<h4><strong>The problem&nbsp;</strong></h4><p>We live in a “global village” but we are all different and we use many different languages to communicate.&nbsp;</p><p>Even when people speak the same language, the same words may be used with different meanings. See, for example, some different uses of the word “standard” in English – a normative document, a solution of known concentration or even a type of flag.&nbsp;</p><p>Even in the same area of activity misunderstandings do occur which may result in a waste of time and money, or even worse consequences.&nbsp;</p><p>When talking about laboratory tests, lack of a full understanding of key terms and inappropriate translations leaves room for different interpretations of stated requirements. For example, there have historically been a number of different but related uses of the term ‘<strong>detection limit’</strong>. This may lead to inadequate fulfilment of those requirements, thus becoming an obstacle to the production of analytical data that is fit for its intended use. A shared interpretation of concepts related to quality in measurement between laboratories and accreditation bodies is also crucial for a fair and harmonised approach to laboratory assessment across the world.&nbsp;</p><h4><strong>A common language&nbsp;</strong></h4><p>We need a <strong>common language</strong>; clear and unambiguous. We need a common vocabulary to provide consistent definitions of concepts with their associated terms. To this end, several organisations participate in a joint effort to develop and maintain an <strong>international vocabulary of metrology</strong> (VIM) [1], which aims to achieve a unique understanding of concepts related to measurements across all sectors. The VIM is a normative reference in the standards <strong>ISO/IEC 17025, ISO 15189 and ISO/IEC 17043</strong>, and is therefore a key document for all organisations seeking accreditation.&nbsp;</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Eurachem_You_talk_we_understand_The_way_out_of_the_tower_of_Babel_Standards_8d947dbd5f.jpg" alt="Eurachem: You talk, we understand – The way out of the tower of Babel_A common language" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Eurachem_You_talk_we_understand_The_way_out_of_the_tower_of_Babel_Standards_8d947dbd5f.jpg 245w," sizes="100vw" width="1126" height="499"></p><h4><strong>Is this enough?&nbsp;</strong></h4><p>For laboratory staff some problems still stand and need to be addressed:&nbsp;</p><ul><li>Many people are confused about both concepts and terms.&nbsp;</li><li>It may be difficult to understand the “formal” VIM definitions – they are short statements intended to apply to many different measurement sectors.</li><li>Translations into local languages may add to the confusion, e.g. if different terms are used in different sectors for the same VIM concept and the translator overlooks this issue.</li><li>Some substantial changes to terminology have been made in an attempt to accommodate chemical and biological measurements. Some “old” concepts still stand but have new names, e.g. “within laboratory reproducibility” vs. “intermediate precision”.&nbsp;</li></ul><p>To address these issues Eurachem has produced a guide [2] which provides an accessible reference containing simple and in context explanations of terms most relevant to analysts, with additional examples relating those concepts to chemical and biological measurements.&nbsp;</p><h4><strong>Do you understand the meaning of these terms?&nbsp;</strong></h4><p>Are you interested in a <strong>quantity</strong> or a quality? Depending on the answer, will you use a <strong>measurement</strong> <strong>procedure</strong> or an examination? Is method <strong>verification</strong> the same or less demanding than method <strong>validation</strong>? Do you need a <strong>calibration</strong> or just performance verification? Do you have a <strong>measurement standard</strong> in your laboratory? Is <strong>metrological traceability</strong> something you worry about? These are examples of the terms supporting the reliability of any measurement result that need to be clearly understood.&nbsp;</p><h5><strong>Example – Accuracy, trueness, precision: are they synonyms?&nbsp;</strong></h5><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Eurachem_You_talk_we_understand_The_way_out_of_the_tower_of_Babel_accuracy_231e1e005e.jpg" alt="Eurachem: You talk, we understand – The way out of the tower of Babel_Example – Accuracy, trueness, precision" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Eurachem_You_talk_we_understand_The_way_out_of_the_tower_of_Babel_accuracy_231e1e005e.jpg 146w," sizes="100vw" width="754" height="807"></p><ul><li>Closeness between measurement results (relating to the concept of precision)</li><li>Closeness of the average of the measurement results to a reference value (relating to the concept of trueness)&nbsp;</li><li>Closeness of an individual measurement result to the true value (relating to the concept of accuracy)&nbsp;</li></ul><p>The different situations in the figure show the effect of:&nbsp;</p><ol style="list-style-type:lower-latin;"><li>poor precision and trueness (imprecise and biased)&nbsp;</li><li>good precision, poor trueness (precise but biased)&nbsp;</li><li>poor precision, good trueness (imprecise but unbiased)&nbsp;</li><li>good precision and trueness (precise and unbiased)&nbsp;</li></ol><p>Improving both precision and trueness is expected to improve accuracy.&nbsp;</p><h4><strong>Is all this relevant to you?&nbsp;</strong></h4><p>Do you work in a laboratory, either as an analyst, quality manager or director? Are you involved in other activities related to analytical work, such as providing proficiency tests, producing reference materials or accrediting any such activity? Do you teach or study subjects related to measurements? Do you use measurement results or prescribe how to use them? <i><strong>If the answer is yes to any of these questions, the following reference documents are also for you</strong></i>.</p>

