Our Library never stops expanding. What are the most recent contributions to LabRulezICPMS Library in the week of 6th April 2026? Check out new documents from the field of spectroscopy/spectrometry and related techniques!<blockquote>👉 <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/library">SEARCH THE LARGEST REPOSITORY OF DOCUMENTS ABOUT SPECTROSCOPY/SPECTROMETRY RELATED TECHNIQUES</a></blockquote><blockquote>👉 Need info about different analytical techniques? Peek into <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/library">LabRulezLCMS</a> or <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library">LabRulezGCMS</a> libraries.</blockquote>This week we bring you application notes by Metrohm, Shimadzu, Thermo Fisher Scientific and Waters Corporation!<h3>1. Metrohm: Whey permeate analysis with NIRS</h3>Monitor dairy production processes easily in seconds<ul><li>Application note</li><li><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/labrulez-bucket-strapi-h3hsga3/an_nir_144_download_34598659f1.pdf">Full PDF for download</a></li></ul>Whey permeate, a byproduct of manufacturing whey protein powder, contains high amounts of lactose, phosphate, and minerals. Because of its sweet and mild taste, whey permeate is often used in bakeries and chocolate manufacturing. The key to optimizing whey permeate production is to control production streams in real time. It is important to monitor the production process with highthroughput analytical techniques to maximize product yield and ensure high product quality.&nbsp;Nearinfrared spectroscopy (NIRS) is a fast, and chemicalfree analysis technique that can support this kind of testing. NIR spectroscopy can measure the most important quality parameters (i.e., protein, lactose, moisture, ash, pH, and phosphate) simultaneously in whey permeate without any sample preparation. The NIRS solution is fast, easy to operate, and can be used atline or offline in a quality control lab.<h4>EXPERIMENTAL EQUIPMENT&nbsp;</h4>158 whey permeate samples were analyzed on a <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/library?mainauthorItems=220&amp;search=NIR+analyzer">Metrohm NIR Analyzer</a> equipped with a small cup accessory. All measurements were performed in reflection mode (1000–2250 nm). Metrohm software was used for data acquisition and prediction model development.<h4>CONCLUSION&nbsp;</h4>This Application Note demonstrates the feasibility of using NIR spectroscopy for whey permeate quality control. Near infrared-spectroscopy is a rapid, nondestructive analytical technique that can monitor the production process of dairy products. Aside from the analysis of whey permeate, the whey protein production stream can also be monitored by NIRS.<h3>2. Shimadzu: Measurement of Residual Metal Catalysts by X-ray Fluorescence</h3><ul><li>Application note</li><li><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/labrulez-bucket-strapi-h3hsga3/an_01_01086_en_4beb25fd1d.pdf">Full PDF for download</a></li></ul><h4>User Benefits</h4><ul><li><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/library?mainauthorItems=1&amp;search=ALTRACE">ALTRACE</a> can determine levels of heavy metals present in organic compounds at around 1 mg/kg in under 10 minutes per sample.</li><li>Analyzing and managing levels of residual metal catalysts can be performed by simply placing samples in the sample vessel and analyzing them without the need for complex sample pretreatment.</li><li>By increasing the X-ray tube power and optimizing the optical design, the sensitivity of ALTRACE for heavy metals has been dramatically improved compared to the previous model.</li></ul>Many industrial products we encounter every day are produced from organic compounds by manufacturing processes that utilize a range ofsynthesisreactions and metal catalysts. Catalysis can be classified as either homogeneous or heterogeneous (although drug and chemical production processes typically use homogeneous catalytic systems). While homogeneous catalysis allows for precise control over catalytic reactions, recovering the catalyst after the reaction can be difficult.&nbsp;Nevertheless, managing the levels of residual catalysts in industrial products is critical to ensure safety and because of their high costs. For example, the ICH Q3D Guideline for Elemental Impurities (adopted in April 2017) requires risk assessments when materials such as metal catalysts are added intentionally during a production process.&nbsp;Energy dispersive X-ray fluorescence (EDXRF) spectrometry offers a simple but effective technique for assessing the levels of residual metal catalysts. Normally, the lower limit of quantification for EDXRF spectrometric analysis of heavy metals is above 1 mg/kg, which limitsits use in quantitative analysis. However, the <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/library?mainauthorItems=1&amp;search=ALTRACE">ALTRACE</a> is equipped with a high-power X-ray tube that dramatically improves its sensitivity for heavy metals, enabling their determination at 1 mg/kg and below in lessthan 10 minutes. This Application News describes using ALTRACE to determine residual levels of a homogeneous catalyst after a synthesis reaction. The catalyst used in this analysis is palladium (Pd), which is a widely applied heavy metal catalyst, and the reaction catalyzed by the Pd catalyst is a cross-coupling reaction. A metal scavenger and activated carbon were each used to remove the Pd catalyst from the reaction products. Metal scavengers are frequently used in this role, and activated carbon offers a relatively cheap method for removing catalysts.