The international standard ISO/IEC 17025 [1] clause 7.7.2 with regards to ensuring the validity of results, requires a laboratory to participate in proficiency testing (PT) and/or to participate in interlaboratory comparisons (ILCs) other than PT. However, no guidance as to what these other ILCs might be, or indeed how they might compare in relation to PT, is provided. This leaflet aims to outline other ILCs available, pointing out some of the limitations as compared to PT.&nbsp;There are three major types of ILCs in which a group of laboratories analyses identical portions from a homogeneous, stable test sample, with each type being characterized by its intended purpose [2,3]:<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Eurachem_Interlaboratory_comparisons_other_than_proficiency_testing_2_d9263807fb.jpg" alt="Eurachem: Interlaboratory comparisons other than proficiency testing" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Eurachem_Interlaboratory_comparisons_other_than_proficiency_testing_2_d9263807fb.jpg 245w," sizes="100vw" width="1507" height="607">A key point is that PT is an ILC that is designed to specifically evaluate the performance of participants, providing them with an infrastructure to monitor and assess the validity of their results. This is not the key purpose of the two other ILCs, and thus depending on their intended purpose they have a number of limitations that laboratories need to be aware of when using them rather than PT. Only proficiency testing should have been conducted in full compliance to the competency standard ISO/IEC 17043 [4].&nbsp;<h4>Evaluation of measurement procedure performance&nbsp;</h4>These ILCs, are designed to assess how a particular measurement procedure performs and whether it is fit for its intended purpose. These ILCs are often referred to as a ‘method performance study’ or a ‘collaborative study’ [2]. Some limitations of using such ILCs for monitoring laboratory performance as an alternative to PT are:&nbsp;<ul><li>All participants use the same measurement procedure i.e. the measurement procedure that is being validated. Unless the measurement procedure is being routinely used by the participating laboratory such an ILC will not assess the routine performance of the laboratory using their own routine measurement procedure. Nor does it enable them to compare their performance with other laboratories using alternative measurement procedures.&nbsp;</li><li>The measurement procedure is likely to be new, so participants may not have established stable procedures and quality control, so performance may not reflect routine use.&nbsp;</li><li>The report from such an ILC would not provide information on the performance of the participant, if the statistical model used makes the assumption that all laboratories perform with equal variability.</li><li>The design of the study may require the participants to assess multiple samples and/or to undertake multiple replicate analysis on the test materials. This may not be representative of the routine measurements or tests undertaken by the laboratory.&nbsp;</li><li>The conclusion of the ILC might be that the measurement procedure being assessed is not valid.&nbsp;</li></ul><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Eurachem_Interlaboratory_comparisons_other_than_proficiency_testing_3_a53ecd2f5d.jpg" alt="Eurachem: Interlaboratory comparisons other than proficiency testing" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Eurachem_Interlaboratory_comparisons_other_than_proficiency_testing_3_a53ecd2f5d.jpg 157w," sizes="100vw" width="570" height="566"><h4>Characterisation of candidate reference materials&nbsp;</h4>These are ILCs that assign a property value to a candidate reference material, usually with a stated measurement uncertainty. These are often referred to as a ‘material certification study’ [2]. Limitations of using such ILCs as an alternative to PT are:&nbsp;<ul><li>The analysis of the candidate reference material is likely to require additional care in exercising the routine measurement procedure, such as substantially more replication, and/or may require quite different reporting formats (e.g. all valid replicates instead of a mean result). Thus, such an ILC will not necessarily provide an evaluation of the performance of the laboratory based on the routine use of their measurement procedures.&nbsp;</li><li>The report from such an ILC may include the results from the participating laboratories but would not provide information on the performance of each laboratory.&nbsp;</li><li>Participating laboratories may be required to assess multiple samples and/or to undertake multiple replicate analysis on the candidate reference materials. Thus this may not be representative of the routine measurements or tests undertaken by the laboratory.&nbsp;</li></ul><h4>Other ILCs&nbsp;</h4>Some other ILCs, whilst not being conducted in full compliance of the requirements of ISO/IEC 17043, may be designed to evaluate participant performance. These would include small ILCs as defined by EA‑2/21 [5] or split sample ILCs i.e. where a portion of a single sample is sent to two or three laboratories. Whilst these ILCs are specifically designed to evaluate participant performance, they may not provide a comprehensive comparison that a PT might provide. In such cases the laboratory needs to evaluate carefully the competence of the organization managing the ILC and the suitability of the service externally provided (ISO/IEC 17025 clause 6.6).