You talk, we understand – The way out of the tower of Babel

<p><strong>Visit the LabRulez booth at </strong><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/events/871"><strong>analytica 2026</strong></a><strong> in Munich, 24. - 27. March 2026! You can find us in Hall A1, Booth A1.506. At the booth, you will be able to explore live demonstrations of how the LabRulez portals work and see selected analytical instruments from our pre-owned marketplace section.</strong></p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Lab_Rulez_at_Analytica_2026_Floor_plan_55e1057e03.jpg" alt="LabRulez at Analytica 2026: Hall A1 Floor Plan and Booth Location" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Lab_Rulez_at_Analytica_2026_Floor_plan_55e1057e03.jpg 245w," sizes="100vw" width="1516" height="881"></p><h3><strong>Would you like to learn how the LabRulez portals work?</strong></h3><p>➡︎ <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/"><strong>LabRulezLCMS</strong></a><br>➡︎ <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/"><strong>LabRulezGCMS</strong></a><br>➡︎ <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/"><strong>LabRulezICPMS</strong></a></p><ul><li>A <strong>unique online solution</strong> for <strong>your marketing</strong></li><li>A <strong>targeted audience</strong> from the <strong>analytical chemistry community</strong></li><li><strong>Modern technologies</strong> and a unique concept</li><li><strong>Design optimized for most smart devices</strong> – PC, mobile, and tablet</li><li><strong>Advanced statistical tools</strong> fully available to users</li></ul><h3><strong>Services Offered</strong></h3><h4><strong>News + Company Updates</strong></h4><ul><li>Publish <strong>news related to your instrumentation, applications, services, events, job openings</strong>, and more</li><li><strong>News is shared</strong> both on our <strong>portals</strong> and across our <strong>social media channels</strong></li></ul><h4><strong>Library – All Documents in One Place</strong></h4><ul><li><strong>Applications, posters, presentations, technical articles, brochures, specifications</strong></li><li><strong>Fas</strong>t and <strong>advanced search</strong> capabilities</li><li>Over <strong>32,000 documents</strong> currently available in our database</li></ul><h4><strong>Webinars</strong></h4><ul><li><strong>Upcoming and on-demand webinars</strong> from the field of analytical chemistry</li><li>More than <strong>5,500 webinars</strong> covering chromatography, mass spectrometry, and spectroscopy</li></ul><h4><strong>Careers</strong></h4><ul><li><strong>Targeted job</strong> listings in <strong>analytical chemistry</strong></li><li>Clear filtering by specialization or location</li><li><strong>Increased visibility for job postings</strong></li></ul><h4><strong>Companies</strong></h4><ul><li><strong>Company profile</strong> with key information and contacts</li><li><strong>Integration of all your activities on our portal:</strong> News, Library documents, Webinars, Upcoming Events, Careers, and mentions by partners or customers</li><li><strong>Connection to your Products </strong>listed on LabRulez portals</li></ul><h4><strong>Products and Services</strong></h4><ul><li>Comprehensive <strong>overview of instrumental techniques and services</strong></li><li>Targeting the analytical chemistry community and customers in the growing online environment</li></ul><h4><strong>Marketplace</strong></h4><ul><li><strong>Buying and selling pre-owned analytical equipment</strong></li><li>We purchase analytical instrumentation of all brands and ages</li><li><strong>Sell your equipment through LabRulez</strong></li><li>Request and purchase <strong>complete systems, modules</strong>, or <strong>spare parts</strong> with warranty and service</li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Lab_Rulez_at_analytica_2026_bazar_7edf4a0872.jpg" alt="LabRulez at analytica 2026" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Lab_Rulez_at_analytica_2026_bazar_7edf4a0872.jpg 88w," sizes="100vw" width="1600" height="2844"></p><h3><strong>What Will Be on Display at Our Booth?</strong></h3><p>Come and explore selected spare parts and modules from our marketplace section. These include both new, tested, and pre-owned items.</p><h4><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/bazaar"><strong>LabRulezLCMS Marketplace</strong></a></h4><p><strong>Spare parts for LC/MS:</strong></p><ul><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/bazaar?category=378"><strong>Vacuum turbo pumps for LC/MS</strong></a></li></ul><p><strong>Spare parts for HPLC:</strong></p><ul><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/bazaar?category=397"><strong>Degassers for HPLC/UHPLC</strong></a></li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/bazaar?category=368&amp;search=valve"><strong>Automatic valves for HPLC</strong></a></li><li>HPLC components for Agilent 1100, 1200, and 1260 Infinity II series</li></ul><p><strong>Consumables:</strong></p><ul><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/bazaar?category=377"><strong>HPLC lamps</strong></a></li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/bazaar?category=48"><strong>HPLC columns</strong></a></li></ul><h4><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/bazaar"><strong>LabRulezGCMS Marketplace</strong></a></h4><p><strong>Spare parts for GC/MS:</strong></p><ul><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/bazaar?category=367&amp;search=turbo"><strong>Turbo pumps for GC/MS</strong></a></li></ul><p><strong>Spare parts for GC:</strong></p><ul><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/bazaar?category=366&amp;search=EPC"><strong>EPC modules</strong></a></li></ul><p><strong>Sample injection</strong></p><ul><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/bazaar/432"><strong>Autosampler 7693A for GC</strong></a></li></ul><p><strong>Consumables:</strong></p><ul><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/bazaar?category=7"><strong>GC columns </strong></a>and selected accessories</li></ul>