<h4>Conclusion&nbsp;</h4>Common methods of elemental impurity analysis, such as atomic absorption spectrometry (AAS), ICP atomic emission spectroscopy (ICP-AES), and ICP mass spectrometry (ICP-MS), require liquid samples, so solid and powder samples must be prepared into a solution prior to analysis. However, EDXRF spectrometry can determine levels of elemental impurities regardless of the sample phase or form (solution, powder, etc.), provided the target element is distributed uniformly throughout the sample. The sensitivity of ALTRACE for heavy metals has been substantially improved compared to previous models, allowing for rapid quantitative determination of heavy metals at 1 mg/kg and below. Based on the performance presented in this article, ALTRACE is an effective tool for managing residual levels of metal catalysts.<h3>3. Thermo Fisher Scientific: The Raman Spectroscopy of Graphene and the Determination of Layer Thickness</h3><ul><li>Application note</li><li><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/labrulez-bucket-strapi-h3hsga3/raman_spectroscopy_graphene_determination_layer_thickness_an52252_29274e8aea.pdf">Full PDF for download</a></li></ul>Currently, a tremendous amount of study is being directed toward graphene. This interest is driven by the novel properties that graphene possesses and its potential use in a variety of application areas that include but are not limited to electronics, heat transfer, bio-sensing, membrane technology, battery technology and advanced composites. Graphene exists as a transparent two-dimensional network of carbon atoms. It can exist as a single atomic-layer thick material, or it can be readily stacked to form stable, moderately thick samples containing millions of layers—a form generally referred to as graphite. However, the interesting properties exhibited by graphene (substantial electrical and thermal conductivity, high mechanical strength, and high optical transparency) are only observed for graphene films that contain only one or a few layers. Therefore, developing technologies and devices based upon graphene’s unusual properties requires accurate determination of the layer thickness for materials under investigation. Raman spectroscopy can be employed to provide a fast, non-destructive means of determining layer thickness for graphene thin films.<h4>Instrument considerations&nbsp;</h4>There are a few specifications that should be considered when selecting a Raman instrument for graphene characterization. First, since graphene samples are usually very small, selecting a Raman instrument with microscopy capabilities is imperative.The next issue to consider is which excitation laser to select. While graphene measurements can be made successfully with any of the readily available Raman lasers, it is also important to consider the substrate that the graphene will be deposited onto. It is common for graphene to be deposited on on either Si or SiO2 substrates, and both of these materials can exhibit fluorescence with near-infrared (NIR) lasers such as 780 nm or 785 nm. For this reason, visible lasers are usually recommended, typically a 633 nm or 532 nm laser.&nbsp;Next, since relatively small wavenumber shifts can significantly impact the interpretation of the Raman spectra, it is crucial to have a robust wavelength calibration across the entire spectrum. Using a single point wavelength calibration with some other applications may be sufficient, but this only ensures that one wavelength is calibrated and leaves room for a large margin of error. A multipoint wavelength calibration that is regularly refreshed, such as the standard calibration routine used with <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/products?category=184&amp;manufacturerItems=3&amp;search=dxr3">Thermo Scientific DXR3 Raman instruments</a>, will provide considerably more confidence in the results. It is also necessary to have an instrument with high wavenumber precision to observe small wavenumber shifts when altering the sample. In fact, small wavenumber shifts can represent changes in the sample rather than represent the variability from the instrument. There is a common myth that it is necessary to utilize high resolution in order to achieve high wavenumber precision. Not only is this incorrect, but a high resolution will actually add considerable noise to the spectrum, which will add to the wavenumber variability. A high degree of wavenumber precision, such as that provided by the <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/products/2239">Thermo Scientific™ DXR™3 Raman Microscope</a>, will significantly improve data confidence even when you are evaluating band shifts from low levels of strain or doping. It is also important to have exact