Discover how the iCAP PRO ICP-OES helps reduce method complexity, maintain stability with challenging matrices, and gain faster sample insight using AI-powered SemiQuantFor decades, ICP-OES has been a trusted workhorse for laboratories analyzing everything from clean water to complex brine, alloys, organics, and other challenging matrices. But today’s laboratories are being asked to do more: meet stricter regulatory and industry requirements, process more samples, reduce turnaround time, develop methods for complex samples, and improve workflow efficiency.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Fisher_Scientific_How_to_Simplify_ICP_OES_Analysis_Method_Development_High_Matrix_Samples_and_Daily_Operation_f6b97f35e6.jpg" alt="Thermo Fisher Scientific: How to Simplify ICP-OES Analysis: Method Development, High Matrix Samples, and Daily Operation" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Fisher_Scientific_How_to_Simplify_ICP_OES_Analysis_Method_Development_High_Matrix_Samples_and_Daily_Operation_f6b97f35e6.jpg 245w," sizes="100vw" width="1024" height="512">That is where next-generation ICP-OES technology can make a meaningful difference.The <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/products?category=227&amp;manufacturerItems=3&amp;search=PRO">Thermo Scientific iCAP PRO Series ICP-OES</a> is designed to help laboratories improve productivity, robustness, sensitivity, and ease of use — while introducing intelligent, AI-powered tools that give analysts faster insight into their samples.In the on-demand webinar, “<a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/webinar/6198">Time to Go PRO: Discover the future of ICP-OES analysis</a>,” Thermo Fisher Scientific experts take ICP users inside the iCAP PRO ICP-OES platform for a practical virtual demonstration of the hardware, software, and differentiating technologies that support modern trace elemental analysis.<h3>Small footprint, big laboratory benefits</h3>Laboratory space is valuable, and ICP-OES instruments need to fit efficiently into busy workflows. The iCAP PRO ICP-OES features a compact vertical design that helps conserve bench space while keeping maintenance and service areas easy to access.Key benefits include:<ul><li>Space-saving vertical footprint that allows the instrument to sit flush against the wall.</li><li>Front and side access to routine maintenance points and service connections.</li><li>Simplified installation, service, and maintenance.</li><li>Streamlined sample introduction system with familiar, quick-connect components.</li><li>A smoother transition for laboratories currently using previous iCAP systems.</li></ul>For ICP analysts, the result is a system designed not only for performance but also for everyday usability.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Fisher_Scientific_How_to_Simplify_ICP_OES_Analysis_Method_Development_High_Matrix_Samples_and_Daily_Operation_2_dd16d95db6.jpg" alt="Thermo Fisher Scientific: How to Simplify ICP-OES Analysis: Method Development, High Matrix Samples, and Daily Operation" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Fisher_Scientific_How_to_Simplify_ICP_OES_Analysis_Method_Development_High_Matrix_Samples_and_Daily_Operation_2_dd16d95db6.jpg 245w," sizes="100vw" width="1000" height="553"><h3>Robust performance for high-matrix samples</h3>High-matrix samples and high-throughput workloads are common in industrial, environmental, materials, and contract testing laboratories. To keep up, an ICP-OES system must maintain plasma stability, reduce drift, and minimize downtime.The iCAP PRO ICP-OES is built with design features that support robust, reliable operation across demanding sample types.<h3>Optimized vertical torch designed for extended stability and uptime</h3>The iCAP PRO ICP-OES vertical torch design optimizes airflow within the torch box to support a stable, matrix-tolerant plasma. This helps reduce deposition on the torch and injector, which can support longer, more stable analytical runs.For ICP analysts, the benefits are clear:<ul><li>Reduced signal drift</li><li>Fewer sample failures and reruns</li><li>Less matrix buildup on key components</li><li>Reduced maintenance-related downtime</li><li>Long-term stability and reliability when analyzing challenging samples</li></ul>If cleaning is needed, the passivated aluminum torch box can be removed with just three screws, making maintenance more straightforward.<h3>Purged Optical Path for efficient UV transmission</h3>The iCAP PRO ICP-OES also uses a Purged Optical Path, or POP, interface to help maintain efficient light transmission from the plasma to the spectrometer. Low-flow argon purge gas exits through ceramic axial and radial POP nozzles, creating a protected optical path that helps reduce UV absorption by air and helps prevent plasma byproducts, dust, soot, and sample material from reaching the optical system.This is especially important for ICP-OES analysis because many critical emission lines are in the UV range.Key benefits include:<ul><li>Improved UV sensitivity.</li><li>Lower detection limits for important elements such as arsenic, selenium, and lead.</li><li>Reduced contamination of the optical interface.</li><li>No need for a separate shear gas supply or air compressor.</li><li>Simplified operation and lower running complexity.</li></ul><h3>Mirror protection for long-term optical performance</h3>The intense ultraviolet light produced by the plasma can gradually degrade optical mirrors over time. To help protect the optical system, the iCAP PRO ICP-OES uses an automated beam blocker that shields mirrors from unnecessary UV exposure when measurements are not being taken.This helps support:<ul><li>Long-term optical stability.</li><li>Reduced mirror wear.</li><li>Lower maintenance requirements.</li></ul><h3>High-efficiency optics and detection for confident results</h3>The iCAP PRO Series ICP-OES combines a compact, high-efficiency optical design with proprietary Charge Injection Device, or CID, detector technology to help maximize sensitivity, speed, and confidence in results.The optimized optical path helps transmit more light from the plasma to the detector, while the 5th generation CID821 detector captures high-quality spectral information across the wavelength range with more than 2 million pixels and smaller pixel size than in the previous iCAP platform.Together, these technologies support:<ul><li>Efficient light transmission</li><li>Improved sensitivity</li><li>Better spectral resolution</li><li>Faster analysis</li><li>More confident results in complex matrices</li></ul><h3>The CID detector advantage: more spectral detail, less compromise</h3>In real-world ICP-OES analysis, a single sample can contain trace-level analytes that produce weak signals and major matrix elements that produce very intense emission lines. The detector must manage both at the same time.That is where CID detector technology provides a significant advantage.The iCAP PRO ICP-OES CID821 smaller pixel size and high pixel density help improve physical separation between adjacent wavelengths, giving analysts more flexibility when choosing emission lines and background correction points. This also makes it easier to resolve trace analytes from nearby matrix lines, such as trace molybdenum in a tungsten matrix or trace lead in high-concentration copper.For the ICP-OES user, this means:<ul><li>Better peak separation</li><li>Easier background correction</li><li>Reduced spectral overlap</li><li>Less reliance on correction strategies and mathematical equations</li><li>Greater confidence in complex sample analysis.