Scientists at IOCB Prague are uncovering new details of gene transcription. They have identified a previously unknown molecular mechanism by which the transcription of genetic information from deoxyribonucleic acid (DNA) into ribonucleic acid (RNA) can be initiated. The researchers focused on a specific class of molecules known as alarmones, which are found in cells across a wide range of organisms and whose levels often increase under conditions of cellular stress. The results were published in the prestigious scientific journal Nature Chemical Biology.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/UOCHB_Vyzkum_z_UOCHB_odhaluje_dosud_nepoznany_zpusob_prepisu_geneticke_informace_bc2bfffa6c.jpg" alt="IOCB Prague/Tomáš Belloň: Research from IOCB Prague reveals a previously unknown mechanism of genetic transcription: Dr. Hana Cahová, head of the Chemical Biology of Nucleic Acids research group." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_UOCHB_Vyzkum_z_UOCHB_odhaluje_dosud_nepoznany_zpusob_prepisu_geneticke_informace_bc2bfffa6c.jpg 234w," sizes="100vw" width="2000" height="1335"><div>Molecules of ribonucleic acid can carry a variety of chemical modifications at one end, known as caps. In eukaryotic organisms, including human cells, the best-known cap plays an important role in RNA stability and in regulating its subsequent fate. In recent years, however, it has become clear that alternative, non-canonical RNA caps also exist, although their formation and the mechanisms by which they are attached to RNA remain only partially understood. These include alarmone caps, formed by dinucleoside polyphosphate molecules, that protect cellular RNA at moments when the cell is under threat.In their study, <a target="_blank" rel="noopener noreferrer" href="https://cahova.group.uochb.cz/en">Dr. Hana Cahová</a> and colleagues examined bacterial RNA polymerase and investigated how this enzyme can initiate transcription using dinucleoside polyphosphates (NpNs) instead of the standard RNA building blocks. For the first time, the scientists described, at the atomic level, how RNA bearing an alarmone cap can be generated directly at the initiation of gene transcription. They also observed that NpNs bind through a different type of base pairing than is typically observed.The work was significantly shaped by Valentina Serianni from Hana Cahová’s team, who demonstrated the ability of dinucleoside polyphosphates to initiate gene transcription, and by Jana Škerlová, who focused on the structural analysis of RNA polymerase. Using cryogenic electron microscopy data, she showed how dinucleoside polyphosphate molecules bind within the active site of RNA polymerase – that is, the core of the enzyme where genetic information is transcribed. Together, their findings help to elucidate the processes that accompany the transcription of genetic information from DNA to RNA.Hana Cahová adds: “We’re describing something that truly occurs in cells and that we’re now able to observe directly at the level of individual molecules. This allows us to answer fundamental questions about cellular processes, such as how cells adapt to stress. RNA plays a central role in this, as it carries the cascade of information underlying any cellular response – for example, to threatening conditions caused by nutrient deprivation or temperature shock.”<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/UOCHB_Vyzkum_z_UOCHB_odhaluje_dosud_nepoznany_zpusob_prepisu_geneticke_informace_2_0fe88ff9e9.jpg" alt="IOCB Prague/Tomáš Belloň: Research from IOCB Prague reveals a previously unknown mechanism of genetic transcription: Dr. Tomáš Kouba, head of the Cryogenic Electron Microscopy core facility." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_UOCHB_Vyzkum_z_UOCHB_odhaluje_dosud_nepoznany_zpusob_prepisu_geneticke_informace_2_0fe88ff9e9.jpg 234w," sizes="100vw" width="2000" height="1335"><div>Cryogenic electron microscopy (cryo-EM) was central to the project. This part of the work was led by Dr. Tomáš Kouba, one of the authors of the study. “Cryogenic electron microscopy allows us to freeze biological molecules in a state very close to their natural form and then determine their three-dimensional structure. This makes it possible to look directly into the active centers of enzymes and observe their function down to the atomic level,” he explains.Last year, IOCB Prague opened a new <a target="_blank" rel="noopener noreferrer" href="https://cryoem.group.uochb.cz/en">cryo-EM center</a> that is unique within the Czech research environment. State-of-the-art cryogenic electron microscopes are housed in a specially designed building and enable the study of biological processes with exceptional structural precision.