<h4><strong>Overcoming matrix suppression and signal drift in environmental samples and industrial brines</strong></h4><p>As demand for lithium, rare earth elements (REEs), and environmental monitoring continues to grow, laboratories are increasingly challenged by one of the most difficult sample types in elemental analysis: high-salinity waters. Whether analyzing lithium-rich underground brines for electric vehicle battery production or monitoring seawater and brackish water for environmental compliance, laboratories require a solution that combines sensitivity, robustness, and productivity.</p><p>The <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/products/1487"><strong>Thermo Scientific iCAP MSX ICP-MS</strong></a> addresses these challenges by delivering reliable trace element analysis across a wide range of salt concentrations—from seawater to highly concentrated brines containing up to 25% sodium chloride.</p><h3><strong>Why high-salt samples challenge ICP-MS</strong></h3><p>Brines and seawater present significant analytical obstacles.<strong> High dissolved solids can cause:</strong></p><ul><li>Signal drift and matrix suppression</li><li>Nebulizer blockages</li><li>Torch injector fouling</li><li>Interface cone contamination</li><li>Increased maintenance and downtime</li></ul><p>Traditional workflows often require extensive manual dilution, frequent recalibration, and additional operator intervention. These steps reduce throughput and increase operating costs.</p><h3><strong>A unified solution for brines and seawater</strong></h3><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Fisher_Scientific_Trace_Metal_Analysis_in_High_Salt_Matrices_by_ICP_MS_4_78a4a8997a.jpg" alt="Thermo Fisher Scientific: Trace Metal Analysis in High Salt Matrices by ICP-MS" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Fisher_Scientific_Trace_Metal_Analysis_in_High_Salt_Matrices_by_ICP_MS_4_78a4a8997a.jpg 245w," sizes="100vw" width="1808" height="900"></p><p>The<strong> iCAP MSX ICP-MS</strong> leverages integrated <strong>Argon Gas Dilution (AGD) technology</strong> to enable direct analysis of challenging high-matrix samples while maintaining excellent sensitivity and stability.</p><p><strong>Key advantages include:</strong></p><ul><li>Analysis of brines up to <strong>25% NaCl </strong>without manual dilution</li><li>High matrix tolerance with the AGD High setting</li><li>Automated tuning and instrument health monitoring</li><li>Stable internal standard performance</li><li>Reduced maintenance requirements</li><li>Consistent data quality across varying salt concentrations</li><li>Reduced sample handling, dilution apparatus, and potential for contamination</li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Fisher_Scientific_Trace_Metal_Analysis_in_High_Salt_Matrices_by_ICP_MS_3_785f2e2d29.jpg" alt="Thermo Fisher Scientific: Trace Metal Analysis in High Salt Matrices by ICP-MS" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Fisher_Scientific_Trace_Metal_Analysis_in_High_Salt_Matrices_by_ICP_MS_3_785f2e2d29.jpg 221w," sizes="100vw" width="1400" height="989"></p><p>This unified approach allows laboratories to use a <strong>single method for multiple sample types</strong>, improving efficiency and simplifying operations.</p><h3><strong>Engineered for robustness</strong></h3><p><strong>Several hardware innovations contribute to the system’s performance:</strong></p><p><strong>Collision / Reaction Cell</strong><br>The Thermo Scientific QCell Collision / Reaction Cell utilizes a proprietary Flatapole design and integrated low-mass cutoff technology to provide effective interference removal while maintaining high ion transmission and sensitivity.</p><p><strong>RAPID lens technology</strong><br>The Right Angle Positive Ion Deflection (RAPID) lens system uses a fully focused 90-degree ion deflection design that helps keep the mass spectrometer maintenance-free after the interface region.</p><p><strong>Flexible AGD operation</strong><br>Unlike alternative matrix-handling approaches, AGD offers selectable dilution levels fully integrated within the <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/products/1489"><strong>Thermo Scientific Qtegra Intelligent Scientific Data Solution (ISDS) software</strong></a>, simplifying operation while maintaining performance.</p><h3><strong>Supporting the growing lithium and rare earth economy</strong></h3><p>The rapid expansion of electric vehicle production has intensified the need for reliable impurity analysis in lithium-rich underground brines. Accurate determination of trace metals and rare earth elements is essential for:</p><ul><li>Resource characterization</li><li>Process optimization</li><li>Product quality assurance</li><li>Regulatory compliance</li></ul><p>The ability to analyze both concentrated brines and seawater using a single workflow enables laboratories to support upstream extraction, refining operations, and environmental monitoring with greater efficiency.</p><h3><strong>Improving productivity through intelligent automation</strong></h3><p>Beyond analytical performance, the<strong> iCAP MSX ICP-MS</strong> is designed to reduce the operator’s workload through:</p><ul><li>Automatic instrument tuning</li><li>Integrated health monitoring</li><li>Hawk Consumables and Maintenance Assistant</li><li>Simplified maintenance planning</li><li>Reduced risk of unplanned downtime</li></ul><p>These features help laboratories maximize instrument uptime while maintaining confidence in data quality.</p><h3><strong>Seawater validation data demonstrates excellent accuracy and sensitivity</strong></h3><p>To evaluate analytical performance in a challenging marine matrix, seawater samples were analyzed both unspiked and with trace-element spike additions of <strong>1 ppb and 0.1 ppb</strong>. The study included transition metals, precious metals, and Rare Earth Elements (REEs) measured using KED mode.</p><h5><strong>1 ppb spike recovery results</strong></h5><p>The 1 ppb spike experiment demonstrated strong recoveries across most analytes:</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Fisher_Scientific_Trace_Metal_Analysis_in_High_Salt_Matrices_by_ICP_MS_c27a27a631.jpg" alt="Thermo Fisher Scientific: Trace Metal Analysis in High Salt Matrices by ICP-MS" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Fisher_Scientific_Trace_Metal_Analysis_in_High_Salt_Matrices_by_ICP_MS_c27a27a631.jpg 110w," sizes="100vw" width="834" height="1180"></p><p>The majority of REEs showed recoveries between approximately <strong>102% and 116%</strong>, demonstrating excellent accuracy in a high-salt seawater matrix. Particularly noteworthy were <strong>Er (115.6%), Dy (114.9%), Yb (114.0%), and Gd (114.0%)</strong>, highlighting the capability of the system for strategic element monitoring.</p><h5><strong>0.1 ppb spike recovery results</strong></h5><p>Performance remained strong at ten-fold lower concentration levels:</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Fisher_Scientific_Trace_Metal_Analysis_in_High_Salt_Matrices_by_ICP_MS_2_d045eb8be8.jpg" alt="Thermo Fisher Scientific: Trace Metal Analysis in High Salt Matrices by ICP-MS" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Fisher_Scientific_Trace_Metal_Analysis_in_High_Salt_Matrices_by_ICP_MS_2_d045eb8be8.jpg 115w," sizes="100vw" width="834" height="1129"></p><p>These results demonstrate reliable quantification at sub-ppb concentrations, supporting environmental monitoring and trace impurity applications where ultra-low detection capability is essential.</p><h3><strong>What does this mean for laboratories?</strong></h3><p>The seawater data confirms that the iCAP MSX ICP-MS can deliver:</p><ul><li>Accurate recovery of trace metals and rare earth elements</li><li>Reliable measurements at low and sub-ppb concentrations</li><li>Excellent sensitivity across a broad elemental range</li><li>Robust operation in challenging high-salt matrices</li><li>A single workflow applicable for seawater, brackish water, and concentrated brines</li></ul><p>For laboratories supporting lithium extraction, critical minerals programs, environmental monitoring, or industrial process control, these capabilities translate directly into higher confidence in analytical results and increased operational efficiency.</p><h3><strong>Conclusion</strong></h3><p>As industries increasingly rely on accurate elemental analysis of high-salinity samples, laboratories need instrumentation capable of balancing sensitivity, robustness, and productivity. The<a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/products/1487"><strong> iCAP MSX ICP-MS </strong></a>provides a comprehensive solution for both industrial brine applications and environmental seawater monitoring, delivering accurate recoveries, low detection limits, and reliable performance across some of the most challenging matrices encountered in ICP-MS analysis.</p><p>From lithium extraction to environmental stewardship, the future of trace element analysis depends on technologies that can turn difficult samples into dependable data.</p><blockquote><p>Register for our on-demand webinar to learn more about the iCAP MX Series ICP-MS <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/webinar/6398"><strong>New ICP-MS innovations to ignite productivity and efficiency in your laboratory</strong></a></p></blockquote><ul><li><strong>Visit us on&nbsp;</strong><a target="_blank" rel="noopener noreferrer" href="https://www.linkedin.com/showcase/72003132/admin/dashboard/"><strong><u>LinkedIn:</u></strong></a>&nbsp;#ICPMS #EnvironmentalTesting #REEs #ElementalAnalysis</li></ul>

