<h4><strong>Overcoming matrix suppression and signal drift in environmental samples and industrial brines</strong></h4><p>As demand for lithium, rare earth elements (REEs), and environmental monitoring continues to grow, laboratories are increasingly challenged by one of the most difficult sample types in elemental analysis: high-salinity waters. Whether analyzing lithium-rich underground brines for electric vehicle battery production or monitoring seawater and brackish water for environmental compliance, laboratories require a solution that combines sensitivity, robustness, and productivity.</p><p>The <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/products/1487"><strong>Thermo Scientific iCAP MSX ICP-MS</strong></a> addresses these challenges by delivering reliable trace element analysis across a wide range of salt concentrations—from seawater to highly concentrated brines containing up to 25% sodium chloride.</p><h3><strong>Why high-salt samples challenge ICP-MS</strong></h3><p>Brines and seawater present significant analytical obstacles.<strong> High dissolved solids can cause:</strong></p><ul><li>Signal drift and matrix suppression</li><li>Nebulizer blockages</li><li>Torch injector fouling</li><li>Interface cone contamination</li><li>Increased maintenance and downtime</li></ul><p>Traditional workflows often require extensive manual dilution, frequent recalibration, and additional operator intervention. These steps reduce throughput and increase operating costs.</p><h3><strong>A unified solution for brines and seawater</strong></h3><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Fisher_Scientific_Trace_Metal_Analysis_in_High_Salt_Matrices_by_ICP_MS_4_78a4a8997a.jpg" alt="Thermo Fisher Scientific: Trace Metal Analysis in High Salt Matrices by ICP-MS" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Fisher_Scientific_Trace_Metal_Analysis_in_High_Salt_Matrices_by_ICP_MS_4_78a4a8997a.jpg 245w," sizes="100vw" width="1808" height="900"></p><p>The<strong> iCAP MSX ICP-MS</strong> leverages integrated <strong>Argon Gas Dilution (AGD) technology</strong> to enable direct analysis of challenging high-matrix samples while maintaining excellent sensitivity and stability.</p><p><strong>Key advantages include:</strong></p><ul><li>Analysis of brines up to <strong>25% NaCl </strong>without manual dilution</li><li>High matrix tolerance with the AGD High setting</li><li>Automated tuning and instrument health monitoring</li><li>Stable internal standard performance</li><li>Reduced maintenance requirements</li><li>Consistent data quality across varying salt concentrations</li><li>Reduced sample handling, dilution apparatus, and potential for contamination</li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Fisher_Scientific_Trace_Metal_Analysis_in_High_Salt_Matrices_by_ICP_MS_3_785f2e2d29.jpg" alt="Thermo Fisher Scientific: Trace Metal Analysis in High Salt Matrices by ICP-MS" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Fisher_Scientific_Trace_Metal_Analysis_in_High_Salt_Matrices_by_ICP_MS_3_785f2e2d29.jpg 221w," sizes="100vw" width="1400" height="989"></p><p>This unified approach allows laboratories to use a <strong>single method for multiple sample types</strong>, improving efficiency and simplifying operations.</p><h3><strong>Engineered for robustness</strong></h3><p><strong>Several hardware innovations contribute to the system’s performance:</strong></p><p><strong>Collision / Reaction Cell</strong><br>The Thermo Scientific QCell Collision / Reaction Cell utilizes a proprietary Flatapole design and integrated low-mass cutoff technology to provide effective interference removal while maintaining high ion transmission and sensitivity.</p><p><strong>RAPID lens technology</strong><br>The Right Angle Positive Ion Deflection (RAPID) lens system uses a fully focused 90-degree ion deflection design that helps keep the mass spectrometer maintenance-free after the interface region.</p><p><strong>Flexible AGD operation</strong><br>Unlike alternative matrix-handling approaches, AGD offers selectable dilution levels fully integrated within the <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/products/1489"><strong>Thermo Scientific Qtegra Intelligent Scientific Data Solution (ISDS) software</strong></a>, simplifying operation while maintaining performance.</p><h3><strong>Supporting the growing lithium and rare earth economy</strong></h3><p>The rapid expansion of electric vehicle production has intensified the need for reliable impurity analysis in lithium-rich underground brines. Accurate determination of trace metals and rare earth elements is essential for:</p><ul><li>Resource characterization</li><li>Process optimization</li><li>Product quality assurance</li><li>Regulatory compliance</li></ul><p>The ability to analyze both concentrated brines and seawater using a single workflow enables laboratories to support upstream extraction, refining operations, and environmental monitoring with greater efficiency.</p><h3><strong>Improving productivity through intelligent automation</strong></h3><p>Beyond analytical performance, the<strong> iCAP MSX ICP-MS</strong> is designed to reduce the operator’s workload through:</p><ul><li>Automatic instrument tuning</li><li>Integrated health monitoring</li><li>Hawk Consumables and Maintenance Assistant</li><li>Simplified maintenance planning</li><li>Reduced risk of unplanned downtime</li></ul><p>These features help laboratories maximize instrument uptime while maintaining confidence in data quality.</p><h3><strong>Seawater validation data demonstrates excellent accuracy and sensitivity</strong></h3><p>To evaluate analytical performance in a challenging marine matrix, seawater samples were analyzed both unspiked and with trace-element spike additions of <strong>1 ppb and 0.1 ppb</strong>. The study included transition metals, precious metals, and Rare Earth Elements (REEs) measured using KED mode.</p><h5><strong>1 ppb spike recovery results</strong></h5><p>The 1 ppb spike experiment demonstrated strong recoveries across most analytes:</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Fisher_Scientific_Trace_Metal_Analysis_in_High_Salt_Matrices_by_ICP_MS_c27a27a631.jpg" alt="Thermo Fisher Scientific: Trace Metal Analysis in High Salt Matrices by ICP-MS" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Fisher_Scientific_Trace_Metal_Analysis_in_High_Salt_Matrices_by_ICP_MS_c27a27a631.jpg 110w," sizes="100vw" width="834" height="1180"></p><p>The majority of REEs showed recoveries between approximately <strong>102% and 116%</strong>, demonstrating excellent accuracy in a high-salt seawater matrix. Particularly noteworthy were <strong>Er (115.6%), Dy (114.9%), Yb (114.0%), and Gd (114.0%)</strong>, highlighting the capability of the system for strategic element monitoring.</p><h5><strong>0.1 ppb spike recovery results</strong></h5><p>Performance remained strong at ten-fold lower concentration levels:</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Fisher_Scientific_Trace_Metal_Analysis_in_High_Salt_Matrices_by_ICP_MS_2_d045eb8be8.jpg" alt="Thermo Fisher Scientific: Trace Metal Analysis in High Salt Matrices by ICP-MS" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Fisher_Scientific_Trace_Metal_Analysis_in_High_Salt_Matrices_by_ICP_MS_2_d045eb8be8.jpg 115w," sizes="100vw" width="834" height="1129"></p><p>These results demonstrate reliable quantification at sub-ppb concentrations, supporting environmental monitoring and trace impurity applications where ultra-low detection capability is essential.</p><h3><strong>What does this mean for laboratories?</strong></h3><p>The seawater data confirms that the iCAP MSX ICP-MS can deliver:</p><ul><li>Accurate recovery of trace metals and rare earth elements</li><li>Reliable measurements at low and sub-ppb concentrations</li><li>Excellent sensitivity across a broad elemental range</li><li>Robust operation in challenging high-salt matrices</li><li>A single workflow applicable for seawater, brackish water, and concentrated brines</li></ul><p>For laboratories supporting lithium extraction, critical minerals programs, environmental monitoring, or industrial process control, these capabilities translate directly into higher confidence in analytical results and increased operational efficiency.</p><h3><strong>Conclusion</strong></h3><p>As industries increasingly rely on accurate elemental analysis of high-salinity samples, laboratories need instrumentation capable of balancing sensitivity, robustness, and productivity. The<a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/products/1487"><strong> iCAP MSX ICP-MS </strong></a>provides a comprehensive solution for both industrial brine applications and environmental seawater monitoring, delivering accurate recoveries, low detection limits, and reliable performance across some of the most challenging matrices encountered in ICP-MS analysis.</p><p>From lithium extraction to environmental stewardship, the future of trace element analysis depends on technologies that can turn difficult samples into dependable data.</p><blockquote><p>Register for our on-demand webinar to learn more about the iCAP MX Series ICP-MS <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/webinar/6398"><strong>New ICP-MS innovations to ignite productivity and efficiency in your laboratory</strong></a></p></blockquote><ul><li><strong>Visit us on&nbsp;</strong><a target="_blank" rel="noopener noreferrer" href="https://www.linkedin.com/showcase/72003132/admin/dashboard/"><strong><u>LinkedIn:</u></strong></a>&nbsp;#ICPMS #EnvironmentalTesting #REEs #ElementalAnalysis</li></ul>

