In the eukaryotic nucleus, DNA is wrapped around highly basic proteins called histones thereby forming a basic DNA storage unit – the nucleosome. Histone covalent modifications (methylation) represent an essential mechanism for the regulation of expression of specific genes in living organisms. Small changes in this highly regulated system, occurring in an abnormal position or place, often lead to disease. However, the molecular mechanisms of the recognition of various states of particular marks are not entirely understood.
Scientists led by <a href="https://www.uochb.cz/en/directory/298/vaclav-veverka">Václav Veverka</a> from <a href="https://icpms.labrulez.com/companies/62">IOCB Prague</a> and Charles University, together with colleagues from <a href="https://icpms.labrulez.com/companies/36">CEITEC</a>, the Institute of Microbiology of the CAS, and the University of Cologne studied the chromatin reader LEDGF and its association with methylated histone H3K36, which is known as a marker of active transcription.
The researchers employed cryo-EM coupled with NMR spectroscopy to dissect both structured and dynamic regions of LEDGF protein involved in reading the methylated nucleosomes.
They have structurally validated that the readout of both di- and trimethylated nucleosomes is mechanistically versatile.
<blockquote>
<h5>“*The structural conservation of differently methylated histones might not be as surprising, but we have also identified an alternative binding site for LEDGF on a nucleosome, independent of the degree of methylation.*”</h5>
<ul>
<li>Eliška Koutná, the first author of the study</li>
</ul>
</blockquote>
Moreover, with NMR they have also discovered that disordered regions in LEDGF that interact with DNA preferentially interact with extranucleosomal DNA but are still flexible in the context of dinucleosome.
<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/UOCHB_Insight_into_the_nucleosome_recognition_mechanisms_Structure_of_the_PWWP_domain_from_LEDGF_bound_to_H3_K36_trimetylated_dinucleosome_99e0424c39.jpg" alt="ÚOCHB - Insight into the nucleosome recognition mechanisms - Structure of the PWWP domain from LEDGF bound to H3K36 trimetylated dinucleosome.jpg"/>
These results were published in the journal Nucleic Acids Research with <a href="https://www.uochb.cz/en/directory/745/eliska-koutna">Eliška Koutná</a> as the first author.