</li></ul><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Fisher_Scientific_How_to_Simplify_ICP_OES_Analysis_Method_Development_High_Matrix_Samples_and_Daily_Operation_3_e3e0cb27d9.jpg" alt="Thermo Fisher Scientific: How to Simplify ICP-OES Analysis: Method Development, High Matrix Samples, and Daily Operation" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Fisher_Scientific_How_to_Simplify_ICP_OES_Analysis_Method_Development_High_Matrix_Samples_and_Daily_Operation_3_e3e0cb27d9.jpg 245w," sizes="100vw" width="768" height="357"><h3>Why anti-blooming matters in ICP-OES</h3>Instruments have advanced significantly from classical Paschen-Runge, or Rowland Circle, spectrometers that used individual photomultiplier tubes, or PMTs, positioned at fixed wavelengths. While effective, these systems required larger optical layouts and offered less flexibility because each PMT was dedicated to a specific emission line. The transition to solid-state chip detectors, known as Charge Transfer Devices, or CTDs, helped make ICP-OES instruments more compact, flexible, and information-rich by enabling many wavelengths to be captured across a detector array. This shift supported faster multi-element analysis, easier wavelength selection, improved method development, and access to full-spectrum data from a smaller instrument platform. The two primary CTD technologies used in ICP-OES are the Charge-Coupled Device, or CCD, and the CID.In CTD detector-based ICP-OES, photons from emission lines are converted into electrical charge within individual pixels. When an intense emission line saturates a detector region, excess charge can spread into neighboring pixels, an effect known as blooming. In CCD detectors, where charge is shifted pixel by pixel across the chip during readout, blooming can distort nearby weaker signals and lead to overestimation of their intensity.The CID detector within the iCAP PRO ICP-OES works differently. In a CID, each pixel is an independent site with its own set of electrodes. The electrical charge generated by incoming light is collected and stored directly inside that specific pixel. If a pixel fills to capacity, the excess charge drains into the underlying silicon substrate rather than spilling into neighboring pixels. Pixels are addressed individually and read without shifting charge across the array, helping contain intense signals. In this way, CID detectors are inherently anti-blooming.For analysts, anti-blooming helps protect trace-level analyte peaks near strong matrix emission lines. This can reduce the need to choose less sensitive wavelengths, add extra dilutions, or rely on additional correction strategies that may increase method complexity.Additionally, because the charge doesn’t have to move across the chip to be read (unlike a CCD), a CID can perform Non-Destructive Readout (NDRO) where the CID detector can measure the charge in an individual pixel without emptying it. For ICP-OES analysis, this provides two important benefits.<ul><li>First, weak emission lines can be integrated for a longer time to collect more signal.</li><li>Second, bright emission lines can be monitored during the exposure and read before they approach saturation.</li></ul>In practical terms, NDRO helps the CID detector capture weak trace-level signals more effectively while managing intense matrix lines — improving signal-to-noise ratio resulting to better sensitivity, extending dynamic range, and leading to more confident trace-level results.The blooming effect experienced in CCD detectors can be minimized by setting integration times, segmenting the detector, or by adding anti-blooming or overflow drains. These approaches can help reduce the impact of very intense emission lines on weaker trace-level signals and reduce blooming, but they are mitigation strategies rather than the inherent pixel-level readout advantage of CID technology.<h3>Intelligent Full Range and enhanced UV modes</h3>The larger CID detector also enables Intelligent Full Range, or iFR, mode, which captures the full elemental spectrum in one simultaneous acquisition. This reduces analysis time by eliminating sequential low- and high-wavelength exposures.For applications requiring improved UV performance, enhanced UV, or eUV, mode provides added sensitivity for key elements with emission lines in the low UV range.<h3>Key takeaways from the optical and detector design</h3>The practical benefits of the iCAP PRO ICP-OES compact optical design combined with the unique and proprietary CID technology are clear:<ul><li>High sensitivity,</li><li>Faster analysis,</li><li>Reduced spectral interferences,</li><li>Better performance in high-matrix samples, and</li><li>Greater confidence in the analysis of complex sample matrices.</li></ul>The same rich, simultaneous spectral data captured by the CID detector also helps power advanced software capabilities such as the innovative AI-driven SemiQuant, giving analysts rapid insight into unknown samples without having to build a calibration curve.<h3>AI-powered SemiQuant: instant sample insight</h3>One of the most compelling parts of the on-demand webinar is the software demonstration, including a deep dive into the new AI-powered SemiQuant feature within the<a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/products/1489"> Thermo Scientific Qtegra Intelligent Scientific Data Solution (ISDS) software</a>.Traditional ICP-OES method development often starts with several questions: Which elements are present? What concentration ranges should be expected? Which wavelengths should be selected? What interferences might occur? Which samples need dilution?AI-powered SemiQuant helps answer those questions faster. Using the rich, simultaneous spectral information captured by the CID detector, SemiQuant evaluates many wavelengths for each element rather than relying on a single emission line. The AI model interprets these spectral patterns to provide rapid, semi-quantitative concentration estimates without requiring instrument calibration.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Fisher_Scientific_How_to_Simplify_ICP_OES_Analysis_Method_Development_High_Matrix_Samples_and_Daily_Operation_4_56ce880ee0.jpg" alt="Thermo Fisher Scientific: How to Simplify ICP-OES Analysis: Method Development, High Matrix Samples, and Daily Operation" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Fisher_Scientific_How_to_Simplify_ICP_OES_Analysis_Method_Development_High_Matrix_Samples_and_Daily_Operation_4_56ce880ee0.jpg 245w," sizes="100vw" width="768" height="409">For ICP users, this provides immediate insight into unknown samples.The SemiQuant feature can help analysts quickly assess:<ul><li>What elements are present.</li><li>Which elements are high or low in concentration.</li><li>What calibration ranges to build.</li><li>Which matrix components may cause spectral interferences.</li><li>Which samples may need dilution before quantitative analysis.</li><li>How to streamline method development and sample preparation.</li></ul>This makes AI-powered SemiQuant especially valuable for sample screening, unknown identification, method development, contamination investigations, and troubleshooting before committing to a full quantitative workflow<h3>Watch the on-demand iCAP PRO ICP-OES technical showcase</h3>The on-demand virtual technical showcase gives ICP users an insider’s look at the iCAP PRO ICP-OES from both the hardware and software perspective.In the hardware demonstration, you will see:<ul><li>The compact vertical instrument design</li><li>The vertical torch and torch box access</li><li>The simplified sample introduction system</li><li>Maintenance and user-friendly design features</li><li>How analysts interact with the instrument during routine operation</li></ul><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Fisher_Scientific_How_to_Simplify_ICP_OES_Analysis_Method_Development_High_Matrix_Samples_and_Daily_Operation_5_4485b11821.jpg" alt="Thermo Fisher Scientific: How to Simplify ICP-OES Analysis: Method Development, High Matrix Samples, and Daily Operation" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Fisher_Scientific_How_to_Simplify_ICP_OES_Analysis_Method_Development_High_Matrix_Samples_and_Daily_Operation_5_4485b11821.jpg 245w," sizes="100vw" width="768" height="480">In the Qtegra ISDS software demonstration, you will see:<ul><li>How to develop a method</li><li>Wavelength selection</li><li>Acquisition settings</li><li>Interference correction tools</li><li>Sample list setup</li><li>AI-powered SemiQuant analysis</li><li>A deep dive into how SemiQuant provides fast insight into unknown samples</li></ul>Whether you are running environmental samples, industrial materials, or high-salt brines, the iCAP PRO Series ICP-OES is designed to help your laboratory move from sample to reliable result with greater speed, confidence, and ease.Register now to watch the on-demand virtual technical showcase, “<a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/webinar/6198">Time to Go PRO: Discover the future of ICP-OES analysis</a>,” and get firsthand insight from our application experts into the innovations that make the iCAP PRO ICP-OES our most powerful, user-friendly instrument yet. To learn more, visit the <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/products?category=227&amp;manufacturerItems=3&amp;search=PRO">iCAP PRO Series ICP-OES</a> instruments.<blockquote>Visit us on&nbsp;<a target="_blank" rel="noopener noreferrer" href="https://www.linkedin.com/showcase/72003132/admin/dashboard/">LinkedIn:</a>&nbsp;#ICP-OES #ElementalAnalysis #MetalsAnalysis #AtomicSpectroscopy</blockquote>