Trace Metal Analysis in High Salt Matrices by ICP-MS

<p><strong>Colourful vortices, loops and currents resembling magnetic storms or abstract digital art. This is what maps of magnetically induced electron currents look like, created by an international team including chemists from CEITEC Masaryk University while studying molecules containing gold, mercury and the rare element astatine.</strong></p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/CEITEC_Chemici_z_CEITEC_zachytili_elektronove_boure_ve_zlate_a_rtuti_4_7b12d14b21.jpeg" alt="CEITEC: CEITEC Chemists Capture Electron Storms in Gold and Mercury" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_CEITEC_Chemici_z_CEITEC_zachytili_elektronove_boure_ve_zlate_a_rtuti_4_7b12d14b21.jpeg 245w," sizes="100vw" width="1600" height="834"></p><p>What may at first glance resemble visualisations of outer space or ocean currents is in fact taking place inside molecules themselves. Here, electrons form complex currents and vortices whose shapes vary depending on the <strong>type of atom and the nature of the chemical bond.</strong></p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/CEITEC_Chemici_z_CEITEC_zachytili_elektronove_boure_ve_zlate_a_rtuti_3_9e2f79434f.jpeg" alt="CEITEC: CEITEC Chemists Capture Electron Storms in Gold and Mercury" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_CEITEC_Chemici_z_CEITEC_zachytili_elektronove_boure_ve_zlate_a_rtuti_3_9e2f79434f.jpeg 245w," sizes="100vw" width="1600" height="834"></p><p>And this is where Einstein enters the picture. In heavy elements, electrons move so rapidly that their behaviour is influenced by the effects of special relativity. Without relativistic physics, some of these remarkable electron patterns would not exist at all.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/CEITEC_Chemici_z_CEITEC_zachytili_elektronove_boure_ve_zlate_a_rtuti_8_5fc3a0ed98.jpeg" alt="CEITEC: CEITEC Chemists Capture Electron Storms in Gold and Mercury" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_CEITEC_Chemici_z_CEITEC_zachytili_elektronove_boure_ve_zlate_a_rtuti_8_5fc3a0ed98.jpeg 245w," sizes="100vw" width="1600" height="827"></p><p>While some atoms are surrounded by almost perfectly symmetrical current flows, others generate distorted vortices or local turbulences resembling miniature electron storms. Using <strong>advanced computational methods</strong>, the researchers were able to capture these differences in unprecedented detail.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/CEITEC_Chemici_z_CEITEC_zachytili_elektronove_boure_ve_zlate_a_rtuti_5_0e0f36c76a.jpeg" alt="CEITEC: CEITEC Chemists Capture Electron Storms in Gold and Mercury" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_CEITEC_Chemici_z_CEITEC_zachytili_elektronove_boure_ve_zlate_a_rtuti_5_0e0f36c76a.jpeg 245w," sizes="100vw" width="1600" height="834"></p><p>The results provide not only new insights into the behaviour of heavy elements but also a visually fascinating glimpse into a world that normally remains hidden from human eyes.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/CEITEC_Chemici_z_CEITEC_zachytili_elektronove_boure_ve_zlate_a_rtuti_7_462defafce.jpeg" alt="CEITEC: CEITEC Chemists Capture Electron Storms in Gold and Mercury" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_CEITEC_Chemici_z_CEITEC_zachytili_elektronove_boure_ve_zlate_a_rtuti_7_462defafce.jpeg 245w," sizes="100vw" width="1600" height="834"></p><p>Scientists study such phenomena because the behaviour of electrons determines how stable molecules are, how they react, and what properties they possess. In heavy elements, however, the rules of classical chemistry often reach their limits – and relativity comes into play.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/CEITEC_Chemici_z_CEITEC_zachytili_elektronove_boure_ve_zlate_a_rtuti_01832dca81.jpeg" alt="CEITEC: CEITEC Chemists Capture Electron Storms in Gold and Mercury" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_CEITEC_Chemici_z_CEITEC_zachytili_elektronove_boure_ve_zlate_a_rtuti_01832dca81.jpeg 245w," sizes="100vw" width="1600" height="834"></p><p>A better understanding of these effects could eventually contribute to the design of new catalysts or materials based on heavy metals. For the researchers themselves, studying such electron structures is also a way of exploring one of the least intuitive realms of modern chemistry.</p><p>The study was published in <a target="_blank" rel="noopener noreferrer" href="https://doi.org/10.1021/jacsau.6c00346"><strong>JACS Au</strong></a>.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/CEITEC_Chemici_z_CEITEC_zachytili_elektronove_boure_ve_zlate_a_rtuti_6_a2a8433b8b.jpeg" alt="CEITEC: CEITEC Chemists Capture Electron Storms in Gold and Mercury" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_CEITEC_Chemici_z_CEITEC_zachytili_elektronove_boure_ve_zlate_a_rtuti_6_a2a8433b8b.jpeg 245w," sizes="100vw" width="1600" height="834"></p><blockquote><h4><strong>Original article</strong></h4><h4><a target="_blank" rel="noopener noreferrer" href="https://pubs.acs.org/doi/10.1021/jacsau.6c00346"><span><strong>Link between Spin–Orbit Relativity and Magnetically Induced Current Densities in Heavy-Atom Hydrides: </strong></span><i><span><strong>trans</strong></span></i><span><strong>-Ligand Influence</strong></span></a></h4><p>Daniel Blasco, Jan Novotný, James R. Asher, Raphael J. F. Berger, Stanislav Komorovsky, Radek Marek</p><p><i><span><strong>JACS Au</strong></span></i><strong> </strong><span>2026, 6, 6, 3323–3335</span></p><p><a target="_blank" rel="noopener noreferrer" href="https://doi.org/10.1021/jacsau.6c00346">https://doi.org/10.1021/jacsau.6c00346</a></p><h6>licensed under <a target="_blank" rel="noopener noreferrer" href="https://creativecommons.org/licenses/by/4.0/">CC-BY 4.0&nbsp;</a></h6></blockquote><h4><strong>Abstract</strong></h4><p>Interactions between individual atoms underpin the structure and behavior of matter. These interactions govern atomic positions and dynamics, as well as the organization of electrons─particularly in the frontier region. Because electrons lie at the core of chemical phenomena, numerous theoretical frameworks have been developed to rationalize the molecular structure and properties. Electronic motion within molecules and the resulting induced currents provide powerful probes of the molecular or supramolecular structure, building on and going beyond molecular orbital and valence bond theories. In particular, current density offers a spatially-resolved description of the electronic response to external perturbations, enabling direct analysis of electron delocalization and magnetic response in molecular systems. In this work, the effect of relativistic spin–orbit (SO) coupling on the strength and topology of the magnetically induced current density (MICD) is analyzed in depth for a series of model heavy-atom hydrides at the four-component Dirac-Kohn–Sham level. For the most simple molecules, TlH, HAt, and AuH, we demonstrate a connection between the SO effects on the molecular geometry, strength and topology of MICDs, and ligand <sup>1</sup>H NMR shielding. For model <strong>HMX</strong> molecules, where M = Au<sup>I</sup>, Hg<sup>II</sup>; X = F, Cl, Ph, CH<sub>3</sub>, H, SiH<sub>3</sub>, BH<sub>2</sub>, the hydride deshielding due to the slight elongation of the M–H bond upon increasing the <i>trans</i>-ligand influence (TLI) of X is shown to be marginal when compared to that originating from the electronic SO effect. In particular, the inclusion of SO effects gives rise to highly localized paratropic MICD vortices on the hydride position of those complexes bearing strong TLI ligands. Our results disprove the previously proposed governing role of the current around the metal atom (similar to the classical Buckingham-Stephens model for transition metal hydrides) associated with TLI-induced variations in the metal–hydrogen bond length in determining the characteristic ligand <sup>1</sup>H NMR shifts.</p>