control of your laser power at the sample and be able to adjust that laser power in small increments. This is important to control temperature-related effects and to provide flexibility to maximize Raman signal while still avoiding sample heating or damage from the laser. The DXR3 Raman systems are equipped with a unique device called a laser power regulator, which maintains laser power with unprecedented accuracy and provides exceptional ability to fine-tune laser power and optimize it for each experiment.1&nbsp;Lastly, the Raman microscope must have an automated stage and associated software to generate detailed Raman point maps. As will be seen in the next section, Raman point mapping or imaging extends the single point measurement to assess a sample’s layer thickness uniformity. The Thermo Scientific OMNIC™ Software suite contains powerful mapping and processing tools that diminish the complexity of collecting highly detailed maps and interpreting their results.<h4>Conclusions&nbsp;</h4>Raman spectroscopy is an excellent tool for the characterization of graphene and layer thickness. Few techniques will provide as much information about the structure of graphene samples as Raman spectroscopy, and any lab doing graphene characterization without Raman would be at a significant disadvantage. The DXR3 Raman Microscope is an ideal Raman instrument for graphene characterization because it can provide the high level of stability, control, and sensitivity needed to produce confident results.<h3>4. Waters Corporation: See What’s Really in Your Formulation with Backgrounded Membrane Imaging</h3><ul><li>Application note</li><li><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/labrulez-bucket-strapi-h3hsga3/720009098_en_5d36d71789.pdf">Full PDF for download</a></li></ul>Protein aggregation in therapeutic protein products can induce adverse immunogenic responses in patients1–4 . Per the FDA’s recommendations, “strategies to minimize aggregate formation should be developed as early as feasible in product development”5 and “an assessment should be made of the range and levels of subvisible particles (2–10 µm) present in therapeutic protein products initially and over the course of the shelf life”.5 Yet, accurate subvisible protein aggregation analysis has remained elusive to protein drug formulators since current subvisible analyzers are not sensitive enough to measure protein aggregates effectively. In this application note, we explore how backgrounded membrane imaging (BMI), a high refractive index contrast technique used by the HORIZON particle analysis system, performs highly sensitive measurements of subvisible protein aggregates in the 2 µm–4 mm size range, enabling 30% higher reproducibility compared to flow imaging.<h4>Conclusion&nbsp;</h4>When studying the impact of protein aggregate refractive index, IgG protein aggregates analyzed on both the <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/library?mainauthorItems=5&amp;search=HORIZON">HORIZON® instrument</a> and flow imager systems produced equivalent particle count trends. However, the HORIZON® system was more sensitive (measured more overall counts) and had overall lower variability with average CVs of 14.4% compared to the flow imager which produced average CVs of 20.1%. The differences in variability and counts were most pronounced at lower concentrations and size range respectively. Given that most particles in a therapeutic drug formulation are small, the inability of flow imagers to accurately count the smallest of protein aggregates has a dramatic impact on the total number of particles measured. This can mean an undercounting by as much as 3–10X depending on the protein and formulation conditions.&nbsp;High variability at low concentrations in flow imagers can pose a hurdle for early stage analysis were sample is scarce. In low volume analysis (&lt;250 µL), the possibility of measuring fewer particles increases, therefore it is imperative to have high sensitivity measurements when already challenged by low sampling statistics.&nbsp;In the excipient effect study, sucrose did not have an impact on the overall particle counts when measured using the HORIZON® system. This contrasts with previous studies comparing excipient effects on three flow imagers.10 In each case, the particle counts decreased up to 30% or more using standard sucrose formulation concentrations of 0–20%. The difference between the data generated by BMI and FI can be attributed to the fact that the HORIZON® instrument is not affected by particle or solution refractive index.&nbsp;Flow imagers are deeply vulnerable to the impact of refractive index when measuring protein aggregates due to their translucency and the negative impact of surfactants. Due to this basic optical phenomenon, flow imagers can dramatically undersize and undercount particles. Finding the right tool for the job will have a critical impact on data accuracy and sensitivity. Powered with BMI, the HORIZON® system provides high refractive index contrast analysis to enable accurate, robust, and sensitive subvisible particle counting from 2 µm–4 mm in as little as 25 µL of sample and 96 samples in under 2 hours.

