<p><strong>Jiří Nováček, a researcher and the deputy director for research infrastructure at CEITEC Masaryk University, shares insights into his journey with Brnoregion Microscopy. Sparked by a conversation with Jan Neuman, Nováček saw the potential of integrating Atomic Force Microscopy (AFM) into life-science electron microscopy. Today, he plays an active role in the community, collaborating with colleagues to enhance educational initiatives.&nbsp;</strong></p><h4><strong>How did you become involved with Brnoregion Microscopy?</strong></h4><p>My involvement with Brnoregion Microscopy began through my interaction with <a target="_blank" rel="noopener noreferrer" href="https://brnoregion.com/en/news/people-of-brnoregion-microscopy-jan-neuman-nenovis">Jan Neuman</a>. We were discussing the potential applications of their integrated Atomic Force Microscopy (AFM) module in the field of life-science electron microscopy. I was immediately intrigued by the idea of forming a microscopy community and saw great potential in it. Jan's vision of fostering stronger local connections among colleagues with complementary expertise resonated with me. This alignment of interests and the shared goal of advancing our understanding and capabilities in microscopy made me eager to join and contribute to the community.&nbsp;</p><h4><strong>What role do you play in the community?</strong></h4><p>Currently, I am an active member of the Community working group within Brnoregion Microscopy. In this role, I collaborate closely with Tomáš Vystavěl from Thermo Fischer Scientific on various educational initiatives. Our focus is on enhancing the educational aspects of the Microscopy community, looking for opportunities for deepening the knowledge and skills in the area of microscopy in our region. It's a rewarding experience to be part of a team that is dedicated to fostering learning and innovation in this field.&nbsp;</p><h4><strong>What benefits does it bring to you?</strong></h4><p>Being part of the Microscopy community has been incredibly enriching for me. It provides a platform for continuous learning and exposure to the latest advancements in microscopy technology and techniques. Working together stimulates new ideas and approaches, which are key to our ongoing development. Additionally, it offers the opportunity to network with experts and peers, opening doors to potential collaborations and projects. That’s how it works in our local innovation ecosystem… &nbsp;</p><h4><strong>Do you have any message for the community?</strong></h4><p>Whether you're already involved or just curious, join the upcoming <a target="_blank" rel="noopener noreferrer" href="https://brnoregion.com/en/events/120-seconds-meet-brnoregion-microscopy-24-11">120 seconds: Meet Brnoregion Microscopy</a> event. It's a fantastic opportunity to see first-hand how the Microscopy community can benefit you. These events are designed to showcase the practical applications of microscopy and the innovative work being done by our members.&nbsp;</p>

People of Brnoregion Microscopy: Jiří Nováček (CEITEC MUNI)

<p><strong>In the week from January 20, the following webinars await you in the field of atomic and molecular spectroscopy and spectrometry</strong></p><blockquote><p><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/webinars"><strong>👉 DETAILS AND REGISTRATION IN THE WEBINARS SECTION</strong></a></p><p><strong>👉 Search and filter in the largest global database</strong> with over <strong>4 000 GC, LC, MS and spectroscopy webinars</strong>.</p></blockquote><h5><strong>1. Anton Paar: Fundamentals of Scratch</strong></h5><div><div><ul><li><div>Tu, 21.1.2025 20:00 CET</div></li><li><div><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/webinar/4449">Registration</a></div></li></ul></div><p>This webinar provides a thorough introduction to the theory and practice of instrumented scratch testing, a critical method for evaluating the mechanical properties of materials under stress.</p></div><h5><strong>2.&nbsp;Mettler-Toledo: Advanced Inspection of Canned Goods with X-ray Inspection</strong></h5><div><div><ul><li><div>We, 22.1.2025 09:00 CET</div></li><li><div><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/webinar/4658">Registration</a></div></li></ul></div><p>Join our webinar to discover the wide range of benefits that x-ray inspection offers canned applications - including advanced detection capabilities and integrity and completeness checks.</p></div><h5><strong>3.&nbsp;Bruker: Nanoscale Chemical Characterization of Semiconductor Materials and Devices using Photothermal AFM-IR</strong></h5><div><div><ul><li><div>We, 22.1.2025 17:00 CET</div></li><li><div><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/webinar/4681">Registration</a></div></li></ul></div><p>In this webinar, Bruker nanoscale IR spectroscopy experts show how photothermal AFM-IR can identify the local chemistry of defects.</p></div><h5><strong>4.&nbsp;Agilent Technologies: Using LDIR for Advanced Microplastics Characterization</strong></h5><div><div><ul><li><div>Th, 23.1.2025 09:00 CET</div></li><li><div><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/webinar/4683">Registration</a></div></li></ul></div><p>This session will highlight the advanced features of LDIR technology and its critical applications in analyzing microplastics within various matrices.</p></div><h5><strong>5.&nbsp;LECO: Optimization of Combustion Methods for Determination of Low-Level Nitrogen-Protein in Food</strong></h5><div><div><ul><li><div>Th, 23.1.2025 16:00 CET</div></li><li><div><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/webinar/4686">Registration</a></div></li></ul></div><p>In this webinar, Lloyd Allen, Ph.D., LECO's Director of the Technical Services Laboratory, will share practical insights on overcoming challenges using advanced combustion instruments.</p></div><h5><strong>6.&nbsp;Agilent Technologies: Different Cones / Nebulizers / Sample Introduction Systems .. Where and When to Use them</strong></h5><div><div><ul><li><div>Th, 23.1.2025 20:00 CET</div></li><li><div><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/webinar/4546">Registration</a></div></li></ul></div><p>Different Cones / Nebulizers / Sample Introduction Systems .. Where and When to Use them</p></div>

