Matrix effects significantly limit accurate nanoparticle sizing in single-particle ICP-MS, often causing signal attenuation and size underestimation. This study systematically evaluates matrix-induced biases and reports up to 10 nm underestimation of Ag nanoparticle sizes due to 30–50% signal loss.To overcome these challenges, a novel online internal standard calibration strategy was developed using multielement detection and nonanalyte elements (Pd, Au) as internal standards. Simultaneous measurement of analyte and standards enabled correction of signal response and nebulization efficiency within a single run. The optimized approach provided accurate particle size determination in simulated and real matrices, extending SP-ICP-MS applicability to complex environmental and biological samples.<blockquote><h4>The original article</h4><h4><a target="_blank" rel="noopener noreferrer" href="https://pubs.acs.org/doi/10.1021/acs.analchem.5c06975">A Simple Online Internal Standard Calibration Strategy for Single-Particle Inductively Coupled Plasma Mass Spectrometry Based on Multielement Analysis</a></h4>Xiangwei Tian, Ying Wang, Peijie Yang, Dingyi Wang, Yanwei Liu, Yingying Guo, Yuning Hu*, Xiaoyan Zhang*, Ligang Hu, Yongguang Yin*, Yong Cai, and Guibin JiangAnal. Chem. 2025, 97, 51, 28139–28147<a target="_blank" rel="noopener noreferrer" href="https://doi.org/10.1021/acs.analchem.5c06975">https://doi.org/10.1021/acs.analchem.5c06975</a><h6>licensed under <a target="_blank" rel="noopener noreferrer" href="https://creativecommons.org/licenses/by/4.0/">CC-BY 4.0</a></h6></blockquote>Selected sections from the article follow. Formats and hyperlinks were adapted from the original.<div>Nanoparticles (NPs) are ubiquitous in environmental and biological systems. <a href="javascript:void(0);">(1)</a> In the environment, billions of tons of natural NPs are formed annually through biogeochemical processes. <a href="javascript:void(0);">(1)</a> Engineered NPs are widely utilized in industrial, medical, and consumer products and inevitably released into the environment. <a href="javascript:void(0);">(2)</a> In biological systems, NPs can be endogenously formed <a href="javascript:void(0);">(3)</a> or acquired from environmental exposure. <a href="javascript:void(0);">(4)</a> Functional NPs can also be intentionally delivered into biological systems as probes or drugs. <a href="javascript:void(0);">(5−7)</a> Variations in physicochemical properties of NPs, such as size and elemental composition, can influence their distribution patterns and effects within environmental and biological systems. <a href="javascript:void(0);">(8,9)</a> Therefore, it is of great significance to resolve particle heterogeneity at the single-particle level. Single particle inductively coupled plasma mass spectrometry (SP-ICP-MS), with its high-throughput and sensitive capabilities for elemental and isotopic analysis, plays a key role in single-particle analysis. <a href="javascript:void(0);">(10,11)</a>Environmental particles always exist in complex or unknown matrices, such as ice cores, <a href="javascript:void(0);">(12)</a> wastewater, <a href="javascript:void(0);">(13)</a> and seawater. <a href="javascript:void(0);">(14)</a> Biological matrices are even more intricate, typically containing high concentrations of inorganic salts and organic matter. Matrix effects pose significant challenges for SP-ICP-MS analysis of environmental and biological samples. <a href="javascript:void(0);">(15)</a> Matrix effects on ICP-MS are generally categorized into spectral and nonspectral interferences. <a href="javascript:void(0);">(15)</a> Spectral interferences arise from isobaric overlaps or polyatomic ions (e.g., ArCl+ from Cl– interfering with 75As detection), which can often be eliminated using collision/reaction cell technique. <a href="javascript:void(0);">(16)</a> Nonspectral interferences refer to matrix-induced changes in signal intensity. <a href="javascript:void(0);">(17)</a> For instance, NaCl can suppress signal intensity, whereas low concentrations of methanol may lead to signal enhancement. Changes in signal intensity further contribute to errors in mass/size measurement. It was reported that a 4.5 g L–1 NaCl matrix caused underestimation of As(0) NP and Ag NP sizes by 28% and 41%, respectively, while a 2% methanol matrix resulted in overestimations of approximately 6% and 20%. <a href="javascript:void(0);">(17)</a> Common strategies to address nonspectral interferences include sample dilution and matrix matching. <a href="javascript:void(0);">(15)</a> However, dilution pretreatments would greatly reduce the analytical throughput, and changes in matrix concentration may affect the properties or state of the analyte. In real-world samples, the matrices are always complex, making it difficult to prepare solutions with exactly the same composition for matrix matching. Isotope dilution analysis (IDA), which involves enriched isotopes of the analyte element for signal response correction, is another established approach. <a href="javascript:void(0);">(18−20)</a> Nevertheless, due to strict requirements on matrix types, isotope properties, and analyte concentrations, IDA has limited applicability to real-world sample measurements. Furthermore, among the previously reported methods, the potential influence of the matrix on particle nebulization efficiency has not been fully considered, <a href="javascript:void(0);">(18,21,22)</a> leaving quantitative uncertainties. <a href="javascript:void(0);">(17)</a> The online droplet calibration method based on the microdroplet generator and ICP-time-of-flight (TOF)-MS considers matrix effects on both signal response and nebulization efficiency; <a href="javascript:void(0);">(15,23)</a> however, the technical barriers and high cost largely limit its broader adoption. Till now, due to the lack of practical calibration methods, the characterization of NPs in real matrices typically involves laborious extraction procedures. <a href="javascript:void(0);">(24,25)</a> A need exists to develop a simple and reliable calibration strategy suitable for the measurement in the original matrix.In this study, we first systematically investigated the specific matrix effects on SP-ICP-MS and the underlying mechanisms based on the fundamentals of ICP-MS. The influence of time resolution on multielement detection was explored from multiple analytical perspectives. To address limitations of previous methods, we proposed a simple and reliable online internal standard calibration method, which largely eliminates matrix effects on size/mass determination by SP-ICP-MS. By utilizing the multielement detection mode, the signals of the analyte element(s) and internal standard elements can be monitored within the same analytical run, allowing for simultaneous correction of the response factor, nebulization efficiency, and time-dependent signal fluctuations. Notably, the novel calibration strategy involving the use a nonanalyte element as the internal standard for signal response calibration was developed and validated. The proposed method demonstrated high feasibility and reliability when applied to simulated real-world samples. It is also applicable to single-particle analysis using other types of ICP-MS (e.g., ICP-TOF-MS) and shows promise for application in single-cell ICP-MS analysis.<h4>Experimental Section</h4><h5>SP-ICP-MS Analysis</h5><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/library?mainauthorItems=10&amp;search=7900+ICP-MS">Agilent 7900 ICP-MS</a> (Agilent Technologies; Santa Clara, CA, USA) equipped with a quadrupole mass analyzer was used for SP-ICP-MS analysis. Instrument parameters are given in <a target="_blank" rel="noopener noreferrer" href="https://pubs.acs.org/doi/suppl/10.1021/acs.analchem.5c06975/suppl_file/ac5c06975_si_001.pdf">Table S2</a>. The sample introduction system was composed of syringe pumps (Leifu Fluid; Baoding, China), a Mira Mist nebulizer (Burgener; Mississauga, Ontario, Canada), and a quartz dual-channel spray chamber (Agilent Technologies; Santa Clara, CA, USA) (<a target="_blank" rel="noopener noreferrer" href="https://pubs.acs.org/doi/10.1021/acs.analchem.5c06975#fig1">Figure 1</a>). The total sample flow rates were 300 μL min–1 for all the experiments. Additionally, a more accessible introduction approach using the instrument’s integrated peristaltic pump was also tested (<a target="_blank" rel="noopener noreferrer" href="https://pubs.acs.org/doi/suppl/10.1021/acs.analchem.5c06975/suppl_file/ac5c06975_si_001.pdf">Figure S2</a>). Matrix effects on SP-ICP-MS analysis was investigated under the conventional single-element mode. The dwell time was 5 ms, with no stabilization time. The final inlet concentrations of Ag NPs and Au NPs were 50 ng L–1 (∼4.2 × 104 particles mL–1) and 25 ng L–1 (∼4 × 104 particles mL–1), respectively.