Electron spectroscopy for chemical analysis of liquids

<p><strong>In the week from June 29, the following webinars await you in the field of atomic and molecular spectroscopy and spectrometry</strong></p><blockquote><h4><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/webinars"><strong>👉 DETAILS AND REGISTRATION IN THE WEBINARS SECTION</strong></a></h4><p><strong>👉 Search and filter in the largest global database</strong> with over <strong>5 500 GC, LC, MS and spectroscopy webinars</strong>.</p></blockquote><h5><strong>1. Metrohm: Simplifying Through-Container Testing with Raman Spectroscopy in the Pharmaceutical Industry</strong></h5><ul><li>Mo, 29.6.2026 15:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/webinar/6308">Registration</a></li></ul><p>In this webinar, we will demonstrate a more robust and practical alternative to SORS for see-through Raman analysis.</p><h5><strong>2. SelectScience: End-to-end PAT: Connecting advanced analytics and data across the bioprocess lifecycle</strong></h5><ul><li>Mo, 29.6.2026 16:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/webinar/6307">Registration</a></li></ul><p>Learn how integrated PAT strategies combining NMR, Raman, IR, and digital workflows enable continuous process understanding, smoother tech transfer, and QbD from development to GMP manufacturing.</p><h5><strong>3. Bruker: Bruker Fluorescence Microscopy Solutions: Automated Imaging and Light-Sheet Microscopy</strong></h5><ul><li>Tu, 30.6.2026 17:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/webinar/6309">Registration</a></li></ul><p>Discover Bruker’s integrated imaging ecosystem combining light-sheet microscopy, high-content screening, and high-performance data management for scalable, high-quality biological imaging workflows.</p><h5><strong>4. Agilent Technologies: Measuring Diverse Samples with UV/VIS Spectrometers and Integrating Spheres</strong></h5><ul><li>Tu, 30.6.2026 20:30 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/webinar/6052">Registration</a></li></ul><p>This webinar will discuss diffuse transmission and reflection UV/VIS measurements, including how to perform measurements with Agilent’s Cary 60 UV/VIS Spectrometer.</p><h5><strong>5. Milestone: Unlock Smarter Digestion: AI and the Smart Features that Transform Your Daily Routine</strong></h5><ul><li>We, 1.7.2026 16:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/webinar/6312">Registration</a></li></ul><p>Learn how Milestone’s intelligent digestion technologies, including MAIA AI Agent, easyTEMP, and SRC, help reduce downtime, simplify workflows, and improve laboratory productivity.</p><h5><strong>6. Bruker: High-Energy XRD - Diffraction Without Limits</strong></h5><ul><li>Th, 2.7.2026 10:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/webinar/6314">Registration</a></li></ul><p>Join us to explore how high-energy XRD with the D8 ADVANCE HE and D8 DISCOVER HE enables the study of materials under realistic conditions.</p><h5><strong>7. Agilent Technologies: Spectral Flow Cytometry Masterclass - Session 1</strong></h5><ul><li>Fr, 3.7.2026 07:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/webinar/6316">Registration</a></li></ul><p>Learn how full-spectrum flow cytometry enables high-dimensional cell analysis. Explore spectral flow technology, experimental design, and applications in immunology, oncology, and vaccine research.</p>

Webinars LabRulezICPMS Week 27/2026

<p><strong>The international standard ISO/IEC 17025 [1] clause 7.7.2 with regards to ensuring the validity of results, requires a laboratory to participate in proficiency testing (PT) and/or to participate in interlaboratory comparisons (ILCs) other than PT. However, no guidance as to what these other ILCs might be, or indeed how they might compare in relation to PT, is provided. This leaflet aims to outline other ILCs available, pointing out some of the limitations as compared to PT.&nbsp;</strong></p><p>There are three major types of ILCs in which a group of laboratories analyses identical portions from a homogeneous, stable test sample, with each type being characterized by its intended purpose [2,3]:</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Eurachem_Interlaboratory_comparisons_other_than_proficiency_testing_2_d9263807fb.jpg" alt="Eurachem: Interlaboratory comparisons other than proficiency testing" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Eurachem_Interlaboratory_comparisons_other_than_proficiency_testing_2_d9263807fb.jpg 245w," sizes="100vw" width="1507" height="607"></p><p>A key point is that PT is an ILC that is designed to specifically evaluate the performance of participants, providing them with an infrastructure to monitor and assess the validity of their results. This is not the key purpose of the two other ILCs, and thus depending on their intended purpose they have a number of limitations that laboratories need to be aware of when using them rather than PT. Only proficiency testing should have been conducted in full compliance to the competency standard ISO/IEC 17043 [4].&nbsp;</p><h4><strong>Evaluation of measurement procedure performance&nbsp;</strong></h4><p>These ILCs, are designed to assess how a particular measurement procedure performs and whether it is fit for its intended purpose. These ILCs are often referred to as a ‘method performance study’ or a ‘collaborative study’ [2]. Some limitations of using such ILCs for monitoring laboratory performance as an alternative to PT are:&nbsp;</p><ul><li>All participants use the same measurement procedure i.e. the measurement procedure that is being validated. Unless the measurement procedure is being routinely used by the participating laboratory such an ILC will not assess the routine performance of the laboratory using their own routine measurement procedure. Nor does it enable them to compare their performance with other laboratories using alternative measurement procedures.&nbsp;</li><li>The measurement procedure is likely to be new, so participants may not have established stable procedures and quality control, so performance may not reflect routine use.&nbsp;</li><li>The report from such an ILC would not provide information on the performance of the participant, if the statistical model used makes the assumption that all laboratories perform with equal variability.</li><li>The design of the study may require the participants to assess multiple samples and/or to undertake multiple replicate analysis on the test materials. This may not be representative of the routine measurements or tests undertaken by the laboratory.&nbsp;</li><li>The conclusion of the ILC might be that the measurement procedure being assessed is not valid.&nbsp;</li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Eurachem_Interlaboratory_comparisons_other_than_proficiency_testing_3_a53ecd2f5d.jpg" alt="Eurachem: Interlaboratory comparisons other than proficiency testing" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Eurachem_Interlaboratory_comparisons_other_than_proficiency_testing_3_a53ecd2f5d.jpg 157w," sizes="100vw" width="570" height="566"></p><h4><strong>Characterisation of candidate reference materials&nbsp;</strong></h4><p>These are ILCs that assign a property value to a candidate reference material, usually with a stated measurement uncertainty. These are often referred to as a ‘material certification study’ [2]. Limitations of using such ILCs as an alternative to PT are:&nbsp;</p><ul><li>The analysis of the candidate reference material is likely to require additional care in exercising the routine measurement procedure, such as substantially more replication, and/or may require quite different reporting formats (e.g. all valid replicates instead of a mean result). Thus, such an ILC will not necessarily provide an evaluation of the performance of the laboratory based on the routine use of their measurement procedures.&nbsp;</li><li>The report from such an ILC may include the results from the participating laboratories but would not provide information on the performance of each laboratory.&nbsp;</li><li>Participating laboratories may be required to assess multiple samples and/or to undertake multiple replicate analysis on the candidate reference materials. Thus this may not be representative of the routine measurements or tests undertaken by the laboratory.&nbsp;</li></ul><h4><strong>Other ILCs&nbsp;</strong></h4><p>Some other ILCs, whilst not being conducted in full compliance of the requirements of ISO/IEC 17043, may be designed to evaluate participant performance. These would include small ILCs as defined by EA‑2/21 [5] or split sample ILCs i.e. where a portion of a single sample is sent to two or three laboratories. Whilst these ILCs are specifically designed to evaluate participant performance, they may not provide a comprehensive comparison that a PT might provide. In such cases the laboratory needs to evaluate carefully the competence of the organization managing the ILC and the suitability of the service externally provided (ISO/IEC 17025 clause 6.6).</p>