LabRulez at analytica 2026

<p><strong>Our Library never stops expanding. What are the most recent contributions to LabRulezICPMS Library in the week of 23rd March 2026? Check out new documents from the field of spectroscopy/spectrometry and related techniques!</strong></p><blockquote><p><span style="font-size:20px;">👉 </span><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/library"><span style="font-size:20px;"><strong>SEARCH THE LARGEST REPOSITORY OF DOCUMENTS ABOUT SPECTROSCOPY/SPECTROMETRY RELATED TECHNIQUES</strong></span></a></p></blockquote><blockquote><p><strong>👉 Need info about different analytical techniques?</strong> Peek into <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/library"><strong>LabRulezLCMS</strong></a> or <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library"><strong>LabRulezGCMS</strong></a> libraries.</p></blockquote><p>This week we bring you application notes by <strong>LECO,</strong> <strong>Shimadzu </strong>and <strong>Waters Corporation</strong> and brochure by<strong> Thermo Fisher Scientific!</strong></p><h3><strong>1. LECO: Determination of Nitrogen in Fertilizer</strong></h3><ul><li>Application note</li><li><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/labrulez-bucket-strapi-h3hsga3/CN_FP_928_NITROGEN_FERTILIZERS_203_821_615_4d4b013a08.pdf"><strong>Full PDF for download</strong></a></li></ul><p>Nitrogen is one of the most important elements for plant development and is the macronutrient that is most often found to be deficient in arable soils used for crop production. Nitrogen plays a key role in the formation of enzymes and proteins, which promotes lush, vigorous growth and development in plants that often leads to an increase in the yield from the plant. Fertilizers are utilized to re-introduce nitrogen back into arable soils. Fertilizers can be grouped by their makeup and/or origins into categories including inorganic and/or synthetic (including nitrates, ammonium, and urea) and organic (including compost materials and manures). The accurate and precise determination of nitrogen in all fertilizer types is not only important in the process of blending and preparing the fertilizer material for use, but also will have significant impact on the commercial value and guarantee of the fertilizer.&nbsp;</p><p>The CN928/FP928 is a macro combustion carbon and nitrogen/protein determinator that utilizes a pure oxygen environment in a high-temperature horizontal ceramic combustion furnace designed to handle macro sample mass. A thermoelectric cooler removes moisture from the combustion gases before they are collected in a ballast. The gases equilibrate and mix in the ballast before a representative aliquot (3 cm<sup>3</sup> or 10 cm<sup>3</sup> volume) of the gas is extracted and introduced into a flowing stream of inert gas (helium or argon) for analysis. The aliquot gas is carried to a thermal conductivity cell (TC) for the detection of nitrogen (N<sub>2</sub>).</p><h4><strong>Instrument Model and Configuration&nbsp;</strong></h4><p>Thermal conductivity detectors work by detecting changes in the thermal conductivity of the analyte gas compared to the constant thermal conductivity of the reference/carrier gas. The greater the difference between the thermal conductivity of the carrier gas and the analyte gas, the greater the sensitivity of the detector. The <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/library?mainauthorItems=24&amp;search=CN928"><strong>CN928</strong></a>/<a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/library?mainauthorItems=24&amp;search=FP928"><strong>FP928</strong></a> supports either the use of helium or argon as the instrument's carrier gas. When used as a carrier gas, helium provides the highest sensitivity, and the best performance at the lower limit of the nitrogen range. The thermal conductivity difference between argon and nitrogen is not as great as the thermal conductivity difference between helium and nitrogen, therefore the detector is inherently less sensitive when using argon as a carrier gas.</p><h4><strong>TYPICAL RESULTS&nbsp;</strong></h4><p>Data was generated utilizing a single standard, forced through origin calibration using ~ 0.1 g of NIST 913b Uric Acid (33.23% N). Alternatively, LECO 503-530 LCRM Urea may be used for calibration.</p><h3><strong>2. Shimadzu: Evaluation of Microscopic Foreign Matter in Recycled Plastics Using Dynamic Image Analysis, Infrared Microscopy, and SEM-EDS</strong></h3><ul><li>Application note</li><li><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/labrulez-bucket-strapi-h3hsga3/an_01_00861_en_7485baba21.pdf"><strong>Full PDF for download</strong></a></li></ul><h4><strong>User Benefits</strong></h4><ul><li>&nbsp;It is easy to evaluate the size and quantity of microscopic foreign particles, which are key quality criteria of recycled plastics.</li><li>With the microcell method of DIA, microscopic foreign matter can be detected and counted quickly using a small sample quantity.</li><li>Infrared microscope and SEM-EDS systems provide information about the morphology and composition of microscopic foreign matter that is useful for improving recycling processes.</li></ul><p>One of the quality criteria for recycled plastic flakes and pellets is the content of foreign matter. Quantitatively evaluating the size and quantity of foreign particles contained in flakes and pellets is important for examining foreign matter removal processes intended to improve pellet quality and optimize manufacturing processesfor products made with recycled materials.&nbsp;</p><p>In this article, pellets of virgin and recycled polyethylene terephthalate (hereafter PET) were dissolved in hexafluoro-2-propanol (hereafter HFIP), a solvent for dissolving PET, to prepare suspensions of insoluble microscopic foreign particles. These suspensions were measured with a dynamic particle image analysis (DIA) system (<a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/library?mainauthorItems=1&amp;search=iSpect+DIA-10"><strong>iSpect DIA-10</strong></a>) to evaluate the size and number of insoluble microscopic foreign particles (patent pending). In addition, part of the suspensions were diluted tenfold and filtered through a membrane filter to collect the insoluble microscopic foreign particles on the filter. The morphology and composition of the collected microscopic foreign particles were evaluated using a digital microscope, an infrared microscope system (<a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/library?mainauthorItems=1&amp;search=IRTracer-100"><strong>IRTracer-100</strong></a> and <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/library?mainauthorItems=1&amp;search=AIM-9000"><strong>AIM-9000</strong></a>), and an SEM-EDS system. These evaluations enabled comparison of the sizes, quantities, and types of foreign particles contained in virgin and recycled materials.</p><h4><strong>Conclusion&nbsp;</strong></h4><p>By using an iSpect DIA-10 system to measure suspensions prepared by dissolving two types of PET pellets (virgin and recycled) in HFIP, we obtained particle images of insoluble foreign matter and evaluated size and concentration of particles. That enabled quantitative comparison of particle size and count in microscopic foreign matter contained in virgin and recycled materials.&nbsp;</p><p>In addition, after diluting the pellet suspensions, the insoluble microscopic foreign matter in the diluted suspensions was collected on filters. The morphology and composition of the microscopic foreign matter were evaluated using an infrared microscope and SEM-EDS system. The results indicated that the suspensions contained organic substances, such as cellulose and amide-based compounds, and inorganic substances and metals that contain elements such as C, O, Ca, and Al (suggestive of carbonates and metallic aluminum).&nbsp;</p><p>Thus, the iSpect DIA-10 enables simple quantitative evaluation of the size and number of microscopic foreign particles in PET pellets using only small sample quantities. Furthermore, composition evaluation by infrared microscope and SEM-EDS systems provides useful information for investigating the origin of foreign matter, examining measures to reduce foreign matter, and evaluating impacts on final products. If similarities in size and shape are observed, particle images obtained with iSpect DIA-10 can also potentially be used to estimate particle composition.</p><h3><strong>3. Thermo Fisher Scientific: Ensuring safer and effective pharmaceutical formulations by X-ray diffraction</strong></h3><ul><li>Brochures and specifications</li><li><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/labrulez-bucket-strapi-h3hsga3/PF_41381_xrd_solutions_pharma_9b89684165.pdf"><strong>Full PDF for download</strong></a></li></ul><p>From drug discovery and preformulation studies to the efficient scaling up in the manufacturing process in the plant and finally through QA/QC validation, X-ray diffraction (XRD) is a vital analysis method in the characterization of different physico-chemical properties of the active pharmaceutical ingredient (API). XRD is a gold standard method and required technique in the determination of polymorphic and salt screening, % of crystallinity and stability/reactivity studies of the final API.&nbsp;</p><h5><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/products/2297"><strong>Thermo Scientific™ SolstiX™ XRD Software</strong></a><strong> with Security Suite extends ARL EQUINOX 100 X-ray Diffractometers to 21 CFR Part 11 regulated labs&nbsp;</strong></h5><ul><li>Protect stored electronic data related to quality assurance within manufacturer’s computer systems&nbsp;</li><li>Put controls in place to keep records authentic, incorruptible, and confidential&nbsp;</li><li>Electronic signatures for the user to take responsibility for the electronic data in the system&nbsp;</li><li>Requirements in the data record: date and time of scan, name of the unique signer, and technological controls to ensure security (e.g. passwords)&nbsp;</li></ul><h5><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/products/2143"><strong>Thermo Scientific™ ARL™ EQUINOX 100 X-ray benchtop diffractometer</strong></a><strong> is designed to exceed your analytical needs&nbsp;</strong></h5><ul><li>Ideally suited for rapid screening of various formulations, finger printing or detection of counterfeit products&nbsp;</li><li>Polymorphism and crystallinity determination, crystallite size calculation, quantitative phase analysis, reactivity and stability of materials, etc.&nbsp;</li><li>XRD experiments on standard powders, bulks, tablets, small quantities, etc.&nbsp;</li><li>Real-time full pattern XRD based on our unique PSD detector technology&nbsp;</li><li>X-ray source based on micro-source technology with no external water cooling</li><li>Unique dual-mode capability: reflection and/or transmission&nbsp;</li></ul><h5><strong>Thermo Scientific™ ARL™ EQUINOX 100 XRD for structural analysis&nbsp;</strong></h5><ul><li>Easy-to-use simultaneous full pattern XRD based on unique real time PSD detector technology&nbsp;</li><li>Unique dual-mode capability on a benchtop XRD instrument: reflection and/or transmission mode&nbsp;</li><li>XRD experiments on various samples with sample spinner, capillary stage, sample changer or in controlled environment</li></ul><h5><strong>Top XRD benefits for pharma&nbsp;</strong></h5><ul><li>Structural characterization technique&nbsp;</li><li>Nondestructive technique&nbsp;</li><li>Small amount of sample needed for analysis&nbsp;</li><li>Unique diffraction patterns and quick response&nbsp;</li><li>Analysis on mixtures as well as amorphous content&nbsp;</li><li>Easy determination of induced structural changes</li></ul><h3><strong>4. Waters Corporation: SIMI: A Different Approach to Revealing Dangerous Subvisible Impurities</strong></h3><ul><li>Application note</li><li><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/labrulez-bucket-strapi-h3hsga3/720009094_en_fb955e89ec.pdf"><strong>Full PDF for download</strong></a></li></ul><p>Foreign particulate matter, also known as extrinsic particles, has become a serious threat to patient safety in recent years, with cases linked to severe immunogenic reactions, deaths, and costly recalls.<sup>1</sup> In 2021 alone, Takeda recalled 1.6 million doses of the Moderna COVID-19 mRNA vaccine in Japan after several patient deaths were linked to steel particulates shed from a malfunctioning pump.<sup>2</sup> Over the span of seven years, from 2014–2017, there were more than 110 drug recalls as a result of glass delamination,<sup>3–4</sup> and several more due to remnant crystals,<sup>5</sup> owing to the difficulty of identifying the presence and source of foreign particulate matter. To prevent against such threats, manufacturers require high throughput technologies to better identify foreign particulate matter in real time.</p><h4><strong>Results and Discussion</strong></h4><h5><strong>Shining a Light on Extrinsic Particles with SIMI</strong></h5><p>Side illumination membrane imaging (SIMI) is a proprietary illumination, imaging, and analysis technique exclusively available to <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/products/2190"><strong>Aura instruments</strong></a>. Utilizing the principles of darkfield microscopy,<sup>6</sup> SIMI is conducted on an Aura membrane plate using an oblique illumination source which emits light at an angle parallel to the surface of the plate.&nbsp;</p><p>Compared to backgrounded membrane imaging (BMI), which utilizes brightfield microscopy (epi-illumination) where particles scatter the incident light isotropically (i.e., at all angles), side illumination membrane maging (SIMI) is a technique that is specifically designed to detect light scattering from high refractive index particles, as well as those that protrude out of the plane from the membrane surface. A particle’s average SIMI intensity is measured in a relative scale where the inherent SIMI scattering of the membrane is defined as SIMI = 0. Positive SIMI values indicate particles protruding out of the membrane, as is the case with microplastics, fibers, and other common extrinsic particles, whose average SIMI intensities vary from 0–255. On some occasions, like with metallic particles and absorbing oils, particles will have reduced light refraction relative to the membrane and thus display negative SIMI values, varying from 0 to -122.&nbsp;</p><p>The majority of foreign, extrinsic particles exhibit a high refractive index and are mechanically rigid in structure, causing them to protrude from the membrane surface and scatter side illumination to a high degree, ideal for SIMI analysis. In contrast, biologic particles exhibit the opposite properties—low refractive index and malleable structures, causing them to lie flat with minimal side scatter profiles, which is best analyzed with BMI or fluorescence membrane microscopy (FMM). Utilizing all three microscopy approaches is most ideal to facilitate the determination of all extrinsic (non-biologic) and inherent (biologic) particles in biologic formulations.</p><h4><strong>Conclusion&nbsp;</strong></h4><p>SIMI is a unique approach to providing additional characterization of subvisible particles and is available in all Aura models to help rapidly identify foreign material in biological samples with a high degree of specificity. A key tertiary imaging mode in addition to BMI and FMM, SIMI provides selective, orthogonal morphological information to identify tall and rigid materials, a defining feature of most extrinsic particles (Figure 11). While particle sizing and counting is done via BMI, SIMI provides illumination, imaging, and analysis that can be useful across a variety of biological products to reveal foreign subvisible particles from the earliest to the latest of stages in the bioprocess.</p>

