Structure-guided libraries and machine learning enable faster discovery of active nucleic acid sequences beyond random mutagenesis.

This study introduces a biochemometric 2D NMR heterocovariance approach to correlate spectral features with bioactivity, enabling targeted discovery of bioactive compounds in complex extracts.

This study combines metabolomics, structural analysis, and public omics data to uncover the extensive diversity and global distribution of kurstakin lipopeptides linked to Bacillus biocontrol activity.

This study investigates the synthesis and curing of a furan-based glycidyl amine epoxy resin, revealing improved stiffness and Tg through α-chlorohydrin-driven cross-link formation.

This study shows that black soldier fly larvae ingest mainly small microplastics during waste bioconversion, with no bioaccumulation and over 90% elimination after short starvation.

A coumarin-based photocleavable solid support allows visible-light release and nonchromatographic purification of RNA oligonucleotides, including UV-sensitive phosphorothioate backbones.

A portable graphene-based single-atom membrane enables one-step removal of bacteria and heavy metals using a hand-powered vacuum, achieving high efficiency and reusability for off-grid water treatment.

Alcohol consumption produces acetaldehyde, a toxic compound that damages DNA. Scientists from IOCB Prague reveal how cells repair this damage, shedding light on the link between alcohol and cancer.

Long-term administration of proton pump inhibitors affected mineral bioavailability and blood parameters in rats, suggesting risks of iron, calcium, and copper deficiency.

IOCB Prague is co-founding Taveren Therapeutics, a new biotech spin-off developing a novel cancer treatment strategy based on reactivating the body’s natural tumor suppressors.