How to Simplify ICP-OES Analysis: Method Development, High Matrix Samples, and Daily Operation

In this leaflet we discuss whether or not you should correct for an observed significant bias and the impact this may have on the measurement uncertainty (MU). How to apply the correction and how to increase the uncertainty to take account of an uncorrected bias is outside the scope of this leaflet.&nbsp;Important issues for deciding on how to treat an observed significant bias are:&nbsp;<ul><li>whether we understand the cause of the bias, and&nbsp;</li><li>whether its size can be reliably determined.&nbsp;</li></ul>Further we must decide:&nbsp;<ul><li>whether the bias is consistent for all test samples within the scope of the method and&nbsp;</li><li>whether any correction for bias should be multiplicative or additive, depending on whether the magnitude of the bias is constant or changes with the concentration level.</li></ul><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Eurachem_Treatment_of_an_observed_bias_2_d221a32b8b.jpg" alt="Eurachem: Treatment of an observed bias" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Eurachem_Treatment_of_an_observed_bias_2_d221a32b8b.jpg 245w," sizes="100vw" width="1528" height="448"><h4>Should we correct, and should we increase the measurement uncertainty?&nbsp;</h4>The ISO Guide to the expression of uncertainty in measurement, GUM [1], assumes that “the result of a measurement has been corrected for all recognised significant systematic effects” (GUM 3.2.4). This implies that when developing a measurement method all known sources of bias should be investigated and if possible, eliminated or their effect minimised. If this cannot be achieved, then, if appropriate, a correction should be applied and the measurement uncertainty revised.&nbsp;Let’s assume we have available a standardised method or a fully developed in-house method, with a clear description of the measurand, where any known bias has been minimised during method development (e.g. the effect of interferences has been minimised or a correction is included in the method). The next step, as a part of the validation, is to reliably determine any additional bias for the concentration interval and different matrices specified within the scope of the method. On the next page we present a roadmap outlining how to handle any additional significant bias.&nbsp;Note that the observed bias in a laboratory could be due to laboratory as well as method bias. For empirical methods where the measurand is operationally defined by the method, the method bias is by definition zero, however, the laboratory bias still needs to be considered.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Eurachem_Treatment_of_an_observed_bias_3_5d99940abd.jpg" alt="Eurachem: Treatment of an observed bias" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Eurachem_Treatment_of_an_observed_bias_3_5d99940abd.jpg 62w," sizes="100vw" width="426" height="1060"><ol><li>There is no point in trying to eliminate or correct a small bias, since both elimination and correction need resources.&nbsp;</li><li>If bias is not negligible then the best approach, if possible, is to try to eliminate it by modifying the method.&nbsp;</li><li>If bias is not negligible, but eliminating it is either impossible or impractical, then we can consider correcting for bias. There are three possibilities:&nbsp;<ul><li>Correction may be required (e. g. by regulations).&nbsp;</li><li>Correction may be forbidden, in which case no correction should be made.&nbsp;</li><li>Correction may be allowed. Then we should look at two more criteria to determine whether correction is justified.&nbsp;</li></ul></li><li>If bias can be reliably determined and a correction method can be applied that is relevant for all test samples within the scope of the method we may decide to correct for bias. However, if the cause of bias is not known then correcting for bias cannot be generally recommended. If bias cannot be reliably determined then we should not correct for it. If we correct the result on the basis of an unreliable bias estimate then we may even increase the uncertainty of the results.&nbsp;</li><li>Correcting for bias is meaningful only if a useful reduction of measurement uncertainty (MU) is achieved. Correcting for the bias is only meaningful if the MU of the correction is smaller than the component of the MU arising from not applying the correction.&nbsp;</li></ol>If a significant bias is not corrected, it is difficult to give clear guidance on what action to take. For the case of recovery correction, IUPAC [2] lists some possibilities if no correction is applied:&nbsp;<ol><li>No action;&nbsp;</li><li>Report recovery separately, including the uncertainty of both the result and the recovery&nbsp;</li><li>Take the bias into account in the uncertainty estimate of the results</li></ol>These principles can be applied to other forms of bias. Further options have also been reviewed in the literature: See, for example, reference [3]

Treatment of an observed bias

Our Library never stops expanding. What are the most recent contributions to LabRulezICPMS Library in the week of 3rd August 2026? Check out new documents from the field of spectroscopy/spectrometry and related techniques!<blockquote>👉 <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/library">SEARCH THE LARGEST REPOSITORY OF DOCUMENTS ABOUT SPECTROSCOPY/SPECTROMETRY RELATED TECHNIQUES</a></blockquote><blockquote>👉 Need info about different analytical techniques? Peek into <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/library">LabRulezLCMS</a> or <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library">LabRulezGCMS</a> libraries.</blockquote>This week we bring you application notes by Agilent Technologies and Shimadzu and other document by Thermo Fisher Scientific!<h3>1. Agilent Technologies: Determination of Toxic Elements in Durian and Jackfruit Using an Agilent Automated ICP-MS System According to China GB 5009.268</h3><ul><li>Application note</li><li><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/labrulez-bucket-strapi-h3hsga3/an_icpms_durian_5994_9351en_agilent_fcafe537c7.pdf">Full PDF for download</a>&nbsp;</li></ul>Fruit is an essential part of daily human nutrition, providing vital vitamins, minerals, and dietary fiber.3 The Chinese market, with over 1.4 billion people, has become one of the largest fruit markets in the world. It is expected that China's total fruit consumption will reach about 312 million tons by 2025.4 Additionally, fruit imports are projected to exceed 9 million tons annually, underscoring the country's strong domestic demand and reliance on imported supplies.&nbsp;Within this context, China has become a major export destination for Asian countries, including Vietnam, Thailand, Laos, Cambodia, Philippines, Indonesia, and others. Thanks to favorable climate conditions and a wide variety of tropical fruit cultivars, these countries have strategically increased their fruit exports to satisfy Chinese market demand. Specifically, products such as durian and jackfruit have gained significant popularity, playing an increasingly vital role in regional agricultural trade.&nbsp;However, the biggest challenge for those countries when entering the Chinese market is strict food safety regulations, especially limits on trace elements and heavy metals such as lead (Pb), cadmium (Cd), mercury (Hg), and arsenic (As). The General Administration of Customs of the People's Republic of China (GACC) sets very low Maximum Residue Limits (MRLs, Table 1). Additionally, the large, continuous volume of fruit exports makes time a critical factor, as any delay can affect product quality and reduce its economic value. This situation places significant pressure on testing laboratories, requiring the development of stable, rapid, and accurate methods to ensure continuous and reliable operations.&nbsp;To address these challenges, the Agilent ICP Workflow Automation System offers a practical solution. The ICP‑MS 7900 provides high-throughput, highly sensitive, and precise measurements of trace elements and heavy metals, including Pb, Cd, Hg, and As. The combination of ADS2 and AVS helps reduce sample turnaround time and cost per analysis. The Advanced Dilution System (ADS2) automatically performs important tasks such as preparing a multipoint calibration from a single stock standard up to 400 times, diluting samples above the calibration range, or, if there is an internal standard recovery issue, eliminating the need for manual dilution. The Advanced Valve System (AVS) automatically rinses the sample introduction system while the next sample is being analyzed, virtually eliminating the delays typical of conventional analysis. Using controlled argon bubble injection between the sample and rinse solution prevents mixing, reducing uptake and rinse times. This study describes the use of the <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/library?mainauthorItems=10&amp;search=7900">Agilent 7900 ICP-MS</a>, <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/library?mainauthorItems=10&amp;search=SPS+4">Agilent SPS 4 autosampler</a>, AVS, and ADS2 auto-dilution for the analysis of four toxic elements in durian and jackfruit samples using the China GB 5009.268 method.1<h4>Results and discussion&nbsp;</h4><h5>Automatic calibration standards and Instrument stability&nbsp;</h5>A 7-point calibration curve automatically prepared using the ADS 2 demonstrated excellent linearity over the concentration range of 0.05–10 µg/L. Using a 1/x weighted regression without forcing the calibration through the origin, all analytes achieved coefficients of determination (R²) ≥ 0.995 (Figure 3), with back-calculated concentrations within 90–110% of their theoretical values, confirming the suitability of the calibration range for routine quantification. The integrated automation workflow significantly improved laboratory productivity by completing calibration preparation and analysis in approximately 1.5 minutes per sample. By minimizing manual operations and operator intervention, the ADS 2 reduced the risk of contamination and human error while enabling higher sample throughput for routine food safety testing.&nbsp;To evaluate instrument stability during continuous operation, the variation in internal standard recoveries was monitored throughout an analytical sequence of more than 70&nbsp;consecutive samples. The recoveries of the three internal standards across different measurement modes remained consistently within the ±20% acceptance limit throughout the analytical sequence (Figure 4). Blank samples interspersed between concentration intervals showed no evidence of carryover, demonstrating effective system cleanliness and analytical robustness. These results confirm the excellent long-term stability and robust matrix tolerance of the Agilent 7900 ICP-MS, providing reliable performance for high-throughput routine food safety testing.<h4>Conclusion&nbsp;</h4>The Agilent 7900 ICP-MS, integrated with the SPS 4 autosampler, ADS 2, and AVS, delivers a fully automated, high-throughput workflow for routine trace-level multi-element analysis. By eliminating manual standard preparation and minimizing operator intervention, the solution reduces labor costs, improves data consistency, and empowers laboratories to maximize productivity and analytical capacity to meet increasing testing demands.&nbsp;Excellent sensitivity, long-term stability, and robust interference removal, together with satisfactory recoveries, repeatability, and reproducibility for As, Cd, Pb, and Hg at an LOQ of 5 µg/kg, demonstrate reliable analytical performance. Compliance with Chinese regulatory requirements further position the Agilent automation solution as a cost-effective platform for high-volume food safety testing and export quality assurance, enabling laboratories to confidently support the growing demand for exports to the Chinese&nbsp;market.<h3>2. Shimadzu: TOC Evaluation of Surfactants</h3><ul><li>Application note</li><li><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/labrulez-bucket-strapi-h3hsga3/an_01_01160_en_539fba0ba2.pdf">Full PDF for download</a></li></ul><h5>User benefits</h5><ul><li>TOC can be evaluated accurately using the TC-IC method, even for foaming surfactants.&nbsp;</li><li>The ASI-L autosampler enables automatic, continuous measurement of multiple samples, improving analytical efficiency.</li></ul>Surfactants are important chemicals widely used in detergents and dispersants for pharmaceutical equipment cleaning processes, chemical manufacturing processes, and environmental water management. If surfactant residues remain after such processes, they can not only affect manufacturing processes and final product quality, but also increase the organic load in wastewater and environmental water. Therefore, quality control is also needed for organic matter derived from surfactants.&nbsp;Total organic carbon (TOC) analysis is effective for evaluating the quality of surfactants. In general, the NPOC (non-purgeable organic carbon) method is often selected for TOC measurement in terms of sample volume and analysis time requirements. On the other hand, because surfactants have both hydrophilic and hydrophobic groups in their structure, they tend to foam even at low concentrations. When such samples are measured by the NPOC method, which involves acid addition and sparging, foaming can cause the sample to overflow from the syringe vessel inside the instrument into the waste line. That can result in measurement valuesthat are lower than the true value.&nbsp;This article compares TOC measurement results for surfactants obtained by the NPOC method and the TC-IC method using the <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/library?mainauthorItems=1&amp;search=TOC-L">Shimadzu TOC-L total organic carbon analyzer</a>, which uses the combustion oxidation method.<h4>Conclusion&nbsp;</h4>Table 5 summarizes the results obtained by measuring sodium dodecylbenzenesulfonate solutions, used here as representative surfactant samples, by the NPOC method and the TC-IC method. With the NPOC method, the TOC recovery rates were below 50 % for all samples, whereas the TC-IC method produced satisfactory TOC recovery rates close to 100 % for all samples.Sodium dodecylbenzenesulfonate solutions (carbon concentration: 0.5 mg/L) is also used in Japanese Pharmacopoeia (JP) recovery tests. For surfactants that readily foam, such as in this example, NPOC measurements involving acid addition and sparging may affect measurement accuracy due to sample loss. For such samples, accurate TOC values can be obtained by using the TC-IC method. In addition, by using the ASI-L autosampler, multiple samples can be measured automatically and continuously.<h3>3. Thermo Fisher Scientific: How rhodium plating can affect gold XRF results</h3><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/products?category=315&amp;manufacturerItems=3&amp;search=niton">Thermo Scientific™ Niton™ XRF Analyzers</a> can help precious metals professionals detect rhodium (Rh) plating and interpret gold (Au) results with confidence.<ul><li>Other document (smart note)</li><li><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/labrulez-bucket-strapi-h3hsga3/rhodium_plating_can_affect_gold_xrf_results_sn1862_en_331edc099a.pdf">Full PDF for download</a></li></ul><h4>Benefits of XRF in jewelry analysis&nbsp;</h4>Niton XRF analyzers provide capabilities that can enhance a jeweler’s operations in several ways:&nbsp;<ul><li>Identify Rh-plated gold items during routine testing&nbsp;</li><li>Reduce confusion around unexpected Au readings&nbsp;</li><li>Support more confident buying, selling, refining, and verification decisions&nbsp;</li><li>Help explain results to customers, suppliers, and trading partners&nbsp;</li></ul><h4>Reduce risk in precious metals trading&nbsp;</h4>In precious metals trading, small differences in reported gold concentration can affect pricing, settlement, customer trust, and supplier relationships. Recognizing Rh plating helps users avoid unnecessary disputes, retesting, or destructive testing when the surface finish is influencing the measurement.&nbsp;<h4>Best practices&nbsp;</h4>One should always check the result for Rh when Au appears lower than expected.&nbsp;<ul><li>Test multiple locations, especially where plating may vary&nbsp;</li><li>Look for worn or unplated areas when appropriate&nbsp;</li><li>Interpret Au results in the context of surface finish and item history&nbsp;</li><li>If appropriate, remove the rhodium plating prior to XRF analysis to evaluate the underlying alloy&nbsp;</li></ul><h4>The bottom line&nbsp;</h4>Rhodium plating can make a properly karated gold item appear to return a lower Au result when it is evaluated by XRF. <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/products?category=315&amp;manufacturerItems=3&amp;search=niton">Niton XRF analyzers</a> can detect Rh at the surface, helping precious metals professionals recognize plating, interpret results correctly, and make more confident decisions.