<h4>Results and Discussion</h4><h5>Matrix Effects on SP-ICP-MS and the Underlying Mechanisms</h5>In the UPW matrix, the particle sizes determined by SP-ICP-MS (<a target="_blank" rel="noopener noreferrer" href="https://pubs.acs.org/doi/10.1021/acs.analchem.5c06975#fig2">Figure 2</a>A) were consistent with those measured by TEM (<a target="_blank" rel="noopener noreferrer" href="https://pubs.acs.org/doi/suppl/10.1021/acs.analchem.5c06975/suppl_file/ac5c06975_si_001.pdf">Figure S1A</a>). The most direct impact of matrix effects was observed as changes in the analyte signal intensity. Both the typical environmental and biological matrices we selected resulted in signal attenuation for the target elements. More pronounced signal attenuation was observed in the salt matrices with increasing concentration. Compared to measurements in UPW, the signal intensity of Ag NPs decreased by approximately 32% and 46% in DSW and PBS, respectively. Correspondingly, without matrix-matching correction, the particle sizes of Ag NPs were underestimated by approximately 12% and 19% in DSW and PBS, respectively (<a target="_blank" rel="noopener noreferrer" href="https://pubs.acs.org/doi/10.1021/acs.analchem.5c06975#fig2">Figure 2</a>A).<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Anal_Chem_2025_97_51_28139_28147_Figure_2_A_Particle_size_distribution_of_Ag_N_Ps_in_different_matrices_without_matrix_matching_f97e96e68c.jpeg" alt="Anal. Chem. 2025, 97, 51, 28139–28147: Figure 2. (A) Particle size distribution of Ag NPs in different matrices without matrix matching. The gray line and band denote the mean and standard deviation of the particle size determined by TEM. (B) Nebulization efficiency of Au NPs in different matrices. The letters on columns indicate the statistical difference obtained from one-way ANOVA test (p &lt; 0.05). (C) Signal intensity of standard Au NPs and AuCl4– solution in different matrices." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Anal_Chem_2025_97_51_28139_28147_Figure_2_A_Particle_size_distribution_of_Ag_N_Ps_in_different_matrices_without_matrix_matching_f97e96e68c.jpeg 245w," sizes="100vw" width="2100" height="537">Matrix-induced attenuation/enhancement of signal intensity fundamentally arise from changes in the transport efficiency of the analyte. Transport efficiency is defined as a combination of several components (<a target="_blank" rel="noopener noreferrer" href="https://pubs.acs.org/doi/10.1021/acs.analchem.5c06975#fig1">Figure 1</a>): (i) the aerosol introduction efficiency (or nebulization efficiency) from the sample introduction system (typically comprising a nebulizer and spray chamber) to the ICP torch, as calculated using <a target="_blank" rel="noopener noreferrer" href="https://pubs.acs.org/doi/10.1021/acs.analchem.5c06975#eq1">Equation 1</a>) or <a target="_blank" rel="noopener noreferrer" href="https://pubs.acs.org/doi/10.1021/acs.analchem.5c06975#eq2">2</a>); (ii) the ionization efficiency of the analyte within the ICP torch; and (iii) the subsequent extraction and transport efficiency of ions from the sampling cone to the detector.<h5>Validation of Online Internal Standard Calibration</h5><a target="_blank" rel="noopener noreferrer" href="https://pubs.acs.org/doi/10.1021/acs.analchem.5c06975#fig4">Figure 4</a>A displays the Ag NP size distribution determined when the three inlet streams (Ag NP suspension, Au NP suspension, and Pd solution) were mixed at equal flow rates (3 × 100 μL min–1). For all the matrices, the measured particle sizes showed good agreement with the actual sizes determined by TEM. Note that since both the Au NP suspension and Pd solution were prepared using UPW, the matrix containing analyte Ag NPs would be diluted upon online mixing. For real-world samples, excessive dilution could potentially change sample properties and reduce measurement throughput. To prevent excessive dilution, the calibration results were further assessed under conditions of reduced internal standard flow rates (Ag NP flow rate: 260 μL min–1; internal standard flow rates: both 20 μL min–1) (<a target="_blank" rel="noopener noreferrer" href="https://pubs.acs.org/doi/10.1021/acs.analchem.5c06975#fig4">Figure 4</a>B). Furthermore, an offline spiking approach was also tested by adding both the internal standards directly into the sample suspension (<a target="_blank" rel="noopener noreferrer" href="https://pubs.acs.org/doi/suppl/10.1021/acs.analchem.5c06975/suppl_file/ac5c06975_si_001.pdf">Figure S7A</a>). The measured sizes also agreed well with the true values. For easier access and use, online mixing using a peristaltic pump was also tested and demonstrated to accurately determine the particle sizes (<a target="_blank" rel="noopener noreferrer" href="https://pubs.acs.org/doi/suppl/10.1021/acs.analchem.5c06975/suppl_file/ac5c06975_si_001.pdf">Figure S7B</a>). The results demonstrate that neither the introduction approach and the mixing ratio affected the calibration performance, suggesting the high reliability and flexibility of the internal standard calibration method.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Anal_Chem_2025_97_51_28139_28147_Figure_4_A_B_Particle_size_distribution_of_Ag_N_Ps_in_different_matrices_measured_by_the_internal_standard_calibration_method_4ca8d3833d.jpeg" alt="Anal. Chem. 2025, 97, 51, 28139–28147: Figure 4. (A, B) Particle size distribution of Ag NPs in different matrices measured by the internal standard calibration method. (A) Flow rates of the analyte and internal standards were all 100 μL min–1. (B) Flow rates of the analyte and internal standards were 260 and 20 μL min–1, respectively. (C, D) Particle size distribution of Ag NPs in natural seawater (C) and human urine (D) matrices measured by external standard calibration or online internal standard calibration method. the flow rates of the analyte and internal standards were 260 and 20 μL min–1, respectively. The gray lines and bands denote the mean and standard deviation of the particle size determined by TEM." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Anal_Chem_2025_97_51_28139_28147_Figure_4_A_B_Particle_size_distribution_of_Ag_N_Ps_in_different_matrices_measured_by_the_internal_standard_calibration_method_4ca8d3833d.jpeg 189w," sizes="100vw" width="1433" height="1184">Further, we evaluated the performance of the proposed method in handling real biological (human urine) and environmental (natural seawater) matrices (<a target="_blank" rel="noopener noreferrer" href="https://pubs.acs.org/doi/10.1021/acs.analchem.5c06975#fig4">Figure 4</a>C and D). In addition to high salt concentrations, both matrices contain abundant organic matter, which pose challenges to accurate SP-ICP-MS analysis. Without matrix matching, the sizes of Ag NPs in both matrices were significantly underestimated. Particularly in seawater, the size was underestimated by nearly 20 nm. Using the online internal standard calibration, the median sizes of Ag NPs in diluted seawater and urine matrices were 58.9 and 58.5 nm, respectively, in close agreement with those determined by TEM. Notably, the sizes of Ag NPs in undiluted real matrices can also be accurately determined, facilitating the measurement of environmental particles in the original matrix.<h4>Conclusions</h4>In this study, we addressed the significant challenge of matrix effects in SP-ICP-MS for accurate mass/size determination in complex environmental and biological samples. We elucidated the specific matrix effects on nebulization efficiency, ionization efficiency, and ion transport. It was demonstrated that Ag NP signal intensity decreased by approximately 32% and 46% in DSW and PBS, respectively, leading to underestimated particle sizes (12% and 19%, respectively). To address these issues, we developed and validated an online internal standard calibration strategy employing multielement detection with nonanalyte elements as internal standards. By simultaneously monitoring analyte (Ag) and internal standard elements (Au for nebulization efficiency, Pd for response factor) within a single analytical run via the peak-hopping mode, we achieved real-time correction for matrix-induced variations. Optimized time-resolution conditions, particularly a 5 ms dwell time, ensured a high probability of complete event acquisition (81.8%) while minimizing particle overlapping. The measured sizes of Ag NPs in simulated (DSW and PBS) and real (natural seawater and human urine) matrices that showed good agreement with true values. The proposed method demonstrated high reliability and flexibility, regardless of the internal standard mixing ratio (e.g., 100:100:100 or 260:20:20 μL min–1), introduction approach, and sample dilution levels. In contrast to enriched isotope internal standards, which proved ineffective in anion-rich matrices due to chemical reactions, the presented nonanalyte internal standards offer enhanced adaptability across various matrices.This reliable and flexible method significantly extends the applicability of SP-ICP-MS to direct analysis of complex samples without laborious pretreatments. The potential for the measurement in the original matrix is particularly meaningful for single-cell analysis, allowing direct analysis of living cells in biological matrices. Note that the theory and method validated with Ag NPs are also applicable to the quantification of other elements in particles or cells. As a simplified alternative to the established online microdroplet calibration, <a href="javascript:void(0);">(23)</a> the proposed strategy shows great promise in the integration of advanced ICP-TOF-MS platforms for simultaneous calibration of multiple analyte elements.</div>