CEITEC Chemists Capture Electron Storms in Gold and Mercury 

<p><strong>Our Library never stops expanding. What are the most recent contributions to LabRulezICPMS Library in the week of 20th July 2026? Check out new documents from the field of spectroscopy/spectrometry and related techniques!</strong></p><blockquote><p><span style="font-size:20px;">👉 </span><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/library"><span style="font-size:20px;"><strong>SEARCH THE LARGEST REPOSITORY OF DOCUMENTS ABOUT SPECTROSCOPY/SPECTROMETRY RELATED TECHNIQUES</strong></span></a></p></blockquote><blockquote><p><strong>👉 Need info about different analytical techniques?</strong> Peek into <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/library"><strong>LabRulezLCMS</strong></a> or <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library"><strong>LabRulezGCMS</strong></a> libraries.</p></blockquote><p>This week we bring you application notes by <strong>Agilent Technologies,</strong> <strong>Shimadzu </strong>and <strong>Thermo Fisher Scientific!</strong></p><h3><strong>1. Agilent Technologies: Analysis of Elemental Impurities in GLP-1 Receptor Agonist Oral Tablets by ICP-MS</strong></h3><ul><li>Application note</li><li><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/labrulez-bucket-strapi-h3hsga3/an_glp_1_receptor_tablets_7850_icp_ms_5994_9317en_agilent_c355750808.pdf"><strong>Full PDF for download</strong></a><strong>&nbsp;</strong></li></ul><p>Glucagon-like peptide-1 (GLP-1) receptor agonists represent a rapidly expanding class of therapeutics for the management of type 2 diabetes and chronic weight management. While many approved GLP-1 receptor agonists are administered by subcutaneous injections, oral formulations are generating significant clinical and commercial interest. However, formulating peptide-based therapeutics as oral solid dosage forms introduces additional manufacturing complexity, including the need for permeation enhancers, excipients, and coating materials. Each of these components presents a potential source of elemental impurity contamination. International or national-based regulatory authorities are responsible for ensuring that pharmaceutical products are both effective and safe for use. Control of elemental impurities in drug products is governed by the International Council for Harmonisation (ICH) Guideline for Elemental Impurities, Revision 2 (Q3D(R2))<sup>1</sup> and United States Pharmacopeia (USP) &lt;232&gt;/&lt;233&gt; (Elemental Impurities — Limits and Procedures)<sup>2,3</sup> using ICP-OES- or ICP-MS-based instrumental methods.</p><p>The USP chapters classify 24 elemental impurities in three classes based on toxicity and probability of occurrence, with permitted daily exposure (PDE) limits defined by route of administration. Analytical method validation follows ICH Q2(R2) (Validation of Analytical Procedures, 2023)<sup>4</sup> and the harmonized USP &lt;1225&gt; (Validation of Compendial Procedures)<sup>5</sup> , with system suitability criteria defined in USP &lt;233&gt;.<sup>3</sup> ICH Q2(R2) provides updated guidance on the validation of analytical procedures that is applicable to biological- and biotechnology-derived products. The revised guideline offers clearer guidance on complex therapeutics, such as peptide-based biotherapeutics, including GLP-1 receptor agonists—an area not specifically addressed in the earlier Q2(R1) framework.&nbsp;</p><p>In this study, an analytical method was developed and validated in accordance with USP &lt;232&gt;/&lt;233&gt; and ICH Q3D(R2)/Q2(R2). The method enables quantitative determination of all 24 regulated elemental impurities in an oral tablet of a GLP-1 receptor agonist using an <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/library?mainauthorItems=10&amp;search=7850"><strong>Agilent 7850 ICP-MS</strong></a><strong>.</strong> The instrument features an integrated fourthgeneration Octopole Reaction System (ORS<sup>4</sup>) collision cell, which was operated in helium (He) mode to provide robust suppression of matrix-derived polyatomic interferences affecting the analytes. Data were acquired to evaluate drift/ stability, detectability, precision (repeatability and intermediate precision), specificity, accuracy, and linearity. </p><h4><strong>Results and discussion&nbsp;</strong></h4><p>Before being used for limit or quantitative procedures, the analytical instrument and method must meet performance criteria defined in ICH Q2(R2) and USP &lt;233&gt;. System suitability—verified by confirming that results remain stable (drift ≤ 20%) throughout the analytical run—must be demonstrated on the day of analysis. Separately, USP &lt;233&gt; requires procedure validation to demonstrate fitness for purpose: detectability, precision, and specificity for Limit Procedures; and accuracy, precision/repeatability, intermediate precision (ruggedness), specificity, limit of quantitation, linearity and range (demonstrated across 0.5–1.5 J) for Quantitative Procedures.</p><h4><strong>Speciation considerations for As and Hg&nbsp;</strong></h4><p>For some elements, toxicity is highly dependent on their chemical form. Of the analytes listed in the ICH/USP regulations, As and Hg are of particular concern. The PDE limit for both elements refers to their inorganic forms because inorganic As is the most toxic, and inorganic Hg is considered the most likely form to be present in pharmaceutical materials.&nbsp;</p><p>If the measured total As concentration exceeds the target concentration, USP &lt;232&gt; suggests that a speciation analysis is performed using LC-ICP-MS to allow independent quantification of inorganic As. If inorganic As is found to be below the limit, the material would be considered compliant even if total As exceeds the limit. The speciation of Hg should be established if the test material is likely to contain the more toxic methyl Hg species (for example, ingredients sourced from marine-derived materials). Otherwise, compliance is established by determining total Hg.&nbsp;</p><p>In this study, only trace-level Li (0.23 ppb) and Ni (0.07 ppb) were detected in the sample blank. All other elements were below the IDLs. Therefore, speciation analysis on As and Hg was not required. However, the 7850 ICP-MS can be easily integrated with an Agilent LC system for routine speciation analysis if needed.<sup>7</sup></p><h4><strong>Conclusion&nbsp;</strong></h4><p>This study demonstrates the suitability of the Agilent 7850 ICP-MS for the identification and quantification of 24 regulated elemental impurities in a GLP-1 receptor agonist oral tablet formulation, prepared by microwave digestion. The instrument’s ORS4 collision cell was operated in helium mode, providing robust, non-specific attenuation of matrixderived polyatomic interferences. The method successfully met the limit and accuracy requirements specified in USP &lt;232&gt;/&lt;233&gt; and ICH Q3D(R2)/Q2(R2) guidelines, ensuring reliable multi-element quantification of GLP-1 tablets without the need for element-specific method optimization. F</p><p>or pharmaceutical QC laboratories, the Agilent ICP-MS MassHunter instrument control software assisted in developing the workflow, reducing the time and effort required to establish a compliant analytical method. The preset ICH/USP method template, automated J-value calculation, and built-in system suitability reporting eliminated manual configuration steps, making it easier for different analysts to use the instrument. The software also enables method transfer across sites. The demonstrated eight-hour signal stability performance of the 7850 ICP-MS further supports high-throughput batch testing in routine manufacturing QC environments.&nbsp;</p><p>As ICH Q2(R2) provides improved clarity for validating analytical procedures used with peptide based therapeutics, including GLP 1 receptor agonists, this application note provides a regulation-ready reference method. The workflow can be directly adopted or adapted for oral solid dosage forms containing active peptide ingredients, supporting faster regulatory submissions and reducing analytical development timelines.</p><h3><strong>2. Shimadzu: State Analysis of Iron Oxides in Sintered Ore for Steel Manufacturing after Hydrogen Reduction</strong></h3><ul><li>Application note</li><li><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/labrulez-bucket-strapi-h3hsga3/an_01_01029_en_ca7771b317.pdf"><strong>Full PDF for download</strong></a></li></ul><h5><strong>User Benefits</strong></h5><ul><li>The mineral structure of sintered ore can be investigated by quantitative mapping of Al, Mg, Si, Ca, and Fe.