News from LabRulezICPMS Library - Week 15, 2026

The set of soils consist of two natural agricultural soils differing in elemental composition&nbsp;<ul><li>AN-ZP01: Heavy loam with normal analyte levels&nbsp;</li><li>AN-ZP02: Silty clay loam contaminated with some heavy metals&nbsp;</li></ul>Contents of element extractable fractions with aqua regia according to ISO 11466&nbsp;<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/ANALYTIKA_agricultural_soil_CRM_0534e68e65.jpg" alt="ANALYTIKA: Matrix CRM of agricultural soil METRANAL® CRM AN-ZP01 and AN-ZP02" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_ANALYTIKA_agricultural_soil_CRM_0534e68e65.jpg 156w," sizes="100vw" width="827" height="827"><h5>Packing:&nbsp;</h5><ul><li>50 g of powder of the respective soil with a particle size of less than 100 µm in amber glass bottle.&nbsp;</li></ul><h5>Intended use:&nbsp;</h5>This set of certified reference materials is intended primarily for use in realizing metrological traceability, validation of analytical methods and the transfer of property values to other materials of similar composition.&nbsp;<h5>Recommended analytical methods for method dependent measurements:</h5><ul><li>Flame AAS, ETA-AAS, ICP-OES, ICP-MS, AMA-254&nbsp;</li></ul><h5>Metrological traceability:&nbsp;</h5>Metrological traceability is realized by using certified calibration standards solutions for the calibration of measurement methods used (direct traceability to SI unit) and/or by simultaneous analysis of a matrix CRM (RM) of similar composition.<h5>Sample preparation (aqua regia extract according to ISO 11466):&nbsp;</h5>Weigh a 3 g (± 0.001 g) sample into a 100 ml round bottom flask. Add a small amount of water (2 to 3 ml) to obtain a slurry, then 7.5 ml of conc. HNO3 (density 1.40 g/ml). Let the mixture stand until intensive foaming ceases, then add (in several portions) 22.5 ml of conc. HCl (density 1.19 g/ml), shake the mixture manually, cover the flask with a watch glass, and let stand for 16 hours (overnight) at the laboratory temperature (20 ± 2°C). Then mount a reflux condenser (a Dimroth type or similar) of about 40 cm length on the top of the flask and boil gently under reflux for 2 hours. After cooling, rinse the condenser with 20 ml of warm (~ 50°C) dilute nitric acid (5%, v/v), the liquid being collected in the round bottom flask. Remove the condenser and filter the solution from the flask through an acid-resistant high density paper filter and collect it in a 100 ml volumetric flask (make sure in preliminary tests that a suitable filter was chosen, so that the filtrate is clear). Rinse the filter and the residue three times with 5 ml of warm (~ 50°C) dilute nitric acid (5%, v/v); allow to cool and dilute with nitric acid 5% (v/v) to the mark. Transfer immediately the solution from the volumetric flask into a clean, dry 100 ml polyethylene bottle. Realize three blanks using exactly the same analytical procedure.&nbsp;It is acceptable to realize the operation described above in a glass beaker covered with a watch glass. Minimum sample size for analysis is defined with the prescribed working procedure.&nbsp;<h5>Storing and instruction for use:&nbsp;</h5>These CRM have to be stored in original bottle and between 5-30°C (in a dark and dry place). The materials should be analysed in the "as received" state and their dry weight should be determined on non-analysed aliquots oven-dried at 105°C till the constant weight. The material in the bottle must be rehomogenized before each use by mechanical shaking of the content for 1-2 minutes. The bottle should be opened a minimum of 2 minutes after rehomogenization in order to prevent an escape of fine powder particles from the bottle into the environment and their sedimentation.&nbsp;<h5>Certified and indicative values and their uncertainties:&nbsp;</h5>The certified and indicative values of extractable element fraction are summarized in Table 1. The overall means evaluated have been given a status of certified and indicative values using the following criteria: data should be available from at least two independent analytical methods, at least 5 and 3 accepted laboratory means should be available for calculation of the overall mean for certified and indicative value, respectively. At combined uncertainties presented, the contribution of uncertainty of characterization of a particular property value is dominant.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/ANALYTIKA_Table_1_Certified_and_indicative_values_of_contents_of_element_fractions_extractable_by_f56fa06aa5.jpg" alt="ANALYTIKA: Table 1 - Certified and indicative values of contents of element fractions extractable by aqua regia in CRM AN-ZP01 and AN-ZP02 and their associated uncertainties." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_ANALYTIKA_Table_1_Certified_and_indicative_values_of_contents_of_element_fractions_extractable_by_f56fa06aa5.jpg 187w," sizes="100vw" width="998" height="835"><h5>Chemical composition of soil matrix:&nbsp;</h5>The bulk composition of CRM AN-ZP01 and AN-ZP02 is shown in Table 2. The values presented in this table are not certified, but they may be useful for considerations concerning possible interferences while determining analytes given in Table 1, and for selection of suitable decomposition procedures if destructive analytical methods are to be used.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/ANALYTIKA_Table_2_Matrix_composition_of_CRM_AN_ZP_01_and_AN_ZP_02_of_the_oxides_dry_cd1273cf9c.jpg" alt="ANALYTIKA: Table 2 Matrix composition of CRM AN-ZP01 and AN-ZP02 (% of the oxides dry weight at 105°C)" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_ANALYTIKA_Table_2_Matrix_composition_of_CRM_AN_ZP_01_and_AN_ZP_02_of_the_oxides_dry_cd1273cf9c.jpg 170w," sizes="100vw" width="883" height="811"><h5>Note:&nbsp;</h5>Detailed information about the production, homogeneity testing and characterization of these CRM are described in the Certification report, which is available on request.