Interlaboratory comparisons other than proficiency testing

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Webinars

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Eurachem is a European network promoting international traceability of chemical measurements and good analytical practice. It provides expert guidance, supports method validation, uncertainty evaluation, proficiency testing, and facilitates discussion on technical and policy issues in analytical quality.

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Thermo Scientific ARL X’TRA Companion X-ray Diffractometer

Thermo Scientific™ ARL™ X’TRA Companion is a benchtop θ/θ Bragg–Brentano X-ray diffractometer for routine QC. 600 W (Cu/Co), pixel detector (55 × 55 µm), one-click Rietveld, ±0.02° accuracy.

<p><strong>The Thermo Scientific™ ARL™ X’TRA Companion is a θ/θ Bragg–Brentano benchtop X-ray diffractometer designed for routine process and quality control applications. The system combines high analytical performance with robust mechanical construction and intuitive software operation.</strong></p><p>The instrument is based on a <strong>vertical θ/θ Bragg–Brentano geometry</strong> (160 mm radius) and is suitable for qualitative and quantitative XRD analysis of polycrystalline materials. It operates at <strong>600 W</strong> using copper or cobalt radiation, with an optional integrated water chiller available.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_ARL_X_TRA_Companion_X_ray_Diffractometer_10_4ec7dc4708.jpg" alt="Thermo Scientific ARL X’TRA Companion X-ray Diffractometer: Schema of the geometry of the θ/θ goniometer." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_ARL_X_TRA_Companion_X_ray_Diffractometer_10_4ec7dc4708.jpg 245w," sizes="100vw" width="1338" height="626"></p><p><strong>Fast and resolute data acquisition</strong> is enabled by a state-of-the-art solid-state pixel detector (55 × 55 µm pitch). <strong>One-click Rietveld refinement </strong>based on a fundamental parameter approach ensures robust and reproducible phase quantification.<strong> Automated result transmission</strong> to LIMS is supported.</p><p>The system is<strong> fully shielded</strong> in accordance with <strong>international X-ray safety regulations </strong>and designed for stable operation even in environments exposed to vibration.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_ARL_X_TRA_Companion_X_ray_Diffractometer_3_b426717a92.jpg" alt="Thermo Scientific ARL X’TRA Companion X-ray Diffractometer" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_ARL_X_TRA_Companion_X_ray_Diffractometer_3_b426717a92.jpg 221w," sizes="100vw" width="1153" height="814"></p><h3><strong>Key Features</strong></h3><ul><li>θ/θ Bragg–Brentano geometry (160 mm radius)</li><li>600 W operation (Cu or Co radiation)</li><li>Solid-state pixel detector (55 × 55 µm pitch)</li><li>One-click Rietveld quantification (fundamental parameter approach)</li><li>Automated result transmission to LIMS</li><li>Mechanical slits, Soller slits and variable beam knife for precise beam collimation</li><li>Ultra-compact θ/θ goniometer with stepper motors and optical encoders</li><li>Modular design with exchangeable pre-aligned sample stages</li><li>Optional 6-position sample changer (φ 51.5 mm; optional φ 40 mm)</li><li>Angular accuracy better than ±0.02° over full 2θ range</li><li>Angular resolution &lt; 0.04° FWHM (standard configuration)</li><li>Shielded cabinet with lead glass windows, flushing lamps and safety interlocks</li><li>Robust construction resistant to shock and vibration</li><li>Data combination capability with XRF results</li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_ARL_X_TRA_Companion_X_ray_Diffractometer_11_fa2374532a.jpg" alt="Thermo Scientific ARL X’TRA Companion X-ray Diffractometer: An angular accuracy better than ± 0.02° over the whole 2θ range guarantees optimal instrument alignment to support accurate and reliable analysis. Test with a Si powder." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_ARL_X_TRA_Companion_X_ray_Diffractometer_11_fa2374532a.jpg 238w," sizes="100vw" width="872" height="573"><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_ARL_X_TRA_Companion_X_ray_Diffractometer_12_ec8343a5a4.jpg" alt="Thermo Scientific ARL X’TRA Companion X-ray Diffractometer: An angular resolution &lt; 0.04° FWHM can be measured easily in standard configuration. Test with a LaB₆ powder." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_ARL_X_TRA_Companion_X_ray_Diffractometer_12_ec8343a5a4.jpg 215w," sizes="100vw" width="870" height="630"></p><h4><strong>Analysis of Cement Clinker according to ASTM C1365</strong></h4><p>A clinker sample was measured (21 x 10 min) and a Rietveld fit was carried out consecutively using a fundamental parameter approach. Comparing standard deviations calculated from the repetitive refinements with limits given by ASTM C1365 clearly shows that results are in good agreement with the norm, as determined by considering C3A total and C3S total.</p><p>The ARL X’TRA Companion XRD yields data in compliance with ASTM C1365 norm for analyzing clinker samples. The one-click Rietveld refinement based on a fundamental parameter approach is an extremely robust method with high reproducibility which yields accurate results even for C3S M1 and M3. This makes clear the ARL X’TRA Companion is the perfect solution for any process control tasks in the cement industry.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_ARL_X_TRA_Companion_X_ray_Diffractometer_6_0d10ca1dc4.jpg" alt="Thermo Scientific ARL X’TRA Companion X-ray Diffractometer: Results of the 21 consecutive refinements of clinker (values in weight percent)." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_ARL_X_TRA_Companion_X_ray_Diffractometer_6_0d10ca1dc4.jpg 245w," sizes="100vw" width="1159" height="465"><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_ARL_X_TRA_Companion_X_ray_Diffractometer_7_8da3de0f8e.jpg" alt="Thermo Scientific ARL X’TRA Companion X-ray Diffractometer: Rietveld fit of clinker (10 min acquisition)." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_ARL_X_TRA_Companion_X_ray_Diffractometer_7_8da3de0f8e.jpg 170w," sizes="100vw" width="872" height="801"><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_ARL_X_TRA_Companion_X_ray_Diffractometer_8_9aad68624e.jpg" alt="Thermo Scientific ARL X’TRA Companion X-ray Diffractometer: Rietveld fit of clinker (29-35° 2θ)." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_ARL_X_TRA_Companion_X_ray_Diffractometer_8_9aad68624e.jpg 169w," sizes="100vw" width="868" height="800"><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_ARL_X_TRA_Companion_X_ray_Diffractometer_9_c7ceefee8d.jpg" alt="Thermo Scientific ARL X’TRA Companion X-ray Diffractometer: Measurement of clinker (55-61° 2θ). Fit for C3S M1 (purple) and C3S M3 (green) explains intensity and shape of the reflections well." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_ARL_X_TRA_Companion_X_ray_Diffractometer_9_c7ceefee8d.jpg 211w," sizes="100vw" width="871" height="643"></p>

