<h4><strong>The problem&nbsp;</strong></h4><p>We live in a “global village” but we are all different and we use many different languages to communicate.&nbsp;</p><p>Even when people speak the same language, the same words may be used with different meanings. See, for example, some different uses of the word “standard” in English – a normative document, a solution of known concentration or even a type of flag.&nbsp;</p><p>Even in the same area of activity misunderstandings do occur which may result in a waste of time and money, or even worse consequences.&nbsp;</p><p>When talking about laboratory tests, lack of a full understanding of key terms and inappropriate translations leaves room for different interpretations of stated requirements. For example, there have historically been a number of different but related uses of the term ‘<strong>detection limit’</strong>. This may lead to inadequate fulfilment of those requirements, thus becoming an obstacle to the production of analytical data that is fit for its intended use. A shared interpretation of concepts related to quality in measurement between laboratories and accreditation bodies is also crucial for a fair and harmonised approach to laboratory assessment across the world.&nbsp;</p><h4><strong>A common language&nbsp;</strong></h4><p>We need a <strong>common language</strong>; clear and unambiguous. We need a common vocabulary to provide consistent definitions of concepts with their associated terms. To this end, several organisations participate in a joint effort to develop and maintain an <strong>international vocabulary of metrology</strong> (VIM) [1], which aims to achieve a unique understanding of concepts related to measurements across all sectors. The VIM is a normative reference in the standards <strong>ISO/IEC 17025, ISO 15189 and ISO/IEC 17043</strong>, and is therefore a key document for all organisations seeking accreditation.&nbsp;</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Eurachem_You_talk_we_understand_The_way_out_of_the_tower_of_Babel_Standards_8d947dbd5f.jpg" alt="Eurachem: You talk, we understand – The way out of the tower of Babel_A common language" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Eurachem_You_talk_we_understand_The_way_out_of_the_tower_of_Babel_Standards_8d947dbd5f.jpg 245w," sizes="100vw" width="1126" height="499"></p><h4><strong>Is this enough?&nbsp;</strong></h4><p>For laboratory staff some problems still stand and need to be addressed:&nbsp;</p><ul><li>Many people are confused about both concepts and terms.&nbsp;</li><li>It may be difficult to understand the “formal” VIM definitions – they are short statements intended to apply to many different measurement sectors.</li><li>Translations into local languages may add to the confusion, e.g. if different terms are used in different sectors for the same VIM concept and the translator overlooks this issue.</li><li>Some substantial changes to terminology have been made in an attempt to accommodate chemical and biological measurements. Some “old” concepts still stand but have new names, e.g. “within laboratory reproducibility” vs. “intermediate precision”.&nbsp;</li></ul><p>To address these issues Eurachem has produced a guide [2] which provides an accessible reference containing simple and in context explanations of terms most relevant to analysts, with additional examples relating those concepts to chemical and biological measurements.&nbsp;</p><h4><strong>Do you understand the meaning of these terms?&nbsp;</strong></h4><p>Are you interested in a <strong>quantity</strong> or a quality? Depending on the answer, will you use a <strong>measurement</strong> <strong>procedure</strong> or an examination? Is method <strong>verification</strong> the same or less demanding than method <strong>validation</strong>? Do you need a <strong>calibration</strong> or just performance verification? Do you have a <strong>measurement standard</strong> in your laboratory? Is <strong>metrological traceability</strong> something you worry about? These are examples of the terms supporting the reliability of any measurement result that need to be clearly understood.&nbsp;</p><h5><strong>Example – Accuracy, trueness, precision: are they synonyms?&nbsp;</strong></h5><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Eurachem_You_talk_we_understand_The_way_out_of_the_tower_of_Babel_accuracy_231e1e005e.jpg" alt="Eurachem: You talk, we understand – The way out of the tower of Babel_Example – Accuracy, trueness, precision" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Eurachem_You_talk_we_understand_The_way_out_of_the_tower_of_Babel_accuracy_231e1e005e.jpg 146w," sizes="100vw" width="754" height="807"></p><ul><li>Closeness between measurement results (relating to the concept of precision)</li><li>Closeness of the average of the measurement results to a reference value (relating to the concept of trueness)&nbsp;</li><li>Closeness of an individual measurement result to the true value (relating to the concept of accuracy)&nbsp;</li></ul><p>The different situations in the figure show the effect of:&nbsp;</p><ol style="list-style-type:lower-latin;"><li>poor precision and trueness (imprecise and biased)&nbsp;</li><li>good precision, poor trueness (precise but biased)&nbsp;</li><li>poor precision, good trueness (imprecise but unbiased)&nbsp;</li><li>good precision and trueness (precise and unbiased)&nbsp;</li></ol><p>Improving both precision and trueness is expected to improve accuracy.&nbsp;</p><h4><strong>Is all this relevant to you?&nbsp;</strong></h4><p>Do you work in a laboratory, either as an analyst, quality manager or director? Are you involved in other activities related to analytical work, such as providing proficiency tests, producing reference materials or accrediting any such activity? Do you teach or study subjects related to measurements? Do you use measurement results or prescribe how to use them? <i><strong>If the answer is yes to any of these questions, the following reference documents are also for you</strong></i>.</p>

