Nutrient imbalances caused by industrial pollution were not affected by extreme climate events

A laboratory will occasionally have a poor performance in a PT scheme. When this occurs, the laboratory should acknowledge it, carry out an investigation and document a review of possible causes, even if it decides not to take any specific action. The purpose of this leaflet is to advise laboratories on how to best address such events. A good management of the poor performance in a PT can save you time and money.&nbsp;<h4>Evaluation of poor performance&nbsp;</h4>Every unsatisfactory performance score indicates a problem which needs to be investigated. In addition the laboratory should set its own criteria for launching an investigation with regards to other indicators of possible poor performance, such as questionable performance scores or observed trends.<h4>Root cause investigation&nbsp;</h4>The depth of the investigation will depend on several factors, such as the importance of the analysis, the frequency of unsatisfactory results and evidence of trends.&nbsp;The laboratory should check whether the PT report gives an explanation for the unsatisfactory performance. If no reason is provided, a stepwise approach is preferable to maximize the chances of determining the root cause of the problem. This approach is described in Annex B of the Eurachem Guide [1].<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Eurachem_How_to_investigate_poor_performance_in_proficiency_testing_Annex_B_be140d5b39.jpg" alt="Eurachem: How to investigate poor performance in proficiency testing - Annex B" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Eurachem_How_to_investigate_poor_performance_in_proficiency_testing_Annex_B_be140d5b39.jpg 153w," sizes="100vw" width="726" height="740">The investigation should consist of the following steps and involve the personnel that performed the analysis and where approporiate, also involve the laboratory management:&nbsp;<ol><li>Analyse the raw data, internal quality control data, any trend from previous PT rounds and the overall performance of the participants in that round;&nbsp;</li><li>After investigation is complete, make a plan for corrective action and consider implications for previous test results;&nbsp;</li><li>Execute and record the corrective action(s);&nbsp;</li><li>Check whether the corrective action(s) was effective.&nbsp;</li></ol><h4>Causes for poor performance&nbsp;</h4>The causes of poor performance can be grouped into three categories:&nbsp;<ol><li>Clerical errors are not directly linked to the laboratory’s technical competence, but can underline that the laboratory may have a potential problem when reporting results to its customers. Clerical errors can include transcription errors, mislabelling, incorrect units and decimal point errors. Identifying them is an important first step of an investigation. If such errors are a regular cause of poor performance, the investigation should focus on the related aspects of the quality management system.&nbsp;</li><li>Technical problems can occur at any step of the analytical procedure. If the investigation does not enable the laboratory to identify the root cause, it may be necessary to review the method validation.&nbsp;</li><li>Problems related to the PT scheme. Poor performance could also be due to the PT scheme not being entirely appropriate. The Eurachem Guide [1] provides information on selecting an appropriate PT scheme. In other cases, a problem may have occurred with the PT items. The laboratory is encouraged to discuss its findings with the PT provider.&nbsp;</li></ol>The “Fishbone diagram” or “5 Whys” are useful tools to investigate the root cause of a problem.<h4>Case studies&nbsp;</h4><h5>Example 1</h5>A medical laboratory has provided results in a PT scheme for tumor markers in serum with a 20 % deviation from the assigned value, although the daily internal controls performed well. The laboratory investigates the process and discovers the mistake was due to an incorrect unit conversion factor being introduced for PT results when the IT system was last updated. Since patient results are reported in a different unit than the one used by the PT provider no patient results were affected.&nbsp;<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Eurachem_How_to_investigate_poor_performance_in_proficiency_testing_0df20b3875.jpg" alt="Eurachem: How to investigate poor performance in proficiency testing" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Eurachem_How_to_investigate_poor_performance_in_proficiency_testing_0df20b3875.jpg 245w," sizes="100vw" width="1539" height="815"><h5>Example 2</h5>A laboratory performing food and feed analyses obtained poor performance scores on Listeria monocytogenes enumeration, because the number of microorganisms found was underestimated. Laboratory investigations showed an issue in incubation time and temperature applied by the analyst. The laboratory found that the analyst used an out-of-date procedure.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Eurachem_How_to_investigate_poor_performance_in_proficiency_testing_2_4e56101bbb.jpg" alt="Eurachem: How to investigate poor performance in proficiency testing" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Eurachem_How_to_investigate_poor_performance_in_proficiency_testing_2_4e56101bbb.jpg 245w," sizes="100vw" width="1185" height="526">

