Our Library never stops expanding. What are the most recent contributions to LabRulezICPMS Library in the week of 6th April 2026? Check out new documents from the field of spectroscopy/spectrometry and related techniques!<blockquote>👉 <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/library">SEARCH THE LARGEST REPOSITORY OF DOCUMENTS ABOUT SPECTROSCOPY/SPECTROMETRY RELATED TECHNIQUES</a></blockquote><blockquote>👉 Need info about different analytical techniques? Peek into <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/library">LabRulezLCMS</a> or <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library">LabRulezGCMS</a> libraries.</blockquote>This week we bring you application notes by Metrohm, Shimadzu, Thermo Fisher Scientific and Waters Corporation!<h3>1. Metrohm: Whey permeate analysis with NIRS</h3>Monitor dairy production processes easily in seconds<ul><li>Application note</li><li><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/labrulez-bucket-strapi-h3hsga3/an_nir_144_download_34598659f1.pdf">Full PDF for download</a></li></ul>Whey permeate, a byproduct of manufacturing whey protein powder, contains high amounts of lactose, phosphate, and minerals. Because of its sweet and mild taste, whey permeate is often used in bakeries and chocolate manufacturing. The key to optimizing whey permeate production is to control production streams in real time. It is important to monitor the production process with highthroughput analytical techniques to maximize product yield and ensure high product quality.&nbsp;Nearinfrared spectroscopy (NIRS) is a fast, and chemicalfree analysis technique that can support this kind of testing. NIR spectroscopy can measure the most important quality parameters (i.e., protein, lactose, moisture, ash, pH, and phosphate) simultaneously in whey permeate without any sample preparation. The NIRS solution is fast, easy to operate, and can be used atline or offline in a quality control lab.<h4>EXPERIMENTAL EQUIPMENT&nbsp;</h4>158 whey permeate samples were analyzed on a <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/library?mainauthorItems=220&amp;search=NIR+analyzer">Metrohm NIR Analyzer</a> equipped with a small cup accessory. All measurements were performed in reflection mode (1000–2250 nm). Metrohm software was used for data acquisition and prediction model development.<h4>CONCLUSION&nbsp;</h4>This Application Note demonstrates the feasibility of using NIR spectroscopy for whey permeate quality control. Near infrared-spectroscopy is a rapid, nondestructive analytical technique that can monitor the production process of dairy products. Aside from the analysis of whey permeate, the whey protein production stream can also be monitored by NIRS.<h3>2. Shimadzu: Measurement of Residual Metal Catalysts by X-ray Fluorescence</h3><ul><li>Application note</li><li><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/labrulez-bucket-strapi-h3hsga3/an_01_01086_en_4beb25fd1d.pdf">Full PDF for download</a></li></ul><h4>User Benefits</h4><ul><li><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/library?mainauthorItems=1&amp;search=ALTRACE">ALTRACE</a> can determine levels of heavy metals present in organic compounds at around 1 mg/kg in under 10 minutes per sample.</li><li>Analyzing and managing levels of residual metal catalysts can be performed by simply placing samples in the sample vessel and analyzing them without the need for complex sample pretreatment.</li><li>By increasing the X-ray tube power and optimizing the optical design, the sensitivity of ALTRACE for heavy metals has been dramatically improved compared to the previous model.</li></ul>Many industrial products we encounter every day are produced from organic compounds by manufacturing processes that utilize a range ofsynthesisreactions and metal catalysts. Catalysis can be classified as either homogeneous or heterogeneous (although drug and chemical production processes typically use homogeneous catalytic systems). While homogeneous catalysis allows for precise control over catalytic reactions, recovering the catalyst after the reaction can be difficult.&nbsp;Nevertheless, managing the levels of residual catalysts in industrial products is critical to ensure safety and because of their high costs. For example, the ICH Q3D Guideline for Elemental Impurities (adopted in April 2017) requires risk assessments when materials such as metal catalysts are added intentionally during a production process.&nbsp;Energy dispersive X-ray fluorescence (EDXRF) spectrometry offers a simple but effective technique for assessing the levels of residual metal catalysts. Normally, the lower limit of quantification for EDXRF spectrometric analysis of heavy metals is above 1 mg/kg, which limitsits use in quantitative analysis. However, the <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/library?mainauthorItems=1&amp;search=ALTRACE">ALTRACE</a> is equipped with a high-power X-ray tube that dramatically improves its sensitivity for heavy metals, enabling their determination at 1 mg/kg and below in lessthan 10 minutes. This Application News describes using ALTRACE to determine residual levels of a homogeneous catalyst after a synthesis reaction. The catalyst used in this analysis is palladium (Pd), which is a widely applied heavy metal catalyst, and the reaction catalyzed by the Pd catalyst is a cross-coupling reaction. A metal scavenger and activated carbon were each used to remove the Pd catalyst from the reaction products. Metal scavengers are frequently used in this role, and activated carbon offers a relatively cheap method for removing catalysts.<h4>Conclusion&nbsp;</h4>Common methods of elemental impurity analysis, such as atomic absorption spectrometry (AAS), ICP atomic emission spectroscopy (ICP-AES), and ICP mass spectrometry (ICP-MS), require liquid samples, so solid and powder samples must be prepared into a solution prior to analysis. However, EDXRF spectrometry can determine levels of elemental impurities regardless of the sample phase or form (solution, powder, etc.), provided the target element is distributed uniformly throughout the sample. The sensitivity of ALTRACE for heavy metals has been substantially improved compared to previous models, allowing for rapid quantitative determination of heavy metals at 1 mg/kg and below. Based on the performance presented in this article, ALTRACE is an effective tool for managing residual levels of metal catalysts.<h3>3. Thermo Fisher Scientific: The Raman Spectroscopy of Graphene and the Determination of Layer Thickness</h3><ul><li>Application note</li><li><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/labrulez-bucket-strapi-h3hsga3/raman_spectroscopy_graphene_determination_layer_thickness_an52252_29274e8aea.pdf">Full PDF for download</a></li></ul>Currently, a tremendous amount of study is being directed toward graphene. This interest is driven by the novel properties that graphene possesses and its potential use in a variety of application areas that include but are not limited to electronics, heat transfer, bio-sensing, membrane technology, battery technology and advanced composites. Graphene exists as a transparent two-dimensional network of carbon atoms. It can exist as a single atomic-layer thick material, or it can be readily stacked to form stable, moderately thick samples containing millions of layers—a form generally referred to as graphite. However, the interesting properties exhibited by graphene (substantial electrical and thermal conductivity, high mechanical strength, and high optical transparency) are only observed for graphene films that contain only one or a few layers. Therefore, developing technologies and devices based upon graphene’s unusual properties requires accurate determination of the layer thickness for materials under investigation. Raman spectroscopy can be employed to provide a fast, non-destructive means of determining layer thickness for graphene thin films.