Interlaboratory comparisons other than proficiency testing

Our Library never stops expanding. What are the most recent contributions to LabRulezICPMS Library in the week of 29th June 2026? Check out new documents from the field of spectroscopy/spectrometry and related techniques!<blockquote>👉 <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/library">SEARCH THE LARGEST REPOSITORY OF DOCUMENTS ABOUT SPECTROSCOPY/SPECTROMETRY RELATED TECHNIQUES</a></blockquote><blockquote>👉 Need info about different analytical techniques? Peek into <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/library">LabRulezLCMS</a> or <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library">LabRulezGCMS</a> libraries.</blockquote>This week we bring you application notes by Agilent Technologies and Thermo Fisher Scientific and brochure by Shimadzu!<h3>1. Agilent Technologies: Analysis of High Purity Titanium Using an <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/library?mainauthorItems=10&amp;search=9500">Agilent 9500 ICP-QQQ</a></h3>Ensuring purity and performance of titanium materials used in high-tech industries&nbsp;<ul><li>Application note</li><li><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/labrulez-bucket-strapi-h3hsga3/an_high_purity_titanium_9500_icp_qqq_5994_9024en_agilent_56ab5e943b.pdf">Full PDF for download</a></li></ul><h5>Importance of high-purity titanium and the role of ICP-QQQ&nbsp;</h5>High-purity titanium (Ti) is a critical material in high-tech industries such as semiconductor manufacturing and aerospace engineering. In semiconductor applications, Ti is widely used as a sputtering target for thin-film deposition, where even trace levels of impurities can negatively affect film uniformity, electrical properties, and device reliability. In aerospace applications, Ti is valued for its high strength-to-weight ratio and corrosion resistance, making it an ideal material for engine components and structural parts. However, any impurities can compromise the mechanical integrity and diminish the long-term performance of components, especially when operating under extreme conditions.Ensuring the reliability and functionality of Ti in these demanding environments requires precise quantification of trace impurities in the raw material. Triple quadrupole Inductively Coupled Plasma Mass Spectrometry (ICP-QQQ) provides robust suppression of spectral interferences and ultra-low detection limits (DLs), enabling accurate determination of impurities at or below the 1 mg/kg (ppm) level in the solid. This level of sensitivity is particularly important for quality control (QC) of high-purity Ti, where conventional techniques such as XRF, ICP-OES, and GD-MS lack the sensitivity and DLs.&nbsp;For unrivalled interference reduction using reactive cell gases, Agilent ICP-QQQ instruments include two unit mass (1 u) quadrupole mass filters, Q1 and Q2.1 Q1 is positioned before the collision/reaction cell (CRC) to select which ions enter the cell for reaction with the cell gas. Q2 filters ions that exit the cell before they pass to the detector. This tandem mass spectrometer (MS/MS) operation allows for unmatched control of reaction chemistry in the CRC, making the technique useful for handling intense spectral interferences, including polyatomic, doubly charged ion (M++), isobaric, and peak overlap interferences.&nbsp;Using the newly developed <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/library?mainauthorItems=10&amp;search=9500">Agilent 9500 Triple Quadrupole ICP-MS</a> featuring a Dual-Cell System (DCS) CRC and equipped with an optional m-lens, analysts can confidently analyze Ti matrix samples and verify material purity over extended measurement periods. The m-lens is designed with an optimized geometry that minimizes background signals from easily ionized elements that can deposit on interface components during long runs. This feature enables the instrument to maintain high-power, matrix-tolerant plasma conditions while achieving ultralow background equivalent concentrations (BECs), which is critical for ppt-level impurity analysis. Operating the DCS with a suitable cell gas effectively controls spectral interferences from Ti-based species (Ti²+ and TiO+ ) that impact elements like sodium (Na), magnesium (Mg), copper (Cu), and zinc (Zn). Together with the m‑lens, this approach ensures accurate measurement of trace elemental impurities, enabling compliance within stringent industry standards. The effectiveness of the m‑lens in minimizing background signals and enabling ppt‑level impurity analysis under robust plasma conditions has also been demonstrated in high-matrix applications using ICP‑QQQ.2, 3 In addition to interference control, the 9500 ICP-QQQ system’s robustness and reproducibility make it well suited for routine analysis in both research and production settings. This capability supports the continued advancement of high-tech applications that rely on ultra-clean titanium.In this study, a 200 ppm Ti solution prepared from a high-purity Ti powder was used to represent a typical sample encountered in advanced material analysis. The performance of the 9500 ICP-QQQ for quantifying trace impurities, including Na, Mg, Cu, and Zn, in a high Ti matrix was assessed through spike-recovery experiments and long-term stability tests.<h4>Conclusion&nbsp;</h4>This study demonstrated the effectiveness of the Agilent 9500 ICP-QQQ with m-lens for the ultra-trace analysis of impurity metals in high-purity titanium. By applying optimized reaction gas conditions and mass-shift techniques, spectral interferences from Ti-based species such as Ti²+ and TiO+ were successfully mitigated, enabling accurate quantification of elements like Mg, Cu, and Zn.&nbsp;The method achieved limits of quantification in the sub-ppm range for the undiluted Ti digestion solution and maintained stable ISTD signals over extended measurement periods. Spike recovery tests confirmed high accuracy and reproducibility, with most elements showing recoveries within ±10% and RSDs below 3%.&nbsp;These results confirm that the 9500 ICP-QQQ is a robust and reliable tool for quality control of high-purity Ti, supporting its critical applications in semiconductor and aerospace industries where impurity levels must be strictly controlled.