You talk, we understand – The way out of the tower of Babel

<p><strong>Visit the LabRulez booth at </strong><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/events/871"><strong>analytica 2026</strong></a><strong> in Munich, 24. - 27. March 2026! You can find us in Hall A1, Booth A1.506. At the booth, you will be able to explore live demonstrations of how the LabRulez portals work and see selected analytical instruments from our pre-owned marketplace section.</strong></p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Lab_Rulez_at_Analytica_2026_Floor_plan_55e1057e03.jpg" alt="LabRulez at Analytica 2026: Hall A1 Floor Plan and Booth Location" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Lab_Rulez_at_Analytica_2026_Floor_plan_55e1057e03.jpg 245w," sizes="100vw" width="1516" height="881"></p><h3><strong>Would you like to learn how the LabRulez portals work?</strong></h3><p>➡︎ <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/"><strong>LabRulezLCMS</strong></a><br>➡︎ <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/"><strong>LabRulezGCMS</strong></a><br>➡︎ <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/"><strong>LabRulezICPMS</strong></a></p><ul><li>A <strong>unique online solution</strong> for <strong>your marketing</strong></li><li>A <strong>targeted audience</strong> from the <strong>analytical chemistry community</strong></li><li><strong>Modern technologies</strong> and a unique concept</li><li><strong>Design optimized for most smart devices</strong> – PC, mobile, and tablet</li><li><strong>Advanced statistical tools</strong> fully available to users</li></ul><h3><strong>Services Offered</strong></h3><h4><strong>News + Company Updates</strong></h4><ul><li>Publish <strong>news related to your instrumentation, applications, services, events, job openings</strong>, and more</li><li><strong>News is shared</strong> both on our <strong>portals</strong> and across our <strong>social media channels</strong></li></ul><h4><strong>Library – All Documents in One Place</strong></h4><ul><li><strong>Applications, posters, presentations, technical articles, brochures, specifications</strong></li><li><strong>Fas</strong>t and <strong>advanced search</strong> capabilities</li><li>Over <strong>32,000 documents</strong> currently available in our database</li></ul><h4><strong>Webinars</strong></h4><ul><li><strong>Upcoming and on-demand webinars</strong> from the field of analytical chemistry</li><li>More than <strong>5,500 webinars</strong> covering chromatography, mass spectrometry, and spectroscopy</li></ul><h4><strong>Careers</strong></h4><ul><li><strong>Targeted job</strong> listings in <strong>analytical chemistry</strong></li><li>Clear filtering by specialization or location</li><li><strong>Increased visibility for job postings</strong></li></ul><h4><strong>Companies</strong></h4><ul><li><strong>Company profile</strong> with key information and contacts</li><li><strong>Integration of all your activities on our portal:</strong> News, Library documents, Webinars, Upcoming Events, Careers, and mentions by partners or customers</li><li><strong>Connection to your Products </strong>listed on LabRulez portals</li></ul><h4><strong>Products and Services</strong></h4><ul><li>Comprehensive <strong>overview of instrumental techniques and services</strong></li><li>Targeting the analytical chemistry community and customers in the growing online environment</li></ul><h4><strong>Marketplace</strong></h4><ul><li><strong>Buying and selling pre-owned analytical equipment</strong></li><li>We purchase analytical instrumentation of all brands and ages</li><li><strong>Sell your equipment through LabRulez</strong></li><li>Request and purchase <strong>complete systems, modules</strong>, or <strong>spare parts</strong> with warranty and service</li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Lab_Rulez_at_analytica_2026_bazar_7edf4a0872.jpg" alt="LabRulez at analytica 2026" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Lab_Rulez_at_analytica_2026_bazar_7edf4a0872.jpg 88w," sizes="100vw" width="1600" height="2844"></p><h3><strong>What Will Be on Display at Our Booth?</strong></h3><p>Come and explore selected spare parts and modules from our marketplace section. These include both new, tested, and pre-owned items.</p><h4><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/bazaar"><strong>LabRulezLCMS Marketplace</strong></a></h4><p><strong>Spare parts for LC/MS:</strong></p><ul><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/bazaar?category=378"><strong>Vacuum turbo pumps for LC/MS</strong></a></li></ul><p><strong>Spare parts for HPLC:</strong></p><ul><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/bazaar?category=397"><strong>Degassers for HPLC/UHPLC</strong></a></li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/bazaar?category=368&amp;search=valve"><strong>Automatic valves for HPLC</strong></a></li><li>HPLC components for Agilent 1100, 1200, and 1260 Infinity II series</li></ul><p><strong>Consumables:</strong></p><ul><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/bazaar?category=377"><strong>HPLC lamps</strong></a></li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/bazaar?category=48"><strong>HPLC columns</strong></a></li></ul><h4><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/bazaar"><strong>LabRulezGCMS Marketplace</strong></a></h4><p><strong>Spare parts for GC/MS:</strong></p><ul><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/bazaar?category=367&amp;search=turbo"><strong>Turbo pumps for GC/MS</strong></a></li></ul><p><strong>Spare parts for GC:</strong></p><ul><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/bazaar?category=366&amp;search=EPC"><strong>EPC modules</strong></a></li></ul><p><strong>Sample injection</strong></p><ul><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/bazaar/432"><strong>Autosampler 7693A for GC</strong></a></li></ul><p><strong>Consumables:</strong></p><ul><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/bazaar?category=7"><strong>GC columns </strong></a>and selected accessories</li></ul>