Thermo Scientific SolstiX XRD Software with Security Suite

SolstiX™ XRD Software with Security Suite for ARL™ EQUINOX enables FDA 21 CFR Part 11 compliance with audit trails, digital signatures, and advanced data security.

<p><strong>Thermo Scientific™ SolstiX™ XRD Software with Security Suite is designed for the </strong><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/products?category=252&amp;manufacturerItems=3&amp;search=EQUINOX+"><strong>Thermo Scientific™ ARL™ EQUINOX X-ray diffractometer</strong></a><strong> range and enables compliance with 21 CFR Part 11 (Electronic Records / Electronic Signatures).</strong></p><p><strong>Security Suite Software</strong> integrates directly into SolstiX Software and provides <strong>advanced data security and integrity tools to meet regulatory requirements</strong>. The software logs changes to files associated with SolstiX Software, even when the software itself is not running.</p><h3><strong>Key Features</strong></h3><h4><strong>21 CFR Part 11 Compliance</strong></h4><ul><li>Meets FDA Code of Federal Regulations Title 21, Part 11 requirements</li><li>Designed using a strictly controlled Product Development Process (PDP)</li><li>Full traceability in specification, revision control, and software validation</li></ul><h4><strong>Full System Access Control</strong></h4><ul><li>Works with Windows security to authenticate operators</li><li>Software access controlled per user on single or multiple instruments</li><li>Can be configured per user, per system, or enterprise-wide</li></ul><h4><strong>True Digital Signatures</strong></h4><ul><li>Cryptographic user authentication</li><li>Encrypted secure hash validation of signed files</li><li>Detects file tampering</li><li>Digital signature history included in audit trails</li></ul><h4><strong>Complete Audit Trails</strong></h4><ul><li>Non-editable spectral data processing histories</li><li><strong>Tracks:</strong><ul><li>Changes to data by any operator</li><li>Digital signature history</li><li>Comments added to collection information</li><li>Data collection information</li><li>Errors during data collection</li></ul></li><li><strong>Event logging includes:</strong><ul><li>Security Administration database changes</li><li>Security Server activity</li><li>File creation, modification, renaming, deletion (even when software is not running)</li><li>Log-on, log-off, failed log-on</li><li>File signing and failed signing events</li></ul></li></ul><p>Entries include user name, date and time (with GMT reference), and reason for change. The history is embedded in the spectral data file and is not editable.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Solsti_X_XRD_Software_with_Security_Suite_3_d00e9f36ef.jpg" alt="Thermo Scientific SolstiX XRD Software with Security Suite: This comprehensive activity tracking and logging assures you the ability to create detailed audit trails for your XRD instrument, and the data it generates." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Solsti_X_XRD_Software_with_Security_Suite_3_d00e9f36ef.jpg 245w," sizes="100vw" width="1405" height="824"></p><h4><strong>Flexible Record Storage and Retrieval</strong></h4><ul><li>Automatic saving of original raw data</li><li>Enables reproduction of experiments</li><li><strong>Includes:</strong><ul><li>Final format data</li><li>Sample interferogram</li><li>Background interferogram</li></ul></li><li>Retrieval and review in <strong>Thermo Scientific™ OMNIC™ Software</strong> or database/graphical programs</li><li>Automatic saving without operator intervention</li><li>Archiving options</li><li>Copying spectra and reports in graphical format to external programs</li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Solsti_X_XRD_Software_with_Security_Suite_2_4426bcf334.jpg" alt="Thermo Scientific SolstiX XRD Software with Security Suite: Y₂O₃ powder diffractogram." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Solsti_X_XRD_Software_with_Security_Suite_2_4426bcf334.jpg 222w," sizes="100vw" width="1298" height="913"></p><h4><strong>Thermo Scientific Security Administration Server</strong></h4><p><strong>The Security Administration Server provides centralized control over:</strong></p><ul><li>Software access</li><li>System policies</li><li>Digital signature meanings</li></ul><p><strong>It can run:</strong></p><ul><li>Stand-alone on an XRD workstation</li><li>As a server application to administer one or multiple systems</li></ul><p><strong>Capabilities include:</strong></p><ul><li>Prevent overwriting of files</li><li>Require digital signatures on file saves</li><li>Require reason entry when data is changed</li><li>Prevent changing directories when opening/saving files</li><li>Automatically lock workstation after inactivity</li><li>Control access to software features</li><li>Add, delete, or edit signature meanings</li><li>Preview and print user settings for inspection</li></ul><p>The system allows high security while maintaining productivity. Once configured, settings can be locked to prevent modification.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Solsti_X_XRD_Software_with_Security_Suite_4_a1fff7a67c.jpg" alt="Thermo Scientific SolstiX XRD Software with Security Suite." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Solsti_X_XRD_Software_with_Security_Suite_4_a1fff7a67c.jpg 245w," sizes="100vw" width="1386" height="827"></p>

Thermo Scientific ARL iSpark Plus Inclusion Analyzer

High-performance spark OES analyzer enabling ultra-fast simultaneous analysis of elemental composition and non-metallic inclusions in steel for improved process control and product quality.

