<div>In 2025, two outstanding young female researchers, Drs. Filipa Oliveira and Stella Gonsales, both originally from outside the Czech Republic, received prestigious JUNIOR STAR grants from the Czech Science Foundation (GAČR). JUNIOR STAR enables early career researchers to establish their own independent research groups and significantly advance their scientific careers. Their projects reflect cutting-edge research in materials science and sustainable chemistry, highlighting the international reach and welcoming research environment at UCT Prague.Dr. Stella Gonsales is also a&nbsp;laureate of the Dagmar Procházková Fund, which supports promising scientific projects in sustainable and advanced organic chemistry. Another recipient of this grant is Dr.&nbsp;Anna Valunchene, whose research complements UCT Prague’s&nbsp;sustainability goals. This dual funding underlines Stella’s&nbsp;remarkable achievements and the wide scope of innovative research at UCT Prague.Both Filipa and Stella are actively looking for motivated students and researchers to join their teams, offering a&nbsp;unique opportunity to work at the forefront of science in a&nbsp;vibrant and supportive environment.</div><div><h3>Interview with Filipa Oliveira: Pioneering tubular MXenes for supercapacitor energy storage</h3><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/VSCHT_Praha_V_prestizni_soutezi_GACR_uspely_dve_zahranicni_vedkyne_z_VSCHT_2_da6e538579.jpeg" alt="VŠCHT Prague: JUNIOR STAR Grants at UCT Prague: Two talented women from abroad driving innovation in science: Filipa Oliveira" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_VSCHT_Praha_V_prestizni_soutezi_GACR_uspely_dve_zahranicni_vedkyne_z_VSCHT_2_da6e538579.jpeg 235w," sizes="100vw" width="1500" height="999"><h5>Congratulations on receiving the JUNIOR STAR grant. What does this achievement mean for you and how will it influence your next steps?</h5>Thank you. It’s&nbsp;a huge achievement to receive this prestigious grant. It gives me the opportunity to establish my own research group here at UCT Prague. The JUNIOR STAR program supports talented young scientists in building their teams and accessing resources. This means I&nbsp;now have the support to focus fully on my research about tubular MXenes and their application in supercapacitors.<h5>Why are tubular MXenes so innovative for energy storage?</h5>MXenes are a family of 2D materials with a layered, accordion-like structure and known for their excellent electrical conductivity. Our innovation is to produce them with a tubular morphology, combining the high conductivity and redox activity in superior ion-transport tubular architectures. Their open, hollow structure increases surface area, ion diffusion and charge transport. This could translate to faster, more efficient supercapacitors, critical for sustainable energy technologies.<h5>How did your scientific interest lead you to this field?</h5>Global challenges around green energy made me focus on materials that can improve energy storage. MXenes stood out because changes in the composition and structure can significantly change their properties. I&nbsp;was curious about how tuning different metallic elements in a&nbsp;tubular morphology can impact how MXenes perform and how to optimize them for practical applications.<h5>What challenges have you encountered?</h5>One major challenge is their stability: MXenes oxidize quickly which deteriorates performance. Another challenge is understanding how synthesis conditions of both MXenes and their precursors (MAX phases) must be adapted to create and preserve tubular morphologies since their synthesis mechanisms differ from conventional MXenes. Additionally, effectively communicating the project in the funding proposal to show to reviewers why I&nbsp;should obtain this funding was also a&nbsp;challenge, but thanks to mentorship and collaboration, I&nbsp;overcame these hurdles.<h5>What motivates you most about working at UCT Prague?</h5>The support from colleagues and the excellent technical infrastructure make it a&nbsp;great place to work. Also, being a&nbsp;former member of Professor Sofer’s&nbsp;leading group in 2D&nbsp;materials is inspiring and led me to this achievement.<h5>How do&nbsp;you see your professional development going in the future?</h5>The grant will help me build my own team, acquire equipment, and develop collaborations. My long-term vision is to contribute significantly to sustainable energy solutions and scientific progress both locally and internationally.<h5>You are looking for new team members. What kind of students or scientists do&nbsp;you need?</h5>We are currently welcoming enthusiastic master's&nbsp;students, PhD candidates, and postdocs who are passionate about materials science and eager to explore new frontiers in MXenes and energy storage. If you love curiosity-driven research and want to be part of a&nbsp;growing international team, we encourage you to join us.<h3>Interview with Stella Gonsales: Catalysis as a&nbsp;key to polymer recycling</h3><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/VSCHT_Praha_V_prestizni_soutezi_GACR_uspely_dve_zahranicni_vedkyne_z_VSCHT_3_3d0ded6274.jpeg" alt="VŠCHT Prague: JUNIOR STAR Grants at UCT Prague: Two talented women from abroad driving innovation in science: Stella Gonsales" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_VSCHT_Praha_V_prestizni_soutezi_GACR_uspely_dve_zahranicni_vedkyne_z_VSCHT_3_3d0ded6274.jpeg 233w," sizes="100vw" width="1499" height="1000"><h5>Congratulations on your JUNIOR STAR grant and also being awarded the Dagmar Procházková Fund. What does receiving both mean to you and how will they shape your work?</h5>Thank you. Both grants are hugely important. The JUNIOR STAR grant allows me to expand my group and resources for research into catalytic recycling of polymers, while the Dagmar Procházková Fund supports complementary projects such as synthesizing new biodegradable polymers. Together, they help tackle the plastic waste problem from multiple scientific angles.<h5>Could you explain your research in layperson’s&nbsp;terms?</h5>Most plastics have strong carbon-carbon bonds. We insert more cleavable double bonds into polymers that can be broken down by catalytic reactions called olefin metathesis, making recycling on a&nbsp;molecular level more feasible.<h5>What makes the JUNIOR STAR grant particularly important for your research and career development?</h5>The JUNIOR STAR grant is a&nbsp;prestigious and highly competitive funding opportunity aimed at excellent early-career scientists within eight years of completing a&nbsp;Ph.D. It provides up to 25&nbsp;million CZK over five years, allowing recipients to establish independent research groups and pursue innovative scientific topics. This grant is crucial for building a&nbsp;solid foundation, acquiring necessary equipment, and recruiting talented team members, enabling the pursuit of ambitious projects that can significantly contribute to both the Czech scientific community and global challenges.<h5>What collaborations support your research?</h5>The collaboration between UCT Prague and the Institute of Organic Chemistry and Biochemistry (IOCB) of the Czech Academy of Sciences primarily provides financial and technical support. The cooperation helps with funding, access to advanced equipment, and operational resources needed for running research projects.<h5>What advice would you give young scientists aiming to succeed?</h5>I&nbsp;encourage thinking outside the box and combining diverse knowledge you acquire during your career to address complex problems that are exciting and relevant to you.<h5>Your laboratory bears the name of Otto Wichterle and was ceremonially opened in the presence of Professor Kamil Wichterle. How does Wichterle’s&nbsp;legacy inspire you personally?</h5>Wichterle’<s>’</s>s&nbsp;innovative spirit motivates me to push creative boundaries and pursue novel solutions in sustainable chemistry.<h5>What are your visions for the future?</h5>I&nbsp;aim to build a&nbsp;research group that advances sustainable polymer recycling, contributing to environmental responsibility and the circular economy.<h5>You are recruiting people for your team. What skills do&nbsp;they need to have?</h5>We are looking for talented Ph.D. students and postdocs experienced in air-sensitive catalysis techniques. If you want to contribute to transformative research in sustainable chemistry and join a&nbsp;dynamic team, this is a&nbsp;great opportunity.</div>

JUNIOR STAR Grants at UCT Prague: Two talented women from abroad driving innovation in science