Webinars LabRulezICPMS Week 4/2025

<p><strong>The goal of this study is to advance molecular epidemiology by integrating and analyzing large-scale population data from two complementary platforms: quantitative NMR spectroscopy for 209 lipoprotein measures and LC-MS/MS for 809 lipid classes and species. Together, these datasets encompass 1018 molecular measures across 7830 participants from two population cohorts. The study aims to elucidate the molecular and compositional relationships within the circulatory lipid transport system and their connections to physiological and clinical characteristics.</strong></p><p>Through cluster analyses and unsupervised neural network techniques (self-organizing maps), the study identifies inherent links between deep molecular data and population health traits, including cardiometabolic risk factors such as lipoprotein lipids, apolipoprotein B, ceramides, and oxidized lipids. Notable findings include the consistent cardiometabolic risk associations of triglyceride species across the lipoprotein cascade and the intricate metabolic profiles of cholesteryl ester species, which vary in their risk implications. This work highlights the unprecedented detail and compatibility of combined omics methodologies, paving the way for comprehensive molecular insights and new opportunities in large-scale population health studies.</p><blockquote><h4><strong>The original article</strong></h4><h4><a target="_blank" rel="noopener noreferrer" href="https://pubs.acs.org/doi/10.1021/acs.analchem.4c03229"><strong>Personalized Profiling of Lipoprotein and Lipid Metabolism Based on 1018 Measures from Combined Quantitative NMR and LC-MS/MS Platforms</strong></a></h4><p>Siyu Zhao, Corey Giles, Kevin Huynh, Johannes Kettunen, Marjo-Riitta Järvelin, Mika Kähönen, Jorma Viikari, Terho Lehtimäki, Olli T. Raitakari, Peter J. Meikle, Ville-Petteri Mäkinen, Mika Ala-Korpela</p><p>Analytical Chemistry, Vol 96/Issue 52</p><p><a target="_blank" rel="noopener noreferrer" href="https://pubs.acs.org/doi/10.1021/acs.analchem.4c03229">https://doi.org/10.1021/acs.analchem.4c03229</a></p><h6>licensed under <a target="_blank" rel="noopener noreferrer" href="https://creativecommons.org/licenses/by/4.0/"><strong>CC-BY 4.0</strong></a></h6></blockquote><p>&nbsp;</p><p class="cke-user_style-important"><strong>Selected sections from the article follow. Formats and hyperlinks were adapted from the original.</strong></p><h3><strong>Abstract</strong></h3><p>Applications of advanced omics methodologies are increasingly popular in biomedicine. However, large-scale studies aiming at clinical translation are typically siloed to single technologies. Here, we present the first comprehensive large-scale population data combining 209 lipoprotein measures from a quantitative NMR spectroscopy platform and 809 lipid classes and species from a quantitative LC-MS/MS platform. These data with 1018 molecular measures were analyzed in two population cohorts totaling 7830 participants. The association and cluster analyses revealed excellent coherence between the methodologically independent data domains and confirmed their quantitative compatibility and suitability for large-scale studies. The analyses elucidated the detailed molecular characteristics of the heterogeneous circulatory macromolecular lipid transport system and the underlying structural and compositional relationships. Unsupervised neural network analysis─the so-called self-organizing maps (SOMs)─revealed that these deep molecular and metabolic data are inherently related to key physiological and clinical population characteristics. The data-driven population subgroups uncovered marked differences in the population distribution of multiple cardiometabolic risk factors. These include, e.g., multiple lipoprotein lipids, apolipoprotein B, ceramides, and oxidized lipids. All 79 structurally unique triglyceride species showed similar associations over the entire lipoprotein cascade and indicated systematically increased risk for carotid intima media thickening and other atherosclerosis risk factors, including obesity and inflammation. The metabolic attributes for 27 individual cholesteryl ester species, which formed six distinct clusters, were more intricate with associations both with higher─e.g., CE(16:1)─and lower─e.g., CE(20:4)─cardiometabolic risk. The molecular details provided by these combined data are unprecedented for molecular epidemiology and demonstrate a new potential avenue for population studies.</p><p>Lipoprotein lipids have had a central role in clinical risk assessment for cardiometabolic diseases since the 1950s. <a href="javascript:void(0);" aria-label="reference 1">(1)</a> The realization that <sup>1</sup>H NMR spectroscopy would be inherently suited for lipoprotein analytics took place in the early 1990s. <a href="javascript:void(0);" aria-label="reference 2">(2)</a> In addition to the fundamental advantages of <sup>1</sup>H NMR spectroscopy in producing quantitative data, the spherical monolayered structure of lipoprotein particles provides a compelling attribute that the chemical shifts of lipid molecules transported by these particles are dependent on the particle diameter. This phenomenon arises from the orientational order of the surface lipids and the resulting anisotropy of the magnetic susceptibility, and leads to distinctive particle size-dependent frequency shifts. This facilitates comprehensive lipoprotein analytics that is pertinent to the metabolic constituents of the lipoprotein cascade. Practical applications and statistical considerations have indicated that 14 lipoprotein subclasses and their main lipid constituents can be robustly quantified. <a href="javascript:void(0);" aria-label="reference 3 and 4">(3,4)</a> Multiple commercial methodologies have also been developed. <a href="javascript:void(0);" aria-label="reference 5 to 7">(5−7)</a> Here we applied a platform that has been widely applied in large-scale epidemiology and genetics over the last 15 years with some 500 publications and 2 M samples analyzed, including all the 0.5 M serum samples in the UK Biobank. <a href="javascript:void(0);" aria-label="reference 3, 5 and 8">(3,5,8)</a> This particular platform has also played a key role in yielding open access genetic data, with the most recent genome-wide association study meta-analysis being carried out in 136,000 individuals. <a href="javascript:void(0);" aria-label="reference 9">(9)</a></p><p>Mass spectrometry based lipidomics methodologies have been developed independent of the above and are technologically more challenging than the applications of <sup>1</sup>H NMR spectroscopy. <a href="javascript:void(0);" aria-label="reference 10 to 12">(10−12)</a> Nevertheless, epidemiological applications have become feasible over the recent years and clinical translation has been suggested, for example, with respect to assessing cardiometabolic risk <a href="javascript:void(0);" aria-label="reference 13 and 14">(13,14)</a> and cognitive impairment. <a href="javascript:void(0);" aria-label="reference 15">(15)</a> Initial genetic studies have also been published. <a href="javascript:void(0);" aria-label="reference 16 and 17">(16,17)</a></p><p>The NMR spectroscopy and MS lipidomics approaches to lipid characterization and quantification are fundamentally different (<a target="_blank" rel="noopener noreferrer" href="https://pubs.acs.org/doi/10.1021/acs.analchem.4c03229#fig1" data-tab="pane-pcw-Figures" id="">Figure 1</a>). In NMR the serum sample is directly analyzed with the lipoprotein