being attacked by algae, completely halted its normal growth and began building a protective wall around the threatened area. Once the danger had passed, it was able to resume its original growth pattern.”<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/CEITEC_Zivi_korali_jezdili_vlakem_z_Vidne_do_Brna_Vedci_diky_nim_odhalili_jejich_tajny_zivot_540e183e84.jpeg" alt="CEITEC BUT/Jakub Rozboud: Live Corals Traveled by Train from Vienna to Brno. Scientists Uncovered Their Secret Life: Markéta Kaiser, CTLAB CEITEC at CEITEC BUT." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_CEITEC_Zivi_korali_jezdili_vlakem_z_Vidne_do_Brna_Vedci_diky_nim_odhalili_jejich_tajny_zivot_540e183e84.jpeg 235w," sizes="100vw" width="1600" height="1067">The scientists successfully captured coral growth both vertically and horizontally, the formation of protective barriers against competing organisms, and regeneration mechanisms following damage.The research was exceptionally demanding from a technological standpoint. The team had to develop a special system that enabled living corals to be safely scanned directly in seawater. The coral colonies regularly traveled by train from Vienna to Brno for measurements and, after several hours, were transported back to professional aquarium systems in Vienna.“At first, it seemed like a somewhat crazy idea. No one knew whether living corals could withstand repeated scanning,” says Kaiser. “Gradually, however, we found that they survived, continued to grow, and provided us with unique data.”<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/CEITEC_Zivi_korali_jezdili_vlakem_z_Vidne_do_Brna_Vedci_diky_nim_odhalili_jejich_tajny_zivot_2_fcbb29a4f6.jpeg" alt="CEITEC BUT/Jakub Rozboud: Live Corals Traveled by Train from Vienna to Brno. Scientists Uncovered Their Secret Life: Markéta Kaiser is placing a coral sample into CT for scanning." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_CEITEC_Zivi_korali_jezdili_vlakem_z_Vidne_do_Brna_Vedci_diky_nim_odhalili_jejich_tajny_zivot_2_fcbb29a4f6.jpeg 235w," sizes="100vw" width="1600" height="1067">The original concept for the project came from developmental biologist Igor Adameyko of the Medical University of Vienna, who proposed combining marine biology with advanced imaging technologies more commonly used in engineering and technical fields.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/CEITEC_Zivi_korali_jezdili_vlakem_z_Vidne_do_Brna_Vedci_diky_nim_odhalili_jejich_tajny_zivot_3_8c5f376f41.jpeg" alt="CEITEC BUT/Markéta Kaiser: Live Corals Traveled by Train from Vienna to Brno. Scientists Uncovered Their Secret Life: Corals CT - 1." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_CEITEC_Zivi_korali_jezdili_vlakem_z_Vidne_do_Brna_Vedci_diky_nim_odhalili_jejich_tajny_zivot_3_8c5f376f41.jpeg 228w," sizes="100vw" width="1600" height="1096">The findings of the Brno researchers have already attracted the attention of experts in Okinawa, Japan, who specialize in coral reef research. They plan to use the live microCT method to study the effects of light, photosynthesis, and environmental changes on coral growth.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/CEITEC_Zivi_korali_jezdili_vlakem_z_Vidne_do_Brna_Vedci_diky_nim_odhalili_jejich_tajny_zivot_4_445c1cc3b7.jpeg" alt="CEITEC BUT/Markéta Kaiser: Live Corals Traveled by Train from Vienna to Brno. Scientists Uncovered Their Secret Life:Corals CT - 2." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_CEITEC_Zivi_korali_jezdili_vlakem_z_Vidne_do_Brna_Vedci_diky_nim_odhalili_jejich_tajny_zivot_4_445c1cc3b7.jpeg 245w," sizes="100vw" width="1600" height="988">According to the researchers, the project demonstrates the importance of interdisciplinary collaboration between engineering and biological sciences. The research could contribute not only to the study and conservation of coral reefs, but also to fields such as paleontology and materials science.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/CEITEC_Zivi_korali_jezdili_vlakem_z_Vidne_do_Brna_Vedci_diky_nim_odhalili_jejich_tajny_zivot_5_514ee9c974.jpg" alt="CEITEC BUT/Markéta Kaiser: Live Corals Traveled by Train from Vienna to Brno. Scientists Uncovered Their Secret Life: Corals CT - 3." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_CEITEC_Zivi_korali_jezdili_vlakem_z_Vidne_do_Brna_Vedci_diky_nim_odhalili_jejich_tajny_zivot_5_514ee9c974.jpg 143w," sizes="100vw" width="1600" height="1750"><blockquote><h4>Original Article</h4><h4><a target="_blank" rel="noopener noreferrer" href="https://www.science.org/doi/10.1126/sciadv.aee3183">Coral growth, retraction, defense, and regenerative strategies revealed by live microCT</a></h4>Karina Araslanova, Marketa Kaiser, Anton Fetisov, Diana Gavrik, Tomas Zikmund, Daniel Abed-Navandi, Karel Katovský, Jozef Kaiser, Igor AdameykoSci. Adv., 2026, 12, eaee3183<a target="_blank" rel="noopener noreferrer" href="https://doi.org/10.1126/sciadv.aee3183">https://doi.org/10.1126/sciadv.aee3183</a><h6>licenced under <a target="_blank" rel="noopener noreferrer" href="https://creativecommons.org/licenses/by/4.0/">CC-BY 4.0</a></h6></blockquote><h4>Abstract</h4>Understanding how corals build and remodel their skeletons is key to explaining reef resilience, yet most insights come from static imaging. Using longitudinal live microCT, we tracked the same coral colonies over weeks to months at micrometer resolution. Coral skeleton formation is not a uniform accretion process but a dynamic integration of multiple programs, including vertical and horizontal patterned growth, previously undescribed defensive wall-building against competitors, exploratory edge behavior with reversible expansions and retractions, and skeletal regeneration favoring rapid, imprecise yet effective matrix expansion. Time-resolved imaging links colony-scale growth to microscale events, showing that all modes depend on balances between fusion of skeletal microparticles and layered matrix deposition, guided by tissue prepatterning. Beyond corals, this framework generalizes to studying skeletal dynamics across diverse biomineralizing organisms.