<p><strong>The Thermo Scientific™ ARL iSpark Plus Inclusion Analyzer with Spark-DAT technology provides ultra-fast and comprehensive analysis of non-metallic inclusions in steel. It enables simultaneous determination of elemental composition and inclusion characteristics within a single spark OES measurement. This capability allows near real-time monitoring of inclusion content during steel production, supporting process optimization, improved product quality, and prevention of costly issues such as nozzle clogging during continuous casting.</strong></p><p>Designed as a complete solution for steelmaking applications, the analyzer integrates advanced optical design, high-sensitivity detection, and dedicated software tools to evaluate inclusion <strong>type, size, concentration, and volume fraction</strong>.</p><h4><strong>Key features</strong></h4><ul><li><strong>Trusted ARL iSpark Plus spark OES platform</strong> for advanced inclusion and elemental analysis</li><li><strong>1 m Paschen-Runge optical system </strong>with photomultiplier tube (PMT) detectors</li><li>Full <strong>elemental coverage including gas elements</strong></li><li><strong>Ultra-fast inclusion analysis </strong>combined with elemental determination</li><li><strong>Determination of inclusion type, number, size, concentration, and volume fraction</strong></li><li><strong>Dedicated software tools:</strong> Spark Explorer, Inclusions Report, SPC</li><li><strong>Customizable inclusion analysis methods</strong> with expert training support</li><li><strong>Compatible with ARL SMS</strong> (Sample Manipulation System) for automated workflows</li></ul><h4><strong>Technical specifications</strong></h4><ul><li><strong>Frequency:</strong> 50/60 Hz</li><li><strong>Detector type: </strong>Photomultiplier Tubes (PMT)</li><li><strong>Application:</strong> Steelmaking</li><li><strong>Instrument type:</strong> Inclusion analyzer</li><li><strong>Exterior dimensions (H × W): </strong>1200 mm × 860 mm</li><li><strong>Weight: </strong>Approx. 500 kg</li></ul>

Thermo Scientific UniQuant Software for Standardless XRF Analysis

Thermo Scientific UniQuant Software for Standardless XRF Analysis enables fast and reliable elemental analysis of unknown materials without calibration and with minimal sample preparation.

<p><strong>Thermo Scientific™ UniQuant Software for Standardless XRF Analysis enables the characterization of unknown materials without the need for internal standards or certified reference materials. It delivers semi-quantitative to quantitative results by applying a methodology based on Fundamental Parameters combined with advanced proprietary algorithms for XRF data processing.</strong></p><p>The software is designed to handle a <strong>wide variety of sample types</strong>, including multi-element solids, pressed powders with or without binders, small samples on supporting films, liquids, and aerosol filters. This flexibility allows for reliable elemental identification and composition analysis<strong> within minutes</strong>.</p><ul><li>Sample preparation is typically minimal or not required. UniQuant can analyze up to <strong>79 elements, from boron to americium</strong>, including their oxide forms.&nbsp;</li><li>For each element, the <strong>software reports the standard deviation</strong> (sigma)<strong> in ppm</strong>, along with results expressed in weight percent and an estimated error.</li><li>To ensure accuracy, the software applies <strong>corrections for background, spectral interferences, line overlaps, matrix effects, and selected physical influences</strong>.&nbsp;</li><li>High-power measurements are generally completed in <strong>less than 14 minutes</strong>, while samples belonging to known material groups can be analyzed in as little as<strong> 5 minutes</strong>.</li><li>For applications requiring enhanced accuracy, specially<strong> calibrated datasets can be used</strong>.</li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Uni_Quant_Software_for_Standardless_XRF_Analysis_3_197f7b4da1.jpg" alt="Thermo Scientific UniQuant Software for Standardless XRF Analysis" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Uni_Quant_Software_for_Standardless_XRF_Analysis_3_197f7b4da1.jpg 86w," sizes="100vw" width="644" height="1167"></p><h4><strong>Thin Layer Samples</strong></h4><p>For mono-layer samples, UniQuant can <strong>simultaneously determine layer composition and sample mass</strong>, including the associated standard deviation. If the substrate contains elements present in the layer, their influence is automatically taken into account.</p><h4><strong>Interactivity</strong></h4><p>The user interface is optimized to<strong> minimize the number of steps </strong>required for operation. It also enables <strong>rapid adjustment of analytical assumptions</strong>, such as switching between sulfide and oxide models for unknown sample evaluation.</p><h4><strong>Batch Modes</strong></h4><p>Batch processing is supported for both calibration (set-up) samples and groups of unknown samples. Samples can be organized and tagged within directories, allowing the analysis process to be initiated efficiently.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Uni_Quant_Software_for_Standardless_XRF_Analysis_2_40a60cb3ff.jpg" alt="Thermo Scientific UniQuant Software for Standardless XRF Analysis: UniQuant Software uses peak to peak acquisition allowing for best limits of detection." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Uni_Quant_Software_for_Standardless_XRF_Analysis_2_40a60cb3ff.jpg 245w," sizes="100vw" width="1530" height="760"></p>

Thermo Scientific Nicolet iS20 FTIR Spectrometer

Nicolet iS20 FTIR spectrometer with LightDrive optics, <0.25 cm⁻¹ resolution, cloud connectivity, and advanced mixture analysis capabilities.