<h3>2. Shimadzu: Scanning Probe Microscope /Atomic Force Microscope SPM-9700HT Plus</h3><ul><li>Brochure</li><li><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/labrulez-bucket-strapi-h3hsga3/c147_e021_4c550d3be3.pdf">Full PDF for download</a></li></ul>The Shimadzu SPM-9700HT Plus is a high-throughput scanning probe microscope (SPM) / atomic force microscope (AFM) designed for three-dimensional surface imaging and nanoscale characterization of material properties across a broad range of scientific and industrial applications. The system combines high-resolution topographical imaging with multiple AFM measurement modes, including contact, dynamic, phase, lateral force, force modulation, and force-curve measurements, while optional modules extend its capabilities to techniques such as Kelvin probe force microscopy (KPFM), magnetic force microscopy (MFM), conductive AFM, piezoresponse force microscopy (PFM), and scanning tunneling microscopy (STM). A wide selection of interchangeable scanners, environmental accessories, optical microscope units, and specialized sample holders enables the instrument to be configured for diverse analytical requirements.A major focus of the brochure is the system's emphasis on automation and ease of use through Shimadzu's Analytical Intelligence technology. Features such as Observation Navigation, NanoAssist, and the optional Cantilever Master automate instrument setup, cantilever installation, optimization of imaging parameters, and measurement workflows, allowing operators with varying levels of experience to acquire high-quality, reproducible AFM data. The redesigned control electronics and scanning system also enable high-throughput imaging and rapid physical property mapping while maintaining nanoscale resolution. In addition, the head-slide mechanism simplifies sample exchange without removing the cantilever, increasing productivity during routine measurements.Beyond surface topography, the SPM-9700HT Plus provides extensive quantitative analysis capabilities through integrated software for roughness measurements, particle analysis, cross-sectional profiling, and morphological characterization. Optional Nano 3D Mapping Fast technology extends the instrument to nanoscale mechanical property measurements by performing force-curve mapping, allowing localized evaluation of adhesion, Young's modulus, and other mechanical properties of thin films, polymers, biomaterials, and soft samples. The optional Particle Analysis Software further enables automated extraction, classification, statistical evaluation, and export of particle size and morphology data for large datasets.The brochure demonstrates the versatility of the platform through numerous application examples spanning electronics, semiconductor devices, magnetic materials, life sciences, industrial materials, batteries, polymers, nanomaterials, food science, and chemistry. Representative studies include magnetic domain imaging, organic thin-film transistor characterization, collagen and DNA visualization, live-cell imaging, lithium-ion battery electrode and separator analysis, photocatalyst surface potential measurements, polymer phase imaging, cellulose nanofiber characterization, and beer yeast morphology. Together, these examples highlight the Shimadzu SPM-9700HT Plus as a comprehensive AFM platform capable of combining rapid imaging, advanced nanoscale property mapping, and automated data analysis for both research and routine industrial quality control.<h3>3. Thermo Fisher Scientific: Enhancing Monoclonal Antibody Yield and Quality Through Automated Multi-Component Feedback Control Loops Using the MarqMetrix All-In-One Process Raman Analyzer</h3><ul><li>Application note</li><li><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/labrulez-bucket-strapi-h3hsga3/enhancing_monoclonal_antibody_an1506_en_bba763e865.pdf">Full PDF for download</a></li></ul>The application of Raman spectroscopy for real-time monitoring and control of bioreactors marks a significant advancement in bioprocessing technology. Over the past decade, its adoption has enabled tighter control of critical process parameters (CPPs), offering early indicators of process performance to ensure consistency and improve product quality. Raman spectroscopy leverages the unique vibrational signatures of molecules, allowing for highly specific detection even in complex biological matrices. This enables simultaneous, real-time monitoring of multiple CPPs, including nutrient concentrations, metabolic by-products, and cell density. As a result, users gain deep, real-time insights into cellular metabolism and can implement more dynamic, adaptive feeding strategies based on metabolic network understanding.&nbsp;Previous studies have demonstrated the negative impact of high lactate on cell health and quantity and quality of titer produced.² In this study, we demonstrate the successful implementation of process Raman analyzer for simultaneous multi-component feedback control of glucose and lactate in a bioreactor. By continuously monitoring both analytes, the feedback control loop dynamically maintained a constant total carbon concentration (glucose + lactate) at a setpoint of 2 g/L.&nbsp;This advanced carbon-source-based control strategy ensured that cellular metabolic demands were met while promoting lactate consumption toward the end of the run. As a result, lactate accumulation was significantly reduced, leading to substantial improvements in titer yield, product quality, and cell viability compared to standard bolus feeding strategies (Figure 2).The outcomes of this work underscore the <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/products/2233">Thermo Scientific™ MarqMetrix™ All-In-One Process Raman Analyzer </a>as a key Process Analytical Technology (PAT) tool-enabling real-time, multi-analyte control for any biomanufacturer seeking to engage in intelligent, automated biomanufacturing.<h4>Conclusion&nbsp;</h4><h5>1. Unmatched Real-Time Control Capability:&nbsp;</h5>Maintaining a constant total carbon concentration (glucose + lactate) of 2 g/L in dynamic bioreactor environments demands precise, simultaneous analyte monitoring. The MarqMetrix All-In-One Process Raman Analyzer delivers near real-time, high-fidelity data every two minutes, empowering advanced control strategies that are simply not feasible with conventional technologies. This makes it an indispensable PAT tool for modern bioprocessing.&nbsp;<h5>2. Proven Impact on Product Yield and Quality:&nbsp;</h5>The Raman-enabled carbon control strategy resulted in a &gt;10% increase in titer and a reduction in glycation by 83% and 66% compared to continuous and fed-batch glucose control, respectively. These outcomes underscore the analyzer’s transformative impact on both product quantity and quality.&nbsp;<h5>3. Versatile Automation Across Bioprocesses:&nbsp;</h5>All three bioreactor runs—each employing distinct control logics (Table 2)—were successfully managed through automated feedback using the process Raman analyzer. Its flexible design, including easily swappable probes, supports seamless adaptation to other critical metabolites such as amino acids, making it a universal solution for bioprocess control.&nbsp;<h5>4. Foundation for Intelligent Manufacturing:&nbsp;</h5>With its real-time, data-rich insights and seamless integration into automated systems, the MarqMetrix All-InOne analyzer is not just a monitoring tool; it is a cornerstone technology for intelligent, AI-driven biomanufacturing. It enables consistent, high-quality production while reducing time, cost, and variability.