particles intact; this allows quantification of the comprehensive and specific data on the lipoprotein subclasses and lipids. <a href="javascript:void(0);" aria-label="reference 18">(18)</a> Unlike NMR, LC-MS/MS lipidomics calls for lipid extraction of the serum samples as an integral prerequisite for the analyses. <a href="javascript:void(0);" aria-label="reference 19">(19)</a> The lipidomics sample preparations thus represent pooled mixtures of all the lipid molecules from all the circulating lipoprotein particles. All the information from the specific lipoprotein origin of a certain lipid in the circulation is lost in the extraction phase. However, with LC-MS/MS hundreds of unique lipid species can be analyzed from dozens of different molecular lipid classes. <a href="javascript:void(0);" aria-label="reference 12 and 20">(12,20)</a></p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Anal_Chem_2024_96_52_20362_20370_Figure_1_Schematic_illustration_of_the_methodological_differences_and_analytical_characteristics_between_1_H_NMR_and_LC_MSMS_lipidomics_and_their_molecular_views_into_serum_b9907a5e30.jpeg" alt="Anal. Chem. 2024, 96, 52, 20362-20370: Figure 1. Schematic illustration of the methodological differences and analytical characteristics between 1H NMR and LC-MS/MS lipidomics and their molecular views into serum lipids. (A) The lipoprotein analysis with NMR is performed directly from the intact serum sample. (B) For the LC-MS/MS analysis all the lipids need to be extracted to a homogeneous lipid-soluble mixture. This allows LC-MS/MS to reach detailed molecular quantification, however, as a total serum concentration without any information on the originating lipoproteins. (C,D) The NMR analysis gives molecular information on 14 lipoprotein subclasses with the abundant core and surface lipids quantified. The percentages depict the compositional variation of these lipids in different lipoprotein particles." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Anal_Chem_2024_96_52_20362_20370_Figure_1_Schematic_illustration_of_the_methodological_differences_and_analytical_characteristics_between_1_H_NMR_and_LC_MSMS_lipidomics_and_their_molecular_views_into_serum_b9907a5e30.jpeg 192w," sizes="100vw" width="947" height="771"></p><p>Lipoprotein particles are the sole transport vehicles for all lipid molecules in serum, <a href="javascript:void(0);" aria-label="reference 18, 21 and 22">(18,21,22)</a> though albumin contains the bulk of free fatty acids and acylcarnitines, and transports also various lyso-type of lipid molecules. <a href="javascript:void(0);" aria-label="reference 23 and 24">(23,24)</a> The NMR and the LC-MS/MS data on serum essentially represent the same lipids as noted by Ghorasaini et al. <a href="javascript:void(0);" aria-label="reference 25">(25)</a> The NMR provides the size-resolution and metabolic information on lipoprotein particles (209 measures) and the LC-MS/MS lipidomics opens up a prolific and detailed molecular view on all the circulating lipids (809 measures).</p><p>These different methodologies and molecular views to study serum lipids have independently advanced toward large-scale population studies. Here, we integrate these state-of-the-art data─over 1000 quantitative molecular lipid measures per individual─in two large-scale population cohorts of over 7800 participants. These data reveal the fundamental relationships between the lipoprotein subclass cascade and metabolism (NMR) and the plethora of specific molecular information (LC-MS/MS). The molecular and metabolic corollaries are numerous, and we elaborate on some pertinent findings. Among the various analyses we also demonstrate the admirable coherence within the independent experiments and data domains. It is also uncovered─via data-driven, unsupervised neural network analysis─that these molecular lipid measures per se can be utilized for metabolically and clinically meaningful subgrouping of populations. The results illustrate that these combined comprehensive data lead to improved molecular characterization of population-level metabolic health and cardiometabolic risk.</p><h3><strong>Materials and Methods</strong></h3><h5><strong><sup>1</sup>H NMR Spectroscopy</strong></h5><p>We applied an NMR platform that has been widely used in epidemiology and for which the general methodological issues have been published. <a href="javascript:void(0);" aria-label="reference 3, 5, 8, 9 and 18">(3,5,8,9,18)</a> The separation of lipoprotein subclasses by proton NMR spectroscopy is based on particle size, <a href="javascript:void(0);" aria-label="reference 2">(2)</a> the platform resolution being 14 subclasses (<a target="_blank" rel="noopener noreferrer" href="https://pubs.acs.org/doi/10.1021/acs.analchem.4c03229#fig2" data-tab="pane-pcw-Figures" id="">Figure 2</a>). <a href="javascript:void(0);" aria-label="reference 3 and 18">(3,18)</a> Independent verification for the number of subclasses has been published by Mihaleva and co-workers with an in-depth handling of statistical grounds. <a href="javascript:void(0);" aria-label="reference 4">(4)</a> Particle (P), phospholipid (PL), free cholesterol (FC), cholesteryl ester (CE), and triglyceride (TG) concentrations are quantified for all 14 subclasses, also allowing calculation of the relative lipid composition for each lipoprotein subclass. The platform also provides all key clinically used lipid measures (e.g., total TG, cholesterol, and HDL-C) as well as apolipoprotein B (apoB) and A-I (apoA-I) concentrations. In total 209 lipoprotein-related measures were analyzed (98 concentration and 70 compositional measures from 14 lipoprotein subclasses, 19 clinical lipid measures, and 22 measures related to fatty acids, average particle sizes, and apoA-I and apoB).</p><h5><strong>LC-MS/MS Mass Spectrometry</strong></h5><p>Serum lipids were extracted as previously described. <a href="javascript:void(0);" aria-label="reference 19">(19)</a> The LC-MS/MS profiling was performed using the standardized methodology described recently by Huynh et al. <a href="javascript:void(0);" aria-label="reference 12">(12)</a> and updated with a larger set of targets. The mass spectrometric details and parameters are given in the <a target="_blank" rel="noopener noreferrer" href="https://pubs.acs.org/doi/suppl/10.1021/acs.analchem.4c03229/suppl_file/ac4c03229_si_001.pdf">Supporting Information</a>.</p><h3><strong>Conclusions</strong></h3><p>The presented combination of lipoprotein and lipid data from NMR spectroscopy and LC-MS/MS lipidomics led to an unprecedented metabolic and molecular detail with over 1000 measures per person in a population setting of over 7800 individuals. The analyses demonstrated notable coherence between the data from inherently different spectroscopic techniques. The data-driven analyses revealed multiple confirmatory and novel molecular results in relation to systemic lipid metabolism and illustrated the power of all-inclusive lipid data in understanding cardiometabolic population health, related clinical factors, and disease risk. The analyses emphasized the augmented value of interpreting lipidomics data (deep molecular phenotyping) together with lipoprotein data (deep metabolic phenotyping) and association heatmaps between all the lipidomics measures and the key measures characterizing lipoprotein subclass metabolism are provided. These unique motifs are useful as guidelines for the key lipoprotein mediators for various lipidomics associations in biomedical studies when comprehensive lipoprotein profiles are not available.</p>

