An international team of scientists led by Tomáš Pluskal from the Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences (IOCB Prague) has introduced a new generation of software enabling scientists to analyze large volumes of data from mass spectrometry, a technique that separates chemicals by their weights. The open-source project MZmine provides a new window into the chemical space that surrounds us and lives within. The latest advances in <a href="http://mzmine.github.io/">MZmine 3</a> are now published in a <a href="https://www.nature.com/articles/s41587-023-01690-2">Nature Biotechnology</a> paper.
<h3>Challenges of biochemical analysis</h3>
Analytical chemists of the world, unite! This paraphrase could characterize the joint efforts of scientists across the globe, who, using the methods of mass spectrometry, strive to decipher and analyze the chemical composition of complex samples from various origins, especially in biological and clinical studies. Each individual sample can contain hundreds of thousands of different chemical compounds that scientists need to trace, quantify, and identify to understand their impact on human health or their ecological role.
<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/UOCHB_Robin_Schmid_Pocet_spustni_modulu_M_Zmine_v_letech_2017_2022_152c3eae85/UOCHB-Robin-Schmid-Pocet-spustni-modulu-MZmine-v-letech-2017-2022.jpg" alt="IOCB Prague/Robin Schmid: MZmine module runs in 2017–2022 (in millions)"/>
Even relatively small studies result in gigabytes of ‘raw’ data to be processed and interpreted. It is the processing, analysis, and comparison of a multitude of molecular data that constitutes some of the most challenging steps in biochemical analysis today. This is also a major bottleneck that limits the ability of scientists to expand knowledge and come up with exciting new discoveries.
<h3>Community-driven development</h3>
For this reason, a group of international scientists started in 2005 to develop the open-source software MZmine to aid the analysis of mass spectrometry data. The community developing this software has been co-established by Czech scientist <a href="https://pluskal.group.uochb.cz/en">Tomáš Pluskal</a>, who has been coordinating the project almost since its inception and is currently a group leader at IOCB Prague.
“The greatest strength of the MZmine project is the international community of experts that has formed around the project. At conferences, presentations on MZmine are always well received,” says Tomáš Pluskal about the project.
Robin Schmid from IOCB Prague and UC San Diego (CA, USA), one of the first authors of the paper, adds: “It&#39;s fantastic when we meet researchers from other countries for the first time and they tell us that MZmine and our support has saved their PhD thesis or projects. That&#39;s the best appreciation one can hope for.”
<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/UOCHB_Tomas_Bellon_Tomas_Pluskal_vlevo_a_Robin_Schmid_oba_z_UOCHB_92138f0c1d/UOCHB-Tomas-Bellon-Tomas-Pluskal-(vlevo)-a-Robin-Schmid-(oba-z-UOCHB).jpg" alt="IOCB Prague/Tomáš Belloň: Tomáš Pluskal (left) and Robin Schmid (both from IOCB Prague)"/>
The first version of MZmine has enabled scientists to automate the processing of datasets generated by analytical devices at an unprecedented scale. The second generation of MZmine, released in 2010, made the project more widely known and led to the formation of a worldwide community of researchers using the software and continuing to expand its functions with additional modules and applications. The publication introducing the second generation of MZmine has since collected more than 2,200 citations in scientific articles and the tool itself has been used to process millions of different measurements.
<h3>Third generation</h3>
The newest MZmine 3 brings several major improvements. Whereas the previous version allowed scientists to analyze hundreds of samples in a matter of days, the new generation makes it possible to process thousands of samples per hour. Besides vastly accelerating data processing, the new version of the software can also be used, for the first time, to link different data types, especially time-resolved and imaging data.
<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/UOCHB_Nature_Biotechnology_M_Zmine_open_source_komunitni_projekt_pro_integrativni_zpracovani_dat_LC_IMS_MS_a_IMS_MS_6d9b3759d1/UOCHB-Nature-Biotechnology-MZmine-open-source-komunitni-projekt-pro-integrativni-zpracovani-dat-LC-IMS-MS-a-IMS-MS.jpg" alt="IOCB PRague/Nature Biotechnology: MZmine, an open-source community project for integrative LC–IMS–MS and IMS–MS data processing"/>
This opens up opportunities for researchers to more easily analyze and interpret complex biological samples. MZmine is a tool to investigate the causes and mechanisms of diseases, detecting useful clinical biomarkers for diagnostics and identifying chemicals in the environment. This includes previously unknown chemical structures, which might prove valuable for the discovery and development of new drugs for medical applications.
The third generation of MZmine was announced in a paper prepared, besides Tomáš Pluskal as the corresponding author, by the first authors Robin Schmid (IOCB Prague and UC San Diego), and Steffen Heuckeroth and Ansgar Korf (both from University of Münster, Germany), joined by over three dozen other contributors from around the world.
“MZmine has established itself as a trusted tool for mass spectrometry researchers over the past decade. Its modular framework has fostered community participation in the development of the MZmine code, leading to significant advancements featured in the newly released MZmine 3,” says Ansgar Korf of University of Münster.
The development of the MZmine project has been supported by the Czech Science Foundation (project No. 21-11563M).
<ul>
<li>Literature for using the MZmine software <a href="https://lcms.labrulez.com/library?search=MZmine">in the LabRulezLCMS library</a></li>
<li>Literature for using the MZmine software <a href="https://gcms.labrulez.com/library?search=MZmine">in the LabRulezGCMS library</a></li>
</ul>