The clean laboratories of the CEITEC Nano research infrastructure at CEITEC Brno University of Technology house a four-meter-tall TITAN transmission electron microscope for researching materials at the atomic level. This scientific device underwent two significant upgrades this year, entailing the addition of two state-of-the-art technologies: an electromagnetic lens aberration corrector for scanning transmission electron microscopy and an electron energy loss spectrometer equipped with cameras featuring today's most sensitive sensors. Thanks to these upgrades, TITAN has become a state-of-the-art device that can only be found in a few of the world's most advanced laboratories in this configuration.The TITAN Themis microscope was manufactured in 2015 by FEI (now Thermo Fisher Scientific) and has been in use at CEITEC BUT since 2016. At the time of its acquisition, it was one of the most powerful commercially available electron microscopes; however, it lacked a corrector for optical defects in the lenses that form the narrow electron beam scanning the sample. This meant limited resolution and a lower ability to analyze the chemical composition and physical properties of materials at the atomic level."The latest generation S-CORR aberration corrector allows the electron beam to be focused to a size up to twice smaller than an atom, while also providing a higher electron current. This has led to a significant increase in the resolution and analytical capabilities of the microscope," explains Jan Michalička, guarantor of the TITAN microscope. "Thanks to the new corrector, our microscope achieves the world's highest standard in resolution, specifically less than 50 picometers at an acceleration voltage of 300 keV." For better understanding, he adds a comparison: "Imagine the ratio of the size of a golf ball to that of planet Earth. That is exactly the ratio of an atom measuring 100 pm to a golf ball." Thanks to this resolution, scientists are not only able to image individual atoms, but also to determine their chemical nature through further analysis. This is of fundamental importance, for example, for the development of new catalysts for a more environmentally friendly chemical industry.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/CEITEC_Upgrade_transmisniho_elektronoveho_mikroskopu_TITAN_zaradil_CEITEC_mezi_elitni_laboratore_8ebd8d7245.jpg" alt="CEITEC/CEITEC BUT archive: Upgrade of TITAN transmission electron microscope ranks CEITEC among elite laboratories: Differences in resolution before and after the installation of the aberration corrector." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_CEITEC_Upgrade_transmisniho_elektronoveho_mikroskopu_TITAN_zaradil_CEITEC_mezi_elitni_laboratore_8ebd8d7245.jpg 245w," sizes="100vw" width="1600" height="904">The new corrector also allows the microscope to achieve high resolution even with low-energy electrons. This is crucial for studying highly sensitive materials such as graphene and other two-dimensional structures, which would be damaged by a stronger electron beam. "Electrons interact strongly with the sample and can damage it at the atomic level, for example, by changing its structure and chemical composition. With the new corrector, we can achieve atomic resolution even at the lowest acceleration voltage of 60 keV, allowing us to study even very sensitive materials in a virtually unchanged state," says Jan Michalička.<h4>The additional installation of a corrector at the CEITEC laboratory is unique worldwide</h4>Correctors of optical defects in electromagnetic lenses are an exceptional technology that has completely changed the world of electron microscopy. For a long time, they were considered technically impossible, and the absence of correctors essentially prevented research into the structure and properties of materials at the atomic level. It was not until the 1990s that a group of four scientists – Harald Rose, Max Haider, Knut Urban, and Ondřej Křivánek – succeeded in implementing this technology, for which they received the prestigious Kavli Prize in 2020. “Correctors basically consist of a pair of complex lenses, each containing a series of magnetic multipoles. In the case of the correctors invented by the first three scientists mentioned above, defects are removed by two hexapole lenses. Our new corrector is based on the same concept,” adds Jan Michalička.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/CEITEC_Upgrade_transmisniho_elektronoveho_mikroskopu_TITAN_zaradil_CEITEC_mezi_elitni_laboratore_2_c7e74d8554.jpeg" alt="CEITEC/CEITEC BUT archive: Upgrade of TITAN transmission electron microscope ranks CEITEC among elite laboratories: Delivered aberration corrector prior to installation, with the TITAN microscope in the background." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_CEITEC_Upgrade_transmisniho_elektronoveho_mikroskopu_TITAN_zaradil_CEITEC_mezi_elitni_laboratore_2_c7e74d8554.jpeg 117w," sizes="100vw" width="1600" height="2133">The additional installation of a corrector is unique in itself nowadays. Similarly complex technologies are usually installed during the manufacture of microscopes in the factory, in this case in the Netherlands. However, in Brno, the microscope was successfully upgraded with a corrector under the limited conditions of the laboratory. The installation of the corrector took about four months and required the dismantling of a large part of the microscope. "With this installation, we basically went back to the time when the four scientists mentioned above placed their prototype corrector on an older microscope, thus improving its performance," says Jan Michalička with a smile, adding that the most difficult part was the precise adjustment of the corrector and the entire optics of the microscope in order to achieve top parameters. "Even though most things are now controlled by computers, there are only a few people in the world who can install and tune a corrector to the highest level of accuracy. We are therefore extremely pleased to have had such experts at our disposal here."<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/CEITEC_Upgrade_transmisniho_elektronoveho_mikroskopu_TITAN_zaradil_CEITEC_mezi_elitni_laboratore_4_b2cf95fb5c.jpeg" alt="CEITEC/CEITEC BUT archive: Upgrade of TITAN transmission electron microscope ranks CEITEC among elite laboratories: Installation of the aberration corrector – removal of the condenser." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_CEITEC_Upgrade_transmisniho_elektronoveho_mikroskopu_TITAN_zaradil_CEITEC_mezi_elitni_laboratore_4_b2cf95fb5c.jpeg 117w," sizes="100vw" width="1600" height="2133"><h4>New spectrometer will enable scientists to see more</h4>The second and equally important upgrade to the TITAN microscope is the installation of the latest generation GIF Continuum HR electron energy loss spectrometer by Gatan. This is an approximately two-meter-long device installed horizontally under the microscope, whose main component is a magnetic prism that separates the electron beam according to their energy losses. The spectra of these losses provide enormous information about the sample, principally at the atomic level, as they are characteristic of the given state of the atoms, such as the valence arrangement of their electron shell. In combination with the new corrector, the spectra can be used to analyze the chemical bonds, arrangement in the crystal lattice, or the entire range of physical properties of atomic nanostructures down to the level of individual atoms.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/CEITEC_Upgrade_transmisniho_elektronoveho_mikroskopu_TITAN_zaradil_CEITEC_mezi_elitni_laboratore_8_fdab871ef5.jpeg" alt="CEITEC/CEITEC BUT archive: Upgrade of TITAN transmission electron microscope ranks CEITEC among elite laboratories: Installation of the spectrometer beneath the microscope, magnetic prism." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_CEITEC_Upgrade_transmisniho_elektronoveho_mikroskopu_TITAN_zaradil_CEITEC_mezi_elitni_laboratore_8_fdab871ef5.jpeg 117w," sizes="100vw" width="1600" height="2133">An essential part of the spectrometer are the state-of-the-art K3 and Stela cameras, which can directly detect and count individual electrons. At the same time, these cameras are extremely fast and their sensors capture data without noise. "These features of our cameras are key to measuring sensitive or dynamically changing samples and allow us to obtain information that was previously invisible to electron microscopes," says Jan Michalička.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/CEITEC_Upgrade_transmisniho_elektronoveho_mikroskopu_TITAN_zaradil_CEITEC_mezi_elitni_laboratore_9_d8b87903f2.jpeg" alt="CEITEC/CEITEC BUT archive: Upgrade of TITAN transmission electron microscope ranks CEITEC among elite laboratories: Installed high-performance spectrometer cameras." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_CEITEC_Upgrade_transmisniho_elektronoveho_mikroskopu_TITAN_zaradil_CEITEC_mezi_elitni_laboratore_9_d8b87903f2.jpeg 117w," sizes="100vw" width="1600" height="2133">Last but not least, the spectrometer will open up completely new possibilities for measuring the magnetic properties of atomic structures. The new spectrometer will also be used for such experiments within the project TERAFIT, which financed this upgrade, and which focuses on research into materials for ultra-high capacity, speed, and energy efficiency in information technology. "The device is fully prepared for advanced experiments and the use of modern software tools, including artificial intelligence," adds Vojtěch Uhlíř, head of the Nanomagnetism and Spintronics research group at CEITEC BUT and one of the TERAFIT project investigators, highlighting the advantages of the spectrometer.Together with the corrector, the spectrometer represents a breakthrough in the analysis of material properties, and according to Jan Michalička, CEITEC now has one of the most powerful microscopes available. “In modern materials science, for example, in the development of magnetic memories, quantum materials, or 2D structures, it is necessary to see not only atoms, but also their behaviour in real time, including magnetic states. And it is this spectrometer that pushes the boundaries of what we can see and analyze.” Michal Urbánek, head of the CEITEC Nano laboratories and coordinator of the large research infrastructure <a target="_blank" rel="noopener noreferrer" href="https://www.czechnanolab.cz/">CzechNanoLab</a>, agrees with him, adding that the device can now contribute to scientific knowledge on a global scale. “Thanks to its integration into the large CzechNanoLab research infrastructure, this state-of-the-art microscope is accessible not only to scientists from CEITEC, but also to other institutions in the Czech Republic and abroad.”<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/CEITEC_Upgrade_transmisniho_elektronoveho_mikroskopu_TITAN_zaradil_CEITEC_mezi_elitni_laboratore_10_7a2b57cc6d.jpeg" alt="CEITEC/CEITEC BUT archive: Upgrade of TITAN transmission electron microscope ranks CEITEC among elite laboratories: Final configuration of the TITAN microscope after installation of the aberration corrector and spectrometer." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_CEITEC_Upgrade_transmisniho_elektronoveho_mikroskopu_TITAN_zaradil_CEITEC_mezi_elitni_laboratore_10_7a2b57cc6d.jpeg 117w," sizes="100vw" width="1600" height="2133"><blockquote>Do you want to know more? Read the <a target="_blank" rel="noopener noreferrer" href="https://www.ceitec.eu/upgrade-of-titan-transmission-electron-microscope-ranks-ceitec-among-elite-laboratories-expert-version/t11696?secret=40ab0267-ec7e-11f0-8f5d-2ed9ab825d4b">expert version</a> of this article.</blockquote>