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LECO 836 Series Elemental Analysis for Oxygen, Nitrogen, and Hydrogen Detection

LECO ONH836 Series delivers precise oxygen, nitrogen, and hydrogen analysis in metals and inorganic materials using inert gas fusion, advanced detectors, automation, and Cornerstone® software.

The ONH836 Oxygen/Nitrogen/Hydrogen Elemental Analyzer is designed for precise, wide-range determination of oxygen, nitrogen, and hydrogen in inorganic materials, ferrous and non-ferrous alloys, and refractory materials using inert gas fusion. Advanced automation combined with LECO’s Cornerstone® touch-screen software streamlines routine analysis, while a robust instrument design ensures long-term reliability in demanding laboratory environments.<h4>Available Models</h4>The ONH836 product family includes multiple configurations to match specific analytical requirements:<ul><li>ONH836 – Oxygen, Nitrogen, and Hydrogen Analyzer</li><li>ON836 – Oxygen and Nitrogen Analyzer</li><li>OH836 – Oxygen and Hydrogen Analyzer</li><li>O836 – Oxygen Analyzer</li><li>H836 – Hydrogen Analyzer</li><li>H836EN – High-precision Hydrogen Analyzer</li><li>N836 – Nitrogen Analyzer</li><li>NH836 – Nitrogen and Hydrogen Analyzer</li><li>O836Si – Oxygen Analyzer for Silicon Wafers</li></ul><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/LECO_rada_836_Analyza_prvku_pro_detekci_kysliku_dusiku_a_vodiku_5_8011397ce6.jpg" alt="LECO 836 Series" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_LECO_rada_836_Analyza_prvku_pro_detekci_kysliku_dusiku_a_vodiku_5_8011397ce6.jpg 134w," sizes="100vw" width="657" height="764"><h4>Key Features and Design Highlights</h4>The ONH836 Series is engineered to maximize analytical performance, stability, and ease of use:<ul><li>Robust sample loading area minimizes atmospheric contamination and simplifies routine maintenance</li><li>Triple infrared (IR) detection cells for oxygen measurement provide one of the widest detection ranges available</li><li>Automation options increase laboratory productivity and reduce manual handling</li><li>Optional autocleaner minimizes manual cleaning between analyses</li><li>20-position shuttle loader supports both crucibles and samples</li><li>Boom-mounted touch-screen interface improves ergonomics and intuitive operation</li><li>State-of-the-art non-dispersive infrared (NDIR) and thermal conductivity (TC) detectors<ul><li>No moving parts</li><li>No manual adjustments required</li></ul></li><li>Improved TC cell stability through:<ul><li>Bypassable OMI-2 carrier gas scrubber</li><li>Patented Dynamic Flow Compensation (DFC) technology</li></ul></li></ul><h4>Special Purpose Configurations</h4><h5>H836EN Model</h5>Designed for high-precision, low-level hydrogen determination, particularly in aluminum:<ul><li>Optimized for trace hydrogen in aluminum, ferrous alloys, titanium, and other materials</li><li>Software-controlled stepped temperature furnace profiles for speciation of surface and bulk hydrogen</li><li>EN-specific sample drop, upper electrode, and crucibles support large low-level samples such as aluminum slugs or depleted uranium pellets</li><li>Direct replacement for the RHEN602 Hydrogen Determinator</li></ul><h5>O836Si Model</h5>Developed for ultra-low oxygen determination in high-purity materials:<ul><li>Exceptional low-level sensitivity using solid-state IR detection</li><li>Novel sample loading design with programmable impulse furnace</li><li>Ideal for:<ul><li>Silicon wafer analysis</li><li>High-purity metals</li><li>Electronics and semiconductor applications</li></ul></li></ul><h4>Theory of Operation</h4>The ONH836 system performs simultaneous, wide-range analysis of oxygen, nitrogen, and hydrogen in steels, refractory metals, and other inorganic materials.A pre-weighed sample is placed into a graphite crucible and heated in an impulse furnace. Oxygen reacts with the graphite crucible to form carbon monoxide and carbon dioxide. An inert carrier gas, typically helium, transports the released analyte gases through a mass flow controller and into the detection system.<ul><li>Oxygen detection<ul><li>CO and CO₂ are measured using multiple NDIR cells for maximum accuracy across a wide concentration range</li></ul></li><li>Hydrogen detection<ul><li>CO is oxidized to CO₂ and hydrogen to H₂O in a heated reagent stage</li><li>Resulting H₂O and CO₂ are measured by a second set of NDIR cells</li></ul></li><li>Nitrogen detection<ul><li>CO₂ and H₂O are removed from the gas stream</li><li>Nitrogen remains as the only impurity and is measured using a thermal conductivity (TC) detector</li></ul></li></ul>LECO’s patented Dynamic Flow Compensation system adds makeup carrier gas to compensate for gas losses during scrubbing, ensuring stable TC detection. Quantitative results are calculated relative to calibration standards, with reference carrier gas measurements performed before each analysis to minimize drift and ensure reproducibility.