A breakthrough in big data processing helps trace chemicals in complex mixtures

<a href="https://icpms.labrulez.com/products/1086">USP-ID</a>, delivered by <a href="https://icpms.labrulez.com/companies/298">Mestrelab Research</a>, makes powerful qNMR analysis easy. This software allows lab scientists to identify chemicals and impurities quickly. Beyond automatic identification, quantification, and labeling, USP-ID improves spectral interpretability with quantum-mechanical models based on USP reference standards and smart analytics. USP-ID also resolves overlapping peaks, even when no single signal is distinct. 
Michael Levy, SVP of Digital &amp; Innovation at USP, said: “Mestrelab’s delivery of USP-ID within Mnova brings this powerful software to a valuable network of analytical chemistry customers. The joint solution makes qNMR analysis more accessible to all. We are excited to unlock the value provided by this partnership.” 
Santiago Dominguez, CEO of Mestrelab, said: “NMR is a unique analytical technique from the perspective of the richness of information it provides and, with its evolution towards benchtop instruments, it has the potential to deploy in many use cases beyond its traditional research applications. USP-ID is an extremely powerful technology which turns benchtop NMR into an accessible technique for quality control and mixture analysis applications. We are very excited by this integration with Mnova, which enhances the power and applicability of our tools and opens new markets and solves difficult to tackle problems and look forward to continue to develop what we see as a strategic partnership with USP.”
To learn more about USP-ID, delivered by Mestrelab, and to add USP-ID as an application within Mnova, please visit <a href="http://www2.mestrelab.com/l/271522/2024-03-25/3nwsnf">mestrelab.com/software/usp-id/</a> or <a href="https://www.usp.org/products/qnmr-mestrelab">usp.org/products/qnmr-mestrelab</a>.
*The integration of USP-ID into Mnova does not imply approval, endorsement, or certification by USP of Mestrelab products, nor does it imply that Mnova is necessarily the best available product for the purpose or that any other brand or product was judged to be unsatisfactory or inadequate. As a standard setting organization, USP avoids conflicts of interest that interfere or appear to interfere with its impartiality and objectivity.
<blockquote>
About USP
</blockquote>
<blockquote>
USP is an independent, scientific nonprofit organization focused on building trust in the supply of safe, quality medicines. For over 200 years, USP has worked to build trust where it matters most: in the world&#39;s medicines, dietary supplements, and foods. While USP’s public health mission has remained unchanged for over 200 years, the global healthcare landscape has been anything but static. Advances in analytical methods, manufacturing processes, and digital innovations are changing the science of how medicine quality is assessed and maintained. USP’s portfolio of solutions addresses quality assurance, builds a stronger medicines supply chain, enhances regulatory predictability, and helps manufacturers distribute quality medicines, dietary supplements, and foods.
</blockquote>
<blockquote>
About Mestrelab
</blockquote>
<blockquote>
MESTRELAB RESEARCH, with nearly two decades of expertise, specializes in advanced analytical chemistry solutions. Our comprehensive toolset supports pharmaceutical and biopharmaceutical industries, addressing Research and Development (R&amp;D) and Quality Control (QC) needs, including NMR, LC/GC-MS, and optical spectroscopy data analysis. Committed to streamlining workflows and automating processes, we empower customers to prioritize scientific innovation over routine tasks. Collaborating closely with industry leaders, we take pride in creating cutting-edge tools seamlessly integrated into workflows, ensuring an efficient experience for our valued customers. 
</blockquote>

The U.S. Pharmacopeia (USP) and Mestrelab Research, S.L. (Mestrelab), are pleased to announce they have entered into a collaboration to deliver USP-ID, through Mestrelab’s Mnova platform.