<h4>Instrument considerations&nbsp;</h4>There are a few specifications that should be considered when selecting a Raman instrument for graphene characterization. First, since graphene samples are usually very small, selecting a Raman instrument with microscopy capabilities is imperative.The next issue to consider is which excitation laser to select. While graphene measurements can be made successfully with any of the readily available Raman lasers, it is also important to consider the substrate that the graphene will be deposited onto. It is common for graphene to be deposited on on either Si or SiO2 substrates, and both of these materials can exhibit fluorescence with near-infrared (NIR) lasers such as 780 nm or 785 nm. For this reason, visible lasers are usually recommended, typically a 633 nm or 532 nm laser.&nbsp;Next, since relatively small wavenumber shifts can significantly impact the interpretation of the Raman spectra, it is crucial to have a robust wavelength calibration across the entire spectrum. Using a single point wavelength calibration with some other applications may be sufficient, but this only ensures that one wavelength is calibrated and leaves room for a large margin of error. A multipoint wavelength calibration that is regularly refreshed, such as the standard calibration routine used with <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/products?category=184&amp;manufacturerItems=3&amp;search=dxr3">Thermo Scientific DXR3 Raman instruments</a>, will provide considerably more confidence in the results. It is also necessary to have an instrument with high wavenumber precision to observe small wavenumber shifts when altering the sample. In fact, small wavenumber shifts can represent changes in the sample rather than represent the variability from the instrument. There is a common myth that it is necessary to utilize high resolution in order to achieve high wavenumber precision. Not only is this incorrect, but a high resolution will actually add considerable noise to the spectrum, which will add to the wavenumber variability. A high degree of wavenumber precision, such as that provided by the <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/products/2239">Thermo Scientific™ DXR™3 Raman Microscope</a>, will significantly improve data confidence even when you are evaluating band shifts from low levels of strain or doping. It is also important to have exact control of your laser power at the sample and be able to adjust that laser power in small increments. This is important to control temperature-related effects and to provide flexibility to maximize Raman signal while still avoiding sample heating or damage from the laser. The DXR3 Raman systems are equipped with a unique device called a laser power regulator, which maintains laser power with unprecedented accuracy and provides exceptional ability to fine-tune laser power and optimize it for each experiment.1&nbsp;Lastly, the Raman microscope must have an automated stage and associated software to generate detailed Raman point maps. As will be seen in the next section, Raman point mapping or imaging extends the single point measurement to assess a sample’s layer thickness uniformity. The Thermo Scientific OMNIC™ Software suite contains powerful mapping and processing tools that diminish the complexity of collecting highly detailed maps and interpreting their results.<h4>Conclusions&nbsp;</h4>Raman spectroscopy is an excellent tool for the characterization of graphene and layer thickness. Few techniques will provide as much information about the structure of graphene samples as Raman spectroscopy, and any lab doing graphene characterization without Raman would be at a significant disadvantage. The DXR3 Raman Microscope is an ideal Raman instrument for graphene characterization because it can provide the high level of stability, control, and sensitivity needed to produce confident results.<h3>4. Waters Corporation: See What’s Really in Your Formulation with Backgrounded Membrane Imaging</h3><ul><li>Application note</li><li><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/labrulez-bucket-strapi-h3hsga3/720009098_en_5d36d71789.pdf">Full PDF for download</a></li></ul>Protein aggregation in therapeutic protein products can induce adverse immunogenic responses in patients1–4 . Per the FDA’s recommendations, “strategies to minimize aggregate formation should be developed as early as feasible in product development”5 and “an assessment should be made of the range and levels of subvisible particles (2–10 µm) present in therapeutic protein products initially and over the course of the shelf life”.5 Yet, accurate subvisible protein aggregation analysis has remained elusive to protein drug formulators since current subvisible analyzers are not sensitive enough to measure protein aggregates effectively. In this application note, we explore how backgrounded membrane imaging (BMI), a high refractive index contrast technique used by the HORIZON particle analysis system, performs highly sensitive measurements of subvisible protein aggregates in the 2 µm–4 mm size range, enabling 30% higher reproducibility compared to flow imaging.<h4>Conclusion&nbsp;</h4>When studying the impact of protein aggregate refractive index, IgG protein aggregates analyzed on both the <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/library?mainauthorItems=5&amp;search=HORIZON">HORIZON® instrument</a> and flow imager systems produced equivalent particle count trends. However, the HORIZON® system was more sensitive (measured more overall counts) and had overall lower variability with average CVs of 14.4% compared to the flow imager which produced average CVs of 20.1%. The differences in variability and counts were most pronounced at lower concentrations and size range respectively. Given that most particles in a therapeutic drug formulation are small, the inability of flow imagers to accurately count the smallest of protein aggregates has a dramatic impact on the total number of particles measured. This can mean an undercounting by as much as 3–10X depending on the protein and formulation conditions.&nbsp;High variability at low concentrations in flow imagers can pose a hurdle for early stage analysis were sample is scarce. In low volume analysis (&lt;250 µL), the possibility of measuring fewer particles increases, therefore it is imperative to have high sensitivity measurements when already challenged by low sampling statistics.&nbsp;In the excipient effect study, sucrose did not have an impact on the overall particle counts when measured using the HORIZON® system. This contrasts with previous studies comparing excipient effects on three flow imagers.10 In each case, the particle counts decreased up to 30% or more using standard sucrose formulation concentrations of 0–20%. The difference between the data generated by BMI and FI can be attributed to the fact that the HORIZON® instrument is not affected by particle or solution refractive index.&nbsp;Flow imagers are deeply vulnerable to the impact of refractive index when measuring protein aggregates due to their translucency and the negative impact of surfactants. Due to this basic optical phenomenon, flow imagers can dramatically undersize and undercount particles. Finding the right tool for the job will have a critical impact on data accuracy and sensitivity. Powered with BMI, the HORIZON® system provides high refractive index contrast analysis to enable accurate, robust, and sensitive subvisible particle counting from 2 µm–4 mm in as little as 25 µL of sample and 96 samples in under 2 hours.