A Simple Online Internal Standard Calibration Strategy for Single-Particle Inductively Coupled Plasma Mass Spectrometry Based on Multielement Analysis

Valentines Day is an opportunity to show your partner (or your crush) how much they matter to you. Beyond flowers, chocolates or restaurant invites, jewelry is a popular gift for Valentines day. However, a well meant gift may turn out to even be a hazard to the giftee.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Fisher_Scientific_Cheap_Trendy_and_Toxic_High_Levels_of_Cadmium_in_Necklaces_Have_Been_Reported_Lately_93d25a7757.jpg" alt="Thermo Fisher Scientific: Cheap, Trendy – and Toxic? High Levels of Cadmium in Necklaces Have Been Reported Lately" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Fisher_Scientific_Cheap_Trendy_and_Toxic_High_Levels_of_Cadmium_in_Necklaces_Have_Been_Reported_Lately_93d25a7757.jpg 245w," sizes="100vw" width="1024" height="512">Heavy metals in jewelry, harmful chemicals in baby products: the product range offered by online marketplaces frequently fails to meet European Union safety standards. That is the alarming conclusion of recent investigations by <a target="_blank" rel="noopener noreferrer" href="https://www.spiegel.de/wirtschaft/stiftung-warentest-findet-giftige-schwermetalle-in-angeboten-von-temu-und-shein-a-efb2057b-2377-4ce4-b2e0-07be01d00df0">Stiftung Warentest</a>, Germany’s leading consumer protection organization.<h3>A reputation under scrutiny</h3>Low prices, fast fashion, and endless product choices have made online platforms hugely popular across Europe. With just a few clicks, shoppers can order clothes, accessories, toys, and electronics at prices that seem almost too good to be true.In a large-scale product test, consumer advocates found serious safety deficiencies in many popular items sold on these platforms.The advice to consumers is equally clear: buyers should dispose of affected products immediately and think carefully about what they order in the future.<h3>Shockingly high levels of toxic metals</h3>One of the most concerning findings involved fashion jewelry. In the test, the cadmium concentration in two necklaces exceeded the <a target="_blank" rel="noopener noreferrer" href="https://de.euronews.com/2025/10/31/stiftung-warentest-giftige-schwermetalle-in-shein-und-temu-produkten">EU’s legal limit by 8,500 times.</a> It´s a cheaper alternative to safer metals like silver, zinc alloys, or stainless steel, is easy to work with, and looks good at first glance.However, cadmium is classified as carcinogenic and can cause serious kidney and bone damage. Because of its toxicity, it is subject to <a target="_blank" rel="noopener noreferrer" href="https://www.bvl.bund.de/SharedDocs/Pressemitteilungen/03_verbraucherprodukte/2020/2020_02_11_PI_Modeschmuck.html">strict limits</a> in the EU. Products that exceed these limits are considered unsafe and illegal to sell.Experts strongly warn against simply throwing such items into the household trash. Jewelry contaminated with cadmium or other heavy metals should be taken to a hazardous waste collection point.The <a target="_blank" rel="noopener noreferrer" href="https://www.euroconsumers.org/systemic-failures-in-product-compliance-on-temu-and-shein/">investigation</a> covered 162 products in total of which 54 were necklaces.The products were purchased online and tested in cooperation with consumer organizations from Denmark and Belgium.The results were sobering:<ul><li>110 of the 162 products failed to meet EU safety standards</li><li>Around 25% were rated “potentially dangerous”</li></ul><h3>A broader EU problem</h3>EU authorities regularly find toxic heavy metals such as <a target="_blank" rel="noopener noreferrer" href="https://pubmed.ncbi.nlm.nih.gov/33757252/">cadmium</a>, lead, and nickel in cheap imported jewelry. These substances can trigger severe allergies, damage organs like the liver and kidneys, and increase cancer risk.Although the EU’s rapid alert system (RAPEX) removes thousands of unsafe products from the market every year, experts warn that the number of untested items is far higher than what authorities can realistically monitor.In some laboratory tests, individual jewelry items were found to consist of up to 70% cadmium, making them legally “not marketable” in Germany and the EU.The takeaway for shoppers should be clear:<ul><li>Extremely low prices can come with hidden health and safety risks</li><li>Jewelry, children’s products, and electronics deserve extra caution</li><li>When in doubt, it’s safer to buy from sellers that clearly comply with EU regulations</li></ul><h3>How can we detect Cadmium in necklaces?</h3>Consumer product/jewelry guidance explicitly notes that cadmium in jewelry extracts can be measured by ICP-OES or ICP-MS after an extraction step.Cadmium in jewelry is often regulated at low levels (either as total content after digestion or as extractable/migratable Cd in simulated-use leaches). <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/products?category=232&amp;instrumentationItems=83&amp;manufacturerItems=3">ICP-MS</a> is routinely chosen because it can quantify Cd at trace / ultra-trace levels with strong precision and accuracy.Using a Thermo Scientific iCAP MX Series ICP-MS for Cadmium (Cd) determination in necklaces/ jewellery makes sense because jewelry testing typically needs very low detection limits, high confidence in complex matrices, and defensible compliance data.<ul><li>Better interference control for Cd isotopes</li></ul>Cadmium has a range of isotopes available for analysis, but interferences need to be considered. Most isotopes are isobarically interfered by Tin (meaning that a given m/z range would be responding to both elements), the isotope typically monitored (111Cd) may be interfered by molybdenum (95Mo16O+). Since both elements can be found as well in jewelry, removing these interferences is critical to avoid false positives. The iCAP MX Series ICP-MS come with the powerful QCell collision/reaction cell to overcome interferences. The <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/products/1487">Thermo Scientific iCAP MSX ICP-MS</a> uses kinetic energy discrimination (KED) with helium gas, a generic way for reducing polyatomic interferences broadly across the mass range. The <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/products/1487">Thermo Scientific iCAP MTX ICP-MS</a> can utilize reactive gases (in many applications O2) to further improve detectability and sensitivity – a powerful asset for laboratories analysing a wide range of sample types, which on top may “messy” – i.e. containing platings, alloys, pigments, fillers, and adhesives.<ul><li>Works with recognized jewelry test workflows</li></ul>Because necklaces and other consumer products often arrive as multiple distinct batches, repeats, blanks, spikes, and QC checks must be performed. All iCAP MX &nbsp;Series ICP-MS systems are positioned for high-throughput routine trace elemental analysis, helping labs to simplify workflows and keeping uptime high—useful in contract/compliance labs.<h3>Conclusion</h3>The findings underscore a troubling reality: many ultra-cheap products sold via online marketplaces pose real health and safety risks and routinely fail to meet EU standards. From toxic heavy metals in jewelry to hazardous chemicals in baby products, the consequences for consumers can be severe. Addressing this challenge requires both stronger regulatory oversight and reliable analytical testing. Advanced techniques such as ICP-MS play a critical role by enabling laboratories to accurately detect trace contaminants like cadmium across complex samples, helping authorities and manufacturers ensure compliance. Until safeguards improve, consumers are urged to remain vigilant—because when safety is compromised, a low price is no bargain at all.<h3>Additional resources</h3><ul><li><a target="_blank" rel="noopener noreferrer" href="https://www.thermofisher.com/content/lifetech/global/en/home/industrial/mass-spectrometry/inductively-coupled-plasma-mass-spectrometry-icp-ms/quadrupole-icp-ms-systems.html">Quadrupole ICP-MS Systems</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/labrulez-bucket-strapi-h3hsga3/br_003092_tea_icp_ms_icap_mtx_discovery_br003092_em_en_e92e76f052.pdf">Ignite your confidence: iCAP MTX triple quadrupole ICP-MS</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/products/1489">Qtegra ISDS software</a></li></ul><h3>Join us for free local language webinars in 2026</h3><h5>English</h5><ul><li><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/webinar/5795">Lunch and Learn Tips and Tricks Series: Qtegra Part 1</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/webinar/5976">Lunch and Learn Tips and Tricks Series: Qtegra Part 2</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/webinar/5977">Lunch and Learn Tips and Tricks Series: Trace Elemental Analysis (ICP-OES &amp; ICP-MS)</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/webinar/5978">Trace Elemental Analysis: Ask the Expert</a></li></ul><h5>Deutsch</h5><ul><li>19. März 2026 <a target="_blank" rel="noopener noreferrer" href="https://event.on24.com/wcc/r/5179134/393E071E3B501943730958BA6203F477">Interne Standards in der ICP-OES: Ein Praxisguide für zuverlässige Qualitätssicherung im Labor</a></li><li>18. Juni 2026 <a target="_blank" rel="noopener noreferrer" href="https://event.on24.com/wcc/r/5179292/AE4C576B6A54D1AC182F7F77573D380F">Fehler reduzieren, Durchsatz steigern: Autoverdünnung mit PrepFast am ICP-MS</a></li><li>17. September 2026 <a target="_blank" rel="noopener noreferrer" href="https://event.on24.com/wcc/r/5179423/B5019C560431BADCA2A76E54E4EFE56F">ICP-OES smarter nutzen: Probendurchsatz erhöhen, Ressourcen sparen</a></li><li>17. Dezember 2026 <a target="_blank" rel="noopener noreferrer" href="https://event.on24.com/wcc/r/5179530/94EEDD1F56138F5EEE2AF24E29E6C12A">Qtegra ISDS Software Unlocked – Live im Expertengespräch</a></li></ul>Visit us on&nbsp;<a target="_blank" rel="noopener noreferrer" href="https://www.linkedin.com/showcase/72003132/admin/dashboard/">LinkedIn:</a>&nbsp;#ICP-MS #ElementalAnalysis #cadmium #TraceElementalAnalysis<section><blockquote><h5>Petra Gerhards</h5>Petra Gerhards, Dipl-Ing, is Regional Marketing Manager of GC and GC-MS for EMEA at Thermo Fisher Scientific. She has more than 29 years of experience in the fields of GC-MS, SPE and LC-MS. Since joining the regional team she has contributed to workflow solutions combining vials and closures with SPE solutions, GC-MS and LC-MS. She works with KOL's on data for regional specific marketing campaigns, organizes in-house seminars and works on customer specific solutions. Her main expertise is in the field of doping and drugs-of-abuse analysis.</blockquote></section>

