🎤Monique MelloIn this episode of Concentrating on Chromatography, David sits down with Monique Mello, analytical chemist, educator, and LA-ICP-MS imaging specialist, to explore how laser ablation ICP-MS (LA-ICP-MS) and immuno-mass spectrometry imaging (iMSI) are transforming pathology, environmental science, and translational research.Monique shares her journey from public-health and pathology labs in Brazil to environmental and biomedical research in Australia — and explains why metrology, traceability, and defensible measurements are the foundation of meaningful science.We dive into her work developing multiplexed elemental imaging methods that allow researchers to quantify multiple proteins at once in tissue — revealing interactions that traditional single-marker methods miss. Her studies show how LA-ICP-MS can map dystrophin-glycoprotein complex proteins in muscular dystrophy and track elemental distributions like zinc in Alzheimer’s disease tissue.We also discuss something many labs overlook: sample preparation and immunolabelling can change the chemistry you’re trying to measure. Monique’s research demonstrates how staining steps can redistribute endogenous metals and why rigorous validation is critical for trustworthy data.If you care about chromatography, mass spectrometry, or analytical chemistry that genuinely impacts patients and communities, this episode is for you.<h5>In this conversation, we cover:</h5><ul><li>What LA-ICP-MS imaging is and how it works</li><li>Multiplexed antibody tagging with lanthanides for quantitative tissue imaging</li><li>Why metrology and uncertainty matter more than “pretty data”</li><li>Common analytical failures (and why sample prep causes most of them)</li><li>Elemental mapping in muscular dystrophy and Alzheimer’s research</li><li>How immunolabelling and coverslipping can perturb endogenous metals</li><li>Teaching analytical chemistry for real-world problem solving</li></ul><h3>Video Transcription</h3>Analytical chemistry sits at the intersection of science, decision-making, and trust. Whether applied in environmental monitoring, clinical research, or biological imaging, the reliability of analytical results determines how confidently we can interpret data and act on it.In a recent expert discussion, key themes emerged that resonate strongly across the analytical community—from the fundamentals of metrology to advanced techniques such as laser ablation ICP-MS (LA-ICP-MS). This article highlights the most important insights for scientists working with complex matrices, trace analysis, and high-impact data.<h4>Analytical Chemistry: Evidence Over Opinion</h4>At its core, analytical chemistry is about transforming observations into defensible, quantitative evidence. The use of calibrated methods—such as properly constructed calibration curves—ensures that measured values reflect reality as closely as possible.Reliable data is not just a technical outcome; it is a responsibility. Every result must be:<ul><li>Traceable</li><li>Accurate</li><li>Interpretable</li><li>Fit for decision-making</li></ul>When methods are robust, the sample itself “tells the truth.” The challenge lies in ensuring that nothing in the workflow distorts that message.<h4>Metrology: The Invisible Backbone of Data Quality</h4>Despite its importance, metrology is often overlooked outside specialized laboratories. This is largely because it operates silently—until something goes wrong.Several factors contribute to its underappreciation:<ul><li>Focus on novelty over measurement quality Scientific recognition often prioritizes new findings rather than data reliability.</li><li>Black-box instrumentation Modern instruments appear “plug-and-play,” leading to overconfidence in automatically generated results.</li><li>Confusion between precision and accuracy Repeatability does not guarantee correctness.</li><li>Complexity of uncertainty Concepts like uncertainty budgets and traceability are perceived as abstract or overly statistical.</li><li>Time and cost pressures Proper validation, use of certified reference materials (CRMs), and quality control require additional resources.</li></ul>Improving metrology awareness requires translating these concepts into practical laboratory workflows and emphasizing their direct impact on scientific conclusions.<h4>Where Analytical Methods Most Commonly Fail</h4>Failures in analytical workflows typically originate upstream—well before data processing or interpretation.<h5>1. Sample Preparation (Primary Source of Error)</h5>The majority of analytical errors arise during sample preparation, including:<ul><li>Contamination (reagents, labware, environment)</li><li>Poor recovery (adsorption, volatilization, filtration losses)</li><li>Matrix effects</li><li>Non-representative sampling</li><li>Lack of proper controls</li></ul>Errors introduced here propagate through the entire analytical chain.<h5>2. Data Interpretation</h5>Common issues include:<ul><li>Misuse or misunderstanding of calibration models</li><li>Ignoring instrumental drift</li><li>Overreliance on linearity without validation</li></ul><h5>3. Instrumentation</h5>Although often blamed, instruments are less frequently the root cause. Still, issues such as:<ul><li>Detector saturation</li><li>Carryover</li><li>Misalignment</li><li>Signal drift can significantly impact results.</li></ul><h5>Best Practices for Reliable and Defensible Data</h5>For early-career scientists and experienced analysts alike, several habits are essential:<ul><li>Document everything (lab notebooks, timestamps, workflows)</li><li>Standardize sample preparation procedures</li><li>Use quality controls (blanks, spikes, duplicates, CRMs)</li><li>Validate before analyzing samples</li><li>Avoid reusing calibration curves</li><li>Preserve raw data securely</li><li>Evaluate uncertainty and detection limits</li></ul>Strong documentation and consistent QC transform data from “results” into defensible evidence.