Trace Metal Analysis in High Salt Matrices by ICP-MS

<p><strong>Colourful vortices, loops and currents resembling magnetic storms or abstract digital art. This is what maps of magnetically induced electron currents look like, created by an international team including chemists from CEITEC Masaryk University while studying molecules containing gold, mercury and the rare element astatine.</strong></p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/CEITEC_Chemici_z_CEITEC_zachytili_elektronove_boure_ve_zlate_a_rtuti_4_7b12d14b21.jpeg" alt="CEITEC: CEITEC Chemists Capture Electron Storms in Gold and Mercury" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_CEITEC_Chemici_z_CEITEC_zachytili_elektronove_boure_ve_zlate_a_rtuti_4_7b12d14b21.jpeg 245w," sizes="100vw" width="1600" height="834"></p><p>What may at first glance resemble visualisations of outer space or ocean currents is in fact taking place inside molecules themselves. Here, electrons form complex currents and vortices whose shapes vary depending on the <strong>type of atom and the nature of the chemical bond.</strong></p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/CEITEC_Chemici_z_CEITEC_zachytili_elektronove_boure_ve_zlate_a_rtuti_3_9e2f79434f.jpeg" alt="CEITEC: CEITEC Chemists Capture Electron Storms in Gold and Mercury" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_CEITEC_Chemici_z_CEITEC_zachytili_elektronove_boure_ve_zlate_a_rtuti_3_9e2f79434f.jpeg 245w," sizes="100vw" width="1600" height="834"></p><p>And this is where Einstein enters the picture. In heavy elements, electrons move so rapidly that their behaviour is influenced by the effects of special relativity. Without relativistic physics, some of these remarkable electron patterns would not exist at all.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/CEITEC_Chemici_z_CEITEC_zachytili_elektronove_boure_ve_zlate_a_rtuti_8_5fc3a0ed98.jpeg" alt="CEITEC: CEITEC Chemists Capture Electron Storms in Gold and Mercury" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_CEITEC_Chemici_z_CEITEC_zachytili_elektronove_boure_ve_zlate_a_rtuti_8_5fc3a0ed98.jpeg 245w," sizes="100vw" width="1600" height="827"></p><p>While some atoms are surrounded by almost perfectly symmetrical current flows, others generate distorted vortices or local turbulences resembling miniature electron storms. Using <strong>advanced computational methods</strong>, the researchers were able to capture these differences in unprecedented detail.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/CEITEC_Chemici_z_CEITEC_zachytili_elektronove_boure_ve_zlate_a_rtuti_5_0e0f36c76a.jpeg" alt="CEITEC: CEITEC Chemists Capture Electron Storms in Gold and Mercury" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_CEITEC_Chemici_z_CEITEC_zachytili_elektronove_boure_ve_zlate_a_rtuti_5_0e0f36c76a.jpeg 245w," sizes="100vw" width="1600" height="834"></p><p>The results provide not only new insights into the behaviour of heavy elements but also a visually fascinating glimpse into a world that normally remains hidden from human eyes.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/CEITEC_Chemici_z_CEITEC_zachytili_elektronove_boure_ve_zlate_a_rtuti_7_462defafce.jpeg" alt="CEITEC: CEITEC Chemists Capture Electron Storms in Gold and Mercury" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_CEITEC_Chemici_z_CEITEC_zachytili_elektronove_boure_ve_zlate_a_rtuti_7_462defafce.jpeg 245w," sizes="100vw" width="1600" height="834"></p><p>Scientists study such phenomena because the behaviour of electrons determines how stable molecules are, how they react, and what properties they possess. In heavy elements, however, the rules of classical chemistry often reach their limits – and relativity comes into play.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/CEITEC_Chemici_z_CEITEC_zachytili_elektronove_boure_ve_zlate_a_rtuti_01832dca81.jpeg" alt="CEITEC: CEITEC Chemists Capture Electron Storms in Gold and Mercury" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_CEITEC_Chemici_z_CEITEC_zachytili_elektronove_boure_ve_zlate_a_rtuti_01832dca81.jpeg 245w," sizes="100vw" width="1600" height="834"></p><p>A better understanding of these effects could eventually contribute to the design of new catalysts or materials based on heavy metals. For the researchers themselves, studying such electron structures is also a way of exploring one of the least intuitive realms of modern chemistry.</p><p>The study was published in <a target="_blank" rel="noopener noreferrer" href="https://doi.org/10.1021/jacsau.6c00346"><strong>JACS Au</strong></a>.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/CEITEC_Chemici_z_CEITEC_zachytili_elektronove_boure_ve_zlate_a_rtuti_6_a2a8433b8b.jpeg" alt="CEITEC: CEITEC Chemists Capture Electron Storms in Gold and Mercury" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_CEITEC_Chemici_z_CEITEC_zachytili_elektronove_boure_ve_zlate_a_rtuti_6_a2a8433b8b.jpeg 245w," sizes="100vw" width="1600" height="834"></p><blockquote><h4><strong>Original article</strong></h4><h4><a target="_blank" rel="noopener noreferrer" href="https://pubs.acs.org/doi/10.1021/jacsau.6c00346"><span><strong>Link between Spin–Orbit Relativity and Magnetically Induced Current Densities in Heavy-Atom Hydrides: </strong></span><i><span><strong>trans</strong></span></i><span><strong>-Ligand Influence</strong></span></a></h4><p>Daniel Blasco, Jan Novotný, James R. Asher, Raphael J. F. Berger, Stanislav Komorovsky, Radek Marek</p><p><i><span><strong>JACS Au</strong></span></i><strong> </strong><span>2026, 6, 6, 3323–3335</span></p><p><a target="_blank" rel="noopener noreferrer" href="https://doi.org/10.1021/jacsau.6c00346">https://doi.org/10.1021/jacsau.6c00346</a></p><h6>licensed under <a target="_blank" rel="noopener noreferrer" href="https://creativecommons.org/licenses/by/4.0/">CC-BY 4.0&nbsp;</a></h6></blockquote><h4><strong>Abstract</strong></h4><p>Interactions between individual atoms underpin the structure and behavior of matter. These interactions govern atomic positions and dynamics, as well as the organization of electrons─particularly in the frontier region. Because electrons lie at the core of chemical phenomena, numerous theoretical frameworks have been developed to rationalize the molecular structure and properties. Electronic motion within molecules and the resulting induced currents provide powerful probes of the molecular or supramolecular structure, building on and going beyond molecular orbital and valence bond theories. In particular, current density offers a spatially-resolved description of the electronic response to external perturbations, enabling direct analysis of electron delocalization and magnetic response in molecular systems. In this work, the effect of relativistic spin–orbit (SO) coupling on the strength and topology of the magnetically induced current density (MICD) is analyzed in depth for a series of model heavy-atom hydrides at the four-component Dirac-Kohn–Sham level. For the most simple molecules, TlH, HAt, and AuH, we demonstrate a connection between the SO effects on the molecular geometry, strength and topology of MICDs, and ligand <sup>1</sup>H NMR shielding. For model <strong>HMX</strong> molecules, where M = Au<sup>I</sup>, Hg<sup>II</sup>; X = F, Cl, Ph, CH<sub>3</sub>, H, SiH<sub>3</sub>, BH<sub>2</sub>, the hydride deshielding due to the slight elongation of the M–H bond upon increasing the <i>trans</i>-ligand influence (TLI) of X is shown to be marginal when compared to that originating from the electronic SO effect. In particular, the inclusion of SO effects gives rise to highly localized paratropic MICD vortices on the hydride position of those complexes bearing strong TLI ligands. Our results disprove the previously proposed governing role of the current around the metal atom (similar to the classical Buckingham-Stephens model for transition metal hydrides) associated with TLI-induced variations in the metal–hydrogen bond length in determining the characteristic ligand <sup>1</sup>H NMR shifts.</p>