Mnova Web eliminates the need for complex software installations and hardware dependencies. Users can now access Mnova’s advanced NMR processing and analysis tools directly through their web browsers. This cloud-based solution ensures that scientists can work from anywhere, at any time, on any device with just an internet connection, fostering greater flexibility and productivity.
<blockquote>
<h4><a href="https://bit.ly/3S2nRQx">Register for Mnova Web and get a 10-day free trial!</a></h4>
</blockquote>
Mnova Web provides the same capabilities for processing, analyzing, and reporting as Mestrelab’s flagship, Mnova NMR. Designed with the user in mind, Mnova Web provides an intuitive interface that simplifies complex NMR data analysis tasks. New users can quickly learn to navigate the platform, while experienced Mnova users will find the transition from the desktop version seamless.
<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Mestrelab_Research_Introducing_Mnova_Web_A_New_Era_for_NMR_Data_Analysis_Mnova_Web_Main_Image_2_c9c836bdcf.jpg" alt="Mestrelab Research: Introducing Mnova Web: A New Era for NMR Data Analysis."/>
With Mnova Web, Mestrelab offers the benefits of a SaaS model combined with Mnova NMR plugin features, achieving a perfect combination for those seeking a versatile tool to analyze NMR data.
<blockquote>
<h4>Watch the introduction video above or on <a href="https://youtu.be/8qf8leGU-sY">YouTube</a>.</h4>
</blockquote>
<h4>Key Benefits:</h4>
<ul>
<li>Global accessibility with just an internet connection.</li>
<li>Always work with the latest Mnova NMR version.</li>
<li>No installation or updates required.</li>
<li>Minimal hardware requirements.</li>
<li>OS independence and web-browser flexibility.</li>
<li>Enhanced data safety with company-wide isolation.</li>
</ul>
<h4>Main Features:</h4>
<ul>
<li>Mnova NMR plugin capabilities.</li>
<li>Compatibility with various NMR data formats and instruments.</li>
<li>User-friendly interface.</li>
<li>Cloud storage and data sharing.</li>
<li>Easy license and user management.</li>
</ul>
<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Mestrelab_Research_Introducing_Mnova_Web_A_New_Era_for_NMR_Data_Analysis_Mnova_Web_features_89d2a36e4a.jpg" alt="Mestrelab Research: Mnova Web features."/>
<blockquote>
<h4>Mnova Web is now available to users worldwide. To learn more about Mnova Web, <a href="https://bit.ly/4cWJ9a7">visit the product page</a>.</h4>
</blockquote>
<h4>A Word from Mestrelab Research</h4>
&quot;For organizations where deployment and updating of Mnova is an issue, Mnova Web provides a useful alternative. For the user, the experience is essentially the same as with desktop Mnova, so there is no real compromise in most situations,&quot; said Gary Sharman, Senior Scientific Director at Mestrelab Research.
<h4>About Mestrelab Research</h4>
Mestrelab Research is a leading provider of scientific software solutions, specializing in NMR, LC/GC-MS, and other analytical chemistry applications. With a commitment to innovation and excellence, Mestrelab Research serves the global scientific community, empowering researchers to achieve their goals with state-of-the-art tools and technologies.
<blockquote>
<h5><a href="https://icpms.labrulez.com/companies/298">Mestrelab Research profile on LabRulez</a></h5>
</blockquote>