<h4>LA-ICP-MS: A Powerful Tool for Biological Imaging</h4>Laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS) represents a significant advancement in analytical capabilities—particularly for spatially resolved analysis.<h5>Key Advantages</h5><ul><li>Direct analysis of solid samples (no digestion required)</li><li>Preservation of spatial information</li><li>Simultaneous multi-element detection</li><li>Quantitative imaging of biological tissues</li></ul>In biological applications, LA-ICP-MS enables researchers to:<ul><li>Map the distribution of biomolecules or metals in tissues</li><li>Study interactions in situ</li><li>Combine spatial and quantitative information</li></ul>For example, multiplex imaging allows simultaneous observation of multiple targets, providing a more realistic representation of biological systems compared to single-marker approaches.<h4>Multiplex Imaging vs. Single-Marker Analysis</h4>Traditional methods often focus on one analyte at a time. However, biological systems are inherently complex and interactive.Multiplex approaches enable:<ul><li>Co-localization analysis</li><li>Detection of interactions between biomolecules</li><li>Identification of spatial heterogeneity</li></ul>This is particularly critical in disease research, where:<ul><li>Single-marker data may lead to misleading conclusions</li><li>Multi-target analysis reveals underlying biological mechanisms</li></ul><h4>Applications in Disease Research: The Case of Metal Distribution</h4>In neurodegenerative diseases such as Alzheimer’s, total elemental concentration alone is insufficient.For example:<ul><li>Zinc may be present at similar total levels in healthy and diseased tissue</li><li>However, its spatial distribution changes significantly, forming localized clusters</li></ul>Elemental mapping therefore provides:<ul><li>Insight into disease progression</li><li>Potential diagnostic markers</li><li>Support for targeted therapeutic strategies</li></ul><h4>Lessons from Environmental Analysis</h4>Environmental chemistry offers valuable principles applicable across analytical disciplines:<ul><li>Treat complex matrices with caution</li><li>Control contamination rigorously</li><li>Ensure representative sampling</li><li>Validate methods with appropriate standards</li></ul><blockquote>One key takeaway: A linear calibration curve does not guarantee accuracy—traceability does.</blockquote><h4>Sample Preparation: The Most Underrated Investment</h4>Laboratories often prioritize instrumentation over sample preparation, but this is a critical imbalance.Key recommendations:<ul><li>Treat sample preparation as part of the analytical system</li><li>Invest in method development and training</li><li>Routinely verify performance (blanks, drift, recovery)</li><li>Maintain strict adherence to SOPs</li></ul>Poor sample preparation cannot be corrected downstream—even with the most advanced instrumentation.<h4>Scientific Continuity and Data Integrity</h4>A less-discussed challenge in analytical science is the loss of continuity:<ul><li>Staff turnover</li><li>Incomplete documentation</li><li>Fragmented datasets</li></ul>This leads to:<ul><li>Repetition of work</li><li>Loss of knowledge</li><li>Reduced reproducibility</li></ul>Robust documentation and standardized workflows are essential to ensure that research progress is cumulative rather than cyclical.<h4>Mindset for the Next Generation of Analytical Scientists</h4>To produce impactful and trustworthy work, scientists should adopt the following principles:<ul><li>Resilience – experiments fail; learning continues</li><li>Critical thinking – understand every step, not just follow protocols</li><li>Curiosity – always ask “why”</li><li>Impact awareness – consider who benefits from your data</li><li>Respect for fundamentals – QC, documentation, and preparation matter most</li></ul>Analytical chemistry is not just about generating numbers—it is about generating truth.<h4>Conclusion</h4>From metrology and sample preparation to advanced imaging techniques like LA-ICP-MS, the strength of analytical science lies in its ability to produce reliable, interpretable, and actionable data.As analytical challenges grow more complex—especially in fields such as biomedicine and environmental science—the need for robust methodologies and critical thinking becomes even more essential.Ultimately, the value of analytical chemistry is measured not only by precision, but by the confidence we place in the decisions it enables.<blockquote>This text has been automatically transcribed from a video presentation using AI technology. It may contain inaccuracies and is not guaranteed to be 100% correct.</blockquote><blockquote><h4>Concentrating on Chromatography Podcast</h4>Dive into the frontiers of chromatography, mass spectrometry, and sample preparation with host David Oliva. Each episode features candid conversations with leading researchers, industry innovators, and passionate scientists who are shaping the future of analytical chemistry. From decoding PFAS detection challenges to exploring the latest in AI-assisted liquid chromatography, this show uncovers practical workflows, sustainability breakthroughs, and the real-world impact of separation science. Whether you’re a chromatographer, lab professional, or researcher you'll discover inspiring content!You can find Concentrating on Chromatography Podcast in podcast apps:<ul><li><a target="_blank" rel="noopener noreferrer" href="https://open.spotify.com/show/1wZg67rCjoGju4yhqxI3tL">Spotify</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://podcasts.apple.com/tz/podcast/concentrating-on-chromatography/id1788429185">Apple podcast</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://podscan.fm/podcasts/concentrating-on-chromatography">podscan</a></li></ul>and on <a target="_blank" rel="noopener noreferrer" href="https://www.youtube.com/@ChromatographyTalk/videos">YouTube channel</a></blockquote>