News from LabRulezICPMS Library - Week 13, 2026

Article

Events

Application

Science and research

Eurachem is a European network promoting international traceability of chemical measurements and good analytical practice. It provides expert guidance, supports method validation, uncertainty evaluation, proficiency testing, and facilitates discussion on technical and policy issues in analytical quality.

Eurachem

Everything from the world of analytical chemistry in one place. We connect people in solving their problems. At Labrulez you will find all the necessary information easily, quickly and clearly. Stop searching and start finding.

LabRulez

Separation Science

Mettler-Toledo

Anton Paar

Agilent Technologies

AZoM

Thermo Fisher Scientific

SelectScience

C&EN

<p><strong>E&amp;Ls can enter a drug product during manufacturing, storage, and from the packaging system. The packaging components (those in contact with the drug product) can contain organic and inorganic E&amp;L contaminants present a risk due to their inherent toxicity, while other compounds may adversely affect the efficacy, stability, and shelf-life of the drug.</strong></p><p>We will share an E&amp;L study that shows both the potential for the drug product to become contaminated under extreme conditions (extractables), and the actual contamination that occurs during normal and extended storage (leachables).</p><blockquote><p><strong>Presenter:</strong> L. Craig Jones (ICP-MS Application Scientist, Agilent Technologies, Inc.)</p><p>Craig has been with Agilent for over 15 years as an ICP-MS applications scientist. He has been involved with multiple type of applications for ICP-MS, including environmental, pharmaceutical, semiconductor, geologic, and clinical analyses, to name a few. Previous to Agilent he worked in an environmental lab performing analysis and supervising both the inorganic and organic sections of the laboratory. In his spare time, Craig enjoys volunteering at the local marine science center, mountain biking, hiking, and relaxing at the beach. Craig obtained a Bachelor of Science degree in chemistry from Fort Lewis College in Durango, CO.</p><p><strong>Presenter:</strong> Jenny Nelson, PhD (Application Scientist, Agilent Technologies, Inc.)</p><p>Dr. Jenny Nelson is an Applications Scientist with Agilent Technologies specializing in Inductively Coupled Plasma Mass Spectroscopy (ICP-MS), Inductively Coupled Plasma Optical Emission Spectroscopy (ICP-OES), Microwave Plasma Atomic Emission Spectroscopy (MP-AES). Her broad knowledge of atomic spectroscopy has been applied to both AOAC and ASTM through her serving on expert review panels, chairing committees, and volunteering to develop new methods needed by the industry.</p></blockquote>