Upgrade of TITAN transmission electron microscope ranks CEITEC among elite laboratories

Scientists at IOCB Prague are uncovering new details of gene transcription. They have identified a previously unknown molecular mechanism by which the transcription of genetic information from deoxyribonucleic acid (DNA) into ribonucleic acid (RNA) can be initiated. The researchers focused on a specific class of molecules known as alarmones, which are found in cells across a wide range of organisms and whose levels often increase under conditions of cellular stress. The results were published in the prestigious scientific journal Nature Chemical Biology.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/UOCHB_Vyzkum_z_UOCHB_odhaluje_dosud_nepoznany_zpusob_prepisu_geneticke_informace_bc2bfffa6c.jpg" alt="IOCB Prague/Tomáš Belloň: Research from IOCB Prague reveals a previously unknown mechanism of genetic transcription: Dr. Hana Cahová, head of the Chemical Biology of Nucleic Acids research group." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_UOCHB_Vyzkum_z_UOCHB_odhaluje_dosud_nepoznany_zpusob_prepisu_geneticke_informace_bc2bfffa6c.jpg 234w," sizes="100vw" width="2000" height="1335"><div>Molecules of ribonucleic acid can carry a variety of chemical modifications at one end, known as caps. In eukaryotic organisms, including human cells, the best-known cap plays an important role in RNA stability and in regulating its subsequent fate. In recent years, however, it has become clear that alternative, non-canonical RNA caps also exist, although their formation and the mechanisms by which they are attached to RNA remain only partially understood. These include alarmone caps, formed by dinucleoside polyphosphate molecules, that protect cellular RNA at moments when the cell is under threat.In their study, <a target="_blank" rel="noopener noreferrer" href="https://cahova.group.uochb.cz/en">Dr. Hana Cahová</a> and colleagues examined bacterial RNA polymerase and investigated how this enzyme can initiate transcription using dinucleoside polyphosphates (NpNs) instead of the standard RNA building blocks. For the first time, the scientists described, at the atomic level, how RNA bearing an alarmone cap can be generated directly at the initiation of gene transcription. They also observed that NpNs bind through a different type of base pairing than is typically observed.The work was significantly shaped by Valentina Serianni from Hana Cahová’s team, who demonstrated the ability of dinucleoside polyphosphates to initiate gene transcription, and by Jana Škerlová, who focused on the structural analysis of RNA polymerase. Using cryogenic electron microscopy data, she showed how dinucleoside polyphosphate molecules bind within the active site of RNA polymerase – that is, the core of the enzyme where genetic information is transcribed. Together, their findings help to elucidate the processes that accompany the transcription of genetic information from DNA to RNA.Hana Cahová adds: “We’re describing something that truly occurs in cells and that we’re now able to observe directly at the level of individual molecules. This allows us to answer fundamental questions about cellular processes, such as how cells adapt to stress. RNA plays a central role in this, as it carries the cascade of information underlying any cellular response – for example, to threatening conditions caused by nutrient deprivation or temperature shock.”<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/UOCHB_Vyzkum_z_UOCHB_odhaluje_dosud_nepoznany_zpusob_prepisu_geneticke_informace_2_0fe88ff9e9.jpg" alt="IOCB Prague/Tomáš Belloň: Research from IOCB Prague reveals a previously unknown mechanism of genetic transcription: Dr. Tomáš Kouba, head of the Cryogenic Electron Microscopy core facility." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_UOCHB_Vyzkum_z_UOCHB_odhaluje_dosud_nepoznany_zpusob_prepisu_geneticke_informace_2_0fe88ff9e9.jpg 234w," sizes="100vw" width="2000" height="1335"><div>Cryogenic electron microscopy (cryo-EM) was central to the project. This part of the work was led by Dr. Tomáš Kouba, one of the authors of the study. “Cryogenic electron microscopy allows us to freeze biological molecules in a state very close to their natural form and then determine their three-dimensional structure. This makes it possible to look directly into the active centers of enzymes and observe their function down to the atomic level,” he explains.Last year, IOCB Prague opened a new <a target="_blank" rel="noopener noreferrer" href="https://cryoem.group.uochb.cz/en">cryo-EM center</a> that is unique within the Czech research environment. State-of-the-art cryogenic electron microscopes are housed in a specially designed building and enable the study of biological processes with exceptional structural precision.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/UOCHB_Vyzkum_z_UOCHB_odhaluje_dosud_nepoznany_zpusob_prepisu_geneticke_informace_3_4d881e7a58.jpg" alt="IOCB Prague: Research from IOCB Prague reveals a previously unknown mechanism of genetic transcription: This work shows how NpnNs initiate bacterial transcription. Cryo-EM reveals how nucleobases pair with the template: one in canonical and one in reverse Watson–Crick mode, providing a structural basis for their function as non-canonical RNA caps." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_UOCHB_Vyzkum_z_UOCHB_odhaluje_dosud_nepoznany_zpusob_prepisu_geneticke_informace_3_4d881e7a58.jpg 245w," sizes="100vw" width="2000" height="1077"><blockquote><h4>The Original article</h4><h4><a target="_blank" rel="noopener noreferrer" href="https://www.nature.com/articles/s41589-025-02134-5">Molecular insight into 5′ RNA capping with NpnNs by bacterial RNA polymerase</a></h4>Valentina M. Serianni, Jana Škerlová, Anna Knopp Dubánková, Anton Škríba, Hana Šváchová, Tereza Vučková, Anatolij Filimoněnko, Milan Fábry, Pavlína Řezáčová, Tomáš Kouba &amp; Hana Cahova&nbsp;Nat. Chem. Biol. 21 (2026)<a target="_blank" rel="noopener noreferrer" href="https://doi.org/10.1038/s41589-025-02134-5">https://doi.org/10.1038/s41589-025-02134-5</a><h6>licensed under <a target="_blank" rel="noopener noreferrer" href="https://creativecommons.org/licenses/by/4.0/">CC-BY 4.0</a></h6></blockquote><h4>Abstract</h4>RNA capped with dinucleoside polyphosphates has been discovered in bacteria and eukaryotes only recently. The likely mechanism of this specific capping involves direct incorporation of dinucleoside polyphosphates by RNA polymerase as noncanonical initiating nucleotides. However, how these compounds bind into the active site of RNA polymerase during transcription initiation is unknown. Here, we explored transcription initiation in vitro, using a series of DNA templates in combination with dinucleoside polyphosphates and model RNA polymerase from Thermus thermophilus. We observed that the transcription start site can vary on the basis of the compatibility of the specific template and dinucleoside polyphosphate. Cryo-electron microscopy structures of transcription initiation complexes with dinucleoside polyphosphates revealed that both nucleobase moieties can pair with the DNA template. The first encoded nucleotide pairs in a canonical Watson–Crick manner, whereas the second nucleobase pairs noncanonically in a reverse Watson–Crick manner. Our work provides a structural explanation of how dinucleoside polyphosphates initiate RNA transcription.</div></div>

Research from IOCB Prague reveals a previously unknown mechanism of genetic transcription

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Since its establishment in 2011, CEITEC has quickly developed into a cutting-edge infrastructure for research which performs highly alongside the best institutes in Europe. Among the main priorities of CEITEC are the promotion of a motivating and dynamic international scientific environment, the provision of state-of-the-art research infrastructure, and the policy of open communication and equal opportunities.