&nbsp;</li><li>EPMA analysis is a useful technique in research on the composition of the calcium ferrite phase due to differences in the reduction reaction depending on the furnace temperature.&nbsp;</li><li>Investigation of the oxidation state of iron is useful in study of the production conditions for sintered ore, such as oxidation and reduction.</li></ul><p>Foreign matter in CMP* slurrReduction of carbon dioxide (CO2) emissions is being promoted with the aim of achieving carbon neutrality in 2050. In the hydrogen reduction ironmaking process, iron ore is reduced with hydrogen (H2) in place of coke (C), forming water (H2O) instead of CO2, thereby reducing CO2 emissions. Targeting a reduction of 10 % or more in CO2 emissions, research on a hydrogen reduction technology using hydrogen in the blast furnace is now underway in the Japanese national project COURSE50, focusing on reduction of the heat requirement and optimization of the reaction conditions of the raw materials, together with circulating use of gas with a regenerated reduction capacity, by promoting hydrogen reduction, which is a smaller endothermic reaction than direct reduction by coke. Development of a Super COURSE50 technology has also begun, and will make it possible to inject a larger amount of hydrogen into the blast furnace. This article introduces a state analysis of the iron oxides in sintered ore, which was carried out by measuring the detailed spectra of micro-regions in sintered iron ore after hydrogen reduction using an EPMA electron probe microanalyzer (<strong>EPMA8050G</strong>).</p><h4><strong>Phase Analysis of Sintered Ore after Hydrogen Reduction</strong></h4><p>To identify differences in the oxidation valence, the element distribution images in Fig. 3 show oxygen (O) and iron (Fe) by the mass percentage concentration (wt%) of the simple elements. Fig. 4 (a) and (c) are Fe-O scatter diagrams showing the positions of the compounds by the theoretical concentration of iron oxide under low temperature and high temperature reduction, respectively. In Fig. 4 (a), the symbols 〇 and ▼ represent hematite (Fe2O3) and magnetite (Fe3O4), respectively, while in Fig. 4 (c), clusters (point-sets) can be seen in regions showing ☒ wustite (FeO) and compounds of iron (Fe). Fig. 4 (b) and (d) are phase diagrams in which filters were set by the Fe-O scatter diagrams (see Related Applications 3). In the phase diagrams, the purple regions are hematite, red regions are magnetite, green regions are wustite, dark blue regions are iron, yellow regions are magnesia ferrite, blue regions are calcium ferrite, and yellowgreen regions are slag. The sintered ore contains hematite and magnetite before reduction, but in the reduction reactions at the different furnace temperatures, the species of iron oxides are different depending on the furnace temperature. From the element distribution images and phase diagrams, it can be understood that metallic iron (Fe) has formed in the sintered ore subjected to hydrogen reduction at the high temperature of 1000 ˚C. The light blue region in Fig. 4 (d) is considered to be slag.</p><h4><strong>Conclusion</strong></h4><p>Quantitative mapping analysis and phase analysis of sintered ores after hydrogen reduction can be used not only in identification of iron oxide species and calcium ferrite, but also in structural analysis and research and development of the reduction process by utilizing state analysis from the detailed spectra of micro-regions.&nbsp;</p><h3><strong>3. Thermo Fisher Scientific: Accurate analysis of major components and trace level impurities in cathode active materials used in lithium ion battery production</strong></h3><ul><li>Application note</li><li><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/labrulez-bucket-strapi-h3hsga3/an_003968_analysis_impurities_cathode_active_materials_lithium_ion_battery_production_an003968_na_en_97783566af.pdf"><strong>Full PDF for download</strong></a></li></ul><p>Lithium-ion batteries (LIBs) provide a compact and versatile solution for energy storage, powering everything from consumer electronics to electric vehicles (EVs) and large-scale energy systems. Currently, they are the most important power storage materials for EVs due to their power density and life cycle performance. The performance, longevity, and safety of a battery heavily depends on the purity and the composition of the components, especially the cathode material.&nbsp;</p><p>To meet the required performance criteria (i.e., long battery lifetime and maximum achievable charge capacity), it is important to monitor not only the concentration ratio of the main components (typically nickel, manganese, cobalt, and lithium in nickel manganese cobalt (NMC) batteries), but also trace impurities in both the precursor materials and the finished products. In general, inductively coupled plasma mass spectrometry (ICP-MS) is the preferred analytical technique for the analysis of metals and related contaminants at low levels (sub μg·L-1). However, the analysis of samples containing higher levels of total dissolved solids (TDS, typically above 0.5% weight/volume (w/v)) is a known challenge in ICP-MS. The complexity of the sample matrix can significantly affect the sensitivity of the instrument, cause intensity fluctuation (suppression and drift), and lead to increased system maintenance with unwanted downtime due to clogging of the interface cone orifices, torch injector, or nebulizer. Diluting high matrix samples with argon gas allows direct placement on the autosampler, eliminating the need for manual, time-consuming, off-line dilution.&nbsp;</p><p>A further challenge for the analysis of battery materials such as cathodes when using conventional, single quadrupole ICP-MS is the presence of polyatomic interferences generated by the principal components of the samples. For example, in addition to the well-known argon-based interferences, arsenic can be affected by a cobalt-based interference (59Co16O+). Since arsenic is monoisotopic at m/z 75, removal of this interference is crucial for accurate data. Furthermore, nickel oxide-based interferences can impact the determination of selenium using a single quadrupole ICP-MS system.&nbsp;</p><p>This application note describes an optimized analytical method for the analysis of nickel, manganese, and cobalt (NMC) based cathode materials. To overcome the analytical challenges described above, a triple quadrupole ICP-MS instrument, the <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/products/1488"><strong>Thermo Scientific™ iCAP™ MTX ICP-MS</strong></a>, was employed for the analysis. Use of triple quadrupole technology offered superior interference removal, and operation using Argon Gas Dilution (AGD) facilitated direct analysis of the samples derived from the digestion process. Adverse effects caused by the introduction of high matrix containing samples, such as more frequent maintenance, can also be reduced, thanks to the use of AGD. This enables more efficient laboratory workflow.</p><h4><strong>Conclusion&nbsp;</strong></h4><p>The iCAP MTX ICP-MS enables analysts to perform accurate and reliable elemental analysis in challenging samples such as digested cathode active materials. The proposed analytical method was evaluated for performance, and the results obtained clearly demonstrate the following analytical advantages for battery cathode sample analysis:&nbsp;</p><ul><li>The use of argon gas dilution (AGD) allows the direct analysis of acid digested samples so that labor-intensive manual sample dilutions can be omitted. At the same time, there is no increased need for system maintenance.&nbsp;</li><li>Using oxygen as a reactive gas in TQ-O₂ mode enabled sensitive, interference-free analysis of all analytes, including challenging ones like sulfur and arsenic.&nbsp;</li><li>Excellent CCV recovery and spike recovery results, as well as stable and consistent internal standards response, were obtained, demonstrating the reliability of the method<acknowledgement>The authors wish to express their heartfelt gratitude to Prof. Taichi Murakami of Tohoku University Graduate School of Environmental Studies (GSES) for his generous cooperation in providing the samples and instructions regarding the data analysis in the preparation of this Application News article.</acknowledgement></li></ul>