Insight into the nucleosome recognition mechanisms

Plastics and microplastics are all around us. They appeared in the 1950s and have become part of our everyday reality. We build with plastic, wear it, transport in it, and wrap our food in it. However, more and more questions are arising about this material with many practical properties. Microplastics are found practically everywhere; in water, soil, and air. But how do microplastics actually interact with the human body? What impact do they have on our environment and our health? Is it true that they penetrate places like the brain or placenta? And if so, what does that actually mean? Just like elsewhere in the world, these and many other questions related to plastics occupy the minds of many scientists in the Czech Republic, including one directly at the RECETOX center.Ondřej Adamovský is an environmental toxicologist who has long been involved in the issue of plastics and microplastics at the <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/companies/19">RECETOX center</a>. Although his research scope is broader, he is currently focusing primarily on developing new methods within the <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/companies/36">CEITEC VUT</a>, University of Ljubljana, and Technical University of Vienna <a target="_blank" rel="noopener noreferrer" href="https://planterastics.fkkt.uni-lj.si/plastsensing/">consortium</a> to unequivocally prove the presence of microplastics in the human body and organisms. Despite the hundreds of articles published annually warning about microplastics, a&nbsp;serious method to truly prove their presence in the human body is still lacking.“Scientific articles that are now widely appearing and reporting that microplastics have been found in lungs, placenta, brain, or penises raise the question of how they could have gotten there. Unlike chemical substances, which are soluble, microplastics are solid particles, and those above a&nbsp;certain size cannot pass through biological barriers and move within the body. From this perspective, our current project is very beneficial because the newly developed methods for detecting microplastics will provide very precise information about what sizes and types of microplastics are capable of migrating within the human body,” explains Ondřej Adamovský.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/RECETOX_Mikroplasty_jako_castice_jsou_stale_otevrene_tema_nicmene_rizika_spojena_s_jejich_aditivy_zname_rika_environmentalni_toxikolog_Ondrej_Adamovsky_8a41ab5c09.jpg" alt="RECETOX: Microplastics as particles are still an open topic, but the risks associated with their additives are known, says environmental toxicologist Ondřej Adamovský" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_RECETOX_Mikroplasty_jako_castice_jsou_stale_otevrene_tema_nicmene_rizika_spojena_s_jejich_aditivy_zname_rika_environmentalni_toxikolog_Ondrej_Adamovsky_8a41ab5c09.jpg 234w," sizes="100vw" width="1200" height="800">The ability of particles to migrate through tissues raises the most questions. While the conclusions of scientific articles pointing out the findings of microplastics in the lungs, where microplastics can get, for example, by inhalation from the surrounding environment, are quite logical, the findings of microplastics in internal organs (brain, penises, or placentas) require a&nbsp;great deal of scientific scrutiny.“These studies are scientifically questionable and need to be read in detail. Specifically, in a&nbsp;recent, media-friendly study that found microplastics in penis biopsies, it is stated that microplastics in the tissue can be one hundred to five hundred micrometers in size, which is basically the size of a&nbsp;grain of sand. The claim that solid particles of this size could pass through the digestive tract, overcome biological barriers into the blood, and accumulate somewhere is absolutely excluded and scientifically questionable,” says Adamovský.How is this possible then? The most likely explanation for the presence of microplastics in the samples is secondary contamination. Given that microplastics are all around us, they most likely got into the samples simply during handling. For example, the mentioned research on the presence of microplastics in various human organs takes place in several locations, from the operating room, the sample processing site, to the place where the analyses are performed. Even though these are always clean rooms, microplastics are ubiquitous, and the fact that microplastics are also part of dust contributes to contamination.“In the case of the study with placentas, the mechanism of unintended contamination may be similar. The placenta is delivered, then taken somewhere, samples are cut from it, and if proper procedural steps and controls are not in place, it is impossible to say that the plastic comes directly from the organ and did not get into the sample later,” explains Adamovský.The new method that the scientist is now working on with a&nbsp;team of other researchers is instead based on the use of computer tomography, which works with intact tissues. Therefore, it is not necessary to disrupt or interfere with them in any way for their examination, thus minimizing the risk of secondary contamination. Based on in vivo models, scientists will look at what microplastics, what sizes, and in what places can be deposited in the organism. The larger vision is then to use human samples and analyze microplastics in tissues through biopsy. According to Adamovský, only then will we have truly indisputable proof that microplastics can move across tissues and subsequently accumulate in them.“Another problem with articles and reports is that despite the enormous amount of histopathological observations made since the 1950s, doctors have not found microplastics anywhere. Ten, twenty, fifty, or one hundred micrometers, these are large plastics visible under a&nbsp;microscope. However, no one has ever recorded them during observations, which is strange. This fact suggests that the articles are not well done, and until someone provides a&nbsp;methodology, like the one we are currently working on, all other research is very easily questionable,” claims Adamovský.Although it seems there is not much to worry about yet, monitoring the risks associated with microplastics is more than essential. If their presence in human tissues is indeed proven, it will be necessary to further investigate their effects on human health. The issue of plastics also has another dimension, which is their chemical composition.“It can be said that microplastics as particles are still an open and researched topic, but plastic additives, i.e., the chemical substances contained in them, have been tested for a long time, and their risks are known. For example, the group of phthalates1, which we also studied here at RECETOX, was found to be so dangerous that they were globally banned in 2022,” adds Adamovský.Fortunately, legislation in the context of microplastics is progressing. Over the past five years, the European Union has issued regulations banning the use of microplastics in cosmetic products or consumer products, which will help reduce their emissions into the environment2.“Microplastics have already disappeared, for example, from shampoos, where they were added as exfoliants, and certain types of plastics were also used in mascaras or cosmetic fillers. Compared to the United States, this measure came later, but it is more thorough, as it will also apply to so-called leave-on cosmetics, such as sunscreens or cleansing facial gels, which is not the case in America,” explains Adamovský.<div style="text-align:left;"><div><div><div><div id="cib-chat-main"><div><div aria-description="" aria-label="Sent by Copilot: Here is the translation:

**Even smaller particles, but an even bigger problem, are nanoplastics. These plastic particles are so small that no visual technique can capture them. Therefore, their study is challenging, and very little is known about nanoplastics so far.**

**&quot;Detection methods are very poor, they basically do not exist. So far, we know that nanoplastics, unlike microplastics, can pass through biological barriers, but the question is what they can cause. There are initial studies showing that nanoplastics can induce pro-inflammatory states,&quot; warns Adamovský.**

**The overarching root problem of microplastics and nanoplastics is, first and foremost, plastics themselves. As the name suggests, microplastics are formed during their degradation. In practice, these particles get into soils, for example, by the breakdown of protective plastic films used to protect agricultural areas against weeds or water evaporation. Another significant area where microplastics are released through degradation is food production and packaging.**

**&quot;Ninety percent of all packaging materials are plastics. It doesn't matter whether we take yogurt, meat, or vegetables, if they are in plastic packaging, microplastics will also be present in them. However, they do not only get into them from the packaging. The food production process almost always involves a&nbsp;phase where plastic is used, whether it is plastic pipes, containers, or another part of the production. Microplastics thus penetrate products primarily during production, and so we find them even in beverages in glass bottles, aluminum packaging, salt, oils, or honey. There is no large-scale production that can do without the use of plastic components,&quot; describes Adamovský.**

If you need any further assistance, feel free to ask! 😊"><div><div>Even smaller particles, but an even bigger problem, are nanoplastics. These plastic particles are so small that no visual technique can capture them. Therefore, their study is challenging, and very little is known about nanoplastics so far.“Detection methods are very poor, they basically do not exist. So far, we know that nanoplastics, unlike microplastics, can pass through biological barriers, but the question is what they can cause. There are initial studies showing that nanoplastics can induce pro-inflammatory states,” warns Adamovský.The overarching root problem of microplastics and nanoplastics is, first and foremost, plastics themselves. As the name suggests, microplastics are formed during their degradation. In practice, these particles get into soils, for example, by the breakdown of protective plastic films used to protect agricultural areas against weeds or water evaporation. Another significant area where microplastics are released through degradation is food production and packaging.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/RECETOX_Ondrej_Adamovsky_CELSPAC_Setkani_generaci_na_Festivalu_vedy_de415019b9.jpg" alt="RECETOX: Ondřej Adamovský (CELSPAC Meeting of generations at the Science Festival)" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_RECETOX_Ondrej_Adamovsky_CELSPAC_Setkani_generaci_na_Festivalu_vedy_de415019b9.jpg 234w," sizes="100vw" width="1500" height="1001">“Ninety percent of all packaging materials are plastics. It doesn’t matter whether we take yogurt, meat, or vegetables, if they are in plastic packaging, microplastics will also be present in them. However, they do not only get into them from the packaging. The food production process almost always involves a&nbsp;phase where plastic is used, whether it is plastic pipes, containers, or another part of the production. Microplastics thus penetrate products primarily during production, and so we find them even in beverages in glass bottles, aluminum packaging, salt, oils, or honey. There is no large-scale production that can do without the use of plastic components,” describes Adamovský.</div></div></div></div></div></div></div></div></div><div><div style="text-align:left;"><div>For plastics in their versatile use today, there is no sufficient alternative. However, there are ways to at least mitigate their impact. One proposed measure is the unification of the allowed composition of plastics. This would allow plastics to be returned to the economic cycle, i.e., recycled.“Currently, each plastic is completely different and full of various additives. You can’t even combine two plastic cups from different brands; it’s an unidentifiable mix used only by specific manufacturers. This is why plastic packaging is recycled into building materials3, but this type of product is permanent and does not return to the circular economy,” explains Adamovský.The Czech Republic is also looking for ways to improve the dire situation with plastics. A&nbsp;team of researchers, with whom Ondřej Adamovský is now seeking new methods for detecting microplastics, has commented on the Global Plastics Treaty for the Ministry of the Environment. This treaty should help with the current one-way flow of plastics that end up in waste without the possibility of recycling.“Currently, mainly PET bottles are recycled because they have no additives; they are more or less the same. This is a&nbsp;big exception; most other plastics are usually burned. This treaty aims to ensure that the vast majority of plastics somehow return to circulation and become part of the circular economy. We can contribute to treaties related to plastics with our expertise, specifically an overview of the bioactivities of chemicals contained in plastics,” explains Adamovský.What is currently missing at the level of political negotiations in the Czech Republic is a&nbsp;foundation or association that would create a&nbsp;counterbalance to the industry in discussions about national implementations. An example of such good practice could be the <a target="_blank" rel="noopener noreferrer" href="https://www.foodpackagingforum.org/">Food Packaging Forum.</a></div></div><div><div><div>“The Food Packaging Forum is an entity that the government can turn to for verifying information or consulting on planned measures. They are capable of gathering scientific evidence or data that is publicly available and drawing clear and substantiated conclusions from it. Global treaties are generally very broad, and their implementation is entirely up to the governments of individual states. This kind of support is currently missing in the Czech Republic, and that is a&nbsp;shame,” summarizes Adamovský.</div></div></div></div>