LabRulez at analytica 2026

<p><strong>Our Library never stops expanding. What are the most recent contributions to LabRulezICPMS Library in the week of 23rd March 2026? Check out new documents from the field of spectroscopy/spectrometry and related techniques!</strong></p><blockquote><p><span style="font-size:20px;">👉 </span><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/library"><span style="font-size:20px;"><strong>SEARCH THE LARGEST REPOSITORY OF DOCUMENTS ABOUT SPECTROSCOPY/SPECTROMETRY RELATED TECHNIQUES</strong></span></a></p></blockquote><blockquote><p><strong>👉 Need info about different analytical techniques?</strong> Peek into <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/library"><strong>LabRulezLCMS</strong></a> or <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library"><strong>LabRulezGCMS</strong></a> libraries.</p></blockquote><p>This week we bring you application notes by <strong>LECO,</strong> <strong>Shimadzu </strong>and <strong>Waters Corporation</strong> and brochure by<strong> Thermo Fisher Scientific!</strong></p><h3><strong>1. LECO: Determination of Nitrogen in Fertilizer</strong></h3><ul><li>Application note</li><li><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/labrulez-bucket-strapi-h3hsga3/CN_FP_928_NITROGEN_FERTILIZERS_203_821_615_4d4b013a08.pdf"><strong>Full PDF for download</strong></a></li></ul><p>Nitrogen is one of the most important elements for plant development and is the macronutrient that is most often found to be deficient in arable soils used for crop production. Nitrogen plays a key role in the formation of enzymes and proteins, which promotes lush, vigorous growth and development in plants that often leads to an increase in the yield from the plant. Fertilizers are utilized to re-introduce nitrogen back into arable soils. Fertilizers can be grouped by their makeup and/or origins into categories including inorganic and/or synthetic (including nitrates, ammonium, and urea) and organic (including compost materials and manures). The accurate and precise determination of nitrogen in all fertilizer types is not only important in the process of blending and preparing the fertilizer material for use, but also will have significant impact on the commercial value and guarantee of the fertilizer.&nbsp;</p><p>The CN928/FP928 is a macro combustion carbon and nitrogen/protein determinator that utilizes a pure oxygen environment in a high-temperature horizontal ceramic combustion furnace designed to handle macro sample mass. A thermoelectric cooler removes moisture from the combustion gases before they are collected in a ballast. The gases equilibrate and mix in the ballast before a representative aliquot (3 cm<sup>3</sup> or 10 cm<sup>3</sup> volume) of the gas is extracted and introduced into a flowing stream of inert gas (helium or argon) for analysis. The aliquot gas is carried to a thermal conductivity cell (TC) for the detection of nitrogen (N<sub>2</sub>).</p><h4><strong>Instrument Model and Configuration&nbsp;</strong></h4><p>Thermal conductivity detectors work by detecting changes in the thermal conductivity of the analyte gas compared to the constant thermal conductivity of the reference/carrier gas. The greater the difference between the thermal conductivity of the carrier gas and the analyte gas, the greater the sensitivity of the detector. The <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/library?mainauthorItems=24&amp;search=CN928"><strong>CN928</strong></a>/<a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/library?mainauthorItems=24&amp;search=FP928"><strong>FP928</strong></a> supports either the use of helium or argon as the instrument's carrier gas. When used as a carrier gas, helium provides the highest sensitivity, and the best performance at the lower limit of the nitrogen range. The thermal conductivity difference between argon and nitrogen is not as great as the thermal conductivity difference between helium and nitrogen, therefore the detector is inherently less sensitive when using argon as a carrier gas.</p><h4><strong>TYPICAL RESULTS&nbsp;</strong></h4><p>Data was generated utilizing a single standard, forced through origin calibration using ~ 0.1 g of NIST 913b Uric Acid (33.23% N). Alternatively, LECO 503-530 LCRM Urea may be used for calibration.</p><h3><strong>2. Shimadzu: Evaluation of Microscopic Foreign Matter in Recycled Plastics Using Dynamic Image Analysis, Infrared Microscopy, and SEM-EDS</strong></h3><ul><li>Application note</li><li><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/labrulez-bucket-strapi-h3hsga3/an_01_00861_en_7485baba21.pdf"><strong>Full PDF for download</strong></a></li></ul><h4><strong>User Benefits</strong></h4><ul><li>&nbsp;It is easy to evaluate the size and quantity of microscopic foreign particles, which are key quality criteria of recycled plastics.</li><li>With the microcell method of DIA, microscopic foreign matter can be detected and counted quickly using a small sample quantity.</li><li>Infrared microscope and SEM-EDS systems provide information about the morphology and composition of microscopic foreign matter that is useful for improving recycling processes.</li></ul><p>One of the quality criteria for recycled plastic flakes and pellets is the content of foreign matter. Quantitatively evaluating the size and quantity of foreign particles contained in flakes and pellets is important for examining foreign matter removal processes intended to improve pellet quality and optimize manufacturing processesfor products made with recycled materials.&nbsp;</p><p>In this article, pellets of virgin and recycled polyethylene terephthalate (hereafter PET) were dissolved in hexafluoro-2-propanol (hereafter HFIP), a solvent for dissolving PET, to prepare suspensions of insoluble microscopic foreign particles. These suspensions were measured with a dynamic particle image analysis (DIA) system (<a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/library?mainauthorItems=1&amp;search=iSpect+DIA-10"><strong>iSpect DIA-10</strong></a>) to evaluate the size and number of insoluble microscopic foreign particles (patent pending). In addition, part of the suspensions were diluted tenfold and filtered through a membrane filter to collect the insoluble microscopic foreign particles on the filter. The morphology and composition of the collected microscopic foreign particles were evaluated using a digital microscope, an infrared microscope system (<a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/library?mainauthorItems=1&amp;search=IRTracer-100"><strong>IRTracer-100</strong></a> and <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/library?mainauthorItems=1&amp;search=AIM-9000"><strong>AIM-9000</strong></a>), and an SEM-EDS system. These evaluations enabled comparison of the sizes, quantities, and types of foreign particles contained in virgin and recycled materials.</p><h4><strong>Conclusion&nbsp;</strong></h4><p>By using an iSpect DIA-10 system to measure suspensions prepared by dissolving two types of PET pellets (virgin and recycled) in HFIP, we obtained particle images of insoluble foreign matter and evaluated size and concentration of particles. That enabled quantitative comparison of particle size and count in microscopic foreign matter contained in virgin and recycled materials.&nbsp;</p><p>In addition, after diluting the pellet suspensions, the insoluble microscopic foreign matter in the diluted suspensions was collected on filters. The morphology and composition of the microscopic foreign matter were evaluated using an infrared microscope and SEM-EDS system. The results indicated that the suspensions contained organic substances, such as cellulose and amide-based compounds, and inorganic substances and metals that contain elements such as C, O, Ca, and Al (suggestive of carbonates and metallic aluminum).