Personalized Profiling of Lipoprotein and Lipid Metabolism Based on 1018 Measures from Combined Quantitative NMR and LC-MS/MS Platforms

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Since its establishment in 2011, CEITEC has quickly developed into a cutting-edge infrastructure for research which performs highly alongside the best institutes in Europe. Among the main priorities of CEITEC are the promotion of a motivating and dynamic international scientific environment, the provision of state-of-the-art research infrastructure, and the policy of open communication and equal opportunities.

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Mettler-Toledo

Anton Paar

Agilent Technologies

SPECTRO Analytical Instruments

<p><strong>Universities, research labs with interns and others, need analytical tools that are both easy to learn as teaching tools, while being flexible enough to satisfy the needs of a research environment.</strong></p>
<p>We will discuss each of the above techniques and outline the advantages and challenges of each.</p>
<blockquote>
<p><strong>Presenter:</strong> Paul Krampitz (Application Scientist, Agilent Technologies, Inc.)</p>
</blockquote>
<blockquote>
<p>Paul is a graduate of Bowling Green State University with a Chemistry Bachelor of Science degree. Twenty – five years of Spectroscopy experience mainly Inductively Coupled Plasma (ICP) Spectroscopy as well as ICP-MS and AAS. His experience also includes X-Ray Fluorescence (ED, WD), Laser Ablation, Inorganic Speciation and Microwave Plasma Spectroscopy. Market Segment expertise includes environmental, petrochemical, metallurgical applications.</p>
</blockquote>


Agilent Technologies: Learn Why Atomic Absorption, MicroWave, and ICP Plasma Spectroscopy are the Perfect Tools for Both a Teaching and Research Environment

Learn Why Atomic Absorption, MicroWave, and ICP Plasma Spectroscopy are the Perfect Tools for Both a Teaching and Research Environment

We will discuss each of the above techniques and outline the advantages and challenges of each.

