Our Library never stops expanding. What are the most recent contributions to LabRulezICPMS Library in the week of 6th April 2026? Check out new documents from the field of spectroscopy/spectrometry and related techniques!<blockquote>👉 <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/library">SEARCH THE LARGEST REPOSITORY OF DOCUMENTS ABOUT SPECTROSCOPY/SPECTROMETRY RELATED TECHNIQUES</a></blockquote><blockquote>👉 Need info about different analytical techniques? Peek into <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/library">LabRulezLCMS</a> or <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library">LabRulezGCMS</a> libraries.</blockquote>This week we bring you application notes by Metrohm, Shimadzu, Thermo Fisher Scientific and Waters Corporation!<h3>1. Metrohm: Whey permeate analysis with NIRS</h3>Monitor dairy production processes easily in seconds<ul><li>Application note</li><li><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/labrulez-bucket-strapi-h3hsga3/an_nir_144_download_34598659f1.pdf">Full PDF for download</a></li></ul>Whey permeate, a byproduct of manufacturing whey protein powder, contains high amounts of lactose, phosphate, and minerals. Because of its sweet and mild taste, whey permeate is often used in bakeries and chocolate manufacturing. The key to optimizing whey permeate production is to control production streams in real time. It is important to monitor the production process with highthroughput analytical techniques to maximize product yield and ensure high product quality.&nbsp;Nearinfrared spectroscopy (NIRS) is a fast, and chemicalfree analysis technique that can support this kind of testing. NIR spectroscopy can measure the most important quality parameters (i.e., protein, lactose, moisture, ash, pH, and phosphate) simultaneously in whey permeate without any sample preparation. The NIRS solution is fast, easy to operate, and can be used atline or offline in a quality control lab.<h4>EXPERIMENTAL EQUIPMENT&nbsp;</h4>158 whey permeate samples were analyzed on a <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/library?mainauthorItems=220&amp;search=NIR+analyzer">Metrohm NIR Analyzer</a> equipped with a small cup accessory. All measurements were performed in reflection mode (1000–2250 nm). Metrohm software was used for data acquisition and prediction model development.<h4>CONCLUSION&nbsp;</h4>This Application Note demonstrates the feasibility of using NIR spectroscopy for whey permeate quality control. Near infrared-spectroscopy is a rapid, nondestructive analytical technique that can monitor the production process of dairy products. Aside from the analysis of whey permeate, the whey protein production stream can also be monitored by NIRS.<h3>2. Shimadzu: Measurement of Residual Metal Catalysts by X-ray Fluorescence</h3><ul><li>Application note</li><li><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/labrulez-bucket-strapi-h3hsga3/an_01_01086_en_4beb25fd1d.pdf">Full PDF for download</a></li></ul><h4>User Benefits</h4><ul><li><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/library?mainauthorItems=1&amp;search=ALTRACE">ALTRACE</a> can determine levels of heavy metals present in organic compounds at around 1 mg/kg in under 10 minutes per sample.</li><li>Analyzing and managing levels of residual metal catalysts can be performed by simply placing samples in the sample vessel and analyzing them without the need for complex sample pretreatment.</li><li>By increasing the X-ray tube power and optimizing the optical design, the sensitivity of ALTRACE for heavy metals has been dramatically improved compared to the previous model.</li></ul>Many industrial products we encounter every day are produced from organic compounds by manufacturing processes that utilize a range ofsynthesisreactions and metal catalysts. Catalysis can be classified as either homogeneous or heterogeneous (although drug and chemical production processes typically use homogeneous catalytic systems). While homogeneous catalysis allows for precise control over catalytic reactions, recovering the catalyst after the reaction can be difficult.&nbsp;Nevertheless, managing the levels of residual catalysts in industrial products is critical to ensure safety and because of their high costs. For example, the ICH Q3D Guideline for Elemental Impurities (adopted in April 2017) requires risk assessments when materials such as metal catalysts are added intentionally during a production process.&nbsp;Energy dispersive X-ray fluorescence (EDXRF) spectrometry offers a simple but effective technique for assessing the levels of residual metal catalysts. Normally, the lower limit of quantification for EDXRF spectrometric analysis of heavy metals is above 1 mg/kg, which limitsits use in quantitative analysis. However, the <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/library?mainauthorItems=1&amp;search=ALTRACE">ALTRACE</a> is equipped with a high-power X-ray tube that dramatically improves its sensitivity for heavy metals, enabling their determination at 1 mg/kg and below in lessthan 10 minutes. This Application News describes using ALTRACE to determine residual levels of a homogeneous catalyst after a synthesis reaction. The catalyst used in this analysis is palladium (Pd), which is a widely applied heavy metal catalyst, and the reaction catalyzed by the Pd catalyst is a cross-coupling reaction. A metal scavenger and activated carbon were each used to remove the Pd catalyst from the reaction products. Metal scavengers are frequently used in this role, and activated carbon offers a relatively cheap method for removing catalysts.<h4>Conclusion&nbsp;</h4>Common methods of elemental impurity analysis, such as atomic absorption spectrometry (AAS), ICP atomic emission spectroscopy (ICP-AES), and ICP mass spectrometry (ICP-MS), require liquid samples, so solid and powder samples must be prepared into a solution prior to analysis. However, EDXRF spectrometry can determine levels of elemental impurities regardless of the sample phase or form (solution, powder, etc.), provided the target element is distributed uniformly throughout the sample. The sensitivity of ALTRACE for heavy metals has been substantially improved compared to previous models, allowing for rapid quantitative determination of heavy metals at 1 mg/kg and below. Based on the performance presented in this article, ALTRACE is an effective tool for managing residual levels of metal catalysts.<h3>3. Thermo Fisher Scientific: The Raman Spectroscopy of Graphene and the Determination of Layer Thickness</h3><ul><li>Application note</li><li><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/labrulez-bucket-strapi-h3hsga3/raman_spectroscopy_graphene_determination_layer_thickness_an52252_29274e8aea.pdf">Full PDF for download</a></li></ul>Currently, a tremendous amount of study is being directed toward graphene. This interest is driven by the novel properties that graphene possesses and its potential use in a variety of application areas that include but are not limited to electronics, heat transfer, bio-sensing, membrane technology, battery technology and advanced composites. Graphene exists as a transparent two-dimensional network of carbon atoms. It can exist as a single atomic-layer thick material, or it can be readily stacked to form stable, moderately thick samples containing millions of layers—a form generally referred to as graphite. However, the interesting properties exhibited by graphene (substantial electrical and thermal conductivity, high mechanical strength, and high optical transparency) are only observed for graphene films that contain only one or a few layers. Therefore, developing technologies and devices based upon graphene’s unusual properties requires accurate determination of the layer thickness for materials under investigation. Raman spectroscopy can be employed to provide a fast, non-destructive means of determining layer thickness for graphene thin films.