LECO 832 Series Combustion analysis for Sulfur and Carbon determination

High-performance elemental determinator for fast, precise carbon and sulfur analysis by combustion, featuring advanced IR detection, optional dual-range sulfur, and intuitive Cornerstone® touchscreen software.

The LECO 832 Series elemental determinators are engineered to deliver high productivity, analytical precision, and long-term reliability for the determination of carbon and sulfur in a wide range of organic and selected inorganic materials. By combining robust combustion technology with advanced infrared detection and the intuitive Cornerstone® touchscreen software platform, the 832 Series supports fast, accurate analysis while optimizing laboratory workflows.Its compact yet rugged design minimizes bench space requirements while providing excellent usability and operational control. A high-efficiency combustion furnace, enhanced IR detector stability, and intelligent system control make the 832 Series a dependable solution for laboratories requiring consistent, high-quality carbon and sulfur results.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/LECO_832_series_9d28085115.jpg" alt="LECO 832 Series" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_LECO_832_series_9d28085115.jpg 235w," sizes="100vw" width="416" height="276"><h4>Key Features and System Capabilities</h4><h5>Automated Sample Handling</h5>An optional autoloader significantly improves laboratory efficiency by enabling unattended operation. The autoloader accommodates up to 100 samples and is built with a rugged mechanical design to ensure reliable long-term performance. Automated handling simplifies operator workflows while maintaining consistent, rapid analysis cycle times.<h5>Enhanced Infrared Detection Performance</h5>The 832 Series incorporates an improved infrared (IR) cell design that delivers increased signal stability and measurement precision. Independent, wide-range IR detectors are dedicated to carbon and sulfur, ensuring optimized sensitivity across a broad concentration range. Enhanced temperature control, electrical isolation, and updated circuitry further improve detector performance and reliability.<h5>Dual-Range Sulfur Detection Option</h5>For laboratories analyzing samples with widely varying sulfur concentrations, optional dual-range (DR) sulfur detection provides extended measurement flexibility. This configuration employs both short and long optical path length IR cells, allowing accurate quantification of both high- and low-level sulfur within a single system. The software automatically selects the appropriate detection path to ensure optimal results.<h5>High-Efficiency Combustion Furnace</h5>The furnace system is engineered for maximum combustion efficiency and durability. Intelligent temperature control allows operating temperatures of up to 1550 °C, ensuring complete oxidation of even refractory materials. The furnace design supports rapid heating, stable operation, and long service life.<h5>Simplified Maintenance Access</h5>Routine maintenance tasks are streamlined through easy access to key service areas. This design minimizes downtime and reduces the overall cost of ownership while supporting consistent analytical performance.<h4>Application Areas</h4>The LECO 832 Series is suitable for a wide range of industrial, environmental, and research applications, including:<ul><li>Coal and coke</li><li>Combustion residues and biomass materials</li><li>Catalyst materials</li><li>Cement, hydrated lime, and building materials</li><li>Soils, ores, ceramics, glass, and gypsum</li><li>Fertilizers, feeds, and plant tissue</li><li>Rubber, resins, and polymers</li><li>Graphite</li><li>Petroleum products and additives</li></ul><h4>Principle of Operation</h4>The 832 Series is designed to determine carbon and sulfur content using high-temperature combustion followed by non-dispersive infrared (NDIR) detection. The technique is applicable to a wide variety of organic materials, such as coal, coke, and fuel oils, as well as selected inorganic materials including soils, cement, and limestone.Analysis begins with the sample being weighed into a ceramic combustion boat and introduced into the furnace, typically regulated at 1350 °C under a pure oxygen atmosphere. During combustion, carbon is oxidized to carbon dioxide (CO₂), while sulfur-containing compounds are converted to sulfur dioxide (SO₂).After an initial combustion period, additional oxygen is delivered directly above the sample via a ceramic lance to accelerate oxidation of refractory materials. Combustion gases pass through the inner and outer furnace tubes, extending their residence time in the high-temperature zone to ensure complete oxidation.Upon exiting the furnace, gases flow through anhydrone drying tubes to remove moisture before entering the flow control system. The regulated gas stream is then directed through the NDIR detection cells for carbon and/or sulfur measurement.NDIR detection is based on the selective absorption of infrared radiation by CO₂ and SO₂ at characteristic wavelengths. In dual-range sulfur models, both short and long path length IR cells are used to accommodate wide sulfur concentration ranges. The software automatically selects the appropriate cell for optimal quantification.All calculations, data processing, and result storage are managed by the Cornerstone® software running on an external PC, with concentrations determined relative to calibration standards.<h4>Available Models</h4><ul><li>S832 – Sulfur Analyzer</li><li>S832DR – Dual-Range Sulfur Analyzer</li><li>S832HT – High-Temperature Dual-Range Sulfur Analyzer</li><li>C832 – Carbon Analyzer</li><li>SC832 – Carbon and Sulfur Analyzer</li><li>SC832DR – Dual-Range Carbon and Sulfur Analyzer</li><li>SC832HT – High-Temperature Dual-Range Carbon and Sulfur Analyzer</li></ul>

LECO 828 Series: Macro Combustion Analysis for C, H, N, and Protein Determination

The LECO 828 Series Macro Combustion Analyzers provide fast, reliable determination of carbon, hydrogen, nitrogen, and protein.