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/UOCHB_Vyzkum_z_UOCHB_odhaluje_dosud_nepoznany_zpusob_prepisu_geneticke_informace_3_4d881e7a58.jpg" alt="IOCB Prague: Research from IOCB Prague reveals a previously unknown mechanism of genetic transcription: This work shows how NpnNs initiate bacterial transcription. Cryo-EM reveals how nucleobases pair with the template: one in canonical and one in reverse Watson–Crick mode, providing a structural basis for their function as non-canonical RNA caps." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_UOCHB_Vyzkum_z_UOCHB_odhaluje_dosud_nepoznany_zpusob_prepisu_geneticke_informace_3_4d881e7a58.jpg 245w," sizes="100vw" width="2000" height="1077"><blockquote><h4>The Original article</h4><h4><a target="_blank" rel="noopener noreferrer" href="https://www.nature.com/articles/s41589-025-02134-5">Molecular insight into 5′ RNA capping with NpnNs by bacterial RNA polymerase</a></h4>Valentina M. Serianni, Jana Škerlová, Anna Knopp Dubánková, Anton Škríba, Hana Šváchová, Tereza Vučková, Anatolij Filimoněnko, Milan Fábry, Pavlína Řezáčová, Tomáš Kouba &amp; Hana Cahova&nbsp;Nat. Chem. Biol. 21 (2026)<a target="_blank" rel="noopener noreferrer" href="https://doi.org/10.1038/s41589-025-02134-5">https://doi.org/10.1038/s41589-025-02134-5</a><h6>licensed under <a target="_blank" rel="noopener noreferrer" href="https://creativecommons.org/licenses/by/4.0/">CC-BY 4.0</a></h6></blockquote><h4>Abstract</h4>RNA capped with dinucleoside polyphosphates has been discovered in bacteria and eukaryotes only recently. The likely mechanism of this specific capping involves direct incorporation of dinucleoside polyphosphates by RNA polymerase as noncanonical initiating nucleotides. However, how these compounds bind into the active site of RNA polymerase during transcription initiation is unknown. Here, we explored transcription initiation in vitro, using a series of DNA templates in combination with dinucleoside polyphosphates and model RNA polymerase from Thermus thermophilus. We observed that the transcription start site can vary on the basis of the compatibility of the specific template and dinucleoside polyphosphate. Cryo-electron microscopy structures of transcription initiation complexes with dinucleoside polyphosphates revealed that both nucleobase moieties can pair with the DNA template. The first encoded nucleotide pairs in a canonical Watson–Crick manner, whereas the second nucleobase pairs noncanonically in a reverse Watson–Crick manner. Our work provides a structural explanation of how dinucleoside polyphosphates initiate RNA transcription.</div></div>

Research from IOCB Prague reveals a previously unknown mechanism of genetic transcription

In the week from February 9, the following webinars await you in the field of atomic and molecular spectroscopy and spectrometry<blockquote><h4><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/webinars">👉 DETAILS AND REGISTRATION IN THE WEBINARS SECTION</a></h4>👉 Search and filter in the largest global database with over 5 000 GC, LC, MS and spectroscopy webinars.</blockquote><h5>1. Thermo Fisher Scientific: Process Raman – A Reliable and Versatile Tool for Downstream Process Monitoring and Control for mAb Production</h5><ul><li>Tu, 10.2.2026 16:00 CET</li><li><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/webinar/5808">Registration</a></li></ul>The presentation highlights how process Raman spectroscopy offers several advantages over traditional in-line UV-Vis analysis for process monitoring and metabolite production control.<h5>2. Bruker: Meet Compact-Q DEER Spectrometer – Your Gateway to Quantum Innovation</h5><ul><li>Tu, 10.2.2026 17:00 CET</li><li><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/webinar/5757">Registration</a></li></ul>Discover how the Compact-Q DEER spectrometer enables high-fidelity qubit characterization and control, combining advanced microwave architecture, AWGs, and cryogen-free operation.<h5>3. Agilent Technologies: Novel Advancements in Trace Level Determination and Long-Term Stability of Metals in TMAH and UPW Matrices</h5><ul><li>Tu, 10.2.2026 21:30 CET</li><li><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/webinar/3733">Registration</a></li></ul>Explore novel approaches for trace-level metal determination and long-term stability assessment in TMAH and ultrapure water matrices.