&nbsp;</p><p>Thus, the iSpect DIA-10 enables simple quantitative evaluation of the size and number of microscopic foreign particles in PET pellets using only small sample quantities. Furthermore, composition evaluation by infrared microscope and SEM-EDS systems provides useful information for investigating the origin of foreign matter, examining measures to reduce foreign matter, and evaluating impacts on final products. If similarities in size and shape are observed, particle images obtained with iSpect DIA-10 can also potentially be used to estimate particle composition.</p><h3><strong>3. Thermo Fisher Scientific: Ensuring safer and effective pharmaceutical formulations by X-ray diffraction</strong></h3><ul><li>Brochures and specifications</li><li><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/labrulez-bucket-strapi-h3hsga3/PF_41381_xrd_solutions_pharma_9b89684165.pdf"><strong>Full PDF for download</strong></a></li></ul><p>From drug discovery and preformulation studies to the efficient scaling up in the manufacturing process in the plant and finally through QA/QC validation, X-ray diffraction (XRD) is a vital analysis method in the characterization of different physico-chemical properties of the active pharmaceutical ingredient (API). XRD is a gold standard method and required technique in the determination of polymorphic and salt screening, % of crystallinity and stability/reactivity studies of the final API.&nbsp;</p><h5><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/products/2297"><strong>Thermo Scientific™ SolstiX™ XRD Software</strong></a><strong> with Security Suite extends ARL EQUINOX 100 X-ray Diffractometers to 21 CFR Part 11 regulated labs&nbsp;</strong></h5><ul><li>Protect stored electronic data related to quality assurance within manufacturer’s computer systems&nbsp;</li><li>Put controls in place to keep records authentic, incorruptible, and confidential&nbsp;</li><li>Electronic signatures for the user to take responsibility for the electronic data in the system&nbsp;</li><li>Requirements in the data record: date and time of scan, name of the unique signer, and technological controls to ensure security (e.g. passwords)&nbsp;</li></ul><h5><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/products/2143"><strong>Thermo Scientific™ ARL™ EQUINOX 100 X-ray benchtop diffractometer</strong></a><strong> is designed to exceed your analytical needs&nbsp;</strong></h5><ul><li>Ideally suited for rapid screening of various formulations, finger printing or detection of counterfeit products&nbsp;</li><li>Polymorphism and crystallinity determination, crystallite size calculation, quantitative phase analysis, reactivity and stability of materials, etc.&nbsp;</li><li>XRD experiments on standard powders, bulks, tablets, small quantities, etc.&nbsp;</li><li>Real-time full pattern XRD based on our unique PSD detector technology&nbsp;</li><li>X-ray source based on micro-source technology with no external water cooling</li><li>Unique dual-mode capability: reflection and/or transmission&nbsp;</li></ul><h5><strong>Thermo Scientific™ ARL™ EQUINOX 100 XRD for structural analysis&nbsp;</strong></h5><ul><li>Easy-to-use simultaneous full pattern XRD based on unique real time PSD detector technology&nbsp;</li><li>Unique dual-mode capability on a benchtop XRD instrument: reflection and/or transmission mode&nbsp;</li><li>XRD experiments on various samples with sample spinner, capillary stage, sample changer or in controlled environment</li></ul><h5><strong>Top XRD benefits for pharma&nbsp;</strong></h5><ul><li>Structural characterization technique&nbsp;</li><li>Nondestructive technique&nbsp;</li><li>Small amount of sample needed for analysis&nbsp;</li><li>Unique diffraction patterns and quick response&nbsp;</li><li>Analysis on mixtures as well as amorphous content&nbsp;</li><li>Easy determination of induced structural changes</li></ul><h3><strong>4. Waters Corporation: SIMI: A Different Approach to Revealing Dangerous Subvisible Impurities</strong></h3><ul><li>Application note</li><li><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/labrulez-bucket-strapi-h3hsga3/720009094_en_fb955e89ec.pdf"><strong>Full PDF for download</strong></a></li></ul><p>Foreign particulate matter, also known as extrinsic particles, has become a serious threat to patient safety in recent years, with cases linked to severe immunogenic reactions, deaths, and costly recalls.<sup>1</sup> In 2021 alone, Takeda recalled 1.6 million doses of the Moderna COVID-19 mRNA vaccine in Japan after several patient deaths were linked to steel particulates shed from a malfunctioning pump.<sup>2</sup> Over the span of seven years, from 2014–2017, there were more than 110 drug recalls as a result of glass delamination,<sup>3–4</sup> and several more due to remnant crystals,<sup>5</sup> owing to the difficulty of identifying the presence and source of foreign particulate matter. To prevent against such threats, manufacturers require high throughput technologies to better identify foreign particulate matter in real time.</p><h4><strong>Results and Discussion</strong></h4><h5><strong>Shining a Light on Extrinsic Particles with SIMI</strong></h5><p>Side illumination membrane imaging (SIMI) is a proprietary illumination, imaging, and analysis technique exclusively available to <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/products/2190"><strong>Aura instruments</strong></a>. Utilizing the principles of darkfield microscopy,<sup>6</sup> SIMI is conducted on an Aura membrane plate using an oblique illumination source which emits light at an angle parallel to the surface of the plate.&nbsp;</p><p>Compared to backgrounded membrane imaging (BMI), which utilizes brightfield microscopy (epi-illumination) where particles scatter the incident light isotropically (i.e., at all angles), side illumination membrane maging (SIMI) is a technique that is specifically designed to detect light scattering from high refractive index particles, as well as those that protrude out of the plane from the membrane surface. A particle’s average SIMI intensity is measured in a relative scale where the inherent SIMI scattering of the membrane is defined as SIMI = 0. Positive SIMI values indicate particles protruding out of the membrane, as is the case with microplastics, fibers, and other common extrinsic particles, whose average SIMI intensities vary from 0–255. On some occasions, like with metallic particles and absorbing oils, particles will have reduced light refraction relative to the membrane and thus display negative SIMI values, varying from 0 to -122.&nbsp;</p><p>The majority of foreign, extrinsic particles exhibit a high refractive index and are mechanically rigid in structure, causing them to protrude from the membrane surface and scatter side illumination to a high degree, ideal for SIMI analysis. In contrast, biologic particles exhibit the opposite properties—low refractive index and malleable structures, causing them to lie flat with minimal side scatter profiles, which is best analyzed with BMI or fluorescence membrane microscopy (FMM). Utilizing all three microscopy approaches is most ideal to facilitate the determination of all extrinsic (non-biologic) and inherent (biologic) particles in biologic formulations.</p><h4><strong>Conclusion&nbsp;</strong></h4><p>SIMI is a unique approach to providing additional characterization of subvisible particles and is available in all Aura models to help rapidly identify foreign material in biological samples with a high degree of specificity. A key tertiary imaging mode in addition to BMI and FMM, SIMI provides selective, orthogonal morphological information to identify tall and rigid materials, a defining feature of most extrinsic particles (Figure 11). While particle sizing and counting is done via BMI, SIMI provides illumination, imaging, and analysis that can be useful across a variety of biological products to reveal foreign subvisible particles from the earliest to the latest of stages in the bioprocess.</p>