Learn Why Atomic Absorption, MicroWave, and ICP

<p><strong>From Basic to Advanced of Scratch </strong>is a course with three sessions, in which participants will explore strategies for optimizing test parameters, defining critical loads, and utilizing advanced quantitative techniques such as wedge blade testing and coating recovery. This series is designed to enhance your ability to accurately assess and interpret scratch test data, providing insights that are directly applicable to a wide range of material testing scenarios.</p><h3><strong>February 4, 2025: Scratch Measurement Optimization</strong></h3><p style="margin:7.5pt 0in .0001pt;">Explore how to fine-tune scratch test parameters for your specific needs. This session covers defining critical loads, understanding indenter geometries, and optimizing test settings to focus on the most relevant aspects of scratch testing for your work. Whether you're assessing coatings or material durability, this webinar will equip you with practical strategies to enhance the accuracy and relevance of your scratch tests.<br><br>By the end of this webinar, attendees will be equipped with with a deeper understanding of how to define and apply critical loads for various materials, select the most appropriate indenter geometries, and optimize key test parameters for enhanced performance. You’ll leave with actionable techniques to tailor scratch testing to your specific applications, ensuring more precise, reliable, and relevant results in your material characterization efforts.</p><div><div><blockquote><p><strong>Presenter: </strong>Mark R Haase</p><p>Mark R Haase is an Advanced Application Scientist at Anton Paar, and has been with the company for six years. They work with many material characterization techniques, including scratch, indentation, tribology, particle sizing, gas sorption, atomic force microscopy, and rheology. Mark supports the use of these techniques in research and industry with training and method development. Prior to joining Anton Paar, Mark's studies included nanocarbon materials and green energy systems.</p></blockquote></div></div>

Anton Paar: Beyond the Surface Module 2 - Scratch Series: From Basic to Advanced Scratch

Scratch Measurement Optimization

Explore how to fine-tune scratch test parameters for your specific needs. 

Scratch Series: Scratch Measurement Optimization

<p><strong>Production of animal food is just as complex, costly and time-consuming as producing food for human consumption as the demand for safe, high-quality and nutritious animal foods has grown. Extrusion is the most widely used process for R&amp;D, formulation development and production of new animal foods.</strong></p><p>This webinar will introduce both single and twin-screw extrusion techniques for lab-scale animal food production. Additionally, ensuring consistent quality over the different production stages can be accomplished by controlling critical physio-chemical parameters of food ingredients such as moisture, refractive index, viscosity, density, oxidation stability and shelf-life.&nbsp;</p><div><div><blockquote><p><strong>Presenter: </strong>Helga Gschwind</p><p>Helga Gschwind is a Market Development Manager with Anton Paar USA focused on developing new markets for analytical, process and quality control instrumentation within the food industry. She received her engineering degree in food science from the National University of Lujan, Argentina and has worked for over 20 years in the food and beverage industry in quality, production, and engineering areas.</p><p><strong>Presenter:&nbsp;</strong>Debomitra Dey</p><p>Debomitra Dey is an Advanced Application Scientist with Anton Paar Inc., USA. Specializing in extrusion processing applications for snacks, meat analogs, and pet food, she loves diving into the creative challenges of her work. With a background spanning industry and academia, Debomitra thrives on collaboration, working closely with partners to innovate and excel. Before joining Anton Paar, she worked as a Food Extrusion Specialist with CW Brabender Instruments, Inc. NJ. She earned her Ph.D. in Food Science from Washington State University.</p></blockquote></div></div>

Anton Paar: Optimizing Animal Feed Production: Mixing, Extrusion, Texture, and Tribology

Optimizing Animal Feed Production: Mixing, Extrusion, Texture, and Tribology

This webinar will introduce both single and twin-screw extrusion techniques for lab-scale animal food production. 

Animal Feed: Mixing, Extrusion, Texture, Tribology

<p><strong>Tips and Techniques for Accurate Evaluations</strong></p><p><strong>Program</strong></p><ul><li>What is the glass transition temperature (Tg) and why it is important</li><li>Introduction to the glassy state and transition effects on material properties</li><li>Measurement techniques for determining Tg (DSC, TMA, and DMA)</li><li>Example applications for different industries</li><li>Interactive Q&amp;A</li></ul><p><strong>The glass transition is the transformation of a substance from a glassy to a rubbery state, or vice versa. Knowing the temperature at which this transformation occurs is critical for understanding a material’s properties and behavior and how it can be used.</strong></p><p>Thermal analysis offers several ways to determine the glass transition temperature (Tg): differential scanning calorimetry (DSC), thermomechanical analysis (TMA), and dynamic mechanical analysis (DMA).</p><p>Join our webinar to discover the effectiveness of these techniques using a variety of application examples.<br>Why is knowledge of the glass transition so important?</p><p>The glass transition provides information about the molecular properties of a material as it is heated or cooled within a certain range. It defines the upper temperature limit for the use of solid amorphous materials, and the lower temperature limit for rubbery materials. It can also provide information about the degree of cure.</p><p>Knowing the glass transition is important for optimizing production parameters and material properties. In addition, the Tg can be used to identify and compare materials and is therefore important in quality control and in failure analysis.</p><p>Join the webinar to expand your knowledge and improve your understanding of this critical property. Don’t forget to have your questions ready for our experts!</p><ul><li><strong>30.1.2025 8:00, English</strong></li><li><strong>30.1.2025 16:00, English</strong></li></ul><blockquote><p><strong>Presenter: </strong>Angela Hammer (Dr. sc. nat. ETH)</p><p>Dr. Angela Hammer received a Ph.D. in Analytical Chemistry (development of immobilized components for the use in ion-selective electrodes based on polyurethane membranes) from the Institute of Organic Chemistry at the Swiss Federal Institute of Technology in Zürich, Switzerland. She then joined Sika Technology AG in Zurich, Switzerland, as an analytical chemist. In 2007, she joined METTLER TOLEDO and has worked there since as an application specialist for Thermal Analysis. In her present position, she uses, teaches, and supports DSC, TGA, TMA, and DMA instruments for the METTLER TOLEDO’s Materials Characterization Group located at the head office in Switzerland.</p></blockquote>