<h4>Instrument considerations&nbsp;</h4>There are a few specifications that should be considered when selecting a Raman instrument for graphene characterization. First, since graphene samples are usually very small, selecting a Raman instrument with microscopy capabilities is imperative.The next issue to consider is which excitation laser to select. While graphene measurements can be made successfully with any of the readily available Raman lasers, it is also important to consider the substrate that the graphene will be deposited onto. It is common for graphene to be deposited on on either Si or SiO2 substrates, and both of these materials can exhibit fluorescence with near-infrared (NIR) lasers such as 780 nm or 785 nm. For this reason, visible lasers are usually recommended, typically a 633 nm or 532 nm laser.&nbsp;Next, since relatively small wavenumber shifts can significantly impact the interpretation of the Raman spectra, it is crucial to have a robust wavelength calibration across the entire spectrum. Using a single point wavelength calibration with some other applications may be sufficient, but this only ensures that one wavelength is calibrated and leaves room for a large margin of error. A multipoint wavelength calibration that is regularly refreshed, such as the standard calibration routine used with <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/products?category=184&amp;manufacturerItems=3&amp;search=dxr3">Thermo Scientific DXR3 Raman instruments</a>, will provide considerably more confidence in the results. It is also necessary to have an instrument with high wavenumber precision to observe small wavenumber shifts when altering the sample. In fact, small wavenumber shifts can represent changes in the sample rather than represent the variability from the instrument. There is a common myth that it is necessary to utilize high resolution in order to achieve high wavenumber precision. Not only is this incorrect, but a high resolution will actually add considerable noise to the spectrum, which will add to the wavenumber variability. A high degree of wavenumber precision, such as that provided by the <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/products/2239">Thermo Scientific™ DXR™3 Raman Microscope</a>, will significantly improve data confidence even when you are evaluating band shifts from low levels of strain or doping. It is also important to have exact control of your laser power at the sample and be able to adjust that laser power in small increments. This is important to control temperature-related effects and to provide flexibility to maximize Raman signal while still avoiding sample heating or damage from the laser. The DXR3 Raman systems are equipped with a unique device called a laser power regulator, which maintains laser power with unprecedented accuracy and provides exceptional ability to fine-tune laser power and optimize it for each experiment.1&nbsp;Lastly, the Raman microscope must have an automated stage and associated software to generate detailed Raman point maps. As will be seen in the next section, Raman point mapping or imaging extends the single point measurement to assess a sample’s layer thickness uniformity. The Thermo Scientific OMNIC™ Software suite contains powerful mapping and processing tools that diminish the complexity of collecting highly detailed maps and interpreting their results.<h4>Conclusions&nbsp;</h4>Raman spectroscopy is an excellent tool for the characterization of graphene and layer thickness. Few techniques will provide as much information about the structure of graphene samples as Raman spectroscopy, and any lab doing graphene characterization without Raman would be at a significant disadvantage. The DXR3 Raman Microscope is an ideal Raman instrument for graphene characterization because it can provide the high level of stability, control, and sensitivity needed to produce confident results.<h3>4. Waters Corporation: See What’s Really in Your Formulation with Backgrounded Membrane Imaging</h3><ul><li>Application note</li><li><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/labrulez-bucket-strapi-h3hsga3/720009098_en_5d36d71789.pdf">Full PDF for download</a></li></ul>Protein aggregation in therapeutic protein products can induce adverse immunogenic responses in patients1–4 . Per the FDA’s recommendations, “strategies to minimize aggregate formation should be developed as early as feasible in product development”5 and “an assessment should be made of the range and levels of subvisible particles (2–10 µm) present in therapeutic protein products initially and over the course of the shelf life”.5 Yet, accurate subvisible protein aggregation analysis has remained elusive to protein drug formulators since current subvisible analyzers are not sensitive enough to measure protein aggregates effectively. In this application note, we explore how backgrounded membrane imaging (BMI), a high refractive index contrast technique used by the HORIZON particle analysis system, performs highly sensitive measurements of subvisible protein aggregates in the 2 µm–4 mm size range, enabling 30% higher reproducibility compared to flow imaging.<h4>Conclusion&nbsp;</h4>When studying the impact of protein aggregate refractive index, IgG protein aggregates analyzed on both the <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/library?mainauthorItems=5&amp;search=HORIZON">HORIZON® instrument</a> and flow imager systems produced equivalent particle count trends. However, the HORIZON® system was more sensitive (measured more overall counts) and had overall lower variability with average CVs of 14.4% compared to the flow imager which produced average CVs of 20.1%. The differences in variability and counts were most pronounced at lower concentrations and size range respectively. Given that most particles in a therapeutic drug formulation are small, the inability of flow imagers to accurately count the smallest of protein aggregates has a dramatic impact on the total number of particles measured. This can mean an undercounting by as much as 3–10X depending on the protein and formulation conditions.&nbsp;High variability at low concentrations in flow imagers can pose a hurdle for early stage analysis were sample is scarce. In low volume analysis (&lt;250 µL), the possibility of measuring fewer particles increases, therefore it is imperative to have high sensitivity measurements when already challenged by low sampling statistics.&nbsp;In the excipient effect study, sucrose did not have an impact on the overall particle counts when measured using the HORIZON® system. This contrasts with previous studies comparing excipient effects on three flow imagers.10 In each case, the particle counts decreased up to 30% or more using standard sucrose formulation concentrations of 0–20%. The difference between the data generated by BMI and FI can be attributed to the fact that the HORIZON® instrument is not affected by particle or solution refractive index.&nbsp;Flow imagers are deeply vulnerable to the impact of refractive index when measuring protein aggregates due to their translucency and the negative impact of surfactants. Due to this basic optical phenomenon, flow imagers can dramatically undersize and undercount particles. Finding the right tool for the job will have a critical impact on data accuracy and sensitivity. Powered with BMI, the HORIZON® system provides high refractive index contrast analysis to enable accurate, robust, and sensitive subvisible particle counting from 2 µm–4 mm in as little as 25 µL of sample and 96 samples in under 2 hours.