CEITEC

The University of Chemistry and Technology, Prague is a natural centre of first-rate study and research in the area of chemistry in Czechia and is one of the country's largest educational and research institutions focused on technical chemistry, chemical and biochemical technologies, material and chemical engineering, food chemistry, and environmental studies.

UCT Prague

The Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences (IOCB Prague) is a leading scientific institution in the Czech Republic, recognized internationally. Its primary mission is basic research in the fields of chemical biology and medicinal chemistry, organic and material oriented chemistry, chemistry of natural compounds, biochemistry and molecular biology, physical chemistry, theoretical chemistry, and analytical chemistry. 

Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences

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<div><div><div>Industries from mining and exploration to scrap metal recycling depend on fast, accurate elemental analysis. The Thermo Scientific™ Niton™ XL3t GOLDD+ XRF Analyzer provides reliable, real-time data for sample identification and positive material identification for even difficult-to-analyze light elements, without helium purging or vacuum pumps.&nbsp;The Niton XL3t GOLDD+ Analyzer delivers a feature-rich package enhanced with Geometrically Optimized Large Area Drift Detector (GOLDD™) technology for improved light element (Mg-S) analysis, the lowest limits of detection and fastest measurement times.</div><div><h3>⚡ Performance:</h3>GOLDD Technology:&nbsp;When low detection limits and high sample throughput are critical, the Niton XL3t GOLDD+ XRF analyzer delivers measurement times up to 10-times faster than conventional Si-PIN detectors and up to 3-times more precise than conventional smaller silicon drift detectors (SDD) - without helium purge or vacuum. For further enhancing light element analysis, a helium purge option is available. Niton analyzers also feature the highest performance X-ray tube and speed detector available on the market.<h3>🧪 Wide Range of Applications:</h3><ul><li>Scrap Metal Recycling:&nbsp;<ul><li>Sorts aluminum, titanium and bronze alloys, and achieves superior performance for tramp and trace element analysis.</li></ul></li><li>Mining Exploration:&nbsp;<ul><li>Fast, accurate analysis of light elements.&nbsp;</li><li>Identifies anomalies near the averages naturally found in the earth's crust.&nbsp;</li><li>Facilitates advanced exploration and soil analysis, concentrate measurement, ore blending, precious metal identification and lab analysis prequalification.</li></ul></li><li>Environmental:&nbsp;<ul><li>Detects contaminants such as chlorine and sulfur in sediment and arsenic in soil.&nbsp;</li><li>Identifies environmental hazards in residential, commercial and industrial settings, such as toxic drywall.</li></ul></li></ul></div></div><h3>⚙️ Features</h3><ul><li>Standard analytical range: Up to 30 elements from Mg to U (varies by application).</li><li>Most powerful x-ray tube on the market for handheld XRF analysis.</li><li>Point and shoot simplicity- very easy to use even by nontechnical personnel.</li><li>Rugged design for real-world industrial environments.</li><li>Nondestructive analysis with near instantaneous results.</li><li>Sealed against moisture and dust.</li><li>Ergonomically designed.</li><li>Daylight-readable icons.</li><li>Incorporates multi-language options.</li><li>Color, touch-screen display.</li></ul></div><div><h3>🔗 Connectivity</h3><ul><li>Integrated USB and Bluetooth™ communications provide direct data transfer to your PC or networked storage device. &nbsp;</li><li>Standard Thermo Scientific™ Niton Data Transfer (NDT™) PC software allows you to: &nbsp;<ul><li>Set operator permissions &nbsp;</li><li>Generate custom reports &nbsp;</li><li>Print certificates of analysis &nbsp;</li><li>Remotely monitor and control the instrument from your PC &nbsp;</li></ul></li><li>Optional accessories: Bluetooth barcode reader, Bluetooth printer, Bluetooth GPS</li></ul><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Niton_XL_3t_GOLDD_XRF_Analyzer_5_9e51a6a9ac.jpg" alt="Thermo Scientific™ Niton™ XL3t GOLDD+ XRF Analyzer" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Niton_XL_3t_GOLDD_XRF_Analyzer_5_9e51a6a9ac.jpg 219w," sizes="100vw" width="650" height="464"><h3>📏 Specifications</h3><ul><li>Analytical Range: Up to 30 elements from Mg to U (varies by application)</li><li>Available Analytical Modes: Varies by application<ul><li>Alloy Modes: Metal Alloy, Electronics Alloy, Precious Metals</li><li>Bulk Modes: Soil, Mining, TestAll</li><li>Plastic Modes: RoHS Plastics, Toy and Consumer Goods, Plastics, TestAll, Painted Products</li><li>Custom Modes: Upon request</li></ul></li><li>Certifications/Compliance: CE, RoHS</li><li>Data Entry: Touch-screen keyboard, user-programmable pick lists, optional wireless remote barcode reader</li><li>Data Memory: 32MB internal system memory / 128 MB internal user storage</li><li>Data Storage: Internal &gt;10,000 readings with spectra</li><li>Data Transfer: USB, Bluetooth and RS-232 serial communication</li><li>Description: Niton XL3t GOLDD+ XRF Analyzer</li><li>Dimensions (L × W × H): 9.6 × 9.05 × 3.75 in. (244 × 230 × 95.5 mm)</li><li>Display Type: Tilting, color, touch-screen display</li><li>Height (English): 3.75 in.</li><li>Height (Metric): 95.5 mm</li><li>Item Description: XL3t GOLDD+ XRF Analyzer</li><li>Length (English): 9.6 in.</li><li>Length (Metric): 244 mm</li><li>Licensing: Varies by region. Contact your local distributor.</li><li>Max. Power: 2W</li><li>Operating System: Ownership</li><li>Optional Accessories:<ul><li>3mm small-spot collimation</li><li>Portable test stand</li><li>Stationary (benchtop) test stand</li><li>Mobile test stand</li><li>Field Mate</li><li>Thermo Scientific™ Extend-a-Pole™</li><li>Welding mask</li><li>Thermo Scientific™ HotFoot™ hot surface adapter</li><li>Soil testing guard</li></ul></li><li>Power Consumption: 0 to 200 μA</li><li>Security Features: Password-protected user security</li><li>Standard Accessories:<ul><li>Integrated CCD camera for locating and storing images</li><li>Locking shielded carrying case</li><li>Shielded belt holster</li><li>Two lithium-ion battery packs</li><li>Spare battery pack</li><li>110/220 VAC battery charger/AC adaptor</li><li>PC connection cables (USB and RS-232)</li><li>Thermo Scientific™ Niton Data Transfer (NDT™) PC software</li><li>Safety lanyard</li><li>Check samples/standards</li></ul></li><li>System Electronics: 533 MHz ARM 11 CPU, 300 MHz dedicated DSP, 80 MHz ASICS DSP for signal processing</li><li>Tube Type: Ag anode 50 kV and 200 μA</li><li>Voltage: 6 to 50 kV</li><li>Weight (English): 3 lb.</li><li>Weight (Metric): 1.3 kg</li><li>Width (English): 9.05 in.</li><li>Width (Metric): 230 mm</li><li>Applications: Sample Identification, Positive Material Identification</li><li>Detector Type: Geometrically Optimized Large Area Drift Detector</li><li>Tube Voltage: 6 to 50 kV</li><li>Unit Size: Each</li></ul><h3>Which analyzer for your application?</h3><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Niton_XRF_Analyzer_e7e7a24b10.jpg" alt="Thermo Scientific™ Niton™ handheld XRF Analyzers - Niton handheld XRF analyzers are built for rugged use and deliver rapid, lab-quality results" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Niton_XRF_Analyzer_e7e7a24b10.jpg 145w," sizes="100vw" width="1024" height="1102"></div>

Thermo Scientific Niton XL2 100G General Metal Analyzer

Get immediate, nondestructive elemental analysis of alloy materials from titanium to nickel with the Thermo Scientific™ Niton™ XL2 100G General Metal Analyzer. 