Live Corals Traveled by Train from Vienna to Brno. Scientists Uncovered Their Secret Life 

Article

Application

Academy

Science and research

Since its establishment in 2011, CEITEC has quickly developed into a cutting-edge infrastructure for research which performs highly alongside the best institutes in Europe. Among the main priorities of CEITEC are the promotion of a motivating and dynamic international scientific environment, the provision of state-of-the-art research infrastructure, and the policy of open communication and equal opportunities.

CEITEC

Eurachem is a European network promoting international traceability of chemical measurements and good analytical practice. It provides expert guidance, supports method validation, uncertainty evaluation, proficiency testing, and facilitates discussion on technical and policy issues in analytical quality.

Eurachem

Everything from the world of analytical chemistry in one place. We connect people in solving their problems. At Labrulez you will find all the necessary information easily, quickly and clearly. Stop searching and start finding.

LabRulez

Agilent Technologies

Technology Networks

Unchained Labs

Bruker

Thermo Fisher Scientific

PerkinElmer

SelectScience

C&EN

Shimadzu Corporation

TBS... Elemental Analysis of Lithium-ion Battery Samples using ICP-OES and ICP-MS
<blockquote>
Presenter: L. Craig Jones (ICP-MS Application Scientist, Agilent Technologies, Inc.)
</blockquote>
<blockquote>
Craig has been with Agilent for over 15 years as an ICP-MS applications scientist. He has been involved with multiple type of applications for ICP-MS, including environmental, pharmaceutical, semiconductor, geologic, and clinical analyses, to name a few. Previous to Agilent he worked in an environmental lab performing analysis and supervising both the inorganic and organic sections of the laboratory. In his spare time, Craig enjoys volunteering at the local marine science center, mountain biking, hiking, and relaxing at the beach. Craig obtained a Bachelor of Science degree in chemistry from Fort Lewis College in Durango, CO.
</blockquote>
<blockquote>
Presenter: Sima Singha, PhD (ICP-OES Application Scientist, Atomic Spectroscopy, Agilent Technologies, Inc.)
</blockquote>
<blockquote>
Sima has over fifteen years of hands on experience as an applications scientist in the field of atomic spectroscopy. Before joining Agilent in 2017, managed an agricultural chemistry laboratory for the analysis of water, soil, and plant tissue digests using ICP-OES for various EPA methods. She received a Ph.D. degree in Chemistry from the University of Illinois at Chicago with numerous peer-reviewed publications.
</blockquote>

