<p><strong>In the next 14 days, the following webinars await you in the field of atomic and molecular spectroscopy and spectrometry</strong></p>
<blockquote>
<h4><a href="https://icpms.labrulez.com/webinars"><strong>👉 DETAILS AND REGISTRATION IN THE WEBINARS SECTION</strong></a></h4>
</blockquote>
<h5><strong>1. Thermo Fisher Scientific: NGS success: Next-generation sequencing sample preparation with the NanoDrop One spectrophotometer</strong></h5>
<ul>
<li>Mo, 15.1.2024, 16:00 CET</li>
<li><a href="https://icpms.labrulez.com/webinar/3393">Registration</a></li>
</ul>
<p>This webinar will provide an overview of the NanoDrop One/OneC spectrophotometer as an easier and cheaper alternative to qPCR for ensuring high-quality sequencing data.</p>
<h5><strong>2. Agilent Technologies: The Speciation Connection</strong></h5>
<ul>
<li>We, 17.1.2024, 11:00 CET</li>
<li><a href="https://icpms.labrulez.com/webinar/2879">Registration</a></li>
</ul>
<p>Overcoming obstacles of speciation testing by providing guidance and a path of best practice.</p>
<h5><strong>3. Separation Science/Agilent Technologies: Improving Efficiency in the Lab with ICP-OES and ICP-MS Analyses</strong></h5>
<ul>
<li>Th, 18.1.2024, 11:00 CET</li>
<li><a href="https://icpms.labrulez.com/webinar/3363">Registration</a></li>
</ul>
<p>Discover tips that can help you improve efficiency for your ICP-OES and ICP-MS analyses without shortcuts that may otherwise sacrifice quality.</p>
<h5><strong>4. Agilent Technologies: Winter Plasma Conference 2024 Highlights on Agilent ICP-OES and ICP-MS Applications: Part 1</strong></h5>
<ul>
<li>Fr, 19.1.2024, 18:00 CET</li>
<li><a href="https://icpms.labrulez.com/webinar/3141">Registration</a></li>
</ul>
<p>New and exciting instrumentations and applications in the atomic spectroscopy area.</p>