Matrix CRM of agricultural soil METRANAL® CRM AN-ZP01 and AN-ZP02

<div><div><div>Our immune system is incredibly powerful: among other things, it can recognize and destroy cancer cells. But tumors can be just as effective at avoiding detection – they build “invisibility shields” to protect themselves from attack.</div></div><div>One breakthrough in cancer therapy has been immune checkpoint inhibitors (ICIs), drugs that reactivate immune T cells and help them fight tumors again. However, only about 20–50% of patients respond well to this treatment. Researchers are therefore seeking alternative therapeutic strategies. A small and well-known molecule called adenosine plays a key role in these efforts.When tumor cells are stressed or dying, they release ATP, which is normally a signal that something is wrong in the tissue. But in the tumor microenvironment, ATP gets rapidly broken down by two enzymes, CD39 and CD73. Released adenosine acts like a chemical “calm-down” signal, binds to immune cells (T cells, NK cells, and others), and tells them to slow down, reducing their ability to kill cancer cells. Targeting CD73 therefore represents a promising strategy for developing new cancer treatments.</div><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/UOCHB_Nove_latky_mohou_podporit_imunitni_system_v_boji_s_rakovinou_88c5e82cd5.jpeg" alt="IOCB Prague: Development of potent inhibitors to boost the immune system's ability to fight cancer" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_UOCHB_Nove_latky_mohou_podporit_imunitni_system_v_boji_s_rakovinou_88c5e82cd5.jpeg 245w," sizes="100vw" width="661" height="363">At IOCB Prague, interdisciplinary teams led by Jan Řezáč, Jan Konvalinka, and Michal Hocek used a newly developed high-throughput screening method to test over 5,000 compounds, identifying two ribonucleoside derivatives as promising CD73 inhibitors.The scientists then improved the compounds’ activity by carefully modifying the ribonucleoside scaffold with bulky (het)aryl groups. Further optimization improved the pharmacokinetic properties of these compounds, yielding inhibitors with low clearance, long half-life, high solubility, and strong selectivity over related enzymes such as CD39.In cellular experiments, the compounds reduced adenosine production in cancer cells, restored T cell activation, and showed no toxicity toward human fibroblasts. The most active compound showed a single-digit picomolar inhibition constant (Ki).These findings establish a strong foundation for further in vivo efficacy and combination studies, which will explore the therapeutic potential of this novel inhibitor class.<blockquote><h4>The Original article</h4><h4><a target="_blank" rel="noopener noreferrer" href="https://pubs.acs.org/doi/10.1021/acsptsci.5c00707">Potent Competitive Inhibitors of Ecto-5′-nucleotidase (CD73) based on 6-(Het)aryl-7-deazapurine Ribonucleoside 5′-O-Bisphosphonates</a></h4>Ugnė Šinkevičiu̅tė, Magdalena Šímová, Radek Staník, Lenka Poštová Slavětínská, Kristýna Blažková, Pavel Šácha, Martin Lepšík, Jan Řezáč, Jan Konvalinka, Tereza Ormsby, Michal Tichý, Michal HocekACS Pharmacol. Transl. Sci. 2026, 9, 1, 191–213<a target="_blank" rel="noopener noreferrer" href="https://pubs.acs.org/doi/10.1021/acsptsci.5c00707">https://pubs.acs.org/doi/10.1021/acsptsci.5c00707</a><h6>licensed under <a target="_blank" rel="noopener noreferrer" href="https://creativecommons.org/licenses/by/4.0/">CC-BY 4.0</a></h6></blockquote><h4>Abstract</h4>CD73 generates immunosuppressive adenosine in the tumor microenvironment and is a promising target for cancer immunotherapy. We have designed and systematically studied diverse 2-substituted 7-deazapurine ribonucleoside 5′-O-bisphosphonates bearing a variety of (het)aryl groups at position 6 and discovered their highly potent and selective CD73 inhibition activity. The most active compounds (with single-digit picomolar Ki) contained bicyclic (het)aryl groups at position 6 in combination with chlorine at position 2. Further optimization of pharmacokinetic properties identified inhibitors with low clearance, long half-life, high solubility, and excellent selectivity over CD39 and NTPDase3. They effectively suppressed adenosine formation in MDA-MB-231 cells, rescued CD8+ T cell activation, and were nontoxic to human fibroblasts. Overall, their profile compares favorably with AB680, a CD73 inhibitor currently in phase I/II clinical trials.</div>