News from LabRulezICPMS Library - Week 15, 2026

The set of soils consist of two natural agricultural soils differing in elemental composition&nbsp;<ul><li>AN-ZP01: Heavy loam with normal analyte levels&nbsp;</li><li>AN-ZP02: Silty clay loam contaminated with some heavy metals&nbsp;</li></ul>Contents of element extractable fractions with aqua regia according to ISO 11466&nbsp;<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/ANALYTIKA_agricultural_soil_CRM_0534e68e65.jpg" alt="ANALYTIKA: Matrix CRM of agricultural soil METRANAL® CRM AN-ZP01 and AN-ZP02" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_ANALYTIKA_agricultural_soil_CRM_0534e68e65.jpg 156w," sizes="100vw" width="827" height="827"><h5>Packing:&nbsp;</h5><ul><li>50 g of powder of the respective soil with a particle size of less than 100 µm in amber glass bottle.&nbsp;</li></ul><h5>Intended use:&nbsp;</h5>This set of certified reference materials is intended primarily for use in realizing metrological traceability, validation of analytical methods and the transfer of property values to other materials of similar composition.&nbsp;<h5>Recommended analytical methods for method dependent measurements:</h5><ul><li>Flame AAS, ETA-AAS, ICP-OES, ICP-MS, AMA-254&nbsp;</li></ul><h5>Metrological traceability:&nbsp;</h5>Metrological traceability is realized by using certified calibration standards solutions for the calibration of measurement methods used (direct traceability to SI unit) and/or by simultaneous analysis of a matrix CRM (RM) of similar composition.<h5>Sample preparation (aqua regia extract according to ISO 11466):&nbsp;</h5>Weigh a 3 g (± 0.001 g) sample into a 100 ml round bottom flask. Add a small amount of water (2 to 3 ml) to obtain a slurry, then 7.5 ml of conc. HNO3 (density 1.40 g/ml). Let the mixture stand until intensive foaming ceases, then add (in several portions) 22.5 ml of conc. HCl (density 1.19 g/ml), shake the mixture manually, cover the flask with a watch glass, and let stand for 16 hours (overnight) at the laboratory temperature (20 ± 2°C). Then mount a reflux condenser (a Dimroth type or similar) of about 40 cm length on the top of the flask and boil gently under reflux for 2 hours. After cooling, rinse the condenser with 20 ml of warm (~ 50°C) dilute nitric acid (5%, v/v), the liquid being collected in the round bottom flask. Remove the condenser and filter the solution from the flask through an acid-resistant high density paper filter and collect it in a 100 ml volumetric flask (make sure in preliminary tests that a suitable filter was chosen, so that the filtrate is clear). Rinse the filter and the residue three times with 5 ml of warm (~ 50°C) dilute nitric acid (5%, v/v); allow to cool and dilute with nitric acid 5% (v/v) to the mark. Transfer immediately the solution from the volumetric flask into a clean, dry 100 ml polyethylene bottle. Realize three blanks using exactly the same analytical procedure.&nbsp;It is acceptable to realize the operation described above in a glass beaker covered with a watch glass. Minimum sample size for analysis is defined with the prescribed working procedure.&nbsp;<h5>Storing and instruction for use:&nbsp;</h5>These CRM have to be stored in original bottle and between 5-30°C (in a dark and dry place). The materials should be analysed in the "as received" state and their dry weight should be determined on non-analysed aliquots oven-dried at 105°C till the constant weight. The material in the bottle must be rehomogenized before each use by mechanical shaking of the content for 1-2 minutes. The bottle should be opened a minimum of 2 minutes after rehomogenization in order to prevent an escape of fine powder particles from the bottle into the environment and their sedimentation.&nbsp;<h5>Certified and indicative values and their uncertainties:&nbsp;</h5>The certified and indicative values of extractable element fraction are summarized in Table 1. The overall means evaluated have been given a status of certified and indicative values using the following criteria: data should be available from at least two independent analytical methods, at least 5 and 3 accepted laboratory means should be available for calculation of the overall mean for certified and indicative value, respectively. At combined uncertainties presented, the contribution of uncertainty of characterization of a particular property value is dominant.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/ANALYTIKA_Table_1_Certified_and_indicative_values_of_contents_of_element_fractions_extractable_by_f56fa06aa5.jpg" alt="ANALYTIKA: Table 1 - Certified and indicative values of contents of element fractions extractable by aqua regia in CRM AN-ZP01 and AN-ZP02 and their associated uncertainties." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_ANALYTIKA_Table_1_Certified_and_indicative_values_of_contents_of_element_fractions_extractable_by_f56fa06aa5.jpg 187w," sizes="100vw" width="998" height="835"><h5>Chemical composition of soil matrix:&nbsp;</h5>The bulk composition of CRM AN-ZP01 and AN-ZP02 is shown in Table 2. The values presented in this table are not certified, but they may be useful for considerations concerning possible interferences while determining analytes given in Table 1, and for selection of suitable decomposition procedures if destructive analytical methods are to be used.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/ANALYTIKA_Table_2_Matrix_composition_of_CRM_AN_ZP_01_and_AN_ZP_02_of_the_oxides_dry_cd1273cf9c.jpg" alt="ANALYTIKA: Table 2 Matrix composition of CRM AN-ZP01 and AN-ZP02 (% of the oxides dry weight at 105°C)" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_ANALYTIKA_Table_2_Matrix_composition_of_CRM_AN_ZP_01_and_AN_ZP_02_of_the_oxides_dry_cd1273cf9c.jpg 170w," sizes="100vw" width="883" height="811"><h5>Note:&nbsp;</h5>Detailed information about the production, homogeneity testing and characterization of these CRM are described in the Certification report, which is available on request.