Webinars LabRulezICPMS Week 2-3/2024

<p><strong>LabRulez is the name of a group of web portals that uniquely link and present information in the field of analytical chemistry, separation techniques, spectroscopy or chemistry, research and technologies.</strong></p>
<p>The portal currently consists of three main parts and its scope is expanding.</p>
<ul>
<li><p><a href="https://lcms.labrulez.com/"><strong>LabRulezLCMS (ENG)</strong></a> focused on the liquid phase.</p>
</li>
<li><p>The <a href="https://lcms.cz/"><strong>LabRulezLCMS (CZ)</strong></a></p>
</li>
<li><p><a href="https://gcms.labrulez.com/"><strong>LabRulezGCMS (ENG)</strong></a> focused on the gas and solid phases.</p>
</li>
<li><p><a href="https://gcms.cz/"><strong>LabRulezGCMS (CZ)</strong></a></p>
</li>
<li><p>NEW: <a href="https://icpms.labrulez.com/"><strong>LabRulezICPMS (ENG)</strong></a> focused on atomic and molecular spectroscopy.</p>
</li>
<li><p>NEW: <a href="https://icpms.cz/"><strong>LabRulezICPMS (CZ)</strong></a></p>
</li>
</ul>
<p>For the LabRulez portals, <strong>year 2023 was a very successful year</strong>, especially in terms of traffic growth, but also in terms of content and partners. In terms of statistics, we achieved almost 100% growth compared to 2022 in all areas:</p>
<ul>
<li>more than <strong>20,740,000 impressions on Google alone</strong>.</li>
<li>more than <strong>918,000 opened applications</strong> in our unique library</li>
<li>more than <strong>654,000 page views</strong></li>
<li>more than (3)<strong>146,000 unique visitors</strong></li>
</ul>
<p>As a media partner, we have attended and shared information from <a href="https://lcms.cz/articles?tags=9"><strong>14 Czech/Slovak conferences or seminars</strong></a> and this January we are also proud to be a partner of the international conference on <a href="https://gcms.labrulez.com/companies/218"><strong>multi-dimensional chromatography (GCxGC, 2D-LC) MDCW</strong></a> which will take place in Los Angeles (USA) this week.</p>
<blockquote>
<p>Become part of our portals and community and raise awareness of your work, products or services. Build your brand and attract new customers, partners and projects in a targeted community of analytical chemists or in internet search engines. Anyone can take advantage of the LabRulez portals:</p>
</blockquote>
<blockquote>
<ul>
<li><strong>Commercial business</strong> company (products and services)</li>
<li><strong>Commercial laboratory</strong> (services and expertise)</li>
<li><strong>State institutions and laboratories</strong> (public information and HR)</li>
<li><strong>Universities and research institutions</strong> (project outputs, publications, popularization)</li>
<li><strong>Groups or individuals</strong> (commercial or academic)</li>
</ul>
</blockquote>
<blockquote>
<p><em>Contact us at info@labrulez.com or by phone and we will be happy to discuss all the details with you</em>.</p>
</blockquote>
<p>On the portals you can follow <strong>webinars</strong>, <strong>scientific events and exhibitions</strong>, <strong>professional and popularization news</strong> or <strong>job offers</strong>. Search and filter through <strong>hundreds of products</strong> in one place. Plus, view or download documents from <strong>an extensive and unique library</strong> that includes apps, scientific and technical articles, posters, manuals, or presentations. LabRulez is thus a comprehensive source of knowledge and information for analytical chemists and anyone interested in the field.</p>
<p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Lab_Rulez_Banner_2023_24_ENG_f192298172/LabRulez-Banner-2023-24-ENG.jpg" alt="LabRulez: LabRulez results in 2023"/></p>
<h3>Finally, <strong>we asked a general question to the AI BING</strong> , an artificial intelligence that has access to the online environment, and what did we learn?</h3>
<h5><strong>LabRulez query for AI BING</strong></h5>
<p>Why would you recommend that analytical chemists regularly visit the LabRulez portals?</p>
<h5><strong>Answer from AI BING</strong></h5>
<p>I would recommend that analytical chemists regularly visit LabRulez portals because:</p>
<ul>
<li><p>LabRulez portals provide <strong>updated and high quality</strong> information on analytical chemistry, chromatography, spectroscopy and other related techniques.</p>
</li>
<li><p>On LabRulez portals you can <strong>expand your knowledge and skills¨</strong> through webinars, events, articles and products from various companies and experts.</p>
</li>
<li><p>On LabRulez portals, you have <strong>unique access</strong> to an extensive and growing database that includes applications, scientific and technical articles, posters, manuals and presentations.</p>
</li>
<li><p>On the LabRulez portals you can <strong>find or offer jobs</strong>, <strong>sell or buy analytical instrumentation</strong>, <strong>services</strong> or opportunities to access the growing requirements of your laboratories.</p>
</li>
</ul>
<h5><strong>LabRulez Summary</strong></h5>
<p><strong>What more to say? Perhaps it&#39;s that we&#39;re really preparing and improving a lot for you in 2024... Maybe at the end of this year you&#39;ll be able to talk to AI about your requirements and problems in our globally unique academic section</strong>.</p>
<p><strong>Keep your fingers crossed, support us, become part of us and build with us a purely Czech project with global ambitions.</strong></p>


LabRulez portals in 2023 (How was it?)

<p><strong>In the week from 15th of January, the following webinars await you in the field of atomic and molecular spectroscopy and spectrometry</strong></p>
<blockquote>
<h4><a href="https://icpms.labrulez.com/webinars"><strong>👉 DETAILS AND REGISTRATION IN THE WEBINARS SECTION</strong></a></h4>
</blockquote>
<h5><strong>1. Thermo Fisher Scientific: NGS success: Next-generation sequencing sample preparation with the NanoDrop One spectrophotometer</strong></h5>
<ul>
<li>Mo, 15.1.2024, 16:00 CET</li>
<li><a href="https://icpms.labrulez.com/webinar/3393">Registration</a></li>
</ul>
<p>This webinar will provide an overview of the NanoDrop One/OneC spectrophotometer as an easier and cheaper alternative to qPCR for ensuring high-quality sequencing data.</p>
<h5><strong>2. TESCAN: Disclosing the Future of Lithium-Ion Batteries with Advanced Characterization Techniques</strong></h5>
<ul>
<li>Tu, 16.1.2024, 17:00 CET</li>
<li><a href="https://icpms.labrulez.com/webinar/3416">Registration</a></li>
</ul>
<p>This webinar titled “Comprehensive Characterization of Lithium-Ion Battery Materials using TESCAN FIB-SEM with integrated ToF-SIMS” is set to be insightful event in the battery research community. </p>
<h5><strong>3. Agilent Technologies: The Speciation Connection</strong></h5>
<ul>
<li>We, 17.1.2024, 11:00 CET</li>
<li><a href="https://icpms.labrulez.com/webinar/2879">Registration</a></li>
</ul>
<p>Overcoming obstacles of speciation testing by providing guidance and a path of best practice.</p>
<h5><strong>4. Separation Science/Agilent Technologies: Improving Efficiency in the Lab with ICP-OES and ICP-MS Analyses</strong></h5>
<ul>
<li>Th, 18.1.2024, 11:00 CET</li>
<li><a href="https://icpms.labrulez.com/webinar/3363">Registration</a></li>
</ul>
<p>Discover tips that can help you improve efficiency for your ICP-OES and ICP-MS analyses without shortcuts that may otherwise sacrifice quality.</p>
<h5><strong>5. Agilent Technologies: Winter Plasma Conference 2024 Highlights on Agilent ICP-OES and ICP-MS Applications: Part 1</strong></h5>
<ul>
<li>Fr, 19.1.2024, 18:00 CET</li>
<li><a href="https://icpms.labrulez.com/webinar/3141">Registration</a></li>
</ul>
<p>New and exciting instrumentations and applications in the atomic spectroscopy area.</p>