Cheap, Trendy – and Toxic? High Levels of Cadmium in Necklaces Have Been Reported Lately

Our Library never stops expanding. What are the most recent contributions to LabRulezICPMS Library in the week of 23rd February 2026? Check out new documents from the field of spectroscopy/spectrometry and related techniques!<blockquote>👉 <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/library">SEARCH THE LARGEST REPOSITORY OF DOCUMENTS ABOUT SPECTROSCOPY/SPECTROMETRY RELATED TECHNIQUES</a></blockquote><blockquote>👉 Need info about different analytical techniques? Peek into <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/library">LabRulezLCMS</a> or <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library">LabRulezGCMS</a> libraries.</blockquote>This week we bring you application notes by Agilent Technologies, Metrohm, Shimadzu and Thermo Fisher Scientific!<h3>1. Agilent Technologies: UV-Vis Spectroscopy for Quality Assessment of Paprika as per ASTA Method 20.1</h3>From sample prep to analysis using the <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/library?mainauthorItems=10&amp;search=Cary+3500">Agilent Cary 3500 Multicell UV-Vis</a><ul><li>Application note</li><li><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/labrulez-bucket-strapi-h3hsga3/an_paprika_uv_vis_cary_5994_8612en_agilent_d903914b39.pdf">Full PDF for download</a></li></ul>Paprika is a widely used spice valued for its deep red color and characteristic flavor, contributing to its prominence in both culinary and commercial applications. As a high‑demand commodity produced from dried capsicum pods, paprika is subject to quality variation and adulteration, which can compromise product authenticity, consumer trust, and regulatory compliance. UV-Visible (UV-Vis) spectroscopy is a rapid, reproducible analytical technique for evaluating paprika quality by quantifying pigment concentration. In paprika, color intensity primarily arises from carotenoid compounds, and is commonly assessed using the ASTA Method 20.11 – a well-established industry standard that commercially grades paprika samples as a numerical ASTA color value.In this application note, we used an <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/library?mainauthorItems=10&amp;search=Cary+3500">Agilent Cary 3500 Multicell UV-Vis spectrophotometer</a> and <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/library?mainauthorItems=10&amp;search=UV+Workstation+software">Agilent Cary UV Workstation software</a> to determine the ASTA color value of two commercial paprika samples. The measurements were performed in accordance with ASTA Method 20.1 for the determination of extractable color in capsicums and their&nbsp;oleoresins.<h4>Results and discussion</h4><h5>Paprika samples' analysis&nbsp;</h5>ASTA Method 20.1 measures the color intensity of paprika by extracting pigments with acetone and recording absorbance at 460 nm. The absorbance reading, along with sample weight is then used to calculate the ASTA color value. The ASTA color value is a crucial quality parameter for paprika and other spices, as it indicates the intensity and vibrancy of the red color, which is a key characteristic for consumers and food manufacturers. In this study, the two extracted paprika samples were each measured three times to produce triplicate results (Table 4). Sample 1 had a corrected ASTA color value of approximately 103, and sample 2 had a corrected ASTA color value of approximately 61, indicating a lower color intensity. The corrected ASTA color value was automatically generated in an easy-to-read table of values, and a scan report was automatically exported into a user-defined location.<h4>Conclusion&nbsp;</h4>The Agilent Cary 3500 Multicell UV-Vis spectrophotometer with Agilent Cary UV Workstation software enabled fast, reliable, and standardized quality assessment of paprika samples. Using the well-established industry method, ASTA 20.1, the Cary 3500 system provided precise quantification of carotenoid pigments, supporting grading categorization. The high-throughput multicell design of the Cary 3500 Multicell UV-Vis spectrophotometer allows simultaneous measurement of up to seven samples and a reference, improving efficiency and minimizing variability. The Cary UV Workstation software simplifies data acquisition and analysis with intuitive spectral features such as the End of sequence analysis tool, which can be applied automatically to any scan method, and spectra comparisons through the Load spectrum tool. From sample absorbance measurement to final reporting, the Cary 3500 system eliminated the need for manual data processing or external tools, minimizing complexity and facilitating confidence.<h3>2. Metrohm: NIRS analysis of forages</h3>Multiparameter determination in a few seconds<ul><li>Application note</li><li><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/labrulez-bucket-strapi-h3hsga3/an_nir_131_download_2f897ff7f5.pdf">Full PDF for download</a></li></ul>Forages are plants or parts of plants eaten by both livestock and wildlife. Forages provide bulk, help with weight maintenance, and combat several issues [1]. Alfalfa forage is high in protein—well-suited to promote muscle mass in beef cattle or to increase the production of dairy cows [2]. Alfalfa is also commonly used for horse feed. These animals require forages with good palatability along with high digestibility, intake potential, and protein levels, thus increasing the demand for alfalfa and other high-quality feeds. Farmers have responded by producing even higherquality alfalfa in recent years. Since forage quality depends on chemical, biological, and dynamic properties, both measured and calculated methods must be used. Standard alfalfa assays measure neutral detergent fiber (NDF), acid detergent fiber (ADF), crude protein (CP), ash, moisture, and protein. For alfalfa pellets, the mean particle size is also important. Near-infrared spectroscopy (NIRS) offers rapid and reliable prediction of fat, moisture, crude protein, fiber, ash and starch in a few seconds and without sample preparation.<h4>EXPERIMENTAL EQUIPMENT</h4>Samples of alfalfa (including fresh alfalfa, alfalfa pellets, and alfalfa cubes) were analyzed on a <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/library?mainauthorItems=220&amp;search=NIR+Analyzer">Metrohm NIR Analyzer</a>. All measurements were performed in reflection mode using the large cup. The samples were measured in rotation to collect spectral data from several areas. Spectral averaging of signals from several spots helped to reduce sample inhomogeneity. The reference values were measured according to ISO norms described at the end of this Application Note. Metrohm software was used for all data acquisition and prediction model development.<h4>CONCLUSION&nbsp;</h4>This Application Note demonstrates the feasibility to determine multiple key parameters of alfalfa forage with NIR spectroscopy. Several analytical methods are usually required to measure key quality parameters for forage (Table 4). NIRS forage analysis enables a highly accurate, cost-effective, and fast alternative.<h3>3. Shimadzu: Analysis of Heavy Metals in Baby Food Using ICP-MS</h3><ul><li>Application note</li><li><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/labrulez-bucket-strapi-h3hsga3/an_01_01039_en_c563bb1b82.pdf">Full PDF for download</a></li></ul><h4>User Benefits</h4><ul><li>Heavy metals in various baby foods can be analyzed simultaneously with sufficient sensitivity.</li><li>Stable analysis can be performed even for baby foods with high matrix content.</li><li>Using the standard LabSolutions ICPMS rinse function, the time to clean the sample introduction system is minimized, which prevents carryover.