<div><div><div><div><div>Get immediate, nondestructive elemental analysis of alloy materials from titanium to nickel with the Thermo Scientific™ Niton™ XL2 100G General Metal Analyzer. The XL2 100G analyzer is a practical, cost-effective solution that offers fast analysis for general alloy identification, basic fabrication, and scrap metal sorting.&nbsp;This high value, high performance analyzer features advanced electronics yet it is ruggedly built to withstand the harshest environments, in the field or on the shop floor.</div><div><h3>The value choice to ensure accuracy, precision, and ease of use:</h3><ul><li>Precise elemental analysis of alloy materials</li><li>Very easy to use – even by non-technical personnel</li><li>Ruggedly designed for the most challenging industrial environments, and sealed against moisture and dust</li><li>Completely nondestructive test</li><li>Ergonomically designed&nbsp;</li><li>Customizable menus with multiple language options and daylight-readable icons</li><li>Standard analytical range of more than 25 elements from sulfur to uranium.</li></ul></div></div><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Niton_XL_2_100_G_General_Metal_Analyzer_340e83faa3.jpg" alt="Thermo Scientific™ Niton™ XL2 100G General Metal Analyzer" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Niton_XL_2_100_G_General_Metal_Analyzer_340e83faa3.jpg 156w," sizes="100vw" width="650" height="650"><h3>Specifications</h3><ul><li>Analytical Range: 25 elements from Ti to Bi</li><li>Available Analytical Modes: Alloy Modes: Metal Alloy</li><li>Certifications/Compliance: CE, RoHS</li><li>Data Entry:&nbsp;<ul><li>Touch-screen keyboard</li><li>User-programmable pick lists</li><li>Optional wireless remote barcode reader</li></ul></li><li>Data Storage: Internal &gt;10,000 readings with spectra</li><li>Data Transfer: USB, Bluetooth™, and RS-232 serial communication</li><li>Dimensions (L x W x H): 10.25 × 11 × 4 in. (256 × 275 × 100 mm)</li><li>Display Type: Fixed angle, color, touch-screen display</li><li>IP Rating: IP54 (splash and dust proof)</li><li>Licensing: Varies by region. Contact your local distributor.</li><li>Max. Power: 2W</li><li>Operating System: Ownership</li><li>Optional Accessories:&nbsp;<ul><li>Thermo Scientific™ portable test stand</li><li>Stationary (bench-top) stand</li><li>Mobile test stand</li></ul></li><li>Security Features: Password-protected user security</li><li>Standard Accessories:&nbsp;<ul><li>Locking shielded carrying case</li><li>Shielded belt holster</li><li>One 6-cell Li-ion battery pack</li><li>110/220 VAC battery charger/AC adaptor</li><li>PC connection cables (USB and RS-232)</li><li>Niton Data Transfer (NDT) PC software</li><li>Safety lanyard</li><li>Check samples/standards</li></ul></li><li>System Electronics:&nbsp;<ul><li>400 MHz ARM 11 CPU</li><li>300 MHz dedicated DSP</li><li>80 MHz ASICS DSP for signal processing</li><li>4096 channel MCA</li><li>64 MB internal system memory / 128 MB internal user storage</li></ul></li><li>Tube Type: Ag anode 38kV maximum, 80 μA maximum</li><li>Weight (English): 3 lbs 5.8 oz</li><li>Weight (Metric): 1.53 kg</li><li>Applications: Elemental Analysis</li><li>Detector Type: High-performance Semiconductor</li><li>Tube Voltage: 38 kV</li><li>Unit Size: Each</li></ul><h3>Which analyzer for your application?</h3><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Niton_XRF_Analyzer_e7e7a24b10.jpg" alt="Thermo Scientific™ Niton™ handheld XRF Analyzers - Niton handheld XRF analyzers are built for rugged use and deliver rapid, lab-quality results" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Niton_XRF_Analyzer_e7e7a24b10.jpg 145w," sizes="100vw" width="1024" height="1102"></div></div></div>

Thermo Scientific Niton XL2 XRF Precious Metal Analyzer

The Thermo Scientific™ Niton™ XL2 XRF Precious Metal Analyzer provides a fast, accurate, and most importantly, nondestructive method to test the purity and chemistry of all precious metals. 

<div><div><div><div><div>With the volatility and high price of gold, failing to detect just a small variation in composition can be an expensive mistake. The Thermo Scientific™ Niton™ XL2 XRF Precious Metal Analyzer provides a fast, accurate, and most importantly, nondestructive method to test the purity and chemistry of all precious metals.&nbsp;The Niton XL2 XRF Precious Metal Analyzer quickly detects gold plating and counterfeit gold and gives you the exact elemental composition of jewelry and coins so you can be absolutely certain of the value of the precious metals you buy and sell.</div><div>The Niton XL2 XRF Precious Metal Analyzer delivers accurate analysis in just seconds in an easy-to-use, robust and reliable package. Measure the content of all gold and precious metals with no need to manually change your calibration based on the metal you're analyzing—e.g., gold (Au), silver (Ag), platinum (Pt), palladium (Pd).<ul><li>Easier, faster and more accurate than nitric acid test methods.</li><li>Faster, more comprehensive analysis than fire assay with comparable accuracy.</li><li>Efficiently identify most gold-plated items with Thermo Scientific AuDIT™ gold-plating detection technology.</li><li>Precisely determine the presence and concentration of other trace alloying elements and dangerous heavy elements, which could impact valuation and future refining needs.</li></ul><h3>⚙️ Features</h3><ul><li>Standard analytical range: 22 elements from S to U (varies by application).</li><li>Point and shoot simplicity—very easy to use even by nontechnical personnel.</li><li>Ideally suited for retail environments.</li><li>Nondestructive analysis with near-instantaneous results.</li><li>Ergonomic design.</li></ul></div></div><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Niton_XL_2_XRF_Precious_Metal_Analyzer_6d4f6473b2.jpg" alt="Thermo Scientific™ Niton™ XL2 XRF Precious Metal Analyzer" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Niton_XL_2_XRF_Precious_Metal_Analyzer_6d4f6473b2.jpg 144w," sizes="100vw" width="650" height="706"><h3>📏 Specifications</h3><ul><li>Applications: Non-destructive method to test the purity and chemistry of precious metals</li><li>Available Analytical Modes: Varies by application<ul><li>Alloy modes: metal alloy, electronics alloy, precious metals.&nbsp;</li><li>Bulk modes: mining, soil.&nbsp;</li><li>Plastic modes: RoHS plastics, toy and consumer goods plastics, Thermo Scientific TestAll, painted products.&nbsp;</li><li>Custom modes: upon request</li></ul></li><li>Data Memory: 64MB internal system memory / 128MB internal user storage</li><li>Data Storage: Internal &gt;10,000 readings with spectra</li><li>Data Transfer: USB, Bluetooth and RS-232 serial communication</li><li>Description: Niton XL2 XRF Precious Metal Analyzer</li><li>Detector Type: High-performance Semiconductor</li><li>Display Type: Fixed angle, color, touch-screen display</li><li>Height (English): 4 in.</li><li>Height (Metric): 100 mm</li><li>Length (English): 10.25 in.</li><li>Length (Metric): 256 mm</li><li>Width (English): 11 in.</li><li>Width (Metric): 275 mm</li><li>Optional Accessories:&nbsp;<ul><li>Portable test stand</li><li>Stationary (bench-top) stand</li><li>Mobile test stand</li><li>Welding mask</li><li>Soil testing guard</li></ul></li><li>Power Consumption: 100μA</li><li>Security Features: Password-protected user security</li><li>Standard Accessories:&nbsp;<ul><li>Locking shielded carrying case</li><li>Shielded belt holster</li><li>Two 6-cell lithium-ion battery packs</li><li>110/220VAC battery charger/AC adaptor</li><li>PC connection cables (USB and RS-232)</li><li>Thermo Scientific™ Niton Data Transfer (NDT™) PC software</li><li>Safety lanyard</li><li>Check samples/standards</li></ul></li><li>System Details:&nbsp;<ul><li>4096 channel MCA</li><li>64MB internal system memory / 128MB internal user storage</li></ul></li><li>Tube Type: Ag anode 45 kV maximum, 80μA maximum</li><li>Tube Voltage: 45 kV</li><li>Weight (English): 3.0 lb., 5.8 oz.</li><li>Weight (Metric): 1.53 kg</li><li>System Electronics:&nbsp;<ul><li>400 MHz ARM 11 CPU</li><li>300 MHz dedicated DSP</li><li>80 MHz ASICS DSP for signal processing</li></ul></li><li>Data Entry: Touch-screen keyboard, user-programmable pick lists, optional wireless remote barcode reader</li><li>Licensing: Registration: Varies by region. Contact your local distributor.</li><li>Dimensions (L × W × H): 10.25 × 11 × 4 in. (256 × 275 × 100 mm)</li><li>Operating System: Ownership</li><li>Certifications/Compliance: CE, RoHS</li><li>IP Rating: IP54 (splash and dust proof)</li><li>Max. Power: 2W</li><li>Unit Size: Each</li></ul></div></div></div>

Thermo Scientific Niton Apollo Handheld LIBS Analyzer

High-performance handheld LIBS analyzer for fast, reliable carbon analysis. Ideal for L/H grade steels and alloy verification with maximum mobility and on-site productivity.