Agilent: Determination of Extractable and Leachable Elements Using ICP-MS

Determination of Extractable and Leachable Elements Using ICP-MS

Determination of Extractables and Leachables Using ICP-MS

<header><h5><strong>Understand the Principles of Thermal Energy Storage and How to Characterize Your Materials</strong></h5></header><main><div><div><p><strong>Program</strong></p><ul><li>Discover the basic principles of thermal energy storage and phase change materials (PCMs)</li><li>Insights into thermal analysis techniques</li><li>Typical thermal investigations used to characterize PCMs</li><li>Explore real-world applications using DSC, TGA, TMA, and DMA</li><li>Interactive Q&amp;A</li></ul></div></div><div><div><p>Phase change materials are remarkable substances that absorb and release significant amounts of thermal energy during phase transitions such as solid-to-liquid and liquid-to-solid. Water ice is a typical example. Due to their behavior, PCMs can be used to store excess energy that might otherwise be lost. A practical example is in buildings, where PCMs store heat generated from solar panels, which is released when the temperature drops.</p><p>As energy storage systems continue to evolve, understanding the thermal behavior of PCMs is critical. The four main techniques of&nbsp;<a target="_blank" rel="noopener noreferrer" href="https://www.mt.com/cz/cs/home/products/Laboratory_Analytics_Browse/TA_Family_Browse/ta-instruments/thermal-analysis-system-DSC-5-plus.html">DSC</a>,&nbsp;<a target="_blank" rel="noopener noreferrer" href="https://www.mt.com/cz/cs/home/products/Laboratory_Analytics_Browse/TA_Family_Browse/ta-instruments.html?filter%5btechnique%5d=Thermogravimetry%20(TGA)">TGA</a>,&nbsp;<a target="_blank" rel="noopener noreferrer" href="https://www.mt.com/cz/cs/home/products/Laboratory_Analytics_Browse/TA_Family_Browse/ta-instruments/thermal-analysis-system-TMA-SDTA-2-plus.html">TMA</a>, and&nbsp;<a target="_blank" rel="noopener noreferrer" href="https://www.mt.com/cz/cs/home/products/Laboratory_Analytics_Browse/TA_Family_Browse/ta-instruments.html?filter%5btechnique%5d=Dynamic%20Mechanical%20Analysis%20(DMA)">DMA</a>&nbsp;are particularly effective for investigating both the PCM itself and the suitability of the encapsulation materials.</p><p>Join our upcoming webinar to explore effective techniques and practical applications that will help you characterize your own PCMs!</p></div></div><div><div><div><h5><strong>Typical Uses of Phase Change Materials</strong></h5><p>Beyond thermal management of buildings, PCMs play a crucial role in various sectors where temperature regulation or energy storage is key. This can range from storing excess thermal energy from solar power plants, to the transportation or temporary storage of fresh food, medical samples, and pharmaceuticals. PCMs are also found in specialized textiles, automotive thermal management, and hot-cold healthcare therapies.</p><p>Our live webinar takes a deep dive into the principles of thermal energy storage. We will share the best thermal analysis techniques for studying PCMs and you will also find real-life application examples, which you can apply to your own materials.</p><p>We conclude with a Q&amp;A session so don’t forget to prepare your questions!</p><ul><li><span style="padding-right:0px;" id="webinar-session-1"><strong>11. 12. 2025 8:00,&nbsp; English&nbsp;</strong></span><span id="webinar-session-2"><strong><svg width="16" height="16" viewBox="0 0 16 16" fill="none" xmlns="http://www.w3.org/2000/svg"></svg></strong></span></li><li><span id="webinar-session-2"><strong>11. 12. 2025 16:00,&nbsp; English&nbsp;</strong></span></li></ul></div><div><div data-advanced-option="false" data-has-preview-image="false" data-video-id="" data-component-id="2110920040"><div style="max-width:1px;width:100%;" id="mediaContainerWrapper_2110920040"><div style="height:1px;width:1px;" data-external-url="" id="mediaContainer_2110920040" data-advanced-option="false" data-width="1" data-height="1" data-video-id="">&nbsp;</div></div></div></div></div></div></main><div><div><div data-advanced-option="false" data-has-preview-image="false" data-video-id="" data-component-id="2110920040"><blockquote><div><strong>Presenter: </strong>Dr. Andreas Bach</div><div><p>Andreas was awarded a PhD in Chemistry from the University of Bern in Switzerland and completed a postdoc at the University of Wisconsin-Madison Department of Chemistry, USA. In 2002, he accepted a position as a senior scientist and lecturer in physical organic chemistry in the Department of Chemistry and Applied Biosciences at ETH Zurich. In 2018, he joined METTLER TOLEDO as an application specialist for Thermal Analysis. In his current position, he expertly uses, teaches and supports DSC, TGA, TMA, and DMA instruments at the METTLER TOLEDO head office in Switzerland.</p></div></blockquote></div></div></div>

Mettler Toledo: Thermal Analysis of Phase Change Materials 

Thermal Analysis of Phase Change Materials 

Join our upcoming webinar to explore effective techniques and practical applications that will help you characterize your own PCMs!

<div><div container-id="cq-colctrl-lt0" comp-id="A1"><div><p><strong>Working with atomic spectroscopy techniques can present numerous challenges, including matrix effects, interferences, drift, carryover, tight timelines, and compliance demands, to name a few.</strong></p><p>Bring your questions on ICP-MS, ICP-OES, and AAS to our upcoming Q&amp;A session. Rob Thomas, principal scientist of Scientific Solutions, will address the decisions that shape trace-element analysis—how to choose an approach, set up workflows, and keep data defensible. We’ll let your questions guide the conversation.</p><h5><strong>By attending this webinar, you will learn:</strong></h5><ul><li>Clear ways to compare ICP-MS, ICP-OES, and AAS for your needs</li><li>Practical guidance on setup, workflow design, and data quality</li><li>Tips to avoid common pitfalls and streamline routine work</li><li>Resources to help you apply best practices in your lab</li></ul><p>With the opportunity to ask specific questions, you’ll walk away with practical insights to help with your unique application.</p><blockquote><p><strong>Presenter: </strong>Robert Thomas (Asst. Adjunct Professor, University of North Dakota)</p><p>Robert (Rob) Thomas is the principal scientist of Scientific Solutions, a consulting company that serves the educational needs of the trace ele­ment user community. He has worked in the field of atomic and mass spectroscopy for over 50 years, including 24 years for a manufacturer of atomic spectroscopic instrumentation. Rob is the editor and frequent contributor of the Atomic Perspectives (AP) column in Spectroscopy Magazine and also serves on the editorial advisory board of Technology Networks. In addition, he recently accepted the position of Assistant Adjunct Professor at the University of North Dakota. Rob also leads the plasma spectrochemistry, heavy metals task force on the ACS Committee on Reagent Chemicals.</p><p>Rob has written over 130 technical publications, including a 15-part tutorial series on ICP-MS, and authored 6 textbooks on the fundamental principles and applications of ICP-MS. His most recent book is entitled, Practical Guide to ICP-MS and Other Atomic Spectroscopy Techniques: A Tutorial for Beginners. Rob has an advanced degree in analytical chemistry from the University of Wales, UK, and is also a Fellow of the Royal Society of Chemistry (FRSC) and a Chartered Chemist (CChem).&nbsp;</p></blockquote></div></div></div>

SeparationScience: Expert Answers: Spectroscopy Tips and Troubleshooting

Expert Answers: Spectroscopy Tips and Troubleshooting

Explore spectroscopy techniques, challenges, and solutions in our upcoming webinar featuring expert insights on ICP-MS and more.