CEITEC Chemists Capture Electron Storms in Gold and Mercury 

<p><strong>Our Library never stops expanding. What are the most recent contributions to LabRulezICPMS Library in the week of 20th July 2026? Check out new documents from the field of spectroscopy/spectrometry and related techniques!</strong></p><blockquote><p><span style="font-size:20px;">👉 </span><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/library"><span style="font-size:20px;"><strong>SEARCH THE LARGEST REPOSITORY OF DOCUMENTS ABOUT SPECTROSCOPY/SPECTROMETRY RELATED TECHNIQUES</strong></span></a></p></blockquote><blockquote><p><strong>👉 Need info about different analytical techniques?</strong> Peek into <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/library"><strong>LabRulezLCMS</strong></a> or <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library"><strong>LabRulezGCMS</strong></a> libraries.</p></blockquote><p>This week we bring you application notes by <strong>Agilent Technologies,</strong> <strong>Shimadzu </strong>and <strong>Thermo Fisher Scientific!</strong></p><h3><strong>1. Agilent Technologies: Analysis of Elemental Impurities in GLP-1 Receptor Agonist Oral Tablets by ICP-MS</strong></h3><ul><li>Application note</li><li><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/labrulez-bucket-strapi-h3hsga3/an_glp_1_receptor_tablets_7850_icp_ms_5994_9317en_agilent_c355750808.pdf"><strong>Full PDF for download</strong></a><strong>&nbsp;</strong></li></ul><p>Glucagon-like peptide-1 (GLP-1) receptor agonists represent a rapidly expanding class of therapeutics for the management of type 2 diabetes and chronic weight management. While many approved GLP-1 receptor agonists are administered by subcutaneous injections, oral formulations are generating significant clinical and commercial interest. However, formulating peptide-based therapeutics as oral solid dosage forms introduces additional manufacturing complexity, including the need for permeation enhancers, excipients, and coating materials. Each of these components presents a potential source of elemental impurity contamination. International or national-based regulatory authorities are responsible for ensuring that pharmaceutical products are both effective and safe for use. Control of elemental impurities in drug products is governed by the International Council for Harmonisation (ICH) Guideline for Elemental Impurities, Revision 2 (Q3D(R2))<sup>1</sup> and United States Pharmacopeia (USP) &lt;232&gt;/&lt;233&gt; (Elemental Impurities — Limits and Procedures)<sup>2,3</sup> using ICP-OES- or ICP-MS-based instrumental methods.</p><p>The USP chapters classify 24 elemental impurities in three classes based on toxicity and probability of occurrence, with permitted daily exposure (PDE) limits defined by route of administration. Analytical method validation follows ICH Q2(R2) (Validation of Analytical Procedures, 2023)<sup>4</sup> and the harmonized USP &lt;1225&gt; (Validation of Compendial Procedures)<sup>5</sup> , with system suitability criteria defined in USP &lt;233&gt;.<sup>3</sup> ICH Q2(R2) provides updated guidance on the validation of analytical procedures that is applicable to biological- and biotechnology-derived products. The revised guideline offers clearer guidance on complex therapeutics, such as peptide-based biotherapeutics, including GLP-1 receptor agonists—an area not specifically addressed in the earlier Q2(R1) framework.&nbsp;</p><p>In this study, an analytical method was developed and validated in accordance with USP &lt;232&gt;/&lt;233&gt; and ICH Q3D(R2)/Q2(R2). The method enables quantitative determination of all 24 regulated elemental impurities in an oral tablet of a GLP-1 receptor agonist using an <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/library?mainauthorItems=10&amp;search=7850"><strong>Agilent 7850 ICP-MS</strong></a><strong>.</strong> The instrument features an integrated fourthgeneration Octopole Reaction System (ORS<sup>4</sup>) collision cell, which was operated in helium (He) mode to provide robust suppression of matrix-derived polyatomic interferences affecting the analytes. Data were acquired to evaluate drift/ stability, detectability, precision (repeatability and intermediate precision), specificity, accuracy, and linearity. </p><h4><strong>Results and discussion&nbsp;</strong></h4><p>Before being used for limit or quantitative procedures, the analytical instrument and method must meet performance criteria defined in ICH Q2(R2) and USP &lt;233&gt;. System suitability—verified by confirming that results remain stable (drift ≤ 20%) throughout the analytical run—must be demonstrated on the day of analysis. Separately, USP &lt;233&gt; requires procedure validation to demonstrate fitness for purpose: detectability, precision, and specificity for Limit Procedures; and accuracy, precision/repeatability, intermediate precision (ruggedness), specificity, limit of quantitation, linearity and range (demonstrated across 0.5–1.5 J) for Quantitative Procedures.</p><h4><strong>Speciation considerations for As and Hg&nbsp;</strong></h4><p>For some elements, toxicity is highly dependent on their chemical form. Of the analytes listed in the ICH/USP regulations, As and Hg are of particular concern. The PDE limit for both elements refers to their inorganic forms because inorganic As is the most toxic, and inorganic Hg is considered the most likely form to be present in pharmaceutical materials.&nbsp;</p><p>If the measured total As concentration exceeds the target concentration, USP &lt;232&gt; suggests that a speciation analysis is performed using LC-ICP-MS to allow independent quantification of inorganic As. If inorganic As is found to be below the limit, the material would be considered compliant even if total As exceeds the limit. The speciation of Hg should be established if the test material is likely to contain the more toxic methyl Hg species (for example, ingredients sourced from marine-derived materials). Otherwise, compliance is established by determining total Hg.&nbsp;</p><p>In this study, only trace-level Li (0.23 ppb) and Ni (0.07 ppb) were detected in the sample blank. All other elements were below the IDLs. Therefore, speciation analysis on As and Hg was not required. However, the 7850 ICP-MS can be easily integrated with an Agilent LC system for routine speciation analysis if needed.<sup>7</sup></p><h4><strong>Conclusion&nbsp;</strong></h4><p>This study demonstrates the suitability of the Agilent 7850 ICP-MS for the identification and quantification of 24 regulated elemental impurities in a GLP-1 receptor agonist oral tablet formulation, prepared by microwave digestion. The instrument’s ORS4 collision cell was operated in helium mode, providing robust, non-specific attenuation of matrixderived polyatomic interferences. The method successfully met the limit and accuracy requirements specified in USP &lt;232&gt;/&lt;233&gt; and ICH Q3D(R2)/Q2(R2) guidelines, ensuring reliable multi-element quantification of GLP-1 tablets without the need for element-specific method optimization. F</p><p>or pharmaceutical QC laboratories, the Agilent ICP-MS MassHunter instrument control software assisted in developing the workflow, reducing the time and effort required to establish a compliant analytical method. The preset ICH/USP method template, automated J-value calculation, and built-in system suitability reporting eliminated manual configuration steps, making it easier for different analysts to use the instrument. The software also enables method transfer across sites. The demonstrated eight-hour signal stability performance of the 7850 ICP-MS further supports high-throughput batch testing in routine manufacturing QC environments.&nbsp;</p><p>As ICH Q2(R2) provides improved clarity for validating analytical procedures used with peptide based therapeutics, including GLP 1 receptor agonists, this application note provides a regulation-ready reference method. The workflow can be directly adopted or adapted for oral solid dosage forms containing active peptide ingredients, supporting faster regulatory submissions and reducing analytical development timelines.</p><h3><strong>2. Shimadzu: State Analysis of Iron Oxides in Sintered Ore for Steel Manufacturing after Hydrogen Reduction</strong></h3><ul><li>Application note</li><li><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/labrulez-bucket-strapi-h3hsga3/an_01_01029_en_ca7771b317.pdf"><strong>Full PDF for download</strong></a></li></ul><h5><strong>User Benefits</strong></h5><ul><li>The mineral structure of sintered ore can be investigated by quantitative mapping of Al, Mg, Si, Ca, and Fe.