News from LabRulezICPMS Library - Week 15, 2026

The set of soils consist of two natural agricultural soils differing in elemental composition&nbsp;<ul><li>AN-ZP01: Heavy loam with normal analyte levels&nbsp;</li><li>AN-ZP02: Silty clay loam contaminated with some heavy metals&nbsp;</li></ul>Contents of element extractable fractions with aqua regia according to ISO 11466&nbsp;<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/ANALYTIKA_agricultural_soil_CRM_0534e68e65.jpg" alt="ANALYTIKA: Matrix CRM of agricultural soil METRANAL® CRM AN-ZP01 and AN-ZP02" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_ANALYTIKA_agricultural_soil_CRM_0534e68e65.jpg 156w," sizes="100vw" width="827" height="827"><h5>Packing:&nbsp;</h5><ul><li>50 g of powder of the respective soil with a particle size of less than 100 µm in amber glass bottle.&nbsp;</li></ul><h5>Intended use:&nbsp;</h5>This set of certified reference materials is intended primarily for use in realizing metrological traceability, validation of analytical methods and the transfer of property values to other materials of similar composition.&nbsp;<h5>Recommended analytical methods for method dependent measurements:</h5><ul><li>Flame AAS, ETA-AAS, ICP-OES, ICP-MS, AMA-254&nbsp;</li></ul><h5>Metrological traceability:&nbsp;</h5>Metrological traceability is realized by using certified calibration standards solutions for the calibration of measurement methods used (direct traceability to SI unit) and/or by simultaneous analysis of a matrix CRM (RM) of similar composition.<h5>Sample preparation (aqua regia extract according to ISO 11466):&nbsp;</h5>Weigh a 3 g (± 0.001 g) sample into a 100 ml round bottom flask. Add a small amount of water (2 to 3 ml) to obtain a slurry, then 7.5 ml of conc. HNO3 (density 1.40 g/ml). Let the mixture stand until intensive foaming ceases, then add (in several portions) 22.5 ml of conc. HCl (density 1.19 g/ml), shake the mixture manually, cover the flask with a watch glass, and let stand for 16 hours (overnight) at the laboratory temperature (20 ± 2°C). Then mount a reflux condenser (a Dimroth type or similar) of about 40 cm length on the top of the flask and boil gently under reflux for 2 hours. After cooling, rinse the condenser with 20 ml of warm (~ 50°C) dilute nitric acid (5%, v/v), the liquid being collected in the round bottom flask. Remove the condenser and filter the solution from the flask through an acid-resistant high density paper filter and collect it in a 100 ml volumetric flask (make sure in preliminary tests that a suitable filter was chosen, so that the filtrate is clear). Rinse the filter and the residue three times with 5 ml of warm (~ 50°C) dilute nitric acid (5%, v/v); allow to cool and dilute with nitric acid 5% (v/v) to the mark. Transfer immediately the solution from the volumetric flask into a clean, dry 100 ml polyethylene bottle. Realize three blanks using exactly the same analytical procedure.&nbsp;It is acceptable to realize the operation described above in a glass beaker covered with a watch glass. Minimum sample size for analysis is defined with the prescribed working procedure.&nbsp;<h5>Storing and instruction for use:&nbsp;</h5>These CRM have to be stored in original bottle and between 5-30°C (in a dark and dry place). The materials should be analysed in the "as received" state and their dry weight should be determined on non-analysed aliquots oven-dried at 105°C till the constant weight. The material in the bottle must be rehomogenized before each use by mechanical shaking of the content for 1-2 minutes. The bottle should be opened a minimum of 2 minutes after rehomogenization in order to prevent an escape of fine powder particles from the bottle into the environment and their sedimentation.&nbsp;<h5>Certified and indicative values and their uncertainties:&nbsp;</h5>The certified and indicative values of extractable element fraction are summarized in Table 1. The overall means evaluated have been given a status of certified and indicative values using the following criteria: data should be available from at least two independent analytical methods, at least 5 and 3 accepted laboratory means should be available for calculation of the overall mean for certified and indicative value, respectively. At combined uncertainties presented, the contribution of uncertainty of characterization of a particular property value is dominant.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/ANALYTIKA_Table_1_Certified_and_indicative_values_of_contents_of_element_fractions_extractable_by_f56fa06aa5.jpg" alt="ANALYTIKA: Table 1 - Certified and indicative values of contents of element fractions extractable by aqua regia in CRM AN-ZP01 and AN-ZP02 and their associated uncertainties." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_ANALYTIKA_Table_1_Certified_and_indicative_values_of_contents_of_element_fractions_extractable_by_f56fa06aa5.jpg 187w," sizes="100vw" width="998" height="835"><h5>Chemical composition of soil matrix:&nbsp;</h5>The bulk composition of CRM AN-ZP01 and AN-ZP02 is shown in Table 2. The values presented in this table are not certified, but they may be useful for considerations concerning possible interferences while determining analytes given in Table 1, and for selection of suitable decomposition procedures if destructive analytical methods are to be used.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/ANALYTIKA_Table_2_Matrix_composition_of_CRM_AN_ZP_01_and_AN_ZP_02_of_the_oxides_dry_cd1273cf9c.jpg" alt="ANALYTIKA: Table 2 Matrix composition of CRM AN-ZP01 and AN-ZP02 (% of the oxides dry weight at 105°C)" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_ANALYTIKA_Table_2_Matrix_composition_of_CRM_AN_ZP_01_and_AN_ZP_02_of_the_oxides_dry_cd1273cf9c.jpg 170w," sizes="100vw" width="883" height="811"><h5>Note:&nbsp;</h5>Detailed information about the production, homogeneity testing and characterization of these CRM are described in the Certification report, which is available on request.