News from LabRulezICPMS Library - Week 27, 2026

Scientists from CEITEC Brno University of Technology led by Markéta Kaiser have achieved a globally unique breakthrough in coral research. Using the live microCT method, they were able, for the first time ever, to observe the growth of living marine corals in real time and reveal the processes behind the formation of their calcium carbonate skeletons, which had previously remained hidden beneath the surface. The results of the international study, published in the prestigious journal Science Advances, show how corals grow, regenerate, and respond to stress and competing organisms.The <a target="_blank" rel="noopener noreferrer" href="https://www.science.org/doi/10.1126/sciadv.aee3183">study</a> was carried out through a collaboration between researchers from Brno, Vienna, and several other international institutions. A key role was played by the X-ray Micro and Nano Computed Tomography Laboratory (CTLAB) at CEITEC BUT, where all the crucial data and three-dimensional coral models were produced. CEITEC also shares both the first and corresponding authorship of the study.“Thanks to live microCT, we were able, for the first time, to observe what happens beneath the surface of a coral skeleton,” explains Markéta Kaiser from CTLAB at CEITEC BUT. “For example, we witnessed situations where a coral, after being attacked by algae, completely halted its normal growth and began building a protective wall around the threatened area. Once the danger had passed, it was able to resume its original growth pattern.”<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/CEITEC_Zivi_korali_jezdili_vlakem_z_Vidne_do_Brna_Vedci_diky_nim_odhalili_jejich_tajny_zivot_540e183e84.jpeg" alt="CEITEC BUT/Jakub Rozboud: Live Corals Traveled by Train from Vienna to Brno. Scientists Uncovered Their Secret Life: Markéta Kaiser, CTLAB CEITEC at CEITEC BUT." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_CEITEC_Zivi_korali_jezdili_vlakem_z_Vidne_do_Brna_Vedci_diky_nim_odhalili_jejich_tajny_zivot_540e183e84.jpeg 235w," sizes="100vw" width="1600" height="1067">The scientists successfully captured coral growth both vertically and horizontally, the formation of protective barriers against competing organisms, and regeneration mechanisms following damage.The research was exceptionally demanding from a technological standpoint. The team had to develop a special system that enabled living corals to be safely scanned directly in seawater. The coral colonies regularly traveled by train from Vienna to Brno for measurements and, after several hours, were transported back to professional aquarium systems in Vienna.“At first, it seemed like a somewhat crazy idea. No one knew whether living corals could withstand repeated scanning,” says Kaiser. “Gradually, however, we found that they survived, continued to grow, and provided us with unique data.”<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/CEITEC_Zivi_korali_jezdili_vlakem_z_Vidne_do_Brna_Vedci_diky_nim_odhalili_jejich_tajny_zivot_2_fcbb29a4f6.jpeg" alt="CEITEC BUT/Jakub Rozboud: Live Corals Traveled by Train from Vienna to Brno. Scientists Uncovered Their Secret Life: Markéta Kaiser is placing a coral sample into CT for scanning." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_CEITEC_Zivi_korali_jezdili_vlakem_z_Vidne_do_Brna_Vedci_diky_nim_odhalili_jejich_tajny_zivot_2_fcbb29a4f6.jpeg 235w," sizes="100vw" width="1600" height="1067">The original concept for the project came from developmental biologist Igor Adameyko of the Medical University of Vienna, who proposed combining marine biology with advanced imaging technologies more commonly used in engineering and technical fields.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/CEITEC_Zivi_korali_jezdili_vlakem_z_Vidne_do_Brna_Vedci_diky_nim_odhalili_jejich_tajny_zivot_3_8c5f376f41.jpeg" alt="CEITEC BUT/Markéta Kaiser: Live Corals Traveled by Train from Vienna to Brno. Scientists Uncovered Their Secret Life: Corals CT - 1." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_CEITEC_Zivi_korali_jezdili_vlakem_z_Vidne_do_Brna_Vedci_diky_nim_odhalili_jejich_tajny_zivot_3_8c5f376f41.jpeg 228w," sizes="100vw" width="1600" height="1096">The findings of the Brno researchers have already attracted the attention of experts in Okinawa, Japan, who specialize in coral reef research. They plan to use the live microCT method to study the effects of light, photosynthesis, and environmental changes on coral growth.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/CEITEC_Zivi_korali_jezdili_vlakem_z_Vidne_do_Brna_Vedci_diky_nim_odhalili_jejich_tajny_zivot_4_445c1cc3b7.jpeg" alt="CEITEC BUT/Markéta Kaiser: Live Corals Traveled by Train from Vienna to Brno. Scientists Uncovered Their Secret Life:Corals CT - 2." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_CEITEC_Zivi_korali_jezdili_vlakem_z_Vidne_do_Brna_Vedci_diky_nim_odhalili_jejich_tajny_zivot_4_445c1cc3b7.jpeg 245w," sizes="100vw" width="1600" height="988">According to the researchers, the project demonstrates the importance of interdisciplinary collaboration between engineering and biological sciences. The research could contribute not only to the study and conservation of coral reefs, but also to fields such as paleontology and materials science.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/CEITEC_Zivi_korali_jezdili_vlakem_z_Vidne_do_Brna_Vedci_diky_nim_odhalili_jejich_tajny_zivot_5_514ee9c974.jpg" alt="CEITEC BUT/Markéta Kaiser: Live Corals Traveled by Train from Vienna to Brno. Scientists Uncovered Their Secret Life: Corals CT - 3." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_CEITEC_Zivi_korali_jezdili_vlakem_z_Vidne_do_Brna_Vedci_diky_nim_odhalili_jejich_tajny_zivot_5_514ee9c974.jpg 143w," sizes="100vw" width="1600" height="1750"><blockquote><h4>Original Article</h4><h4><a target="_blank" rel="noopener noreferrer" href="https://www.science.org/doi/10.1126/sciadv.aee3183">Coral growth, retraction, defense, and regenerative strategies revealed by live microCT</a></h4>Karina Araslanova, Marketa Kaiser, Anton Fetisov, Diana Gavrik, Tomas Zikmund, Daniel Abed-Navandi, Karel Katovský, Jozef Kaiser, Igor AdameykoSci. Adv., 2026, 12, eaee3183<a target="_blank" rel="noopener noreferrer" href="https://doi.org/10.1126/sciadv.aee3183">https://doi.org/10.1126/sciadv.aee3183</a><h6>licenced under <a target="_blank" rel="noopener noreferrer" href="https://creativecommons.org/licenses/by/4.0/">CC-BY 4.0</a></h6></blockquote><h4>Abstract</h4>Understanding how corals build and remodel their skeletons is key to explaining reef resilience, yet most insights come from static imaging. Using longitudinal live microCT, we tracked the same coral colonies over weeks to months at micrometer resolution. Coral skeleton formation is not a uniform accretion process but a dynamic integration of multiple programs, including vertical and horizontal patterned growth, previously undescribed defensive wall-building against competitors, exploratory edge behavior with reversible expansions and retractions, and skeletal regeneration favoring rapid, imprecise yet effective matrix expansion. Time-resolved imaging links colony-scale growth to microscale events, showing that all modes depend on balances between fusion of skeletal microparticles and layered matrix deposition, guided by tissue prepatterning. Beyond corals, this framework generalizes to studying skeletal dynamics across diverse biomineralizing organisms.