Introducing Mnova Web: A New Era for NMR Data Analysis

<h4>Description and use:</h4>
These reference materials are aqueous calibration solutions of individual elements and ions with certified/assigned concentration value in the range from 1 mg/l to 10 g/l or 1mg/kg to 10g/kg (m/m) and aqueous calibration solutions of combinations of elements and/or ions with certified/assigned concentrations at various levels relevant to particular analytical requirements. They can be used by analytical techniques analysing aqueous solutions such as atomic spectrometry (<a href="https://icpms.labrulez.com/library?instrumentationItems=85">AAS</a>, AFS, <a href="https://icpms.labrulez.com/library?instrumentationItems=84">ICP-OES</a>, <a href="https://icpms.labrulez.com/library?instrumentationItems=83">ICP-MS</a>), molecular absorption spectrometry, ion chromatography and some selected electroanalytical methods.
<h4>Starting primary substances and other applied materials:</h4>
Metals or compounds (in mass calculated from the content of the certified component and a target volume of the batch) are used as starting materials for the production of these RM. High purity metals with a declared assay of minimum 99.95 % are preferred and compounds of a defined and constant stoichiometry and declared assay and/or impurities content are used when a suitable metal is not available [1, 2]. The supplier of primary substances must comply with ISO 17034 [3], namely to employ a certified Quality Management System. Each supply of the primary substance must be accompanied with complete documentation, including an identification of sources and treatment, assay and impurity contents. As required by this Guide, the supplier’s data are verified by the CRM producer and by other subcontracted accredited laboratories (e.g. trace metal impurities by spectroscopic methods such as ICP-AES, ICP-MS, AAS, the assay by primary gravimetric or volumetric methods).
Acids (prepared by sub-boiling distillation), other ultrapure chemicals (ammonium hydroxide, hydrogen peroxide, etc.) and deionised water with a resistivity 18 MΩ.cm are further applied in the (C)RM preparation. Their impurity contents are regularly monitored. They are generally negligible (~ 1 μg/l) as compared with the concentration of the certified/assigned constituent.
<h4>Weighing, volume and temperature measurement:</h4>
A class 1 electromechanical analytical balances with a valid verification is used to weigh the primary substances. A performance of this balance is regularly controlled by the Czech Metrology Institute. Mettler weights class F1 (5 g and 100 g) are used for an internal calibration control. Two calibrated mercury or alcoholic thermometers 0 – 50 °C (with a scale division by 0.1 °C), regularly calibrated by authorized institutions are used for the temperature measurement.
All volumetric vessels used (flasks, pipettes, burettes) are of Accuracy Class 1, calibrated by their producers and delivered with a relevant certificate. The calibration of all labware is regularly checked.
<h4>Coding and packaging:</h4>
(C)RMs are delivered in amber HDPE bottles or amber glass bottles whenever an interaction of the analyte with HDPE may be suspected (e.g. mercury, precious metals). Prior to filling, the bottles and caps are leached by HCl (5% v/v) for a longer period, washed repeatedly with deionised water and thoroughly dried. The bottle filled with (C)RM is hermetically closed with a polypropylene screw cap and tightened with parafilm immediately after filling and sealed into reclosable aluminium bag or PE foil. The bottle is labelled with a resistant plastic label containing all data as required by (C)RM standards, i.e. (C)RM and batch codes, volume of the packed unit, type of the matrix, producer identification and contact data, further data and warning symbols when required by specific regulations [4, 5].
<h4>Homogeneity and stability:</h4>
The (C)RM are considered homogeneous due to their physico-chemical character (diluted solutions) and thus a detailed homogeneity testing is not required. This fact is supported by a long-term experience of the producer and other recognized producers of similar materials. In compliance with a recommendation of ISO 17034, homogeneity testing is performed (as prescribed in ISO Guide 35) at randomly chosen solutions and evaluated by ANOVA. 
An assumption of stability and the consequent expiration period is based on both over 20 year experience with the preparation of similar RMs and a test of possible instability factors. These factors are of general (e.g. water evaporation by regular weighing of the filled bottle) and specific character (e.g. adsorption and desorption of the particular analyte on the walls of the bottle, precipitation, etc.).
Along with these tests the content of the certified/assigned constituent in the bottle is compared (at least twice during the validity period) with that of a newly prepared batch and/or a corresponding (C)RM form other producers. For these comparisons, both primary analytical methods (gravimetry, titrimetry) and some instrumental methods (ICP-OES, AAS) working in the regime of maximum precision (the application of internal standard, bracketing technique etc.) are used. For selected analytes, an accelerated isochronous stability test (in the temperature range of -20 °C to +40 °C) is realized. Based on these tests, transport conditions for a particular (C)RM are defined.
<h4>Certification, certified and assigned value and their uncertainties:</h4>
The concentration value of CRM/RM are certified/assigned on the basis of gravimetric preparation (refering to ISO Guide 35), i.e. on weighing and volume measurement [6]. They are calculated from an assay of the certified constituent in the primary substance, declared by its supplier and duly verified by the CRM producer. The certified/assigned concentration (m/v) and its uncertainty are expressed in g/l (alternatively in mg/kg) at a temperature of 20 ± 0.1 °C.
The uncertainty of the certified/assigned values is estimated in compliance with ISO and EURACHEM methodologies [7, 8]. It combines the calculated standard uncertainties of the individual CRM/RM preparation steps with an expert estimate of the standard uncertainty of the assay of the certified constituent in the primary substance, usually a dominant contribution. The expanded combined uncertainty calculated using coverage factor k = 2 is expressed as a two-sided half-interval by one significant figure, with the certified value given by the same number of digits.
The particular certified values and uncertainties, mostly at a level of 0.2% (rel.), are specified in the Certificate together with the expiry terms and other relevant information.
The particular assigned values and uncertainties, mostly at a level of 0.5% (rel.), are specified in the Identification sheet together with the expiry terms and other relevant information.
The certified/assigned analyte concentration and its uncertainty is further experimentally verified by means of primary and instrumental analytical methods [9]. However, the results received are not used in the calculation of the certified/assigned value and serve only for the confirmation that this value is true.
<h4>Traceability and quality assurance:</h4>
Direct traceability to SI unit for the weight (1 kg) is secured by using a primary substance within comprehensively verified content of the analyte constituent and by gravimetric method of preparation. This traceability is for each produced batch of (C)RM further confirmed by analytical data acquired from the determination of certified analyte with validated primary and instrumental analytical methods. Only internationally accepted references (SRM NIST, TraceCERT etc.) are used.
The producer operates a certified quality management system ISO 9001 [10] and is accredited according to ISO 17034 [12].
Control analytical laboratory of the producer is accredited according to ISO/IEC 17025 [11].
<h4>Storing and instructions for use:</h4>
This (C)RM must be stored in the original closed bottle (in an upright position) between 5 °C and 30 °C, away from any strong light sources (e.g. sunshine, UV lamp). The producer guarantees declared life time (shelf life) and expiration time (period of validity) provided (C)RM is properly stored and professionally handled. The temperature of the bottle with (C)RM must be 20 ± 0.5 °C before every use. After use, the bottle must be immediately tightly capped. It is recommended to tighten the screw cap with parafilm Do not pipette from the bottle. Do not return removed aliquots to bottle. The user should differentiate between the life time (shelf life) of the particular (C)RM (usually 5 years from the date of production) and expiration time (never more than 24 months from the first opening of the bottle). Both values are presented in the Certificate and Identification sheet. It is necessary to indicate on the Certificate/Identification sheet the date of the first opening of the bottle or aluminium bag and the expiration time, which depends on the date of the first opening. It is necessary to indicate the expiration time on the label of the bottle too.
It is not recommended to use the standard solution when the bottle contains less than 10 % of the solution. Therefore, in case of opaque bottle, it is important to indicate the amount of the solution used, e.g. on the label.
Transpiration through amber HDPE bottles (losses of the solution mass resulting in a gradual increase in the analyte mass fraction) was not observed. It is the producer’s experience that the loss of vapour phase occurs solely around the screw cap of the bottle which is not airtight. Therefore, it is recommended to cover the screw cap and the neck of the bottle with parafilm layer after each opening and put the bottle into the reclosable aluminium bag, if it is delivered in.Safety regulations for transportation, storage, and use of this (C)RM are specified in the respective Safety Data Sheet.