<p>The <strong>Thermo Scientific Nicolet™ iS™ 20 FTIR Spectrometer</strong> represents a <strong>next-generation FTIR platform</strong> designed for <strong>fast and accurate identification of mixtures, contaminants, and trace components</strong> across applications including <strong>QA/QC, pharmaceuticals, polymers, and forensics</strong>.</p><p>At the core of the system is the <strong>LightDrive™ Optical Engine</strong>, integrating the <strong>source, laser, interferometer, and detector</strong> into a single optimized module. This design delivers <strong>high spectral resolution (&lt;0.25 cm⁻¹)</strong> and a <strong>signal-to-noise ratio up to 50,000:1</strong>, enabling detection of low-level components.</p><p>The instrument features a <strong>touchscreen interface with multi-color LED status indicators (ready / scan / alert)</strong> for intuitive operation. A <strong>sealed and purge-ready optical bench</strong> ensures long-term stability even in demanding environments.</p><p>The system supports <strong>cloud-enabled workflows via Thermo Fisher Cloud</strong> and uses <strong>OMNIC™ / OMNIC Specta™ software</strong>, including a library of <strong>&gt;9,000 spectra</strong> for rapid unknown identification.</p><h4><span><strong>Key Features</strong></span></h4><ul><li>LightDrive™ optical engine (source, laser, interferometer, detector)</li><li>Spectral resolution &lt; 0.25 cm⁻¹</li><li>Signal-to-noise ratio up to 50,000:1</li><li>Touchscreen interface with LED status indicators</li><li>10-year warranty on source, laser, and interferometer</li><li>High data reproducibility (stable IR source)</li><li>Sealed, purge-ready optics</li><li>Cloud connectivity (Thermo Fisher Cloud)</li><li>OMNIC™ and OMNIC Specta™ software (&gt;9,000 spectra library)</li><li>Automated validation (IQ/OQ, pharmacopeias)</li><li>Wide accessory compatibility (SMART, microscopy, TGA-IR)</li></ul><h3><span><strong>Technical Specifications</strong></span></h3><h4><span><strong>Optics and Performance</strong></span></h4><ul><li><strong>Spectral range:</strong><ul><li>7800–350 cm⁻¹ (standard KBr)</li><li>11,000–375 cm⁻¹ (XT-KBr extended range)</li></ul></li><li><strong>Spectral resolution:</strong> &lt; 0.25 cm⁻¹</li><li><strong>Signal-to-noise ratio:</strong> 50,000:1</li><li><strong>Laser: solid-state diode laser (10-year warranty)</strong></li><li><strong>Beamsplitter:</strong><ul><li>KBr/Ge (standard)</li><li>XT-KBr/Ge (optional)</li></ul></li></ul><h4><span><strong>Detection and Sources</strong></span></h4><ul><li><strong>Detector:</strong><ul><li>DTGS (standard)</li><li>optional high-sensitivity detectors (e.g., MCT)</li></ul></li><li><strong>Source:</strong><ul><li>stabilized IR source (non-migrating hot spot)</li><li>optional tungsten/halogen</li></ul></li></ul><h4><span><strong>Construction and Validation</strong></span></h4><ul><li><strong>Optical system:</strong> sealed and purge-ready</li><li><strong>Validation:</strong> integrated SPV, ASTM/NIST traceable</li><li><strong>Compliance:</strong><ul><li>USP / Ph. Eur. / JP / CP</li><li>21 CFR Part 11</li></ul></li></ul><h4><span><strong>Interface and Software</strong></span></h4><ul><li>USB 2.0</li><li>Thermo Fisher Cloud</li><li>Software: OMNIC™ / OMNIC Specta™</li></ul><h4><span><strong>Dimensions and Weight</strong></span></h4><ul><li>Dimensions: 570 × 550 × 250 mm</li><li>Weight: 32 kg</li></ul><h4><span><strong>Electrical</strong></span></h4><ul><li>100–240 V, 50–60 Hz</li></ul>

Thermo Scientific Antaris II FT-NIR Analyzer

The Thermo Scientific Antaris™ II FT-NIR Analyzer enables fast, non-destructive analysis without sample preparation, supporting quality control, process monitoring, and method transfer.

<p><strong>The Thermo Scientific Antaris™ II FT-NIR Analyzer is a Fourier Transform Near-Infrared (FT-NIR) analyzer designed for quality control, process monitoring, and method development in industrial environments. Its rugged design and intuitive operation enable reliable analysis directly on the production floor, in warehouses, and in laboratory.</strong></p><p>The system combines analytical performance with flexibility, supporting seamless method development, transfer, and routine operation. The Antaris II platform ensures reproducible results regardless of configuration, user, or environment, making it ideal for standardized workflows and global deployments.</p><p>FT-NIR technology enables fast, non-destructive analysis without sample preparation, significantly improving efficiency and reducing operational costs.</p><h3><span><strong>Key Features</strong></span></h3><ul><li>FT-NIR spectroscopy for rapid, non-destructive analysis</li><li>Excellent method transferability between instruments</li><li>Rugged industrial design for harsh environments</li><li>Internal HeNe laser calibration – no external calibration required</li><li>Stable, frictionless Michelson interferometer</li><li>Automated workflows and SOP-driven operation</li><li>Fully compliant with regulated environments (GMP, 21 CFR Part 11)</li><li>Low cost of ownership and high reliability</li></ul><h3><span><strong>Sampling Capabilities</strong></span></h3><p><span>The system offers flexible sampling configurations that can be adapted to different material types and application requirements.</span></p><ul><li><strong>Reflectance measurements: </strong>solids, powders, pastes</li><li><strong>Transmission measurements: </strong>liquids, films, tablets</li><li>Fiber optics for in-line and remote measurements</li><li>Integrating sphere for diffuse reflectance</li><li>Tablet analyzer module</li><li>Automation options (up to ~120 samples per hour)</li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Antaris_II_FT_NIR_Analyzer_29c4d2264a.jpg" alt="Thermo Scientific Antaris II FT-NIR Analyzer" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Antaris_II_FT_NIR_Analyzer_29c4d2264a.jpg 245w," sizes="100vw" width="1584" height="314"></p><h3><span><strong>Software and Data Analysis</strong></span></h3><p>Support for multiple software platforms depending on application (routine analysis, method development, chemometrics)</p><ul><li><strong>RESULT software</strong> for routine operation and GMP environments</li><li><strong>OMNIC software </strong>for advanced spectral analysis</li><li><strong>The Unscrambler software</strong> for chemometric modeling and data interpretation</li></ul><h3><span><strong>Advantages of FT-NIR Technology</strong></span></h3><ul><li>No sample preparation required</li><li>Non-destructive analysis</li><li>Fast measurement times</li><li>High accuracy and reproducibility</li><li>Lower cost compared to wet chemistry and LC methods</li><li>Suitable for at-line and in-line analysis</li></ul><h3><span><strong>Technical Specifications</strong></span></h3><ul><li><strong>Analyzer Type:</strong> FT-NIR (Fourier Transform Near-Infrared)</li><li><strong>Spectral Range:</strong> 12,000 to 3,800 cm⁻¹ (833–2630 nm)</li><li><strong>Resolution:</strong> 4 cm⁻¹ (standard), 2 cm⁻¹ (optional)</li><li><strong>Detector:</strong> InGaAs</li><li><strong>Source:</strong> Long-life halogen NIR source</li><li><strong>Interferometer:</strong> Michelson, frictionless design</li><li><strong>Wavenumber Accuracy:</strong> ±0.03 cm⁻¹</li><li><strong>Repeatability:</strong> &lt;0.006 cm⁻¹</li><li><strong>Reproducibility (system-to-system):</strong> &lt;0.05 cm⁻¹</li><li><strong>Operating Temperature:</strong> 15–35 °C</li><li><strong>Dimensions (W × D × H):</strong> 40.6 × 68.5 × 33 cm</li><li><strong>Weight:</strong> 47.7 kg</li></ul><h3><span><strong>Typical Applications</strong></span></h3><ul><li>Pharmaceutical industry</li><li>Food and beverage analysis</li><li>Chemical industry</li><li>Polymer and materials analysis</li><li>Raw material identification</li><li>Process analytical technology (PAT, at-line, in-line)</li></ul>