How LA-ICP-MS Imaging Reveals Disease in Tissue

Optical Extraction of Single Microplastics Followed by Online Molecular and Elemental Characterization

In the week from May 4, the following webinars await you in the field of atomic and molecular spectroscopy and spectrometry<blockquote><h4><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/webinars">👉 DETAILS AND REGISTRATION IN THE WEBINARS SECTION</a></h4>👉 Search and filter in the largest global database with over 5 500 GC, LC, MS and spectroscopy webinars.</blockquote><h5>1. Thermo Fisher Scientific: Unlocking standardless X-ray fluorescence analysis with Thermo Scientific™ UniQuant™ Software</h5><ul><li>Tu, 5.5.2026 14:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/webinar/6161">Registration</a></li></ul>Learn how standardless XRF with UniQuant software delivers accurate results without calibration standards, combining advanced instrumentation with optimized sample preparation.<h5>2. AZoM: Organic Contamination Analysis: A FIB-FTIR Workflow</h5><ul><li>Tu, 5.5.2026 17:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/webinar/6143">Registration</a></li></ul>Organic contamination presents a persistent challenge across industries, particularly when particles are small, embedded, or difficult to isolate.<h5>3. Agilent Technologies: High-Throughput ICP-OES Analysis of Elements in Brines from Direct Lithium Extraction</h5><ul><li>Tu, 5.5.2026 20:30 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/webinar/6062">Registration</a></li></ul>Discover how ICP-OES with advanced dilution enables accurate elemental analysis of complex lithium brines in Direct Lithium Extraction workflows, supporting robust quality control.<h5>4. Milestone: Heavy Metals in Food: Digestion Strategies and Complete Sample Prep Workflow</h5><ul><li>We, 6.5.2026 16:00 CET</li><li><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/webinar/5821">Registration</a></li></ul>This webinar covers best practices for microwave digestion of diverse food matrices using systems such as ETHOS and ultraWAVE 2 eco.<h5>5. Bruker: PHOTON IV: Learn How Unique Detector Technology is Driving Modern Crystallography</h5><ul><li>We, 6.5.2026 17:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/webinar/6162">Registration</a></li></ul>Join our webinar to learn how Bruker AXS’s PHOTON IV X-ray detectors combine advanced active pixel sensor technology and innovative readout methods.<h5>6. AZoM: Unlocking Material Insights with Raman Spectroscopy: From Fundamentals to Real-World Applications</h5><ul><li>Th, 7.5.2026 16:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/webinar/6163">Registration</a></li></ul>Discover how Raman spectroscopy enables fast, non-destructive chemical analysis, with advanced imaging and microscopy for material identification and research workflows.<h5>7. C&amp;EN: Smarter Materials Qualification in a Changing Supply Chain</h5><ul><li>Th, 7.5.2026 17:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/webinar/6164">Registration</a></li></ul>This webinar explores how FTIR spectroscopy can help laboratories detect variability, validate materials with confidence, and reduce risk in supplier qualification.<h5>8. Agilent Technologies: A Workshop on Substrates and Software tools for Microplastics Analysis using the LDIR</h5><ul><li>Th, 7.5.2026 19:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/webinar/6050">Registration</a></li></ul>This workshop will review the different substrates used for microplastics analysis and will focus on best practices for sample measurement and software functions.<h5>9. Agilent Technologies: Getting Elemental Impurity Testing Right: Preparing for upcoming regulatory changes with Advanced Analytical Workflows</h5><ul><li>Fr, 8.5.2026 07:30 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/webinar/6167">Registration</a></li></ul>Prepare for IP 5.10 elemental impurity regulations with ICP-MS workflows, risk-based strategies, and global alignment across USP, EP, and ICH Q3D.

