<p><strong>Dear friends and fans of mass spectrometry,</strong></p>
<p><strong>The history of a method for studying of matter known as mass spectrometry dates back more than a century. The foundations have mostly been laid by physics studying discharges in gases. After about five decades mass spectrometry entered the domain of chemistry and evolved into an excellent tool for studying the structure of chemical compounds. Recently we are witnessing its expansion into the field of cellular, molecular, and structural biology. The technology of mass spectrometry developed immensely over the time. Let us take a tour into the history and learn about the past technologies. Let us explore the state-of-art mass spectrometry.</strong></p>
<p>A technical museum focused on unique and significant part of science, the Czech Museum of Mass Spectrometry will display and explain laboratory instrumentation that encompasses physics, chemistry, engineering and informatics and combines them into a device that contributes to many parts of our daily life.</p>
<p>Czech and English speaking visitors will have an opportunity to learn about the principles and applications of mass spectrometry, its history, and important scientists including Nobel price winners, while experiencing a remarkable collection of mass spectrometers. Founded by mass spectrometry enthusiasts Jaroslav Pol (Thermo Scientific) and Josef Cvacka (Institute of Organic Chemistry and Biochemistry) and sponsored by Frantisek Turecek (University of Washington, Seattle), the Czech Museum of Mass Spectrometry is now being assembled and will open in Prague in 2017. Donations of mass spectrometry artifacts are gratefully appreciated; those willing to contribute please contact the curators.</p>
<p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/d3e7627196634c0a8fa129f95fef6edd/obrazek.png" alt="The Czech Museum of Mass Spectrometry"/></p>
<h3><strong>Mass spectrometry</strong></h3>
<p>Study of matter through the formation of gas-phase ions that are characterized using mass spectrometers by their mass, charge, structure, and/or physico-chemical properties.</p>
<h3><strong>Mass Analyzers</strong></h3>
<h5><strong>Fourier Transform Ion Cyclotron Resonance</strong></h5>
<p>Mass spectrometer based on the principle of ion cyclotron resonance in which an ion in a magnetic field moves in a circular orbit at the cyclotron frequency that is characteristic of its m/z value. Ions are coherently excited to a larger radius orbit using a pulse of radio frequency electric field, and their image charge is detected on receiver plates as a time domain signal. Fourier transformation of the time domain signal results in a frequency domain signal that is converted to a mass spectrum based on the inverse relationship between cyclotron frequency and m/z.</p>
<p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/1628c6d87adf47538f70c2d7ce971db9/obrazek.png" alt="The Czech Museum of Mass Spectrometry/Martin Strohalm"/></p>
<h5><strong>Ion Trap</strong></h5>
<p>Device for spatially confining ions using electric and magnetic fields alone or in combination.</p>
<p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/bcc0887a778f4df29f488bcd87ce8718/obrazek.png" alt="The Czech Museum of Mass Spectrometry/Martin Strohalm"/></p>
<h5><strong>Linear Ion Trap</strong></h5>
<p>Two-dimensional Paul ion trap in which ions are confined in the axial dimension by means of a static electric potential.</p>
<p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/6d35a6cdb4ee4baa95ad2d831b20db19/obrazek.png" alt="The Czech Museum of Mass Spectrometry/Martin Strohalm"/></p>
<h5><strong>Orbitrap</strong></h5>
<p>Ion trapping device that consists of an outer barrel-like electrode and a coaxial inner spindle-like elec- trode that form an electrostatic </p>
<p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/4c8de0a71fef446fa44829e9d37c8b62/obrazek.png" alt="The Czech Museum of Mass Spectrometry/Martin Strohalm"/></p>