Confidently perform elemental analysis with the Thermo Scientific™ Niton™ Apollo™ handheld LIBS analyzer. When carbon detection and mobility are top of mind, industrial businesses rely on the Niton Apollo analyzer for excellent performance and enhanced productivity.&nbsp;Identify low alloy/carbon steels and L and H grade steels. This analyzer transforms a traditional cart-mounted optical emission spectroscopy (OES) system into a highly portable, easy-to-use handheld analyzer.<div><h3>⚙️ Features &amp; Benefits</h3><ul><li>1064nm laser</li><li>WiFi enabled</li><li>Macro and micro cameras</li><li>Hot swap battery (Milwaukee Tool™ compatible)</li><li>Tilting, color touchscreen</li><li>Directional keys</li><li>Chamber pressure, spectral type, light/dark sensor safety interlocks</li><li>Password protected security</li><li>IP54 certified (splash/dust proof)</li><li>Reduced aperture &amp; compact tapered-nose design</li></ul><h3>🧪 Applications</h3><ul><li>Determine alloy composition and grade for a wide range of metallurgical samples</li><li>Calculate carbon equivalency to determine piping weldability</li><li>Verify critical assets, such as, piping, valves and reaction vessels for Positive Material Identification (PMI)</li><li>Inspect materials at receiving, in-process fabrication and outgoing Quality Control (QC)</li><li>Qualify Material Test Reports (MTR)</li><li>Prevent contaminated scrap from entering the supply stream</li><li>Detect tramp and trace elements to meet regulatory standards</li><li>Enhance productivity by measuring challenging structural shapes and sizes, including 1/4" piping, 1/4" bars, and larger weld wires</li><li>Maximize efficiency and bypass additional costs and time spent with on-site small-part measurement capabilities</li><li>Obtain unprecedented precision with a refined tapered nose and Argon seal, increasing shots per cylinder and return on investment</li></ul><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Niton_Apollo_Handheld_LIBS_Analyzer_5951f75476.jpg" alt="Thermo Scientific™ Niton™ Apollo™ Handheld LIBS Analyzer" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Niton_Apollo_Handheld_LIBS_Analyzer_5951f75476.jpg 156w," sizes="100vw" width="650" height="650"><h3>📏 Specifications</h3><ul><li>Analytical Range: C, Al, Si, Ti, V, Cr, Mn, Fe, Co, Ni, Cu, Nb, Mo, W</li><li>Argon Usage:&nbsp;<ul><li>High purity argon purge</li><li>About 200 shots per cartridge</li></ul></li><li>Available Analytical Modes: Stainless steel mode, Low alloy/carbon steel mode</li><li>Bluetooth: Bluetooth™ 4.0 (supports print functionality)</li><li>Camera:&nbsp;<ul><li>Integrated CCD macro camera for capturing overview images of parts and tagging measurement locations</li><li>Integrated CCD micro camera for locating and recording measurement positions</li></ul></li><li>Certifications/Compliance:&nbsp;<ul><li>Certifications: IP54 certified (splash and dust proof)</li><li>Compliance: CE, RoHS, FCC, Industry Canada, Safety to IEC 61010-1:2010</li></ul></li><li>Data Entry: Touchscreen keyboard User customizable data entry</li><li>Data Storage:&nbsp;<ul><li>512 MB internal system memory / 16 GB industrial grade storage</li><li>Stores approximately 5,000 readings with spectra (fewer if macro and micro images are saved)</li></ul></li><li>Data Transfer: WiFi, USB</li><li>Description: Niton Apollo Handheld LIBS Analyzer</li><li>Dimensions (L × W × H): 12 x 13 x 4 in (30.48 x 33.02 x 10.16 cm)</li><li>Display Type: Tilting, color, resistive touchscreen display</li><li>Global Positioning System: Internal GPS (ability to include coordinates with sample information)</li><li>Languages: English</li><li>Laser: 1064nm</li><li>Libraries:&nbsp;<ul><li>Default alloy libraries based on SAE, AISI, ASTM, AA, DIN, GB standards,&nbsp;</li><li>Users may create, clone and edit libraries</li></ul></li><li>Licensing: Varies by region. Contact your local distributor.</li><li>Operating Environment: Temperature: 32°F - 104°F (0°C - 40°C)</li><li>Operating System: Linux™</li><li>Optional Accessories:&nbsp;<ul><li>Thermo Scientific™ bulk argon adapter</li><li>Additional laser safety glasses</li></ul></li><li>Power Consumption: 24V, 3.75A, 90W power supply, Milwaukee Tool™ battery pack Hot swap functionality keeps analyzer powered during battery replacements</li><li>Safety Features: Chamber pressure, spectral type, light/dark sensor interlocks</li><li>Software: NitonConnect PC software</li><li>Standard Accessories:&nbsp;<ul><li>Locking shielded carrying case</li><li>Two (2) Milwaukee M18™ Redlithium™ High Demand™ CP2.0 battery packs</li><li>One (1) Milwaukee M18™ &amp; M12™ multi-voltage charger</li><li>Five (5) Thermo Scientific™ analytical argon cartridges</li><li>Setup standards</li><li>Laser safety glasses</li><li>Instrument cleaning kit</li><li>Safety lanyard and carabiner</li><li>PC connection cable</li></ul></li><li>Weight (English): 6.4 lbs with battery</li><li>Weight (Metric): 2.9 kg with battery</li><li>Applications: Identify low alloy/carbon, L grade, and H grade steels</li><li>Unit Size: Each</li></ul><blockquote><h3>Helpful links</h3><ul><li><a target="_blank" rel="noopener noreferrer" href="https://www.thermofisher.com/us/en/home/industrial/spectroscopy-elemental-isotope-analysis/portable-analysis-material-id/portable-xrf-analyzer-selection-guide.html">Which Niton analyzer is right for me?</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://www.thermofisher.com/us/en/home/industrial/spectroscopy-elemental-isotope-analysis/portable-analysis-material-id/portable-xrf-analyzer-rental-leasing.html">Should I rent or lease this product?</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://www.thermofisher.com/us/en/home/industrial/spectroscopy-elemental-isotope-analysis/portable-analysis-material-id/xrf-radiation-safety-training.html">Where can I get laser safety training?</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://www.thermofisher.com/us/en/home/industrial/spectroscopy-elemental-isotope-analysis/portable-analysis-material-id/industrial-elemental-radiation-solutions/how-does-libs-work.html">How does LIBS work?</a></li><li>What are the applications for this handheld LIBS analyzer?<ul><li><a target="_blank" rel="noopener noreferrer" href="https://www.thermofisher.com/us/en/home/industrial/spectroscopy-elemental-isotope-analysis/portable-analysis-material-id/portable-metal-manufacturing-inspection-recycling-solutions/positive-material-identification-oil-gas.html">Positive Material Identification</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://www.thermofisher.com/us/en/home/industrial/spectroscopy-elemental-isotope-analysis/portable-analysis-material-id/portable-metal-manufacturing-inspection-recycling-solutions/portable-manufacturing-metal-fabrication-analysis.html">Manufacturing and Metal Fabrication</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://www.thermofisher.com/us/en/home/industrial/spectroscopy-elemental-isotope-analysis/portable-analysis-material-id/portable-metal-manufacturing-inspection-recycling-solutions/portable-scrap-metal-recycling-analysis.html">Scrap Metal Recycling</a></li></ul></li><li><a target="_blank" rel="noopener noreferrer" href="https://www.thermofisher.com/us/en/home/industrial/spectroscopy-elemental-isotope-analysis/portable-analysis-material-id/industrial-elemental-radiation-solutions/niton-apollo-handheld-libs-analyzer-faqs.html">I have additional LIBS questions, where can I learn more?</a></li></ul></blockquote></div>

Thermo Scientific ARL 9900 Total Cement Analyzer

Combines XRF and XRD in one instrument for fast and precise analysis of cement materials. One sample, one analysis – full chemical and phase information.