Agilent Technologies: Elemental Analysis of Lithium-ion Battery Samples using ICP-OES and ICP-MS

Elemental Analysis of Lithium-ion Battery Samples using ICP-OES and ICP-MS

Lithium-ion Batteries Analysis using ICP-OES and ICP-MS

TBS... Agilent M Lens for ICP-MS and the Semiconductor Industry
<blockquote>
Presenter: Bert Woods (Application Scientist, Agilent Technologies, Inc.)
</blockquote>
<blockquote>
Joined the Agilent ICP-MS team in 2004, with previous employment in the semiconductor industry with Dominion Semiconductor (IBM/Toshiba) and Micron. Bert is a 1997 Chemistry graduate of Radford University in Virginia and an avid Washington DC Sports fan.
</blockquote>

Agilent technologies: Agilent M Lens for ICP-MS and the Semiconductor Industry

Agilent M Lens for ICP-MS and the Semiconductor Industry

Digitalizing laboratory sample workflows is crucial yet challenging due to complex data types, resource constraints, and the need for integration, automation, training, and more.
But with CaliberLIMS, these challenges become opportunities. CaliberLIMS is a robust, scalable, and reliable platform designed to meet the demands of modern laboratories aiming for Pharma 4.0.
With the upgraded version, CaliberLIMS 4.0 enables users to effortlessly adopt a futuristic workflow that integrates instruments, workflows, and data across the entire laboratory. Packed with powerful features, this advanced software can enhance compliance, integrity, and productivity, making your laboratory tomorrow-ready.
Register now to secure your spot!
Learning Objectives:
<ul>
<li>Learn how LIMS application can accelerate laboratory efficiency </li>
<li>Explore how digitalization can be made easier with scalable solutions </li>
<li>Understand how to achieve seamless integrations with CaliberLIMS for automated workflows</li>
<li>Discover the latest advancements in Caliber 4.0</li>
</ul>
<blockquote>
Presenter: Kanimozhi Sivarajan (Informatics Manager, Shimadzu (Asia Pacific) Pte Ltd)
</blockquote>
<blockquote>
Dr. Kani is having 10 years of experince in Laboratory Management and Informatics Systems. She is serving as Informatics Manager at Shimadzu Asia Pacific, Singapore, providing Lab Informatics Solutions such as LabSolutions CS, LIMS and other QMS applications. She is supporting customers from various segments on implementing laboratory automation and responsible for providing consultation on streamlining Lab Workflows, Regulatory Compliance requirements for Electronic Data Management and Lab Practices/Analysis. 
</blockquote>

Shimadzu: Elevating Pharma 4.0: Harnessing CaliberLIMS For Digital Excellence

Elevating Pharma 4.0: Harnessing CaliberLIMS For Digital Excellence

CaliberLIMS is a robust, scalable, and reliable platform designed to meet the demands of modern laboratories aiming for Pharma 4.0.