Thermo Scientific Antaris MX FT-NIR Process Analyzer

The Thermo Scientific Antaris™ MX FT-NIR Process Analyzer enables real-time on-line and in-line monitoring, improving product quality, yield, and process efficiency.

<p><strong>The Thermo Scientific Antaris™ MX FT-NIR Process Analyzer is a Fourier Transform Near-Infrared (FT-NIR) analyzer designed for real-time on-line and in-line monitoring of industrial manufacturing processes. It enables continuous measurement of critical quality parameters directly in the process, allowing rapid response to deviations and improved production efficiency.</strong></p><p>Using fiber-optic technology and multi-point monitoring, the system can simultaneously measure multiple locations within a process using a single analyzer. This eliminates time delays between sampling points and provides true time-aligned data, which is essential for dynamic processes.</p><p>The Antaris MX is built for demanding production environments, offering high reliability, reproducibility, and seamless integration into process control systems.</p><h3><span><strong>Key Features</strong></span></h3><ul><li>FT-NIR spectroscopy for <strong>real-time process analysis</strong></li><li><strong>Simultaneous multi-point monitoring</strong> with a single analyzer</li><li>Fiber-optic sampling for remote measurements</li><li><strong>ParaLux™ technology </strong>with no mechanical channel switching</li><li>Continuous internal referencing (background correction)</li><li>High stability, sensitivity, and fast response time</li><li><strong>Rugged design</strong> for industrial environments</li><li>Low cost of ownership and high system uptime</li></ul><h3><span><strong>Sampling Capabilities</strong></span></h3><ul><li>Fiber-optic probes for in-line, on-line, and at-line applications</li><li>Reflectance, transmission, and transflectance measurements</li><li>Simultaneous monitoring of up to 4 process points</li><li>Manual and fully automated sampling</li><li>Specialized probes for fermentation, drying, and slurry processes</li><li>Retractable probes with automated cleaning options</li></ul><h3><span><strong>Software and Data Analysis</strong></span></h3><ul><li><strong>RESULT software </strong>for workflow control and automation</li><li><strong>TQ Analyst™</strong> for chemometric modeling and calibration transfer</li><li><strong>OPC communication </strong>for integration with SCADA/DCS systems</li><li><strong>Compatibility </strong>with LIMS, ERP, and tracking systems (RFID, barcode)</li><li><strong>Automated pass/fail </strong>decision-making</li></ul><h3><span><strong>Advantages of FT-NIR in Process Analysis</strong></span></h3><ul><li>Real-time process feedback</li><li>Non-destructive analysis without sample preparation</li><li>Improved product yield and quality</li><li>Reduced operational costs</li><li>Elimination of delays between measurement and decision</li><li>Support for fully automated process control</li></ul><h3><span><strong>Technical Specifications</strong></span></h3><ul><li><strong>Analyzer Type:</strong> FT-NIR (Fourier Transform Near-Infrared)</li><li><strong>Spectral Range:</strong> 12,000 to 3,800 cm⁻¹ (833–2500 nm)</li><li><strong>Resolution:</strong> 4 cm⁻¹ (standard), 2 cm⁻¹ (optional)</li><li><strong>Detector:</strong> InGaAs</li><li><strong>Source:</strong> Long-life halogen NIR source</li><li><strong>Interferometer:</strong> Michelson, frictionless design</li><li><strong>Wavenumber Accuracy:</strong> ±0.1 cm⁻¹</li><li><strong>Repeatability:</strong> &lt;0.006 cm⁻¹</li><li><strong>Reproducibility:</strong> &lt;0.05 cm⁻¹</li><li><strong>Operating Temperature:</strong> 15–35 °C</li><li><strong>Dimensions:</strong> 48.2 × 40.6 × 24.7 cm</li><li><strong>Weight:</strong> 25.8 kg</li></ul><h3><span><strong>Typical Applications</strong></span></h3><ul><li>Real-time process monitoring (on-line, in-line)</li><li>Raw material identification and control</li><li>Pharmaceutical and chemical industries</li><li>Fermentation and reaction monitoring</li><li>Quality control in production</li><li>Mobile and at-line analysis</li></ul>

Waters Aura PTx System for particle characterization

Aura PTx combines BMI and fluorescence microscopy to rapidly detect protein aggregates and polysorbate degradation from just 5 µL of sample.