</li></ul>Infants’ metabolic pathways are still developing, and because of their lower body weight, they are known to be more susceptible to the effects of harmful substances. In the United States, the Baby Food Safety Act 20211), and in the EU, Commission Regulation (EU) 2023/9152) and Commission Regulation (EU) 2024/19873) require the control of toxic metals contained in baby foods. ICP-MS is suitable for the analysis of trace amounts of toxic metal elements because it can perform multi-element simultaneous analysis with high sensitivity.However, baby foods vary in matrix composition, which raises concerns about non-spectral interferences and long-term stability during ICP-MS analysis. This Application News describes the analysis of five baby foods with different matrices using the <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/library?mainauthorItems=1&amp;search=ICPMS-2040%2F2050">ICPMS-2040/2050</a> (Fig. 1). Additionally, spike recovery tests and long-term stability were assessed based on the Food and Drug Administration (FDA) Elemental Analysis Manual (EAM) Section 4.74).<h4>Equipment Configuration and Analysis Conditions&nbsp;</h4>The equipment configuration is shown in Table 2. To reduce running costs, a mini-torch with lower argon gas consumption compared to conventional torches was used for analysis. Additionally, to streamline sample preparation, an Online Internal Standard Kit was utilized for online addition.&nbsp;The analysis conditions are detailed in Table 3. After analyzing high-concentration samples, the sample introduction system can influence the analysis values of subsequent samples (carryover). If carryover occurs, re-measurement is necessary, which consumes additional time and samples. With LabSolutions ICPMS, rinse solutions can be set for each sample, enabling effective cleaning in minimal time. Normal cleaning was performed using pure water (Rinse solution 1), and an additional acid rinse solution (Rinse solution 2) was introduced only after high-concentration samples.For example, Table 4 shows the difference in carryover concentration when measuring a blank sample after introducing a sample with a CCV concentration, comparing the case where rinse solution 2 is added for an additional 240 seconds to the case where it is not. Among the elements measured this time, Se and Hg tend to have a higher risk of carryover, but by introducing rinse solution 2, carryover was reduced to below the detection limit. Moreover, even if unexpectedly high-concentration samples are introduced, the Extended Rinsing function allows for automatic additional rinsing (Fig. 3). This eliminates the need to repeatedly check analysis values or to set a uniform cleaning time uniformly, thus reducing the verification effort, the amount of rinse solution required, and the analysis time while preventing carryover.&nbsp;Furthermore, to minimize time spent cleaning the sample introduction system, ProActive Rinsing was used (Fig. 4). When measuring multiple samples, starting the rinse in advance during measurement reduces the measurement time for subsequentsamples.<h4>Conclusion&nbsp;</h4>In this Application News, elemental analysis of baby food was conducted using the ICPMS-2040/2050. We achieved detection limits that met stringent standards. The spike recovery tests yielded good results for all samples with different matrices, confirming the validity of the analysis. Additionally, we analyzed 50 samples of infant formula with a high matrix over approximately six hours and confirmed good stability. The ICPMS-2040/2050 offers high sensitivity, accurate analysis, and good stability. Its Extended Rinsing and ProActive Rinsing functions effectively clean the sample introduction system, preventing carryover. Therefore, the ICPMS-2040/2050 is a suitable instrument for elemental analysis in baby food.<h3>4. Thermo Fisher Scientific: Food protection methods assessed by Surface Enhanced Raman Spectroscopy</h3><ul><li>Application note</li><li><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/labrulez-bucket-strapi-h3hsga3/food_protection_methods_surface_enhanced_raman_spectroscopy_an54670_en_5c5e701389.pdf">Full PDF for download</a></li></ul>Lipid oxidation is a major issue for the meat industry as it can not only affect&nbsp;sensory quality in terms of flavor and odor but can also lead to the formation of toxic compounds such as malondialdehyde (MDA) and cholesterol oxidation products, as well as the accumulation of carbonyls, alcohols and volatile acids. The degree of oxidation depends on various factors such as the type of meat, the fat content, the storage temperature, the availability of oxygen and the type of packaging1, 2. To prevent oxidation, synthetic antioxidants are commonly added to meat products, but consumers are now demanding more natural products3. Several studies have been carried out to evaluate the antioxidant activity of many essential oils or extracts from plants or spices such as rosemary, cinnamon or oregano, and the new trend is to develop innovative packaging by adding these natural antioxidants directly to the packaging materials4–6. These materials, often films, are known as “active packaging” because they enable the controlled release of active agents either on the surface or in the internal atmosphere of the product, or by trapping the radicals responsible for harmful effects on food quality. However, the antioxidant performance of these films must be accurately determined to enable the selection of the right packaging for each foodstuff.&nbsp;Among all the techniques available, Raman spectroscopy is a promising candidate for detecting most molecular species with high specificity and sensitivity, particularly in the presence of Surface-Enhanced Raman Scattering (SERS). Indeed, SERS is a physical phenomenon that occurs in the presence of a rough nano-structured metallic surface that causes the intensification of Raman signals from molecules adsorbed to the surface thanks to the combination of a chemical effect and an electromagnetic effect7 . The metals used are generally gold or silver, which can be prepared by electrochemical roughening, metallic coating, or deposition of nanoparticles (often in a colloidal form). Commercial solutions are available, but many researchers prefer to create their own SERS substrates. The scope of this work is to investigate the potential of a home-made SERS substrate to compare the lipid oxidation over time in ground pork preserved either in a low-density polyethylene (LDPE) conventional packaging or in an active packaging containing oregano extract.<h4>Material and method&nbsp;</h4>Fresh ground pork meat was purchased in bulk from a local supermarket and 22 g samples of meat were placed in 5-cm diameter polystyrene Petri dishes. Each sample was covered with an active film and packed in an LDPE bag under a normal atmosphere. Reference samples were also prepared using conventional LDPE films. All samples were stored in a refrigerator at 5 °C and their lipid extracts were analyzed after 0, 7, 9, 11, 14 and 16 days using a home-made SERS substrate based on silver nanoparticles deposited on a glass Petri dish. A special home-made cooling system was used to perform the analyses at low temperature and SERS spectra were measured at -2 °C on a <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/products/2239">Thermo Scientific™ DXR3 Raman Microscope</a> (Waltham, MA, USA) with a 532 nm laser source, a 900 lines/mm grating covering the 50-3500 cm-1 spectral range and an x10 objective (NA 0.40). The laser power was set at 5&nbsp;mW, and 20 exposures of 30 s each were selected to acquire all data. Thermo Scientific™ OMNIC™ v. 9.2 software was used for data collection and analysis. All the measurements were performed in triplicate. As the decrease in the peak at 1655&nbsp;cm-1 (stretching of C=C bonds from unsaturation) can be attributed to lipid peroxidation, and the 1439 cm-1 (scissoring deformation of CH2) is not affected by it, the area ratio between 1655 cm-1 and 1439 cm-1 bands was calculated to follow the lipid oxidation.<h4>Conclusion&nbsp;</h4>The effectiveness of a home-made SERS substrate coupled with a home-made cooling system was demonstrated for monitoring lipid oxidation in packaged ground pork meat over time. The advantages of this technique are its speed and the minimal sample handling requirements. An improvement factor of the order of 107 over conventional Raman was observed. This study also confirmed the greater efficacy of active packaging containing oregano extracts against lipid oxidation in ground pork, compared to conventional LDPE packaging.