Matrix CRM of agricultural soil METRANAL® CRM AN-ZP01 and AN-ZP02

<div><div><div>Our immune system is incredibly powerful: among other things, it can recognize and destroy cancer cells. But tumors can be just as effective at avoiding detection – they build “invisibility shields” to protect themselves from attack.</div></div><div>One breakthrough in cancer therapy has been immune checkpoint inhibitors (ICIs), drugs that reactivate immune T cells and help them fight tumors again. However, only about 20–50% of patients respond well to this treatment. Researchers are therefore seeking alternative therapeutic strategies. A small and well-known molecule called adenosine plays a key role in these efforts.When tumor cells are stressed or dying, they release ATP, which is normally a signal that something is wrong in the tissue. But in the tumor microenvironment, ATP gets rapidly broken down by two enzymes, CD39 and CD73. Released adenosine acts like a chemical “calm-down” signal, binds to immune cells (T cells, NK cells, and others), and tells them to slow down, reducing their ability to kill cancer cells. Targeting CD73 therefore represents a promising strategy for developing new cancer treatments.</div><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/UOCHB_Nove_latky_mohou_podporit_imunitni_system_v_boji_s_rakovinou_88c5e82cd5.jpeg" alt="IOCB Prague: Development of potent inhibitors to boost the immune system's ability to fight cancer" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_UOCHB_Nove_latky_mohou_podporit_imunitni_system_v_boji_s_rakovinou_88c5e82cd5.jpeg 245w," sizes="100vw" width="661" height="363">At IOCB Prague, interdisciplinary teams led by Jan Řezáč, Jan Konvalinka, and Michal Hocek used a newly developed high-throughput screening method to test over 5,000 compounds, identifying two ribonucleoside derivatives as promising CD73 inhibitors.The scientists then improved the compounds’ activity by carefully modifying the ribonucleoside scaffold with bulky (het)aryl groups. Further optimization improved the pharmacokinetic properties of these compounds, yielding inhibitors with low clearance, long half-life, high solubility, and strong selectivity over related enzymes such as CD39.In cellular experiments, the compounds reduced adenosine production in cancer cells, restored T cell activation, and showed no toxicity toward human fibroblasts. The most active compound showed a single-digit picomolar inhibition constant (Ki).These findings establish a strong foundation for further in vivo efficacy and combination studies, which will explore the therapeutic potential of this novel inhibitor class.<blockquote><h4>The Original article</h4><h4><a target="_blank" rel="noopener noreferrer" href="https://pubs.acs.org/doi/10.1021/acsptsci.5c00707">Potent Competitive Inhibitors of Ecto-5′-nucleotidase (CD73) based on 6-(Het)aryl-7-deazapurine Ribonucleoside 5′-O-Bisphosphonates</a></h4>Ugnė Šinkevičiu̅tė, Magdalena Šímová, Radek Staník, Lenka Poštová Slavětínská, Kristýna Blažková, Pavel Šácha, Martin Lepšík, Jan Řezáč, Jan Konvalinka, Tereza Ormsby, Michal Tichý, Michal HocekACS Pharmacol. Transl. Sci. 2026, 9, 1, 191–213<a target="_blank" rel="noopener noreferrer" href="https://pubs.acs.org/doi/10.1021/acsptsci.5c00707">https://pubs.acs.org/doi/10.1021/acsptsci.5c00707</a><h6>licensed under <a target="_blank" rel="noopener noreferrer" href="https://creativecommons.org/licenses/by/4.0/">CC-BY 4.0</a></h6></blockquote><h4>Abstract</h4>CD73 generates immunosuppressive adenosine in the tumor microenvironment and is a promising target for cancer immunotherapy. We have designed and systematically studied diverse 2-substituted 7-deazapurine ribonucleoside 5′-O-bisphosphonates bearing a variety of (het)aryl groups at position 6 and discovered their highly potent and selective CD73 inhibition activity. The most active compounds (with single-digit picomolar Ki) contained bicyclic (het)aryl groups at position 6 in combination with chlorine at position 2. Further optimization of pharmacokinetic properties identified inhibitors with low clearance, long half-life, high solubility, and excellent selectivity over CD39 and NTPDase3. They effectively suppressed adenosine formation in MDA-MB-231 cells, rescued CD8+ T cell activation, and were nontoxic to human fibroblasts. Overall, their profile compares favorably with AB680, a CD73 inhibitor currently in phase I/II clinical trials.</div>

Development of potent inhibitors to boost the immune system's ability to fight cancer

Article

Product

Application

Scientific article

Science and research

The Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences (IOCB Prague) is a leading scientific institution in the Czech Republic, recognized internationally. Its primary mission is basic research in the fields of chemical biology and medicinal chemistry, organic and material oriented chemistry, chemistry of natural compounds, biochemistry and molecular biology, physical chemistry, theoretical chemistry, and analytical chemistry. 

Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences

Everything from the world of analytical chemistry in one place. We connect people in solving their problems. At Labrulez you will find all the necessary information easily, quickly and clearly. Stop searching and start finding.

LabRulez

Analytika is a Czech company that offers and produces certified reference materials (CRM) and (ultra)pure chemicals for quality control and quality assurance in laboratories, including accredited laboratories.

Our portfolio also includes pipettes and tips, digestors, PFA labware and other equipment for analytical laboratory and trace analysis.

ANALYTIKA

Shimadzu Corporation

In this webinar, our panel of experts will discuss the market for alcohol-based hand sanitizers, the current regulatory environment, as well as analytical solutions including gas chromatography, Fourier-transform infrared spectroscopy, and UV-Vis spectroscopy to ensure the purity, potency, and safety of alcohols and hand sanitizers.
<blockquote>
Presenter: Nicole Zhang (Senior Product Specialist, Shimadzu Asia Pacific)
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<blockquote>
Nicole studies in UK in Microbiology and Immunology, prior joining Shimadzu, she worked in different companies in analytical instrument industry for more than 10 years, from Chemist to marketing and in charge of different technologies from LC, MS to Spectro products. She joined Shimadzu at the year of 2018 as spectroscopy product specialist and in charge of food quality and safety market.
</blockquote>
<blockquote>
Presenter: Jackie (Product Specialist (GC &amp; GCMS), Shimadzu Asia Pacific)
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After graduating from the National University of Singapore, Jackie has garnered over 6 years of research, training and facilitation experience. Jackie meets scientists from various industries to share technical knowledge and collect feedback, understanding their problems and helping them find well-suited solutions in GC-related analyses.
</blockquote>

Shimadzu: Stay Safe! Comprehensive Analysis of Alcohols and Hand Sanitizers

Stay Safe! Comprehensive Analysis of Alcohols and Hand Sanitizers

The market for alcohol-based hand sanitizers, the current regulatory environment, as well as analytical solutions including gas chromatography.

Comprehensive Analysis of Alcohols and Hand Sanitizers

This webcast will consist of two parts. Part 1 will start off with a basic introduction to luminescence terminology and electronic theory.
Particular attention will be given to photoluminescence, both fluorescence and phosphorescence. The webcast will then look at how molecular structure relates to spectral properties. Since all types of photoluminescence are sensitive to environmental conditions, we will consider how solvent properties, such as concentration, pH, and polarity, impact the photoluminescence spectrum. Part one will conclude with a summary on how fluorescence instruments function.
Part 2 will discuss several important materials characterization applications.
Under consideration first is correcting for the “instrumental artifact” inherent in all fluorescence instrumentation. Spectral correction is critical for accurate quantum yield measurements. The webcast will discuss both relative and absolute quantum yield measurement methods and their applications. To conclude the webcast the techniques of three-dimensional data acquisition and synchronous scanning will be discussed. Particular attention will be given to how these two different techniques relate to each other and how they can be properly employed and interpreted.
<blockquote>
Presenter: Jeffrey L. Taylor, Ph.D. (Molecular Spectroscopy Guru, Industry Expert With Over 35 Years of Experience)
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<blockquote>
Dr. Jeffrey L. Taylor received his Bachelor of Science degree from Georgia College and State University with dual majors in Physiology and Organic Chemistry. He obtained a Master of Science degree from the University of Georgia in Toxicology and later a Doctor of Philosophy degree from the same school in Biochemistry and Spectroscopy.
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He has spent his career of over 35 years with major spectroscopy instruments manufacturers, mainly working as Field Product Specialist and Senior Staff Scientist. Areas of expertise include technical support of sales, customer support/training, applications design and development, software specification/evaluation, and instrumental design and evaluation. He is the author of numerous application notes, conference presentations and webcasts, and holder of several patents.
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Dr. Taylor, although retired, maintains his desire to contribute to the field. He is currently a consultant for Shimadzu Scientific Instruments to assist with sales support, application support and development of web-based educational resources.
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<blockquote>
Presenter: Sudhir Dahal, Ph.D. (Product Manager - Molecular Spectroscopy, Shimadzu Scientific Instruments)
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<blockquote>
Sudhir Dahal is Product Manager of Molecular Spectroscopy group at Shimadzu Scientific Instruments, USA. He joined the company after obtaining his PhD from University of Maryland Baltimore County (UMBC), where he researched and collaborated on developing novel spectroscopy-based technique for brain tumor cell detection. At Shimadzu Scientific Instruments, he and his group are responsible for overall sales support of molecular spectroscopy products in North America, Central America and parts of South America. The products include UV-Vis-NIR, FTIR, Fluorescence spectrophotometers and accessories.
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His everyday responsibilities include, but are not limited to, teaching classes to sales/technical support engineers and customers, producing scientific literatures, researching new products and applications, representing Shimadzu at conferences and promoting the products through various marketing campaigns.
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Shimadzu: An Introduction to Light Emission Spectroscopy, with a focus on Fluorescence: Theory and Materials Characterization Applications

An Introduction to Light Emission Spectroscopy, with a focus on Fluorescence: Theory and Materials Characterization Applications

How molecular structure relates to spectral properties. Relative and absolute quantum yield measurement methods and their applications.