News from LabRulezICPMS Library - Week 13, 2026

Article

Events

Application

Science and research

Eurachem is a European network promoting international traceability of chemical measurements and good analytical practice. It provides expert guidance, supports method validation, uncertainty evaluation, proficiency testing, and facilitates discussion on technical and policy issues in analytical quality.

Eurachem

Everything from the world of analytical chemistry in one place. We connect people in solving their problems. At Labrulez you will find all the necessary information easily, quickly and clearly. Stop searching and start finding.

LabRulez

Metrohm

Agilent Technologies

Technology Networks

Thermo Fisher Scientific

<p><strong>This discussion will go in depth into how the fully integrated Auto Dilution System (ADS 2) can streamline your ICP-MS workflow.  Eliminate bottles and bottle necks by automating the creation of Calibration and QC standards as well as intelligent handling of unknown samples.</strong></p>
<p>Join us to learn how the ADS 2 can streamline your day-to-day ICP-MS workflow and improve your lab efficiency.</p>
<blockquote>
<p><strong>Presenter:</strong> Bert Woods (Application Scientist, Agilent Technologies, Inc.)</p>
</blockquote>
<blockquote>
<p>Joined the Agilent ICP-MS team in 2004, with previous employment in the semiconductor industry with Dominion Semiconductor (IBM/Toshiba) and Micron. Bert is a 1997 Chemistry graduate of Radford University in Virginia and an avid Washington DC Sports fan.</p>
</blockquote>


Agilent Technologies: Productive Analysis of High Matrix Samples using ICP-MS with the Integrated Advanced Dilution System

Productive Analysis of High Matrix Samples using ICP-MS with the Integrated Advanced Dilution System

This discussion will go in depth into how the fully integrated Auto Dilution System (ADS 2) can streamline your ICP-MS workflow. 

ICP-MS with the Integrated Advanced Dilution System

<p><strong>TBS... Trace level Analysis of NonTraditional elements and MultiElement Nanoparticles in Solvents by ICP-QQQ: A Semiconductor Workshop</strong></p>
<blockquote>
<p><strong>Presenter:</strong> Bert Woods (Application Scientist, Agilent Technologies, Inc.)</p>
</blockquote>
<blockquote>
<p>Joined the Agilent ICP-MS team in 2004, with previous employment in the semiconductor industry with Dominion Semiconductor (IBM/Toshiba) and Micron. Bert is a 1997 Chemistry graduate of Radford University in Virginia and an avid Washington DC Sports fan.</p>
</blockquote>


Agilent Technologies: Trace level Analysis of NonTraditional elements and MultiElement Nanoparticles in Solvents by ICP-QQQ: A Semiconductor Workshop

Trace level Analysis of NonTraditional elements and MultiElement Nanoparticles in Solvents by ICP-QQQ: A Semiconductor Workshop

Nanoparticles in Solvents by ICP-QQQ: A Semiconductors

<p><strong>TBS... Elemental Analysis of Lithium-ion Battery Samples using ICP-OES and ICP-MS</strong></p>
<blockquote>
<p><strong>Presenter:</strong> L. Craig Jones (ICP-MS Application Scientist, Agilent Technologies, Inc.)</p>
</blockquote>
<blockquote>
<p>Craig has been with Agilent for over 15 years as an ICP-MS applications scientist. He has been involved with multiple type of applications for ICP-MS, including environmental, pharmaceutical, semiconductor, geologic, and clinical analyses, to name a few. Previous to Agilent he worked in an environmental lab performing analysis and supervising both the inorganic and organic sections of the laboratory. In his spare time, Craig enjoys volunteering at the local marine science center, mountain biking, hiking, and relaxing at the beach. Craig obtained a Bachelor of Science degree in chemistry from Fort Lewis College in Durango, CO.</p>
</blockquote>
<blockquote>
<p><strong>Presenter:</strong> Sima Singha, PhD (ICP-OES Application Scientist, Atomic Spectroscopy, Agilent Technologies, Inc.)</p>
</blockquote>
<blockquote>
<p>Sima has over fifteen years of hands on experience as an applications scientist in the field of atomic spectroscopy. Before joining Agilent in 2017, managed an agricultural chemistry laboratory for the analysis of water, soil, and plant tissue digests using ICP-OES for various EPA methods. She received a Ph.D. degree in Chemistry from the University of Illinois at Chicago with numerous peer-reviewed publications.</p>
</blockquote>