Webinars LabRulezICPMS Week 19/2026

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Organomation, founded in 1959, designs and manufactures high-quality nitrogen evaporators and extraction systems. Known for innovation and durability, their lab instruments are used globally for efficient sample preparation with strong customer support.

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<h4>Food &amp; Feed Sample Preparation Webinar Series</h4>Ensuring food and feed quality requires reliable determination of both contaminants and nutrients, yet sample preparation remains one of the most challenging and time-consuming steps in the analytical workflow. This webinar series introduces modern approaches to digestion and extraction that improve data quality, reduce reprocessing, and increase laboratory productivity. Through four dedicated events, covering heavy metals, organic contaminants, macro/trace minerals, and nutritional parameters such as fats, FAMEs, and amino acids, participants will discover optimized, practical workflows tailored to real-world food and feed testing.<h4>Session: Heavy Metals in Food: Digestion Strategies and Complete Sample Prep Workflow</h4>Heavy metals such as Pb, Cd, As, and Hg are strictly regulated in food and feed, requiring robust digestion and a well-controlled sample preparation workflow. This webinar covers best practices for microwave digestion of diverse food matrices using systems such as ETHOS and ultraWAVE 2 eco. A case study on baby food will illustrate common challenges such as matrix complexity, contamination control, and blank management. Participants will learn how to build a reliable sample-to-analysis workflow that ensures accuracy, reduces re-runs, and supports regulatory compliance.<blockquote>Speaker: Giulio Colnaghi (Marketing Manager, Milestone Srl)</blockquote>

Milestone: Food & Feed Sample Preparation Webinar Series

Heavy Metals in Food: Digestion Strategies and Complete Sample Prep Workflow

This webinar covers best practices for microwave digestion of diverse food matrices using systems such as ETHOS and ultraWAVE 2 eco. 

Digestion Strategies and Complete Sample Prep Workflow

This workshop will review the different substrates used for microplastics analysis and will focus on best practices for sample measurement and sotware functions in Clarity software for the analysis of microplastics.<blockquote>Presenter:&nbsp; Louis Tisinger, PhD (Application Engineer, Molecular Spectroscopy, Agilent Technologies, Inc.)Louis (Lou) Tisinger has a Ph.D. in Analytical Chemistry from Miami University in Oxford Ohio, where his graduate research involved the study of ATR imaging and microscope performance in vibrational spectroscopy. Most of his career has been related to pre- and post-sales support of FTIR spectrometers, microscopes, imaging systems, and thermal analytical instruments, focusing on analyzing customer samples, demonstrations, post-sales training, troubleshooting, and R&amp;D.</blockquote>

Agilent Technologies: Molecular spectroscopy webinars

A Workshop on Substrates and Software tools for Microplastics Analysis using the LDIR

This workshop will review the different substrates used for microplastics analysis and will focus on best practices for sample measurement and sotware functions

Software tools for Microplastics Analysis using LDIR

Direct Lithium Extraction (DLE) selectively recovers lithium from underground brines, producing high-purity lithium salts for batteries. Accurate analysis of major and trace elements is essential for quality control, but high dissolved solids and wide analyte ranges make lithium brines challenging to analyze. In this seminar, an Agilent 5900 ICP-OES with the Advanced Dilution System 2 (ADS 2) quantified key elements in different brine samples from DLE (raw, tail and lithium concentrate). The method demonstrated excellent matrix tolerance, long-term stability, and reliable elemental profiling, supporting robust quality control throughout the DLE workflow.<blockquote>Presenter: Ana García González (Atomic Spectroscopy Application Scientist, Agilent Technologies)Ana Garcia is the Atomic Spectroscopy Application Scientist at Agilent Technologies. Ana has a broad background in atomic spectroscopy technologies, including international experience developing and validating analytical spectroscopy methods for the geochemical industry. She has also published in the fields of molecular spectroscopy and chemometrics. Ana holds a MSc in plant Biotechnology at CINVESTAV, México, and a Bachelor of Science in Biotechnology Engineering.</blockquote>

Agilent Technologies: Atomic Spectroscopic webinars

High-Throughput ICP-OES Analysis of Elements in Brines from Direct Lithium Extraction

Learn how ICP-OES and advanced dilution improve elemental analysis of lithium brines in Direct Lithium Extraction for reliable quality control.