Detailed information about the production of aqueous calibration solutions Astasol®

Water systems are an essential part of any modern laboratory where reliable water purification is required. Laboratory water plays a crucial role in scientific research, as its quality directly impacts the results of experiments, analyses, and production processes. Let’s explore the importance of high-quality water in laboratories, the types of Watrex water systems, and their applications in the laboratory environment.<h3>The Importance of Water Quality in the Laboratory</h3>Water is used in a wide range of laboratory operations, from preparing solutions and media, to washing laboratory glassware, and in specific analytical methods such as HPLC (High-Performance Liquid Chromatography), ICP-MS (Inductively Coupled Plasma Mass Spectrometry), or PCR (Polymerase Chain Reaction). High-quality water is essential for achieving reproducible and accurate results, as any contamination can lead to errors in experiments, resulting in loss of time, resources, and sometimes even damage to sensitive equipment.<h3>Classification of Laboratory Water</h3>Laboratory water is typically classified into several grades based on its level of purity:1. Deionized Water (DI Water): This water has been treated using mixed-bed ion exchangers, which remove most ionic contaminants. It is often used in less sensitive applications, such as washing glassware and preparing certain solutions.2. Reverse Osmosis Water (RO Water): This type of water is purified through reverse osmosis, a process that removes up to 99% of dissolved salts and organic substances. RO water is suitable for many laboratory applications but may require further purification for higher purity in some cases.3. Ultrapure Water (UP Water): This is the highest grade of water purity, achieved through a combination of methods including deionization, reverse osmosis, ultrafiltration, and UV sterilization. UP water is essential for applications where even minimal contamination could affect results, such as in liquid chromatography, molecular biology, or pharmaceutical research.<h3>Types of Watrex Water Systems for Laboratories</h3><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products?category=291&amp;manufacturerItems=93&amp;search=rowapur">SCI-AQUA ROWAPUR</a>: SCI-AQUA ROWAPUR systems are simple and economical, making them ideal for laboratories. They use reverse osmosis to purify water, removing a wide range of contaminants including ions, organic substances, and bacteria. These systems are suitable for laboratories with higher water quality requirements and are often used as the first step in the water purification process.2.<a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/1278"> SCI-AQUA ULTRAPUR</a>, SMART PUV and SMART PLUS N: These systems combine several water purification methods to achieve maximum purity. In addition to removing ions and organic substances, they also eliminate bacteria, endotoxins, DNases, and other contaminants. These systems are crucial for applications requiring the highest possible water purity.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Watrex_Water_purification_systems_8810a2c48a.jpg" alt="Watrex: Water purification systems" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Watrex_Water_purification_systems_8810a2c48a.jpg 245w," sizes="100vw" width="2286" height="1130"><h3>Installation and Maintenance of Water Systems</h3>Proper installation and maintenance of water systems are essential for ensuring their long-term reliability and efficiency. The Watrex specialized service team offers comprehensive services, including regular maintenance, rapid filter replacement, system calibration, effectiveness verification, and overall equipment functionality checks. Additionally, we provide extensive training for laboratory personnel to ensure that the systems are used and maintained correctly. With Watrex's expert approach and quick response, you can be confident that your laboratory water systems will always be in optimal condition, ready to support your research.<h3>Conclusion</h3>With increasing demands for accuracy and reliability in scientific results, the importance of highquality water systems for laboratories will continue to grow. The choice of the right system depends on the specific needs of the laboratory, the required water purity, and the available financial resources. Rely on Watrex water systems to ensure that your results are always accurate and reliable.For more information or a non-binding quote, please contact us at watrex@watrex.com or visit our website at www.watrex.com