Matrix CRM of agricultural soil METRANAL® CRM AN-ZP01 and AN-ZP02

<div><div><div>Our immune system is incredibly powerful: among other things, it can recognize and destroy cancer cells. But tumors can be just as effective at avoiding detection – they build “invisibility shields” to protect themselves from attack.</div></div><div>One breakthrough in cancer therapy has been immune checkpoint inhibitors (ICIs), drugs that reactivate immune T cells and help them fight tumors again. However, only about 20–50% of patients respond well to this treatment. Researchers are therefore seeking alternative therapeutic strategies. A small and well-known molecule called adenosine plays a key role in these efforts.When tumor cells are stressed or dying, they release ATP, which is normally a signal that something is wrong in the tissue. But in the tumor microenvironment, ATP gets rapidly broken down by two enzymes, CD39 and CD73. Released adenosine acts like a chemical “calm-down” signal, binds to immune cells (T cells, NK cells, and others), and tells them to slow down, reducing their ability to kill cancer cells. Targeting CD73 therefore represents a promising strategy for developing new cancer treatments.</div><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/UOCHB_Nove_latky_mohou_podporit_imunitni_system_v_boji_s_rakovinou_88c5e82cd5.jpeg" alt="IOCB Prague: Development of potent inhibitors to boost the immune system's ability to fight cancer" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_UOCHB_Nove_latky_mohou_podporit_imunitni_system_v_boji_s_rakovinou_88c5e82cd5.jpeg 245w," sizes="100vw" width="661" height="363">At IOCB Prague, interdisciplinary teams led by Jan Řezáč, Jan Konvalinka, and Michal Hocek used a newly developed high-throughput screening method to test over 5,000 compounds, identifying two ribonucleoside derivatives as promising CD73 inhibitors.The scientists then improved the compounds’ activity by carefully modifying the ribonucleoside scaffold with bulky (het)aryl groups. Further optimization improved the pharmacokinetic properties of these compounds, yielding inhibitors with low clearance, long half-life, high solubility, and strong selectivity over related enzymes such as CD39.In cellular experiments, the compounds reduced adenosine production in cancer cells, restored T cell activation, and showed no toxicity toward human fibroblasts. The most active compound showed a single-digit picomolar inhibition constant (Ki).These findings establish a strong foundation for further in vivo efficacy and combination studies, which will explore the therapeutic potential of this novel inhibitor class.<blockquote><h4>The Original article</h4><h4><a target="_blank" rel="noopener noreferrer" href="https://pubs.acs.org/doi/10.1021/acsptsci.5c00707">Potent Competitive Inhibitors of Ecto-5′-nucleotidase (CD73) based on 6-(Het)aryl-7-deazapurine Ribonucleoside 5′-O-Bisphosphonates</a></h4>Ugnė Šinkevičiu̅tė, Magdalena Šímová, Radek Staník, Lenka Poštová Slavětínská, Kristýna Blažková, Pavel Šácha, Martin Lepšík, Jan Řezáč, Jan Konvalinka, Tereza Ormsby, Michal Tichý, Michal HocekACS Pharmacol. Transl. Sci. 2026, 9, 1, 191–213<a target="_blank" rel="noopener noreferrer" href="https://pubs.acs.org/doi/10.1021/acsptsci.5c00707">https://pubs.acs.org/doi/10.1021/acsptsci.5c00707</a><h6>licensed under <a target="_blank" rel="noopener noreferrer" href="https://creativecommons.org/licenses/by/4.0/">CC-BY 4.0</a></h6></blockquote><h4>Abstract</h4>CD73 generates immunosuppressive adenosine in the tumor microenvironment and is a promising target for cancer immunotherapy. We have designed and systematically studied diverse 2-substituted 7-deazapurine ribonucleoside 5′-O-bisphosphonates bearing a variety of (het)aryl groups at position 6 and discovered their highly potent and selective CD73 inhibition activity. The most active compounds (with single-digit picomolar Ki) contained bicyclic (het)aryl groups at position 6 in combination with chlorine at position 2. Further optimization of pharmacokinetic properties identified inhibitors with low clearance, long half-life, high solubility, and excellent selectivity over CD39 and NTPDase3. They effectively suppressed adenosine formation in MDA-MB-231 cells, rescued CD8+ T cell activation, and were nontoxic to human fibroblasts. Overall, their profile compares favorably with AB680, a CD73 inhibitor currently in phase I/II clinical trials.</div>

Development of potent inhibitors to boost the immune system's ability to fight cancer

Article

Product

Application

Scientific article

Science and research

The Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences (IOCB Prague) is a leading scientific institution in the Czech Republic, recognized internationally. Its primary mission is basic research in the fields of chemical biology and medicinal chemistry, organic and material oriented chemistry, chemistry of natural compounds, biochemistry and molecular biology, physical chemistry, theoretical chemistry, and analytical chemistry. 

Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences

Everything from the world of analytical chemistry in one place. We connect people in solving their problems. At Labrulez you will find all the necessary information easily, quickly and clearly. Stop searching and start finding.

LabRulez

Analytika is a Czech company that offers and produces certified reference materials (CRM) and (ultra)pure chemicals for quality control and quality assurance in laboratories, including accredited laboratories.

Our portfolio also includes pipettes and tips, digestors, PFA labware and other equipment for analytical laboratory and trace analysis.

ANALYTIKA

Bruker

In this webinar, participants will gain valuable insights intro Bruker’s innovation solutions tailored for the Pharmaceutical Industry. The session will commence with an introduction to Bruker, highlighting the company’s expertise and commitment to deliver cutting-edge solutions for Pharma. The webinar will then delve into FT-IR products, elucidating their applications and benefits within the pharmaceutical sector. Furthermore, attendees will explore the use of handheld Raman product, understanding how the portable device is capable to offer rapid and reliable results.&nbsp;The webinar will also shed light on FT-NIR technology, especially its role in ensuring content uniformity and facilitating Process Analytical Control (PAT) in pharmaceutical manufacturing. Lastly, the session will emphasize the compliance of Bruker products with the stringent requirements of the Pharmaceutical Industry, showcasing their adherence to quality standards and regulations.In this Webinar You Will Learn:<ul><li>FT-IR Spectroscopy for Pharma Industry</li><li>Handheld Raman Spectroscopy for QC</li><li>FT-NIR for Content Uniformity and Process Analytical Control (PAT)</li><li>Compliance to Pharma Regulations</li><li>Q&amp;A</li></ul><blockquote>Presenter: Mr. Mario EckPresenter: Dr. Felix FrommPresenter: Dr. Mui Saranwong</blockquote>

Bruker: Mastering Quality Control: The Power of FT-IR/NIR and Raman Spectroscopy for Pharmacopeia Compliance.

Mastering Quality Control: The Power of FT-IR/NIR and Raman Spectroscopy for Pharmacopeia Compliance.

In this webinar, participants will gain valuable insights intro Bruker’s innovation solutions tailored for the Pharmaceutical Industry. 