<div><div id="inner_content_body_text" data-content-id="394785"><p><strong>In response to growing environmental concerns and the urgent need for sustainable practices, the upcycling of post-consumer and reprocessed plastics has become a critical focus. This webinar will delve into the upcycling of reprocessed polypropylene (rPP) through reactive extrusion, emphasizing the use of a compatibilizer and the optimization of key process variables.</strong></p><h4><strong>Key Topics Covered:</strong></h4><ul><li>Optimization of Extrusion Parameters: Learn how factorial design of experiment techniques can be utilized to assess and optimize important extrusion parameters.</li><li>Rheological Testing: Discover how rheological measurements can evaluate polymer structure, processability, and performance.</li><li>FTIR Microscopy Mapping: Explore how FTIR microscopy mapping aids in understanding the structure of polymer blends.</li><li>Compatibilizer Benefits: Gain insights into how the addition of a compatibilizer can improve the mechanical properties of immiscible polymer blends.&nbsp;</li></ul><h4><strong>Attend This Webinar to:</strong></h4><ul><li>Enhance your knowledge of polymer upcycling and reactive extrusion.</li><li>Learn about cutting-edge analytical techniques for evaluating key process parameters.</li><li>Discover how to optimize polymer processing for improved sustainability and performance.</li></ul><h4><strong>Ideal For Those Who:</strong></h4><ul><li>Explore advanced methods for polymer recycling.</li><li>Develop eco-friendly processing technologies.</li><li>Optimize workflows for circular material use.</li><li>Apply cutting-edge techniques for polymer analysis.</li><li>Implement scalable, sustainable recycling solutions.</li><li>Want to gain insight into next-generation polymer recovery.</li></ul><blockquote><p><strong>Presenter:</strong> Lucivan Barros, Ph.D., Senior Applications Scientist, Thermo Fisher Scientific</p><p>Lucivan Barros is a Senior Applications Scientist at Thermo Fisher Scientific, specializing in extrusion and rheology applications. He earned his Ph.D. in Macromolecular Science from Case Western Reserve University. With expertise in polymer processing, materials development, and structure–property relationships, he is dedicated to advancing sustainable materials and supporting innovation in polymer processing and characterization.</p><p><strong>Presenter: </strong>Ron Rubinovitz, Ph.D., Senior Applications Scientist, Thermo Fisher Scientific</p><p>Ron Rubinovitz, Ph.D. is a Senior Applications Scientist with 14 years of experience at Thermo Fisher Scientific working with FT-IR applications including FT-IR microscopy, FT-Raman spectroscopy and chemometrics. &nbsp;Ron obtained his Ph.D. in physical chemistry at the University of Pennsylvania utilizing FTIR and continues to use the benefits of the FTIR techniques in numerous applications.</p></blockquote></div></div>

Thermo Fisher Scientific: Polymer Upcycling via Reactive Extrusion: FTIR Microscopy Insights into Blend Compatibilization

Polymer Upcycling via Reactive Extrusion: FTIR Microscopy Insights into Blend Compatibilization

Join Thermo to explore reactive extrusion, FTIR mapping, and compatibilizer effects for efficient, sustainable polymer upcycling and improved blend quality.

Polymer Upcycling: FTIR Microscopy Insights

<p><strong>Accurate measurement of protein as well as excipient concentration is essential in downstream biopharmaceutical manufacturing and process control, spanning from post-purification stages to final preparation for fill and finish.</strong></p><p>Join Dr. Janam Pandya and Patrick Brown as they explore how UV-Vis and Raman spectroscopy work together to deliver a complete picture of bioprocess performance. Learn how rapid, at-line UV-Vis analysis provides precise quantification of highly concentrated protein samples, while complementary, in-line Raman spectroscopy continuously monitors protein concentration and excipients in real time.</p><p>By integrating these two optical techniques, scientists can connect fast at-line confirmation with continuous in-line insight, enabling data-driven decisions that enhance process understanding, control, and product quality.</p><h4><strong>Key learning objectives:</strong></h4><ul><li>Understand how UV-Vis and Raman spectroscopy complement one another across at-line and in-line workflows.</li><li>Learn how a new at-line UV-Vis technology enables accurate measurement of highly concentrated protein samples.</li><li>Discover the strengths of process Raman spectroscopy in quantifying protein concentration and excipients in complex matrices.</li><li>Explore how process Raman spectroscopy can be applied for in-line analysis to support process decision-making.</li></ul><h4><strong>Who should attend?</strong></h4><ul><li>Scientists developing standard operating procedures (SOPs) and improving manufacturing processes, including upstream/downstream, MSAT, and PAT roles.</li><li>R&amp;D and technical experts exploring new technologies including lab managers, QA/QC, professors, engineers, and purchasing agents.</li></ul><h4><strong>Certificate of attendance</strong></h4><ul><li>If you attend the live webinar, you will automatically receive a certificate of attendance, including a learning outcomes summary, for continuing education purposes.</li><li>If you view the on-demand webinar, you can request a certificate of attendance by emailing editor@selectscience.net.</li></ul><blockquote><p><strong>Presenter:</strong> Dr. Janam Pandya (Product Manager, Measurement Control and Sample Identification, Thermo Fisher Scientific)</p><p>Dr. Janam Pandya is a scientist and spectroscopist with 10 years of academic and industry experience. Dr. Pandya obtained his Ph.D. in food science from the University of Massachusetts Amherst; there his research focused on developing novel analytical methods utilizing cutting-edge Raman spectroscopic techniques. Since 2022, he has worked for Thermo Fisher Scientific as an application scientist, advancing the application of Raman Spectroscopy for real-time process measurements. This includes his current focus on implementing process Raman spectroscopy as a PAT tool in the clean-energy sector, among other industries.</p><p><strong>Presenter:</strong> Patrick Brown (Senior Product Manger, Thermo Fisher Scientific)</p><p>Patrick Brown graduated with a masters in Biomedical Science from the Pennsylvania State University and an MBA from University of Delaware. He now leads the UV-Vis Product Management team for Thermo Fisher Scientific, where he works with his team to collect user feedback, and then integrate this feedback into software and hardware updates.</p><p><strong>Moderator: </strong>Olivia Long (Editorial Team, SelectScience)</p></blockquote>

SelectScience: Connecting at-line UV-Vis with in-line process Raman for real-time protein and excipient monitoring

Connecting at-line UV-Vis with in-line process Raman for real-time protein and excipient monitoring

Join us to explore how UV-Vis and Raman spectroscopy work together to deliver a complete picture of bioprocess performance. 