Microplastics as particles are still an open topic, but the risks associated with their additives are known, says environmental toxicologist Ondřej Adamovský

To honor the memory of <a target="_blank" rel="noopener noreferrer" href="https://icpms.cz/articles?search=Vladim%C3%ADr+Sklen%C3%A1%C5%99">Prof. Vladimír Sklenář</a>, an internationally renowned scientist and an important organizer of scientific activities in the Czech Republic, CEITEC Masaryk University is introducing the Vladimír Sklenář Scholarship.The scholarship is intended for students of doctoral studies at universities in the Czech and Slovak Republics working in the field of NMR spectroscopy, and can be used to cover the costs related to their studies.The intention is to strengthen and improve the quality of studies, as well as personal and career development.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/MUNI_CEITEC_Vladimir_Sklenar_Scholarship_f1b59aec0f.jpg" alt="MUNI/CEITEC: Vladimír Sklenář Scholarship" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_MUNI_CEITEC_Vladimir_Sklenar_Scholarship_f1b59aec0f.jpg 110w," sizes="100vw" width="738" height="1044">The scholarship in the amount of CZK 100,000, which may be taxable according to the practice of the institution and/or the tax regulations of the beneficiary's&nbsp;country, is sponsored by <a rel="noopener" target="_blank">Měřící technika Morava</a>. The scholarship will be awarded to one person per year.The deadline for applications for the 2025 scholarship has been set for 28&nbsp;February&nbsp;2025. &nbsp;