ICP-OES Analysis of Elements in Brines

Microplastics are increasingly detected across the environment and even within the human body, raising urgent questions about their sources, exposure pathways, and health implications.In this webinar, we will explore complementary analytical solutions for comprehensive microplastics characterization.Discover how FTIR and Raman spectroscopy enable reliable particle identification and imaging—covering sizes from millimeters down to a few microns—while high-resolution mass spectrometry techniques such as pyrolysis GC-HRMS and LC-based workflows provide sensitive detection and quantification of polymers and plastic-related chemicals in complex environmental and biological matrices.From particle-level identification to advanced chemical fingerprinting and exposure assessment, learn how Thermo Fisher Scientific technologies support micro- and nanoplastics analysis across research, environmental monitoring, and human biomonitoring applications.<blockquote>Speaker: Dr. Kuanliang Shao (Postdoctoral Fellow, Department of Environmental Health Comprehensive Laboratory for Untargeted Exposome Science | Emory University) will share how Py-GC-HRMS is enabling population-level biomonitoring of MNPs in human tissues and its integration into exposomics frameworks.Speaker:&nbsp;Dr. Wang Rui (Business Development Manager, Chemical Analysis | Thermo Fisher Scientific) will provide an overview of FTIR and Raman spectroscopy solutions for microplastics identification, highlighting how technologies ranging from point-and-shoot systems to advanced imaging platforms enable reliable analysis across diverse environmental samples and particle sizes, from millimeters down to a few microns.</blockquote>

Thermo Fisher Scientific: Uncovering Microplastics: Identification, Quantification, and Exposure Assessment

Uncovering Microplastics: Identification, Quantification, and Exposure Assessment

In this webinar, we will explore complementary analytical solutions for comprehensive microplastics characterization.

Microplastics Identification, Quantification

Organic contamination presents a persistent challenge across industries, particularly when particles are small, embedded, or difficult to isolate. This webinar introduces a combined focused ion beam–scanning electron microscopy (FIB-SEM) and FTIR microscopy workflow designed to support precise isolation and reliable identification of organic contaminants. By integrating targeted sample extraction with molecular analysis, this approach enables more complete characterization of foreign materials that may be missed using a single technique.Attendees will see how this workflow can support failure analysis and foreign material identification, with application examples relevant to pharmaceutical manufacturing where rapid, accurate identification is critical for product quality, safety, and regulatory compliance.<h4>In This Webinar, You Will Learn:&nbsp;</h4><ul><li>Fundamentals of FIB-SEM and FTIR microscopy and how they complement each other</li><li>A practical workflow for isolating and identifying organic microparticles</li><li>Techniques for FIB extraction, including milling and lift-out of targeted regions</li><li>Approaches to FTIR microscopy for analyzing small or embedded particles</li><li>Application insights for pharmaceutical contamination analysis and failure investigations&nbsp;</li></ul><h4>This Webinar is Ideal For:&nbsp;</h4><ul><li>Failure analysis scientists and engineers</li><li>QA/QC and quality assurance professionals</li><li>Pharmaceutical R&amp;D and manufacturing scientists</li><li>Analytical scientists working in materials characterization or contamination analysis</li><li>Academic and applied researchers (e.g., microplastics, materials science, life sciences)&nbsp;</li></ul><blockquote>Speaker: Matt Joens (Senior Sales Development Representative, Thermo Fisher Scientific)Matt Joens is an electron microscopist who has dedicated his career to the advancement of 3D and correlative imaging methodologies. He also has a passion for biological sample preparation, especially in the world of cryo preservation and the production of frozen lamella for high resolution TEM analysis. A chemist by training, Matt has worked at the Salk Institute, Washington University, Apple Inc, and TESCAN, spanning both life science and materials science disciplines. This duality has given him the unique perspective on what modern tools are capable of, and he now dedicates his time to help scientists find the right solutions for their research.Speaker: Jaspreet Singh, Phd (Senior Applications Scientist, Molecular Spectroscopy, Thermo Fisher Scientific)Jaspreet Singh earned his B.S. in Chemistry from the University of California, Merced in 2012 and his Ph.D. from the University of Oklahoma in 2021. Jaspreet’s graduate research work focused on variable temperature infrared spectroscopy studies of materials and development of FTIR sampling methods. Jaspreet is currently a Senior Application Scientist for the Nicolet FTIR spectroscopy product line at Thermo Fisher Scientific and operates an applications lab in San Jose, CA.</blockquote>