Achieve excellent process control and save fuel in your cement plant with both chemical and phase analysis in one simple operation. The Thermo Scientific™ ARL™ 9900 Total Cement Analyzer combines X-Ray Fluorescence (XRF) and X-Ray Diffraction (XRD) technologies for a more complete characterization of any given crystalline sample.&nbsp;Various compounds can be controlled like quartz in raw meal, hot meal, free lime in clinker, clinker phases, and additions in cement (e.g. limestone, GBFS, pozzolan) or even clinker content in cement. Clinker phase analysis ensures consistent clinker quality, which is the key to high-performance concrete.The ARL 9900 Total Cement Analyzer provides fast process monitoring during the critical phases of cement manufacturing. It combines:<ul><li>XRF analysis – determines elemental composition</li><li>XRD analysis – provides mineralogical information</li></ul>Together, they ensure the integrity of the final product.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_ARL_9900_Intelli_Power_Series_3_75f234904f.jpg" alt="Thermo Scientific™ ARL™ 9900 Total Cement Analyzer: Integration of XRF and XRD in the same instrument: one sample, one instrument, one analysis for two techniques." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_ARL_9900_Intelli_Power_Series_3_75f234904f.jpg 237w," sizes="100vw" width="1143" height="753">Traditionally, both analyses required two separate X-ray instruments, leading to higher costs. Thanks to the compact integrated XRD system, both techniques are now included in one instrument, offering key benefits:<ul><li>Only one sample introduction – fast, simple, reliable</li><li>Single user interface for both techniques</li><li>Combined elemental and phase results in one report</li><li>Minimized floor space</li><li>Replaces two instruments</li><li>Rapid and precise analysis of solid samples</li></ul>IntelliPower: choose power level as needed – 1200W, 2500W, 3600W or 4200W Advanced software: instant result reporting after analysis Easy upgrades for future analytical needs<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_ARL_9900_Total_Cement_Analyzer_8c67ede30b.jpg" alt="Thermo Scientific™ ARL™ 9900 Total Cement Analyzer" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_ARL_9900_Total_Cement_Analyzer_8c67ede30b.jpg 165w," sizes="100vw" width="1626" height="1536"><h3>X-ray System</h3><ul><li>X-ray tube mounted above the sample – prevents damage (e.g. from fragile pellets)</li><li>Thermostatically regulated spectrometer – precise, sensitive, and stable measurements</li></ul><h3>Fixed Monochromators</h3><ul><li>Compact slit-crystal geometry – detects trace elements</li><li>Simultaneous multi-element analysis – for faster response</li></ul><h3>XRF Goniometers</h3><ul><li>Programmable for quantitative or qualitative element analysis</li><li>High-speed sequential X-ray spectrometry using Moire fringe technology</li><li>Handles nonroutine element analysis</li></ul><h3>Automation</h3><ul><li>Fast and reliable sample introduction, variable automation levels</li><li>Can be linked to automatic sample prep systems for online process control</li></ul>

Thermo Scientific™ GS Omni Analyzer

Thermo Scientific GS Omni uses PGNAA to provide continuous, calibration-free elemental analysis of process streams. Designed for demanding industrial slurry applications.

The Thermo Scientific™ GS Omni Light Element Analyzer provides robust, accurate elemental analysis for multiple process streams, delivering real-time information for the optimization of slurry beneficiation processes such as froth flotation. Utilizing industry-leading Prompt Gamma Neutron Activation Analysis (PGNAA) technology, it measures both heavy and light elements, crucially covering the Z&lt;20 elements – calcium and lighter – that are less well-suited to X-Ray Fluorescence (XRF) analysis. Together, Thermo Scientific PGNAA and XRF analyzers allow customers to measure the broadest possible range of elements.Since the PGNAA signal is unaffected by particle size, ore matrix or inter-element interference, the GS Omni requires no recalibration as the ore changes, enabling robust measurement with minimal cost and ongoing effort. Easily configured for between two and eight process streams, it provides data that you can confidently rely on. Use the GS Omni to control contaminant elements, improve product quality, increase recovery, and lower production costs.The GS Omni offers near metallurgical quality analysis for up to eight process streams, depending on concentration, elements of interest, required cycle analysis time, plant layout, and process control considerations.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_GS_Omni_Analyzer_927ddc6cd4.jpg" alt="Thermo Scientific™ GS Omni Analyzer" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_GS_Omni_Analyzer_927ddc6cd4.jpg 237w," sizes="100vw" width="650" height="427"><h3>🔑 Key features include:</h3><ul><li>Capability to measure light elements such as calcium, chlorine, sulfur, aluminum, silicon, magnesium, and sodium, for industrially relevant analysis over an extended range of elements relative to XRF.</li><li>Unaffected by matrix effects and particle size – unlike XRF – for robust measurements in the face of process changes and ore variability with no requirement for recalibration.</li><li>Scintillation detectors eliminate the need for cooling apparatus, enabling simpler set-up and operation with no requirement for chillers or special environmental control.</li><li>Modular multiplexer, for expansion from 2 to 8 streams.</li><li>Holding tank and sample recirculation through the measurement zone provide deaeration, which along with multiple passes through PGNAA source delivers more accurate measurement for slurry streams.</li><li>Factory calibrated for slurry applications with only infrequent site checks required, enabling minimal manual input and low maintenance.</li></ul>

Thermo Scientific MSA-330 Multi-Stream Slurry XRF Analyzer

Thermo Scientific MSA-330 (XRF) analyzer delivers elemental analysis (Ca–U) for up to 12 slurry streams, eliminating cross-contamination, with low operational cost and easy maintenance.

The Thermo Scientific™ MSA-330 Multi-Stream Slurry XRF Analyzer provides reliable, flexible, cost-effective elemental analysis for up to 12 slurry streams, delivering information for the monitoring and control (manual or automatic) of mineral beneficiation circuits. Keeping each stream in a separate analysis zone, it eliminates cross-contamination without any need for a multiplexer or demultiplexer, minimizing head loss and plant elevation requirements. Use the MSA-330 to monitor feed, concentrate and tailings grades, to drive up process efficiency, improve metal recovery, optimize reagent consumption, and reduce costs.The MSA-330 quantifies % solids and up to 20 elements for between 3 and 12 slurry streams according to a predefined schedule to deliver real-time process trend information for monitoring and control.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_MSA_330_Multi_Stream_Slurry_XRF_Analyzer_56ef33bd34.jpg" alt="Thermo Scientific™ MSA-330 Multi-Stream Slurry XRF Analyzer" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_MSA_330_Multi_Stream_Slurry_XRF_Analyzer_56ef33bd34.jpg 156w," sizes="100vw" width="650" height="650"><h3>Key features include:</h3><ul><li>Capability to measure and provide composite samples for 3 to 12 slurry streams, for flexible, cost-efficient process monitoring.</li><li>Dedicated, separate path for each process stream, from sample point to sample discharge, for the elimination of cross-contamination and simplified sample return.</li><li>Low head design simplifies sample transport design and is advantageous for gravity feed or return of samples to the process.</li><li>Advanced energy dispersive X-ray detector, for accurate measurement from calcium to uranium with integrated Peltier cooler for reliable, trouble-free operation over a wide range of in-plant environmental conditions.</li><li>Cross-cut sampler for each stream provides sampling for analyser calibration and composite samples.</li><li>Optional vacuum filter station available for each of the composite samplers.</li><li>When fed from a SamStat30C, the dedicated cross-cut samplers in the MSA-330 can be used to acquire composite samples for material balancing and accounting purposes.</li><li>No multiplexer or demultiplexer delivers a flow head space solution, lowering implementation and operational costs for a centralized analyser system.</li><li>High flow capability, for handling the full flow of low flowrate process streams, eliminating additional costs associated with a sampler and sample delivery system. 300mm wide tank as standard with larger sizes available for higher flow rates.</li></ul>

Thermo Scientific™ ARL™ SMS-XY Automation for XRF

The Thermo Scientific™ ARL™ SMS-XY XRF system enables unattended operation, sample prep and analysis with high quality, efficiency, and reduced cost.