Vladimír Sklenář Scholarship

Brno is at the global forefront of electron microscopy. It draws primarily from the legacy of the scientist, physicist, and university lecturer Armin Delong, whose influence remains strong at Brno University of Technology (BUT), where the globally recognized physicist studied and received an honorary doctorate in 2014. The university considers electron microscopy as its strategic area and engages in research, teaching, and popularization activities in this field.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/VUT_v_Brne_Armin_Delong_pri_prebirani_cestneho_doktoratu_na_VUT_2014_2e43f52f12.jpg" alt="BUT Brno archive: Armin Delong receiving an honorary doctorate at BUT, 2014" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_VUT_v_Brne_Armin_Delong_pri_prebirani_cestneho_doktoratu_na_VUT_2014_2e43f52f12.jpg 235w," sizes="100vw" width="1600" height="1067"><h3>A pioneer of technology and science associated with BUT</h3>Armin Delong was born on 29 January 1925 in Bartovice, Ostrava, and passed away on 5 October 2017 in Brno. He was drawn to technology from an early age, building radios and transmitters and conducting physics experiments. His life was closely intertwined with the history of BUT. Immediately after the war, he began studying at the then Czechoslovak Technical University of Eduard Beneš, where he worked as a research assistant and assistant to Professor Aleš Bláha at the Institute of Theoretical and Experimental Electrical Engineering, Faculty of Electrical Engineering and Communication (FEEC&nbsp;BUT). He also served as the long-time director of the Institute of Instrumentation Technology at the Czechoslovak Academy of Sciences and between 1967 and 1971 led the Department of Solid-State Physics at the Faculty of Science, Masaryk University.As part of the 115th-anniversary celebrations of the Brno University of Technology, he was awarded an honorary doctorate on 16 November 2014 based on a proposal by FEEC BUT.<h3>Founder of electron microscopy in Czechoslovakia</h3>In 1951, together with classmates Vladimír Drahoš and Ladislav Zobač, Armin Delong built the first Czechoslovak tabletop electron microscope BS 242, which won a gold medal at the World Exhibition EXPO in Brussels in 1958. Subsequently, they joined the newly-established Institute of Instrumentation Technology of the&nbsp;Czechoslovak Academy of Sciences&nbsp;in Brno. TESLA made electron microscope manufacturing one of its key activities, becoming a global leader in the field for two decades thanks to Delong's ideas.Delong’s legacy lives on in Brno’s top firms and institutions specializing in electron microscopy – such as Delong Instruments, where the professor continued to work even in advanced age. “If you train good students, you might hope they’ll keep you close to the field even after retirement. I managed to achieve this,” Delong recalled in 2015.&nbsp;Other companies that carry his work forward include&nbsp;<a target="_blank" rel="noopener noreferrer" href="https://www.tescan.cz/">TESCAN</a>, <a target="_blank" rel="noopener noreferrer" href="https://www.nenovision.com/">NenoVision</a>, and <a target="_blank" rel="noopener noreferrer" href="https://thermofisher.jobs.cz/">Thermo Fisher Scientific</a>, which is among BUT's key partners. Its technological center in Brno produces cutting-edge electron microscopes and spectrometers used worldwide.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/VUT_v_Brne_archiv_Ladislava_Zobace_Ladislav_Zobac_Armin_Delong_Miroslav_Anderle_a_Vladimir_Drahos_TESLA_BS_242_af46684cd7.jpg" alt="VUT v Brně/Ladislav Zobač's archive: Ladislav Zobač, Armin Delong, Miroslav Anderle, and Vladimír Drahoš; TESLA BS 242." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_VUT_v_Brne_archiv_Ladislava_Zobace_Ladislav_Zobac_Armin_Delong_Miroslav_Anderle_a_Vladimir_Drahos_TESLA_BS_242_af46684cd7.jpg 235w," sizes="100vw" width="1600" height="1066"><h3>Electron microscopy at BUT</h3>Czechoslovak electron microscopy would not have been possible without the support of universities, and Armin Delong’s legacy naturally continues at Brno University of Technology. “Technological and scientific progress happens at universities and technical schools. If it doesn’t, that’s a problem,” Delong emphasized in a 2013 interview.BUT considers electron microscopy as its strategic focus. The university is an integral part of the Brno innovation ecosystem #brnoregion and collaborates long-term with local institutions and companies in developing electron microscopes, new methods, and their applications. “Microscopes serve various purposes – from studying structure, size, topography, and morphology to analyzing defects, fracture surfaces, and quality control of produced micro and nanostructures,” says Petr Lepcio from CEITEC BUT, where electron microscopes are used in nearly every research project. CEITEC Nano houses seven microscopes, which are <a target="_blank" rel="noopener noreferrer" href="https://www.zvut.cz/en/topic/topic-f38144/in-the-footsteps-of-the-invisible-or-electron-microscopy-in-brno-d256161">among the most popular instruments</a> in its labs.Electron microscopy is also intensively studied by scientists at the Faculty of Mechanical Engineering (FME BUT), where it is pursued by the <a target="_blank" rel="noopener noreferrer" href="https://www.fme.vutbr.cz/en/fakulta/struktura/pracoviste/ufi">Institute of Physical Engineering</a>, which is closely linked to CEITEC BUT. Through programs such as Physical Engineering and Nanotechnology or Precision Mechanics and Optics, the faculty educates top experts, many of whom find employment in the aforementioned companies after graduation. The laboratories of the <a target="_blank" rel="noopener noreferrer" href="https://www.fme.vutbr.cz/en/fakulta/struktura/pracoviste/umvi">Institute of Materials Science and Engineering</a> at FME BUT have also since 1974 owned historical transmission electron microscope BS 540, still used for teaching purposes. This microscope was developed with contributions from Tesla Brno, VUT, and CAS, as well as Armin Delong. It was the best microscope manufactured in the CSSR at the time. “Research using this instrument resulted in several patents and countless final theses, probably hundreds. It was also crucial for industrial practice, providing measurements for many factories,” describes Tomáš Podrábský from FME BUT.The field is also represented at Delong’s alma mater, FEEC BUT. The Department&nbsp;of Physics hosts the Laboratory of Electron Microscopy, conducting <a target="_blank" rel="noopener noreferrer" href="https://www.ufyz.fekt.vut.cz/en">microscopic surface and material inspections</a>.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/VUT_v_Brne_Jan_Prokopius_Transmisni_elektronovy_mikroskop_Tesla_BS_540_na_FSI_VUT_bea5bf2aa3.jpg" alt="BUT Brno/Jan Prokopius: Transmission electron microscope Tesla BS 540 at FME BUT. " srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_VUT_v_Brne_Jan_Prokopius_Transmisni_elektronovy_mikroskop_Tesla_BS_540_na_FSI_VUT_bea5bf2aa3.jpg 235w," sizes="100vw" width="800" height="533"><h3>Popularization of electron microscopy</h3>BUT significantly contributes to organizing the Days of Electron Microscopy (DEM), aimed at popularizing the topic among families, schools, and professionals since 2017. <a target="_blank" rel="noopener noreferrer" href="https://www.hvezdarna.cz/en/">Brno Observatory and Planetarium</a>&nbsp;has been the main organiser recently&nbsp;in partnership with companies, universities, and