AZOM: Organic Contamination Analysis: A FIB-FTIR Workflow

Organic Contamination Analysis: A FIB-FTIR Workflow

Fundamentals of FIB-SEM and FTIR microscopy and how they complement each other

<h4>Achieving accurate results without calibration standards – A Thermo Fisher Scientific &amp; FLUXANA joint Webinar</h4>Accurate and flexible XRF quantification requires a solid theoretical foundation, robust instrumentation, and appropriate sample preparation. In this joint webinar hosted by FLUXANA® GmbH &amp; Co., Thermo Fisher Scientific introduces the principles behind UniQuant software’s standardless quantification and demonstrates how these are implemented on modern XRF instrumentation to deliver reliable results across a wide range of applications.Through practical application examples, the session highlights the accuracy and versatility of UniQuant software, while also addressing the critical influence of sample preparation on analytical performance. Drawing on FLUXANA’s expertise in sample preparation solutions, the webinar shows how optimized preparation methods complement UniQuant-based XRF workflows. Suitable for both beginners and experienced XRF users, this webinar provides practical guidance for building robust, high-quality XRF analyses.<blockquote>Speaker: Dr. Ling Schneider (Thermo Fisher Scientific™)Speaker: Dr. Rainer Schramm (FLUXANA® GmbH &amp; Co)Speaker: Lucie Longo (Thermo Fisher Scientific™)</blockquote>

Thermo Fisher Scientific: Unlocking standardless X-ray fluorescence analysis with Thermo Scientific™ UniQuant™ Software

Unlocking standardless X-ray fluorescence analysis with Thermo Scientific™ UniQuant™ Software

Discover standardless XRF quantification with UniQuant software, combining advanced instrumentation and sample prep for accurate, reliable results.

XRF analysis with Thermo Scientific UniQuant Software

Join our webinar to learn how Bruker AXS’s PHOTON IV X-ray detectors combine advanced active pixel sensor technology and innovative readout methods to deliver the precision needed for accurate diffraction data in modern crystallography research.Using real life examples, the webinar will introduce the technology behind the PHOTON IV X-ray detector and reveal the secrets enabling the PHOTON IV to measure highly accurate data from weakly diffracting samples including total scattering.<h4>Who should attend?</h4><ul><li>Crystallographers looking to implement the latest state-of -the-art technology into their X-ray facility</li><li>Anyone interested in the latest advances in X-ray detector technology</li></ul><h4>Which topics will be covered?</h4><ul><li>Trends in crystallography</li><li>Characteristics of an ideal SC-XRD X-ray detector</li><li>Photon counting detectors in SC-XRD past and future</li><li>The evolution of CMOS active pixel sensors&nbsp;</li><li>Photon counting in software and Interpixel Logic</li><li>The importance of quantum efficiency</li></ul><blockquote>Speaker:&nbsp;Dr. Vernon Smith (SC-XRD Business Development Manager, Bruker AXS)</blockquote>

Bruker: PHOTON IV: Learn How Unique Detector Technology is Driving Modern Crystallography

PHOTON IV: Learn How Unique Detector Technology is Driving Modern Crystallography

Join our webinar to learn how Bruker AXS’s PHOTON IV X-ray detectors combine advanced active pixel sensor technology and innovative readout methods.