&nbsp;</li><li>EPMA analysis is a useful technique in research on the composition of the calcium ferrite phase due to differences in the reduction reaction depending on the furnace temperature.&nbsp;</li><li>Investigation of the oxidation state of iron is useful in study of the production conditions for sintered ore, such as oxidation and reduction.</li></ul><p>Foreign matter in CMP* slurrReduction of carbon dioxide (CO2) emissions is being promoted with the aim of achieving carbon neutrality in 2050. In the hydrogen reduction ironmaking process, iron ore is reduced with hydrogen (H2) in place of coke (C), forming water (H2O) instead of CO2, thereby reducing CO2 emissions. Targeting a reduction of 10 % or more in CO2 emissions, research on a hydrogen reduction technology using hydrogen in the blast furnace is now underway in the Japanese national project COURSE50, focusing on reduction of the heat requirement and optimization of the reaction conditions of the raw materials, together with circulating use of gas with a regenerated reduction capacity, by promoting hydrogen reduction, which is a smaller endothermic reaction than direct reduction by coke. Development of a Super COURSE50 technology has also begun, and will make it possible to inject a larger amount of hydrogen into the blast furnace. This article introduces a state analysis of the iron oxides in sintered ore, which was carried out by measuring the detailed spectra of micro-regions in sintered iron ore after hydrogen reduction using an EPMA electron probe microanalyzer (<strong>EPMA8050G</strong>).</p><h4><strong>Phase Analysis of Sintered Ore after Hydrogen Reduction</strong></h4><p>To identify differences in the oxidation valence, the element distribution images in Fig. 3 show oxygen (O) and iron (Fe) by the mass percentage concentration (wt%) of the simple elements. Fig. 4 (a) and (c) are Fe-O scatter diagrams showing the positions of the compounds by the theoretical concentration of iron oxide under low temperature and high temperature reduction, respectively. In Fig. 4 (a), the symbols 〇 and ▼ represent hematite (Fe2O3) and magnetite (Fe3O4), respectively, while in Fig. 4 (c), clusters (point-sets) can be seen in regions showing ☒ wustite (FeO) and compounds of iron (Fe). Fig. 4 (b) and (d) are phase diagrams in which filters were set by the Fe-O scatter diagrams (see Related Applications 3). In the phase diagrams, the purple regions are hematite, red regions are magnetite, green regions are wustite, dark blue regions are iron, yellow regions are magnesia ferrite, blue regions are calcium ferrite, and yellowgreen regions are slag. The sintered ore contains hematite and magnetite before reduction, but in the reduction reactions at the different furnace temperatures, the species of iron oxides are different depending on the furnace temperature. From the element distribution images and phase diagrams, it can be understood that metallic iron (Fe) has formed in the sintered ore subjected to hydrogen reduction at the high temperature of 1000 ˚C. The light blue region in Fig. 4 (d) is considered to be slag.</p><h4><strong>Conclusion</strong></h4><p>Quantitative mapping analysis and phase analysis of sintered ores after hydrogen reduction can be used not only in identification of iron oxide species and calcium ferrite, but also in structural analysis and research and development of the reduction process by utilizing state analysis from the detailed spectra of micro-regions.&nbsp;</p><h3><strong>3. Thermo Fisher Scientific: Accurate analysis of major components and trace level impurities in cathode active materials used in lithium ion battery production</strong></h3><ul><li>Application note</li><li><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/labrulez-bucket-strapi-h3hsga3/an_003968_analysis_impurities_cathode_active_materials_lithium_ion_battery_production_an003968_na_en_97783566af.pdf"><strong>Full PDF for download</strong></a></li></ul><p>Lithium-ion batteries (LIBs) provide a compact and versatile solution for energy storage, powering everything from consumer electronics to electric vehicles (EVs) and large-scale energy systems. Currently, they are the most important power storage materials for EVs due to their power density and life cycle performance. The performance, longevity, and safety of a battery heavily depends on the purity and the composition of the components, especially the cathode material.&nbsp;</p><p>To meet the required performance criteria (i.e., long battery lifetime and maximum achievable charge capacity), it is important to monitor not only the concentration ratio of the main components (typically nickel, manganese, cobalt, and lithium in nickel manganese cobalt (NMC) batteries), but also trace impurities in both the precursor materials and the finished products. In general, inductively coupled plasma mass spectrometry (ICP-MS) is the preferred analytical technique for the analysis of metals and related contaminants at low levels (sub μg·L-1). However, the analysis of samples containing higher levels of total dissolved solids (TDS, typically above 0.5% weight/volume (w/v)) is a known challenge in ICP-MS. The complexity of the sample matrix can significantly affect the sensitivity of the instrument, cause intensity fluctuation (suppression and drift), and lead to increased system maintenance with unwanted downtime due to clogging of the interface cone orifices, torch injector, or nebulizer. Diluting high matrix samples with argon gas allows direct placement on the autosampler, eliminating the need for manual, time-consuming, off-line dilution.&nbsp;</p><p>A further challenge for the analysis of battery materials such as cathodes when using conventional, single quadrupole ICP-MS is the presence of polyatomic interferences generated by the principal components of the samples. For example, in addition to the well-known argon-based interferences, arsenic can be affected by a cobalt-based interference (59Co16O+). Since arsenic is monoisotopic at m/z 75, removal of this interference is crucial for accurate data. Furthermore, nickel oxide-based interferences can impact the determination of selenium using a single quadrupole ICP-MS system.&nbsp;</p><p>This application note describes an optimized analytical method for the analysis of nickel, manganese, and cobalt (NMC) based cathode materials. To overcome the analytical challenges described above, a triple quadrupole ICP-MS instrument, the <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/products/1488"><strong>Thermo Scientific™ iCAP™ MTX ICP-MS</strong></a>, was employed for the analysis. Use of triple quadrupole technology offered superior interference removal, and operation using Argon Gas Dilution (AGD) facilitated direct analysis of the samples derived from the digestion process. Adverse effects caused by the introduction of high matrix containing samples, such as more frequent maintenance, can also be reduced, thanks to the use of AGD. This enables more efficient laboratory workflow.</p><h4><strong>Conclusion&nbsp;</strong></h4><p>The iCAP MTX ICP-MS enables analysts to perform accurate and reliable elemental analysis in challenging samples such as digested cathode active materials. The proposed analytical method was evaluated for performance, and the results obtained clearly demonstrate the following analytical advantages for battery cathode sample analysis:&nbsp;</p><ul><li>The use of argon gas dilution (AGD) allows the direct analysis of acid digested samples so that labor-intensive manual sample dilutions can be omitted. At the same time, there is no increased need for system maintenance.&nbsp;</li><li>Using oxygen as a reactive gas in TQ-O₂ mode enabled sensitive, interference-free analysis of all analytes, including challenging ones like sulfur and arsenic.&nbsp;</li><li>Excellent CCV recovery and spike recovery results, as well as stable and consistent internal standards response, were obtained, demonstrating the reliability of the method<acknowledgement>The authors wish to express their heartfelt gratitude to Prof. Taichi Murakami of Tohoku University Graduate School of Environmental Studies (GSES) for his generous cooperation in providing the samples and instructions regarding the data analysis in the preparation of this Application News article.</acknowledgement></li></ul>