FT-IR/NIR and Raman Spectroscopy for Pharmacopeia Compliance

As we all know, the need for efficient and sustainable energy storage solutions has never been greater. With the increasing demand for electric vehicles, and storage of renewable energy, the battery industry together with academic institutes are constantly evolving and pushing the boundaries of what is possible.Bruker is at the forefront of this innovation, providing cutting-edge technologies and solutions for battery research and manufacturing. In this webinar, we will explore the latest developments in Bruker's technology and how they can be applied to optimize battery performance, reduce costs, and accelerate the path towards a cleaner energy future.Join our 75 minutes experts discussion as they dive into the fascinating world of batteries and discover how Bruker is shaping the future of it.Key Learning Topics:<ul><li>You will learn about a complete portfolio of technologies applied to battery research and production, including AFM, NMR, EPR, MS, FTIR, XRD, XRF, XRM, RAMAN, EDS and EBSD. These technologies represent the excellence of Bruker's analytical tools and are complementary in their applications. They are used in various ways to help researchers and manufacturers understand how batteries work, how they can be improved, and how they can be produced and recycled more efficiently.</li></ul>Who Should Attend?<ul><li>Battery manufacturers</li><li>Research and development organizations</li><li>Academic institutions</li><li>Material science organizations</li><li>Electrochemical and analytical chemistry organizations</li><li>Testing laboratories involved in battery research and development.</li><li>Government agencies involved in renewable energy and sustainability.</li><li>Investors interested in the battery market.</li><li>Battery technology experts and engineers</li></ul><blockquote>Presenter: Andrea Steck Ph.D. (Principal Scientist - Bruker BioSpin (Ettlingen, Germany))Andrea Steck joined BBIO Germany in 2010 to perform contract services, then stepped into food profiling development, acted as Quality Manager (ISO-17025), and now is responsible for supporting, developing, and driving AIC-DEV projects as Principal Scientist.Andrea holds a PhD in Chemistry (TU Munich). She gained extensive experience in NMR pulse sequence development and structure elucidation (Berne, Switzerland), and in leading an analytical (NMR/MS/IR) laboratory in big pharmaceutical industry (Vienna, Austria). She then joined Bruker Austria as Manager Pursuant to Trade Law, responsible for contract services and customer acquisition.Presenter: Hugues Guérault (Application Manager – Bruker Advanced X-Ray Solutions (Karlsruhe, Germany))Hugues Guérault joined Bruker in 2002 as Application Scientist. He is now leading Bruker AXS application team and manages worldwide the activities of the application laboratories for equipment demonstrations and customer training.Hugues holds a PhD in Material Science from Le Mans University (France) and made a post-doc at the University of Leuven (Belgium). Overall, he has acquired more than 25 years of experience in material characterization using X-ray diffraction.Presenter: Peter De Wolf, PhD (Sr. Director AFM Technology Development &amp; Applications, Bruker Nano Surfaces &amp; Metrology, Santa Barbara, CA, USA)Joined Bruker after obtaining Ph.D. in Electrical Engineering from the University Leuven &amp; IMEC, Belgium in 1998 focused on the development of novel AFM characterization methods. Author and co-author of over 40 publications related to property characterization using AFM, and co-inventor of several AFM methods. In his role, Peter is responsible for developing, driving, and leveraging new technology and applications for Bruker’s AFM Instrumentation.Presenter: Ph.D. Bob Galvin, FRSC (Vice President BAMS, Bruker Daltonics, London, UK)Bob Galvin obtained his PhD using mass spectrometry to investigate novel catalytic reactions and since then has always been involved in this technology. &nbsp;He joined Bruker eleven years ago and has held a number of executive positions during this period.Presenter: Rebecca Keller (Scientific Content Creator – Bruker Scientific LLC (Billerica, MA, USA))Rebecca joined Bruker Scientific in 2022 to support scientific content creation for applied markets as well as research and academia. Thanks to her extensive experience in crafting content for chemistry e-learning platforms, she excels at presenting complex ideas with exceptional clarity and precision.Rebecca graduated in Chemistry at the University of Oregon in 2019 and has since sought to improve scientific communication by producing content across multiple platforms.Presenter: Michele Gironda (Head of Global Segment Management – Bruker Nano Analytics (Berlin, Germany))Michele Gironda joined Bruker in 2017 when Bruker acquired XGLab where he was Director Sales and Marketing. He is now our Head of Global Market Segment Management in the Nano Analytics Division. In his role Michele manages worldwide activities for the key strategic market segments in cooperation with sales, marketing, application and product managers.Michele holds a Master Degree in Engineering obtained with his studies in Politecnico di Milano (Italy) and Universitat Politecnica de la Catalunya in Barcelona (Spain).</blockquote>

Bruker: Shaping the future of batteries: Bruker technologies across the entire value chain

Shaping the future of batteries: Bruker technologies across the entire value chain

Join our 75 minutes experts discussion as they dive into the fascinating world of batteries and discover how Bruker is shaping the future of it.