Webinars LabRulezICPMS Week 3/2024

<p><strong>In the week from 22th of January, the following webinars await you in the field of atomic and molecular spectroscopy and spectrometry</strong></p>
<blockquote>
<h4><a href="https://icpms.labrulez.com/webinars"><strong>👉 DETAILS AND REGISTRATION IN THE WEBINARS SECTION</strong></a></h4>
</blockquote>
<h5><strong>1. Agilent Technologies: Error-Free Sample Preparation Workflows</strong></h5>
<ul>
<li>Mo, 22.1.2024, 11:00 CET</li>
<li><a href="https://icpms.labrulez.com/webinar/3413">Registration</a></li>
</ul>
<p>Agilent and METTLER TOLEDO have jointly developed an integrated workflow solution that addresses the most pressing root causes for laboratory failure investigations.</p>
<h5><strong>2. PerkinElmer: Breaking Down Black Mass: Strategies and Insights for Effective ICP-OES Analysis</strong></h5>
<ul>
<li>We, 24.1.2024, 19:00 CET</li>
<li><a href="https://icpms.labrulez.com/webinar/3384">Registration</a></li>
</ul>
<p>Join us for an insightful webinar on the latest PerkinElmer application note, &quot;Comparing Sample Preparation Strategies for the Determination of Major Components in Black Mass with the Avio 550 Max ICP-OES.&quot;</p>
<h5><strong>3. Shimadzu Corporation: For the Love of Food! Solutions for Contaminants From PFAS to Heavy Metals</strong></h5>
<ul>
<li>Th, 25.1.2024, 07:30 CET</li>
<li><a href="https://icpms.labrulez.com/webinar/3357">Registration</a></li>
</ul>
<p>Gear up for an exciting session leading to the heart of food safety analysis, focusing on 3 crucial aspects: organic contaminants identification, elemental analysis, and the pressing issue of PFAS.</p>
<h5><strong>4. Wiley: Streamline Your NMR Workflow with KnowItAll – Processing, Analysis, Predictions, &amp; Beyond</strong></h5>
<ul>
<li>Th, 25.1.2024, 16:00 CET</li>
<li><a href="https://icpms.labrulez.com/webinar/3359">Registration</a></li>
</ul>
<p>Learn how Wiley’s KnowItAll NMR package can be used to solve your spectroscopy problems.</p>
<h5><strong>5. Agilent Technologies: Learn Why Atomic Absorption, MicroWave, and ICP Plasma Spectroscopy are the Perfect Tools for Both a Teaching and Research Environment</strong></h5>
<ul>
<li>Th, 25.1.2024, 19:00 (CEST)</li>
<li><a href="https://icpms.labrulez.com/webinar/3158">Registration</a></li>
</ul>
<p>We will discuss each of the above techniques and outline the advantages and challenges of each.</p>
<h5><strong>6. Agilent Technologies: Expanding Your UV-Vis Sampling Capabilities with the Cary 3500 Flexible Module</strong></h5>
<ul>
<li>Fr, 26.1.2024, 19:00 CET</li>
<li><a href="https://icpms.labrulez.com/webinar/3352">Registration</a></li>
</ul>
<p>In this talk/demo, we will explore how the Flexible Module of the Cary 3500 expands one’s sampling capabilities.</p>