Mettler-Toledo: Live Webinar: How to Determine the Glass Transition by Thermal Analysis

Live Webinar: How to Determine the Glass Transition by Thermal Analysis

Join our webinar to discover the effectiveness of techniques such as Tg, DSC, TMA and DMA using a variety of application examples

How to Determine the Glass Transition by Thermal Analysis 

<p><strong>The pharma industry and data integrity can be mentioned in the same breath, including Anton Paar's measuring equipment, where data protection is integral to the device.</strong></p><p>Data integrity has now been extended from the device to the AP Connect Pharma edition. This software allows you to store, verify, and validate your data easily in your own SQL database. Now there is also the possibility to link non-Anton Paar devices with this software allowing us to automate your entire lab!</p><p>To show you all the possibilities of data integrity on our devices and AP Connect, we are setting up a webinar 'Data Integrity' on February 6th, 2025, from 10 am till noon.</p><p><strong>During this webinar, we will cover topics such as:</strong></p><ul><li>Pharma Qualification according to 21 CFR part 11 of your device and software</li><li>Data Integrity with Audit Trail at device and software level</li><li>AP Connect Pharma client-server-based software for verification, and validation with the possibility of Active Directory</li><li>Virtual demonstration</li></ul><p><strong>Guest speakers Georg Roth and Wolfgang Zichner</strong>, from Anton Paar GmbH, and our Belgian specialists will guide you through this interesting subject matter.</p><p>On top of this, all participants receive our specially designed e-book "Field Guide to Data Integrity in Regulated Industries" and a coffee break package*</p><p>* will only be sent to participants in Belgium and Luxembourg.</p>

Anton Paar: Data Integrity - the Anton Paar way

Data Integrity - the Anton Paar way

Data integrity has now been extended from the device to the AP Connect Pharma edition. This software allows you to store, verify, and validate your data easily.

<h4><strong>Eight Webinars and a Roundtable with Experts from Merck</strong></h4><p><strong>Analytical Excellence Week' is organized to empower professionals in the field of analytical chemistry. Over the course of eight insightful sessions, industry experts will share their knowledge and best practices to streamline your analytical workflows and enhance your efficiency.</strong></p><p>From <strong>understanding quality grades</strong> in inorganics and solvents to <strong>exploring sustainable practices</strong> in the lab, each webinar covers essential topics that will enhance your analytical capabilities. Learn how to <strong>optimize your Karl Fischer titration</strong>, achieve precision in PFAS testing, and gain <strong>troubleshooting tips for LC-MS</strong> to effectively address common challenges and improve your laboratory results.</p><p>The sessions will also address critical aspects of <strong>safety and sustainability</strong>, ensuring you are well-equipped to handle hazardous chemicals responsibly while making strides toward greener laboratory practices.</p><p>This is an invaluable opportunity to gain insights that can significantly optimize your analytical processes. Don’t miss your chance to elevate your expertise and contribute to a more efficient and sustainable future in analytical workflows.</p><p>Each session is specifically designed to address essential topics that directly impact your daily practices, making it relevant for all professionals working in a chemical analysis laboratory.</p><h3><strong>Day 1: Monday, 10 February</strong></h3><h4><strong>Navigating Quality Grades Part 1: Inorganics and Solvents for Classical Analysis and Research</strong></h4><p><strong>Join us for an insightful webinar focused on the critical process of selecting the right quality grade for inorganic reagents and solvents used both in analytical and research applications. We will provide an in-depth overview of various quality grades, including ACS grade and EMSURE®, and discuss their specific attributes, including purity, regulatory support, and packaging. Gain valuable insights into the importance of this choice and its impact on the quality of your lab processes and outcomes.</strong></p><p><strong>By attending this webinar, you will:</strong></p><ul><li>Understand the significance of choosing the right quality grade for your lab applications</li><li>Explore the available quality grades, including ACS grade and EMSURE®, and their specific attributes</li><li>Recognize the impact of quality grade selection</li><li>Learn best practices for selecting and utilizing the appropriate quality grade for several applications</li></ul><p><strong>Who should attend:</strong></p><p>This webinar is designed for professionals involved in laboratory work who seek to enhance their understanding of quality grades for inorganic reagents and solvents. It is particularly relevant for lab technicians, researchers, and managers in analytical labs (like QC, environmental, etc.) method development and research laboratories that are looking to optimize their processes and outcomes.</p><blockquote><p><strong>Presenter:</strong> Christian Roth (Senior Product Manager Inorganics, Merck)</p><p><strong>Presenter:</strong> Lyra Christianson (Product Manager Solvents, Milwaukee, Wisconsin, USA, an affiliate of Merck)</p></blockquote><h4><strong>Navigating Quality Grades Part 2: Solvents and Reagents for Chromatography Applications</strong></h4><p><strong>This second part focuses on the critical process of selecting the right quality grades used in chromatography applications. We provide an in-depth overview of various quality grades, from Suprasolv® solvents for GC to LiChrosolv® solvents for HPLC, in combination with LiChropurTM reagents, and discuss their specific attributes, including purity, regulatory support, and packaging. The topic will be illustrated by typical HPLC and LC-MS applications.</strong></p><p><strong>By attending this webinar, you will learn:</strong></p><ul><li>Which grades are suitable for which chromatographic analysis</li><li>What are the specific attributes of the solvents and reagents</li><li>How to combine different quality grades meaningfully</li><li>How to identify and differentiate between various quality grades of reagents and solvents.</li><li>To understand the critical importance of selecting the appropriate quality grade for your specific analytical applications</li></ul><p><strong>Who should attend</strong></p><p>Lab technicians, lab managers, and quality control-related persons who need to understand how to select the different quality grades for HPLC and LC-MS applications.</p><blockquote><p><strong>Presenter: </strong>Patric Klein, (Global Product Manager Organic and Inorganics Instrumental Analysis, Merck)</p><p><strong>Presenter: </strong>Fernando Luengo, (Global Product Manager HPLC Solvents, Milwaukee, Wisconsin, USA, an affiliate of Merck)</p><p><strong>Presenter: </strong>Daniel Weibel, (Global Product Manager Solvents, Merck)</p></blockquote>

