News from LabRulezICPMS Library Weeks 27-29, 2024

Our Library never stops expanding. What are the most recent contributions to LabRulezICPMS Library in the weeks Weeks 27-29, 2024? Check out new documents from the field of spectroscopy, especially ICP/MS techniques!

👉 SEARCH THE LARGEST REPOSITORY OF DOCUMENTS ABOUT ICPMS AND RELATED TECHNIQUES

👉 Need info about different analytical techniques? Peek into LabRulezLCMS or LabRulezGCMS libraries.

1. Agilent Technologies: Agilent ICP-MS IntelliQuant Analysis

• Technical Overview: An overview of QuickScan, IntelliQuant, and Star Rating

Introduction: Introduced in Agilent ICP-MS MassHunter version 4.6, IntelliQuant for ICP-MS provides an automated semiquantitative analysis for every sample. Calibration and background correction are automatically made with no user intervention, and data is presented in an easily understood periodic table heat map format and a comprehensive data table.

IntelliQuant is possible because a QuickScan can be performed when measuring each sample. The optional two second QuickScan acquires a complete mass spectrum of the entire measurable mass range, facilitating semiquantitative and Total Matrix Solids (TMS) calculations of every sample.

TMS levels are calculated from the IntelliQuant data. Similar to Total Dissolved Solids (TDS), TMS is the sum of the key matrix elements in each sample. Included in the TMS calculation are the elements typically considered to contribute to matrix effects, such as ionization suppression and matrix deposition on interface cones and lenses. Gas elements, including elements in acids such as HCl and HNO₃ , do not cause appreciable matrix effects in ICP-MS, so they are excluded from the calculation.

2. Agilent Technologies: Analysis of Elemental Impurities in Synthetic Oligonucleotides by ICP-MS In compliance with USP <232>/<233> and ICH Q3D(R2)/Q2(R1)

• Poster - ASMS 2024

Introduction: Synthetic oligonucleotides are short chains (oligomers) of deoxyribonucleic acid (DNA) or ribonucleic acid (RNA) molecules. They are used in applications such as polymerase chain reaction (PCR) tests, DNA sequencing and novel therapeutic products.

The synthesis of oligonucleotides involves a four-step cyclic process followed by multi-step downstream purification. This manufacturing process as well as environment, packaging, and container closure systems can be potential sources of contamination leading to inorganic impurities formation.

To control and monitor product safety, permitted daily exposure (PDE) limits of 24 elements are defined in ICH guideline Q3D(R2)1 and USP chapter <232>2 . ICH Q2(R1)3 and USP<233> 4 describe analytical measurement requirements and procedures for the measurement of those elemental impurities. Although oligonucleotide products have not been included in those regulatory guidelines yet, the industry common practice is to follow those guidelines.

In this study, an analytical workflow (Figure1) was developed in accordance with the ICH/USP guidelines for the analysis of elemental impurities in an oligonucleotide sample using an Agilent 7850 ICP-MS. Data was acquired to evaluate the accuracy, specificity, reproducibility, and ruggedness of the method.

Conclusions: The study has demonstrated the suitability of the Agilent 7850 ICP-MS for the identification and quantification of 24 elements in a synthetic oligonucleotide sample in compliance with existing USP and ICH guidelines. Instrument and method performance requirements for stability, detectability, precision, specificity, ruggedness, accuracy, and spike recovery were all achieved per the criteria given in USP <232>/<233> and ICH Q3D(R2)/Q2(R1).

As the development and use of oligonucleotides in therapeutic applications continue to advance, the elemental impurities analysis of oligonucleotides using 7850 ICP-MS can safeguard the product quality and safety.

3. Thermo Fisher Scientific: Accurate and reliable multielement analysis of alternative protein foods using ICP-MS

• Application note - Food safety

Goal: To demonstrate the applicability of the Thermo Scientific™ iCAP™ RQplus ICP-MS instrument for fast and accurate, highly sensitive, and reliable determination of nutritional and toxic trace elements in alternative protein food samples.

Keywords: ICP-MS, AGD, He-KED, half-mass correction, accuracy, robustness, toxic elements, nutritional elements

4. Thermo Fisher Scientific: Analysis of process water from hydrogen fuel cells using triple quadrupole inductively coupled plasma mass spectrometry (ICP-MS)

• Application note - Industrial

Goal: To demonstrate the analysis of process water from hydrogen fuel cells for inorganic trace contaminants with high sensitivity and accuracy using triple quadrupole ICP-MS.

Keywords: Fluorine, fuel cell, high resolution, ICP-MS, KED, PEM, process water, triple quadrupole, TQ-O₂ mode

5. Thermo Fisher Scientific: Combining full spectrum read-out and innovative automation capabilities for the robust and fast analysis of major and trace elements in fertilizers using ICP-OES

• Application note - Environmental

Goal: To demonstrate the capabilities of the Thermo Scientific™ iCAP™ PRO XP ICP-OES Duo instrument, in conjunction with the Thermo Scientific™ iSC-65 Autosampler, for the fast and robust elemental analysis of fertilizers.

Keywords: ICP-OES, robustness, method validation, sensitivity, Step Ahead, limits of quantitation, analytical testing, toxic elements.