How to investigate poor performance in proficiency testing

Our Library never stops expanding. What are the most recent contributions to LabRulezICPMS Library in the week of 1st June 2026? Check out new documents from the field of spectroscopy/spectrometry and related techniques!<blockquote>👉 <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/library">SEARCH THE LARGEST REPOSITORY OF DOCUMENTS ABOUT SPECTROSCOPY/SPECTROMETRY RELATED TECHNIQUES</a></blockquote><blockquote>👉 Need info about different analytical techniques? Peek into <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/library">LabRulezLCMS</a> or <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library">LabRulezGCMS</a> libraries.</blockquote>This week we bring you technical note by Agilent Technologies, application note by Shimadzu and other document by Thermo Fisher Scientific!<h3>1. Agilent Technologies: Improving Resolution of Single Nanoparticles Using ICP-MS and Shorter Dwell Times</h3>Advantages of a 50 µs dwell time on a single nanoparticle’s signal profile&nbsp;<ul><li>Technical note</li><li><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/labrulez-bucket-strapi-h3hsga3/te_single_nanoparticle_9500_icp_qqq_5994_9127en_agilent_e47e21c8b4.pdf">Full PDF for download</a></li></ul>Single nanoparticles (sNPs) are defined as particles with diameters below 100&nbsp;nm. Owing to their distinct physical and chemical properties, engineered nanoparticles are incorporated into a wide range of products to enhance performance or functionality. At the same time, they are increasingly recognized as potential contaminants or pollutants. In the semiconductor industry, for example, even single-digit nanometer-sized sNPs present in process chemicals can cause electrical shorting to occur and reduce product yield. Although the effects of sNPs on environmental and biological systems are still being investigated, researchers have developed methods to determine sNPs using single particle-ICP-MS (spICP-MS).1 Agilent ICP-MS instruments are widely used to characterize sNPs because of their fast-scanning multi-element capability, ultra-high sensitivity, low background, and integrated data analysis software.2-5sNPs are decomposed, atomized, and ionized in the high-energy ICP. Any ions that are generated from a particle enter the vacuum chamber as ion clusters and are then detected as transient signal peaks above the background signal. The signal from each sNP event usually lasts between 400 and 1,300 µs. To detect this short-lived signal with high resolution, a fast time-resolved analysis (fast-TRA) acquisition is employed. Typically, a default dwell time of 100 µs is used. However, if higher peak resolution is required, the Agilent 9500 Triple Quadrupole ICP-MS (ICP-QQQ) can be operated with a dwell time as low as 50 µs. During the development of the 9500 ICP-QQQ, improvements to the instrument’s hardware enabled reliable control of TRA at much shorter timing intervals. These enhancements enable the 9500 to operate with high stability at a 50&nbsp;µs dwell time, making it an effective instrument for high-resolution sNP analysis. The robust plasma of Agilent ICP-MS instruments, as indicated by a CeO+ /Ce+ ratio &lt; 1%, also reduces matrix effects between standards and samples.&nbsp;In this study, we conducted a fundamental evaluation of sNP analysis using a dwell time of 50 µs. Gold (Au), silica (SiO2 ), and platinum (Pt) nanoparticles were analyzed by the 9500 ICP-QQQ, and the results were compared with those obtained with a 100 µs dwell time.<h4>Experimental&nbsp;</h4><h5>Instrumentation&nbsp;</h5>The <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/library?mainauthorItems=10&amp;search=+9500+ICP-QQQ">Agilent 9500 ICP-QQQ</a> used the standard configuration (Ni cones and u-lens), except for the torch. A quartz torch with a 1.5 mm inner diameter (id) injector was used to minimize diffusion of ion clusters in the ICP and obtain sharper, better-resolved peaks.&nbsp;Multi-element NP data acquisition and analysis were carried out using the Rapid Multi-Element Nanoparticle Analysis mode of the optional Single Nanoparticle Application Module for the Agilent OpenLab ICP-MS software. In Rapid MultiElement Nanoparticle Analysis mode, multi-element data are collected sequentially from a single sample acquisition, and all data are combined into a single file. This method saves time, as only one sample uptake and rinse are needed for all analytes. Data quality is likely enhanced, since the risk of sample contamination is considerably lower with a single analysis than with multiple separate analyses.<h4>Conclusion&nbsp;</h4>For high-resolution nanoparticle analysis, the Agilent 9500 ICP-QQQ can be operated in single-particle mode with a 50 µs dwell time, as well as the default 100&nbsp;µs setting. The reduction of dwell time is enabled by advancements in both hardware and software that work together to support higher-resolution single-nanoparticle measurements.&nbsp;Improved peak resolution was demonstrated for Au, SiO2 , and Pt nanoparticles, while maintaining equivalent performance to the standard 100&nbsp;µs dwell time setting. The mean particle sizes obtained at 50&nbsp;µs for the nanoparticle suspensions were within the manufacturer’s certified ranges. Likewise, the particle size distributions measured at both 50 and 100&nbsp;µs closely matched the distributions provided by the manufacturer.&nbsp;In addition to improved peak resolution, a shorter dwell time reduces the likelihood of multiple particles being detected within a single dwell period, potentially improving data accuracy.&nbsp;Since the total data volume increases inversely with dwell time, a 50 µs dwell time generates more data points per unit time. To reduce processing time when handling large datasets, Agilent ICP-MS software (both ICP-MS MassHunter and OpenLab ICP-MS) uses multithreaded CPU‑based computation for sNP data analysis, maintaining efficient data management.Although 50&nbsp;µs may not be necessary for many sNP analyses, having the option to use this shorter dwell time provides greater flexibility. For example, it could enable samples with unexpectedly high particle counts to be analyzed without needing additional dilution.