Live Corals Traveled by Train from Vienna to Brno. Scientists Uncovered Their Secret Life 

Article

Application

Academy

Science and research

Since its establishment in 2011, CEITEC has quickly developed into a cutting-edge infrastructure for research which performs highly alongside the best institutes in Europe. Among the main priorities of CEITEC are the promotion of a motivating and dynamic international scientific environment, the provision of state-of-the-art research infrastructure, and the policy of open communication and equal opportunities.

CEITEC

Eurachem is a European network promoting international traceability of chemical measurements and good analytical practice. It provides expert guidance, supports method validation, uncertainty evaluation, proficiency testing, and facilitates discussion on technical and policy issues in analytical quality.

Eurachem

Everything from the world of analytical chemistry in one place. We connect people in solving their problems. At Labrulez you will find all the necessary information easily, quickly and clearly. Stop searching and start finding.

LabRulez

Metrohm

Mettler-Toledo

Agilent Technologies

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Thermo Fisher Scientific

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Wiley

<ul>
<li>Learn the various optical performance parameters</li>
<li>Learn which parameters need to be monitored</li>
<li>Benefits of automated performance qualification</li>
<li>Solution for data integrity compliance in optical instrument qualification</li>
<li>Overview of available service offerings from METTLER TOLEDO</li>
</ul>
During the webinar, we will go into depth about these questions and more:
<h5>What certified reference materials (CRMs) are specified for wavelength accuracy and precision tests by both Pharmacopeias?</h5>
USP: Rare earth oxide solutions/glasses (Ce, Ho, Didymium) or Hg/D2 emission lines
Ph. Eur.: Ho(ClO4)3, Ce2(SO4)3 solutions, or Ho/Didymium glasses, or Hg, D2, Ne, Xe lines
<h5>What CRMs are specified for photometric accuracy and precision tests by both Pharmacopeias?</h5>
USP: for UV range, Nicotinic acid in HCl (6 – 60 mg/L, up to 2.5 A, 213 and 261 nm) or K2Cr2O7 in HClO4 (6 – 200 mg/L, up to 3.0 A, 235, 257, 313, 350 nm); for visible range, neutral density glass filters (up to 3.5 A, 440, 465, 546.1, 590, and 635 nm)
Ph. Eur.: Suitable solid and liquid filters such as certified PDC or neutral density filters; or, instead of certified PDC, Nicotinic acid in HCl.
<h5>What CRMs are specified for photometric linearity tests by both Pharmacopeias?</h5>
USP and Ph. Eur., respectively, specify to use the materials for photometric accuracy tests also for photometric linearity tests.
<h5>Target Audience</h5>
Lab Managers, Lab Technicians, System Owners, Quality Assurance Managers, Quality Assurance Operators
<blockquote>
Presenter: Dr. Fabian Müller (Product Manager SPG UV/VIS)
</blockquote>
<blockquote>
Presenter: Dr. Hans-Joachim Muhr (Business Development Manager BioTech)
</blockquote>

METTLER TOLEDO: Pharmacopeia – What to Check on UV Vis Spectrophotometers? 

Pharmacopeia – What to Check on UV Vis Spectrophotometers? 

USP and Ph. Eur. Requirements Placed on UV/Vis Spectrophotometers

Pharmacopeia – What to Check on UV Vis Spectrophotometers?

As part of the global effort to reduce CO₂ emissions, biofuels are becoming an increasingly important source of green energy.
Quality control testing of biofuels is therefore crucial to ensure the efficiency and reliability of biogas, biodiesel, and fuel ethanol. 
In this webinar you will learn about the latest laboratory testing techniques that are used to ensure the quality, efficiency, and sustainability of modern biofuels to enable producers to confidently meet international regulatory requirements and to promote their widespread adoption in both industry and the wider society at large. 
Experts from Agilent Technologies will introduce a wide range of analytical testing solutions covering multiple technologies that are routinely used to detect organic and inorganic impurities in biodiesel and enable the stringent quality control of fuel ethanol, biogas and biogas blends to be achieved. The expert panel will be available to answer questions from the audience at the end of the presentation. 
<blockquote>
Presenter: Danny van Oevelen (LC Product Specialist, Agilent Technologies)
</blockquote>
<blockquote>
Presenter: Luca Godina (GC &amp; GC/MS Application Specialist, Agilent Technologies)
</blockquote>
<blockquote>
Presenter: Sebastien Sannac (Spécialiste produit spectroscopie atomique, Agilent Technologies)
</blockquote>
<blockquote>
Presenter: Donald Inglis (Product Specialist EMEAI for FTIR, Agilent Technologies)
</blockquote>
<blockquote>
Presenter: Remko van Loon (GC &amp; GC/MS Product Specialist, Agilent Technologies)
</blockquote>

Agilent Technologies: Comprehensive Quality Control Testing of Biofuels to Ensure a Greener, more Sustainable Future

Comprehensive Quality Control Testing of Biofuels to Ensure a Greener, more Sustainable Future

Learn about the latest laboratory testing techniques that are used to ensure the quality, efficiency, and sustainability of modern biofuels.