<h5>4. AZoM: From First to Best – Introducing the Litesizer DIF Series</h5><ul><li>We, 11.2.2026 15:00 CET</li><li><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/webinar/5765">Registration</a></li></ul>Join this live webinar introducing the new Litesizer DIF series of laser diffraction particle size analyzers.<h5>5. Anton Paar: Polymer Rheology – Rotational and Transient Measurements on a Polymer Melt</h5><ul><li>We, 11.2.2026 18:00 CET</li><li><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/webinar/5786">Registration</a></li></ul>Learn how rotational and transient viscosity measurements on rotational rheometers reveal polymer melt flow behavior, from method setup and accessories to data interpretation.<h5>6. Milestone: Practical Guidance to Improve the Journey from Sample to Heavy Metals Analysis for Environmental Labs</h5><ul><li>Th, 12.2.2026 16:00 CET</li><li><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/webinar/5803">Registration</a></li></ul>Improve heavy metals analysis in environmental laboratories with practical tips on reagents, filtration, cleaning, and workflow optimization to enhance data quality and efficiency.<h5>7. Agilent Technologies: Moving from R&amp;D and Limited QC on a UV-Vis-NIR Instrument to Large-Scale QC Using an Autosampler</h5><ul><li>Th, 12.2.2026 20:00 CET</li><li><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/webinar/2104">Registration</a></li></ul>This presentation covers key aspects of adding and using an autosampler to maximize UV-Vis-NIR QC workflows when scaling from R&amp;D to routine quality control.

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LA-ICP-MS imaging, particularly in TOF mode, provides rapid, high-resolution elemental maps of complex geological materials, but quantitative accuracy is often limited by heterogeneous mineralogy. This study introduces a workflow using UMAP for unsupervised dimensionality reduction combined with k-means clustering to segment mineral phases directly from per-pixel elemental data.Cluster compositions are matched to known minerals based on stoichiometry, allowing phase-specific normalization and reducing quantification errors by up to 60%. Validated on dawsonite-bearing sandstones, the approach enables consistent phase-resolved geochemical comparisons across depth profiles and establishes UMAP as a practical tool for accurate, interpretable multielement imaging.<blockquote><h4>The original article</h4><h4><a target="_blank" rel="noopener noreferrer" href="https://pubs.acs.org/doi/10.1021/acs.analchem.5c05398">Mineral Phase-Resolved Quantification in LA-ICP-MS Imaging</a></h4>Barbara Umfahrer, Jakub Buday, Pavel Pořízka, Jozef Kaiser, Paolo S. Garofalo*, and Detlef Günther*Anal. Chem. 2026, 98, 1, 581–589<a target="_blank" rel="noopener noreferrer" href="https://doi.org/10.1021/acs.analchem.5c05398">https://doi.org/10.1021/acs.analchem.5c05398</a><h6>licensed under <a target="_blank" rel="noopener noreferrer" href="https://creativecommons.org/licenses/by/4.0/">CC-BY 4.0</a></h6></blockquote>Selected sections from the article follow. Formats and hyperlinks were adapted from the original.Since its introduction in 1985, <a href="javascript:void(0);">(1)</a> Laser Ablation-Inductively Coupled Plasma-Mass Spectrometry (LA-ICP-MS) has matured into a routine technique for both qualitative and quantitative elemental analysis, finding use in diverse fields such as geology, <a href="javascript:void(0);">(2−4)</a> biology, <a href="javascript:void(0);">(5,6)</a> materials science, <a href="javascript:void(0);">(7)</a> and cultural heritage. <a href="javascript:void(0);">(8,9)</a> Especially in comparison to liquid analysis techniques, the method excels through minimal sample preparation, negligible sample destruction, and low limits of detection, which enable trace element analysis. However, besides the availability of standard reference materials, a longstanding challenge of quantitative LA-ICP-MS is the need for a suitable internal standard to account for variations in ablation rate and transport efficiency, as well as instrumental drift. <a href="javascript:void(0);">(10)</a> Developed for applications in geological matrices, this requirement was elegantly circumvented by Liu et al. <a href="javascript:void(0);">(11)</a> through 100 wt % normalization, which