<div><div><h4>Increase your capacity to handle more samples in less time.&nbsp;</h4>The Thermo Scientific™ ARL™ SMS-XY Automation for XRF permits continuous and unattended operation of<a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/products?instrumentationItems=100&amp;manufacturerItems=3&amp;search=9900"> Thermo Scientific™ ARL™ 9900 series X-ray Spectrometers</a>. Increased automation brings:&nbsp;<ul><li>Higher analysis quality</li><li>Lower analysis costs</li><li>Sustainable analysis cadence with predictable and reproducible response times</li><li>Short payback period</li></ul><h3>Automated Sample Handling</h3>The Thermo Scientific™ ARL™ OEM-XY automated sample loader allows connecting the <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/products/1211">ARL™ PERFORM'X</a> or <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/products?instrumentationItems=100&amp;manufacturerItems=3&amp;search=9900">ARL™ 9900</a> series to fully automatic preparation machines. Key features:<ul><li>Prepared samples (usually pressed pellets) are transported via belt conveyor from press to spectrometer</li><li>Unattended operation is ensured by engineering software supervision</li><li>Suitable for cement, metallurgy, and mining applications</li></ul></div><div><h3>Complete Automation with ARL SMS Software</h3>The ARL SMS software provides full automation of Thermo Scientific™ XRF spectrometers for routine production control, including sample preparation and analysis.<h3>Key Benefits:</h3><ul><li>Regular analysis of control samples with SPC evaluation for anomaly detection</li><li>Online connectivity for automatic sample preparation</li><li>Supports up to two sample transfer systems</li><li>Allows manual or online registration of externally prepared samples</li><li>Available as turnkey solution in ARL™ QuantoShelter cabin for production floor deployment</li><li>Seamless integration into quality control and production processes</li><li>Automatic result transmission after analysis</li></ul><h3>Compatible Sample Types:</h3><ul><li>Metallic samples (ferrous and non-ferrous)</li><li>Oxides from metal production (ores, sinters, baths, slags, blast furnace slags)</li><li>Oxides from minerals and cement</li></ul><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_ARL_SMS_XY_Automation_for_XRF_2_8bce1d83a2.jpg" alt="Thermo Scientific™ ARL™ SMS-XY Automation for XRF" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_ARL_SMS_XY_Automation_for_XRF_2_8bce1d83a2.jpg 179w," sizes="100vw" width="650" height="569"></div></div>

Thermo Scientific ARL SMS-Omega XRF Instrument

Boost production efficiency with fully automated XRF analysis. The ARL OPTIM'X with SMS-Omega ensures high-quality results with unattended prep, rapid WDXRF, and compact design.

Keep up with production demands with automated XRF analysis. When different types of material have to be processed in parallel, the <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/products/1212">Thermo Scientific™ ARL OPTIM'X™ WDXRF Spectrometer</a> with the Thermo Scientific™ ARL™ SMS-Omega XRF Instrument is the solution. Automatic sample preparation and handling without user intervention, combined with rapid analysis, provide high-quality results. This innovative solution has a compact footprint of less than 1 m², so it can be installed in centralized laboratories or on production shop floors, wherever fully automated industrial production control is needed.This cost-effective system is a unique combination of Thermo Scientific XRF and automation technology for fully automated sample preparation and analysis of one material type.<h3>Main Features</h3><ul><li>Unattended instrument monitoring and integrated audit trail functions</li><li>Sample handling arm equipped with a suction device (metals version) or a gripper (oxide version) loads samples for analysis.</li><li>Samples processed under strict identical and reproducible conditions</li><li>Fixed circular magazine</li><li>XRF functionality provided by the flexible and compact <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/products/1212">Thermo Scientific™ ARL™ OPTIM'X WDXRF </a>Instrument</li></ul><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_ARL_SMS_Omega_XRF_Instrument_2_ee38dccfef.jpg" alt="Thermo Scientific™ ARL™ SMS-Omega XRF Instrument " srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_ARL_SMS_Omega_XRF_Instrument_2_ee38dccfef.jpg 233w," sizes="100vw" width="650" height="435"><h3>Features of the OPTIM'X WDXRF Instrument</h3><ul><li>WDXRF platform with sequential and/or simultaneous capabilities</li><li>Configurable to cover all elements from fluorine (F) to uranium (U) in sequential mode</li><li>Fast analysis of solids, liquids and loose powders with superior spectral resolution</li><li>No water cooling or gas supply required (depending on configuration)</li><li>Closely coupled optics for increased intensity (50% higher than conventional geometry)</li></ul><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_ARL_OPTIM_X_WDXRF_Spectrometer_b264a3a303.jpg" alt="Thermo Scientific™ ARL™ OPTIM'X WDXRF Spectrometer" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_ARL_OPTIM_X_WDXRF_Spectrometer_b264a3a303.jpg 94w," sizes="100vw" width="650" height="1077"><h3>Features of the Fixed Circular Magazine</h3><ul><li>Eight positions for storing reference standards</li><li>Allows occasional manual introduction of prepared samples</li><li>One additional position dedicated to filing production samples following analysis</li><li>The complete system can also be supplied within a Thermo Scientific™ ARL™ QuantoShelter container for in situ analysis closer to the process.</li></ul><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_ARL_SMS_Omega_XRF_Instrument_87d53e64fb.jpg" alt="Thermo Scientific™ ARL™ SMS-Omega XRF Instrument" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_ARL_SMS_Omega_XRF_Instrument_87d53e64fb.jpg 216w," sizes="100vw" width="650" height="471">

Thermo Scientific ARL SMS-2300 Robotics-Based Automation for OES or XRF

Thermo Scientific™ ARL™ SMS-2300 enables fast, reproducible, and unattended OES/XRF analysis to optimize steel production and meet the strictest quality standards.

<h4>Meet stringent steel specifications while increasing efficiency and lowering production costs.</h4>The Thermo Scientific™ ARL™ SMS-2300 Robotics-Based Automation for OES or XRF is an automated quality control solution to optimize your steel production operation. With the high-performance ARL SMS-2300 system, even complex samples are prepared and analyzed under reproducible conditions without operator intervention, eliminating human variables and subjective factors. 👉 Result: Increased output, reliable results, and reduced costs.<h3>🔧 ARL SMS-2300 Automation for OES or XRF</h3>Provides ultimate power and flexibility for automatic, unattended 24/7 operation of:<ul><li>ARL™ 4460</li><li><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/products/1213">ARL™ iSpark</a> / <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/products/1977">iSpark Plus OES</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/products?instrumentationItems=100&amp;manufacturerItems=3&amp;search=9900">ARL™ 9900 XRF</a></li></ul><h3>✅ Main Features</h3><ul><li>Easy integration into fully automatic laboratories</li><li>Installed in ARL QuantoShelter, close to production process</li><li>Parallel tasking:<ul><li>Sample preparation</li><li>Sample introduction</li><li>Analysis</li><li>Instrument stand cleaning performed in hidden time</li></ul></li><li>High throughput with:<ul><li>Automatic sample preparation</li><li>Haas Mini Mill + ARL™ PrepControl™ + EasyPrep™ software</li></ul></li><li>Direct access to Haas Mini Mill for faster ferrous sample processing</li><li>Factory-configured and customized</li><li>Compact chassis, simple installation, and integrated electronics</li><li>High reliability, rapid ROI, and fast result availability</li><li>Frees lab personnel from routine tasks</li><li>ISO 9001 compliant manufacturing and maintenance</li></ul><h3>🚀 Advanced Technology</h3><ul><li>Fanuc industrial robot</li><li>OXSAS analytical software</li></ul>

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