The Aura PTx System is an innovative analytical platform designed to accelerate protein formulation development and stability screening for therapeutic drug development. Combining Backgrounded Membrane Imaging (BMI) and Fluorescence Membrane Microscopy (FMM) with dual fluorescence channels, the system enables rapid detection, counting, and characterization of protein aggregates and excipient degradation products within a single experiment.
Unlike traditional imaging methods that rely solely on particle morphology, Aura PTx can distinguish protein and non-protein particles using fluorescence-based identification. The combination of Thioflavin T (ThT) and BODIPY FL C16 staining enables simultaneous assessment of protein aggregation and polysorbate degradation, two critical indicators of biologic formulation stability.
Requiring only 5 µL of sample and supporting automated 96-well plate workflows, the Aura PTx System is ideally suited for high-throughput formulation screening during early-stage development of therapeutic proteins, monoclonal antibodies, and other biologics.
Waters: The Aura PTx System tells you exactly what is protein (via ThT staining) and what is not, even in mixed particles.
Waters: The Aura PTx System is the first to use thioflavin T (ThT) and BODIPY FL C16 staining to detect and quantify protein aggregates and polysorbate breakdown.