Clean Water for Quality Results: Rely on Our Water Systems

Multielement certified material in nitric acid and hydrofluoric acid. CRM Mix 23 elements 100mg/l ea., in 5% Nitric acid + 0.2% Hydrofluoric acid, HDPE, 100 ml.<h5>All variations</h5><ul><li>30 ml - Contact us for a price</li><li>50 ml - Contact us for a price</li><li>100 ml - Contact us for a price</li><li>250 ml - Contact us for a price</li><li>500 ml - Contact us for a price</li><li>3 x 30 ml - Contact us for a price</li></ul><h4>Intended use:</h4>For calibration and validation of analytical methods analysing aqueous solutions such as atomic spectrometry (AAS, AES, ICP-OES, ICP-MS), molecular absorption spectrometry and selected electroanalytical methods.<ul><li>Product code: AN9094MFN</li><li>Concentration: 100 mg/l</li><li>Matrix: HNO3 + HF</li><li>Number of elements: Multi-element Type: CRM</li><li>Volume: 100 ml</li><li>Analytes: As, Be, Ca, Cd, Co, Cr, Cu, Fe, Li, Mg, Mn, Mo, Ni, P, Pb, Sb, Se, Sn, Sr, Ti, Tl, V, Zn</li><li>Expiry: 12 months</li><li>Matrix concentration: 5 % + 0.2 %</li><li>Package: HDPE</li><li>Shelf life: 36 months</li></ul><h4>Starting primary compounds and theirs purities (%):</h4>As 99.9999; BeO 99.98; CaCO3 99.999; Cd 99.999; Co 99.998; Cr(NO3)3 . xH2O 99.99; Cu 99.999; Fe 99.998; Li2CO3 99.999; Mg 99.98; Mn 99.98; Mo 99.95; Ni 99.995; NH4H2PO4 99.999; Pb 99.999; Sb 99.999, Se 99.995; Sn 99.999; SrCO3 99.994; Ti 99.99; TlNO3 99.9995; NH4VO3 99.95; Zn 99.99<h4>Matrix:</h4>5% HNO3 (v/v), prepared from sub boil distilled HNO3 (ANALPURE®), 0.2% HF (v/v) prepared from sub boil distilled HF (ANALPURE®) and ultrapure demineralized water (resistivity ≥ 18 MΩ.cm, 0.22μm filtered).<h4>Certification and traceability:</h4>This CRM is certified on the basis of gravimetric preparation. This procedure also ensures a direct traceability to SI unit – kg. Certified values, uncertainties and traceability were further verified by primary analytical methods (gravimetric, titrimetric) as well as by instrumental methods (AAS, AES, ICP-OES) calibrated with independent reference solutions (e.g. SRM NIST, TraceCERT, in-house solid and liquid CRMs). Analytical methods and references used are listed in the following table.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Analytika_Certification_and_traceability_ASTASOL_AN_9094_MFN_80eb36f0b2.jpg" alt="Analytika: Certification and traceability ASTASOL AN9094MFN" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Analytika_Certification_and_traceability_ASTASOL_AN_9094_MFN_80eb36f0b2.jpg 206w," sizes="100vw" width="1182" height="895"><h4>Trace impurities in bottled solution (in mg/l):</h4>Determination of trace impurities was performed by AAS, ICP-OES and ICP-MS. Impurity levels are supplied only for information of the user and should not be used as calibration data.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Analytika_Trace_impurities_in_bottled_solution_in_mg_l_ASTASOL_AN_9094_MFN_7ed86f33d1.jpg" alt="Analytika: Trace impurities in bottled solution (in mg/l) ASTASOL AN9094MFN" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Analytika_Trace_impurities_in_bottled_solution_in_mg_l_ASTASOL_AN_9094_MFN_7ed86f33d1.jpg 245w," sizes="100vw" width="1182" height="613"><h4>Homogeneity and stability:</h4>It has been demonstrated that this CRM is homogeneous and its stability is guaranteed during the whole shelf life provided the solution it kept under conditions presented below.<h4>Storing and instruction for use:</h4>This CRM must be stored in the original closed bottle between 5 – 30 °C. The producer guarantees a declared shelf life and expiration time provided the CRM is properly stored and professionally handled. The temperature of the solution must be 20 ± 0.5 °C before every use. It is necessary to indicate on this certificate and the label the expiration time, which depends on the date of the first time the aluminium bag was opened. After use, the bottle must be immediately tightly capped, and it is recommended to put it back into the reclosable aluminium bag. It is not recommended to use the standard solution when the bottle contains less than 10 % of the solution. Therefore, in case of non-transparent bottle, it is important to indicate the amount of the solution used, e.g. on the label. Do not pipette from the bottle. Do not return removed aliquots to bottle.<h4>Note:</h4>Detailed information about the production, homogeneity, stability, coding, characterization and storing of this CRM are described in the document “Detailed information about the production of aqueous calibration solutions ASTASOL®“ which is available for download on the website <a target="_blank" rel="noopener noreferrer" href="https://www.analytika.net/">www.analytika.net</a>.&nbsp;