Comprehensive Quality Control Testing of Biofuels

X-ray Fluorescence (XRF) spectrometry is a widely used analytical technology for the determination of elemental concentrations in various sample types (liquids, powders, granules, solids, …). Key benefits of XRF include high precision &amp; accuracy, ease-of-use, and short time-to-result. The required sample preparation is minimal compared to alternative technologies like ICP-OES. Even though XRF sample preparation is fast and simple, doing it right is pivotal for using XRF successfully, especially for high-throughput industrial applications. By choosing the appropriate preparation approach and following certain best practice steps, you can save time and money while ensuring the necessary data quality.
Which foil should I use for which liquid? Do I need to polish my sample? When should I grind, press or fuse a sample? And why? 
These and more questions will be answered.
Register now to learn about optimal sample preparation for XRF! 
In our lab sessions, we will show valuable tips and tricks for various applications and materials. Our experts will answer your questions during our Q&amp;A session.
<h5>Agenda (60 min)</h5>
<ul>
<li>Basics of Sample Preparation</li>
<li>Lab Session 1: Liquid Samples</li>
<li>Lab Session 2: Powders &amp; Pellets</li>
<li>The Effect of Grain Size, Pressing and Matrix </li>
<li>Lab Session 3: Fused Beads </li>
<li>Lab Session 4: Small Spot &amp; Mapping</li>
<li>Q&amp;A Session with our Experts</li>
</ul>
<h5>Best practice examples will be provided for:</h5>
<ul>
<li>All Techniques and Sample Types</li>
<li>Mining &amp; Cement</li>
<li>Petrochemicals &amp; Polymers</li>
<li>RoHS Analysis (Small Spot)</li>
<li>Defect Analysis (Mapping) </li>
<li>and more …</li>
</ul>
<h5>Who should attend?</h5>
<ul>
<li>QA Managers</li>
<li>Head of Laboratories </li>
<li>Consultants</li>
<li>Lab Technicians</li>
<li>Researchers</li>
</ul>
<blockquote>
Presenter: Dr. Kai Behrens (Head of XRF Product Line Management, Bruker AXS)
</blockquote>
<blockquote>
Presenter: Dr. Adrian Fiege (Product Manager XRF, Bruker AXS)
</blockquote>
<blockquote>
Presenter: Renata Janjic (Application Scientist XRF, Bruker AXS)
</blockquote>
<blockquote>
Presenter: Frank Portala (Product Manager XRF, Bruker AXS)
</blockquote>

Bruker: XRF Unveiled: Mastering the Art of Sample Preparation

XRF Unveiled: Mastering the Art of Sample Preparation

We will show valuable tips and tricks for various applications and materials. Our experts will answer your questions during our Q&A session.

In this webinar, a panel of expert speakers will explore the advancements of the QBD 1200 Plus, a cutting-edge new instrument in the field of total organic carbon (TOC) analysis.&nbsp;Hosted by Beckman Coulter Life Sciences, this roundtable event will feature insights from industry experts who will discuss the evolution of the QBD 1200, the improvements in nondispersive infrared (NDIR) stability, and the features of the QBD 1200 Plus. Attendees will have the opportunity to engage with the panel, ask questions, and learn how the QBD 1200 Plus is setting new standards in TOC analysis for various applications, including pharmaceutical and industrial use. Join us for an in-depth discussion on how Beckman Coulter Life Sciences continues to lead the way in reliable and high-performance TOC analysis technology.<h5>Key learning objectives</h5><ul><li>Understand the evolution of TOC analysis technology &nbsp;</li><li>Explore the improvements in NDIR stability &nbsp;</li><li>Learn about the innovative features of the QbD 1200 Plus</li></ul><h5>Who should attend?</h5><ul><li>QC/QA managers, Facility directors, Regulatory specialists, GMP professionals, QC analysts, microbiologists, training and production managers interested in GMP compliance and global regulations, tools, and techniques.</li></ul><blockquote>Presenter: Kyran Page (Current System engineer, Beckman Coulter Life Sciences) Presenter:&nbsp;Matt Chausseau (Senior Technical Product Manager, Beckman Coulter Life Sciences) Presenter:&nbsp;Carrie Haslam (Associate Editor, SelectScience)</blockquote>

SelectScience: The future of TOC analysis

The future of TOC analysis

The advancements of the QBD 1200 Plus, a cutting-edge new instrument in the field of total organic carbon (TOC) analysis.

Join our expert application scientist to learn about the&nbsp;new features available in the TruScan G3 for pharmaceutical and biotechnology manufacturing QA/QC.Discover how the new Thermo Scientific™ TruScan™ G3 Handheld Raman Analyzer uses Raman spectroscopy to perform accurate and reliable material identification at the point of need, minimizing the need for costly and time-consuming laboratory sampling tests.<h4>You will learn:</h4><ul><li>How to stay compliant with 21CFR Part11 requirements</li><li>The backwards compatibility with Thermo Scientific™ TruScan™ RM methods</li><li>The patented superior algorithm</li><li>New features and capabilities available in the TruScan G3</li></ul><h5>Who should attend:</h5><ul><li>Quality Control Professionals</li><li>Process Analytics Professionals</li><li>Quality Assurance Professionals</li></ul><blockquote>Presenter: Kathy RosalinaKathy Rosalina is a Product Applications Engineer at Thermo Fisher Scientific, responsible for the technical and applications support for Portable Analytical Instruments in raw materials verification, counterfeit detection, and PAT control. Kathy has a decade of experience in the use of vibrational spectroscopy and chemometric analysis for a wide range of application areas in pharma, biotech, and chemical industries. She has extensive knowledge in implementation and validation of handheld instruments in pharmaceutical customers.</blockquote>

Thermo Scientific: Discover the next generation of raw material ID testing for QA/QC

Discover the next generation of raw material ID testing for QA/QC

Learn about the new features available in the TruScan G3 for pharmaceutical and biotechnology manufacturing QA/QC.