Connecting at-line UV-Vis with in-line process Raman

<div><div id="inner_content_body_text" data-content-id="394785"><p><strong>Carbon Capture, Utilization, and Storage (CCUS) is vital to reaching global net-zero targets. Monitoring impurities such as sulfur compounds, oxides of nitrogen, oxygen, and water is critical to maintaining pipeline integrity, safety, and environmental compliance.</strong></p><p>Join us to explore how advanced gas analysis technologies - Fourier Transform Infrared (FTIR) spectroscopy and mass spectrometry - provide real-time insight into CO₂ purity and process performance. We’ll also discuss how these tools enable efficient production of electro-fuels (e-fuels), where captured CO₂ and renewable hydrogen are converted into sustainable, “drop-in” alternatives to fossil fuels.</p><p><strong>Join the free webinar with certification of attendance now.</strong></p><h5><strong>Attend This Webinar to:</strong></h5><ul><li>Understand the critical role of monitoring impurities to maintain pipeline integrity and ensure safe operation.</li><li>Discover how <strong>Fourier Transform Infrared (FTIR) spectroscopy </strong>enables precise, online monitoring of CO₂ purity and impurity profiles in CCUS pipelines.</li><li>Learn how <strong>FTIR's real-time</strong>, multi-component analysis ensures that captured CO₂ meets specifications required for safe transport and storage - whether for sequestration or utilization.</li><li>Explore how captured CO₂ is combined with green hydrogen to produce synthesis gas, a feedstock for manufacturing e-fuels - a class of sustainable, drop-in fuels designed to replace fossil-derived energy sources.</li><li>Learn about mass spectrometry as a proven solution for demanding environments, offering fast cycle times for high-throughput operations, versatile analytical methods for complex gas mixtures, and high reliability with low cost of ownership.</li></ul><h5><strong>Ideal For:</strong></h5><ul><li>Individuals in the carbon capture value chain in the following disciplines:<ul><li>Academia: colleges &amp; universities; research institutes</li><li>CCUS technology providers</li><li>Food &amp; Beverage packagers</li><li>Government R&amp;D labs, regulatory agencies</li><li>Industrial manufacturing such as cement, chemicals, iron &amp; steel, oil &amp; gas</li><li>Pipeline owners</li><li>Power plants, electric utilities</li><li>Specialty gas companies</li><li>Waste facilities, incinerators</li></ul></li></ul><blockquote><p><strong>Presenter:</strong> Samuel Evans, Senior Sales Development Manager, Thermo Fisher Scientific</p><p>Samuel Evans is a highly accomplished Senior Sales Development Manager at Thermo Fisher Scientific. He holds a PhD in Chemistry, specializing in heterogenous catalysis, which has made him an authority in the field of gas analysis. Samuel's primary focus lies in engaging with customers within the clean energy sector across EMEA and North America. Leveraging his technical expertise, he tailors solutions to meet the unique requirements of each customer in this rapidly evolving industry.&nbsp;</p><p><strong>Presenter: </strong>Daniel Merriman, Senior Advisor, Process Analyzers, Thermo Fisher Scientific</p><p>Daniel Merriman has worked in the field of process analytics since joining the former VG Instruments business in 1988 now a part of Thermo Fisher Scientific, holding many positions in technical, sales and marketing – he is now supporting the strategic marketing group within the Environmental and Process Monitoring business of Thermo Fisher Scientific.</p></blockquote></div></div>

Thermo Fisher Scientific: Achieving Net-Zero: Precision Monitoring in CCUS and Downstream Chemicals

Achieving Net-Zero: Precision Monitoring in CCUS and Downstream Chemicals

Learn how FTIR and MS enable accurate CO₂ impurity monitoring for CCUS and e-fuel production, ensuring pipeline integrity.

Precision Monitoring in CCUS and Downstream Chemicals

<p><strong>Product mix-ups don’t announce themselves, but their consequences do. Whether it’s a misidentified raw material, a wrong line transfer, or a product transmix during pipeline transport, these errors can trigger scrapped batches, costly reprocessing, unplanned downtime, hazardous reactions, and serious safety risks. Traditional lab testing often catches these issues too late, after the damage is done.</strong></p><p>In this mini course, experts from HF Sinclair and Metrohm USA will show how inline Raman spectroscopy reduces product identification time from minutes to seconds, delivering measurable ROI and protecting product integrity. Throughout the presentation, you’ll be able to submit your questions, which will be answered during the live Q&amp;A.</p><p>All participants will have the opportunity to receive a certificate of participation. Join us to gain practical strategies and real-world insights. Register today and take the first step toward eliminating costly mix-ups for good.</p><h4><strong>Key Learning Objectives:</strong></h4><ul><li><strong>Understand the hidden risks of product mix-ups:</strong> Learn how errors during unloading, manufacturing, or transport—such as misidentified materials or wrong line transfers—can lead to safety incidents, quality failures, and costly downtime.</li><li><strong>Discover the limitations of traditional lab testing: </strong>See why lab-based methods often catch problems too late, and how inline Raman spectroscopy enables faster, more proactive detection—before consequences escalate.</li><li><strong>Identify where inline Raman fits in your operations:</strong> Whether you're in chemicals, pharma, energy, or manufacturing, learn how this technology supports product integrity, safety compliance, and cost control across your process streams.</li></ul><h4><strong>Who Should Attend:</strong></h4><ul><li><strong>Production and operations leaders</strong> – including Production Managers, Plant Managers and Operational Managers</li><li><strong>Technical and quality experts </strong>– such as Process Engineers, Quality Control Specialists and Automation &amp; Control Engineers</li><li><strong>Safety and compliance professionals</strong> – including EHS Managers, Safety Officers and Compliance Specialists</li><li><strong>Strategic decision-makers</strong> – such as Project Leads and Technical Stakeholders</li></ul><blockquote><p><strong>Presenter: </strong>Kyle Rasmussen (Quality Assurance Lead, HFSinclair Midstream)</p><p><strong>Presenter:&nbsp;</strong>Teresa Alleman (Product Quality, HFSinclair)</p><p><strong>Presenter:&nbsp;</strong>Elena Hagemann (Product Manager, Process Spectroscopy, Metrohm USA)</p><p><strong>Presenter:&nbsp;</strong>Alexandra Taylor (Contributing Editor, C&amp;EN Media Group)</p></blockquote>

Metrohm: Inline Raman: Avoid the Million-Dollar Product Mix-Up

Inline Raman: Avoid the Million-Dollar Product Mix-Up

Discover how inline Raman spectroscopy prevents product mix-ups, improves safety, and cuts costs with rapid material identification