An Introduction to Light Emission Spectroscopy

Simple good practices for quality data including:
<ul>
<li>Sample prep and key accessories
</li>
<li>Attenuated Reflectance Accessory (ATR)
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<li>Overview
</li>
<li>Pros and Cons
</li>
<li>Tips for ATR analysis
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</ul>
</li>
<li>Environmental effects - CO2 and H2O
</li>
<li>Library search and precautions
</li>
<li>Micro analysis
<ul>
<li>Application examples</li>
</ul>
</li>
</ul>

FTIR Tips and Tricks Webinar

AA or ICP-OES/MS is often viewed as the golden standard to analyze elements during the pharmaceutical manufacturing process, from drug discovery to the QA/QC of final formulations.
While extremely accurate, these techniques have the downside of requiring the sample to be in liquid form when analyzing, resulting in a very arduous sample-preparation process and long analysis time.
In this seminar, we would introduce Energy-Dispersive X-Ray Fluoroscopy (EDX) as an alternative technique to perform elemental analysis that requires little sample preparation, is easy to use and can provide results quickly; and how it could be used in various areas of the pharmaceutical industry.
Learning Objectives:
<ul>
<li>Understanding how EDX can be used to perform elemental analysis
</li>
<li>Understanding how EDX can be used in the Pharma Industry
</li>
<li>Advantages of using EDX for elemental analysis
</li>
</ul>
<blockquote>
Presenter: Tan Teck Beng (Senior Product Specialist, Shimadzu (Asia Pacific) Pte. Ltd.)
</blockquote>
<blockquote>
Tan Teck Beng has been providing application support for XRF, XRD, EPMA, SPM and ESCA for the past 19 years in Shimadzu (Asia Pacific). He has conducted numerous Application Seminars and Workshops on Materials Characterization/Failure Analysis/Restriction of Hazardous Substances in many countries in the region, including Malaysia, Indonesia, Thailand, India, Philippines, Myanmar, Vietnam and Singapore.
</blockquote>
<blockquote>
He is currently providing Application and Technical Support for Shimadzu&#39;s Scientific Instruments for more than 200 companies in Asia Pacific Region.
</blockquote>
<blockquote>
Presenter: Mizuno Motohisa (Deputy General Manager, Scientific Sales, Shimadzu (Asia Pacific) Pte. Ltd.)
</blockquote>
<blockquote>
Mizuno-san has worked for Sales for the past 20 years in Shimadzu Japan. He has worked at Shimadzu’s Tokyo and Kyushu and Kansai branch offices and has extensive experience in catering to customers belonging to pharma, academia, food and chemical, among others. Before moving to Shimadzu (Asia Pacific), he served as a Sales Manager in the Kansai branch for the past 3 years, where he was in-charge of pharma customers as part of the Analytical &amp; Measuring Instruments Division.
</blockquote>

Shimadzu: EDX: A Fast & Simple Technique for Pharmaceutical Elemental Analysis

EDX: A Fast & Simple Technique for Pharmaceutical Elemental Analysis

Energy-Dispersive X-Ray Fluoroscopy (EDX) as an alternative technique to perform elemental analysis that requires little sample preparation.

EDX: A Fast & Simple Technique

Complying with the European Union (EU) or India&#39;s directive on Restriction of Hazardous Substances (RoHS) is an ongoing challenge for many companies.
Too often, their compliance activities are unnecessarily complicated by a lack of understanding about what the regulation requires, and how to stay compliant when new restricted substances are introduced. Here in this webinar, our expert team will try to explain about the latest regulation, its implications, along with easy testing solutions to stay compliant to avoid any enforcement action.
Learning Objectives:
<ul>
<li>Basic introduction &amp; history of RoHS
</li>
<li>Latest update on RoHS, RoHS2 regulation
</li>
<li>RoHS : Indian Scenario
</li>
<li>Solutions : Various testing methods
</li>
</ul>
<blockquote>
Presenter: Abhinandan Sharma (Asst. Manager - Sales, Shimadzu Analytical India Pvt Ltd)
</blockquote>
<blockquote>
Mr. Abhinandan Sharma has more than 15 years long experience of technical sales of analytical instruments and currently he is working for Shimadzu Analytical India Pvt Ltd since 2013 and looking after ED-XRF business for last 7 years.
</blockquote>
<blockquote>
Presenter: Pravin Tyagi (Manager - Sales, Shimadzu Analytical India Pvt Ltd)
</blockquote>
<blockquote>
Mr Pravin Tyagi is currently working as sales manager at Shimadzu Analytical India Pvt Ltd &amp; heading Indian business of scientific instrument division which includes EDX, XPS, EPMA, OES. He has been associated with Shimadzu since 2009 &amp; keep on organizing various application oriented seminars/workshops specifically designed to cater the requirement of various industries/institutes.
</blockquote>

Shimadzu: RoHS : Regulatory compliance and it's solutions

RoHS : Regulatory compliance and it's solutions

The latest regulation, its implications, along with easy testing solutions to stay compliant to avoid any enforcement action.

Over the past few decades, the widespread utility and applicability of X-ray photoelectron spectroscopy (XPS) in research and development has made it the most popular and widely used technique of surface analysis.
Our latest generation spectrometer, the AXIS Supra+, combines market leading spectroscopic and imaging capabilities with automation to ensure high sample throughput and ease of use. State-of-the-art performance including fast, high spatial resolution XPS imaging reveals the lateral distribution of surface chemistry and aids further characterisation with selected area analysis. We demonstrate the capabilities of the AXIS Supra+ and the technique of XPS in answering materials characterisation questions in application areas such as thin-films, biomaterials and Li-ion batteries.
Learning Objectives:
<ul>
<li>Understand the basic principles of XPS Instrumentation
</li>
<li>Achieve a total peace of mind for user through the highest level of automation
</li>
<li>Understand importance of high sensitivity &amp; high energy resolution XPS
</li>
<li>Explore new opportunities by high spatial resolution parallel imaging
</li>
</ul>
<blockquote>
Presenter: Simon Hutton (Ph.D.) (Sales Manager, Kratos Analytical Ltd)
</blockquote>
<blockquote>
Dr. Hutton is currently Sales Manager for surface analysis products at Kratos Analytical. He started as an applications specialist and still has a &#39;hands-on&#39; approach to instrument sales, acquiring applications data when time allows. Simon has many years experience of XPS and surface analysis.
</blockquote>
<blockquote>
 Presenter: Adam Roberts (Ph.D.) (Marketing Manager, Kratos Analytical Lt)
</blockquote>
<blockquote>
Dr. Roberts joined Kratos Analytical as an Applications Specialist in the Surface Analysis business in 1998. With over 20 years of experience in applications of surface analysis for materials characterisation Adam has great depth of knowledge of the subject. This scientific experience has been developed in parallel with commercial sales and marketing of the scientific instruments supplied by Kratos Analytical.
</blockquote>

Shimadzu: X-Ray Photoelectron Spectroscopy Technology

X-Ray Photoelectron Spectroscopy Technology

Understand the basic principles of XPS Instrumentation.