Webinars LabRulezICPMS Week 4/2024

<p><strong>In the next 14 days, the following webinars await you in the field of atomic and molecular spectroscopy and spectrometry</strong></p>
<blockquote>
<h4><a href="https://icpms.labrulez.com/webinars"><strong>👉 DETAILS AND REGISTRATION IN THE WEBINARS SECTION</strong></a></h4>
</blockquote>
<h5><strong>1. Agilent Technologies: Winter Plasma Conference 2024 Highlights on Agilent ICP-OES and ICP-MS Applications: Part 2</strong></h5>
<ul>
<li>Fr, 2.2.2024, 18:00 CET</li>
<li><a href="https://icpms.labrulez.com/webinar/3142">Registration</a></li>
</ul>
<p>New and exciting instrumentations and applications in the atomic spectroscopy area.</p>
<h5><strong>2. Agilent Technologies: Part 2: The Mining Lifecycle and Elemental Analysis Workshop Series</strong></h5>
<ul>
<li>Tu, 6.2.2024, 21:30 CET</li>
<li><a href="https://icpms.labrulez.com/webinar/3212">Registration</a></li>
</ul>
<p>Agilent Technologies invites you to a three-part series to discuss all aspects of elemental analysis involved in the complete mine lifecycle.</p>
<h5><strong>3. C&amp;EN/Repligen: Variable Pathlength Spectroscopy for Dilution-Free Concentration Measurement in GMP Environments</strong></h5>
<ul>
<li>We, 7.2.2024, 17:00 CET</li>
<li><a href="https://icpms.labrulez.com/webinar/3426">Registration</a></li>
</ul>
<p>In this webinar, we will review VPT and how it can be used in various applications from protein to nucleic acid therapeutics.</p>
<h5><strong>4. Agilent Technologies: Plant and Soil Analysis for the Determination of their Inorganic Content</strong></h5>
<ul>
<li>Th, 8.2.2024, 11:00 CET</li>
<li><a href="https://icpms.labrulez.com/webinar/3422">Registration</a></li>
</ul>
<p>In this webinar we will present the different technics available from Agilent to assess agricultural samples such as soils and plant materials.</p>
<h5><strong>5. Agilent Technologies: From Single Cell and Nanoparticle analysis to Laser Ablation and Beyond: Advanced ICP-MS Research Applications</strong></h5>
<ul>
<li>Th, 8.2.2024, 19:00 CET</li>
<li><a href="https://icpms.labrulez.com/webinar/3159">Registration</a></li>
</ul>
<p>NanoParticle, Single Cell, Speciation, Laser Ablation, and other hyphenated ICP-MS applications that can advance your research.</p>
<h5><strong>6. Agilent Technologies: An Easy Way to Measure Liquids in Transmission Using FTIR</strong></h5>
<ul>
<li>Fr, 9.2.2024, 19:00 CET</li>
<li><a href="https://icpms.labrulez.com/webinar/3353">Registration</a></li>
</ul>
<p>This session will demonstrate a simple way to collect IR spectra of liquids in transmission without the hassle of extensive cleaning processes of traditional liquid cells.</p>


Webinars LabRulezICPMS Week 5-6/2024

<p><strong>In the week from 5th of February, the following webinars await you in the field of atomic and molecular spectroscopy and spectrometry</strong></p>
<blockquote>
<h4><a href="https://icpms.labrulez.com/webinars"><strong>👉 DETAILS AND REGISTRATION IN THE WEBINARS SECTION</strong></a></h4>
</blockquote>
<h5><strong>1. Agilent Technologies: Part 2: The Mining Lifecycle and Elemental Analysis Workshop Series</strong></h5>
<ul>
<li>Tu, 6.2.2024, 21:30 CET</li>
<li><a href="https://icpms.labrulez.com/webinar/3212">Registration</a></li>
</ul>
<p>Agilent Technologies invites you to a three-part series to discuss all aspects of elemental analysis involved in the complete mine lifecycle.</p>
<h5><strong>2. C&amp;EN/Repligen: Variable Pathlength Spectroscopy for Dilution-Free Concentration Measurement in GMP Environments</strong></h5>
<ul>
<li>We, 7.2.2024, 17:00 CET</li>
<li><a href="https://icpms.labrulez.com/webinar/3426">Registration</a></li>
</ul>
<p>In this webinar, we will review VPT and how it can be used in various applications from protein to nucleic acid therapeutics.</p>
<h5><strong>3. Agilent Technologies: Plant and Soil Analysis for the Determination of their Inorganic Content</strong></h5>
<ul>
<li>Th, 8.2.2024, 11:00 CET</li>
<li><a href="https://icpms.labrulez.com/webinar/3422">Registration</a></li>
</ul>
<p>In this webinar we will present the different technics available from Agilent to assess agricultural samples such as soils and plant materials.</p>
<h5><strong>4. Agilent Technologies: From Single Cell and Nanoparticle analysis to Laser Ablation and Beyond: Advanced ICP-MS Research Applications</strong></h5>
<ul>
<li>Th, 8.2.2024, 19:00 CET</li>
<li><a href="https://icpms.labrulez.com/webinar/3159">Registration</a></li>
</ul>
<p>NanoParticle, Single Cell, Speciation, Laser Ablation, and other hyphenated ICP-MS applications that can advance your research.</p>
<h5><strong>5. Agilent Technologies: An Easy Way to Measure Liquids in Transmission Using FTIR</strong></h5>
<ul>
<li>Fr, 9.2.2024, 19:00 CET</li>
<li><a href="https://icpms.labrulez.com/webinar/3353">Registration</a></li>
</ul>
<p>This session will demonstrate a simple way to collect IR spectra of liquids in transmission without the hassle of extensive cleaning processes of traditional liquid cells.</p>


