Manufacturer
Waters
Waters
Waters creates business advantages for laboratory-dependent organizations by delivering ultra performance liquid chromatography (UPLC), high-performance liquid chromatography (HPLC), chromatography columns and chemistry products, mass spectrometry systems, laboratory informatics solutions, and comprehensive service programs to enable significant advancement in healthcare delivery, environmental management, food safety, and water quality.
Distributor
Waters Corporation (Europe)
Waters makes scientific ambitions a reality through the application of HPLC, MS and TA instruments, consumables, and informatics as well as industry-leading scientific expertise.
Waters Aura CL System for particle characterizationWaters Aura CL rapidly identifies cells, aggregates, and residual Dynabeads™ from just 5 µL of sample while assessing viability and purity in cell therapy workflows.
Features

Waters Aura CL System for particle characterization

The Aura CL System is the first dedicated platform designed for rapid identification, counting, and characterization of subvisible particles in cell therapy development and manufacturing. Unlike traditional methods, it can reliably distinguish viable cells, unwanted particles, protein aggregates, and manufacturing-related contaminants such as Dynabeads™, while simultaneously providing cell counts, viability information, and sample purity assessment.

The system combines Backgrounded Membrane Imaging (BMI), Fluorescence Membrane Microscopy (FMM), and Side Illumination Membrane Imaging (SIMI) technologies to deliver fast, automated particle analysis without subjective operator interpretation. Through fluorescence labeling, users can clearly differentiate cellular from non-cellular particles, protein from non-protein aggregates, and various cell populations within complex samples.

Requiring only 5 µL of sample, Aura CL supports high-throughput screening and can analyze up to 96 samples in less than one hour, making it an ideal solution for cell therapy development, manufacturing, and quality control workflows.

Key Features

  • Combines BMI, FMM, and SIMI technologies
  • Automated identification of cells and non-cell particles
  • Detection and counting of residual Dynabeads™
  • Cell viability assessment
  • Characterization of subvisible particles
  • Differentiates protein and non-protein aggregates
  • Distinguishes cellular and non-cellular particles
  • Requires only 5 µL sample volume
  • High-throughput 96-well plate screening
  • Fully automated analysis workflow
  • Results within minutes
  • Supports cell therapy development and manufacturing
  • Greater accuracy than manual hemocytometry
  • Reduces human interpretation errors

Technical Specifications

Technology

  • Backgrounded Membrane Imaging (BMI)
  • Fluorescence Membrane Microscopy (FMM)
  • Side Illumination Membrane Imaging (SIMI)

Optics

  • Objectives:
    • 10×
  • Resolution: 1.0 pixel/µm
  • Imaging area: 24.6 mm²

Particle Detection

  • Detectable size range:
    • 1 µm (ECD)
    • <5 mm (ECD)

Sample Handling

  • Minimum sample volume: 5 µL
  • Compatible with 96-well plates
  • Optimized for high-throughput screening

Analysis Speed

  • BMI read time: 1 minute per sample
  • FMM read time: 30 seconds per sample

Fluorescence Analysis

  • Cell and non-cell particle identification
  • Cell viability measurements
  • Protein aggregate detection
  • Non-protein particle detection
  • Fluorescent antibody and cell labeling applications

Waters: With Aura CL System, you can achieve high-throughput and definitive identification of viable cells and take the guesswork out of cell viability assessments.Waters: With Aura CL System, you can achieve high-throughput and definitive identification of viable cells and take the guesswork out of cell viability assessments.

Software

  • Particle Vue™ 4.x Software Suite
  • Image acquisition and analysis
  • Automated particle classification
  • Viability and purity assessment tools

Typical Applications

  • Cell therapy development
  • CAR-T manufacturing
  • Cell product quality control
  • Residual Dynabeads™ detection
  • Cell viability testing
  • Cell culture purity monitoring
  • Subvisible particle characterization
  • Biologics development
  • Lot release testing
  • Manufacturing process control
Manufacturer
Waters
Waters
Waters creates business advantages for laboratory-dependent organizations by delivering ultra performance liquid chromatography (UPLC), high-performance liquid chromatography (HPLC), chromatography columns and chemistry products, mass spectrometry systems, laboratory informatics solutions, and comprehensive service programs to enable significant advancement in healthcare delivery, environmental management, food safety, and water quality.
Distributor
Waters Corporation (Europe)
Waters makes scientific ambitions a reality through the application of HPLC, MS and TA instruments, consumables, and informatics as well as industry-leading scientific expertise.
 

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