Merck: Webinar Series & Expert Roundtable

Webinar Series & Expert Roundtable (Day 1)

Navigating Quality Grades Part 1: Inorganics and Solvents for Classical Analysis and Research and Part 2: Solvents and Reagents for Chromatography Applications

<p><strong>Higher Quality and Greater Productivity</strong></p><p><strong>The impact pH has on food quality and safety is significant. For decades, food producers have used the pH value determined by sampling, to check the progress of production processes. However, a sample only provides an insight into production at the time it was taken. In addition, significant labor and time are involved in taking and analyzing samples.</strong></p><p>In this webinar, the presenter will show that it is not only the labor and effort in lab determination of pH that can be issues; opportunities to react timely to incorrect operations can be missed, and undesirable microorganism activity and the accidental dosing of CIP detergents can be spotted late. Such event leads to time-consuming and costly efforts for correction.</p><p>We will look at how the continuous monitoring of pH with in-line sensors can avoid all these issues, and the positive impact real-time pH data can have on product quality, production costs, process safety, and production planning.</p><p>In-line measurement of pH in food and beverage processing has been hampered by the fragility of glass pH sensors. We will present a new, unbreakable pH sensor that provides the accuracy and speed of response of glass pH sensors, opening up opportunities to measure in-line with safe and easy-to-handle technology, and improve dairy processing. The sensor's properties in operation and during CIP will also be discussed.</p><p><strong>Program:&nbsp;</strong></p><ul><li>The impact of pH on dairy production</li><li>Issues with lab pH measurement</li><li>The value of continuous pH data</li><li>How the latest pH measurement systems can improve dairy processing</li></ul><p><strong>4. 2. 2025 9:00, CET</strong><br><strong>4. 2. 2025 16:00, CET</strong><br>&nbsp;</p><blockquote><p><strong>Presenter: </strong>Holger Schmidt (Mettler Toledo)</p><p>Holger Schmidt backs up his practical know-how as brewer and malster with a brewmaster degree from TUM Weihenstephan. For two decades he has been globally mediating the triangle between Food and Beverage producers, plant and machine builders, and automation companies, with a focus on hygienic sensor technologies.&nbsp;</p></blockquote>

Mettler Toledo: Improve Dairy Processing 

Improve Dairy Processing 

The impact of pH on dairy production, issues with lab pH measurement and how the latest pH measurement systems can improve dairy processing.

<p><strong>Food and environment testing labs face many challenges and are under pressure to maximize efficiency, productivity, and profitability. Customers expect rapid analysis, with testing done using best-in-class instrument and methods that comply with constantly evolving test regulations. Agilent provides instrumentation, software, consumable, services, and support to help you meet your food and environment testing challenges.</strong></p><p>In order to increase the effectiveness and productivity of elemental analysis in food and environmental samples, in this first session we will exchange tips and the newest Agilent technology available.</p><blockquote><p><strong>Presenter:&nbsp;</strong> Dr. Nopparat Vorapalawut (Spectroscopy Solutions Development Manager, Agilent Technologies)</p><p>Nopparat joined Agilent Technologies in position of Spectroscopy Application Field Service Engineer and is currently Agilent’s Spectroscopy product specialist based in Thailand.</p><p>She graduated Ph.D. in Analytical Chemistry and having previously worked in post-doctoral researcher in France and join Agilent in 2016.</p><p>At Agilent, she is supporting in technical sales and requirement from customers.</p></blockquote>

Agilent Technologies: Optimizing your food environmental testing: Expert tips and insights with atomic and molecular spectroscopy

Atomic Spectroscopy

To boost effectiveness and productivity of elemental analysis in food and environmental samples, we´ll exchange tips and the newest Agilent technology available