Webinars LabRulezICPMS Week 6/2024

<p><strong>In the next 14 days, the following webinars await you in the field of atomic and molecular spectroscopy and spectrometry</strong></p>
<blockquote>
<h4><a href="https://icpms.labrulez.com/webinars"><strong>👉 DETAILS AND REGISTRATION IN THE WEBINARS SECTION</strong></a></h4>
</blockquote>
<blockquote>
<p><strong>👉 Search and filter in the largest global database</strong>  with over <strong>3 500 GC, LC, MS and spectroscopy webinars</strong>.</p>
</blockquote>
<h5><strong>1. Agilent Technologies: Analyzing Trace and Major Elements in Food Samples</strong></h5>
<ul>
<li>Tu, 13.2.2024, 11:00 CET</li>
<li><a href="https://icpms.labrulez.com/webinar/3423">Registration</a></li>
</ul>
<p>In this talk different approaches of plasma techniques (MP-AES, ICP-OES and -MS) to determine elemental content in food samples will be discussed.</p>
<h5><strong>2. Agilent Technologies: Part 3: The Mining Lifecycle and Elemental Analysis Workshop Series</strong></h5>
<ul>
<li>Tu, 13.2.2024, 21:30 CET</li>
<li><a href="https://icpms.labrulez.com/webinar/3213">Registration</a></li>
</ul>
<p>Agilent Technologies invites you to a three-part series to discuss all aspects of elemental analysis involved in the complete mine lifecycle.</p>
<h5><strong>3. Agilent Technologies: Find Your Perfect Match at Agilent’s Valentine Cyber Sale</strong></h5>
<ul>
<li>Th, 15.2.2024, 10:00 CET</li>
<li><a href="https://icpms.labrulez.com/webinar/3516">Registration</a></li>
</ul>
<p>Find chemistry you can trust, in our extensive refurbished analytical instrument portfolio, including chromatography, spectroscopy, mass spectrometry and automation.</p>
<h5><strong>4. Wiley: Introduction to KnowItAll for IR &amp; Raman (Vibrational Spectroscopy)</strong></h5>
<ul>
<li>Th, 22.2.2024, 16:00 CET</li>
<li><a href="https://icpms.labrulez.com/webinar/3570">Registration</a></li>
</ul>
<p>We will demonstrate how KnowItAll can help solve unknown IR and Raman spectra through a series of examples.</p>
<h5><strong>5. Agilent Technologies: Tips and Tricks Workshop on ICP-OES: Smarter Method Development</strong></h5>
<ul>
<li>Th, 22.2.2024, 19:00 (CEST)</li>
<li><a href="https://icpms.labrulez.com/webinar/3160">Registration</a></li>
</ul>
<p>Techniques on how to achieve the best sensitivity and detection limits through tuning techniques and strategies.</p>
<h5><strong>6. Agilent Technologies: See Through the Barrier: The Power of Agilent&#39;s Solutions for Raw Material Verification</strong></h5>
<ul>
<li>Fr, 23.2.2024, 19:00 CET</li>
<li><a href="https://icpms.labrulez.com/webinar/3354">Registration</a></li>
</ul>
<p>This talk will delve into the prowess of these Agilent Spatially Offset Raman spectrometers, emphasizing their capability to ensure material authenticity even through obstructions.</p>