<h3>LECO 828 Series – Macro Combustion Analysis for Carbon, Hydrogen, Nitrogen, and Protein</h3>The LECO 828 Series macro combustion analyzers represent an industry-leading solution for the determination of carbon, hydrogen, nitrogen, and protein across a wide range of sample types. Designed for laboratories that demand high throughput, robustness, and analytical reliability, the 828 Series combines advanced hardware with the intuitive Cornerstone® touchscreen software platform to support efficient routine and research workflows.Building on the proven performance of earlier LECO macro combustion instruments, the 828 Series introduces significant improvements in sample throughput, system uptime, and long-term operational reliability. With rapid analysis cycle times of as little as 2.8 minutes and the ability to handle macro-scale samples, the system is ideally suited for high-volume laboratories processing diverse matrices.For expanded analytical flexibility, all 828 Series instruments can be equipped with the S832 add-on module, enabling independent sulfur determination and further extending the scope of applications supported by a single analyzer.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/LECO_rada_828_Makroanalyza_spalovanim_pro_analyzator_uhliku_vodiku_dusiku_a_bilkovin_e86acd897e.jpg" alt="LECO 828 Series" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_LECO_rada_828_Makroanalyza_spalovanim_pro_analyzator_uhliku_vodiku_dusiku_a_bilkovin_e86acd897e.jpg 137w," sizes="100vw" width="454" height="516"><h3>Available Models</h3>The LECO 828 Series is offered in multiple configurations to match specific analytical requirements:<ul><li>FP828 – Nitrogen and Protein Analyzer</li><li>FP828P – Performance Nitrogen and Protein Analyzer</li><li>CN828 – Carbon and Nitrogen Analyzer</li><li>CNH828 – Carbon, Hydrogen, and Nitrogen Analyzer</li></ul><h3>System Options and Enhancements</h3>To further optimize laboratory workflows, the following options are available:<ul><li>S832 add-on module for sulfur determination</li><li>Cornerstone® Mobile for remote system monitoring</li><li>SmartLine™ Remote Diagnostics</li><li>Boom-mounted touchscreen monitor</li><li>Performance Package for enhanced throughput and efficiency</li></ul><h3>Key Benefits and Performance Features</h3><h4>Maximized Laboratory Productivity</h4>The 828 Series is engineered to support high sample throughput and short turnaround times. Rapid combustion and detection cycles—down to 2.8 minutes for FP and CN models—enable laboratories to analyze more samples per day without compromising data quality.<h4>Exceptional Reliability and System Uptime</h4>Extended reagent lifetimes and a robust mechanical design minimize unscheduled downtime and reduce the frequency of routine maintenance. This ensures stable, continuous operation even in demanding, high-volume environments.<h4>Lower Maintenance and Operating Costs</h4>The analyzer is designed with easy access to routine maintenance areas, allowing service tasks to be completed quickly and efficiently. The reagent-free furnace design further reduces operational costs by eliminating consumable reagents and simplifying system upkeep.<h4>High Sample Capacity with Automated Operation</h4>A rugged 30-position autoloader supports unattended operation, with optional expansion to accommodate up to 120 samples. This enables consistent, hands-free processing of large sample batches while minimizing operator intervention.<h4>Operator-Focused Ergonomic Design</h4>An ergonomic, boom-mounted touchscreen interface allows operators to control the system comfortably from a standing position. This design improves usability, reduces physical strain, and helps prevent handling errors during routine operation.<h4>Highly Efficient Furnace Technology</h4>The vertical quartz furnace used in the 828 Series is optimized for complete and efficient combustion. Its reagent-free design ensures consistent oxidation performance, high analytical accuracy, and long-term reliability without the need for additional consumables.<h3>Application Areas</h3>The versatility of the LECO 828 Series makes it suitable for a broad range of industries and sample types, including:<ul><li>Feeds, pet foods, grains, and cereals</li><li>Milled and processed food products</li><li>Protein-rich materials such as fermentation products, dairy whey, and cheese</li><li>Soils, sediments, fertilizers, and plant tissue</li><li>Waste materials, resins, polymers, biomass, coal, and coke</li><li>Petroleum products and chemical additives</li></ul><h3>Principle of Operation</h3>The LECO 828 Series employs a macro combustion technique using a vertical quartz furnace to determine elemental composition in a wide variety of organic matrices, including foods, feeds, soils, and fuels.Samples are weighed into tin capsules or encapsulated in tin foil and loaded into the analyzer. Once introduced, the system executes a fully automated analytical sequence. The sample first enters a sealed purge chamber, where atmospheric gases are removed to prevent analytical interference.Following purging, the sample is transferred into the combustion furnace and oxidized rapidly in a high-purity oxygen environment. The resulting combustion gases are then routed through the detection system. Depending on the analyzer configuration, carbon is measured as carbon dioxide (CO₂), nitrogen as nitrogen gas (N₂), and hydrogen as hydrogen gas (H₂).For sulfur determination, when equipped with the appropriate configuration, the system includes an afterburner stage that removes sulfur-containing compounds from the gas stream prior to detection.This automated, high-efficiency workflow delivers excellent analytical precision, fast cycle times, and reproducible results, reinforcing the LECO 828 Series as a dependable solution for modern elemental analysis laboratories.

Thermo Scientific™ GS Omni Analyzer

Thermo Scientific GS Omni uses PGNAA to provide continuous, calibration-free elemental analysis of process streams. Designed for demanding industrial slurry applications.

The Thermo Scientific™ GS Omni Light Element Analyzer provides robust, accurate elemental analysis for multiple process streams, delivering real-time information for the optimization of slurry beneficiation processes such as froth flotation. Utilizing industry-leading Prompt Gamma Neutron Activation Analysis (PGNAA) technology, it measures both heavy and light elements, crucially covering the Z&lt;20 elements – calcium and lighter – that are less well-suited to X-Ray Fluorescence (XRF) analysis. Together, Thermo Scientific PGNAA and XRF analyzers allow customers to measure the broadest possible range of elements.Since the PGNAA signal is unaffected by particle size, ore matrix or inter-element interference, the GS Omni requires no recalibration as the ore changes, enabling robust measurement with minimal cost and ongoing effort. Easily configured for between two and eight process streams, it provides data that you can confidently rely on. Use the GS Omni to control contaminant elements, improve product quality, increase recovery, and lower production costs.The GS Omni offers near metallurgical quality analysis for up to eight process streams, depending on concentration, elements of interest, required cycle analysis time, plant layout, and process control considerations.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_GS_Omni_Analyzer_927ddc6cd4.jpg" alt="Thermo Scientific™ GS Omni Analyzer" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_GS_Omni_Analyzer_927ddc6cd4.jpg 237w," sizes="100vw" width="650" height="427"><h3>🔑 Key features include:</h3><ul><li>Capability to measure light elements such as calcium, chlorine, sulfur, aluminum, silicon, magnesium, and sodium, for industrially relevant analysis over an extended range of elements relative to XRF.</li><li>Unaffected by matrix effects and particle size – unlike XRF – for robust measurements in the face of process changes and ore variability with no requirement for recalibration.</li><li>Scintillation detectors eliminate the need for cooling apparatus, enabling simpler set-up and operation with no requirement for chillers or special environmental control.</li><li>Modular multiplexer, for expansion from 2 to 8 streams.</li><li>Holding tank and sample recirculation through the measurement zone provide deaeration, which along with multiple passes through PGNAA source delivers more accurate measurement for slurry streams.</li><li>Factory calibrated for slurry applications with only infrequent site checks required, enabling minimal manual input and low maintenance.</li></ul>

Thermo Scientific™ FLASH 2000 CHNS/O Analyzers

The FLASH 2000 CHNS/O analyzer combines simplicity, precision, and low operating costs. Offers up to 12 configurations for a broad range of applications across science and industry.

<div><div>Decades of experience combined with our constant innovation in developing organic elemental analyzers (OEAs) contributed to the design of the Thermo Scientific™ FLASH 2000 CHNS/O Analyzers. This system delivers the ultimate in simplicity, precision, and cost effectiveness for any laboratory requiring the quantification of carbon, hydrogen, nitrogen, sulfur, and oxygen.Providing a reliable, high-speed, accurate 24/7 analytical solution to a range of industries, this series of flexible, configurable analyzers uses a globally recognized technique endorsed by official organizations worldwide.</div><div><h3>An Elemental Analysis Solution for a Range of Industries</h3>With an extraordinary range of applications, the modular design of the FLASH 2000 Series OEAs enables 12 configurations tailored to the fields of application they serve.<ul><li>Organic or inorganic chemistry and pharmaceuticals</li><li>Petrochemistry and energy</li><li>Environmental analysis</li><li>Material characterization</li><li>Agronomy and marine science</li><li>Food industry</li><li>Human and animal samples</li><li>Isotope analysis</li><li>Academic</li></ul><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_FLASH_2000_CHNS_O_Analyzers_3139f1b44b.jpg" alt="Thermo Scientific™ FLASH 2000 CHNS/O Analyzers" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_FLASH_2000_CHNS_O_Analyzers_3139f1b44b.jpg 149w," sizes="100vw" width="650" height="680"><h3>Gain Cost Efficiency and Improve Productivity</h3>The simplicity of the OEA method combined with unparalleled data reproducibility and truly quantitative results are the essence of the sophisticated package of benefits offered by the FLASH 2000 Series OEA instruments.<ul><li>Wide analytical range, enabling extensive applications</li><li>Versatility and modularity, ensuring that performance meets users' requirements no matter how often those requirements change</li><li>Accuracy and precision due to the integrated mass flow controller, which enables high stability to deliver precise, accurate results in all sample types and concentrations</li><li>Ease of use as a result of the unique automated functions, reducing the demands on operators</li><li>Simplified operation with Thermo Scientific™ Eager Xperience™ software, which minimizes user involvement in set-up</li><li>Compatibility and automation no matter how high your throughput requirement, with a range of autosamplers that ensures efficient analysis</li><li>Comprehensive and user-friendly software, a useful and powerful tool tailored for every lab requirement</li><li>Ground-breaking OEA CookBook (4th edition), which provides a wealth of analysis tips to get optimal results every time</li></ul></div></div>

Thermo Scientific™ FLASH 2000 N/Protein Analyzers

The FLASH 2000 N/Protein analyzer delivers accurate nitrogen and protein determination in all foods and beverages, operating 24/7 with both solid and liquid samples.