Bruker technologies - Shaping future of batteries

Electron paramagnetic resonance (EPR) spectroscopy is an innovative tool to detect free radicals in skin and blood plasma. It is a powerful technique that can help us learn more about the redox status, and induced oxidative stress by quantification and characterization of different types of radicals formed in the skin, skin models, skin cells, and blood plasma.In skin, a critical radical concentration characterized by the reversal of primary ROS (reactive oxygen species) to secondary LOS (lipid oxygen species), leading to increased lipid peroxidation and consequent cellular damage is known. This reversal indicates a change in the redox balance. EPR spectroscopy represents an innovative sensitive tool to assess the antioxidant status by stress response methods in skin and blood plasma. The redox status and oxidative stress investigations were performed in blood plasma samples, and in ex vivo and in vivo skin. These permit evaluating antioxidative supplements and formulations but also studying the influence of oxidative stress, which could be induced by irradiation, lifestyle, or pollution. Cigarette smoke is a good representative of pollution and it is known that it affects the whole body and can induce skin aging. These effects could be shown using EPR spectroscopy but also other methods such as cytokine analysis, resonant Raman spectroscopy, and biochemical assays. New insights about direct smoking and passive smoking will be presented.Key Learning Topics:<ul><li>EPR as a tool to measure reactive oxygen and lipid oxygen species in skin</li><li>Detecting radicals ex vivo and in vivo in skin using spin probes and spin traps</li><li>Examples of redox status and oxidative stress in skin and plasma using EPR</li></ul>Who Should Attend?<ul><li>Academics and MDs who do any kind of skin and blood plasma research</li><li>General, R&amp;D and Qc/QA managers, and industrial customers from the health and personal care industries involved in development of skin care products</li></ul><blockquote>Presenter: Prof. Dr. Martina Meinke (Head of the Center of Experimental and Applied Cutaneous Physiology (CCP), Charité – Universitätsmedizin Berlin)Prof. Martina. C. Meinke is Head of the Center of Experimental and Applied Cutaneous Physiology (CCP) at the Clinic for Dermatology, Venerology and Allergology. Prof. Meinke studied chemistry at the Free University of Berlin, Germany. After graduation she headed an environmental laboratory until she switched to medical diagnostics. Since 1999, she has been employed by the CCP. After a postgraduate study, she was awarded the title medical physicist in 2006. Since 2007, she is an Assistant Professor of medical physics with the main focus on spectroscopy of blood and skin and electron paramagnetic resonance measurements in skin. She has headed the EPR (electron paramagnetic resonance) spectroscopy group for over 10 years. This method has already been used in several clinical and scientific studies to investigate the formation and characterization of radicals. She also focuses on optical, non-invasive techniques that are widely used for skin examinations.Prof. Meinke is author of more than 200 peer reviewed publications and numerous book chapters. She is a member of the Ethics Committee of the Charité and a reviewer for the BMBF VIP+ and the DFG.Presenter:&nbsp;Dr. Silke Lohan (Deputy Head of the Center of Experimental and Applied Cutaneous Physiology (CCP), Charité – Universitätsmedizin Berlin)Dr. Silke Lohan was born in Berlin and studied biology at the Free University of Berlin. In 2013, she completed her dissertation (Dr. rer. nat.) in human genetics. She had done her doctoral thesis at the Institute of Medical Genetics and Human Genetics at Charité - Universitätsmedizin Berlin and at the Max Planck Institute for Molecular Genetics. In October 2013, Dr. Lohan joined the team at CCP. Her main interest is electron paramagnetic resonance spectroscopy (EPR), which she applies in vivo, ex vivo and in vitro to study and assess the evolution of radicals in tissues and cells with and/or without the application of stressors. The radicals can be quantified and characterized. In addition, nanoparticle penetration and drug release processes in skin can be studied.Currently, she is focusing on projects related to the development and clinical application of UV-LEDs. Here, the focus is on the development of a method to determine the redox status in skin and blood. In addition, a measurement method is being established to investigate the effect of pollutants and the protective effect of anti-pollutant products on the skin.Presenter:&nbsp;Dr. Sylwia Kacprzak (Market Product Manager)Sylwia Kacprzak received her M.Sc. degree in Chemistry at the University of Maria Curie Sklodowska in Poland. Her EPR career began during her Ph. D. research at the University of Würzburg with a focus on investigations of the electron paramagnetic resonance parameters of bioradicals by density functional methods. Two postdoctoral positions followed at FU Berlin and University of Freiburg, where she gained extensive expertise in CW-EPR and FT-EPR techniques taking advantage of her theoretical background. In 2016, Sylwia joined Bruker as an Applications Scientist.</blockquote>

Bruker: Redox Status of Skin and Blood Measured by EPR Spectroscopy

Redox Status of Skin and Blood Measured by EPR Spectroscopy

In this webinar you will learn about EPR which is as a tool to measure reactive oxygen and lipid oxygen species in skin.

Metal-ion batteries have changed our everyday lives. The research on the electrode materials for metal-ion batteries is the key to improving the performance of the battery. Magnetic resonance, including nuclear magnetic resonance (NMR) and electron paramagnetic resonance (EPR), has been continuously improved during the past three decades and has gradually become one of the important technologies to study the structure-performance relationship of electrode materials.This webinar will help to grasp the important value of NMR and EPR techniques for battery research, which will promote the further development of advanced magnetic resonance technology. Prof. Hu will present unique examples of in-situ EPR and EPR imaging methods to study bulk and dendritic lithium deposits, dissolution of Cr-ions in Na-batteries, detection, and monitoring oxygen species, such as molecular and singlet oxygen in new cathode materials. A novel approach of using EPR employed together with NMR to analyze and understand electrochemical reaction mechanisms and structural electrode changes is the key to further improving battery performance.Key Learning Points:<ul><li>In-situ EPR and EPR imaging to study electrode materials in Li-ion and other types of batteries</li><li>Development of new electrode materials or optimization of available electrode materials that can work at high cell voltage and high specific capacity as a major task in the field</li><li>The importance of EPR and NMR techniques complementing each other for battery research &nbsp;</li></ul>Who Should Attend?<ul><li>Material scientists who use other spectroscopic techniques such as NMR, Raman, MS, XRD, etc.</li><li>Synthetic chemists working in inorganic chemistry</li><li>Managers, apps scientists, electrochemists who work in the battery research field</li></ul><blockquote>Presenter: Prof. Bing-Wen Hu (Shanghai Key Laboratory of Magnetic Resonance, East China Normal University)Prof. Hu studied at Fudan University from 1999 to 2006, and from 2006 to 2009 at the French Ultra high-Field Nuclear Magnetic Resonance Research Center at the University of Lille, France, where he was engaged in the development of new NMR methods. After his return to China, he focuses on the development of new technologies for NMR and EPR and their application in lithium-ion and sodium-ion battery systems. He has published more than 150 articles. He was a recipient of YuanZhi EPR (CHINA) award in 2022. He is currently the deputy director of the Shanghai Key Laboratory of Magnetic Resonance. He now holds a position of Full Professor at East China Normal University.Presenter:&nbsp;Dr. Sylwia Kacprzak (Market Product Manager)Sylwia Kacprzak received her M.Sc. degree in Chemistry at the University of Maria Curie Sklodowska in Poland. Her EPR career began during her Ph. D. research at the University of Würzburg with a focus on investigations of the electron paramagnetic resonance parameters of bioradicals by density functional methods. Two postdoctoral positions followed at FU Berlin and University of Freiburg, where she gained extensive expertise in CW-EPR and FT-EPR techniques taking advantage of her theoretical background. In 2016, Sylwia joined Bruker as an Applications Scientist.</blockquote>

Bruker: Magnetic Resonance for Li-ion Batteries: from NMR to EPR

Magnetic Resonance for Li-ion Batteries: from NMR to EPR

This webinar will help to grasp important value of NMR and EPR techniques for battery research