assumes that all detected elements form oxides summing up to 100 wt %. This approach was conceptually inspired by the summed-spectrum normalization calibration procedure introduced by Leach and Hieftje in 2000, which emphasized the use of total signal intensities for robust internal standardization. <a href="javascript:void(0);">(12)</a> The 100 wt % normalization strategy was subsequently extended to the bulk analysis of carbonates. <a href="javascript:void(0);">(13)</a>Concurrently, the advent of time-of-flight (TOF) mass analyzers and the development of fast-washout laser ablation cells <a href="javascript:void(0);">(14−16)</a> have transformed LA-ICP-MS into a powerful imaging tool, capable of generating spatial maps across a variety of sample matrices at high data acquisition rates. <a href="javascript:void(0);">(17−19)</a> Furthermore, in comparison to, e.g., X-ray fluorescence spectroscopy (XRF) or Scanning Electron Microscopy with Energy-Dispersive X-ray Spectroscopy (SEM-EDS), LA-ICP-MS offers a high depth resolution of approximately 0.2 μm on glass, enabling precise measurement of fine-scale structures not only laterally but also in depth. <a href="javascript:void(0);">(18)</a> However, as the volume and complexity of these elemental images have grown according to the progressive advancement of the method itself, now consisting of gigabytes of data produced within minutes, manual data interpretation has become increasingly impractical. To uncover meaningful details and patterns, researchers have applied multivariate methods such as Principal Component Analysis (PCA) and k-means clustering to reduce dimensionality and delineate distinct regions within the images. <a href="javascript:void(0);">(20−23)</a> The nonlinear dimensionality reduction technique Uniform Manifold Approximation and Projection (UMAP), <a href="javascript:void(0);">(24)</a> which supports data interpretation with its capability to capture and separate subtle local structures, has first been employed to LA-ICP-MS bulk analysis data in 2024, where it was used to classify pyrite samples and discriminate between Pb and Zn deposit types. <a href="javascript:void(0);">(25,26)</a> In combination with elemental imaging, UMAP has recently been applied to biological tissue data sets as an exploratory analysis tool, <a href="javascript:void(0);">(27)</a> further enhancing the ability to visualize and interpret complex elemental distributions.Despite these advances, no existing approach combines the unsupervised segmentation of mineral phases by UMAP with phase-specific normalization. In this study, we introduce a UMAP-driven workflow that (1) automatically segments distinct mineralogical phases within fine-grained geological matrices and (2) applies phase-specific 100 wt % normalization (e.g., oxide <a href="javascript:void(0);">(11)</a> or carbonate <a href="javascript:void(0);">(13)</a>), thereby improving quantification accuracy and enabling phase-specific quantitative interpretation of mineral distributions in complex matrices.<h4>Materials and Methods</h4><h5>LA-ICP-TOFMS Imaging</h5>LA-ICP-TOFMS analyses were performed using a 193 nm ArF excimer laser (GeoLas C, Lambda Physik, Göttingen, Germany) coupled to an ICP-TOFMS instrument (icpTOF 2R, TOFWERK AG, Thun, Switzerland). Ablation was conducted in the modified parallel flow ablation cell (MPFAC) <a href="javascript:void(0);">(16,34)</a> under a He atmosphere (99.999%, Linde Gas Schweiz AG, Dagmersellen, Switzerland) with Ar (99.996%, Linde Gas Schweiz AG) used as the carrier gas. A piezoelectrically driven xyz translational stage (1 nm resolution, SmarAct GmbH, Oldenburg, Germany) enabled precise sample positioning. Laser, stage movement, and ICP-TOFMS data acquisition were synchronized using a custom-built imaging control system. <a href="javascript:void(0);">(19)</a> The system was optimized each day based on maximum sensitivity while ensuring a 238U+/232Th+ intensity ratio of 1.0 to 1.1 on NIST SRM 610 and a 232Th16O+/232Th+ rate of below 0.5%.<h5>LIBS Imaging</h5>The LIBS analyses were performed on a Firefly system (Lightigo, Czech Republic). The laser (1064 nm, 5 mJ, pulse duration ∼10 ns, diameter 6 mm, operating at 50 Hz) was focused on the sample with a singlet lens (focal length 50 mm) to a 30 μm spot. The spatial resolution of the acquired elemental maps, with a size of about 16 mm × 26 mm, was 20 μm. Plasma radiation is collected by a multifiber configuration with a collimator and an optical fiber (400 μm core diameter), which delivered the light to several Czerny–Turner spectrometers (resolution 0.25–0.4 nm). The spectral range of the spectrometers is 180–850 nm. The radiation is collected 1.5 μs after ablation, with a gate width of 15 μs.Data processing was done with Python 3.11.8 in the Spyder environment and included background correction and per-pixel z-score normalization.