<div><div><h4>Determine Nitrogen concentration and the relative protein content in every type of food and beverage.</h4>The Thermo Scientific™ FLASH 2000 N/Protein analyzer is an essential tool for both Quality Control and Research/Development laboratories in the food industry, which require precise and accurate determinations, limited cost per analysis, and a 24 hour hard worker able to analyze solid and liquid samples continuously.Providing a reliable, high-speed, accurate 24/7 analytical solution to a range of industries, this series of flexible, configurable analyzers uses a globally recognized technique endorsed by official organizations worldwide.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_FLASH_2000_CHNS_O_Analyzers_3139f1b44b.jpg" alt="Thermo Scientific™ FLASH 2000 N/Protein Analyzers" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_FLASH_2000_CHNS_O_Analyzers_3139f1b44b.jpg 149w," sizes="100vw" width="650" height="680"><h3>An Elemental Analysis Solution for a Range of Industries</h3>With an extraordinary range of applications, the modular design of the FLASH 2000 Series OEAs enables 12 configurations tailored to the fields of application they serve.<ul><li>Organic or inorganic chemistry and pharmaceuticals</li><li>Petrochemistry and energy</li><li>Environmental analysis</li><li>Material characterization</li><li>Agronomy and marine science</li><li>Food industry</li><li>Human and animal samples</li><li>Isotope analysis</li><li>Academic</li></ul><h3>Gain Cost Efficiency and Improve Productivity</h3>The simplicity of the OEA method combined with unparalleled data reproducibility and truly quantitative results are the essence of the sophisticated package of benefits offered by the FLASH 2000 Series OEA instruments.<ul><li>Wide analytical range, enabling extensive applications</li><li>Versatility and modularity, ensuring that performance meets users' requirements no matter how often those requirements change</li><li>Accuracy and precision due to the integrated mass flow controller, which enables high stability to deliver precise, accurate results in all sample types and concentrations</li><li>Ease of use as a result of the unique automated functions, reducing the demands on operators</li><li>Simplified operation with Thermo Scientific™ Eager Xperience™ software, which minimizes user involvement in set-up</li><li>Compatibility and automation no matter how high your throughput requirement, with a range of autosamplers that ensures efficient analysis</li><li>Comprehensive and user-friendly software, a useful and powerful tool tailored for every lab requirement</li><li>Ground-breaking OEA CookBook (4th edition), which provides a wealth of analysis tips to get optimal results every time</li></ul></div></div>

Thermo Scientific Triton Series Multicollector Thermal Ionization Mass Spectrometer (TIMS)

High-precision multicollector TIMS for demanding isotope ratio analysis, delivering exceptional sensitivity, stability, and accuracy for ultra-small and low-abundance samples.

The Thermo Scientific™ Triton™ Series Multicollector Thermal Ionization Mass Spectrometer (TIMS) is a high-precision platform designed for the most demanding isotope ratio measurements. Built on more than two decades of continuous development, the Triton Series combines field-proven TIMS performance with state-of-the-art detection and ion-optical technologies to deliver exceptional accuracy, stability, and sensitivity—especially for small samples and low-abundance isotopes.At the heart of the Triton Series is a high-stability thermal ionization source, optimized for maximum ion transmission and minimal kinetic energy spread. This ensures highly reproducible ion beams for both single- and double-filament techniques, enabling precise isotope ratio analysis across a wide range of elements and applications.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Triton_Series_Multicollector_Thermal_Ionization_Mass_Spectrometer_TIMS_2_e9fa5e958e.jpg" alt="Thermo Scientific Triton Series Multicollector Thermal Ionization Mass Spectrometer (TIMS)" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Triton_Series_Multicollector_Thermal_Ionization_Mass_Spectrometer_TIMS_2_e9fa5e958e.jpg 182w," sizes="100vw" width="650" height="558"><h3>Advanced detection and ion optics</h3>The Triton Series integrates multiple complementary detector technologies to address diverse analytical challenges:<ul><li>10¹³ Ω Amplifier Technology extends the lower detection limits, delivering faster response times, extremely low noise, and significantly improved internal precision for small ion beams.</li><li>Retarding Potential Quadrupole (RPQ) lenses provide exceptional abundance sensitivity by suppressing scattered ions and mass tailing, enabling accurate quantification of minor isotopes even next to intense ion beams.</li><li>Multi Ion Counting (MIC) packages allow simultaneous detection of the lowest-intensity ion beams using SEM and CDD ion counters, with flexible configurations tailored to nuclear, geochronological, and geochemical applications.</li><li>Stable, linear SEM and CDD ion counters ensure reliable measurements for ultra-low sample amounts and rare isotopes.</li><li>High-performance Faraday cups guarantee uniform response, long operational lifetime, and excellent linearity for high-precision static and dynamic measurements.</li><li>Movable multicollector array supports up to nine Faraday cups with precise alignment over a wide mass range, extendable to static Ca and Li isotope measurements.</li><li>Virtual amplifier technology enables cancellation of gain factor uncertainties through amplifier rotation, achieving low-ppm external reproducibility in efficient static measurement modes.</li></ul><h3>Designed for the most demanding isotope ratio applications</h3>The Triton Series is ideally suited for applications where ultimate precision and high abundance sensitivity are essential, including:<ul><li>Radiogenic and stable isotope geochemistry</li><li>Geochronology (U–Pb, Pb–Pb, Rb–Sr, Sm–Nd, Lu–Hf systems)</li><li>Nuclear safeguards and nuclear forensic isotope analysis</li><li>Environmental and cosmochemical research</li><li>Analysis of ultra-small sample amounts and isotopically scarce materials</li></ul>Available in configurations such as Triton XT and Triton Plus, tailored to different performance priorities within high-precision isotope ratio analysis, the Thermo Scientific Triton Series TIMS offers a flexible, future-proof solution that continues to set the benchmark for thermal ionization mass spectrometry.

Thermo Scientific ConFlo IV Universal Continuous Flow Interface

Universal continuous flow interface for IRMS enabling automated multi-device control, higher throughput, lower costs, and stable, unattended isotope analysis.

Thermo Scientific™ ConFlo IV Universal Continuous Flow Interface is a versatile continuous flow interface designed to significantly expand the application range of stable isotope laboratories using isotope ratio mass spectrometry (IRMS). The ConFlo IV system enables seamless connection of multiple sample preparation devices, delivering fully automated, stable, and highly reproducible measurements.The system features intelligent management of all required reference gases, automatic sample-size recognition, precise matching of sample and reference signals, and advanced self-diagnostics. These capabilities reduce operator involvement, lower operating costs, and increase overall laboratory throughput.<h3>Key features</h3><ul><li>Management of multiple devices Automated switching between different sample preparation units, including activation, deactivation, and reference gas changes, maximizes IRMS utilization.</li><li>Continuous, unattended operation Application switching can occur at any time without operator intervention; preparation devices can be regenerated and reloaded while other analyses are running.</li><li>Maximized performance and efficiency Using reference gases instead of bulk reference materials reduces operating costs by nearly 50 % while increasing sample throughput by almost 50 %.</li><li>Enhanced accuracy and stability Automatic adjustment of reference gas pulse intensities equalizes conditions between sample and reference gases, improving precision and long-term reliability.</li><li>Advanced data quality control Critical system parameters affecting data quality are automatically monitored across all sample sequences.</li><li>Single-interface control All connected preparation and inlet devices are controlled through one interface, with the ability to add new samples or entirely new applications without interrupting ongoing data acquisition.</li></ul>

Thermo Scientific DELTA Q Isotope Ratio Mass Spectrometer

High-performance IRMS combining exceptional sensitivity, robust design, and intuitive Qtegra ISDS software for food authenticity, environmental, forensic, and research isotope applications.