Webinars LabRulezICPMS Week 7-8/2024

<p><strong>In the next 14 days, the following webinars await you in the field of atomic and molecular spectroscopy and spectrometry</strong></p>
<blockquote>
<h4><a href="https://icpms.labrulez.com/webinars"><strong>👉 DETAILS AND REGISTRATION IN THE WEBINARS SECTION</strong></a></h4>
</blockquote>
<blockquote>
<p><strong>👉 Search and filter in the largest global database</strong>  with over <strong>3 500 GC, LC, MS and spectroscopy webinars</strong>.</p>
</blockquote>
<h5><strong>1. Bruker Daltonics: Advancements in Operando NMR Analysis of Lithium-Ion Batteries</strong></h5>
<ul>
<li>We, 21.2.2024, 17:00 CET</li>
<li><a href="https://icpms.labrulez.com/webinar/3575">Registration</a></li>
</ul>
<p>Join Dragonfly Energy, Darmstadt Technical University, ePROBE and BRUKER BioSpin as they discuss an experimental procedure for application of in-situ Solid-State NMR for battery research and manufacturing.</p>
<h5><strong>2. Wiley: Introduction to KnowItAll for IR &amp; Raman (Vibrational Spectroscopy)</strong></h5>
<ul>
<li>Th, 22.2.2024, 16:00 CET</li>
<li><a href="https://icpms.labrulez.com/webinar/3570">Registration</a></li>
</ul>
<p>We will demonstrate how KnowItAll can help solve unknown IR and Raman spectra through a series of examples.</p>
<h5><strong>3. Agilent Technologies: Tips and Tricks Workshop on ICP-OES: Smarter Method Development</strong></h5>
<ul>
<li>Th, 22.2.2024, 19:00 (CEST)</li>
<li><a href="https://icpms.labrulez.com/webinar/3160">Registration</a></li>
</ul>
<p>Techniques on how to achieve the best sensitivity and detection limits through tuning techniques and strategies.</p>
<h5><strong>4. Agilent Technologies: See Through the Barrier: The Power of Agilent&#39;s Solutions for Raw Material Verification</strong></h5>
<ul>
<li>Fr, 23.2.2024, 19:00 CET</li>
<li><a href="https://icpms.labrulez.com/webinar/3354">Registration</a></li>
</ul>
<p>This talk will delve into the prowess of these Agilent Spatially Offset Raman spectrometers, emphasizing their capability to ensure material authenticity even through obstructions.</p>
<h5><strong>5. Agilent Technologies: Microplastic detection and quantification in the Cincinnati urban watershed using laser direct infrared (LDIR) chemical imaging system</strong></h5>
<ul>
<li>Tu, 27.2.2024, 21:30 (CEST)</li>
<li><a href="https://icpms.labrulez.com/webinar/3217">Registration</a></li>
</ul>
<p>Microplastic detection and quantification in the Cincinnati urban watershed using laser direct infrared (LDIR) chemical imaging system.</p>
<h5><strong>6. Agilent Technologies: Troubleshooting Tips and Tricks in Single Quad and Triple Quad ICP-MS</strong></h5>
<ul>
<li>Fr, 1.3.2024, 18:00 (CEST)</li>
<li><a href="https://icpms.labrulez.com/webinar/3143">Registration</a></li>
</ul>
<p>Most common tips and tricks on troubleshooting Agilent ICPMS, both single quad and triple quad.</p>