<h4>Results and Discussion</h4><h5>LIBS and XRD Measurements</h5>To assess whether carbonate-based normalization <a href="javascript:void(0);">(13)</a> is warranted, first, large-scale LIBS elemental intensity maps of the samples across about a third of the thin sections were acquired. <a target="_blank" rel="noopener noreferrer" href="https://pubs.acs.org/doi/10.1021/acs.analchem.5c05398#fig1">Figure 1</a> reveals the results for “Layer 2” of the Poggio del Gatto sandstone for selected elements. A complete mapping of all four thin sections can be found in <a target="_blank" rel="noopener noreferrer" href="https://pubs.acs.org/doi/suppl/10.1021/acs.analchem.5c05398/suppl_file/ac5c05398_si_001.pdf">Figures S3 and S6</a> in the Supporting Information. The maps reveal that C is strongly enriched in fracture veins as well as in finer-grained domains within the matrix and correlates with Ca, indicating carbonate minerals rather than oxides. Bulk XRD analysis identifies calcite alongside quartz, plagioclase, white mica, and kaolinite. These complementary observations confirm calcite as a major phase and thus justify the need for performing the 100 wt % normalization on a carbonate basis for pixels representing calcite.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Anal_Chem_2026_98_1_581_589_Figure_1_LIBS_elemental_intensity_maps_of_the_data_set_from_Layer_2_of_the_Poggio_del_Gatto_sandstone_mounted_on_a_microscope_slide_73ada1b7b8.jpg" alt="Anal. Chem. 2026, 98, 1, 581–589: Figure 1. LIBS elemental intensity maps of the data set from “Layer 2” of the Poggio del Gatto sandstone mounted on a microscope slide, depicting calcite veins and fine-grained structures within the matrix, underlining the need for carbonate-based normalization for specific pixels. Emission lines for evaluation are shown in the corresponding subfigure title. The epoxy used to fix the thin section on the slide is visible along the margin." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Anal_Chem_2026_98_1_581_589_Figure_1_LIBS_elemental_intensity_maps_of_the_data_set_from_Layer_2_of_the_Poggio_del_Gatto_sandstone_mounted_on_a_microscope_slide_73ada1b7b8.jpg 245w," sizes="100vw" width="2088" height="414"><h5>Renormalization Based on Carbonates</h5>Applying an oxide-based normalization to carbonate samples will introduce composition-dependent biases that cannot immediately be generalized as a singular numerical value. The difference between the molecular masses of carbonate CO32– and its oxide equivalent O2– yields an intrinsic bias on the order of a factor of about two, depending on the stoichiometry. Once this data is renormalized to a total of 100 wt %, the magnitude of the error becomes highly dependent on the specific elemental composition of the sample. An exemplary calculation illustrating this effect for a representative calcite pixel is provided in <a target="_blank" rel="noopener noreferrer" href="https://pubs.acs.org/doi/suppl/10.1021/acs.analchem.5c05398/suppl_file/ac5c05398_si_001.pdf">Table S2</a>, yielding a relative error of 79%. In practice, this error varies across the image according to the local phase composition. <a target="_blank" rel="noopener noreferrer" href="https://pubs.acs.org/doi/10.1021/acs.analchem.5c05398#fig6">Figure 6</a> illustrates the impact of normalization approaches for layer 2 of the samples as well as the spatial distribution of the resulting relative error. The figure presents Ca and Si elemental maps in two rows, while the first three columns compare different normalization strategies: normalization based on all oxides, normalization based on all carbonates, and a pixel-wise normalization guided by mineral phase identification, as outlined in the workflow proposed in this study. The final column displays the relative error between the bulk oxide- or carbonate-based normalization and the pixel-wise, phase-informed normalization.