Discover the next generation of raw material ID testing

Join Agilent and GERSTEL for a 3-day live virtual seminar discussing how you can assure safety, authenticity, and quality of alcoholic beverages. The focus will be on sharing the latest in technology developments and capabilities, new applications, and customer stories.<h4>Presentation 1: Use of FTIR Technology for the Analysis of Sugars and Sweeteners in the Production of Alcoholic Beverages</h4><ul><li>Rogelio García Juárez, Pre-Sales Application Engineer – Agilent Technologies</li></ul>Currently, fast, and accurate methods are required for the analysis of raw materials and various sources to produce alcoholic beverages, for the rapid identification and quantification of these materials, let's review FTIR technology for process controls, as the ideal alternative to other techniques such as HPLC.<h5>Key Learning Objectives/What attendees will learn:</h5>1. The use of Fourier Transform Infrared (FTIR) Technology in applications for the alcoholic beverage industry.2. Analysis for the identification and release of raw materials used in preparation of Spirits.3. Quick methods to determine the concentration of sugars and sweeteners for process control.<h5>Who Should Attend:</h5><ul><li>Producers of alcoholic beverages, distillates, prepared liqueurs, juices, and extracts.</li></ul><h4>Presentation 2: GC-MS Techniques for the Determination of 2-Methylisoborneol and Geosmin in Finished Whiskey</h4><ul><li>Nicole Kfoury, Applications Scientist, GERSTEL,Inc.</li></ul>2-Methylisoborneol (MIB) and geosmin are naturally occurring metabolites formed by bacteria and fungi, most often in surface water sources. They have musty/earthy odors and very low odor thresholds, meaning they can be smelled at concentrations of 1-10 ppt in water. As a result, products, such as whiskey, that use contaminated water in the process may have musty, earthy odors in the finished product. Due to the complexity of the whiskey matrix and the low odor threshold of MIB and geosmin, they can be challenging to quantify accurately. This work shows that a selectable, heartcutting 1D/2D-GC-MSD is required to accurately quantify MIB and geosmin in finished whiskey. &nbsp;<h5>Key Learning Objectives/What attendees will learn:</h5>1. Overview of solid phase microextraction (SPME) versus stir bar sorptive extraction (SBSE).2. Overview of multidimensional, heartcutting GC-MS.3. How to accurately measure the concentration of 2-methylisoborneol and geosmin in complex samples such as whiskey.<h5>Who Should Attend:</h5><ul><li>Analytical chemists in the food, flavor, fragrance, and beverage industries.</li></ul><blockquote>Presnter: Rogelio García Juárez (Pre-Sales Application Engineer, Agilent Technologies)Rogelio García is an Applications Engineer for Molecular Spectroscopy in UV-Vis, FTIR, and Raman techniques at Agilent México and Latin America. Rogelio has a Bachelor’s Degree in Pharmaceutical Chemistry and a Master´s Degree in Environmental Engineering. He has worked in several developments of methods and applications in water, soil, and air, as well as in method design for the Pharmaceutical and Food industry. In this last one, he has developed an outstanding application method for alcoholic beverages such as Tequila using FTIR technology.Presnter:&nbsp;Nicole Kfoury, Ph.D. (Applications Scientist, GERSTEL, Inc.)Dr. Nicole Kfoury is an Applications Scientist at GERSTEL, Inc. in Baltimore, MD. She joined GERSTEL after receiving her Ph.D. in Analytical Chemistry at Tufts University and working as a Research Scientist at the Tufts University Sensory and Science Center. She is responsible for developing methods for sample preparation and gas chromatography-mass spectrometry and creating a Sensory Directed Analysis program at GERSTEL. She teaches customer training, supports pre- and post-sales opportunities, and provides analytical support to customers in a wide array of industries including food, flavor, fragrance, forensic, environmental, and chemical industries.</blockquote>

Agilent Technologies: Alcoholic Beverages Virtual Symposium: Spirits

Alcoholic Beverages Virtual Symposium: Spirits

How you can assure safety, authenticity, and quality of alcoholic beverages.

Wiley Surface-to-Spectral Analysis software provides a comprehensive, powerful solution to process, combine, and analyze images and data from multiple microscopic techniques.Designed to make your lab more efficient and analyses more thorough, from a single interface you can perform: &nbsp;• &nbsp;Spectral Processing and Analysis&nbsp; • &nbsp;Spectral Map and Image Processing&nbsp; • &nbsp;Correlative Analysis&nbsp; • &nbsp;3D Visualization of 2D Compositional DataWiley Surface-to-Spectral Analysis also integrates with Wiley’s KnowItAll software,* enabling users to search against spectral libraries for further investigation. In this session, we will introduce Wiley Surface-to-Spectral Analysis and demonstrate how to accelerate your surface analysis workflow by processing and analyzing a hyperspectral image. &nbsp;This session is recommended for:• &nbsp;Materials scientists, life scientists, and chemists who are involved in surface analysis and/or are interested in learning more about Wiley Surface-to-Spectral Analysis capabilities. &nbsp;&nbsp; • &nbsp;Professors and students engaged in chemistry and surface analysis courses or lab work.<blockquote>Presenter: Dr. Leanna Ergin (Associate Editor, Wiley Science Solutions)Presenter:&nbsp;Michelle D’Souza (Product Manager, Software Products)</blockquote>

Wiley: Introduction to Wiley Surface-to-Spectral Analysis: Go from microscopy to spectral analysis in a single workflow

Introduction to Wiley Surface-to-Spectral Analysis: Go from microscopy to spectral analysis in a single workflow

How to accelerate your surface analysis workflow by processing and analyzing a hyperspectral image.