<h5><strong>Sector</strong></h5>
<p>Device that produces a magnetic field perpendicular to a charged particle beam that deflects the beam to an extent that is proportional to the ratio of particle momentum and charge.</p>
<p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/240ae6e09cb443508bf7dce8309b2928/obrazek.png" alt="The Czech Museum of Mass Spectrometry/Martin Strohalm"/></p>
<h5><strong>Time of Flight</strong></h5>
<p>Mass spectrometer that separates ions by m/z in a field-free region after acceleration through a fixed accelerating potential. Ions of the same initial translational energy and different m/z require different times to traverse a given distance in the field-free region.</p>
<p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/0d0eaa3a8aa544d1abcca833a9e6e9ae/obrazek.png" alt="The Czech Museum of Mass Spectrometry/Martin Strohalm"/></p>
<h5><strong>Triple Quadrupole</strong></h5>
<p>Tandem mass spectrometer comprising two transmission quadrupole mass spectrometers in series, with a (non-selecting) RF-only quadrupole (or other multipole) between them to act as a collision cell.</p>
<p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/b6e4bd36ccb44cd8a93e84353b28a357/obrazek.png" alt="The Czech Museum of Mass Spectrometry/Martin Strohalm"/></p>
<h3><strong>Ion Sources</strong></h3>
<h5><strong>Atmospheric pressure chemical ionization</strong></h5>
<p>Atmospheric pressure chemical ionization (APCI) is chemical ionization of a sample that is a gas or nebulized liquid, using an atmospheric pressure corona discharge or beta emitter such as 63Ni.</p>
<p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/d562c1ce1a9f43c78d8a93a2c6c43932/obrazek.png" alt="The Czech Museum of Mass Spectrometry/Martin Strohalm"/></p>
<h5><strong>Atmospheric pressure photoionization</strong></h5>
<p>Atmospheric pressure photoionization (APPI) is direct ionization of molecules at atmospheric pressure by electron detachment induced by photons forming M+•, or atmospheric pressure chemical ionization in which the reactant ions are generated by photoionization of suitable dopant species and subsequent ion/molecule reactions of their molecular ions.</p>
<p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/828a17ec377a4313bdd59f9275192e87/obrazek.png" alt="The Czech Museum of Mass Spectrometry/Martin Strohalm"/></p>
<h5><strong>Desorption electrospray ionization</strong></h5>
<p>Desorption electrospray ionization (DESI) is formation of gas-phase ions from a solid or liquid sample at atmospheric pressure through the inter- action of electrosprayed droplets with the sample surface.</p>
<p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/86624af57b96403586bd27b3bafccec3/obrazek.png" alt="The Czech Museum of Mass Spectrometry/Martin Strohalm"/></p>
<h5><strong>Electrospray ionization</strong></h5>
<p>Electrospray ionization (ESI) is spray ionization process in which either cations or anions in solution are transferred to the gas phase via formation and desolvation at atmospheric pressure of a stream of highly charged droplets that result from applying a potential difference between the tip of the electrospray needle containing the solution and a counter electrode.</p>
<p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/673ec39a73b64561805cf60670486635/obrazek.png" alt="The Czech Museum of Mass Spectrometry/Martin Strohalm"/></p>
<h5><strong>Fast atom bombardment ionization</strong></h5>
<p>Fast atom bombardment ionization (FAB) is ionization of molecules initiated by a beam of neutral atoms with translational energies in the keV range. Labile molecules susceptible to dissociation are dissolved in an involatile liquid matrix that absorbs the energy of the bombarding atoms to form a selvedge region above the liquid surface in which ionization of the molecules occurs.</p>
<p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/afda171085f54f6e856bc930cf873fca/obrazek.png" alt="The Czech Museum of Mass Spectrometry/Martin Strohalm"/></p>