News from LabRulezICPMS Library - Week 09, 2026

Article

Product

Application

Health

Scientific article

Science and research

Video

A unique company dedicated to serving science helping our customers drive productivity and accelerate results. Through our premier brands – Thermo Scientific, Applied Biosystems, Invitrogen, Fisher Scientific and Unity Lab Services.

Thermo Fisher Scientific

Everything from the world of analytical chemistry in one place. We connect people in solving their problems. At Labrulez you will find all the necessary information easily, quickly and clearly. Stop searching and start finding.

LabRulez

Agilent Technologies

SciY/Mestrelab Research

Waters Corporation

Extractables and leachables (E&amp;Ls) analysis is challenging and requires complete confidence in the results to ensure regulatory compliance. No single analytical tool can analyze all E&Ls; we offer diverse analytical technologies and expertise for the accurate identification and quantification of potential E&amp;Ls.
In this webinar our experts will discuss current regulatory updates, holistic and comprehensive analytical workflow strategies for quick scouting, profiling &amp; quantification of wide spectrum E&amp;L impurities and answer any questions you may have.
<h3>You would learn:</h3>
<ul>
<li>Regulatory updates on Extractables &amp; Leachables;</li>
<li>Overall comprehensive approach &amp; strategies to screen, detect, identify &amp; quantify Extractable &amp; Leachable compounds in various Pharma &amp; Biopharmaceutical drugs;</li>
<li>Analytical Technologies portfolio &amp; decision making software for complex studies of targeted &amp; non-targeted Extractables &amp; Leachables.</li>
</ul>
<h3>Who should attend:</h3>
<ul>
<li>Extractables &amp; Leachables analysts and laboratory managers; </li>
<li>Researchers interested in Extractables &amp; Leachables studies in Pharma/Biopharma/Medical Device/Polymer Manufacturing/CRO’s/CMO’s and others;</li>
<li>Analysts performing untargeted analyses including drug impurity profiling;</li>
<li>Quality Assurance experts in the above industries.</li>
</ul>
<blockquote>
Presenter: Antonio Chana (Product Specialist Liquid Phase Separation, Agilent Technologies)
</blockquote>
<blockquote>
Antonio Chana, Ph. D. in chemistry and Agilent product specialist in liquid phase separation for Spain and Portugal. He joined Agilent from the pharmaceutical industry where he has held positions of analytical development manager, QC manager and laboratory manager among others.
</blockquote>
<blockquote>
Presenter: Zainul Abid CKV (Product Specialist - Spectroscopy, Agilent Technologies)
</blockquote>
<blockquote>
Dr Zainul Abid is a product specialist with Agilent Technologies India Pvt Ltd based in Bangalore. He has several years of research and application development experience in Molecular spectroscopy domain. His expertise includes infrared spectroscopy and imaging, Raman spectroscopy and imaging, UV-Vis and NIR spectroscopy etc. He actively works with different industry experts to set up high-end spectroscopy laboratories.
</blockquote>
<blockquote>
Presenter: Soma Dasgupta (PhD Application Engineer, GC/GCMS, Agilent Technologies)
</blockquote>
<blockquote>
Soma received her PhD from the University of Pune, India and joined Agilent in 2016 and specializes in areas including multi-residue method development; pesticides and environmental applications and genotoxic impurities in pharmaceuticals. Prior to joining Agilent Technologies, she performed her doctorate research at the University of Pune in conjunction with the National Research Centre for Grapes where she concentrated on developing comprehensive methods for analysis of agro-chemicals in fruits and vegetables. She has worked with Thermo Fisher Scientific as Application Specialist for GC and GC-MS. Once joining Agilent, she is responsible for solutions meet our customers&#39; analytical needs. Her specialties include multi-residue method development; pesticides and environmental applications and genotoxic impurities in pharmaceuticals. She has more than 25 publications in peer-reviewed journals and application notes to her credit and a book chapter as well.
</blockquote>
<blockquote>
Presenter: Prasanth Joseph (Presales Application Engineer- LCMS, Agilent Technologies)
</blockquote>
<blockquote>
Prasanth Joseph is working as Application Engineer at Agilent Center of Excellence, Bangalore. He is having more than 16 years of experience in handling LC-MS/MS for various small molecule applications.His expertise includes MRM based screening and quantitation of various chemical residues in food commodities and pharma applications such as impurity profiling, genotoxic impurity quantitation and analysis of extractables and leachables in various packaging systems.
</blockquote>
<blockquote>
Presenter: Vinay Jain (COE Manager, Agilent Technologies)
</blockquote>
<blockquote>
Dr Vinay Jain, working as COE Manager and ICP-MS Application Scientist at Agilent Technologies India. He is Ph.D. on analytical chemistry. He has more than 30 years of analytical and research experience in spectroscopic techniques (LC-ICPMS, GC-ICPMS, ICP-MS QQQ, ICP-MS, ICP-OES, AAS, XRF, XRD) and expertise in various market segments such as Pharma, Food &amp; Farm products, Packaging, Chemical, Clinical, Environment, Petroleum, Ayurveda &amp; Herbal. His area of specialization includes new analytical method development and validation as per regulatory guidelines. He has completed more than 28 research projects with various research and regulatory organizations, of national and international importance. He is having two patents, six research paper publication; two chapters in various international handbooks and five Agilent application notes in his credit. Received TechInnovation Award in 2020 from Agilent Technologies India.
</blockquote>

Agilent Technologies: Mitigating the Risk of Extractables & Leachables Analysis - Regulatory Updates & Analytical Workflow Strategies

Mitigating the Risk of Extractables & Leachables Analysis - Regulatory Updates & Analytical Workflow Strategies

Do you think time-consuming tasks in ICP-MS are inevitable? Something that has to be accepted as part of routine operations? Find out how ICP-MS 7850 helps you easily meet your analytical requirements while simplifying laboratory workflow and improving performance and satisfaction for analysts and laboratory managers.
The intelligence embedded in the ICP-MS 7850 provides a more efficient way to perform metal analysis by reducing unnecessary wasted time so that your staff can focus on activities that generate greater value for the laboratory.
<h5>WHAT YOU WILL LEARN:</h5>
<ul>
<li>Simplify the preparation of your samples and standards</li>
<li>Facilitate the implementation of analytical methods and the handling of the instrument</li>
<li>Improve confidence in your results whatever the matrix analyzed</li>
<li>Maintenance operations and reduce instrument downtime</li>
<li>Optimize and obtain better instrument and samples’ insights</li>
</ul>
<blockquote>
Presenter: Dr. Raimund Wahlen (Product Specialist, Agilent Technologies, Inc., USA)
</blockquote>

Agilent Technologies: The new Agilent 7850 ICP-MS - Free your workflows from common time traps 

The new Agilent 7850 ICP-MS - Free your workflows from common time traps 

The smarter way to avoid time traps in your laboratory.

Agilent 7850 ICP-MS - Free your workflows from time traps 

After two introductory webinars to the tool presented by our colleague Dr. Gary Sharman, we wanted to continue this Mnova Gears webinar series by sharing more in-depth use cases. Different users from big and small Pharmas and Universities will be telling us how they have automated their analytical data workflows using Mnova Gears.
<h3>ABSTRACT</h3>
To streamline the workflow of the analytical data processing, data reporting and management of registered compounds in our SMDI database, we have collaborated with Mestrelab Research over the past two years to build an efficient and automated workflow using Mgears and other Mnova software. In this new workflow, the 1D/2D NMR and LCMS raw data from multiple instruments (Bruker, Agilent, and Thermo) are detected in real-time and paired with the expected chemical structure.
Next, the NMR data are processed and analyzed (FT transform, phase/baseline correction, peak picking and multiplet analysis etc.), and together with the LCMS data, the proposed structure is verified by comparing the expected molecular ion and isotope pattern, the predicted NMR spectra and peak assignments.
The results are reported in one document in a predefined format for both NMR and LCMS. Then, the reports are saved to a Mnova DB and Genentech SMDI database.
This process happens in real-time without human intervention. Currently the system is running constantly 24/7 serving users who have access to the SMDI database. All users can easily retrieve the reports from SMDI data browser or by searching the Mnova DB. After user reviewing and revising in Mnova, the reports can be saved back to the databases.
<h5>What to expect</h5>
A demonstration of how Mnova Gears was set up and run at Genentech’s labs.
<h5>Key points</h5>
<ul>
<li>Mnova Gears effectively streamlines the workflow of analytical data processing and reporting</li>
<li>Mnova Gears creates “live” and interactive analytical data reports in SMDI, Genentech’s database</li>
<li>“Live” analytical data reports stored in Mnova DB make retrieving old analytical data for review and publication much easier</li>
</ul>
<h5>Who should attend?</h5>
Scientists in pharma, biotech and other fields who want to automate NMR and LCMS data processing and reporting.
<blockquote>
Presenter: Yanzhou Liu (Scientific Manager, Genentech)
</blockquote>
<blockquote>
I have been working in pharmaceutical industry as a medicinal chemist and NMR spectroscopist for more than 20 years. Currently, I manage the NMR facilities in Discovery Chemistry Department at Genentech.
</blockquote>

Mestrelab Research: Using Mnova Gears to Automatically Process and Report NMR & LC/MS Data in Real-Time at Genentech

Using Mnova Gears to Automatically Process and Report NMR & LC/MS Data in Real-Time at Genentech

Automated real-time processing of NMR & LC/MS using Mnova Gears at Genentech.