 Pharma 4.0: CaliberLIMS For Digital Excellence

<h4>Unraveling Epigenetic Changes in Cancer Cells</h4>
During this webinar, guest speaker Dr. Babak Faryabi, University of Pennsylvania, discusses utilizing Oligopaint and super-resolution microscopy to investigate the role of transcription hubs in altering genome folding.
Attendees can expect to learn about the power of super-resolution microscopy and chromatin tracing in understanding the three-dimensional structure of the genome in single cells.
The importance of epigenetic changes in cancer pathogenesis has become increasingly clear, yet the underlying mechanisms remain obscure. Our research focuses on identifying epigenetic changes that can render cancer cells addicted to specific transcriptional regulators. I will present evidence that oncogenic subversion of transcription factors leads to disruption of chromosome topology and instruct enhancer elements to aberrantly interact and activate intact key proto-oncogenes. These aberrant epigenetic states can drive cancer cell growth and proliferation in the absence of genetic mutations and may also confer drug resistance. I will also discuss our efforts to develop single-cell molecular tools and experimental models to characterize epigenetic mechanisms of oncogenesis and attendant therapeutic opportunities.
<blockquote>
Presenter: Babak Faryabi, Ph.D. (Associate Professor of Pathology and Cancer Biology, University of Pennsylvania Perelman School of Medicine)
</blockquote>
<blockquote>
Dr. Faryabi has a distinguished history of research and accomplishments in cancer epigenomics. His work has significantly advanced our understanding of how transcription factors alter cancer genome folding. By conducting the first genome-wide and single-cell resolution measurement of genome looping in triple-negative breast cancer (TNBC) and mantle cell lymphoma (MCL), he discovered that Notch can regulate gene expression by changing genome folding and bringing together distant enhancer and promoter elements on the linear genome. This identified a novel mechanism by which oncogenic Notch alters transcription. Furthermore, he uncovered that Notch-dependent DNA loops bring multiple genomic elements into highly interacting spatial hubs of enhancers and promoters. He is among the first to elucidate the contribution of genome topology organization to cancer therapy resistance. His work revealed the role of genome folding reorganization as a novel epigenetic adaptation mechanism, conferring resistance to Notch inhibitors in T-cell leukemia and to BTK inhibitors in B cell lymphoma. To achieve his central scientific objective, he also innovates machine learning tools and software to better dissect the complexity and heterogeneity of genome structures and regulation in cancer.
</blockquote>
<blockquote>
As the faculty lead at the Center for Personalized Diagnostics at the Hospital of the University of Pennsylvania, his clinical expertise lies in developing genomic assays for diagnostic and predictive markers in cancer.
</blockquote>

Bruker: Notch-Mutated Cancer Genomes in 3D

Notch-Mutated Cancer Genomes in 3D

Find out what super-resolution microscopy can reveal about epigenetic changes in cancer pathogenesis.

In an effort to build smarter factories, many industry leaders have started moving the point-of-analysis from the laboratory to process.
Clearly actionable data generated by Process Analytical Technology (PAT) makes this paradigm shift possible. PAT not only enhances Predictive Maintenance (PdM) by detecting issues early and minimizing downtime, it also supports Statistical Process Control (SPC) through real-time monitoring and optimization, and improves Quality by Design (QbD) with better process understanding and risk management.
In this webinar, Chad Shade, Global PAT Team Leader, will share how Albemarle Corporation approached the implementation of Spectroscopy PAT to obtain smarter process operations and what you can do to help drive a mindset change in your business. Elena Hagemann, Product Manager for Process Spectroscopy, will introduce the newest spectroscopy technologies for real-time, non-destructive analysis that further support sustainability initiatives.
Key Learning Objectives:
<ul>
<li>Staying Competitive: Attendees will gain knowledge that can give them an edge over competitors who may not be leveraging these advanced technologies.
</li>
<li>Enhanced Process Understanding: Attendees will learn how Spectroscopy PAT can be applied to optimize processes, ensuring better quality and efficiency.
</li>
<li>Managing Expectations: Attendees will discover practical tips on fostering a culture shift within their organization to embrace advanced Spectroscopy PAT solutions.
</li>
<li>Actionable Strategies: Attendees will learn the steps and considerations to successfully implement Spectroscopy PAT for enhanced process operations.
</li>
<li>Innovation: Attendees will explore the latest spectroscopy technologies that enable real-time, non-destructive analysis and support sustainability initiatives.
</li>
</ul>
Who Should Attend:
<ul>
<li>Production manager / Operational manager/ Plant manager
</li>
<li>Process engineers
</li>
<li>Product development scientists
</li>
<li>Quality control specialists
</li>
</ul>
<blockquote>
Presenter: Chad Shade (Global Process Analytical Team Leader, Albemarle Corporation)
</blockquote>
<blockquote>
Preenter: Elena Hagemann (Spectroscopy Product Manager, Process Analytics, Metrohm USA)
</blockquote>
<blockquote>
Presenter: Kelly McSweeney (Contributing Editor, C&amp;EN Media Group)
</blockquote>

CEN: Smart and Actionable: Spectroscopy PAT-Supported Process Operations

Smart and Actionable: Spectroscopy PAT-Supported Process Operations

How Albemarle Corporation approached the implementation of Spectroscopy PAT to obtain smarter process operations.