Introduction to Wiley Surface-to-Spectral Analysis

Ion chromatography (IC) hyphenated with inductively coupled plasma mass spectrometry (ICP-MS) – IC-ICP-MS is the preferred solution for speciation analyses of trace elements such as chromium, arsenic, selenium, or mercury.In this webinar we focus on some key features of the integration of Metrohm IC with Agilent’s MassHunter software for ICP-MS. Based on practical examples such as chromium speciation according to ISO 24384, we demonstrate the benefits of bi-directional communication, real-time status updates, and a single, consolidated sample list streamlining your trace elemental analysis with a single-software solution.<h4>Key learnings of this webinar:</h4><ul><li>Learn why IC is the method of choice for the separation of ionic components for subsequent quantification with ICP-MS</li><li>Explore the features that make Agilent ICP-MS a superior choice for speciation analysis</li><li>Understand the streamlined workflow for chromium speciation according to ISO 24384 using MassHunter ICP-MS</li><li>Understand the added value of inline sample preparation techniques available with Metrohm IC</li></ul><h4>Who should attend?</h4><ul><li>Laboratory managers, analytical chemists, researchers doing trace elemental analysis</li></ul><blockquote>Presenter: Dr. Elke Süss (Application Specialist Ion Chromatography, Metrohm International Headquarters)Elke Süss received a M.Sc. in Geoecology and a Ph.D. in Environmental Geochemistry in 2011 from Bayreuth University, Germany. After a position as laboratory manager at Bayreuth University, she worked as a Research Assistant and then PostDoc at ETH Zürich and Eawag focusing on trace elemental speciation and has more than 10 years of experience with IC-ICP-MS in this field. In 2018, she joined the Ion Chromatography team at Metrohm International Headquarters in Switzerland as an Application Specialist. &nbsp;Presenter:&nbsp;Andrew Brotherhood (Atomic Spectroscopy Application Engineer, Agilent UK)Andrew has over 15 years’ hands-on experience with ICP-MS, ICP-OES and Ion chromatography instrumentation. He has mainly worked in the pharmaceutical analysis industry gaining significant experience with developing and validating methods to pharma regulations.Andrew started working for Agilent as a full-time employee in January 2018 working as an Atomic Spectroscopy Application Engineer based at the Agilent Centre of Excellence in the UK.</blockquote>

Metrohm: Simplify your speciation analysis: Metrohm ion chromatography meets Agilent ICP-MS

Simplify your speciation analysis: Metrohm ion chromatography meets Agilent ICP-MS

Key features of the integration of Metrohm IC with Agilent’s MassHunter software for ICP-MS.

Metrohm ion chromatography meets Agilent ICP-MS

UV-Vis spectroscopy is a cornerstone analytical technique in the pharmaceutical industry, widely employed for its versatility and reliability serving essential functions such as the synthesis of drug compounds, purity assessment, dissolution profiling, and the analysis of biomolecules throughout the drug development process. This technique is pivotal for ensuring the quality and efficacy of pharmaceutical products. However, the pharmaceutical industry faces several challenges with traditional UV-Vis spectroscopy, such as the need for stringent regulatory compliance, the demand for high precision and accuracy, and the requirement for efficient data management systems to handle the vast amount of data generated.The Agilent Cary 3500 UV-Vis model addresses these pain points effectively, join the webinar to discover how this cutting-edge instrument elevates the standards of pharmaceutical analysis with its unique features and seamless OpenLab integration.Key Takeaways:<ul><li>Innovative Temperature Control: Learn how the Cary 3500’s precise temperature control accelerates your analytical processes.</li><li>Rapid Data Acquisition: Understand the impact of high-speed data collection on your research outcomes.</li><li>Small-Volume Mastery: Explore the instrument’s proficiency in small-volume analysis, ensuring accuracy down to the minutest quantities.</li><li>Highest Absorbance Range: Explore the Cary 3500’s superior absorbance range for unparalleled sensitivity in your measurements.</li><li>OpenLab Server Connectivity: Experience the seamless data management and integrity that OpenLab server-based connectivity provides, meeting stringent regulatory compliance.</li><li>Interactive Q&amp;A Session: Engage with our experts to address your queries and discuss the instrument’s application in real-world pharmaceutical scenarios.</li></ul><blockquote>Presenter: Ms. Vijaya Jyothi (Product Specialist - Spectroscopy, Agilent Technologies)Vijaya Jyothi is a seasoned product specialist at Agilent Technologies. She manages the spectroscopy division, having extensive expertise in spectroscopy applications across diverse industries, offering deep insights and solutions tailored to varied analytical needs.</blockquote>

Agilent: Cary 3500 UV-VIS Advanced Analytical Capabilities and Seamless Server Connectivity

Cary 3500 UV-VIS Advanced Analytical Capabilities and Seamless Server Connectivity

Discover how this cutting-edge instrument elevates the standards of pharmaceutical analysis with its unique features and seamless OpenLab integration.

Cary 3500 UV-VIS Advanced Capabilities

As subcutaneous delivery of high-concentration biologics becomes more popular, optimizing their formulations becomes more complicated. Some excipients play better with one antibody, not another, or only help under specific conditions. Testing formulations at high protein concentration makes lower sample consumption and efficient assays a must-have. High-throughput, low volume solutions, designed for biologics, will speed up those formulation studies. Here, we present a case study on how to prepare monoclonal antibodies at high and low concentrations with some common excipients and screen for effects on quality, stability, and viscosity.The case study will illustrate how to produce all this data seamlessly, allowing the researcher to rate and rank formulations for their influence on the analyte and to quickly narrow down the optimal excipients.<blockquote>Presenter: Ross Walton (Senior Application Scientist, Analytics, Unchained Labs)Moderator:&nbsp;Chloe (Oxford Global)</blockquote>

Unchained Labs: Fast track formulation with biologics screening in a snap

Fast track formulation with biologics screening in a snap

Explore how to optimize high-concentration biologic formulations using low-volume, high-throughput tools. Case study shows impact on quality, stability.

Cary 3500 UV-VIS Advanced Analytical Capabilities and Seamless Server Connectivity

Simplify your speciation analysis: Metrohm ion chromatography meets Agilent ICP-MS

Introduction to Wiley Surface-to-Spectral Analysis: Go from microscopy to spectral analysis in a single workflow

Pharmacopeia – What to Check on UV Vis Spectrophotometers?

Fast track formulation with biologics screening in a snap

Alcoholic Beverages Virtual Symposium: Spirits

Discover the next generation of raw material ID testing for QA/QC

The future of TOC analysis

Comprehensive Quality Control Testing of Biofuels to Ensure a Greener, more Sustainable Future

XRF Unveiled: Mastering the Art of Sample Preparation

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