other institutions, offering access to usually restricted labs. Last year’s event focused on microscopic villains, with BUT representatives offering lectures, workshops, lab tours, and an exhibition of oversized viruses. This year’s DEM will occur&nbsp;on 24–30&nbsp;March 2025, with the theme “Villain or Hero”, symbolized by a giant inflatable bacteriophage. BUT is regularly represented at DEM by experts from FME BUT and CEITEC BUT. At CEITEC BUT, Stanislav Průša, also active at FME BUT, promotes (not only) electron microscopy, organizes VUT Junior, CEITEC Summer School, and <a target="_blank" rel="noopener noreferrer" href="https://nano.ceitec.cz/">CEITEC Nano</a> lab tours. “The number of students interested in science and technology has stagnated or even declined. Reversing this trend is a societal priority. Engaging high school students and teachers is essential, but research shows that introducing fields like electron microscopy to elementary students and their parents is equally important, as younger students are often more receptive,” says Průša.<a target="_blank" rel="noopener noreferrer" href="https://www.tmbrno.cz/">Technical Museum in Brno</a> will celebrate the anniversary with a gathering of Armin Delong’s family, colleagues, students, and successors, with events throughout the year. Visitors can also explore the <a target="_blank" rel="noopener noreferrer" href="https://www.tmbrno.cz/expozice/optika/">Optics exhibit</a>, which showcases the history of microscopes, including the rare BS 242 tabletop electron microscope.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/VUT_v_Brne_CEITEC_VUT_Nejen_elektronovou_mikroskopii_popularizuje_na_CEITEC_VUT_Stanislav_Prusa_df1d891ba0.jpeg" alt="VUT v Brně/CEITEC BUT: (Not only) electron microscopy is popularized at CEITEC BUT by Stanislav Průša. " srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_VUT_v_Brne_CEITEC_VUT_Nejen_elektronovou_mikroskopii_popularizuje_na_CEITEC_VUT_Stanislav_Prusa_df1d891ba0.jpeg 235w," sizes="100vw" width="1600" height="1066">Armin Delong’s legacy remains alive at BUT and in Brno, now a global hub for the development and production of electron microscopes used at institutions like NASA and Harvard University. Delong’s words from 2013, “Every professor must identify talented individuals, ensure they don’t leave unnoticed, and work with them to pass on knowledge and ideas to foster growth,” continue to inspire professors and students, enhancing the prestige of Brno’s companies and advancing the entire field.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/VUT_v_Brne_CEITEC_VUT_Frozen_pod_sklickem_elektronoveho_mikroskopu_80bf5f6585.jpg" alt="BUT Brno/CEITEC BUT: &quot;Frozen&quot; under the electron microscope slide." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_VUT_v_Brne_CEITEC_VUT_Frozen_pod_sklickem_elektronoveho_mikroskopu_80bf5f6585.jpg 235w," sizes="100vw" width="1600" height="1065"><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/VUT_v_Brne_Archiv_VUT_Armin_Delong_pri_prebirani_cestneho_doktoratu_na_VUT_2014_83a1c6e3ec.jpg" alt="BUT Brno/Archive BUT: Armin Delong receiving an honorary doctorate at BUT, 2014. " srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_VUT_v_Brne_Archiv_VUT_Armin_Delong_pri_prebirani_cestneho_doktoratu_na_VUT_2014_83a1c6e3ec.jpg 235w," sizes="100vw" width="1600" height="1066"><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/VUT_v_Brne_CEITEC_VUT_Dny_elektronove_mikroskopie_na_CEITEC_VUT_2_52ced0704a.jpeg" alt="BUT Brno/CEITEC BUT: Electron Microscopy Days at CEITEC BUT." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_VUT_v_Brne_CEITEC_VUT_Dny_elektronove_mikroskopie_na_CEITEC_VUT_2_52ced0704a.jpeg 235w," sizes="100vw" width="1600" height="1067">