<h3>2. Shimadzu: 3D-DIC Analysis in Compression Test of Glass Tube</h3><ul><li>Application note</li><li><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/labrulez-bucket-strapi-h3hsga3/an_01_01052_en_fd73dc76a6.pdf">Full PDF for download</a></li></ul><h4>User Benefits</h4><ul><li>The HPV-X3 high-speed video camera has resolution three times higher than the conventional device, resulting in improved analysis performance in DIC analyses.</li><li>The HPV-X3 high-speed video camera allows recording at a maximum framerate of 20 Mfps, two times faster than the conventional device.</li><li>Three-dimensional displacement measurement is possible by synchronous recording using two HPV-X3 high-speed video cameras and 3D-DIC analysis.</li></ul>Glass is used in various industries, such as electronic devices and automobiles. Depending on the intended application, mechanical properties are measured by material testing, but to achieve further improvements in performance, it is necessary to observe the origin of fracture and the condition of crack propagation. However, glass displays brittle fracture behavior, which is difficult to observe visually. In our previous reports, we observed the fracture behavior of glass specimens in ring-on-ring tests 1, 2, and those observation results indicated that a high-speed video camera with a recording speed (framerate) of several Mfps or higher is required to observe the fracture behavior of glass. In this experiment, the fracture behavior of a glass tube during a compression test was observed with an HPV-X3 high-speed video camera. In addition, synchronous videorecording was carried out using two HPV-X3 cameras, and the strain distribution during fracture was visualized by a 3D-DIC (three-dimensional digital correlation) analysis.<h4>Specimen Information and Measurement System</h4>The glass tube used as the specimen was compressed in the axial direction using an AGX-V2 precision universal testing machine. Table 1 and Table 2 show the equipment configuration and the specimen dimensions, respectively. In this article, fracture observation in the compression test and visualization of the strain distribution by 3D-DIC analysis were carried out. Fig. 1 shows the condition of the test for the 3D-DIC analysis. When an observation target such as a glass tube has a curved shape, a 3- dimensional strain analysis is necessary. Therefore, synchronous recording from two directions was conducted using two<a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/library?mainauthorItems=1&amp;search=+HPV-X3"> HPV-X3</a> high-speed video cameras, with a random pattern drawn on the specimen surface, as shown in Fig. 2. Table 3 shows the recording conditions.<h4>Conclusion&nbsp;</h4>The fracture of a glass tube during a compression test was observed using two HPV-X3 high-speed video cameras, and a 3D-DIC analysis was carried out. In fracture observation, the crack that became the origin of fracture could be identified, and the condition of crack propagation was clearly captured. In the 3D-DIC analysis, it was possible to observe the concentration of strain in front of the crack and the decrease in strain after crack propagation. Since glass fracture is brittle and is extremely rapid, a high-speed video camera with a recording speed of 5 Mfps or higher, such as the HPV-X3, is an effective instrument for fracture observation.<h3>3. Thermo Fisher Scientific: How can you maximize productivity in lightweight metal scrap sorting?</h3><ul><li>Other document</li><li><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/labrulez-bucket-strapi-h3hsga3/maximize_productivity_in_lightweight_metal_scrap_sorting_sn1546_en_2cca0f44fe.pdf">Full PDF for download</a></li></ul>Handheld XRF (HHXRF) has long been an important tool for sorting scrap metals. While handheld XRF can identify most grades of stainless steel, as well as titanium, nickel, cobalt, and copper alloys within 1 to 2 seconds, sorting aluminum alloys can take significantly longer. This is especially true if those alloys cannot be specifically identified by the content of their transition metals, such as manganese, copper zinc, nickel, iron chromium or titanium. The separation of grades within the AA 1000, AA 5000 and AA 6000 series, as well as casting alloy family grade separation, requires the measurement of light elements such as magnesium or silicon. Those elements are generally measured using an X-ray beam with a lower voltage, which results in longer measurements of typically 10&nbsp;seconds or more. About a decade ago, handheld laser-induced breakdown spectroscopy (LIBS) emerged as an alternative for sorting aluminum and magnesium alloy grades within a few seconds. These include the smaller spot size and fluctuations related to the transient nature of the laser-induced plasma. Compared to a wider, continuous beam of X-rays, LIBS analysis is intrinsically more sensitive to surface roughness and surface contamination, and thus less precise than HHXRF.&nbsp;More recently, the Light Metal Quick Sort (LMQS) mode available on the <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/products/1992">Thermo Scientific™ Niton™ XL5 series of handheld XRF analyzers </a>uses a different logic than conventional HHXRF instruments. Provided with a 5W (up to 500µA) tube and a stateof-the-art silicon drift detector (SDD) with a graphene window, the analyzer starts measuring, at low voltage, elements from magnesium to zinc. This enables identification of most aluminum and magnesium alloy grades within one to three seconds, as well as the identification of other families of alloys. Longer measurements can be set for the few aluminum alloy grades that are identified based on zirconium, tin, lead, or bismuth contents.