News from LabRulezICPMS Library - Week 30, 2026

Article

Product

Application

Water

Science and research

Since its establishment in 2011, CEITEC has quickly developed into a cutting-edge infrastructure for research which performs highly alongside the best institutes in Europe. Among the main priorities of CEITEC are the promotion of a motivating and dynamic international scientific environment, the provision of state-of-the-art research infrastructure, and the policy of open communication and equal opportunities.

CEITEC

A unique company dedicated to serving science helping our customers drive productivity and accelerate results. Through our premier brands – Thermo Scientific, Applied Biosystems, Invitrogen, Fisher Scientific and Unity Lab Services.

Thermo Fisher Scientific

Everything from the world of analytical chemistry in one place. We connect people in solving their problems. At Labrulez you will find all the necessary information easily, quickly and clearly. Stop searching and start finding.

LabRulez

Mettler-Toledo

Bruker

SelectScience

Wiley

C&EN

<p><strong>During this second session of a four-part ‘Fundamentals of Spectroscopy’ course, we will break down some common spectroscopic techniques (UV/VIS absorption spectroscopy, photoluminescence, and Raman scattering amongst others), examine how they work at a relatively low level, and discuss what they can be used to learn in different situations. We will pay special attention to the historical developments of these techniques, particularly the scientific and economic motivations that drove the people who created and refined them.</strong></p>
<p>Key learning objectives</p>
<ul>
<li><p><strong>Understand the concept of absorption spectroscopy, the design of an absorption spectrometer, and see how UV-VIS absorption spectroscopy can be used in quantifying protein concentration.</strong></p>
</li>
<li><p><strong>Differentiate between the different types of luminescence, specifically photoluminescence vs. fluorescence and understand the basics of fluorescence and phosphorescence spectrometers. Become familiar with applications using time-resolved fluorescence, solvatochromic shifts and Förster resonance energy transfer.</strong></p>
</li>
<li><p><strong>Learn the basics of Raman spectroscopy, and the design of a Raman spectrometer. Understand the units used in Raman spectroscopy and learn how Raman specificity can be used to measure various physical and chemical properties in materials.</strong></p>
</li>
</ul>
<blockquote>
<p><strong>Presenter</strong> Shayne Harrel (Andor Technology)</p>
</blockquote>
<blockquote>
<p>Shayne Harrel is a spectroscopy specialist for the Americas at Andor. He holds a PhD in physical chemistry from Yale University where he studied dynamical processes in charge transfer systems, magnetic materials and semiconductors using time-resolved terahertz spectroscopy. Prior to joining Andor, he was a senior applications engineer at MKS Instruments and has held previous positions as Chief Scientist-Americas for Izon Science, Senior Applications Scientist for Olympus Corporation, and as a chemist for the US Food and Drug Administration.</p>
</blockquote>
<blockquote>
<p><strong>Presenter</strong> Georgina Wynne Hughes (Editorial Team)</p>
</blockquote>
<blockquote>
<p>Georgina studied at Birmingham University where she gained a BSc in Biomedical Science, and an MSc by Research in Cancer and Genomic Sciences, which focused on defective autophagy in rare neurodegenerative diseases. As a member of the Editorial team, she now plays an integral role in shaping the content on SelectScience.</p>
</blockquote>


SelectScience: Spectroscopy techniques in practice: Methods and motivations

Spectroscopy techniques in practice: Methods and motivations

We will break down UV/VIS absorption spectroscopy, photoluminescence, and Raman scattering amongst others and examine how they work.