Webinars LabRulezICPMS Week 8-9/2024

<p><strong>Associate Professor <a href="https://lcms.cz/articles?search=Pavel+Po%C5%99%C3%ADzka"><strong>Pavel Pořízka</strong></a> is a member of Prof. Kaiser&#39;s research group, <em>Advanced Instrumentation and Methods for Materials Characterization</em>, at CEITEC BUT. Although the researchers mostly focus on the development of instrumentation and methodology in collaboration with industry, they have recently started to explore applications in biology thanks to a junior grant. In a GAČR-funded project entitled <em>Processes of laser ablation of soft tissues and subsequent development of laser-excited plasmas</em>, Pořízka and his team focused on the analysis of soft tissues using LIBS (Laser-Induced Breakdown Spectroscopy).</strong></p>
<h3><strong>The completed project was rated as excellent; it was also the first grant you led. Can you tell us more about it?</strong></h3>
<p>That was under a programme that I am happy to talk about and of which I was a successful applicant. It&#39;s a good thing that grant agencies provide individual calls for young scientists at the beginning of their careers, give them the opportunity to participate in a grant competition and gain valuable experience in managing larger projects. The grant we are talking about was announced by the Czech Science Foundation (Grantová agentura České republiky, GAČR) in the GAČR JUNIOR call (which gradually transformed into the larger JUNIOR STAR call). It&#39;s basically financial support for budding scientists. One of the conditions for applying for this grant was a long-term internship abroad, so I went to the University of Florida under a Fulbright grant.</p>
<p>Thanks to the junior grant, I had the opportunity to build my own team focusing only on the analysis of biological samples and to be its principal investigator. Until then, I was mainly a co-investigator on grants within our research group. As was the case of the previous grant awarded to my colleague Pavlina Modlitbová, which was again a grant for young researchers, TAČR – ZÉTA programme. This grant focused mainly on applied research, but it was in the field of biology, too.</p>
<h3><strong>What do you see as the biggest advantage of these programmes that support scientists at the beginning of their careers?</strong></h3>
<p>They literally get careers off the ground. Usually, if you haven&#39;t had a grant and you haven&#39;t been a principal investigator, you have little chance of getting a grant, which creates a kind of vicious circle. These programmes are supposed to disrupt that established system, and I&#39;m glad it&#39;s working that way. If there is even more intensive funding for grants for early-career scientists and, in particular, female scientists, that will only be a good thing. Thanks to this programme, we have received follow-up grants that have helped us to enter other scientific fields. It really is a great helping hand at the beginning of a career.</p>
<h3><strong>How does the process of selecting winning projects work?</strong></h3>
<p>Practically, it&#39;s a standardized procedure. The project is evaluated by a GAČR panel, where the committee and the opponents give their opinions on it. It is not simply included in the regular GAČR cycle with standard projects; it is judged outside of it. As a result, the project is evaluated independently of other project applications submitted by experienced scientists with a &quot;better&quot; CV. The h-index has long been crucial from the GAČR&#39;s point of view but this is also changing. At the beginning of one&#39;s career, one has a less impressive CV, and when one has to compete with someone who has a successful 20-year-long scientific career and has already received several research grants in the past, it is hard to get ahead.</p>
<h3><strong>Why did you take an interest in biological applications?</strong></h3>
<p>After returning from my internship abroad as part of my PhD studies at BUT, in our research group, we started to develop not only the development of instrumentation, which was historically strong here, but also the possible applications. This direction was interesting for several reasons. The most important factor was that it was a topic that I was personally interested in, especially in terms of the difficulty of analysing the sample itself, interpreting the data, and optimizing the parameters of the measurement setup. It was also something that pushed our collaboration towards developmental biology and, in time, perhaps clinical research. Thanks to this, we are collaborating with the Academy of Sciences and clinical departments at the University Hospitals in Hradec Králové and Ostrava. Last but not least, we have moved on to another grant and it has also brought us new contacts abroad.</p>
<p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/CEITEC_Pavel_Porizka_Diky_juniorskemu_grantu_jsme_ziskali_nove_projekty_i_zahranicni_spolupraci_Desticky_fe04570b77/CEITEC-Pavel-Porizka-Diky-juniorskemu-grantu-jsme-ziskali-nove-projekty-i-zahranicni-spolupraci-Desticky.jpg" alt="CEITEC: Pavel Pořízka: We have obtained new projects and foreign collaboration thanks to a junior grant"/></p>
<h3><strong>Can you highlight any foreign cooperation?</strong></h3>
<p>The strongest foreign cooperation in the field of biology is with the research group of Professor Andreas Limbeck from the Technical University of Vienna and Associate Professor Gabriela Kalčíková from the University of Ljubljana. We have a joint grant with both on the detection of microplastics in soft tissues and their influence and toxicity in these tissues. To sum it all up, this was a strategic and key decision for us – we have expanded our existing applications to include biology, and this has taken us further. We&#39;ve created a smaller team of about five or six students and two postdocs that are just focused on biological applications, whether we&#39;re talking about plant analysis, hard tissue (teeth and bones), or soft tissue (organs).</p>
<h3><strong>What is the potential of LIBS in the study of tumour tissues?</strong></h3>
<p>LIBS is a method of analytical chemistry designed for elemental analysis that is applied in a wide range of fields, including biology, but also, for example, geology. The method allows the distribution of elements on the surface of a prepared sample to be measured. In clinical research, we are investigating whether the LIBS method can be used to diagnose and support pathology and standard procedures currently used to refine the estimation of the extent of cancer in human skin. This is our main hypothesis. If we are able to refine the estimation of the area of diseased tissue, this could be used for diagnostic purposes during surgical procedures in the future. However, this remains a vision for now.</p>
<h3><strong>How far are you?</strong></h3>