Multielement certified material (Mix 23 elements)

The TRILAB DeltiQ 2, 3D printer from the Brno-Hradec Králové company TRILAB is a high-quality 3D printer from the so-called pro-sumer segment of the desktop 3D printer category. It is a printer completely developed by TRILAB, designed and built only from high-end components. Its hardware and software is adapted and tuned for short, but also multi-day prints even without the presence of an operator. Thanks to the remote-control software and the built-in camera with lighting, the user is constantly in control of printing. Also in the case of ambiguity, question or problem, the printer is immediately remotely diagnosed by the TRILAB service team.
Thanks to the technical and application support of the TRILAB team and also thanks to the many years of experience of the two main partners of TRILAB in the field of science and research, where Dr. Vojtěch Tambor is originally the leading researcher in the laboratory of the Center for Biomedical Research (CBV) of the University Hospital HK and Dr. Michal Boháč is a former director of Bruker s.r.o., every scientific customer is always perfectly professionally secured and can thus focus only on solving their own challenges and projects.
Thanks to practical experience with placing 3D printers in research laboratories, TRILAB also knows very well that the DeltiQ 3D printer does not only allow its owners to save time and money in producing things that are familiar and hard to reach, but also and above all to create and quickly test completely new things, not yet discovered. In addition, it allows them to be pampered by the quality of the printing surface, spatial accuracy, huge print volumes or even just the grace of delta kinematics movements. In addition, the customer does not have to buy the printer as an investment, but can rent it or cleverly buy it under an initial operating lease with a possible subsequent purchase. This not only divides the financial costs of its acquisition over a longer period, but also avoids possible lengthy approval processes for investment purchases.
The DeltiQ 3D printer will become a great help in your research project. Whether it&#39;s simple holders or specialized components, with a 3D printer you can save not only most acquisition costs, but also a lot of time spent looking for a suitable tool. In addition, you can create tools that you cannot buy as they do not exist! And besides tools, you can also create your own prototypes, products or their models and replacements.
<h3>The story of <a href="https://www.nenovision.com/">NenoVision</a>: Thanks to 3D printing, our microscope can be touched safely</h3>
NenoVision is a start-up originating from the Central European Institute of Technology CEITEC and is one of the incubated companies in the South Moravian Innovation Center JIC INMEC. They are proud that their LiteScope microscope is the only one in the world that can combine data from an electron microscope and an atomic force microscope in detail and assemble them into 3D models. It literally opens up a new dimension of research.
<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Trilab_Neno_Vision_mikroskop_1_6b79421014/Trilab-NenoVision-mikroskop-1.jpg" alt="TRILAB: NenoVision - model of LiteScope microscope printed on the TRILAB DeltiQ printer"/>
The company found the application of 3D printing in solving the problem of how to enable the &quot;touch&quot; of the microscope to partners, customers and the professional public: &quot;LiteScope normally works in a controlled environment, moreover in a vacuum, and it is a sensitive and very expensive device. Therefore we or our distributors cannot normally carry it to all events and exhibitions, nor provide it to our partners for tests for insertion into their machines,” explains Jan Neumann, the owner and CEO of NenoVision.
<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Trilab_Neno_Vision_mikroskop_2_8d96758735/Trilab-NenoVision-mikroskop-2.jpg" alt="TRILAB: NenoVision - model of LiteScope microscope printed on the TRILAB DeltiQ printer"/>
Machining the individual components of the microscope itself is so expensive that even making a copy of the instrument without &quot;living&quot; components does not make sense. In the end, 3D printing proved to be an elegant solution: “Since the complete 3D model for production was already ready, it was enough to prepare and print it on a TRILAB DeltiQ printer and the model of the device in perfect quality and accuracy was born. In this way, it can be easily reproduced and shown to customers and the public at a fraction of the normal cost,” adds Jan Neumann. 
<h3><a href="https://www.biocev.eu/en">BIOCEV</a> story: Own online nanospray built in a few days?</h3>
The story of <a href="http://peterslab.org">Dr. Petr Novák</a> from BIOCEV shows the second group of 3D printing options. Building something that does not exist, that you cannot buy, and you know what it should look like and you need it. Dr. Novák&#39;s team happened to be in exactly the same situation. Commercially available nanosprays did not meet the requirements not only in terms of compatibility with available spectrometers, but also in terms of real sensitivity, essential for measurement. That&#39;s why the &quot;Do it yourself&quot; mode came into play. Thanks to the clever use of 3D printing, a nanospray was created, which has ncomparably higher sensitivity and operator comfort compared to all commercial devices available on the market. 
<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Trilab_BIOCEV_online_nanosprej_1_ac1e93326c/Trilab-BIOCEV-online-nanosprej-1.jpg" alt="TriLab: BIOCEV - online nanospray"/>
<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Trilab_BIOCEV_online_nanosprej_2_ba9dbfde99/Trilab-BIOCEV-online-nanosprej-2.jpg" alt="TriLab: BIOCEV - online nanospray"/>
<h3>The story of the MALDI-TOF plate suitable not only for affinity chromatography</h3>
As part of the projects of AffiPro, a spin-off company under BIOCEV Prague, it has been running for several years under the leadership of Dr. Petr Novák and Dr. Petr Pompach for the development of clinical applications of affinity chromatography on MALDI-TOF spectrometry, for example MALDI Biotyper devices, by patented application of various antibodies to MALDI plates using the so-called soft ion landing technology. Although this is a technology that is just beginning and commercial use is yet to come, they already have several very interesting surfaces on their own chips in the laboratory, which will be interesting in the future not only for clinical and veterinary, but also for military screening. And thanks to the use of 3D printing technology, they have the opportunity to print not only different surfaces and shapes, but also to use different materials on MALDI chips and thus, for example, increase the sensitivity and detection limits of the method. 
<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Trilab_Affi_Pro_MALDI_TOF_desticka_836e1e69b7/Trilab-AffiPro-MALDI-TOF-desticka.png" alt="TriLab: AffiPro/BIOCEV - MALDI-TOF chip for affinity chromatography"/>
The original article <a href="https://pubs.acs.org/doi/pdf/10.1021/acs.analchem.0c01737">Three-Dimensional Printed Target Plates for Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry ke stažení.</a>