Agilent Technologies: Elemental Analysis of Lithium-ion Battery Samples using ICP-OES and ICP-MS

Elemental Analysis of Lithium-ion Battery Samples using ICP-OES and ICP-MS

Lithium-ion Batteries Analysis using ICP-OES and ICP-MS

<p><strong>TBS... Agilent M Lens for ICP-MS and the Semiconductor Industry</strong></p>
<blockquote>
<p><strong>Presenter:</strong> Bert Woods (Application Scientist, Agilent Technologies, Inc.)</p>
</blockquote>
<blockquote>
<p>Joined the Agilent ICP-MS team in 2004, with previous employment in the semiconductor industry with Dominion Semiconductor (IBM/Toshiba) and Micron. Bert is a 1997 Chemistry graduate of Radford University in Virginia and an avid Washington DC Sports fan.</p>
</blockquote>


Agilent technologies: Agilent M Lens for ICP-MS and the Semiconductor Industry

Agilent M Lens for ICP-MS and the Semiconductor Industry

<p><strong>Explore the latest knowledge on the safety, authenticity and quality of food and beverages, as well as the technology that supports the critical work done to ensure the integrity of the food supply chain.</strong></p>
<h5>This online symposium will explore:</h5>
<ul>
<li><strong>Untargeted analysis techniques used to ensure food authenticity</strong></li>
<li><strong>Sample preparation techniques for food applications</strong></li>
<li><strong>Use of thermal infrared imaging for salmonella detection</strong></li>
<li><strong>Elemental analysis for food and beverage testing</strong></li>
<li><strong>Miniaturized food analysis devices</strong></li>
<li><strong>Sustainable lab consumables for food analysis</strong></li>
<li><strong>Heavy metals in processed baby food</strong></li>
<li><strong>Residual analysis using GC/MS</strong></li>
</ul>
<h3><strong>Day 1 – July 24</strong></h3>
<h5><strong>16:00 – 17:00 BST How to Use and Interpret Untargeted Testing for Food Authenticity</strong></h5>
<ul>
<li>John Points, Kate Kemsley, PhD and Catherine Frankis, PhD (Food Authenticity Network)</li>
</ul>
<h5><strong>17:00 – 17:10 BST</strong> Networking Break</h5>
<h5><strong>17:10 – 17:55 BST Beyond All Limits: Elevating the Standards of Residual Analysis with Triple Quadrupole GC/MS</strong></h5>
<ul>
<li>Joel Ferrer and Anastasia Andrianova, PhD (Agilent)</li>
</ul>
<h5><strong>17:55 – 18:00 BST</strong> Networking Break</h5>
<h5><strong>18:00 – 18:20 BST Elemental Analysis Trends and Advances in Food and Beverage Testing</strong></h5>
<ul>
<li>Nikolay Kovachev, PhD (Agilent)</li>
</ul>
<h5><strong>18:20 – 18:30 BST</strong> Networking Break</h5>
<h5><strong>18:30 – 19:10 BST The Use of Thermal Infrared Cameras for Pathogen Detection (Salmonella) on Tomato Surfaces</strong></h5>
<ul>
<li>Andy Moreno, PhD (AME Certified PCR AI Laboratories)</li>
</ul>
<h5><strong>19:10 – 19:20 BST</strong> Networking Break</h5>
<h5><strong>19:20 – 19:40 BST About the Use of Micro-SPE for an Automated and Green Sample Preparation</strong></h5>
<ul>
<li>Hans-Joachim Hübschmann, PhD (PAL System)</li>
</ul>
<h5><strong>19:40 – 19:50 BST</strong> Networking Break</h5>
<h5><strong>19:50 – 20:30 BST Driving Behaviors for Food and Beverage Breakthroughs</strong></h5>
<ul>
<li>Trevor Morones, PhD (Control Point)</li>
</ul>
<h5><strong>20:30 BST</strong> End of Day 1</h5>


Technology Networks: Advances in Food and Beverage Testing 2024

Advances in Food and Beverage Testing 2024 (Day 1)

Explore the latest knowledge on the safety, authenticity and quality of food and beverages.