Development of potent inhibitors to boost the immune system's ability to fight cancer

Article

Product

Application

Scientific article

Science and research

The Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences (IOCB Prague) is a leading scientific institution in the Czech Republic, recognized internationally. Its primary mission is basic research in the fields of chemical biology and medicinal chemistry, organic and material oriented chemistry, chemistry of natural compounds, biochemistry and molecular biology, physical chemistry, theoretical chemistry, and analytical chemistry. 

Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences

Everything from the world of analytical chemistry in one place. We connect people in solving their problems. At Labrulez you will find all the necessary information easily, quickly and clearly. Stop searching and start finding.

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Analytika is a Czech company that offers and produces certified reference materials (CRM) and (ultra)pure chemicals for quality control and quality assurance in laboratories, including accredited laboratories.

Our portfolio also includes pipettes and tips, digestors, PFA labware and other equipment for analytical laboratory and trace analysis.

ANALYTIKA

Agilent Technologies

Webinar will cover most if not all of the sample introduction choices using your ICP-OES.
This will include which sample introduction system is best for a variety of different sample matrices and how to optimize each. There are many different options and we will cover a lot of ground. Choosing the correct sample introduction and optimizing it correctly can lead to a large improvement in data quality and save you trouble with difficult matrices.
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Presenter: Paul Krampitz (Application Scientist, Agilent Technologies, Inc.)
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Graduate of Bowling Green State University with a Chemistry Bachelor of Science degree. Twenty – five years of Spectroscopy experience mainly Inductively Coupled Plasma (ICP) Spectroscopy as well as ICP-MS and AAS. Experience also includes X-Ray Fluorescence (ED, WD), Laser Ablation, Inorganic Speciation and Microwave Plasma Spectroscopy. Market Segment expertise includes environmental, petrochemical, metallurgical applications.
</blockquote>

Agilent Technologies: How to Optimize Your ICP-OES Sample Introduction System for Your Samples Type

How to Optimize Your ICP-OES Sample Introduction System for Your Samples Type

Sample introduction choices using your ICP-OES.

How to Optimize Your ICP-OES Sample Introduction System

Environmental matrices often present challenging interferences that may either be plasma or sample based.
Reduction of these interferences using kinetic energy discrimination and/or collisional dissociation have been proven to be effective using single quad ICP-MS using helium as the cell gas, however, reactive gasses can be very effective in either shifting the interference away from the analyte of interest, or shifting the analyte to a new mass, away from the associated polyatomic interference.
Using a reactive gas on a single quad ICP-MS risks creating undesired polyatomic interferences in the collision/reaction cell on other target analyte masses. By utilizing a quadrupole with single amu resolution before the collision/reaction cell, only the target analyte and associated interferences of the same mass enter the cell, giving the analyst ultimate control of the reaction products for a given analyte and associated interference. The optimization of reaction cell technology, combined with single unit mass resolution allows for more precise measurement of analytes in complex matrices, while also enjoying lower detection limits with tighter precision and improved accuracy. As regulatory detection limits become increasingly lower for environmental matrices, triple quadrupole ICP-MS/MS systems with single unit mass resolution technology has proven to be a superior approach for complex sample matrices.
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Presenter: Craig Jones (CP-MS Application Scientist, Agilent Technologies, Inc.)
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Craig has been with Agilent for over 15 years as an ICP-MS applications scientist. He has been involved with multiple type of applications for ICP-MS, including environmental, pharmaceutical, nutraceutical, semiconductor, geologic, and clinical analyses, to name a few. Previous to Agilent he worked in an environmental lab performing analysis and supervising both the inorganic and organic sections of the laboratory. In his spare time, Craig enjoys volunteering at the local marine science center, mountain biking, hiking and relaxing at the beach. Craig obtained a bachelor of science degree in chemistry from Fort Lewis College in Durango, CO.
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Agilent Technologies: Interference removal/mitigation utilizing ICP-MS/MS and single unit mass resolution technology

Interference removal/mitigation utilizing ICP-MS/MS and single unit mass resolution technology

Using a reactive gas on a single quad ICP-MS risks creating undesired polyatomic interferences in the collision/reaction cell on other target analyte masses.