News from LabRulezICPMS Library - Week 23, 2026

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Eurachem is a European network promoting international traceability of chemical measurements and good analytical practice. It provides expert guidance, supports method validation, uncertainty evaluation, proficiency testing, and facilitates discussion on technical and policy issues in analytical quality.

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Thermo Scientific ARL 9900 IntelliPower Series

Powerful WDXRF analyzer with optional XRD for real-time elemental and phase analysis of solids. Configurable with up to 32 channels and 3 goniometers for fast, precise process control.

The Thermo Scientific™ ARL™ 9900 IntelliPower Series spectrometer is a powerful and versatile WDXRF analyzer with optional integrated XRD, designed for high-performance, real-time process control in demanding industrial environments. It enables rapid, precise, and fully automated elemental and phase analysis of solid samples such as metals, cement, and minerals.With up to 32 fixed monochromators and one to three gearless goniometers, the ARL 9900 performs both simultaneous and sequential elemental analysis across a wide range—from boron to americium (Z=5–95). It can be enhanced with a compact X-ray diffraction (XRD) module to deliver phase-specific data, such as free lime content, clinker phases, and iron compounds in DRI processes.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_ARL_9900_Intelli_Power_Series_3_75f234904f.jpg" alt="Thermo Scientific™ ARL™ 9900 IntelliPower Series: Integration of XRF and XRD in the same instrument: one sample, one instrument, one analysis for two techniques." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_ARL_9900_Intelli_Power_Series_3_75f234904f.jpg 237w," sizes="100vw" width="1143" height="753"><h3>Applications</h3><ul><li>Metals: iron, steel, aluminum, copper, zinc, nickel, titanium, magnesium alloys, slags, and sinters</li><li>Cement: raw meal, clinker, free lime, clinker phases, limestone, additives</li><li>Mining &amp; Minerals: ores, rocks, beach sands, sediments, industrial minerals</li><li>Other Materials: ceramics, glass, polymers, soils</li><li>By-products: process residues and waste materials</li></ul><h3>Key Features</h3><ul><li>Fully integrated simultaneous and sequential WDXRF analysis in one instrument</li><li>Configurable with up to 24 fixed channels and one or more goniometers for ultra-fast, high-precision analysis</li><li>Rapid and reliable sample introduction system with multiple automation levels</li><li>Wide detection range: from parts per million (ppm) to 100% concentration</li><li>LoVap™ X-ray tube with 50 μm Be window for long-term stability and enhanced performance</li><li>Modular IntelliPower platform available in 1500 W, 2500 W, and 4200 W configurations</li><li>Ultra-low detector gas consumption</li><li>Optional integrated XRD module for qualitative and quantitative phase analysis</li><li>Scalable design to meet evolving analytical requirements</li><li>Factory calibration ensures fast commissioning and immediate operational readiness</li></ul><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_ARL_9900_Intelli_Power_Series_e194c316bb.jpg" alt="Thermo Scientific™ ARL™ 9900 IntelliPower Series" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_ARL_9900_Intelli_Power_Series_e194c316bb.jpg 128w," sizes="100vw" width="650" height="795"><h3>X-ray System</h3><ul><li>X-ray tube mounted above the sample: protects the system from fragile or damaged samples</li><li>Thermostatically regulated spectrometer: ensures consistent analytical conditions and excellent measurement stability</li></ul><h3>Fixed Monochromators</h3><ul><li>Up to 32 fixed channel monochromators for full simultaneous operation</li><li>Compact slit-crystal geometry: optimized for low detection limits and rapid analysis of dedicated elements</li></ul><h3>XRF Goniometers</h3><ul><li>Programmable for both quantitative and qualitative analysis</li><li>Moiré fringe technology ensures fast, gearless sequential X-ray spectrometry with excellent angular precision</li><li>SmartGonio: compact system covering F to Am with up to 3 crystals</li><li>Universal goniometer: extended coverage from B to Am with up to 9 crystals and 4 collimators</li></ul><h3>Calibration Options</h3><ul><li>Fully factory-calibrated for a broad range of sample types including: cast irons, steels, brasses, bronzes, copper, aluminum, zinc, tin, magnesium, nickel, titanium, cobalt, ferro-alloys, cement, minerals, slags, limestone, ceramics, glass, soils, sediments, rocks, and polymers</li><li>XRD calibrations available for: free lime, clinker phases (C3S, C2S, C3A, C4AF), amorphous content in clinker, DRI phases, and more</li></ul><h3>Automation</h3><ul><li>Fast and dependable sample introduction with scalable automation</li><li>Compatible with ARL SMS systems for fully automated online process control, including integrated sample preparation</li></ul>