<p><strong>In this final session of a four-part ‘Fundamentals of Spectroscopy’ course, having now covered the basics, we will look at several advanced applications that do the seemingly impossible, from counting individual photons to looking inside exploding plasmas.</strong></p>
<p>We will examine both the immense technical challenges involved, as well as the scientific value they provide. We will look at several recent high-profile publications and break down how they work – what novel things the results tell us about the world, what equipment was used and why, and what made the measurements so difficult and noteworthy.</p>
<h5><strong>Key learning objectives</strong></h5>
<ul>
<li>Discover different camera designs such as CCDs, sCMOS, EMCCDs and intensified-gated CCDs.</li>
<li>Understand the signal-to-noise ratio in an optical measurement. Identify the distinct contributions to the overall noise. Learn about approaches to minimize sensor noise, as well as enhancing sensor sensitivity to optimize the signal-to-noise ratio in an optical measurement.</li>
<li>Discover how sensitivity in EMCCDs can be used to detect single photons in quantum optics and single molecule spectroscopy application.</li>
<li>Understand how intensified-gated CCDs can be used to obtain nanosecond time resolution in optical emission spectroscopy (OES) based plasma diagnostics.</li>
<li>Learn how intensified-gated scMOS cameras are used for high-speed, high-resolution micro-laser-induced breakdown spectroscopy (µ-LIBS) experiments.</li>
</ul>
<blockquote>
<p><strong>Presenter:</strong> Shayne Harrel (Andor Technology)</p>
</blockquote>
<blockquote>
<p>Shayne Harrel is a spectroscopy specialist for the Americas at Andor. He holds a PhD in physical chemistry from Yale University where he studied dynamical processes in charge transfer systems, magnetic materials and semiconductors using time-resolved terahertz spectroscopy. Prior to joining Andor, he was a senior applications engineer at MKS Instruments and has held previous positions as Chief Scientist-Americas for Izon Science, Senior Applications Scientist for Olympus Corporation, and as a chemist for the US Food and Drug Administration.</p>
</blockquote>
<blockquote>
<p><strong>Presenter:</strong> Georgina Wynne Hughes (Editorial Team)</p>
</blockquote>
<blockquote>
<p>Georgina studied at Birmingham University where she gained a BSc in Biomedical Science, and an MSc by Research in Cancer and Genomic Sciences, which focused on defective autophagy in rare neurodegenerative diseases. As a member of the Editorial team, she now plays an integral role in shaping the content on SelectScience.</p>
</blockquote>


SelectScience: Pushing the limits: Optical spectroscopy at the extremes

Pushing the limits: Optical spectroscopy at the extremes

We will look at several advanced applications that do the seemingly impossible, from counting individual photons to looking inside exploding plasmas.

<p><strong>Nowadays, the primary goals of battery research are to optimize production processes, innovate existing battery technologies, and develop new types of energy storage solutions that provide sufficient capacity, long lifespans, fast charging rates, safety, and eco-friendliness contributing to a fossil fuel-free future. Fulfilling these innovation requirements is based on the effective, comprehensive, structural, and chemical multiscale characterization of lithium-ion battery materials.</strong></p>
<p>This talk highlights the pivotal role of advanced microscopy techniques like Scanning Electron Microscopy (SEM), Focused Ion Beam-Scanning Electron Microscopy (FIB-SEM), Scanning Transmission Electron Microscopy (STEM), and micro-computed tomography (micro-CT) in characterizing conventional and next-gen lithium-ion battery materials.</p>
<p><strong>SEM</strong> provides detailed views of surface morphology, facilitating analysis of particle properties, degradation mechanisms, contaminants, and structural integrity.</p>
<p><strong>FIB-SEM</strong> extends this analysis with subsurface and three-dimensional characterization, revealing chemistry and internal micro- and nanostructures including solid electrolyte interphase, and phenomena like voids, cracks and delamination.</p>
<p><strong>STEM</strong> enables a nanoscale compositional characterization of battery active materials and components, including their surfaces and interfaces.</p>
<p><strong>Micro-CT</strong> offers non-destructive, three-dimensional imaging, capturing intricate details of the battery cell or module architecture and materials, all providing insights into battery quality, behavior, and failure mechanisms.</p>
<p>These techniques empower researchers to optimize battery properties, identify and prevent failure, and develop sustainable energy solutions. They address challenges posed by material chemistries and battery processes, guiding advancements in battery design and production.</p>
<blockquote>
<p><strong>Presenter:</strong> Dr. Dean Miller (Principal Scientist, TESCAN USA)</p>
</blockquote>
<blockquote>
<p>Dean Miller received his B.S. in Metallurgical Engineering and Ph.D. in Materials Science, both from the University of Illinois in Champaign-Urbana. He was a Senior Materials Scientist at Argonne National Laboratory for 30 years, including serving as Director for the Electron Microscopy Center at Argonne. His research focuses on the characterization of complex electronic oxides including advanced battery materials, magnetic oxides, and high-temperature superconductors with a particular emphasis on characterization by electron beam methods.</p>
</blockquote>
<blockquote>
<p><strong>Presenter:</strong> Vick Singh (Senior Vice President of Technology, Dragonfly Energy Corp.)</p>
</blockquote>
<blockquote>
<p>Vick Singh is an accomplished energy technology professional who has been instrumental in overseeing the development of next-generation lithium-ion batteries, manufacturing processes, and the optimization of battery chemistries. He holds a Ph.D. in Materials Science and Engineering from the University of Nevada, Reno, and a B.S. in Chemical Engineering from the University of Tennessee, Knoxville.</p>
</blockquote>


Wiley: Addressing Challenges in Lithium-Ion Battery Development and Production with Electron Microscopy and X-ray Microtomography

Addressing Challenges in Lithium-Ion Battery Development and Production with Electron Microscopy and X-ray Microtomography

The role Scanning Electron Microscopy (SEM), and other techniques in characterizing lithium-ion battery materials.