Interference removal/mitigation utilizing ICP-MS/MS

Microwave Plasma Atomic Emission Spectrometer (MP-AES) is a suitable instrument for the multi-elemental analysis of a wide range of sample types, including complex organic matrices, and with the lowest cost of ownership.
Faster, easy to use and with better performance than Atomic Absorption Spectroscopy (AA), this technique is used in various industries. In this seminar we will discuss the basics, tips and tricks and applications for the MP-AES.
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Presenter: Sima Singha, PhD (ICP-OES Application Scientist, Atomic Spectroscopy, Agilent Technologies, Inc.)
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Sima has over fifteen years of hands on experience as an applications scientist in the field of atomic spectroscopy. Before joining Agilent in 2017, managed an agricultural chemistry laboratory for the analysis of water, soil, and plant tissue digests using ICP-OES for various EPA methods. She received a Ph.D. degree in Chemistry from the University of Illinois at Chicago with numerous peer-reviewed publications.
</blockquote>

Agilent Technologies: Fundamentals of Atomic Spectroscopy: MP-AES

Fundamentals of Atomic Spectroscopy: MP-AES

The basics, tips and tricks and applications for the MP-AES.

Knowing the right peristaltic pump tubing for your analysis can help you avoid QC failures, performance issues and sample re-runs.
Driven by insights from customers from around the world, Agilent has developed a range of Easy-fit peri pump tubing and have the maintenance advice to bring the confidence of knowing you will get the answers you need from your atomic spectrometer (ICP-MS, ICP-OES, MP-AES). Join us to learn how to make your sample delivery easier.
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**Presenter:**Gareth Pearson, Ph.D. (Product Manager ICP-MS Supplies, Agilent Technologies, Inc.)
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Dr. Pearson is Agilent&#39;s ICP-MS Supplies Product Manager based at the Spectroscopy Technology Innovation Centre in Melbourne, Australia. He has over 20 years experience in Analytical Chemistry and Spectroscopy.
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Gareth graduated from the University of Hull, in the UK, completing a Ph.D. titled &quot;Elemental Speciation and Miniaturised Sample Introduction Studies for ICP-MS&quot;. He has worked as a Product Manager in the UK and Australia for Spectroscopy and Sample Preparation instrumentation since 2007.
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Presenter: Lindsey Whitecotton (ICP-OES Supplies Product Manager, Agilent Technologies, Inc.)
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Lindsey Whitecotton received her Bachelor of Science degree in Biochemistry at Texas A&amp;M University Corpus Christi and her Master’s degree in Analytical Chemistry from Lehigh University. Prior to Agilent, Lindsey worked as an analytical chemist at Knolls Atomic Power Laboratory specializing in isotopic and ultra-trace elemental analysis. She joined Agilent in 2014 as an ICP-MS and ICP-OES Applications Chemist and is now the ICP-OES Supplies Product Manager. She has 11 years of experience in atomic spectroscopy and is based in the United States at Agilent’s Wilmington, Delaware facility.
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Agilent Technologies: How to pump the sample to the spectrometer for the best results

How to pump the sample to the spectrometer for the best results

Learn how to make your sample delivery easier.

How to pump the sample to the spectrometer

Knowing the right information at the right time can help you cut through the everyday complexities of your ICP-OES analysis.
Driven by insights from customers from around the world, Agilent has developed a range of innovative supplies, complete workflows, torch and nebulizer finder tool, and ICP-OES resource hub to bring the confidence of knowing you will get the answers you need to efficiently run your lab. Join us to learn how to make your ICP-OES applications easier to run, maintain and control.
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Presenter: Lindsey Whitecotton (ICP-OES Supplies Product Manager, Agilent Technologies, Inc.)
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Lindsey Whitecotton received her Bachelor of Science degree in Biochemistry at Texas A&amp;M University Corpus Christi and her Master’s degree in Analytical Chemistry from Lehigh University. Prior to Agilent, Lindsey worked as an analytical chemist at Knolls Atomic Power Laboratory specializing in isotopic and ultra-trace elemental analysis. She joined Agilent in 2014 as an ICP-MS and ICP-OES Applications Chemist and is now the ICP-OES Supplies Product Manager. She has 11 years of experience in atomic spectroscopy and is based in the United States at Agilent’s Wilmington, Delaware facility.
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Agilent Technologies: Part 2: How timely information and supplies can make you an ICP-OES Expert

How timely information and supplies can make you an ICP-OES Expert

How to make your ICP-OES applications easier to run, maintain and control.