Thermo Scientific ARL 9900 Total Cement Analyzer

Combines XRF and XRD in one instrument for fast and precise analysis of cement materials. One sample, one analysis – full chemical and phase information.

Achieve excellent process control and save fuel in your cement plant with both chemical and phase analysis in one simple operation. The Thermo Scientific™ ARL™ 9900 Total Cement Analyzer combines X-Ray Fluorescence (XRF) and X-Ray Diffraction (XRD) technologies for a more complete characterization of any given crystalline sample.&nbsp;Various compounds can be controlled like quartz in raw meal, hot meal, free lime in clinker, clinker phases, and additions in cement (e.g. limestone, GBFS, pozzolan) or even clinker content in cement. Clinker phase analysis ensures consistent clinker quality, which is the key to high-performance concrete.The ARL 9900 Total Cement Analyzer provides fast process monitoring during the critical phases of cement manufacturing. It combines:<ul><li>XRF analysis – determines elemental composition</li><li>XRD analysis – provides mineralogical information</li></ul>Together, they ensure the integrity of the final product.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_ARL_9900_Intelli_Power_Series_3_75f234904f.jpg" alt="Thermo Scientific™ ARL™ 9900 Total Cement Analyzer: Integration of XRF and XRD in the same instrument: one sample, one instrument, one analysis for two techniques." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_ARL_9900_Intelli_Power_Series_3_75f234904f.jpg 237w," sizes="100vw" width="1143" height="753">Traditionally, both analyses required two separate X-ray instruments, leading to higher costs. Thanks to the compact integrated XRD system, both techniques are now included in one instrument, offering key benefits:<ul><li>Only one sample introduction – fast, simple, reliable</li><li>Single user interface for both techniques</li><li>Combined elemental and phase results in one report</li><li>Minimized floor space</li><li>Replaces two instruments</li><li>Rapid and precise analysis of solid samples</li></ul>IntelliPower: choose power level as needed – 1200W, 2500W, 3600W or 4200W Advanced software: instant result reporting after analysis Easy upgrades for future analytical needs<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_ARL_9900_Total_Cement_Analyzer_8c67ede30b.jpg" alt="Thermo Scientific™ ARL™ 9900 Total Cement Analyzer" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_ARL_9900_Total_Cement_Analyzer_8c67ede30b.jpg 165w," sizes="100vw" width="1626" height="1536"><h3>X-ray System</h3><ul><li>X-ray tube mounted above the sample – prevents damage (e.g. from fragile pellets)</li><li>Thermostatically regulated spectrometer – precise, sensitive, and stable measurements</li></ul><h3>Fixed Monochromators</h3><ul><li>Compact slit-crystal geometry – detects trace elements</li><li>Simultaneous multi-element analysis – for faster response</li></ul><h3>XRF Goniometers</h3><ul><li>Programmable for quantitative or qualitative element analysis</li><li>High-speed sequential X-ray spectrometry using Moire fringe technology</li><li>Handles nonroutine element analysis</li></ul><h3>Automation</h3><ul><li>Fast and reliable sample introduction, variable automation levels</li><li>Can be linked to automatic sample prep systems for online process control</li></ul>

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News from LabRulezICPMS Library - Week 23, 2026

How to investigate poor performance in proficiency testing

Nutrient imbalances caused by industrial pollution were not affected by extreme climate events