<h5><strong>Matrix-assisted laser desorption/ionization</strong></h5>
<p>Matrix-assisted laser desorption/ionization (MALDI) is formation of gas-phase ions from molecules present in a solid or liquid matrix that is irradiated with a laser. The matrix is a material that absorbs the laser energy and promotes ionization.</p>
<p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/39f899169e27496f938621f0d25a0f12/obrazek.png" alt="The Czech Museum of Mass Spectrometry/Martin Strohalm"/></p>
<h5><strong>Secondary ion mass spectrometry</strong></h5>
<p>Secondary ion mass spectrometry (SIMS) is technique in which a focused beam of primary ions produces secondary ions by sputtering from a solid surface. The secondary ions are analyzed by mass spectrometry.</p>
<p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/fd584fd784ab4c5197b461de5c42c5ee/obrazek.png" alt="The Czech Museum of Mass Spectrometry/Martin Strohalm"/></p>


The Czech Museum of Mass Spectrometry

<h3><strong>HOW TO WEIGH A MOLECULE?</strong></h3>
<p>Imagine that you want <strong>to weigh a water molecule</strong>. You cannot just place it on a weighing pan because it certainly would not work. You need a much more sophisticated device called <strong>a mass spectrometer</strong>.</p>
<p><strong>The first such instrument was constructed by J. J. Thomson in 1912</strong>. Since then, mass spectrometry has developed into a fascinating field with many practical applications.</p>
<p><a href="https://lcms.labrulez.com/library?categoryItems=12&amp;instrumentationItems=31&amp;publicationTypeItems=1-7-2-5-4&amp;search=newborn+screening"><strong>Newborn screeningg</strong></a>, <a href="https://lcms.labrulez.com/library?categoryItems=3&amp;instrumentationItems=31&amp;publicationTypeItems=1-7-2-5-4&amp;search=doping"><strong>doping tests of athletes</strong></a>, <a href="https://lcms.labrulez.com/library?categoryItems=1&amp;instrumentationItems=31&amp;publicationTypeItems=1-7-2-5-4&amp;search=contaminants"><strong>analysis of pollutants</strong></a>, <a href="https://lcms.labrulez.com/library?categoryItems=5&amp;instrumentationItems=31&amp;publicationTypeItems=1-7-2-5-4&amp;search=drug"><strong>testing of new drugs</strong></a> or <strong>space exploration</strong> are only a few <strong>examples of the application of mass spectrometry</strong>. Yet there are many more.</p>
<p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Czech_Museum_of_MS_Mass_Spectrometer_d6267dd11d/Czech-Museum-of-MS-Mass-Spectrometer.jpg" alt="Czech Museum of MS: Mass Spectrometer"/></p>
<h3><strong>MASS SPECTROMETER</strong></h3>
<p><strong>A mass spectrometer</strong> is a remarkable instrument that <strong>provides information about the mass and structure of molecules</strong>. In essence, it is a very accurate scale for electrically charged molecules. However, such a scale does not resemble the traditional ones known from kitchens and pharmacies. It is an ingenious device that <strong>uses electric and magnetic fields to manipulate, separate and detect charged molecules</strong>. Some instruments also make it possible to break charged molecules into pieces, which is useful for deducing the molecular structure.</p>
<p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Czech_Museum_of_MS_A_gridless_two_stage_reflectron_from_the_MALDI_TOF_system_Biflex_II_manufactured_by_Bruker_Daltonics_690d1900fb/Czech-Museum-of-MS-A-gridless-two-stage-reflectron-from-the-MALDI-TOF-system-Biflex-II-manufactured-by-Bruker-Daltonics.jpg" alt="Czech Museum of MS: A gridless two-stage reflectron from the MALDI-TOF system Biflex II manufactured by Bruker Daltonics"/></p>
<h3><strong>OUR MISSION</strong></h3>