Recently, there is an increased demand for surface observation &amp; analysis of elemental distribution on sample surfaces, particularly for metals where it can be used for failure analyses.
Being the most effective non-destructive technique for qualitative and quantitative elemental analysis, Shimadzu would like to introduce the Electron Probe Micro-Analyzer (EPMA) as a precise &amp; accurate technique for surface characterization.
Learning Objectives:
<ul>
<li>Understand the principles behind EPMA
</li>
<li>Understand the difference between EPMA and SEM-EDS
</li>
<li>Explore how you can conduct micro-analysis using EPMA
</li>
</ul>
<blockquote>
Presenter: Eka Widianto Thamrin (Sales Executive, Shimadzu (Asia Pacific) Pte. Ltd.)
</blockquote>
<blockquote>
Eka Widianto Thamrin has been selling Shimadzu&#39;s Scientific Instruments such as OES, XRF, XRD, EPMA and SPM in Shimadzu (Asia Pacific) for the past 3 years. During this time, he has sold several EPMA units to universities, governments and private companies in various countries in the region, such as Thailand and India - including the first FE-EPMA unit in ASEAN.
</blockquote>
<blockquote>
Presenter: Tan Teck Beng (Senior Product Specialist, Shimadzu (Asia Pacific) Pte Ltd)
</blockquote>
<blockquote>
Tan Teck Beng is the Senior Product Specialist for Scientific Instrument in Shimadzu Asia Pacific. He has been providing application support for OES, XRF, XRD, EPMA, SPM and ESCA for the past 19 years. He has conducted numerous Application Seminars and Workshops on Materials Characterization/Failure Analysis/Restriction of Hazardous Substances in countries supported by Shimadzu Asia Pacific. The countries where he has conducted include Malaysia, Indonesia, Thailand, India, Philippines, Myanmar, Vietnam and Singapore. He is currently providing Application and Technical Support for Shimadzu Scientific Instruments for more than 200 companies in Asia Pacific Region utilizing shimadzu scientific instruments. He has an MSc degree in Materials Science from the National University of Singapore.
</blockquote>

Shimadzu: EPMA: A Revolutionary Approach to Micro-Analysis

EPMA: A Revolutionary Approach to Micro-Analysis

The Electron Probe Micro-Analyzer (EPMA) as a precise & accurate technique for surface characterization.

24 targeted elemental impurities in three drug products were determined following new USP chapters &lt;232&gt;/&lt;233&gt; using Shimadzu ICPMS-2030.
The method was evaluated and validated according to the procedures defined by USP &lt;233&gt; and combined with microwave digestion for sample preparation. Good calibration linearity, repeatability, stability and specificity were achieved for all 24 impurities. Low LODs and LOQs were obtained as compared to the target limits from USP &lt;232&gt;. The ICP-MS method applying universal He collision mode provides a high throughput method for routine elemental impurity analysis in pharmaceutical products. 
Learning Objectives:
<ul>
<li>Background and introduction to the new USP chapters &lt;232&gt;/&lt;233&gt; 
</li>
<li>Understand the ICP-MS method for elemental impurity analysis in drugs
</li>
<li>Explore the method evaluation and validation conducted
</li>
</ul>
<blockquote>
Presenter: Raymond Li (Ph.D) (Senior Application Chemist, Shimadzu (Asia Pacific))
</blockquote>
<blockquote>
Dr. Raymond joined Centre of Application Solutions, SAP since 2017. He obtained his B.S. from Nankai University in Material Chemistry in 2003 and Ph.D. from University of Singapore in 2008. He has been a research fellow at Agency for Science, Technology and Research (A*STAR), Singapore. Before joining Shimadzu, he has 7 years’ experience in the R&amp;D department at PerkinElmer. His expertise lies in elemental analysis in various applications and specializes in ICP and ICPMS.
</blockquote>

Shimadzu: Validation of Quantitative Method for Determination of Elemental Impurities in Pharmaceutical Products Following USP 232/233 on ICPMS-2030

Validation of Quantitative Method for Determination of Elemental Impurities in Pharmaceutical Products Following USP 232/233 on ICPMS-2030

Understand the ICP-MS method for elemental impurity analysis in drugs.