Challenges in Lithium-Ion Battery Development and Production

<p><strong>In this 4-part session you will gain insights and understanding of what you can do in the battery industry with varied technologies. From investigating solutes and electrodes, following battery cell behavior, and in situ research on energy storage materials the Bruker Scientists are sharing a wealth of knowledge for your research.</strong></p><p><strong>Session 1: 11:00 a.m.</strong></p><h5><strong>Powering the Future: Analytical Methods in Battery Research</strong></h5><p>Chemical understanding of batteries is essential for enhancing their performance, longevity, and safety. This session will highlight the role that analytical techniques play in battery research and development. By offering deep insights into the chemical, structural, and electrochemical properties of energy storage materials, these methods enable researchers to drive innovation and solve complex challenges. We'll provide an overview of key analytical approaches, including spectroscopy, solid-state NMR, and X-ray diffraction, and discuss their applications in advancing battery technology.</p><p><strong>Session 2: 11:25 a.m.</strong></p><h5><strong>Spectroelectrochemical Setup for Probing Reactions on Electrodes and in Electrolytes</strong></h5><p>Electrochemistry combined with vibrational spectroscopy provides powerful insights into electrochemical reactions and battery research through unique infrared and Raman signatures. The session will cover accessories, setup optimization, and applications like electro-oxidation of metal-organic complexes and lithium battery interface mapping.</p><p><strong>Session 3: 11:50 a.m.</strong></p><h5><strong>Advancements and Challenges of Solid-State NMR Technology for Battery Research</strong></h5><p>Solid-State Nuclear magnetic resonance (NMR) is a characterization technique applied to investigate the structural changes of/in battery materials. Advanced NMR approaches can be used to track and examine ion-exchange/diffusion across interfaces, electrolyte decomposition, dendrite formation, storage behavior of an electrode etc. during or following charging/discharging in order to understand electrochemical processes and improve battery properties.</p><p><strong>Session 4: 12:15 p.m.</strong></p><h5><strong>Charge and Structure: Understanding Batteries Through X-Ray Diffraction</strong></h5><p>X-ray diffraction (XRD) serves as a powerful tool for elucidating the structural properties of battery materials at the atomic scale. Modern XRD techniques can be used to understand the effects of cycling and synthesis methods on electrode stability and efficiency, ultimately guiding the development of next-generation energy storage solutions.</p><p><strong>Key Learning Objectives:</strong></p><ul><li>Gain an overview of current trends in battery technology.</li><li>Understand the key components of battery chemistry and design.</li><li>Learn about future trends in battery development and energy storage.</li></ul><p><strong>Who Should Attend:</strong></p><ul><li>Laboratory managers</li><li>Batteries developers</li><li>Electrochemical researchers</li></ul><blockquote><p><strong>Presenter:</strong> Federico Paruzzo, PhD (Academic Market Project Manager, Bruker BBIO)</p><p><strong>Presenter: </strong>Sergey Shilov, PhD (NA Product Manager, Science, Bruker Optics)</p><p><strong>Presenter: </strong>Edina Sic (Solutions Product Manager, Academic Battery Research, Bruker BioSpin Group)</p><p><strong>Presenter: </strong>Nick Rodesney (XRD Applications Scientist, Bruker)</p><p><strong>Presenter:</strong> Ann Thayer (Contributing Editor, C&amp;EN Media Group)</p></blockquote>

The Science of Batteries

In this 4-part session you will gain insights and understanding of what you can do in the battery industry with varied technologies.

<p><strong>Nuclear Magnetic Resonance (NMR) technology offers a powerful, versatile solution for food profiling, providing significant return on investment (ROI) through its various applications. This webinar will delve into the basics of NMR, explore specific food profiler solutions, and highlight the versatility of NMR with different upgradation options. Additionally, we will cover statistical analysis using Mestre Software for chemometric analyses of NMR data from various food matrices.</strong></p><div><h3><strong>Key Learning Topics</strong></h3></div><div><div><div><div><div><div><p><strong>Introduction to NMR</strong></p><ul><li>Basics of NMR: Understanding the fundamental principles and applications of Nuclear Magnetic Resonance.</li><li>Avance Chemical Profiling (ACP) for Simple Mixture Analyses: Providing quick and reliable results for straightforward mixture analysis.</li></ul><p><strong>Food Profiler Solutions - Complex Mixture Analysis</strong></p><ul><li>Honey Profiler: Addressing the challenges of honey authenticity control and demonstrating the ROI of using NMR for honey analysis.</li><li>Juice Profiler: Highlighting the benefits of NMR in analyzing juice for purity and composition.</li><li>Wine Profiler: Exploring how NMR can be used to profile wine, ensuring quality control and detecting adulteration.</li><li>Olive Oil Profiler: Emphasizing the advantages of NMR in verifying the authenticity and quality of olive oil.</li></ul><p><strong>NMR as a Versatile Tool</strong></p><ul><li>The BBFO CryoProbe for Routine Work: Enhancing efficiency in routine NMR analyses.</li><li>Solids ,HR-MAS and cryo probes (Liquid Nitrogen and Liquid Helium): Expanding the versatility of NMR to analyze solid, semi-solid and solution samples.<br>&nbsp;</li></ul><p><strong>Statistical Analysis Using Mestre Software</strong></p><ul><li>Presentation from Mestre: Showcasing how the software can be used for chemometric analyses of NMR data from different food matrices. This segment will require approval from the development team to ensure compatibility and effectiveness.</li></ul><div><h3><strong>Who Should Attend</strong></h3></div><div><div><div><div><div><div><p><strong>This webinar is designed for professionals involved in food quality and authenticity, including:</strong></p><ul><li>Food packers, exporters, and importers</li><li>Commercial analytical service providers</li><li>Regulatory or governmental bodies</li><li>Food producer associations</li></ul><p>Join us to gain valuable insights into the applications of NMR technology in food profiling and statistical analysis, and learn how these tools can enhance the authenticity, integrity, and economic viability of various food products.</p><blockquote><p><strong>Presenter: </strong>Ph.D. Pedro Lopes (Field Application Scientist, Bruker BioSpin GmbH, Ettlingen)</p><p>Pedro Lopes holds a doctoral degree in Biophysics with experience in X-Ray Crystallography and High Resolution NMR of Proteins. As a Researcher, he applied High Pressure NMR to Proteins for discovering rare conformational states and new binding sites for interaction with small drugs. He joined Bruker in 2022 where he works as a Field Application Specialist for new solutions in the Applied, Industrial and Clinical Markets</p><p><strong>Presenter: </strong>Uday Ramesh Prabhu (Sales Manager, Biopharma &amp; Applied Division, Bruker India Scientific Pvt.Ltd. Mumbai)</p><p>Uday is currently Sales Manager and Applications Scientist – Cleantech, Industrial and Applied Market (CIAM) division of Bruker Biospin Group. He started his professional career as an Application Scientist with Bruker India Scientific Pvt. Ltd., Mumbai, in 2012. Covering mainly Nuclear Magnetic Resonance (NMR) and Electron Paramagnetic Resonance (EPR/ESR) product portfolio -floor standing and benchtop NMR systems like Minispec and Fourier 80, catering to food and industry markets. Also, in charge of demo lab at Mumbai for benchtop NMR and EPR systems. He obtained his Ph.D. from Indian Institute of Science, Bangalore in 2010, and then pursued post-doc research at the University at Buffalo-SUNY, USA.</p><p><strong>Presenter: </strong>Sandeep Baluni (Strategic Account Director, Mestrelab Research S.L.)</p><p>Mr. Sandeep Baluni holds a Master’s degree in Organic Chemistry and a Postgraduate Certification in AI &amp; ML. He brings over 25 years of diverse experience in business development across prominent organizations, including GSK, Reliance Industries, Elsevier, ACD Labs, and Information Mapping. Currently, working as the Director, Strategic Accounts at Mestrelab Research. Mr. Baluni combines his technical expertise with strategic industry insight to drive innovation and growth in scientific softwaresolutions</p></blockquote></div></div></div></div></div></div></div></div></div></div></div></div>

Bruker: Ensure Food Authenticity & Quality with NMR: Advanced Profiling Solutions

Ensure Food Authenticity & Quality with NMR: Advanced Profiling Solutions

This webinar will delve into the basics of NMR, explore specific food profiler solutions and highlight the versatility of NMR with different upgradation options