News from LabRulezICPMS Library - Week 30, 2026

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Since its establishment in 2011, CEITEC has quickly developed into a cutting-edge infrastructure for research which performs highly alongside the best institutes in Europe. Among the main priorities of CEITEC are the promotion of a motivating and dynamic international scientific environment, the provision of state-of-the-art research infrastructure, and the policy of open communication and equal opportunities.

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Mettler-Toledo

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<header><h4><strong>A Guide to Choosing the Optimal Crucible for Your Experiment</strong></h4></header><main><div><div><h5><strong>Program</strong></h5><ul><li>Introduction to thermal analysis crucibles</li><li>DSC crucibles and application examples</li><li>TGA crucibles and application examples</li><li>Tips and hints for selecting the right crucible</li><li>Interactive Q&amp;A session</li></ul></div></div><div><div><div><p>Selecting the right crucible for your application can be a complex process, given the wide range of products available. Making the right choice, however, is essential for obtaining accurate results and protecting your thermal analysis module.</p><p>Using several practical examples for differential scanning calorimetry (<strong>DSC</strong>) and thermogravimetric analysis (<strong>TGA</strong>), this webinar helps you navigate through the many different choices, giving you confidence in your results.</p><p>After the presentation, you will have the opportunity to join the live Q&amp;A session with our experienced METTLER TOLEDO application specialists. &nbsp;</p><p>Want to learn more? Register for our webinar today!</p><h4><strong>Why Using the Right Crucible Is Essential</strong></h4><p>Often, the difference between an accurate and a flawed result has nothing to do with the measuring device, but rather the type of crucible used. For example:</p><ul><li>Crucible material, size, quality, and lids must be carefully selected, according to the application.</li><li>A smooth, flat base is critical to ensure perfect contact with the sample and optimal heat transfer.</li></ul><p>Join our live webinar and discover useful tips and hints on how to select the correct crucible for different types of DSC and TGA applications</p><p><strong>Don’t forget to prepare your questions for the live Q&amp;A with our experts!</strong></p></div><div><div data-advanced-option="false" data-has-preview-image="false" data-video-id="" data-component-id="2110920040"><div style="max-width:1px;width:100%;" id="mediaContainerWrapper_2110920040"><div style="height:1px;width:1px;" data-external-url="" id="mediaContainer_2110920040" data-advanced-option="false" data-width="1" data-height="1" data-video-id="">&nbsp;</div></div></div></div></div></div></main><div><div><div data-advanced-option="false" data-has-preview-image="false" data-video-id="" data-component-id="2110920040"><blockquote><div><strong>Presenter: </strong>Angela Hammer (Dr. sc. nat. ETH)</div><p>Dr. Angela Hammer received a Ph.D. in Analytical Chemistry (development of immobilized components for the use in ion-selective electrodes based on polyurethane membranes) from the Institute of Organic Chemistry at the Swiss Federal Institute of Technology in Zürich, Switzerland. She then joined Sika Technology AG in Zurich, Switzerland, as an analytical chemist. In 2007, she joined METTLER TOLEDO and has worked there since as an application specialist for Thermal Analysis. In her present position, she uses, teaches, and supports DSC, TGA, TMA, and DMA instruments for the METTLER TOLEDO’s Materials Characterization Group located at the head office in Switzerland.</p></blockquote></div></div></div>

Mettler Toledo: Crucible Selection for Thermal Analysis

Crucible Selection for Thermal Analysis

Join our live webinar and discover useful tips and hints on how to select the correct crucible for different types of DSC and TGA applications