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Anal_Chem_2026_98_1_581_589_Figure_6_Comparison_of_normalization_strategies_for_Ca_and_Si_LA_ICP_TOFMS_elemental_maps_in_Layer_2_ce3a0c1a5c.jpg" alt="Anal. Chem. 2026, 98, 1, 581–589: Figure 6. Comparison of normalization strategies for Ca and Si LA-ICP-TOFMS elemental maps in “Layer 2” of the Poggio del Gatto sandstone. Rows show Ca (top) and Si (bottom); columns compare (1) oxide-based normalization, (2) carbonate-based normalization, (3) pixel-wise, phase-informed normalization (this study), and (4) relative error between the first two and the phase-informed approach." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Anal_Chem_2026_98_1_581_589_Figure_6_Comparison_of_normalization_strategies_for_Ca_and_Si_LA_ICP_TOFMS_elemental_maps_in_Layer_2_ce3a0c1a5c.jpg 202w," sizes="100vw" width="2088" height="1622">For Ca (in this matrix primarily associated with calcite, a dominant carbonate phase in our samples), the relative error depicted quantifies the effect of applying oxide-based normalization across the entire image. This results in a systematic overestimation of the Ca concentration by approximately 60%. Conversely, for Si─in this matrix found mainly in quartz and various plagioclase phases─the error is shown for applying carbonate-based normalization across an oxidic matrix. In such cases, the Si concentrations are underestimated by roughly 10% to 40%, depending on the mineral phase.These findings highlight that using a single normalization scheme across heterogeneous samples introduces substantial quantification errors. To mitigate this, the pixel-wise phase segmentation enabled by the proposed UMAP-based workflow offers a significant advantage, especially in fine-grained matrices. In short, phase-aware, pixel-wise normalization combines the strengths of both normalization approaches and proves to be highly beneficial.<h4>Conclusion</h4>This study demonstrates that phase-specific normalization, guided by unsupervised phase segmentation of LA-ICP-MS images, can substantially improve the accuracy of elemental quantification in fine-grained geological matrices. Rather than relying on a single global assumption (e.g., all oxides or all carbonates), the workflow adapts normalization to the actual mineralogy, minimizing systematic errors and enabling phase-resolved geochemical interpretation.The segmentation step, based on UMAP embedding and k-means clustering, is fully unsupervised. However, the subsequent matching of clusters to specific minerals still relies on a limited set of preidentified stoichiometries and is therefore not yet fully unsupervised. Expansion to larger stoichiometric databases could help overcome this limitation and move toward automated mineral classification. A key challenge remains the similarity of cation ratios in certain mineral groups, which may still require complementary data to ensure robust assignments.Overall, beyond the specific case of the Poggio del Gatto sandstone presented in this study, this work provides a framework for quantitative elemental imaging of complex geological samples and is readily transferable to other contexts that require spatially resolved composition-aware normalization. This contribution adds a practical implementation to a growing literature that already uses multivariate statistics to unlock the immense information depth of LA-ICP-TOFMS.

Mineral Phase-Resolved Quantification in LA-ICP-MS Imaging

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The Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences (IOCB Prague) is a leading scientific institution in the Czech Republic, recognized internationally. Its primary mission is basic research in the fields of chemical biology and medicinal chemistry, organic and material oriented chemistry, chemistry of natural compounds, biochemistry and molecular biology, physical chemistry, theoretical chemistry, and analytical chemistry. 

Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences

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Extractables and leachables (E&amp;Ls) analysis is challenging and requires complete confidence in the results to ensure regulatory compliance. No single analytical tool can analyze all E&Ls; we offer diverse analytical technologies and expertise for the accurate identification and quantification of potential E&amp;Ls.
In this webinar our experts will discuss current regulatory updates, holistic and comprehensive analytical workflow strategies for quick scouting, profiling &amp; quantification of wide spectrum E&amp;L impurities and answer any questions you may have.