<p><strong>The Aura PTx System is an innovative analytical platform designed to accelerate protein formulation development and stability screening for therapeutic drug development. Combining Backgrounded Membrane Imaging (BMI) and Fluorescence Membrane Microscopy (FMM) with dual fluorescence channels, the system enables rapid detection, counting, and characterization of protein aggregates and excipient degradation products within a single experiment.</strong></p><p>Unlike traditional imaging methods that rely solely on particle morphology, Aura PTx can distinguish protein and non-protein particles using fluorescence-based identification. The combination of <strong>Thioflavin T (ThT)</strong> and <strong>BODIPY FL C16</strong> staining enables simultaneous assessment of protein aggregation and polysorbate degradation, two critical indicators of biologic formulation stability.</p><p>Requiring only 5 µL of sample and supporting automated 96-well plate workflows, the Aura PTx System is ideally suited for high-throughput formulation screening during early-stage development of therapeutic proteins, monoclonal antibodies, and other biologics.</p><h3><strong>Key Features</strong></h3><ul><li>Combines BMI and FMM technologies in one platform</li><li>Dual fluorescence channels for simultaneous analysis</li><li>Distinguishes protein and non-protein particles</li><li>Detects and quantifies protein aggregates</li><li>Monitors polysorbate degradation</li><li>Simultaneous protein and excipient stability assessment</li><li>Requires only 5 µL sample volume</li><li>Automated 96-well plate workflow</li><li>High-throughput formulation screening</li><li>No cleaning required between measurements</li><li>Fast sample processing and analysis</li><li>Suitable for Design of Experiments (DoE)</li><li>Supports biologics development</li><li>Early detection of formulation stability issues</li></ul><h3><strong>Technical Specifications</strong></h3><h4><strong>Technology</strong></h4><ul><li>Backgrounded Membrane Imaging (BMI)</li><li>Fluorescence Membrane Microscopy (FMM)</li><li>Dual-channel fluorescence detection</li></ul><h4><strong>Optics</strong></h4><ul><li>Objective: 4×</li><li>Resolution: 1.0 pixel/µm</li><li>Imaging area: 24.6 mm²</li></ul><h4><strong>Particle Detection</strong></h4><ul><li>Detectable size range:<ul><li>1 µm (ECD)</li><li>&lt;5 mm (ECD)</li></ul></li></ul><h4><strong>Sample Handling</strong></h4><ul><li>Minimum sample volume: 5 µL</li><li>Compatible with 96-well plates</li><li>Optimized for high-throughput screening</li></ul><h4><strong>Analysis Speed</strong></h4><ul><li>BMI read time: 1 minute per sample</li><li>FMM read time: 30 seconds per sample</li></ul><h4><strong>Fluorescence Analysis</strong></h4><ul><li>Thioflavin T (ThT) for protein aggregate detection</li><li>BODIPY FL C16 for polysorbate degradation analysis</li><li>Simultaneous protein and excipient characterization</li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_The_Aura_P_Tx_System_tells_you_exactly_what_is_protein_via_Th_T_staining_and_what_is_not_even_in_mixed_particles_9cb34b80b1.jpg" alt="Waters: The Aura PTx System tells you exactly what is protein (via ThT staining) and what is not, even in mixed particles." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_The_Aura_P_Tx_System_tells_you_exactly_what_is_protein_via_Th_T_staining_and_what_is_not_even_in_mixed_particles_9cb34b80b1.jpg 234w," sizes="100vw" width="1024" height="682"></p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_The_Aura_P_Tx_System_is_the_first_to_use_thioflavin_T_Th_T_and_BODIPY_FL_C16_staining_to_detect_and_quantify_protein_aggregates_and_polysorbate_breakdown_fc113affba.jpg" alt="Waters: The Aura PTx System is the first to use thioflavin T (ThT) and BODIPY FL C16 staining to detect and quantify protein aggregates and polysorbate breakdown." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_The_Aura_P_Tx_System_is_the_first_to_use_thioflavin_T_Th_T_and_BODIPY_FL_C16_staining_to_detect_and_quantify_protein_aggregates_and_polysorbate_breakdown_fc113affba.jpg 234w," sizes="100vw" width="1024" height="682"></p><h4><strong>Software</strong></h4><ul><li>Particle Vue™ 4.x Software Suite</li><li>Integrated data analysis</li><li>Automated particle identification and characterization</li></ul><h4><strong>Typical Applications</strong></h4><ul><li>Biopharmaceutical development</li><li>Protein formulation screening</li><li>Monoclonal antibodies</li><li>Biosimilars</li><li>Stability studies</li><li>Excipient screening</li><li>Polysorbate degradation monitoring</li><li>Aggregate characterization</li><li>Design of Experiments (DoE)</li><li>Biologics quality control</li></ul>

Waters Aura GT System for particle characterization

Aura GT enables characterization of AAV and viral vectors from just 5 µL of sample, including detection of capsid and DNA aggregates using BMI and FMM technologies.

<p><strong>The Aura GT System is the first dedicated platform designed for the detection, counting, and characterization of viral vectors used in gene therapy, including AAV (Adeno-Associated Virus) and lentiviral vectors. Combining Backgrounded Membrane Imaging (BMI) and Fluorescence Membrane Microscopy (FMM) with dual fluorescence channels, the system enables rapid and reliable assessment of viral particle aggregation and stability during early-stage development.</strong></p><p>Requiring only <strong>5 µL of sample</strong>, Aura GT allows characterization even when only limited material is available. Using fluorescent dyes such as <strong>Thioflavin T (ThT)</strong> and <strong>SYBR™ Gold</strong>, researchers can distinguish capsid aggregates from DNA-containing aggregates, identify root causes of instability, and gain valuable insights into viral vector quality.</p><p>The system supports high-throughput 96-well plate screening and enables direct comparison of formulations, AAV serotypes, production lots, storage conditions, and stability profiles. Results that traditionally required months of work can now be obtained within hours.</p><h3><strong>Key Features</strong></h3><ul><li>Combines <strong>BMI and FMM technologies</strong> in one platform</li><li>Specifically designed for <strong>AAV, lentivirus, and viral vectors</strong></li><li>Detects, counts, and characterizes viral aggregates</li><li>Differentiates <strong>capsid and DNA aggregates</strong></li><li>Identifies root causes of aggregation and instability</li><li>Requires only <strong>5 µL sample volume</strong></li><li>Dual fluorescence channels for simultaneous characterization</li><li>High-throughput <strong>96-well plate screening</strong></li><li>Direct comparison of formulations, serotypes, and production lots</li><li>Viral vector stability assessment</li><li>Actionable results within hours</li><li>Eliminates labor-intensive traditional assays</li><li>Optimized for gene therapy development</li><li>High sensitivity and throughput</li></ul><h3><strong>Technical Specifications</strong></h3><h4><strong>Technology</strong></h4><ul><li>Backgrounded Membrane Imaging (BMI)</li><li>Fluorescence Membrane Microscopy (FMM)</li><li>Dual-channel fluorescence detection</li></ul><h4><strong>Optics</strong></h4><ul><li><strong>Objective:</strong> 4×</li><li><strong>Resolution: </strong>1.0 pixel/µm</li><li><strong>Imaging area: </strong>24.6 mm²</li></ul><h4><strong>Particle Detection</strong></h4><ul><li>Detectable size range:<ul><li>1 µm (ECD)</li><li>&lt;5 mm (ECD)</li></ul></li></ul><h4><strong>Sample Handling</strong></h4><ul><li><strong>Minimum sample volume: </strong>5 µL</li><li><strong>Compatible with 96-well plates</strong></li><li>Optimized for high-throughput screening</li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Get_your_gene_therapy_products_to_market_even_faster_with_Aura_GT_System_195d42d00b.jpg" alt="Waters: Get your gene therapy products to market even faster with Aura GT System." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Get_your_gene_therapy_products_to_market_even_faster_with_Aura_GT_System_195d42d00b.jpg 245w," sizes="100vw" width="1024" height="522"></p><h4><strong>Analysis Speed</strong></h4><ul><li><strong>BMI read time:</strong> 1 minute per sample</li><li><strong>FMM read time: </strong>30 seconds per sample</li><li>2 fluorescence channels</li></ul><h4><strong>Fluorescence Analysis</strong></h4><ul><li>Thioflavin T (ThT) for capsid aggregate detection</li><li>SYBR™ Gold for DNA detection</li><li>Simultaneous identification of protein and DNA aggregates</li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Identify_root_cause_and_characterize_AAV_particles_at_low_volume_with_Aura_GT_System_c3f1c6a334.jpg" alt="Waters: Identify root cause and characterize AAV particles at low volume with Aura GT System." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Identify_root_cause_and_characterize_AAV_particles_at_low_volume_with_Aura_GT_System_c3f1c6a334.jpg 234w," sizes="100vw" width="1024" height="683"></p><h4><strong>Software</strong></h4><ul><li>Particle Vue™ 4.x Software Suite</li><li>Image acquisition and analysis</li><li>Automated particle characterization</li></ul><h4><strong>Typical Applications</strong></h4><ul><li>Gene therapy development</li><li>AAV vector characterization</li><li>Lentiviral vectors</li><li>Stability studies</li><li>Aggregation studies</li><li>AAV serotype comparison</li><li>Formulation screening</li><li>Production lot evaluation</li><li>DNA aggregate analysis</li><li>Viral vector development</li></ul>