Session 1: Atomic Spectroscopy

<h5><strong>By attending this webinar, you will learn about:</strong></h5><ul><li>The most common causes of unplanned downtime and inconsistent results, and what you can do to reduce this unplanned downtime.</li><li>New sample introduction components for ICP-OES that improve analytical performance and reduce blockages when analyzing challenging sample matrices.</li><li>Essential operational tips and guidelines that can help you improve the performance of your ICP-OES when analyzing challenging sample matrices.</li></ul><h5><strong>Event Overview</strong></h5><p>Improving efficiency in routine analyses in your lab is crucial and should be a priority for any lab. Running challenging sample matrices using the ICP-OES technique poses many challenges for your analysts. They risk unplanned downtime from potential nebulizer or injector blockage, or other sample related issues. This sacrifices your sample throughput as your analysts need to first solve the issues – and then re-run samples where the results have been impacted by the loss of sensitivity from the partial or complete blockage. Challenging sample matrices can also increase your cost of ownership as components that wear need more frequent replacement.</p><p>In this webinar, we'll provide an overview of some new sample introduction components that remove those pain points around running challenging sample matrices by ICP-OES efficiently. We’ll highlight the unique design features that enhance the total dissolved solid and particle handling capabilities, reducing the risk of nebulizer and injector blockage.</p><p>We’ll demonstrate the capabilities of this robust sample introduction system with two challenging sample matrices, including used lubricating oils, where carbon build-up and larger wear metal particles can create a blockage risk. The second matrix is “black mass” – the material created when lithium-ion batteries are shredded and processed in battery recycling facilities. This complex mixture includes high concentrations of valuable minerals including lithium, which can cause rapid and premature degradation of the injector, combined with insoluble suspended carbon particles, which can also create a blockage risk.</p><h5><strong>Who Should Attend:</strong></h5><p>This webinar is recommended for any analyst or lab manager looking to improve efficiency and reduce downtime in their routine analysis workflows when running challenging sample matrices with their ICP-OES analyses, by utilizing a robust sample introduction system.</p><blockquote><p><strong>Presenter: </strong>James Dellis (ICP-OES Supplies Product Manager, Agilent, Melbourne, Australia)</p><p>James graduated from Swinburne University of Technology with a Bachelor of Science degree majoring in Chemistry and Biochemistry. Prior to joining Agilent, he worked within the Geochemical and Precious Metal industry. James joined Agilent in 2017 as an R&amp;D Applications Chemist for Supplies Product Development and is now the ICP-OES and Molecular Supplies Product Manager. He has over 13 years' experience in Analytical Chemistry and Atomic Spectroscopy. He is based at Agilent’s Spectroscopy Technology Innovation Centre in Melbourne, Australia.</p><p><strong>Presenter: </strong>Alejandro Amorin (Atomic Spectroscopy Applications Chemist, Agilent, Melbourne, Australia)</p><p>Alejandro Amorin graduated from Universidad Central de Venezuela in Caracas, Venezuela with a Bachelor of Science degree with Honors, majoring in Chemistry. Prior to joining Agilent, Alejandro worked as a Research Chemist with DCG Partnership, developing new calibration standard blends for GC methods. Alejandro joined Agilent in 2012 as an Applications Chemist. He has worked on development of new spectroscopy consumables and provided applications support for Agilent spectroscopy instrument users around the world. Through his work experience, he has years of hands-on experience in diverse instrumental analysis techniques, including GC, IC, HPLC, AAS &amp; ICP combined with classical wet chemistry techniques. He is based at Agilent’s Spectroscopy Technology Innovation Centre in Melbourne, Australia.</p><p><strong>Presenter: </strong>Eric Vanclay (Marketing Director - Spectroscopy Supplies, Agilent, Melbourne, Australia)</p><p>Eric Vanclay graduated from Monash University in Melbourne, Australia with a Bachelor of Science degree majoring in Chemistry in 1985, and has since completed further postgraduate studies in Marketing. He joined Varian in 1988 and has worked in a number of roles including Atomic Absorption Product Specialist, Atomic Absorption Product Manager, Export Marketing Manager, European Field Sales/Applications Specialist (atomic spectroscopy), ICP-OES Product Manager and MP-AES Product Manager. After the acquisition of Varian by Agilent, Eric took on the role of Spectroscopy Supplies Marketing Manager, with responsibility for field sales support, customer support, product development and marketing of the spectroscopy supplies. He has over 30 years' experience with all of the atomic spectroscopy techniques. He is based at Agilent’s Spectroscopy Technology Innovation Centre in Melbourne, Australia.</p></blockquote>

Separation Science: Improving Efficiency with Challenging ICP-OES Applications Utilizing a Robust Sample Introduction System

Improving Efficiency with Challenging ICP-OES Applications Utilizing a Robust Sample Introduction System

We'll provide an overview of some new sample introduction components that remove pain points around running challenging sample matrices by ICP-OES efficiently. 

Improving Efficiency with Challenging ICP-OES Applications 

<p><strong>Achieving exceptional accuracy in elemental analysis requires methods that balance precision and efficiency. The bracketing technique has long been the gold standard for ICP-OES, offering reliable correction for intensity drift through meticulous calibration cycles. However, Dynamic Measurement Correction (DMC) provides a modern alternative, dramatically reducing analysis time while maintaining comparable accuracy.</strong></p><p>Recent studies demonstrate that DMC achieves up to 5 times faster results without compromising performance, making it an ideal solution for industries where time-sensitive analysis is critical. Whether prioritizing precision or speed, both approaches deliver dependable outcomes, ensuring consistent and reproducible ICP-OES results across diverse applications.</p><p>Join our live-webinar to discover all about this exciting techniques. The webinar will take place on <strong>Thursday, January 30</strong>, and will take around 30 minutes, after which we'll answer your questions live.</p><ul><li><strong>9:30 CET</strong></li><li><strong>17:00 CET</strong></li></ul><blockquote><p><strong>Presenter: </strong>Dr. Marcus Gantenberg (Ph.D. in physical-organic chemistry from the Ruhr University of Bochum, Germany)</p><p>Dr. Marcus Gantenberg holds a Ph.D. in physical-organic chemistry from the Ruhr University of Bochum, Germany. Marcus joined SPECTRO in 2007 and gained extensive experience in various fields of spectroscopy. As an application scientist for ICP-OES, Marcus has worked on many technology projects and supported a large number of customers.</p></blockquote>

High Precision Analysis with ICP-OES: Bracketing vs. Dynamic Measurement Correction

High Precision Analysis with ICP-OES: Bracketing vs. Dynamic Measurement Correction - Join our live-webinar to discover all about this exciting techniques.