PHOTON IV Unique Detector Technology

Raman spectroscopy is a powerful and increasingly accessible tool for analyzing the chemical and structural properties of materials across a wide range of industries. It enables fast, non-destructive analysis with minimal sample preparation - making it well suited for both research and quality-focused environments.In this webinar, we will introduce the fundamentals of Raman spectroscopy and explore how modern Raman systems deliver research-grade chemical insights through intuitive workflows and advanced imaging capabilities. Attendees will learn how Raman spectroscopy and microscopy can be used to identify unknown materials, visualize chemical distributions, and accelerate decision-making.We will also highlight key capabilities, such as confocal imaging, particle analysis, multilayer analysis and chemical mapping, that make the technique extremely valuable for product identification and testing across a wide range of applications. &nbsp;Join the free webinar with certification of attendance now. &nbsp;<h4>Join the Webinar to:</h4><ul><li>Understand the basic principles of Raman spectroscopy, including its use as a complementary technique to FTIR spectroscopy</li><li>Learn how Raman enables rapid, non-destructive chemical identification with minimal sample prep</li><li>Explore applications across a range of materials and industries</li><li>See how Raman imaging and microscopy reveal spatial chemical information</li><li>Identify how modern Raman systems improve usability, workflow efficiency, and data confidence</li></ul><h4>This Webinar is Ideal For:</h4><ul><li>Materials scientists and analytical chemists</li><li>R&amp;D and quality control professionals</li><li>Process and product development teams</li><li>Users evaluating Raman or complementary analytical techniques</li></ul><blockquote>Speaker: Sudhir Dahal, Ph.D. (Product Manager, Thermo Fisher Scientific)&nbsp;Sudhir Dahal is the Product Manager for Research Raman Products at Thermo Fisher Scientific, where he focuses on bringing advanced Raman spectroscopy solutions to market for demanding pharmaceutical and industrial applications. &nbsp;With over a decade of experience in analytical instrumentation, Sudhir works closely with customers, application teams and R&amp;D to translate real-world QC challenges – such as biopharma fill-finish testing, data robustness and scalability – into practical, automation-ready solutions. &nbsp;He holds a Ph.D. from the University of Maryland, Baltimore County, where he developed spectroscopy-based methods for biomedical analysis. Sudhir is passionate about connecting technology, workflow, and market needs to enable smarter, data-driven quality control.</blockquote>

Thermo Fisher Scientific: Unlocking Material Insights with Raman Spectroscopy: From Fundamentals to Real-World Applications

Unlocking Material Insights with Raman Spectroscopy: From Fundamentals to Real-World Applications

Learn Raman spectroscopy fundamentals, imaging, and applications for fast, non-destructive material analysis and improved laboratory workflows.

Material Insights with Raman Spectroscopy

Global supply chain disruptions are forcing industrial laboratories to qualify new material suppliers faster than ever before—often with limited insight into subtle but critical differences in material composition. Even when materials meet nominal specifications, variations in additives, processing, and structure can introduce significant risk to product performance, quality, and reliability.This webinar explores how FTIR spectroscopy can help laboratories detect variability, validate materials with confidence, and reduce risk in supplier qualification. Through real-world example, attendees will learn how improved characterization supports better decision-making, faster time-to-production, and more resilient manufacturing processes.<h4>Key Learning Objectives:</h4><ul><li>Understand the analytical risks introduced by supplier changes and complex material systems.</li><li>Identify practical characterization strategies that improve confidence in material qualification decisions.</li><li>Recognize how analytical workflows support cost control, quality assurance, and faster time-to-production.</li></ul><h4>Who Should Attend:</h4><ul><li>QA/QC Managers and Scientists&nbsp;</li><li>Analytical Laboratory Managers&nbsp;</li><li>Materials Scientists and Engineers&nbsp;</li><li>R&amp;D and Product Development Leaders&nbsp;</li><li>Manufacturing and Process Engineers</li></ul><blockquote>Speaker: Lena Woodis, PhD (Product Manager, Thermo Fisher Scientific)Speaker: Alexandra Taylor (Contributing Editor, C&amp;EN Media Group)</blockquote>

Thermo Fisher Scientific: Smarter Materials Qualification in a Changing Supply Chain

Smarter Materials Qualification in a Changing Supply Chain

Webinar explores how FTIR spectroscopy can help laboratories detect variability, validate materials with confidence, and reduce risk in supplier qualification.