100 years since the birth of the father of Czechoslovak electron microscopy

On 14–15 April 2025, the Faculty of Pharmacy of Charles University in Hradec Králové hosted the First Annual International Conference of the project New Technologies for Translational Research in Pharmaceutical Sciences (NETPHARM), co-funded by the Jan Amos Komenský Operational Programme (OP JAK). The project aims to bridge cutting-edge pharmaceutical research with clinical practice and the application sphere, advancing the development of new therapeutic approaches, (nano)formulations, and advanced drug delivery systems.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/FF_UK_Uspesne_setkani_spickovych_vedcu_Prvni_vyrocni_mezinarodni_konference_projektu_NETPHARM_3_b6c493b2d0.jpg" alt="FF UK/Ing. Jan Škop/Mgr. Martina Kopecká Jurčeková: Successful Gathering of Leading Scientists: The First Annual International NETPHARM Conference" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_FF_UK_Uspesne_setkani_spickovych_vedcu_Prvni_vyrocni_mezinarodni_konference_projektu_NETPHARM_3_b6c493b2d0.jpg 208w," sizes="100vw" width="1200" height="900">The conference was opened with an introductory speech by the Dean of the Faculty of Pharmacy of Charles University, Assoc. Prof. Jaroslav Roh, followed by an overview of the NETPHARM project, which was presented by the research project manager Prof. Petr Pávek.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/FF_UK_Successful_Gathering_of_Leading_Scientists_The_First_Annual_International_NETPHARM_Conference_298129dde1.jpg" alt="FF UK/Ing. Jan Škop/Mgr. Martina Kopecká Jurčeková: Successful Gathering of Leading Scientists: The First Annual International NETPHARM Conference (Assoc. Prof. Jaroslav Roh)" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_FF_UK_Successful_Gathering_of_Leading_Scientists_The_First_Annual_International_NETPHARM_Conference_298129dde1.jpg 208w," sizes="100vw" width="1200" height="900">On 16 April 2025, the second International Scientific Advisory Board (ISAB) meeting was held after the conference, which provided valuable recommendations for further development of the project based on the presentations delivered.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/FF_UK_Uspesne_setkani_spickovych_vedcu_Prvni_vyrocni_mezinarodni_konference_projektu_NETPHARM_5_65b5668094.jpg" alt="FF UK/Ing. Jan Škop/Mgr. Martina Kopecká Jurčeková: Successful Gathering of Leading Scientists: The First Annual International NETPHARM Conference" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_FF_UK_Uspesne_setkani_spickovych_vedcu_Prvni_vyrocni_mezinarodni_konference_projektu_NETPHARM_5_65b5668094.jpg 208w," sizes="100vw" width="1200" height="900">In his closing remarks, Professor Petr Pávek expressed his gratitude to all attendees for their active participation and extended his appreciation for the insightful guidance provided by the ISAB.Both the conference and the ISAB meeting received overwhelmingly positive evaluations in terms of scientific content as well as organizational and technical aspects. Participants appreciated the high level of presentations, the welcoming and friendly atmosphere, and the professional background of the entire event.The First Annual Conference of the NETPHARM project clearly demonstrated the tremendous potential of international collaboration in advancing scientific excellence and education. The NETPHARM project is already delivering significant scientific results, fostering personal connections, and strengthening international partnerships.The organizing team and all involved extend their sincere thanks to the project partners, ISAB members, and young promising researchers for their commitment, enthusiasm, and outstanding contributions.We wish everyone continued success in achieving the next project milestones and look forward to future NETPHARM events!<blockquote>For more information about the project, please visit:<a target="_blank" rel="noopener noreferrer" href="https://www.faf.cuni.cz/NETPHARM/?lang=cs-cz">NETPHARM | Farmaceutická fakulta Univerzity Karlovy</a><a target="_blank" rel="noopener noreferrer" href="https://portal.faf.cuni.cz/Projects/NETPHARM-project/">NETPHARM project | Vědecký portál - Farmaceutická fakulta UK</a><a target="_blank" rel="noopener noreferrer" href="https://www.faf.cuni.cz/NETPHARM-Conference/Programme/">Programme | Charles University, Faculty of Pharmacy</a></blockquote>

Successful Gathering of Leading Scientists: The First Annual International NETPHARM Conference

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The Faculty of Pharmacy, with its seat in the town of Hradec Králové, was established by a government decree in 1969. This Faculty of Pharmacy has continued in the old and long-time tradition of the education of pharmacy at Charles University.

Faculty of Pharmacy, Charles University

RECETOX (Research Centre for Toxic Compounds in the Environment) is an independent department of the Faculty of Science of Masaryk University in Brno, which has been established in 1983. RECETOX is focused on the research and education in cross-cutting area of Environment and Health. It addresses interactions among chemicals, environment, and biological systems, including consequences at local, regional, and global levels.

RECETOX - Centrum pro výzkum toxických látek v prostředí

Vysoké učení technické (VUT) v Brně je česká vysoká škola s více než 120letou tradicí. Nabízí studium na osmi fakultách téměř 19 tisícům posluchačů. Dlouhodobě se umísťuje v žebříčku nejlepších světových univerzit QS Top Universities.

Brno University of Technology

The Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences (IOCB Prague) is a leading scientific institution in the Czech Republic, recognized internationally. Its primary mission is basic research in the fields of chemical biology and medicinal chemistry, organic and material oriented chemistry, chemistry of natural compounds, biochemistry and molecular biology, physical chemistry, theoretical chemistry, and analytical chemistry. 

Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences

Masarykova univerzita je vysokou školou s demokratickými tradicemi, prosazovanými již od jejího založení v roce 1919. Řadu let je nejžádanější vysokou školou v Česku. V současnosti sestává z devíti fakult s více než 200 katedrami, ústavy a klinikami. Je také významným sociálním a kulturním aktérem v jihomoravském regionu.

Masarykova univerzita

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