FT-IR spectroscopy is an easy-to-use and nondestructive analysis tool for chemical identification, quantification, composition analysis, optical characterization and many more. Depending on measurement geometry (beside transmission measurement) and optical properties of sample materials FT-IR can be very surface sensitive. It provides plenty of surface analysis techniques with different penetration depth to qualitatively or quantitatively characterize the upper layer of a sample, to follow surface reactions or to observe surface emissions etc. Depending on sample form, e.g. powder, gel, liquid, crystal blocks, coatings, micro sized samples or else, different FT-IR techniques can be applied.In this Webinar You Will Learn:<ul><li>Attenuated Total Reflection - ATR</li><li>Diffuse Reflectance Infrared Fourier Transform Spectroscopy - DRIFT</li><li>Specular Reflectance</li><li>InfraRed Reflection Absorption Spectroscopy - IRRAS</li><li>Emission Spectroscopy</li><li>Photo Acoustic Spectroscopy - PAS</li></ul>Who Should Attend?<ul><li>Surface analysis experts (e.g. material science, polymers, automotive…)</li><li>Spectroscopy experts (e.g. academia, physicists, chemists…)</li><li>Microscopy experts (e.g. research, pharmaceuticals, electronics… )</li></ul><blockquote>Presenter: Dr. Xia StammerDr. Xia Stammer studied Physical Chemistry and focused on surface functionalization and characterization during her PhD and research activities. She has been FT-IR application specialist since almost 10 years at Bruker and is specialized for FT-IR research solutions for catalysis, material science and surface analysis.Presenter:&nbsp;Dr. Inga Köhler&nbsp;Dr. Inga Köhler studied Geology and Paleontology and acquired her PhD with focus on Early Earth. Inga has a strong interest in communicating scientific topics to the public and continues to contribute to Archean research. At Bruker, she works as a Scientific Content Creator for FT-IR and Raman spectroscopy as well as microscopy.</blockquote>

Bruker: Shed Light on Surface | How to use FT-IR to characterize surfaces  

Shed Light on Surface | How to use FT-IR to characterize surfaces

In this webinar, you will learn about various FT-IR techniques for surface characterization.

How to use FT-IR to characterize surfaces  

In this webinar we will show you:<ul><li>Why FT-IR is the method of choice for particle-driven analysis of microplastics.</li><li>Demands and requirements to establish a microplastic lab based on FT-IR technology.</li><li>Necessary steps in sample preparation from various sources.</li><li>Theoretical basics to understand the idea behind FT-IR analysis of microparticles.</li><li>That there are comprehensive, complete solutions to microplastic analysis, right out of the box.</li></ul>You will learn about:<ul><li>Instrumental setup and experimentals</li><li>Particle analysis and evaluation</li><li>Microplastic software solutions</li></ul>We will cover the basics of:<ul><li>Different microplastics analysis techniques</li><li>Sample types</li><li>Sample preparation steps</li><li>FT-IR experimental procedures</li><li>FT-IR instrumentation</li></ul>Who should attend:<ul><li>Analytical service laboratories</li><li>Environmental researchers</li><li>Food &amp; Feed producers</li><li>Drinks &amp; Beverages producers</li></ul>FT-IR and Raman are very versatile analytical techniques - but did you know that Bruker offers by far the most comprehensive product range for spectroscopy? Our instruments cover all applications from routine incoming inspection, to multispectral fundamental research at the highest level, to solutions for in-process monitoring.If you are looking for new and innovative solutions to your analytical problems, we welcome you to join our free webinars on spectroscopic measurement techniques, perhaps making your daily work easier.Your Bruker Optics Team

Bruker: Why FT-IR FPA Imaging is King in Microplastics Analysis?

Why FT-IR FPA Imaging is King in Microplastics Analysis?

In this webinar we will show you why FT-IR is the method of choice for particle-driven analysis of microplastics.

Once again, we point out the strong synergies of pharmaceutical research, process development and quality control with Raman microscopy. In this webinar, our Raman expert Di Yan will first highlight the basics and then analyze three typical samples. For this, we leave the "PowerPoint monotony" and go hands-on with the Raman microscope. Afterwards there will be a live question and answer session to answer your questions.You will learn about:<ul><li>How to apply Raman microscopy</li><li>What to look out for in Raman instrumentation</li><li>How to comply with regulations using a Raman microscope</li></ul>What is the goal of the webinar:<ul><li>Demonstrate the utility of Raman microscopy in Pharma</li><li>Highlight the unique benefits of Raman microscopy</li></ul>We will discuss:<ul><li>Relationships between Raman and other techniques (e.g. XRD)</li><li>Basics of Raman microscopy and imaging</li><li>Application example #1: API distribution</li><li>Application example #2: Polymorphism</li><li>Application example #3: Particle analysis</li></ul>Who should attend:<ul><li>R&amp;D specialists, especially process developers</li><li>Quality control and PAT specialists</li><li>Planning to buy Raman microscope</li><li>Thinking about implementing Raman microscopy</li><li>Want to learn more about Raman microscopy in Pharma</li></ul><blockquote>Presenter: Dr. Di YanDr. Di Yan is a product manager at Bruker for Raman microscopy. He has studied physical chemistry at Friedrich Schiller University and Leibniz Institute of Photonic Technology and has extensive experience in Raman detection techniques.</blockquote>

Bruker: Tools for Pharmaceutical Troubleshooting: Raman Microscopy

Tools for Pharmaceutical Troubleshooting: Raman Microscopy

In this webinar, our Raman expert Di Yan will first highlight the basics and then analyze three typical samples.