ICP-OES Expert: Timely information and supplies

Knowing the right information at the right time can help you cut through the everyday complexities of your ICP-MS analysis.
Driven by insights from customers from around the world, Agilent has developed a range of Easy-fit supplies, complete workflows, nebulizer and cones finder tool, and ICP-MS resource hub to bring the confidence of knowing you will get the answers you need to efficiently run your lab. Join us to learn how to make your ICP-MS applications easier to run, maintain and control.
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Presenter: Gareth Pearson, Ph.D. (Product Manager ICP-MS Supplies, Agilent Technologies, Inc.)
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Dr. Pearson is Agilent&#39;s ICP-MS Supplies Product Manager based at the Spectroscopy Technology Innovation Centre in Melbourne, Australia. He has over 20 years experience in Analytical Chemistry and Spectroscopy.
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Gareth graduated from the University of Hull, in the UK, completing a Ph.D. titled &quot;Elemental Speciation and Miniaturised Sample Introduction Studies for ICP-MS&quot;. He has worked as a Product Manager in the UK and Australia for Spectroscopy and Sample Preparation instrumentation since 2007.
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Agilent Technologies: Part 1: How timely information and supplies can make you an ICP-MS Expert

How timely information and supplies can make you an ICP-MS Expert

How to make your ICP-MS applications easier to run, maintain and control.

ICP/MS Expert: Timely information and supplies

This series will go through the Fundamentals of Atomic Spectroscopy, with a focus on Flame and Graphite Furnace AA.
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Presenter: Greg Gilleland (Application Scientist, Agilent Technologies, Inc.)
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Greg began his spectroscopy career in 1987 in Colorado, working at a series of environmental labs. After 14 years working in the world of commercial environmental labs, he moved on to a spectroscopy instrument manufacturer where he performed service and sales functions over the course of 11 years. He has been with Agilent Technologies, Inc., since 2012 in the role of Application Scientist for ICP-OES, MP-AES and AA products.
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Agilent Technologies: Fundamentals of Atomic Spectroscopy: AA

Fundamentals of Atomic Spectroscopy: AA

Fundamentals of Atomic Spectroscopy, with a focus on Flame and Graphite Furnace AA.

Agilent offers a comprehensive inorganic standard portfolio which includes single and multi-elements certified reference materials.
We have enhanced our website to improve the searchability of instrument and application based elemental analysis standards. Agilent now also offers custom standards for your method specific needs.
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Presenter: Fred Chan (Chemical Standards Product Manager - CSD, Agilent Technologies, Inc.)
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Frederick Chan is a Chemical Standards Product Manager for Agilent’s Consumables and Supplies Division. He has a chemical engineering degree from University of California, Los Angeles and a MBA from University of Denver. Currently resides in Denver, CO and has been with Agilent for 14 years – in both the consumables and services divisions.
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Presenter: Mitesh Patel (Chemical Standards Product Manager - CSD, Agilent Technologies, Inc.)
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Mitesh Patel is a Product Manager for Chemical Standards for Consumable and Supplies Division (CSD) at Agilent. Mitesh has 13 years of experience in Chemistry and Material Science field. He has Ph.D. in Chemistry from University of Illinois, Chicago and MBA in Global Management from University of Wisconsin, Milwaukee.
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Agilent Technologies: Agilent Inorganic Standard Portfolio and Website Tools: Part 2 - ICP-OES/MP-AES/AA

Agilent Inorganic Standard Portfolio and Website Tools: Part 2 - ICP-OES/MP-AES/AA

Comprehensive inorganic standard portfolio which includes single and multi-elements certified reference materials.

Agilent Inorganic Standard Portfolio ICP-OES/MP-AES/AA

Agilent Technologies: Agilent Inorganic Standard Portfolio and Website Tools: Part 1 - ICP-MS

Agilent Inorganic Standard Portfolio and Website Tools: Part 1 - ICP-MS

Agilent Inorganic Standard Portfolio and Website - ICP-MS

Learn how to automate method building using smart features of the ICP-OES.
Run a quick scan of the sample using IntelliQuant and obtain sample insight and possible interferences without any calibration. Review your data like a pro with the new outlier flagging system and improve accuracy by selecting proper background and interference correction techniques.
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Presenter: Greg Gilleland (Application Scientist, Agilent Technologies, Inc.)
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Greg began his spectroscopy career in 1987 in Colorado, working at a series of environmental labs. After 14 years working in the world of commercial environmental labs, he moved on to a spectroscopy instrument manufacturer where he performed service and sales functions over the course of 11 years. He has been with Agilent Technologies, Inc., since 2012 in the role of Application Scientist for ICP-OES, MP-AES and AA products.
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Automate Method Development using a Smart ICP-OES