<p>The museum aims <strong>to collect</strong> and <strong>display artifacts in mass spectrometry</strong>, especially those <strong>associated with our geographical region</strong>. Students professionals and the general public can look a the key components of spectrometers and understand <strong>how mass spectrometers work</strong>. The technical solutions and stories behind the exhibits can inspire young scientists as wall as experienced designers of scientific instruments.</p>
<p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Czech_Museum_of_MS_Mass_Spectrometry_history_in_Czech_Republic_fce8ca9112/Czech-Museum-of-MS-Mass-Spectrometry-history-in-Czech-Republic.jpg" alt="Czech Museum of MS: Mass Spectrometry history in Czech Republic"/></p>
<h3><strong>EXHIBITION</strong></h3>
<p>The exhibition shows instrument components tha are often <strong>hidden in inaccessible vacuum chambers of mass spectrometers</strong>. You can take a closer look at them, understand their function, and at the same time admire their technical perfection and beauty. Use your smartphone to learn more about the exhibit you are currently viewing. <strong>The posters on the walls will teach you about mass spectrometry and its history</strong>.</p>
<p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Czech_Museum_of_MS_A_grid_cell_of_LTQ_FT_Ultra_Thermo_Electron_Corporation_7e8ae7d076/Czech-Museum-of-MS-A-grid-cell-of-LTQ-FT-Ultra-(Thermo-Electron-Corporation).jpg" alt="Czech Museum of MS: A grid cell of LTQ FT Ultra (Thermo Electron Corporation)"/></p>
<h3><strong>DONATE AN EXHIBIT</strong></h3>
<p>The museum accepts <strong>donations</strong> to its collection, especially <strong>instruments</strong> or <strong>parts of them</strong> (even broken, damaged or worn), <strong>documents</strong>, and <strong>photographs related to mass spectrometry and its history</strong>. All donations are highly appreciated.</p>
<p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Czech_Museum_of_MS_EI_source_from_the_single_quadrupole_mass_spectrometer_TRIO_1000_manufactured_by_VG_Masslab_Altrincham_UK_9824bf2fd9/Czech-Museum-of-MS-EI-source-from-the-single-quadrupole-mass-spectrometer-TRIO-1000-manufactured-by-VG-Masslab-(Altrincham-UK).jpg" alt="Czech Museum of MS: EI source from the single quadrupole mass spectrometer TRIO 1000 manufactured by VG Masslab (Altrincham, UK)"/></p>
<p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Czech_Museum_of_MS_A_triple_stage_quadrupole_LC_MS_mass_spectrometer_TSQ_Vantage_manufactured_by_Thermo_Scientific_fbf31e162f/Czech-Museum-of-MS-A-triple-stage-quadrupole-LC-MS-mass-spectrometer-TSQ-Vantage-manufactured-by-Thermo-Scientific.jpg" alt="Czech Museum of MS: A triple stage quadrupole LC-MS mass spectrometer TSQ Vantage manufactured by Thermo Scientific"/></p>
<h3><strong>FIND US HERE</strong></h3>
<h5><a href="https://www.uochb.cz/en"><strong>Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences</strong></a></h5>
<ul>
<li>Building A, 2nd floor</li>
<li>Flemingovo náměstí 542/2</li>
<li>160 00 Praha 6</li>
<li>Czech Republic</li>
</ul>
<h3><strong>HOURS AND ADMISSION</strong></h3>
<p>The museum is <strong>open daily from 8 am to 6 pm.</strong> A guide is required to move around the building.</p>
<p><strong>Please call in advance</strong> to check the guide‘s availability.</p>
<ul>
<li><strong>Inquiries:</strong> Josef Cvačka</li>
<li>+420 731 447 868</li>
<li>josef.cvacka@uochb.cas.cz</li>
</ul>
<p><strong>The admission is free for all visitors.</strong></p>
<p><strong>The Czech Academy of Sciences has contributed financially to the promotion of the museum.</strong></p>


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The Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences (IOCB Prague) is a leading scientific institution in the Czech Republic, recognized internationally. Its primary mission is basic research in the fields of chemical biology and medicinal chemistry, organic and material oriented chemistry, chemistry of natural compounds, biochemistry and molecular biology, physical chemistry, theoretical chemistry, and analytical chemistry. 

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