By combining infrared spectroscopy with atomic force microscopy (AFM-IR), it is possible to perform chemical analysis and compositional mapping with a spatial resolution down to 10 nm, which greatly surpasses standard optical diffraction limits. During this 2-hour event, our speakers explore:<ul><li>Origins of the AFM-IR technique</li><li>Recent advances in AFM-IR technology</li><li>Applications that can benefit from AFM-IR spectroscopy—especially life sciences and environmental chemistry</li></ul>Bruker Application Scientist Dr. Cassandra Phillips hosts the workshop and live demos, providing an overview of Bruker's latest nanoIR product updates.&nbsp;Watch this webinar to:<ul><li>Hear distinguished guest speakers discuss their work on AFM-IR with the nano-IR platform</li><li>Experience Bruker's new patented Surface Sensitive mode</li><li>Become familiar with Bruker's new AFM-IR platforms</li></ul><blockquote>Presenter: Xiaoji Xu, Ph.D.Presentation: NanoIR through PeakForce Infrared (PFIR) MicroscopyHere, Xiaoji Xu, Ph.D. (Lehigh University) introduces the novel PFIR method of AFM-IR developed at Lehigh University. This method of label-free chemical nanoscopy is based on the mechanical detection of photothermal response by AFM operated in PeakForce Tapping mode and ultimately can achieve a higher spatial resolution (sub-10 nm) and provide more rich chemical information than many of the existing tools we use for chemical imaging—or imaging in general—while also providing greater flexibility in applicability to samples in both air and liquid.In addition to providing a review of the strengths and benefits of PFIR as they relate to foundational AFM-IR and PeakForce Tapping principles and capabilities, the presentater explores and provides detailed, real-world examples of PFIR's applicability to a broad range of sample types and experimental settings.Presenter: Dmitry Kurouski, Ph.D.Presentation: Biology at the Nanoscale: From Viruses to AmyloidsIn this presentation, Dmitry Kurouski, Ph.D. (Texas A&amp;M University) showcases his team's research and findings using TERS and AFM-IR to investigate viruses, viral particles, and alpha-synuclein oligomers. Topics of this discussion range from an exploration of how IR/AFMIR spectroscopy reveals a variety of infrared spectra in biological samples that are otherwise inaccessible by traditional Raman microscopy methods, to a detailed presentation of the team's findings via a combination of AFM-IR and TERS about changes observed in the secondary structural organization and surface structure information of populations of oligomers relative to their impact on the development of Parkinson's disease.These two technologies possess different capabilities that demonstrate strong complementarity in terms of both the chemical information available and the achievable probing depth.Presenter: Cassandra Philips, Ph.D.Presentation: Quantitative Demonstration of Surface Sensitivity with nanoIR3The presenter conducts a profile analysis of a PMMA wedge sample in both Resonance enhanced and Surface Sensitivity modes, then demonstrate the analytical process for data collected in Surface Sensitivity mode.Comparison of the data outputs of various operational modes demonstrates that using the same probe and sample, users can switch from looking at bulk measurements (where the signal increases linearly with the thickness) to measurements with a surface sensitivity on the order of 15 nm just by adjusting the parameters.Surface Sensitivity mode enables measurement of the top layer of a sample with significantly improved accuracy over other operational modes, as it collects data only from the surface and not from the absorbing material beneath it.&nbsp;Presentation: Demonstration: New Platforms for AFM-IRThe presenter introduces the unique capabilities of a new Bruker platform for AFM-IR imaging.Looking at a sample of PMMA beads in epoxy resin, the presenter demonstrates the new platform's capability to achieve higher acuity and operate at higher scan speeds than other nanoIR systems. Its integration with both Bruker's most advanced AFM controller and legacy Tapping Mode imaging capabilities are explored.Additionally, the presenter showcases the ability to switch wavenumber and reconfigure laser power mid-scan (to look at both the epoxy band and the carbonyl band of the sample), as well as the platform's unique capacity to switch between sample-scanning and tip-scanning configurations, enabling investigation of the chemical composition and mechanical properties of the same sample using the same probe.</blockquote>

Bruker: NanoIR Spectroscopy & Imaging: Recent Developments and Applications

NanoIR Spectroscopy & Imaging: Recent Developments and Applications

Find out more about Bruker's latest nano IR product updates and see real-time demonstrations of the new Surface Sensitive mode and new AFM-IR platforms

NanoIR Spectroscopy & Imaging - Developments & Applications

We collected real-life applications of particle analysis in pharmaceutical manufacturing and quality control and present them in this brief 20 minute webinar.Learn about the differences of FT-IR and Raman microscopy in particle analysis and which technique is the best for a specific scenario.

Bruker: Root Cause, Particle and Failure Analysis in Pharmaceutical Industries

Root Cause, Particle and Failure Analysis in Pharmaceutical Industries

Learn about the differences of FT-IR and Raman microscopy in particle analysis and which technique is the best for a specific scenario.

Particle Analysis in Pharmaceutical Industries

Biogen is among the first biopharmaceutical companies to employ PAT in an active role in the manufacturing of biologicals. The implementation of in-process Raman for glucose control, biocapacitance for in-line cell growth monitoring as well as in-line refractive index and other univariate techniques for the automatic in-line release of process solutions is being discussed. GMP-specific considerations such as risk assessment, data integrity and qualification strategy are presented as well.The application of PAT in an active role as part of the control strategy in commercial production in a cGMP compliant environment is not yet done very frequently in the biopharmaceutical industry. This is due to a combination of risk factors which typically involve regulatory challenges, technology maturity and economic benefit. Biogen decided to employ PAT at large scale mammalian cell culture at its new manufacturing site at Solothurn, Switzerland. Biogen’s Aducanumab process has shown to benefit significantly from direct PAT control. Inline Raman spectroscopy and inline biocapacitance are used to actively control the feed of glucose and nutrients to the production bioreactor. The glucose concentration is predicted using a validated PLS model and is used as input for a closed loop control device that is controlling the addition of glucose solution to the bioreactor in a virtually continuous manner.<blockquote>Presenter: Oliver Steinhof (Global Lead PAT, Biogen)Supporting the Digital Development and Analytics team at Biogen since 2017 with a focus on PAT implementation and commercialization. Focus over the last 4 years was the startup of Biogen’s Next Generation Manufacturing facility at Solothurn Switzerland. Since 2015 at Lonza Visp, Switzerland, leading the PAT laboratory and providing PAT consulting and solutions to the global Lonza network, including small molecule API manufacture and chemicals. Since 2009 several roles at Shell Global Solutions in Hamburg Germany around lubricants R&amp;D, including management of the analytical services team, global technical support manager, internal consultant, quality auditor and project leader for R&amp;D projects. Chemist by training, spending time at the Universities of Braunschweig Germany, Salt Lake City Utah and Tuscaloosa Alabama. PhD in industrial chemistry sponsored by BASF SE with a focus on on-line NMR spectroscopy and reaction engineering of complex polycondensations.Presenter: Martin Gadsby (Owner and Director, Optimal Industrial Automation)Martin graduated from the University of Bath in the late 1970’s, and after working through a few positions in industry, he became the European R&amp;D Process and Process Automation Group Leader for Kraft Foods. &nbsp;After a few years at Kraft, Martin decided to set up a process automation business with a colleague, Dave Richards, and Optimal was born. Optimal Industrial Automation was formed over 33 years ago, with Martin now being the Vice President of Optimal Industrial Technologies which was formed more recently as the products division and is the market leader in the field of Process Analytical Technology (PAT) with its PAT Knowledge Management product – synTQ. &nbsp;Martin is intimately involved with progressing the evolution of synTQ and advising the Optimal development team on what he believes to be the optimum development direction. &nbsp;Over the last few years, he has taken on the overall responsibility not only for the company but also for the sales and marketing of synTQ whilst remaining very active in ensuring that the development of synTQ continues unabated. &nbsp;On the personal front, Martin is a bit of a ‘petrol head’ and enjoys flying aerobatics and racing cars.</blockquote>

Bruker: Next Generation Manufacturing at Biogen – PAT as an Enabler for Enhanced Process

Next Generation Manufacturing at Biogen – PAT as an Enabler for Enhanced Process

In this webinar, the implementation of in-process Raman for glucose control is being discussed.