Using Mnova Gears to Automatically Process and Report Data

Three-day virtual workshop covering USP methods from sample preparation to report generation, all in an environment where you can interact with peers and application experts from Agilent, who will be there to answer all your analytical questions.
You will Learn:
<ul>
<li>USP Analysis
</li>
<li>Sample Preparation considerations
</li>
<li>CFR Part 11 Compliance Solutions
</li>
<li>Compliance Setup
</li>
<li>Requirements and Techniques for Measuring Tough Samples
</li>
<li>Tips to Achieve the Highest Productivity
</li>
<li>Standard and QC Preparations
</li>
<li>Data Analysis &amp; Processing
</li>
<li>Report Generation and Customization
</li>
</ul>
<blockquote>
Presenter: Bert Woods (Application Scientist, Agilent Technologies, Inc.)
</blockquote>
<blockquote>
Joined the Agilent ICP-MS team in 2004, with previous employment in the semiconductor industry with Dominion Semiconductor (IBM/Toshiba) and Micron. Bert is a 1997 Chemistry graduate of Radford University in Virginia and an avid Washington DC Sports fan.
</blockquote>
<blockquote>
Presenter: Ana Garcia-Gonzalez (Atomic Spectroscopy Applications Scientist, Agilent Technologies, Inc.)
</blockquote>
<blockquote>
Ana Garcia is the Atomic Spectroscopy Application Scientist at Agilent Technologies, Inc. Ana has a broad background in atomic spectroscopy technologies, including international experience developing and validating analytical spectroscopy methods for the geochemical industry. She has also published in the fields of molecular spectroscopy and chemometrics. Ana holds a MSc in plant Biotechnology at CINVESTAV, México, and a Bachelor of Science in Biotechnology Engineering.
</blockquote>
<blockquote>
Presenter: Abe Gutierrez (ICP-MS Product Specialist, Agilent Technologies, Inc.)
</blockquote>
<blockquote>
Abe Gutierrez was born and raised in beautiful Arecibo, Puerto Rico. He attended the University of Puerto Rico at Mayaguez Campus. His first experience with ICP-MS came while he was an Analytical Chemist at Ashland Chemicals in Dallas, TX. In Ashland Chemicals, Abe’s team developed new methodology that included the use of ETV-ICP-MS, Membrane Desolvation and Ultrasonic Nebulizers for semiconductor applications. His passion for sample introduction systems helped him moved to a job as a Research Chemist with Cetac Technologies in Omaha Nebraska. At Cetac he helped with the development of the sample introduction systems for the HP/Agilent ICP-MS. While at Cetac, Abe also performed demos and ran samples for Agilent; a couple of years later he joined the HP/Agilent team in the US as an Applications specialist.
</blockquote>
<blockquote>
Abe has changed roles from applications to sales support but he remains part of Agilent’s Field Advisory Team working with R&amp;D, applications chemists and the manufacturing site to help with the introduction and implementation of new and revolutionary technology. Abe is now the ICP-MS Product Specialist for the eastern part of the United States and he lives in South Florida with his wife and 4 kids.
</blockquote>
<blockquote>
Presenter: Chris Conklin (Atomic Spectroscopy Product Specialist, Agilent Technologies, Inc.)
</blockquote>
<blockquote>
With a degree from the University of Wisconsin – Eau Claire, Chris worked in, and lead, a quality control lab testing fine chemicals ranging from reagent grade to high purity. Over the course of 12 years in that role, Chris has run a variety of atomic elemental instruments and techniques including AA, ICP-OES, and ICP-MS. As a result, he has seen most of the periodic table in its elemental form and overcome the associated interferences. In 2018, Chris brought that knowledge and experience to his current role with Agilent as the Product Specialist for Atomic Spectroscopy supporting AA, MP-AES, and ICP-OES for the Eastern US.
</blockquote>

Agilent Technologies: USP 232/233 Elemental Impurities Analysis Part 1: Why USP and what laboratories need to be Ready and Successful

USP 232/233 Elemental Impurities Analysis Part 1: Why USP and what laboratories need to be Ready and Successful

Three-day virtual workshop covering USP methods from sample preparation to report generation.

USP 232/233 Elemental Impurities Analysis Part 1

Agilent Technologies: USP 232/233 Elemental Impurities Analysis Part 2: The Compliance Toolbox - Tools to facilitate compliance and understanding FDA requirements, User responsibilities and Agilent solutions

USP 232/233 Elemental Impurities Analysis Part 2: The Compliance Toolbox - Tools to facilitate compliance and understanding FDA requirements, User responsibilities and Agilent solutions

USP 232/233 Elemental Impurities Analysis Part 2

Agilent Technologies: USP 232/233 Elemental Impurities Analysis Part 3: Bring it all together with Hardware and Software Live Demo for USP analysis.

USP 232/233 Elemental Impurities Analysis Part 3: Bring it all together with Hardware and Software Live Demo for USP analysis.

USP 232/233 Elemental Impurities Analysis Part 3

The pharma industry is undergoing constant evolution, requiring implementation of more efficient process while experiencing more stringent regulatory requirements.
The ability to be fast to market, while maintaining a strong understanding of your product, is critical.
At Agilent, we understand your analytical requirements.
<h3>Thursday, 18th February - Live Broadcast</h3>
<h5>1. 10:15 a.m. – 11:15 a.m. CET The fundamentals of dissolution</h5>
<blockquote>
Presenter: Owain McKenzie (EMEA Dissolution Business Team Manager, Agilent Technologies)
</blockquote>
<h5>2. 12:00 p.m. – 01:00 p.m. CET Minimize Regulatory Risk by moving to a Customized Instrument Qualification Solution</h5>
<blockquote>
Presenter: Garry Wright (European Laboratory Compliance Specialist, Agilent Technologies)
</blockquote>
<h5>3. 03:00 p.m. – 04:00 p.m. CET Dissolution best practices and qualification</h5>
<blockquote>
Presenter: Owain McKenzie (EMEA Dissolution Business Team Manager, Agilent Technologies)
</blockquote>

Agilent Technologies: Agilent 1st Pharma Virtual Symposium

Agilent Pharma Virtual Symposium - Day 2

We are pleased to invite you to the 1st Agilent Lab Informatics Virtual Summit.
During the course of our summit, there will be talks from Agilent experts, live interactive Q&amp;A, software demonstrations as well as a virtual exhibition.
Stay up to date with the latest trends and developments in Laboratory Informatics!
<h3>Topics include:</h3>
<ul>
<li>An Ecosystem for a Digital Lab – Aspects and Possibilities</li>
<li>Cloud Solutions</li>
<li>Data Integrity</li>
<li>Laboratory Information Management System (Agilent SLIMS)</li>
<li>Chromatography Software</li>
<li>Scientific Data Management Systems</li>
<li>Computer System Validation</li>
</ul>
Keep your knowledge about the evolving landscape of scientific software up to date. Whether you are planning to introduce a new system in your lab soon, or you are currently happy with your system, you will learn something important and will be much better informed after visiting this exciting event.
We will have an exhibition where you can visit various booths to learn more about our latest products and solutions. Our booth team will be there for you virtually from 08:00 a.m. – 05:00 p.m. CET; to answer any questions through a convenient chat-box option or via a private video chat.