Smart and Actionable: Spectroscopy PAT-Supported Process

Adeno-associated vectors (AAVs) are transforming therapeutics – from gene therapy to vaccines.
A major challenge when developing AAV-based therapeutics is ensuring that empty AAVs that lack therapeutic DNA are removed, increasing the efficacy of the product.
But the empty AAVs are chemically identical to their full counterparts, making this process complicated. Enter mass photometry, a new bioanalytical technique that can efficiently characterize AAVs and distinguish between full and empty AAVs.
This webinar explores how mass photometry can circumvent challenges associated with AAVs, helping to accelerate therapeutic development and manufacturing.
Attend this webinar to: 
<ul>
<li>Discover how mass photometry is currently being used in industry</li>
<li>Learn how mass photometry can accurately measure empty/full AAV capsid ratios</li>
<li>Explore how to integrate mass photometry in a GMP-regulated environment</li>
</ul>
Will I receive a certificate of attendance?
Yes, when attending the webinar, you will be able to download a certificate of attendance from the literature section.
Will the webinar be available to watch On-Demand?
Yes, after the live date the recording will be available to watch. Once registered, you will receive an email notifying you when the recording is available along with your on-demand link.
<ul>
<li>Presenter: Dr. Matt Ranaghan (Senior Applications Scientist, Refeyn)</li>
</ul>

Technology Networks: Enhancing the Development of AAV-Based Therapeutics With Mass Photometry

Enhancing the Development of AAV-Based Therapeutics With Mass Photometry

Mass photometry, a new bioanalytical technique that can efficiently characterize AAVs and distinguish between full and empty AAVs.

Development of AAV-Based Therapeutics With Mass Photometry

In this webinar, Caroline Roe, Managing Director, Cancer and Immunology Core, Vanderbilt University, will give a broad overview of available high-dimensional flow cytometry technologies and reagents, how they work, and an experience-informed breakdown of the strengths and limitations of each technique. She will review considerations for choosing the appropriate high-dimensional flow cytometry technology for a project. In addition, she will provide guidance for those who have experience in one technology and are transitioning to another.
Key topics discussed in this webinar will include:
<ul>
<li>An overview of high-dimensional flow cytometry technologies and reagents</li>
<li>Considerations for choosing the appropriate high-dimensional flow cytometry technology for a project</li>
<li>Guidance for those who are transitioning to a new flow cytometry technology</li>
</ul>
Who should attend?
<ul>
<li>Flow cytometry novices who wish to learn more about high-dimensional flow cytometry</li>
<li>Experienced flow cytometrists who are new to high-dimensional flow cytometry</li>
<li>Anyone seeking to have a deeper understanding of high-dimensional flow technologies</li>
</ul>
Certificate of attendance
All webinar participants can request a certificate of attendance, including a learning outcomes summary, for continuing education purposes.
<blockquote>
Presenter: Caroline E. Roe, MLI (Managing Director, Cancer and Immunology Core, Vanderbilt University)
</blockquote>
<blockquote>
Caroline Roe received her BS.c. in Genetics, Cell Biology, and Development from the University of Minnesota-Twin Cities, and Master of Laboratory Investigation from Vanderbilt University in Nashville, Tennessee, where she has managed the Mass Cytometry Center of Excellence since its inception in 2017. As director of the Cancer and Immunology Core, her focus is on increasing both the standardization and accessibility of cutting-edge cytometry techniques for application across a broad range of basic and translational research projects.
</blockquote>
<blockquote>
Moderator: Charlie Carter (Associate Editor, SelectScience)
</blockquote>

SelectScience: Improving Results Through Better Understanding: A Primer On High-Dimensional Flow Cytometry Technologies And Reagents

Improving Results Through Better Understanding: A Primer On High-Dimensional Flow Cytometry Technologies And Reagents

A broad overview of available high-dimensional flow cytometry technologies and reagents.