<p><strong>Accurate elemental analysis supports confident decisions across metal production, inspection, and verification workflows. When results are required directly at the worksite, analytical performance must remain consistent despite changing conditions, time pressure, and diverse alloy types. Optical emission spectroscopy enables fast, information‑rich metals analysis, including the measurement of critical light elements that influence material properties and compliance.</strong></p><p>This live webinar explains how modern metal analysis workflows benefit from portable OES‑based approaches. The session describes how on‑site measurements support alloy identification, grade verification, and pass/fail decisions while reducing delays caused by laboratory transport and sample preparation. The presentation also discusses how elemental analysis with LIBS technology complements established metal analysis techniques such as ICP‑OES and ED‑XRF by extending elemental coverage directly into the field.</p><p>In the final part of the webinar, we´ll introduce the SPECTROPORT LIBS, a portable laser‑induced breakdown spectroscopy analyzer designed to deliver reliable OES performance outside the laboratory. The system applies advanced LIBS technology to support fast, application‑focused elemental analysis where immediate results matter most.</p><h5><strong>Key takeaways include:</strong></h5><ul><li>How portable OES supports confident elemental analysis of metals in field and production environments</li><li>Why LIBS‑based metal analysis extends elemental coverage beyond handheld XRF limitations</li><li>How application‑driven workflows improve decision‑making speed without sacrificing analytical reliability</li></ul><h4><strong>Join us live:</strong></h4><ul><li>10:30 AM CEST (Berlin); 4:30 PM SGT (Singapore) — Time Slot 1</li><li>11:00 AM EDT (New York); 5:00 PM CEST (Berlin) — Time Slot 2</li></ul><blockquote><p><strong>Presenter:</strong> Marcus Freit</p><p>Marcus Freit is Product Manager for mobile and stationary metal analyzers at SPECTRO Analytical Instruments. He oversees the strategic development of the entire product portfolio, including application development and product support. With 35 years at SPECTRO and extensive experience in various roles, Marcus has been shaping product strategy as Product Manager since 2002.</p></blockquote>

SPECTRO / AMETEK: Introducing SPECTROPORT LIBS — Reliable On‑Site Metal Identification

Introducing SPECTROPORT LIBS — Reliable On‑Site Metal Identification

Discover how portable OES and LIBS improve on-site metal analysis, alloy identification, and elemental testing with fast, reliable results.

SPECTROPORT LIBS On‑Site Metal Identification

<p><strong>Modern coordination chemistry can control various material properties—such as structure, reactivity, color, magnetism, catalytic function and many more—through metal complexes. The understanding of how the metals interact with surrounding molecules or ions often is in the focus of the research. To analyze aspects like the metal coordination number, geometry, ligand binding modes, and metal–ligand bond lengths and angles Single Crystal X-ray Diffraction (SC-XRD) is invaluable, as it provides a clear three-dimensional model of the complex, unlike many other techniques.</strong></p><p>Join our webinar to learn how your research can benefit from Bruker’s latest innovations in SC-XRD. Along a number of examples, we will demonstrate the benefits of advanced X-ray diffraction technology. We will show how modern instrumentation helps to address challenges typical in coordination chemistry and to deliver the precision needed for accurate 3D structure determination in modern crystallography.</p><h4><strong>Who should attend?</strong></h4><ul><li>Coordination chemists interested in unambiguous 3-D structure determination</li><li>Crystallographers looking to implement the latest state-of -the-art technology into their X-ray facility</li><li>Anyone interested in the advanced X-ray technology for structure determination&nbsp;</li></ul><h4><strong>Which topics will be covered?</strong></h4><ul><li>Coordination Chemistry and Metal-Organic Frameworks – Challenges in structure determination</li><li>How Coordination Chemistry Benefits from single crystal structure determination</li><li>Technical Advances on SC-XRD hardware and software</li><li>The right wavelength for the right crystal</li><li>Better data - faster</li></ul><blockquote><p><strong>Speaker: </strong>Dr. Martin Adam (SC-XRD Product Manager, Bruker AXS)</p></blockquote>

Bruker: Advancing Coordination Chemistry with Single Crystal X-ray Diffraction

Advancing Coordination Chemistry with Single Crystal X-ray Diffraction

Join our webinar to learn how your research can benefit from Bruker’s latest innovations in SC-XRD.

Coordination Chemistry with Single Crystal X-ray Diffraction

<p><strong>Ultra‑trace impurity analysis is increasingly required for high‑purity reagents used in semiconductor processing and other advanced materials applications, where chemicals such as nitric and sulfuric acids must meet stringent contamination specifications. Analytical methods for these reagents must achieve sub‑ppt level detection limits (DLs) while maintaining low instrumental backgrounds under hot‑plasma conditions. This study describes a triple quadrupole Inductively Coupled Plasma Mass Spectrometry (ICP QQQ) workflow for the ultra trace analysis of high purity reagents using preset analytical methods optimized for low matrix samples.</strong></p><blockquote><p><strong>Presenter:</strong> Bert Woods (Application Scientist, Agilent Technologies, Inc.)</p><p>Joined the Agilent ICP-MS team in 2004, with previous employment in the semiconductor industry with Dominion Semiconductor (IBM/Toshiba) and Micron. Bert is a 1997 Chemistry graduate of Radford University in Virginia and an avid Washington DC Sports fan.</p></blockquote>

Agilent Technologies: Atomic Spectroscopic webinars

Ultra Trace Analysis of High-Purity Reagents by 9500 ICP-QQQ with m-lens

ICP QQQ workflow for sub-ppt ultra-trace impurity analysis of high-purity acids and reagents used in semiconductor processing.

Trace Analysis of Reagents by 9500 ICP-QQQ

<p><strong>The Indian pharmaceutical industry is constantly seeking faster, more efficient ways to ensure product quality while reducing testing time and operational costs. Traditional methods such as HPLC are highly effective but can be time-consuming and require extensive sample preparation.</strong></p><p>Join this webinar to discover how the Agilent TRS100 Quantitative Pharmaceutical Analysis System uses Transmission Raman Spectroscopy to provide rapid, non-destructive analysis of intact tablets and capsules. Learn how TRS100 enables fast content uniformity testing, assay, identification, and solid-state analysis with minimal sample handling, helping laboratories improve throughput and accelerate decision-making.</p><h4><strong>Why Attend?</strong></h4><ul><li>Learn how to perform rapid content uniformity testing on intact tablets and capsules.</li><li>Reduce analysis time and eliminate sample preparation.</li><li>Increase laboratory productivity while reducing solvent and consumable use.</li><li>Explore applications in assay, identification, polymorph, and crystallinity analysis.</li><li>Understand how TRS complements existing HPLC workflows in pharmaceutical QC.</li></ul><h4><strong>Who Should Attend?</strong></h4><ul><li>QC and QA Managers</li><li>Analytical and Pharmaceutical Scientists</li><li>Formulation and R&amp;D Scientists</li><li>Manufacturing and Process Development Teams</li><li>Regulatory and Compliance Professionals</li></ul><h4><strong>What You Will Learn</strong></h4><ul><li>Fundamentals of Transmission Raman Spectroscopy</li><li>How the Agilent TRS100 performs whole-tablet analysis</li><li>Applications in content uniformity and solid-state characterization</li><li>Benefits of implementing rapid, non-destructive testing in pharmaceutical laboratories</li></ul><p>Join us to see how the Agilent TRS100 is helping pharmaceutical laboratories in India accelerate quality control while maintaining confidence in analytical results.</p><blockquote><p><strong>Speaker:</strong> Sounik Saha (Dr., Dr. Reddy’s Laboratories, India)</p><p>Dr. Sounik Saha, PhD, is a Material Science Expert and analytical R&amp;D leader at Dr. Reddy’s Laboratories, India with extensive experience in advanced material characterization.</p><p>He completed his PhD from the Indian Institute of Science, Bangalore in 2011, followed by postdoctoral research at internationally renowned institutions including UT Southwestern Medical Center, Dallas, USA, and Mayo Clinic, Rochester, USA. He joined Dr. Reddy’s Laboratories in 2015 as part of the Advanced Characterization Technology Laboratory, where he has contributed significantly to strengthening advanced analytical capabilities for complex pharmaceutical product development. He led the Analytical Material Sciences Team at Novartis, India from 2021 to 2025 before joining back at Dr. Reddy’s Laboratories.</p><p>Dr. Saha specializes in state-of-the-art spectroscopic and microscopic characterization techniques and plays a key role in designing robust analytical strategies for complex generic product development. He has been instrumental in implementing Near-Infrared Spectroscopy and Transmission Raman Spectroscopy-based PAT initiatives across R&amp;D and manufacturing at Dr. Reddy’s Laboratories, contributing to successful regulatory filings and approvals for multiple high-value oral solid dosage products.</p><p>His work effectively bridges advanced materials science, analytical innovation, regulatory expectations, and practical product development outcomes.</p><p>Title of talk “Non-Destructive Analytical Technologies as Alternatives to Conventional approaches: Regulatory Expectations and Practical Insights”</p></blockquote><blockquote><p><strong>Speaker:</strong> Ms. Vijaya Jyothi (Product Specialist - Spectroscopy, Agilent Technologies India Pvt. Ltd.)</p><p>Vijaya Jyothi is a seasoned product specialist at Agilent Technologies. She manages the spectroscopy division, having extensive expertise in spectroscopy applications across diverse industries, offering deep insights and solutions tailored to varied analytical needs.</p></blockquote>