<p><strong>Dr. Susan Bird, of Thermo Fisher Scientific, will discuss how innovative approaches in metabolomics — including SQUAD (Simultaneous Quantitation and Discovery), exposomics, and alternative fragmentation techniques — are advancing the identification and quantification of small molecules. These strategies enable greater precision and depth in small molecule research, transforming how scientists study metabolites and lipids to better understand metabolism across a wide range of scientific fields.</strong></p><p>In the second half of the presentation, Dr. Melanie Bailey from King’s College London will showcase how the SIESMIC Facility is pioneering the integration of capillary sampling with LC-MS and LA-ICP-MS to achieve sub-cellular proteomics and metals analysis. Her presentation will highlight how this innovative workflow provides new insights into cellular composition and molecular interactions at unprecedented spatial resolution.</p><h5><strong>Key learning points</strong></h5><ul><li><strong>Discover </strong>how Thermo Fisher Scientific’s innovative metabolomics research techniques are advancing the identification and quantification of small molecules, delivering greater precision and depth in analytical research.</li><li><strong>Gain insight</strong> into King’s College London’s SIESMIC Facility and how it integrates capillary sampling with LC-MS to support single and sub-cellular “omics” investigations.</li><li><strong>Examine</strong> the latest LC-MS methodologies enabling higher detection of metabolites and lipids at the single-cell level.</li><li><strong>Understand </strong>emerging theories on metabolic cross-talk between Mycobacterium tuberculosis and host cells—and how these interactions may explain why certain cells become infected while others resist.</li><li><strong>See</strong> how advanced techniques at the SIESMIC Facility combine capillary sampling with LC-MS and LA-ICP-MS to achieve sub-cellular proteomics and metals analysis.</li></ul><h5><strong>Who should attend</strong></h5><ul><li><strong>Metabolomics &amp; Lipidomics Scientists:</strong> Researchers quantifying small molecules or lipids who require enhanced sensitivity, robustness, and reproducibility in targeted or untargeted assays.</li><li><strong>LC–MS Method Developers &amp; Analytical Chemists: </strong>Professionals focused on optimizing separations and acquisition strategies (e.g., full-scan + MS/MS, PRM/DIA) for improved quantitation.</li><li><strong>Data Analysts in Life Sciences: </strong>Teams responsible for managing large metabolomics datasets, applying quality control and normalization, and producing decision-ready insights.</li></ul><blockquote><p><strong>Presenter: </strong>Melanie Bailey, PhD (Professor, Kings College, London)</p><p>Melanie Bailey's research group focus on the development of analytical techniques that can be used to probe biomarkers in cells, tissues and biofluids. She is Director of the BBSRC SEISMIC facility for single and sub-cellular omics, an open resource for bioscientists exploit new capability in single and sub-cellular live cell omics, using capillary sampling. She is a member of the UK National Ion Beam Centre management commitee (EPSRC) and is leading the development of multimodal imaging of elemental and molecular markers, through a novel system using MeV and keV energy ion beams. Her group also have expertise in non-invasive sampling via fingerprints, sebum and saliva, and the development of tools for prognostic and diagnostic markers.</p><p>Prof Bailey is an active member of the Analytical Chemistry Trust Fund, which provides seed funding for analytical scientists. She is passionate about communicating science to the public and recently obtained a Guiness World Record for fastest marathon dressed as a cell to raise money and awareness for analytical science. She is Editor in Chief of the RSC's longest running journal, The Analyst.</p><p><strong>Presenter: </strong>Susan Bird, PhD (Metabolomics Vertical Marketing Manager, Thermo Fisher Scientific)</p><p>As Sr. Manager, Susan is responsible for leading the Metabolomics vertical marketing strategy and leads both the scientific applications and vertical marketing programs. This includes initiatives to expand and strengthen strategic relationships and guide product development to meet the emerging needs of our Metabolomics customers.</p><p>Prior to this role, Susan worked in commercial as an instrument sales rep in the Boston and Cambridge area. Prior to joining Thermo Fisher, she trained as a post-doc and Instructor of medicine at Brigham and Women’s Hospital and Harvard Medical School where she developed non-targeted and targeted lipid profiling methods, applied to epidemiology cohorts.</p><p>This work used primarily LC-MS with Orbitrap detection and provided key contributions to the emerging field of lipidomics.</p></blockquote>

Thermo Fisher Scientific: Innovative metabolomics & lipidomics solutions and single cell & subcellular research spotlight

Innovative metabolomics & lipidomics solutions and single cell & subcellular research spotlight

Join us for an insightful session exploring cutting-edge developments in metabolomics and molecular analysis.

Metabolomics & lipidomics solutions & single cell

<div><div id="inner_content_body_text" data-content-id="394785"><h4><strong>Thermal transitions. Molecular mobility. Crosslinking dynamics.</strong></h4><p><strong>Differential Scanning Calorimetry (DSC) is a cornerstone technique in polymer analysis — providing quantitative insight into enthalpic changes associated with physical and chemical transitions. In this webinar, we deep-dive into the interpretation of DSC data across a range of polymer systems, exploring how thermal events reflect microstructural and phase-related behavior.</strong></p><h5><strong>Key topics include:</strong></h5><ul><li><strong>Glass transition (Tg):</strong> Interpreting changes in heat capacity and their link to molecular mobility and amorphous content</li><li><strong>Melting and crystallization: </strong>Determination of melting point, enthalpy, crystallinity and crystallization behavior</li><li><strong>Curing kinetics: </strong>Monitoring exothermic reactions in thermosets and composite matrices</li><li><strong>Oxidative stability and thermal degradation:</strong> Insights into OOT and OIT</li><li><strong>Method development strategies:</strong> Optimal sample preparation, pan selection, and heating/cooling protocols for polymer-specific workflows</li></ul><p>Real-world application examples will demonstrate how DSC is used in polymer formulation, quality assurance, and regulatory testing (e.g., ASTM D3418, ISO 11357).</p><blockquote><p><strong>Presenter:</strong> Jiří Kislinger</p><p>Jiří Kislinger is a Product Manager at Anton Paar, specializing in advanced analytical instrumentation. He holds a PhD in Physical Chemistry from Brno University of Technology, where he focused on material science and thermodynamics. With his strong academic background and years of industry experience, Jiří is instrumental in shaping innovative product solutions. We're excited to welcome him as our featured speaker for this webinar.</p></blockquote></div></div>

Anton Paar: Heated Stories: What DSC Reveals About Polymers

Heated Stories: What DSC Reveals About Polymers

In this webinar, we deep-dive into the interpretation of DSC data across a range of polymer systems

<div><div container-id="cq-colctrl-lt0" comp-id="A1"><div><p><strong>This session will delve into model training, method validation, tips and tricks to improve or ensure method robustness and custom methods.</strong></p><p>Don't miss this opportunity to enhance your understanding and skills!</p><blockquote><p>First session: <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/webinar/5748"><strong>Watch on-demand here</strong></a></p></blockquote><h5><strong>In this webinar, you'll learn:</strong></h5><ul><li>How to build method training&nbsp;</li><li>Method validation</li><li>How to ensure model robustness on the Vaya?</li><li>What is a custom method on Vaya?</li></ul><p>This webinar is beneficial for all Vaya users or any pharma/biopharma customers interested to know more on through-packaging raw materials identification.</p><blockquote><p><strong>Presenter:</strong> Chris Welsby (Raman ID Product Line Manager, Agilent Technologies)</p><p>Chris is a PhD chemist, graduating from Cardiff University in 2001 having studied heterogenous catalysis, now focusing on molecular spectroscopy products intended for the pharma industry, namely Spatially Offset Raman Spectroscopy (SORS) through barrier technology, to enable verification of raw material ID through packaging in the warehouse environment. Chris has worked as part of the marketing team on Spatially Offset Raman applications since 2016, firstly as an Applications Scientist and latterly as a Marketing Product Manager of the Vaya handheld for raw material ID.</p></blockquote></div></div></div>

Agilent Technologies: Tip and Tricks – How to Best Use the Handheld Raman Vaya