The Indian pharmaceutical industry is entering a new phase of regulatory alignment as the Indian Pharmacopoeia Commission (IPC) moves toward implementing updated requirements for Elemental Impurities under IP Chapter 5.10, expected in July 2026. Aligned with the ICH Q3D guideline, the revised chapter introduces a comprehensive, risk-based framework to control elemental impurities arising from raw materials, catalysts, excipients, manufacturing processes, and container–closure systems. This transition reflects a broader global shift toward harmonized standards, including USP &lt;232&gt;/&lt;233&gt;, European Pharmacopoeia 5.20, and corresponding requirements across other major pharmacopeias. Together, these frameworks emphasize control based on permitted daily exposure (PDE) limits supported by scientifically sound risk assessments.As India aligns with these global expectations, pharmaceutical manufacturers must adopt robust analytical and risk management strategies to ensure compliance. This includes implementing sensitive, multi-element detection workflows, where ICP-MS has emerged as the industry benchmark. In this webinar, we will explore how laboratories can prepare for this transition by connecting regulatory expectations with practical analytical execution. The session will cover:<ul><li>Risk-based approaches for elemental impurity assessment aligned with ICH Q3D</li><li>Comparative perspectives across IP, USP, EP, and JP frameworks</li><li>Key considerations for analytical method development and multi-element screening</li><li>Practical ICP-MS workflows for reliable and compliant impurity monitoring</li></ul>Join us to learn how to design analytical strategies that ensure confident compliance with IP Chapter 5.10 while aligning with global standards - strengthening quality, regulatory readiness, and market competitiveness.<h4>Key Learning Outcomes</h4><ul><li>Understand upcoming IP 5.10 elemental impurity requirements and global alignment</li><li>Apply risk-based strategies for impurity identification and control</li><li>Select appropriate analytical approaches for multi-element detection</li><li>Implement ICP-MS workflows for reliable, compliant pharmaceutical testing</li></ul><blockquote>Presenter: Mr. Arvind Kumar Sharma (Scientific Assistant, Indian Pharmacopoeia Commission, Ministry of Health &amp; Family Welfare - Government of India)With six years of experience as a Scientific Assistant at Indian Pharmacopoeia Commission, he has played a key role in the current development of Indian Pharmacopoeia Reference Substances (IPRS) and Impurity Reference Substances. He has been engaged in the preparation and updating of draft monographs for publishing in Indian Pharmacopoeia (IP). Additionally, he has played a major role in the development of the latest edition of the National Formulary of India 2021 and has been involved in work related to the Pharmacovigilance Programme of India (PvPI). He holds a a M. Pharmacy in Pharmacology from Sinhgad Institute of Pharmaceutical Sciences, Pune and a B. Pharmacy from the College of Pharmacy, IPS Academy Indore. He has authored several articles published in international journals and organized and represented IPC at various national and international conferences and workshops. He has also participated in joint inspections for registration of manufacturing units and testing laboratories.Presenter: Dr. Vinay Jain (Application Engineer, Agilent Technologies, India)Dr. Vinay Jain is working as the CoE Manager and Country Food Workflow Commercialization Lead at Agilent Technologies International. He holds a Ph.D. in Analytical Chemistry and has more than 33 years of analytical and research experience in spectroscopic and mass spectrometry techniques.His specialization includes the development and validation of new analytical methods in accordance with regulatory guidelines. He has completed over 28 research projects with various national and international research and regulatory organizations. He holds two patents, has published 59 research papers, contributed two chapters to international handbooks, and authored 15 Agilent application notes. He received the Agilent TechInnovation Award in 2020 and 2022 for providing end-to-end workflow solutions. One of his innovations on LC-ICPMS was selected for the Winter Plasma Conference, and two were selected for the European Winter Plasma Conference for poster presentations.Presenter: Dr. Kuldeep Sharma (Business Development Manager - Pharma, Agilent Technologies)Dr. Kuldeep Sharma has over 23 years of experience in area of pharmaceuticals analytical R&amp;D, analytical method development and validation, clinical and preclinical studies, and regulatory compliance. His professional journey covers a true blend of technical and commercial industry insight, with a PhD in biotechnology, over 13 years as an analytical research scientist (with leading pharma companies like Zydus Cadila, Lambda, Teva, and Jubilant Biosys), and 10 years as techno-commercial expert leading analytical instruments sales strategies and marketing initiatives.During his industry experience, he has accomplished leading roles in domains covering analytical research, pharma quality compliance, and preclinical and analytical studies. With over 21 research articles published in international journals and 5 technical write-ups in leading magazines, he presents an attitude of continued learning, enabling him to acquire advance certifications of Lean Six Sigma-Black Belt and MBA (Operations Management) in addition to his professional journey.Presently, he works as a sales development manager for pharmaceutical markets at Agilent Technologies in India.</blockquote>

Agilent Technologies: Getting Elemental Impurity Testing Right: Preparing for upcoming regulatory changes with Advanced Analytical Workflows

Getting Elemental Impurity Testing Right: Preparing for upcoming regulatory changes with Advanced Analytical Workflows

Learn how to meet IP 5.10 elemental impurity requirements using ICP-MS, risk-based strategies, and global pharmacopeia alignment.

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