Agilent Technologies: Fast, Non-Destructive Pharmaceutical Analysis with the Agilent TRS100

Fast, Non-Destructive Pharmaceutical Analysis with the Agilent TRS100

Optimize pharmaceutical QC with the Agilent TRS100. Replace tedious sample prep with rapid, non-destructive analysis of whole tablets and capsules

Rapid Non-Destructive Pharma Analysis: Agilent TRS100

<div><h4><strong>Unlock the Power of Full-Spectrum Flow Cytometry</strong></h4><p><strong>A two-part masterclass designed to help you understand, design, and apply high-dimensional flow cytometry workflows across immunology, oncology, and vaccine research.</strong></p><h5><strong>Session 2: Designing and Analysis of Spectral Flow Experiments</strong></h5><ul><li><strong>Key Advantages of Spectral Technology. </strong>Learn how spectral systems enable higher multiplexing, improved resolution, and enhanced flexibility in panel design for complex experiments.</li><li><strong>Workflow of Spectral Flow Cytometry. </strong>Step through the complete experimental journey—from panel design and sample preparation to acquisition and interpretation of high-dimensional data.</li><li><strong>Unmixing and Data Analysis Strategies. </strong>Gain insights into spectral unmixing principles and advanced analytical approaches that transform raw data into meaningful biological interpretation.</li></ul><h5><strong>Why Attend?</strong></h5><ul><li>Move beyond conventional flow limitations</li><li>Design high-dimensional experiments confidently</li><li>Learn real-world applications</li><li>Interact with flow cytometry experts</li></ul><blockquote><p><strong>Presenter:</strong> Dr. Hemant Agrawal (Director, Flowcytometry Solutions Pvt. Ltd., India)</p><p>Flow cytometry educationalist and global trainer with 15+ years of experience. Conducted 80+ onsite and 40+ online workshops worldwide. An active member of ISAC (International Society for Advancement of Cytometry) task forces, Dr. Agrawal is widely recognized for advancing cytometry education globally and has been an invited faculty at prestigious Indo-US Cytometry Workshops.</p></blockquote><blockquote><p><strong>Presenter:</strong> Dr. Saket Siddharth (Field Application Scientist – Flowcytometry, Agilent Technologies)</p><p>Saket Siddharth is a Flow Cytometry and Cell Analysis specialist with over nine years of experience spanning clinical cytometry, spectral cell sorting, and advanced multicolor panel design. He holds a Ph.D. from the Helmholtz Centre for Infection Research, Brunswick, Germany, and has developed strong expertise across antibody development, high-throughput screening, and assay validation for translational and research applications.</p></blockquote></div>

Agilent Technologies: Spectral Flow Cytometry Masterclass - Session 2

Spectral Flow Cytometry Masterclass - Session 2

Learn high-dimensional spectral flow cytometry workflows with Cytek. Master panel design, sample prep, and advanced spectral unmixing strategies

Spectral Flow Cytometry Masterclass

<p><strong>As materials become increasingly sophisticated, understanding their optical properties is essential for driving innovation, improving product performance, and ensuring quality. Whether developing anti-reflective coatings, optimising solar cell efficiency, designing specialty glass, or researching next-generation materials, accurate optical characterisation is a critical part of the workflow.</strong></p><p>Join us for this webinar to discover how the Agilent UV-Vis-NIR spectrophotometer enables researchers and industry professionals to measure and characterise a broad range of optical properties across diverse sample types and applications.</p><p>The webinar will showcase measurement techniques for transmission, reflectance, diffuse reflectance, and angular measurements, highlighting how the Agilent UV-Vis-NIR platform delivers reliable and reproducible data for both research and industrial applications.</p><h4><strong>Why Attend?</strong></h4><p><strong>In this session, you will learn:</strong></p><ul><li>How the Agilent UV-Vis-NIR can be used to characterise thin films, coatings, solar materials, and glass.</li><li>Techniques for measuring transmission, reflectance, and diffuse reflectance with confidence.</li><li>Methods for determining film thickness and evaluating optical performance.</li><li>How specialised accessories expand measurement capabilities for challenging samples.</li><li>Best practices for obtaining accurate, reproducible results across a variety of applications.</li><li>Real-world examples demonstrating how optical measurements can accelerate research and product development.</li></ul><h4><strong>Who Should Attend?</strong></h4><p><strong>This webinar is designed for:</strong></p><ul><li><strong>Academic Researchers and Students</strong><ul><li>Researchers in materials science, physics, chemistry, and engineering.</li><li>Scientists investigating thin films, nanomaterials, optical materials, and photonic devices.</li><li>Graduate students and postdoctoral researchers seeking advanced optical characterisation techniques.</li></ul></li><li><strong>Solar and Photovoltaics</strong><ul><li>Scientists and engineers developing solar cells and photovoltaic materials.</li><li>Researchers evaluating anti-reflective coatings and light management strategies.</li><li>Teams working to improve solar cell efficiency through optical optimisation.</li></ul></li><li><strong>Glass and Coatings Industries</strong><ul><li>Manufacturers of architectural, automotive, and specialty glass.</li><li>Researchers developing low-emissivity and anti-reflective coatings.</li><li>Quality control and R&amp;D professionals responsible for optical performance testing.</li></ul></li><li><strong>Advanced Materials and Industrial R&amp;D</strong><ul><li>Thin film and semiconductor researchers.</li><li>Optical coating manufacturers.</li><li>Scientists working with displays, sensors, filters, and advanced functional materials.</li><li>Analytical laboratories requiring precise optical characterisation.</li></ul></li></ul><h5><strong>Featured Applications</strong></h5><ul><li>Thin film and multilayer coating analysis</li><li>Anti-reflective and optical coating characterisation</li><li>Solar cell and photovoltaic material evaluation</li><li>Optical filter transmission and blocking measurements</li><li>Architectural and specialty glass analysis</li><li>Reflectance measurements at varying angles of incidence</li><li>Film thickness determination</li><li>Diffuse reflectance measurements of scattering materials</li><li>Optical characterisation of emerging materials in academia and industry</li></ul><p>Discover how the Agilent UV-Vis-NIR platform combines exceptional optical performance, flexible sampling accessories, and intuitive workflows to provide the insights needed to advance research, optimise products, and solve challenging analytical problems.</p><blockquote><p><strong>Presenter: </strong>Mr. Rajwar Chandra (Product Specialist - Spectroscopy, Agilent Technologies)</p><p>Chandra Rajwar is a Product &amp; Market Specialist with over 20 years of experience in Molecular Spectroscopy products and analytical instrumentation. He specializes in UV-Vis, FTIR, Raman, and related spectroscopy solutions, supporting customers with application development, workflow optimization, and analytical excellence across pharmaceutical, chemical, environmental, and research industries.</p></blockquote><blockquote><p><strong>Presenter: </strong>Ms. Vijaya Jyothi (Product Specialist - Spectroscopy, Agilent Technologies India Pvt. Ltd.)</p><p>Vijaya Jyothi is a seasoned product specialist at Agilent Technologies. She manages the spectroscopy division, having extensive expertise in spectroscopy applications across diverse industries, offering deep insights and solutions tailored to varied analytical needs.</p></blockquote>