The Thermo Scientific™ DELTA™ Q Isotope Ratio Mass Spectrometer (IRMS) represents a new evolutionary step in isotope ratio analysis, combining outstanding analytical performance with intuitive operation powered by <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/products/1489">Qtegra™ Intelligent Scientific Data Solution (ISDS)</a> software.&nbsp;The DELTA Q IRMS is designed for seamless integration with a wide range of Thermo Scientific peripherals, making it a highly flexible platform for applications such as food authenticity testing, environmental and forensic analysis, doping control, and advanced scientific research.<h4>Outstanding sensitivity</h4><ul><li>Sensitivities of up to 800 molecules per CO₂ ion in dual-inlet mode and 1,000 molecules per ion in continuous-flow mode.</li></ul><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_DELTA_Q_Isotope_Ratio_Mass_Spectrometer_2_671e47510f.jpg" alt="Thermo Scientific DELTA Q Isotope Ratio Mass Spectrometer" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_DELTA_Q_Isotope_Ratio_Mass_Spectrometer_2_671e47510f.jpg 197w," sizes="100vw" width="650" height="517"><h4>Versatility for diverse applications</h4><ul><li>Support for up to 10 collectors in multiple configurations, covering all IRMS applications up to m/z 96.</li><li>Simultaneous mass range up to ±25%, enabling efficient multi-isotope measurements.</li><li>Compatibility with preconcentrators, elemental analyzers, GC interfaces, LC interfaces, and continuous-flow inlets.</li><li>On-line H₂ capability for hydrogen isotope analysis.</li></ul><h4>Highly robust and reliable design</h4><ul><li>A monolithic analyzer with fixed alignment of all ion-optical components, including the electromagnet, ensuring exceptional long-term stability and robustness.</li><li>Integrated signal amplifiers and digitizers minimize external connections and increase reliability.</li><li>Fixed-position ion optics eliminate the need for realignment during installation or routine maintenance.</li><li>Optimized pumping strategy enables single-stage turbo pumping for all standard continuous-flow applications.</li><li>Comprehensive, automated diagnostics driven by Qtegra ISDS software support continuous performance monitoring.</li></ul><h4>Compact and user-friendly design</h4><ul><li>Compact footprint requiring minimal laboratory space.</li><li>Dedicated space for online peripherals on top of the instrument.</li><li>Dual inlet, µ-volume, and multiport interfaces are neatly integrated inside the system.</li><li>Continuous-flow interfaces can be fully controlled from the front panel.</li><li>All pumps are located internally, reducing noise and laboratory clutter.</li></ul><h4>Qtegra™ ISDS Software</h4><ul><li>Significantly increases laboratory productivity with automatic Get Ready functionality, ready-to-use templates, and built-in quality control tools.</li><li>Intelligent, optimized workflows guide users from sample to result while allowing flexible switching between system configurations.</li><li>Ensures full data integrity and traceability for raw data, metadata, and reported results.</li></ul><h4>ACT label certification</h4>The DELTA Q IRMS is certified with the ACT Environmental Impact Label from My Green Lab, providing transparent, third-party verified information on environmental impact across manufacturing, energy and water use, packaging, and end-of-life considerations—supporting sustainable laboratory procurement and reduced carbon footprint.

rHGH fragment or AOD-9604 (LCMS+CHNS) analysis

Combined LC-MS, CHNS and HPLC analysis of rHGH fragment 176–191 and AOD-9604 for identification, amount, peptide purity and contamination screening.

This analysis is designed to identify and determine the amount and purity of recombinant Human Growth Hormone fragment 176–191 and AOD-9604. It combines LC-MS, CHNS and HPLC to provide information about peptide identity, net peptide content, peptide purity and potential contamination with other peptides or degradation products.The test can detect and measure either target compound. It is therefore not necessary to know in advance whether the sample contains rHGH fragment 176–191 or AOD-9604.<h4>rHGH Fragment 176–191</h4>rHGH fragment 176–191, also known as somatropin 176–191, is a peptide corresponding to amino acids 176 to 191 of Human Growth Hormone. It consists of 16 amino acids and represents the C-terminal region of the HGH molecule.Its molecular weight is approximately 1,799 Da. It differs from AOD-9604 in the first amino acid of its sequence.<h4>AOD-9604</h4>AOD-9604 is a synthetically modified peptide derived from Human Growth Hormone fragment 176–191. Like the rHGH fragment, it contains 16 amino acids, but its sequence begins with tyrosine instead of phenylalanine.This structural difference allows the two peptides to be distinguished by LC-MS. The molecular weight of AOD-9604 is approximately 1,815 Da.<h4>Analytical Methods</h4><h5>LC-MS – Identification and Contamination Screening</h5>LC-MS is used to confirm the identity of the peptide in the sample. It also provides screening for detectable contamination with other peptides and peptide degradation products.<h5>CHNS – Net Peptide Content Determination</h5>CHNS elemental analysis measures the carbon, hydrogen, nitrogen and sulphur content of the sample. The measured values can be used to determine Net Peptide Content.Because the sample is combusted during CHNS analysis, the result is not affected by solubility issues that may complicate chromatographic measurement of peptide amount.<h5>HPLC – Peptide Purity Determination</h5>HPLC is used to determine peptide purity and the relative proportion of the main peptide component compared with chromatographically detectable impurities.<h4>What the Analysis Determines</h4><ul><li>Identity of rHGH fragment 176–191 or AOD-9604</li><li>Amount of peptide in the sample</li><li>Net peptide content determined by CHNS</li><li>Peptide purity determined by HPLC</li><li>Presence of other peptides or degradation products detected by LC-MS</li><li>Differentiation between rHGH fragment 176–191 and AOD-9604</li></ul><h4>Analysis Parameters</h4><ul><li>Target compounds: rHGH fragment – somatropin 176–191 and AOD-9604</li><li>CAS number of AOD-9604: 221231-10-3</li><li>Molecular weight of AOD-9604: 1,815 Da</li><li>AOD-9604 sequence: H-Tyr-Leu-Arg-Ile-Val-Gln-Cys(1)-Arg-Ser-Val-Glu-Gly-Ser-Cys(1)-Gly-Phe-OH</li><li>CAS number of rHGH fragment: 66004-57-7</li><li>Molecular weight of rHGH fragment: 1,799 Da</li><li>rHGH fragment sequence: H-Phe-Leu-Arg-Ile-Val-Gln-Cys(1)-Arg-Ser-Val-Glu-Gly-Ser-Cys(1)-Gly-Phe-OH</li><li>Identification method: LC-MS</li><li>Amount determination method: CHNS</li><li>Peptide purity method: HPLC</li><li>Detection limit: less than one twentieth of the usual dosage per vial</li><li>Result format for lyophilizates: mg per vial and peptide purity</li><li>Alternative result format: m/m purity and peptide purity</li><li>Minimum lyophilizate sample: one whole unopened vial containing the lyophilizate</li><li>Minimum raw API powder sample: 30 mg in a sealed glass vial to prevent moisture absorption</li><li>Average turnaround time: 7 business days</li></ul><blockquote><h5>Important Notice</h5>The alternative m/m purity result format is intended exclusively for raw API powders. For lyophilized samples, the standard result format provides the peptide amount in mg per vial together with peptide purity.</blockquote><h4>Additional Analyses</h4><h5>TFA Analysis</h5><ul><li>Detection and measurement of trifluoroacetic acid (TFA) in the sample. Results are reported in mg per vial.</li></ul><h5>Raw Data</h5><ul><li>Delivery of the available raw analytical data from the primary test and all applicable additional analyses.</li></ul><h5>Fentanyl Presence Analysis</h5><h5>Alternative Result Format – m/m Purity</h5><ul><li>Alternative reporting of the result as mass-by-mass purity. This option is intended exclusively for raw API powders.</li></ul><h5>Variance Testing</h5><ul><li>Analysis of multiple sample units to assess variation within a single batch. All submitted samples must originate from the same batch of the same product.</li></ul><h5>pH Measurement</h5><h5>Endotoxin Analysis</h5><ul><li>Measurement of bacterial endotoxins, particularly lipopolysaccharides (LPS), in the sample. This analysis is available only for finished products and should not be ordered for raw powders.</li><li>The standard test provides accurate results up to 10 EU per vial. Values above 10 EU per vial are estimated and require an additional test with a different dilution for precise determination. Sending two vials is therefore recommended.</li><li>Where endotoxin levels above 10 EU per vial are expected, the method can be calibrated for the higher range in advance.</li></ul><h5>Additional Report</h5><ul><li>A separate additional laboratory report issued under a different client name.</li></ul><h5>Sterility Testing</h5><ul><li>TAMC and TYMC testing checks the product for the presence of bacteria, yeasts and moulds. Additional unopened sample units must be submitted for analysis. The average turnaround time for this test is 14 days.</li></ul><h5>Heavy Metals Analysis</h5><ul><li>Detection of arsenic, cadmium, lead and mercury in the sample. Testing for other metals can be arranged individually.</li></ul>

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