TRILAB 3D printing solutions and DeltiQ 2 printers are in the lab at home

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The Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences (IOCB Prague) is a leading scientific institution in the Czech Republic, recognized internationally. Its primary mission is basic research in the fields of chemical biology and medicinal chemistry, organic and material oriented chemistry, chemistry of natural compounds, biochemistry and molecular biology, physical chemistry, theoretical chemistry, and analytical chemistry. 

Ústav organické chemie a biochemie AV ČR

Mestrelab Research is a scientific software company with nearly two decades of expertise, specializing in providing advanced solutions in the field of analytical chemistry. As a fast-growing company, we have doubled in size over the past five years, now boasting over 90 employees spread across headquarters in Santiago de Compostela (Spain), as well as offices in Europe, Asia, and the USA.

Mestrelab Research

Analytika is a Czech company that offers and produces certified reference materials (CRM) and (ultra)pure chemicals for quality control and quality assurance in laboratories, including accredited laboratories.

Our portfolio also includes pipettes and tips, digestors, PFA labware and other equipment for analytical laboratory and trace analysis.

ANALYTIKA

Czech developer and producer of exceptional quality FDM 3D printers and original solutions based on delta kinematics.

TriLab

Watrex Praha je přední český výrobce a distributor systémů a příslušenství zejména pro kapalinovou chromatografii. Distribuujeme produkty mnoha chemických firem a máme vlastní řadu systémů za rozumnou cenu.

Multielement certified material (Mix 23 elements)

Clean Water for Quality Results: Rely on Our Water Systems

Detailed information about the production of aqueous calibration solutions Astasol®

Introducing Mnova Web: A New Era for NMR Data Analysis

The U.S. Pharmacopeia (USP) and Mestrelab Research, S.L. (Mestrelab), are pleased to announce they have entered into a collaboration to deliver USP-ID, through Mestrelab’s Mnova platform.

A breakthrough in big data processing helps trace chemicals in complex mixtures

TRILAB 3D printing solutions and DeltiQ 2 printers are in the lab at home

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