Ensure Food Authenticity & Quality with NMR

<div><p><strong>This webinar will provide an overview of Chemical Exchange Saturation Transfer (CEST) MRI, from its physical principles and experimental design to the key factors influencing endogenous CEST signals in vivo. We will explore both physiological and technical sources of contrast, the complexity of in vivo CEST signals, and common artifacts such as fat contamination and field inhomogeneities.</strong></p><p>The session will also highlight essential correction strategies for achieving quantitative CEST MRI and showcase current applications in cancer and neuroimaging. Preclinical studies at ultra-high magnetic fields—such as the DKFZ’s 9.4 T Bruker system—play a key role in advancing methodological development, enabling a deeper understanding of complex CEST signal behavior in vivo and paving the way for clinical translation.</p><h5><strong>What to Expect</strong></h5><p>Join Dr. Philip S. Boyd for an in-depth exploration of Chemical Exchange Saturation Transfer (CEST) MRI, covering its theoretical foundations, practical implementation, and cutting-edge applications in cancer and neuroimaging. This webinar will guide attendees through the complexities of in vivo CEST signals, correction strategies for artifacts, and the translation of preclinical findings into clinical practice.</p><h5><strong>Key Learning Points</strong></h5><ul><li>Understanding the CEST Phenomenon and Theory</li><li>Applications in Cancer and Neuroimaging</li><li>Achieving Quantitative CEST imaging In Vivo</li></ul><h5><strong>Who should attend:</strong></h5><p>This webinar is ideal for researchers, clinicians, and imaging specialists working in MRI, oncology, neurology, or molecular imaging who are interested in advancing their understanding of quantitative CEST techniques and their translational potential. It will also be highly educational for graduate students and early-career scientists beginning their journey in MRI, offering foundational insights and practical guidance.</p><blockquote><p><strong>Presenter:</strong> Dr. Philip S. Boyd (Ph.D. in Physics from Heidelberg University and leads the CEST Imaging Group at the German Cancer Research Center (DKFZ) in Heidelberg)</p><p>Dr. Philip S. Boyd holds a Ph.D. in Physics from Heidelberg University and leads the CEST Imaging Group at the German Cancer Research Center (DKFZ) in Heidelberg. His research focuses on developing and refining advanced CEST imaging techniques, including pH imaging and fat artifact correction. He combines experimental imaging, mathematical modeling, and data analysis to drive CEST applications from preclinical research to clinical translation.</p></blockquote></div>

Bruker: Quantitative CEST MRI: From Principles to Applications in Cancer and Neuroimaging

Quantitative CEST MRI: From Principles to Applications in Cancer and Neuroimaging

Discover how CEST MRI works and how it's applied in cancer and neuroimaging. With insights from DKFZ’s cutting-edge preclinical studies.

Quantitative CEST MRI: From Theory to Clinical Insight

<header><h4><strong>Discover Useful Applications for Characterizing These Unique Materials</strong></h4></header><main><div><div><h5><strong>Program</strong></h5><ul><li>Introduction to nanomaterials</li><li>Basic properties and uses</li><li>Relevant thermal analysis techniques</li><li>Industries and suitable investigations</li><li>Application examples for industry and research (DSC, Flash DSC, TGA, and DMA)</li><li>Interactive Q&amp;A session</li></ul></div></div><div><div><div><p>Nanomaterials exhibit unique and diverse properties that enable a wide range of innovative applications. Their unique properties enhance catalysis, improve mechanical strength, and can even provide antibacterial effects in clothing. Their nanoscale size facilitates nucleation and also influences magnetic behavior.</p><p>Understanding the behavior of nanomaterials is crucial for harnessing their unique properties. This knowledge enables their use in advanced materials and innovative technological applications.</p><p><strong>Join our live webinar to explore how thermal analysis techniques can reveal the unique properties of nanomaterials.</strong></p><p>Be sure to prepare your questions for the live Q&amp;A with our experts!</p><h4><strong>Thermal Analysis Techniques for Characterizing Nanomaterials</strong></h4><ul><li><strong>DSC and Flash DSC</strong> are important techniques used to determine the glass transition, melting, crystallization behavior, reaction enthalpies and kinetics, and the influence of nanoparticle fillers.</li><li><strong>TGA</strong> is used to investigate stability, decomposition behavior and water sorption of nanomaterials.</li><li><strong>DMA</strong> is useful for characterizing the influence of nanoparticles on the mechanical behavior of viscoelastic materials as a function of time, temperature, and frequency of an oscillating stress.</li></ul><p>Don't miss the chance to deepen your understanding of thermal analysis techniques for characterizing these unique materials. Reserve your spot today!</p><h4><strong>Properties and Uses of Nanomaterials</strong></h4><p>The unique properties of nanomaterials enable diverse applications. For example, due to their high surface area, inefficient or unfavorable chemical reactions can often be improved by nanoparticle <strong>catalysts</strong>. When integrated into bulk materials, nanoparticles can <strong>tailor mechanical properties</strong> for advanced performance. Silver nanoparticles impart <strong>antibacterial qualities to clothing</strong>, preventing odors by eliminating bacteria. Additionally, their nanoscale size facilitates <strong>nucleation</strong>, aiding crystallization of larger molecules that would otherwise have difficulty crystallizing on their own.</p><p>Other uses of nanomaterials include structures such as <strong>silica gels </strong>and <strong>molecular sieves</strong> that have functional geometries on a nanoscale. Magnetic behavior can also vary with nanoparticle size, influencing <strong>magnetization dynamics</strong>.</p><p>These fascinating characteristics make nanomaterials pivotal in cutting-edge technology and materials science.&nbsp;</p></div><div><div data-advanced-option="false" data-has-preview-image="false" data-video-id="" data-component-id="2110920040"><div style="max-width:1px;width:100%;" id="mediaContainerWrapper_2110920040"><div style="height:1px;width:1px;" data-external-url="" id="mediaContainer_2110920040" data-advanced-option="false" data-width="1" data-height="1" data-video-id="">&nbsp;</div></div></div></div></div></div></main><div><div><div data-advanced-option="false" data-has-preview-image="false" data-video-id="" data-component-id="2110920040"><blockquote><div><strong>Presenter: </strong>Nicolas Fedelich</div><p>With a background in chemical engineering, Nicolas joined METTLER TOLEDO in 2009 as an application specialist for thermal analysis. Before that, he gained expertise in different laboratories implementing, developing, and validating analytical methods in both the pharmaceutical and environmental fields. Nicolas also worked for three years in the field carrying out on-site customer training and providing expert thermal analysis application support. In his present position, Nicolas expertly uses, teaches, and supports DSC, TGA, TMA, and DMA instruments at the METTLER TOLEDO head office in Switzerland.</p></blockquote></div></div></div>

Mettler Toledo: Thermal Analysis of Nanomaterials

Thermal Analysis of Nanomaterials

Join our live webinar to explore how thermal analysis techniques can reveal the unique properties of nanomaterials.

ICPMS webinars focusing on Academy/Principles - page 1