<p><strong>Explore the latest knowledge on the safety, authenticity and quality of food and beverages, as well as the technology that supports the critical work done to ensure the integrity of the food supply chain.</strong></p>
<h5>This online symposium will explore:</h5>
<ul>
<li><strong>Untargeted analysis techniques used to ensure food authenticity</strong></li>
<li><strong>Sample preparation techniques for food applications</strong></li>
<li><strong>Use of thermal infrared imaging for salmonella detection</strong></li>
<li><strong>Elemental analysis for food and beverage testing</strong></li>
<li><strong>Miniaturized food analysis devices</strong></li>
<li><strong>Sustainable lab consumables for food analysis</strong></li>
<li><strong>Heavy metals in processed baby food</strong></li>
<li><strong>Residual analysis using GC/MS</strong></li>
</ul>
<h3><strong>Day 2 – July 25</strong></h3>
<h5><strong>16:00 – 16:40 BST Miniaturization of Analytics: A Better Control from Farm to Fork</strong></h5>
<ul>
<li>Marta Prado, PhD (University of Santiago de Compostela)</li>
</ul>
<h5><strong>16:40 – 16:50 BST</strong> Networking Break</h5>
<h5><strong>16:50 – 17:10 BST Unleashing the Power of AI powered LIMS in Food and Beverage Testing</strong></h5>
<ul>
<li>Daniel Call (LabVantage)</li>
</ul>
<h5><strong>17:10 – 17:20 BST</strong> Networking Break</h5>
<h5><strong>17:20 – 18:00 BST Heavy Metals in Processed Baby Food: Could Regulators be Doing More to Ensure Consumer Safety?</strong></h5>
<ul>
<li>Robert Thomas (Scientific Solutions)</li>
</ul>
<h5><strong>18:00 – 18:10 BST</strong> Networking Break</h5>
<h5><strong>18:10 – 18:30 BST Sustainable Lab Consumables without Compromising Performance</strong></h5>
<ul>
<li>Jack Gikonyo (Eppendorf Americas)</li>
</ul>
<h5><strong>18:30 – 18:40 BST</strong> Networking Break</h5>
<h5><strong>18:40 – 19:20 BST Applications of NIRS and NIR Imaging in Food</strong></h5>
<ul>
<li>Vincent Baeten, PhD (Walloon Agricultural Research Centre)</li>
</ul>
<h5><strong>19:20 BST</strong> Event Close</h5>


Advances in Food and Beverage Testing 2024 (Day 2)

<p><strong>High matrix samples, such as those containing high dissolved solids, can often be challenging potentially resulting in poor data quality and instrument performance, leading to excess maintenance.</strong></p>
<p>In this webinar we will discuss the techniques available to deal with these samples.</p>
<blockquote>
<p><strong>Presenter:</strong> David Fishwick (Applications Specialist, TEA, Thermo Fisher Scientific)</p>
</blockquote>
<blockquote>
<p>David joined Thermo in 2022 as an Applications Specialist for the Trace Elemental Analysis product range in the UK and Ireland. Prior to joining Thermo, David has gained experience of trace elemental analysis and chromatography in industry, working in GMP, GLP and UKAS accrediated R&amp;D and pharmaceutical laboratories. David holds a BSc in Chemistry from Bangor University.</p>
</blockquote>
<blockquote>
<p><strong>Presenter:</strong> Matthew Gregory (Applications Specialist, TEA, Thermo Fisher Scientific)</p>
</blockquote>
<blockquote>
<p>After graduating from the University of Surrey with an MChem in Chemistry, Matthew has gained 20 years’ experience of trace elemental analysis in industry, working in environmental and precious metal research laboratories. In 2018, Matthew joined Thermo Fisher Scientific as an Applications Specialist for the Trace Elemental Analysis product range in the UK and Ireland.</p>
</blockquote>


Thermo Scientific: Dealing with the Complexity of High Matrix Samples on ICP-OES and ICP-MS

Dealing with the Complexity of High Matrix Samples on ICP-OES and ICP-MS

Techniques available to deal with these samples.

Complexity of High Matrix Samples ICP-OES amd ICP-MS

<p><strong>Elemental impurities are trace metals or elements that can be present in pharmaceuticals, impacting product safety and efficacy.</strong></p>
<p>USP General Chapter &lt;232&gt; provides guidelines for controlling elemental impurities in pharmaceuticals, ensuring they meet acceptable levels for human consumption. Compliance with USP &lt;232&gt; is crucial for regulatory approval and maintaining product quality and safety.</p>
<p>Register to attend this Webinar and learn:</p>
<ul>
<li><p><strong>Elemental impurities as per USP 232/USP 233 and ICHQ3D</strong></p>
</li>
<li><p><strong>Dive into the innovation that powers USP-232 guidelines</strong></p>
</li>
<li><p><strong>Agilent&#39;s MH software with Agilent&#39;s complete workflow solutions</strong></p>
</li>
<li><p><strong>Basic maintenance and early maintenance feedback of ICP-MS</strong></p>
</li>
</ul>
<blockquote>
<p><strong>Presenter:</strong> Dr. Kuldeep Sharma (Sales Development Manager - Pharma, Agilent Technologies)</p>
</blockquote>
<blockquote>
<p>Kuldeep Sharma has over 19 years of experience in area/s of Bioanalytical research, Drug metabolism &amp; pharmacokinetics and Pharma regulatory compliance. He has accomplished PhD in Biotechnology. His professional journey covers over 12 years in Analytical research (associated with R&amp;D’s of Zydus Cadila, Lambda, Pliva and Jubilant Biosys) and last 7 years in analytical instruments sales, marketing &amp; business development. With over 21 research articles published in international Journals, He presents convention of continues learning.</p>
</blockquote>
<blockquote>
<p><strong>Presenter:</strong> Mr. Radhey Shyam (Application Specialist - Spectroscopy, Agilent Technologies)</p>
</blockquote>
<blockquote>
<p>Radhey Shyam is an Application Scientist responsible for Elemental Spectroscopy Solutions at Agilent Technologies at Centre of Excellence (COE) Lab, Manesar. He has been assisting in the development of new methods and applications, as well as providing training and educational activities for customers across various sectors on spectroscopy solutions and technologies for the past 10+ years. He has authored several publications in international journals. In addition, he has also contributed to global application and solution notes from Agilent, with a focus on spectroscopy Market.&quot;</p>
</blockquote>
<blockquote>
<p><strong>Presenter:</strong> Mr. Ankush Sharma (Regional Marketing Program Manager- APAC (Pharma &amp; Biopharma), Agilent Technologies)</p>
</blockquote>
<blockquote>
<p>Ankush Sharma is a seasoned professional with over 12 years of extensive experience in sales and marketing across the pharmaceutical and biopharmaceutical sectors. His professional journey commenced with a strong educational foundation, earning a Master&#39;s degree in Biotechnology. Building upon this knowledge, he furthered his academic pursuits by obtaining a Master&#39;s in Business Administration with a specialization in Sales and Marketing, demonstrating his commitment to blending scientific understanding with strategic business acumen. For the past five years, he has been an integral part of Agilent, serving as the Regional Marketing Program Manager for the India and now Asia-Pacific (APAC) region for Pharma and Biopharma Markets.</p>
</blockquote>


Agilent Technologies: Demystifying USP & ICHQ3D Guidelines for Elemental Impurities

Demystifying USP & ICHQ3D Guidelines for Elemental Impurities

Elemental impurities as per USP 232/USP 233 and ICHQ3D.