Agilent Technologies: Characterising Advanced Materials with the Agilent UV-Vis-NIR - From Thin Films and Solar Cells to Glass and Optical Coatings

Characterising Advanced Materials with the Agilent UV-Vis-NIR: From Thin Films and Solar Cells to Glass and Optical Coatings

Characterize thin films, solar cells, and coatings with Agilent UV-Vis-NIR. Master reflectance, transmission, and angular measurement workflows

Materials Characterization with Agilent UV-Vis-NIR

<h4><strong>Atomic Webinar Series</strong></h4><p><strong>Ensuring food safety requires accurate detection of toxic elements at very low concentration levels, as mandated by international standards such as AOAC Official Method 2015.01. Food matrices pose significant analytical challenges because of their complex compositions, high dissolved solids after digestion, and spectral interferences, including polyatomic and doubly charged rare-earth element species. Simultaneously, food testing laboratories need high sample throughput and minimal operator intervention. This study presents an automated ICP-MS/MS workflow for multi-element analysis of various food matrices using discrete sampling and intelligent autodilution.</strong></p><blockquote><p><strong>Presenter:</strong> Jeff Sayen (ICP-MS Application Scientist, Agilent Technologies)</p><p>Jeffrey Sayen s an ICP-MS Application Scientist at Agilent Technologies with over 15 years of experience in analytical chemistry. He specializes in atomic spectroscopy techniques, including ICP-MS, ICP-OES, and Flame AA. Jeffrey is passionate about ICP-MS and enjoys delivering product and application overviews at customer sites, seminars, and industry events. Prior to joining Agilent, he held the position of Senior Field Application Scientist at another major instrument manufacturer, where he focused on analytical methodologies across a range of regulated industries. He holds both undergraduate and graduate degrees in Inorganic Chemistry from Michigan State University.</p></blockquote>

Agilent Technologies: Atomic Spectroscopy Webinar Series - Elemental Analysis of Foods by Agilent 9500 ICP-QQQ with an Autodilutor

Elemental Analysis of Foods by Agilent 9500 ICP-QQQ with an Autodilutor

Optimize food analysis with the Agilent 9500 ICP-QQQ. Learn how intelligent autodilution resolves interferences and boosts laboratory throughput

Food Elemental Analysis with Agilent 9500 ICP-QQQ

<p><strong>This webinar provides an overview of the Advanced Dilution System (ADS 2), including its operating principles and key parameters for optimization. Troubleshooting approaches will be discussed, with an emphasis on resolving timing, carryover, and precision-related challenges.</strong></p><blockquote><p><strong>Presenter:</strong> Ana García González (Atomic Spectroscopy Application Scientist, Agilent Technologies)</p><p>Ana Garcia is the Atomic Spectroscopy Application Scientist at Agilent Technologies. Ana has a broad background in atomic spectroscopy technologies, including international experience developing and validating analytical spectroscopy methods for the geochemical industry. She has also published in the fields of molecular spectroscopy and chemometrics. Ana holds a MSc in plant Biotechnology at CINVESTAV, México, and a Bachelor of Science in Biotechnology Engineering.</p></blockquote>

Agilent Technologies: Optimizing ADS 2 Autodilutor

Optimizing ADS 2 Autodilutor: Operation, Troubleshooting, & Best Practices

Master the Agilent ADS 2 autodilutor. Learn troubleshooting strategies for timing, carryover, and precision challenges to optimize your workflow

Optimizing the ADS 2 Autodilutor: Troubleshooting

<div><div id="inner_content_body_text" data-content-id="394785"><p><strong>The essential techniques used to characterize heterogeneous catalysts have remained largely unchanged for decades. This is especially true when it comes to automation, ease of use, repeatability, reproducibility, and operator safety.</strong></p><p>In this webinar, we will present Anton Paar’s <strong>Autosorb 3300</strong> and the latest developments in temperature-programmed measurements, including <strong>TPR, TPO, and TPD</strong>, as well as pulse titration for active metal area. The session will highlight innovations such as liquid-cooled high-temperature furnace design, automatic leak detection, linear heating, automatic injection loop selection, and simplified sample cell attachment.</p><p>Learn how Autosorb 3300 helps reduce the complexity of chemisorption and makes advanced catalyst characterization more accessible to laboratories in industry and academia while supporting high-quality data. The presentation will also include practical examples of different measurement types.</p><blockquote><p><strong>Presenter:</strong> Dr. Martin A. Thomas PhD</p><p>Dr Thomas has more than 40 years’ experience in porous materials characterization, much of that time associated with heterogeneous catalysts as well as battery materials, ceramics and pharmaceuticals. He joined Quantachrome Instruments in 1991 from ICI’s Catalyst Research Centre in the UK, and has served as Anton Paar QuantaTec’s Lead Scientist since 2020, supporting customers worldwide through webinars and seminars. He is co-author of the book “Characterization of Porous Solids and Powders: Surface Area, Pore Size and Density” published by Springer.</p></blockquote></div></div>

Anton Paar: Next-Generation Flow Chemisorption with Autosorb 3300

Next-Generation Flow Chemisorption with Autosorb 3300

How Autosorb 3300 helps reduce the complexity of chemisorption and makes advanced catalyst characterization more accessible to laboratories

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