Agilent Technologies: 1st Agilent Lab Informatics Virtual Summit

1st Agilent Lab Informatics Virtual Summit

From the everyday consumer to scientists in the laboratory, we all rely on accurate information to make critical decisions.
Waters Corporation is pleased to bring together chromatography thought leaders for a week of scientific talks, live demonstrations, panel discussions, and networking regarding novel liquid chromatography technologies and applications.
Join us for this virtual symposium beginning with a plenary session on Monday, March 22nd and followed by application sessions for Pharma, Food, Materials and Biomedical Research throughout the week!
<h3>THURSDAY, MARCH 25, 2021</h3>
<h3>Morning Session - 5:00 - 6:30pm CET</h3>
<h4>Accelerating Materials Innovation with Modern Separations Technologies</h4>
Intense pressures from consumers and regulatory bodies for safer, more sustainable, and higher-performing materials require precise analytical and measurement tools that help secure a first-to-market advantage and adhere to critical regulations by providing deep insights into polymer specimen quickly, efficiently, and with a high degree of reliability. This session will provide a series of talks on polymer separation techniques and capabilities.
<h4>Presentations:</h4>
<h5>1. Welcome/Introduction (Bryan Katzenmeyer, Ph.D., Waters Corporation)</h5>
<blockquote>
Presenter: Bryan Katzenmeyer, Ph.D. (Senior Manager, Materials Science, Waters Corporation)
</blockquote>
<blockquote>
Bryan Katzenmeyer has over 10+ years of experience specializing in mass spectrometry and separation techniques for the characterization of materials, polymers, monomers, and small molecules as well as increasing leadership roles within technical organizations. He currently oversees the Americas Materials Science business marketing segment for Waters Corporation. The Materials Science business market focuses on polymers, fine and specialty chemicals, extractables/leachables, medical device testing, cosmetics and personal care products, fuel/energy, and agrochemicals. Prior to joining Waters, Bryan was an Analytical Group Leader and Senior Scientist at Valspar (now part of Sherwin-Williams). While here he managed the liquid chromatography and mass spectrometry team focused on developing and validating analytical methodologies to characterize extractables and leachables, resins, oligomers, monomers, and other small molecules in packaging coatings for the food and beverage industries. Bryan received his Ph.D. in Polymer-Analytical Chemistry at The University of Akron working under Distinguished Professor Chrys Wesdemiotis. Here, he researched interfacing liquid chromatography and ion mobility separation with multi-dimensional mass spectrometry for the structural characterization of polymeric materials. He also obtained a M.S. in Chemistry from the University of Wisconsin-Madison and a B.S. in Chemistry from Penn State University. 
</blockquote>
<h5>2. Multi-Detector Size Exclusion Chromatography: Accelerating Innovation Through Greater Insight Into Polmer Performance Properties</h5>
<blockquote>
Presenter: Amandaa Brewer, Ph.D. (Senior Research Scientist, Arkema)
</blockquote>
<blockquote>
Amandaa K. Brewer received her Ph.D. in Analytical Chemistry in 2010 from Florida State University (FSU) and her B.S. in Chemistry from Roanoke College in 2005. Her Ph.D. thesis was under Andre Striegel and titled “Multi-Detector Hydrodynamic Chromatography: Particle Characterization and Ultra-High Molar Mass Polymer Analysis.” From 2011 to 2015 she worked at Tosoh Bioscience LLC, where she was first the GPC Technical Specialist and later advanced to the GPC Sales Support Leader. In May 2015 Amandaa joined Arkema Inc., at their North America Research and Development site in King of Prussia, Pennsylvania. She is currently a Senior Research Scientist in the Analytical and Systems Research Group at Arkema and heads the Gel Permeation Chromatography Laboratory. Her research interests are in the area of macromolecular characterization, in particular in using structure-property relationships obtained by multi-detector size-based separations techniques to aid in the understanding of end-product performance and applications as well as the characterization of ultra-high molar mass polymers and applying multi-detector hydrodynamic chromatography to industrial applications. Amandaa is the author of peer-reviewed publications focusing in the area of size based separation methods such as size-exclusion and hydrodynamic chromatography coupled to multi detection methods, namely multi-angle light scattering, quasi-elastic light scattering, differential viscometry, and differential refractometry. She has also published an encyclopedia article on gel-permeation column packing material and lectured in the area of multi-detector size-exclusion chromatography.
</blockquote>
<h5>3. Expanding Detection Capabilities in SEC and APC: On-line SEC-ICP/MS and APC-ICP/MS Hyphenation</h5>
<blockquote>
Presenter: Miroslav Janco, Ph.D. (Senior Research Scientist, Dow)
</blockquote>
<blockquote>
Dr. Miroslav Janco is a senior research scientist and a Polymer Separations GTN leader within the Analytical Science team of the Core R&amp;D organization at Dow Chemical. He holds a M.S. with honors in Chemical Engineering from the Institute of Fine Chemical Technology in Moscow, Russia and a Ph.D. in Macromolecular Chemistry from the Polymer Institute of the Slovak Academy of Sciences in Bratislava. His extensive career in the field of separation science and analytical chemistry was built in renowned laboratories around the word including Osaka University (Japan), University of California—Berkeley, Hahn-Meitner Institute (Berlin, Germany), and the University of Torino (Italy) where he developed a unique LC CAP-NMR hyphenated technique for the separation of polymers by tacticity, fast polymer separations by HPLC on monolithic columns and applied LC CAP for separations of block copolymers, respectively. Currently, his research is focused on the separation and characterization of polymers on both particle and molecular levels by HDC and LC, including SEC, HPLC, LC CAP modes using conventional (RI, UV, ELSD) and enhanced (LS, VIS, ICP/MS, MALDI and NMR) detections as well as coupled (2D-LC) and hyphenated (LC-ICP/MS and LC-NMR) techniques. Dr. Janco has authored or coauthored 26 original scientific papers in peer-reviewed journals and presented his research at more than 60 international conferences. His latest contribution to the field of polymer separation and characterization is development of Ultra-High Pressure Size Exclusion Chromatography (UHP SEC) commercialized as Advanced Polymer Chromatography (APC) by Waters.
</blockquote>
<h5>4. Recycling Gradients in Polymer Chromatography, A New Approach in HPLC on Polymers? (Bastiaan Staal, Ph.D., BASF)</h5>
<blockquote>
Presenter: Bastiaan Staal, Ph.D. (Head of Laboratory, BASF)
</blockquote>
<blockquote>
Dr. Bastiaan Staal is a polymer chemist who finished his Ph.D. in 2005 in the University of Eindhoven (the Netherlands) on copolymer characterization by MALDI-TOF-MS. Since 2006 he is a lab leader at BASF, responsible for GPC and HPLC of polymers for the central research at BASF. His main interests include developing alternative methods in data processing for both HPLC and GPC (mainly handling nonlinear detectors), searching for stable conditions for performing proper GPC, unraveling (MALDI) MS data of co-polymers and hyphenation techniques like GPC-IR, and pushing 2D chromatography (HPLCxGPC) to its limits. His main drive is forming the bridge between theory and the industrial praxis.
</blockquote>
<h3>Afternoon Session - 7:30 - 9:00pm CET</h3>
<h4>LC Method Migration - Will my Validated Method Work on this New LC Sytem?</h4>
Concerned about your validated LC method working on the new instrument? Excited about getting even more out of your method with newer LC systems? This session will introduce a process to identify and mitigate risk due to instrument performance when switching methods to upgraded or new instruments. The session will also address how to scale LC methods.
<h4>Presentations:</h4>
<h5>1. Mitigating Risk While Upgrading LC Assets in the Regulated Laboratory using Quality by Design</h5>
<blockquote>
Presenter: Pauline McGregor, Ph.D. (CChem MRSC, PMcG Consulting)
</blockquote>
<blockquote>
Pauline McGregor Ph.D. CChem MRSC founded PMcG Consulting in September 2006. She has over thirty years’ experience in the Pharmaceutical industry and holds a PhD in organic, analytical chemistry . She originally came to Canada from Edinburgh, Scotland in 1995 to carry out her postdoctoral studies at the University of Western Ontario. Pauline brings a technical expertise to laboratories which enable her to assist them to develop, transfer, verify and validate analytical procedures, and also optimize efficiency with regards to laboratory operations and troubleshooting in an analytical development and QC environment. She been involved in the development and evolution of lifecycle management for analytical procedures and AQbD since 2010. Pauline was a member of the USP expert panel for Validation, Verification and Transfer of Analytical Procedures and a member of a USP Chemical Medicines expert review committee. She continues to be a USP volunteer Expert Advisor and is a Member of the Royal Society of Chemistry , UK. 
</blockquote>
<h5>2. Instrument Suitability Evaluation of HPLC Systems for a USP Organic Impurities (Paula Hong, Ph.D., Waters Corporation)</h5>
<blockquote>
Presenter: Paula Hong, Ph.D. (Principal Consulting Scientist, Waters Corporation)
</blockquote>
<blockquote>
Paula Hong is a Principal Consulting Scientist at Waters Corporation in the Systems Design and Development Application Laboratory. She received her Ph.D. in Inorganic Chemistry from The University of Pennsylvania (Philadelphia, PA), focusing on the reactivity of transition metal/silane complexes. Paula has over 15 years’ experience in the area of LC and LC/MS applications, including amino acid analysis, ion-exchange and peptide mapping. She began her career at Waters in the chemistry division focusing on novel column chemistries for biopharmaceutical applications, including studies on the first hybrid sub 2-µm SEC column. Her more recent work has focused on understanding the role of instrumentation characteristics on chromatographic separations. These studies have included method development for both reversed-phase and supercritical fluid applications as well as method transfer. She has authored over 25 journal articles, white papers, and application notes on a variety of chromatographic principles. 
</blockquote>
<h5>3. Migration of Chromatographic Procedures (Oscar Quattrocchi, D’Amico Sistemas and US Pharmacopeia)</h5>
<blockquote>
Presenter: Oscar Quattrocchi (Training Manager, D’Amico Sistemas and US Pharmacopeia)
</blockquote>
<blockquote>
Oscar Quattrocchi is currently Training Manager at D´Amico Sistemas S.A. since 2008 and a member of the USP General Chapters Expert Committee, Chemical Analysis since 2005, now in the fourth cycle finishing in 2025, former Vicechair of the USP GCEC, former Chair of the USP Residual Solvents Expert Panel, former Vicechair of the USP Medicines Compendium and currently Chair of the USP Spanish Translation Expert Panel. He had worked more than 30 years in the Pharmaceutical Industry as Manager for Analytical Development, Stability Testing and international registration of Drug Substances and Drug Products. He published two books on HPLC and several articles in scientific publications and was a speaker in numerous congresses and symposiums in Argentina, Brazil, and the USA.
</blockquote>
<h5>4. Panel Discussion (Moderated by: Isabelle VuTrieu, Adriana Tirado, Waters Corporation)</h5>
<blockquote>
Moderated by: Adriana Tirado (Market Development Specialist, Mexico &amp; LAD, Waters Corporation)
</blockquote>
<blockquote>
Adriana is the Market Development Specialist in the Spanish-speaking countries of Latin America at Waters and has 15 years of experience in Sales &amp; business development. She joined Waters in 2012 as a sales representative for northern Mexico. She has worked in different companies as a sales executive developing brand presence in the analytical &amp; Life Sciences markets, where she also held the position of service engineer and technical support engineer in liquid chromatography. Prior to that, she was an Associate professor in the Autonomous University of Nuevo León working in the analytical area and supporting the natural products research line of the analytical department in the Faculty of Medicine. She studied Clinical Chemistry Biologist and has a master’s degree in Biomedical Chemistry from the Autonomous University of Nuevo León.
</blockquote>

Waters LC Symposium - Materials and Pharma

More and more companies are choosing to look toward financing options as opposed to capital expenditure to fund their laboratory purchases. We discuss the benefits of this approach.​
<blockquote>
Presenter: Richard Styles (Director of Leasing EMEAI, Waters)
</blockquote>
<blockquote>
Richard has been with Waters for 5 years developing innovative, tailor made finance solutions for our customers. He has over 30 years of domestic and international experience through management roles at bank based and manufacturer captive leasing companies.​
</blockquote>

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