Waters Aura CL System for particle characterization

Waters Aura CL rapidly identifies cells, aggregates, and residual Dynabeads™ from just 5 µL of sample while assessing viability and purity in cell therapy workflows.

<p><strong>The Aura CL System is the first dedicated platform designed for rapid identification, counting, and characterization of subvisible particles in cell therapy development and manufacturing. Unlike traditional methods, it can reliably distinguish viable cells, unwanted particles, protein aggregates, and manufacturing-related contaminants such as Dynabeads™, while simultaneously providing cell counts, viability information, and sample purity assessment.</strong></p><p>The system combines <strong>Backgrounded Membrane Imaging (BMI)</strong>, <strong>Fluorescence Membrane Microscopy (FMM)</strong>, and <strong>Side Illumination Membrane Imaging (SIMI)</strong> technologies to deliver fast, automated particle analysis without subjective operator interpretation. Through fluorescence labeling, users can clearly differentiate cellular from non-cellular particles, protein from non-protein aggregates, and various cell populations within complex samples.</p><p>Requiring only <strong>5 µL of sample</strong>, Aura CL supports high-throughput screening and can analyze up to 96 samples in less than one hour, making it an ideal solution for cell therapy development, manufacturing, and quality control workflows.</p><h3><strong>Key Features</strong></h3><ul><li>Combines <strong>BMI, FMM, and SIMI </strong>technologies</li><li>Automated identification of <strong>cells and non-cell particles</strong></li><li>Detection and counting of residual<strong> Dynabeads™</strong></li><li>Cell viability assessment</li><li>Characterization of subvisible particles</li><li>Differentiates <strong>protein and non-protein aggregates</strong></li><li>Distinguishes<strong> cellular and non-cellular particles</strong></li><li>Requires only<strong> 5 µL sample volume</strong></li><li>High-throughput <strong>96-well plate screening</strong></li><li>Fully automated analysis workflow</li><li>Results within minutes</li><li>Supports cell therapy development and manufacturing</li><li>Greater accuracy than manual hemocytometry</li><li>Reduces human interpretation errors</li></ul><h3><strong>Technical Specifications</strong></h3><h4><strong>Technology</strong></h4><ul><li>Backgrounded Membrane Imaging (BMI)</li><li>Fluorescence Membrane Microscopy (FMM)</li><li>Side Illumination Membrane Imaging (SIMI)</li></ul><h4><strong>Optics</strong></h4><ul><li><strong>Objectives:</strong><ul><li>4×</li><li>10×</li></ul></li><li><strong>Resolution: </strong>1.0 pixel/µm</li><li><strong>Imaging area:</strong> 24.6 mm²</li></ul><h4><strong>Particle Detection</strong></h4><ul><li>Detectable size range:<ul><li>1 µm (ECD)</li><li>&lt;5 mm (ECD)</li></ul></li></ul><h4><strong>Sample Handling</strong></h4><ul><li><strong>Minimum sample volume: </strong>5 µL</li><li>Compatible with 96-well plates</li><li>Optimized for high-throughput screening</li></ul><h4><strong>Analysis Speed</strong></h4><ul><li><strong>BMI read time: </strong>1 minute per sample</li><li><strong>FMM read time: </strong>30 seconds per sample</li></ul><h4><strong>Fluorescence Analysis</strong></h4><ul><li>Cell and non-cell particle identification</li><li>Cell viability measurements</li><li>Protein aggregate detection</li><li>Non-protein particle detection</li><li>Fluorescent antibody and cell labeling applications</li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_With_Aura_CL_System_you_can_achieve_high_throughput_and_definitive_identification_of_viable_cells_and_take_the_guesswork_out_of_cell_viability_assessments_a46a5ee8b4.jpg" alt="Waters: With Aura CL System, you can achieve high-throughput and definitive identification of viable cells and take the guesswork out of cell viability assessments." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_With_Aura_CL_System_you_can_achieve_high_throughput_and_definitive_identification_of_viable_cells_and_take_the_guesswork_out_of_cell_viability_assessments_a46a5ee8b4.jpg 234w," sizes="100vw" width="1024" height="682"></p><h4><strong>Software</strong></h4><ul><li>Particle Vue™ 4.x Software Suite</li><li>Image acquisition and analysis</li><li>Automated particle classification</li><li>Viability and purity assessment tools</li></ul><h4><strong>Typical Applications</strong></h4><ul><li>Cell therapy development</li><li>CAR-T manufacturing</li><li>Cell product quality control</li><li>Residual Dynabeads™ detection</li><li>Cell viability testing</li><li>Cell culture purity monitoring</li><li>Subvisible particle characterization</li><li>Biologics development</li><li>Lot release testing</li><li>Manufacturing process control</li></ul>

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