<p>At the moment, we have already obtained dozens of samples from the hospital, and we have permission from the ethics committee to study them. The analysis of these samples is ongoing and we are preparing several scientific articles to present our research achievements. We also participate in international conferences where we receive positive feedback. This support convinces us that our work is worthwhile and that we should continue. We are focusing on combining different approaches from the perspective of correlative microscopy, which means combining classical microscopy and spectroscopy to use different techniques to obtain the most comprehensive information about the samples, i.e. how the chemical and structural composition changes depending on the disease being studied.</p>
<h3><strong>Where would you like to take the research in the near future?</strong></h3>
<p>We are moving forward and would like to submit another grant in the framework of Czech-Austrian cooperation in collaboration with the Technical University of Vienna. This will be a follow-up grant focusing on human tissue analysis and the study of skin cancer. But again, I have to stress that the beginning of this journey was the junior grant mentioned above which opened the door for us both in soft tissue analysis and international cooperation. Without this support, we would not have been able to successfully continue to discover new applications and expand the use of our method.</p>
<h3><strong>So you have analysed mouse and pig tissues first?</strong></h3>
<p>Clinical samples are very valuable to us, so we have model tissues – organs from laboratory mice – that we use to simulate human tissue. We don&#39;t measure clinical samples straight away, we first have to check if the system itself is working at maximum performance. In fact, when we analyse samples with LIBS, we use a powerful laser pulse to slightly heat and vaporise the material, creating the necessary analytical glowing plasma, thus practically destroying the sample. So the thin histological sections we get from the hospital are gone after the measurements.</p>
<p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/CEITEC_Pavel_Porizka_Diky_juniorskemu_grantu_jsme_ziskali_nove_projekty_i_zahranicni_spolupraci_lab_2289946f37/CEITEC-Pavel-Porizka-Diky-juniorskemu-grantu-jsme-ziskali-nove-projekty-i-zahranicni-spolupraci-lab.jpg" alt="CEITEC: Pavel Pořízka: We have obtained new projects and foreign collaboration thanks to a junior grant"/></p>
<h3><strong>Can we say that you are pioneers in measuring tumour tissue with LIBS?</strong></h3>
<p>I wouldn&#39;t say that at all. There are a few labs in the global community working on similar topics. We are slightly inspired by the success of our French colleagues at the University of Lyon. The LIBS method is not as established as competing methods. This is what makes the whole research more interesting, as we have to discover a lot of things ourselves. We are trying to move it closer to standard, routine use. So I wouldn&#39;t say pioneers, but I think we are making a significant contribution to making it more widely adopted and more competitive with other techniques.</p>
<h3><strong>Does the startup you founded in 2019, Lightigo, help you do that?</strong></h3>
<p>Extremely. It helps us develop systems that are not commercially available in the world, which was one of the most significant limitations of the whole method. This is something where we see ourselves quite at the forefront – on the one hand, we are developing the actual method of how to measure samples, and on the other hand, we are also able to develop systems in broad collaboration with our startup. This connection gives us the unique ability to adapt the system according to how it should measure, what performance it should have, which also makes it possible for us to move forward faster. This way, we are not dependent on any third-party instrumentation. However, it&#39;s more challenging in that we need broader funding.</p>
<p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/CEITEC_Pavel_Porizka_Diky_juniorskemu_grantu_jsme_ziskali_nove_projekty_i_zahranicni_spolupraci_2f1c1f9224/CEITEC-Pavel-Porizka-Diky-juniorskemu-grantu-jsme-ziskali-nove-projekty-i-zahranicni-spolupraci.jpg" alt="CEITEC: Pavel Pořízka: We have obtained new projects and foreign collaboration thanks to a junior grant"/></p>
<h3><strong>How demanding, financially speaking, is LIBS compared to competing methods?</strong></h3>
<p>The instrumentation and the low cost of the method are some of its biggest advantages. Our system is significantly cheaper than competing techniques, such as LA-ICP-MS, but lacks the sensitivity that seems to be essential in some applications. It is sufficient In applications such as the detection of heavy metals in teeth and bone. Although the LIBS method cannot be adopted in all applications, it can be used in many cases and achieve both financial and time savings. The limitations of the method were one of the aspects we addressed in the JUNIOR grant.</p>
<h3><strong>Are there any applications where you have already got into “hot water”?</strong></h3>
<p>There are some but that makes it all the more interesting to try. For example, we have not yet been able to detect iodine, which is used to stain the sample before computed tomography, i.e. before structural analysis. But we don&#39;t see it as a failure. It shouldn&#39;t sound like that, because if we can&#39;t do something now, it doesn&#39;t mean that we won’t be able to do it in the future with further development of instrumentation and measurement methodology.</p>
<h3><strong>What is the priority project now?</strong></h3>
<p>Right now, the three most important projects for us are the three GAČR projects and other TAČR projects in the TREND and NCK programmes. So we have a number of ongoing projects that involve the development of instrumentation and application in industry. However, we are able to manage such a broad scope because we have a group of talented students in our lab who help us significantly in moving forward quickly. They work on sub-topics and actively contribute to the development of our method during their studies.</p>
<p>Two GAČR projects are focused directly on biology, meaning we are able to follow our strategy. In the first project, we are starting our third year of work, and it concerns the detection of nanoparticles as indirect biomarkers of human tissue. With this method, we can specifically label the defined tissue, for example, breast cancer. Another priority for us is the detection of microplastics in soft tissues, where we combine LIBS, LA-ICP-MS and Raman spectroscopy for chemical analysis. We complement these spectroscopic and spectrometric methods with structural analysis by computed tomography from the laboratory of Assoc. Tomáš Zikmund, who is also part of Prof. Kaiser&#39;s research group. Our aim is to find out how the presence of microplastics affects the surrounding soft tissue and whether their presence can have any negative (toxic) effects. Trace elements are commonly found in plastics, including some toxic ones such as lead and cadmium. These substances can diffuse into the surrounding tissue and possibly affect it.</p>


Pavel Pořízka: We have obtained new projects and foreign collaboration thanks to a junior grant

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