A Primer On High-Dimensional Flow Cytometry Technologies

High matrix samples, such as those containing high dissolved solids, can often be challenging potentially resulting in poor data quality and instrument performance, leading to excess maintenance.
In this webinar we will discuss the techniques available to deal with these samples.
<blockquote>
Presenter: David Fishwick (Applications Specialist, TEA, Thermo Fisher Scientific)
</blockquote>
<blockquote>
David joined Thermo in 2022 as an Applications Specialist for the Trace Elemental Analysis product range in the UK and Ireland. Prior to joining Thermo, David has gained experience of trace elemental analysis and chromatography in industry, working in GMP, GLP and UKAS accrediated R&amp;D and pharmaceutical laboratories. David holds a BSc in Chemistry from Bangor University.
</blockquote>
<blockquote>
Presenter: Matthew Gregory (Applications Specialist, TEA, Thermo Fisher Scientific)
</blockquote>
<blockquote>
After graduating from the University of Surrey with an MChem in Chemistry, Matthew has gained 20 years’ experience of trace elemental analysis in industry, working in environmental and precious metal research laboratories. In 2018, Matthew joined Thermo Fisher Scientific as an Applications Specialist for the Trace Elemental Analysis product range in the UK and Ireland.
</blockquote>

Thermo Scientific: Dealing with the Complexity of High Matrix Samples on ICP-OES and ICP-MS

Dealing with the Complexity of High Matrix Samples on ICP-OES and ICP-MS

Techniques available to deal with these samples.

Complexity of High Matrix Samples ICP-OES amd ICP-MS

Rice fortification is a cost-effective solution for addressing nutritional challenges by adding Iron, Folic acid, and Vitamin B12. Our innovative Equipment offers robust and reliable performance with high sensitivity and throughput, able to test for challenging samples and analytes.
This webinar offers valuable insights into the latest advancements in analytical testing for fortified rice, catering to food manufacturers, regulatory agencies, and research institutions.

PerkinElmer: Fortify Rice in a compliant way

Fortify Rice in a compliant way

Valuable insights into the latest advancements in analytical testing for fortified rice.

<h5>The Problem</h5>Characterizing ADCs can feel like reinventing the wheel when methods aren’t flexible enough to keep up with high-throughput analysis of different antibody-drug combinations or reaction conditions. ADC characterization usually involves a combination of several HPLC methods, but HPLC often takes too long, requires too much sample, or needs too much optimization to work with every candidate.<h5>The Solution</h5>Stunner makes high-throughput reads on 2 μL of sample to gather three key datapoints on up to 96 ADCs at-a-time. Keep an eye on antibody concentration, check the drug-antibody ratio (DAR), and watch out for aggregation – all in only two minutes per sample.<h5>The Proof</h5>In this seminar, we’ll show how Stunner characterized 6 model ADCs created from 1 mAb and 3 payload/linker combinations reacted at 2 molar ratios. We’ll explain how Stunner’s Unmix algorithms break down UV/Vis absorbance spectra into their component parts to quantify total protein and drug payload. We’ll also show how flexible that analysis is when it is taught new user-created reference spectra.<blockquote>Presenter: Andree Mueller (Senior Product Manager for Aunty and Honeybun, Unchained Labs)Presenter:&nbsp;Kevin Lance, PhD (Director, Product Management, Unchained Labs)Kevin Lance directs product management and covers the Stunner portfolio globally at Unchained Labs. His expertise includes biophysical characterization of viral vectors, lipid nanoparticles, proteins, and nucleic acids. Prior to Unchained Labs, his research experience covered the fields of sustained antibody delivery and nanotechnology. He earned his Ph.D. in Bioengineering from the joint UC Berkeley – UCSF Bioengineering Graduate Program.</blockquote>

Unchained Labs: Lose the lag with high-throughput and flexible ADC analysis on Stunner

Lose the lag with high-throughput and flexible ADC analysis on Stunner

Learn how Stunner enables rapid ADC characterization—measuring concentration, DAR, and aggregation from 2 μL samples in minutes, across up to 96 ADCs.