Validation of Quantitative Method for Determination

This webcast will consist of two parts. Part 1 will start off with a basic introduction to UV/Vis/NIR integrating spheres.
We will then consider samples, such as plastic films and colored Spectralon®, that illustrate how sphere diameter can impact spectral accuracy in both reflectance and scatter transmission measurements. This section will conclude with a look at how sample surface texture and sample placement against the sphere’s port, can result in unusual artifacts in the spectra.
Part 2 will discuss two novel integrating sphere applications within the rapidly growing technology field of nanomaterials.
Carbon nanotubes constitute a large arena of products where UV/Vis/NIR spectroscopy, employing an integrating sphere, is functional in both research and quality control. The webcast will conclude with a detailed look at the UV/Vis/NIR spectroscopy of butterfly wings. The colors on most butterfly wings do not arise from either dyes or pigments, but from nanostructures that physically diffract, rather than absorb light. As such, they represent an interesting platform to investigate the potential for spectroscopic materials characterization of nanostructures attached to surfaces.
<blockquote>
Presenter: Jeffrey L. Taylor, Ph.D. (Molecular Spectroscopy Guru, Industry Expert With Over 35 Years of Experience)
</blockquote>
<blockquote>
Dr. Jeffrey L. Taylor received his Bachelor of Science degree from Georgia College and State University with dual majors in Physiology and Organic Chemistry. He obtained a Master of Science degree from the University of Georgia in Toxicology and later a Doctor of Philosophy degree from the same school in Biochemistry and Spectroscopy.
</blockquote>
<blockquote>
He has spent his career of over 35 years with major spectroscopy instruments manufacturers, mainly working as Field Product Specialist and Senior Staff Scientist. Areas of expertise include technical support of sales, customer support/training, applications design and development, software specification/evaluation, and instrumental design and evaluation. He is the author of numerous application notes, conference presentations and webcasts, and holder of several patents.
</blockquote>
<blockquote>
Dr. Taylor, although retired, maintains his desire to contribute to the field. He is currently a consultant for Shimadzu Scientific Instruments to assist with sales support, application support and development of web-based educational resources.
</blockquote>
<blockquote>
Presenter: Sudhir Dahal, Ph.D. (Product Manager - Molecular Spectroscopy, Shimadzu Scientific Instruments)
</blockquote>
<blockquote>
Sudhir Dahal is Product Manager of Molecular Spectroscopy group at Shimadzu Scientific Instruments, USA. He joined the company after obtaining his PhD from University of Maryland Baltimore County (UMBC), where he researched and collaborated on developing novel spectroscopy-based technique for brain tumor cell detection. At Shimadzu Scientific Instruments, he and his group are responsible for overall sales support of molecular spectroscopy products in North America, Central America and parts of South America. The products include UV-Vis-NIR, FTIR, Fluorescence spectrophotometers and accessories.
</blockquote>
<blockquote>
His everyday responsibilities include, but are not limited to, teaching classes to sales/technical support engineers and customers, producing scientific literatures, researching new products and applications, representing Shimadzu at conferences and promoting the products through various marketing campaigns.
</blockquote>

Shimadzu: Plastic Films, Fabrics, Nano Particles, and Butterfly Wings: Novel, “Outside the Box”, Uses For UV/Vis/NIR Integrating Spheres

Plastic Films, Fabrics, Nano Particles, and Butterfly Wings: Novel, “Outside the Box”, Uses For UV/Vis/NIR Integrating Spheres

Basic introduction to UV/Vis/NIR integrating spheres. Two novel integrating sphere applications within the rapidly growing technology field of nanomaterials.

Plastic Films, Fabrics, Nano Particles, and Butterfly Wings

Most people think solutions in a cuvette when referring to spectrophotometers; however, in the world of materials characterization, rarely are solutions the primary sample.
Here the samples can be anything from solid, creams, gels, particle suspensions, films, and in some cases actual human beings (sunscreen characterization). These samples all have one thing in common, they are impossible to dilute. The materials characterization high performance spectrophotometer must have the ability to measure high absorbance values (8 to 10 absorbance units). Instrumental parameters that are crucial to measuring materials characterization samples are stray light, noise, resolution, and scan speed. In this presentation we will address how these inter-related parameters influence measurement success.
Most measurements for the above-mentioned samples are not of the simple transmission type. Reflection, both specular and diffuse, and scatter transmission measurements abound in the world of materials characterization. It is vital that the proper accessory be employed to match the measurement desired. This presentation will address the function of integrating spheres and how they can be used to measure both diffuse reflection and transmission. Also discussed will be the difference between a relative and absolute reflection measurement. Finally, an overview will be given of important accessories related to the materials characterization marketplace. Register now!
<blockquote>
Presenter: Jeffrey L. Taylor, Ph.D. (Molecular Spectroscopy Guru, Industry Expert With Over 35 Years of Experience)
</blockquote>
<blockquote>
Dr. Jeffrey L. Taylor received his Bachelor of Science degree from Georgia College and State University with dual majors in Physiology and Organic Chemistry. He obtained a Master of Science degree from the University of Georgia in Toxicology and later a Doctor of Philosophy degree from the same school in Biochemistry and Spectroscopy.
</blockquote>
<blockquote>
He has spent his career of over 35 years with major spectroscopy instruments manufacturers, mainly working as Field Product Specialist and Senior Staff Scientist. Areas of expertise include technical support of sales, customer support/training, applications design and development, software specification/evaluation, and instrumental design and evaluation. He is the author of numerous application notes, conference presentations and webcasts, and holder of several patents.
</blockquote>
<blockquote>
Dr. Taylor, although retired, maintains his desire to contribute to the field. He is currently a consultant for Shimadzu Scientific Instruments to assist with sales support, application support and development of web-based educational resources.
</blockquote>
<blockquote>
Presenter: Sudhir Dahal, Ph.D. (Product Manager - Molecular Spectroscopy, Shimadzu Scientific Instruments)
</blockquote>
<blockquote>
Sudhir Dahal is Product Manager of Molecular Spectroscopy group at Shimadzu Scientific Instruments, USA. He joined the company after obtaining his PhD from University of Maryland Baltimore County (UMBC), where he researched and collaborated on developing novel spectroscopy-based technique for brain tumor cell detection. At Shimadzu Scientific Instruments, he and his group are responsible for overall sales support of molecular spectroscopy products in North America, Central America and parts of South America. The products include UV-Vis-NIR, FTIR, Fluorescence spectrophotometers and accessories.
</blockquote>
<blockquote>
His everyday responsibilities include, but are not limited to, teaching classes to sales/technical support engineers and customers, producing scientific literatures, researching new products and applications, representing Shimadzu at conferences and promoting the products through various marketing campaigns.
</blockquote>

Shimadzu: UV/Vis/NIR Spectroscopy in the Arena of Materials Characterization Research and Quality Control: How Instrumental Performance and Accessories Define Success

UV/Vis/NIR Spectroscopy in the Arena of Materials Characterization Research and Quality Control: How Instrumental Performance and Accessories Define Success

The function of integrating spheres and how they can be used to measure both diffuse reflection and transmission.