Demystifying USP & ICHQ3D Guidelines for Elemental Impuritie

<p><strong>As part of the global effort to reduce CO₂ emissions, biofuels are becoming an increasingly important source of green energy.</strong></p>
<p>Quality control testing of biofuels is therefore crucial to ensure the efficiency and reliability of biogas, biodiesel, and fuel ethanol.  </p>
<p>In this webinar you will learn about the latest laboratory testing techniques that are used to ensure the quality, efficiency, and sustainability of modern biofuels to enable producers to confidently meet international regulatory requirements and to promote their widespread adoption in both industry and the wider society at large. </p>
<p>Experts from Agilent Technologies will introduce a wide range of analytical testing solutions covering multiple technologies that are routinely used to detect organic and inorganic impurities in biodiesel and enable the stringent quality control of fuel ethanol, biogas and biogas blends to be achieved. The expert panel will be available to answer questions from the audience at the end of the presentation. </p>
<blockquote>
<p><strong>Presenter:</strong> Danny van Oevelen (LC Product Specialist, Agilent Technologies)</p>
</blockquote>
<blockquote>
<p><strong>Presenter:</strong> Luca Godina (GC &amp; GC/MS Application Specialist, Agilent Technologies)</p>
</blockquote>
<blockquote>
<p><strong>Presenter:</strong> Sebastien Sannac (Spécialiste produit spectroscopie atomique, Agilent Technologies)</p>
</blockquote>
<blockquote>
<p><strong>Presenter:</strong> Donald Inglis (Product Specialist EMEAI for FTIR, Agilent Technologies)</p>
</blockquote>
<blockquote>
<p><strong>Presenter:</strong> Remko van Loon (GC &amp; GC/MS Product Specialist, Agilent Technologies)</p>
</blockquote>


Agilent Technologies: Comprehensive Quality Control Testing of Biofuels to Ensure a Greener, more Sustainable Future

Comprehensive Quality Control Testing of Biofuels to Ensure a Greener, more Sustainable Future

Learn about the latest laboratory testing techniques that are used to ensure the quality, efficiency, and sustainability of modern biofuels.

Comprehensive Quality Control Testing of Biofuels

<p><strong>Ion chromatography (IC) hyphenated with inductively coupled plasma mass spectrometry (ICP-MS) – IC-ICP-MS is the preferred solution for speciation analyses of trace elements such as chromium, arsenic, selenium, or mercury.</strong></p><p>In this webinar we focus on some key features of the integration of Metrohm IC with Agilent’s MassHunter software for ICP-MS. Based on practical examples such as chromium speciation according to ISO 24384, we demonstrate the benefits of bi-directional communication, real-time status updates, and a single, consolidated sample list streamlining your trace elemental analysis with a single-software solution.</p><h4>Key learnings of this webinar:</h4><ul><li><strong>Learn why IC is the method of choice for the separation of ionic components for subsequent quantification with ICP-MS</strong></li><li><strong>Explore the features that make Agilent ICP-MS a superior choice for speciation analysis</strong></li><li><strong>Understand the streamlined workflow for chromium speciation according to ISO 24384 using MassHunter ICP-MS</strong></li><li><strong>Understand the added value of inline sample preparation techniques available with Metrohm IC</strong></li></ul><h4>Who should attend?</h4><ul><li>Laboratory managers, analytical chemists, researchers doing trace elemental analysis</li></ul><blockquote><p><strong>Presenter: </strong>Dr. Elke Süss (Application Specialist Ion Chromatography, Metrohm International Headquarters)</p><p>Elke Süss received a M.Sc. in Geoecology and a Ph.D. in Environmental Geochemistry in 2011 from Bayreuth University, Germany. After a position as laboratory manager at Bayreuth University, she worked as a Research Assistant and then PostDoc at ETH Zürich and Eawag focusing on trace elemental speciation and has more than 10 years of experience with IC-ICP-MS in this field. In 2018, she joined the Ion Chromatography team at Metrohm International Headquarters in Switzerland as an Application Specialist.<br>&nbsp;</p><p><strong>Presenter:&nbsp;</strong>Andrew Brotherhood (Atomic Spectroscopy Application Engineer, Agilent UK)</p><p>Andrew has over 15 years’ hands-on experience with ICP-MS, ICP-OES and Ion chromatography instrumentation. He has mainly worked in the pharmaceutical analysis industry gaining significant experience with developing and validating methods to pharma regulations.</p><p>Andrew started working for Agilent as a full-time employee in January 2018 working as an Atomic Spectroscopy Application Engineer based at the Agilent Centre of Excellence in the UK.</p></blockquote>

Metrohm: Simplify your speciation analysis: Metrohm ion chromatography meets Agilent ICP-MS

Simplify your speciation analysis: Metrohm ion chromatography meets Agilent ICP-MS

Key features of the integration of Metrohm IC with Agilent’s MassHunter software for ICP-MS.

ICPMS webinars focusing on ICP/MS - page 9