<h3>You would learn:</h3>
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<li>Regulatory updates on Extractables &amp; Leachables;</li>
<li>Overall comprehensive approach &amp; strategies to screen, detect, identify &amp; quantify Extractable &amp; Leachable compounds in various Pharma &amp; Biopharmaceutical drugs;</li>
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Presenter: Antonio Chana (Product Specialist Liquid Phase Separation, Agilent Technologies)
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Antonio Chana, Ph. D. in chemistry and Agilent product specialist in liquid phase separation for Spain and Portugal. He joined Agilent from the pharmaceutical industry where he has held positions of analytical development manager, QC manager and laboratory manager among others.
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Presenter: Zainul Abid CKV (Product Specialist - Spectroscopy, Agilent Technologies)
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Dr Zainul Abid is a product specialist with Agilent Technologies India Pvt Ltd based in Bangalore. He has several years of research and application development experience in Molecular spectroscopy domain. His expertise includes infrared spectroscopy and imaging, Raman spectroscopy and imaging, UV-Vis and NIR spectroscopy etc. He actively works with different industry experts to set up high-end spectroscopy laboratories.
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Presenter: Soma Dasgupta (PhD Application Engineer, GC/GCMS, Agilent Technologies)
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Soma received her PhD from the University of Pune, India and joined Agilent in 2016 and specializes in areas including multi-residue method development; pesticides and environmental applications and genotoxic impurities in pharmaceuticals. Prior to joining Agilent Technologies, she performed her doctorate research at the University of Pune in conjunction with the National Research Centre for Grapes where she concentrated on developing comprehensive methods for analysis of agro-chemicals in fruits and vegetables. She has worked with Thermo Fisher Scientific as Application Specialist for GC and GC-MS. Once joining Agilent, she is responsible for solutions meet our customers&#39; analytical needs. Her specialties include multi-residue method development; pesticides and environmental applications and genotoxic impurities in pharmaceuticals. She has more than 25 publications in peer-reviewed journals and application notes to her credit and a book chapter as well.
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Presenter: Prasanth Joseph (Presales Application Engineer- LCMS, Agilent Technologies)
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Prasanth Joseph is working as Application Engineer at Agilent Center of Excellence, Bangalore. He is having more than 16 years of experience in handling LC-MS/MS for various small molecule applications.His expertise includes MRM based screening and quantitation of various chemical residues in food commodities and pharma applications such as impurity profiling, genotoxic impurity quantitation and analysis of extractables and leachables in various packaging systems.
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Presenter: Vinay Jain (COE Manager, Agilent Technologies)
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<blockquote>
Dr Vinay Jain, working as COE Manager and ICP-MS Application Scientist at Agilent Technologies India. He is Ph.D. on analytical chemistry. He has more than 30 years of analytical and research experience in spectroscopic techniques (LC-ICPMS, GC-ICPMS, ICP-MS QQQ, ICP-MS, ICP-OES, AAS, XRF, XRD) and expertise in various market segments such as Pharma, Food &amp; Farm products, Packaging, Chemical, Clinical, Environment, Petroleum, Ayurveda &amp; Herbal. His area of specialization includes new analytical method development and validation as per regulatory guidelines. He has completed more than 28 research projects with various research and regulatory organizations, of national and international importance. He is having two patents, six research paper publication; two chapters in various international handbooks and five Agilent application notes in his credit. Received TechInnovation Award in 2020 from Agilent Technologies India.
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Agilent Technologies: Mitigating the Risk of Extractables & Leachables Analysis - Regulatory Updates & Analytical Workflow Strategies

Mitigating the Risk of Extractables & Leachables Analysis - Regulatory Updates & Analytical Workflow Strategies

This month-long, five-parts Energy and Chemical application workshop will showcase all Agilent atomic spectroscopy techniques, including ICP-OES and ICP-MS, and MPAES.
Week 1: We will start this series with our experts discussing sample preparation and sample introduction.
Week 2: We first give an overview of all the ASTM methods our atomic spectroscopy applications support, followed by breakout sessions with our experts of each technique for more detailed discussions. Bring your questions and comments to this small group, technique specific discussions.
Week 3: We will focus on applications (besides the ASTM methods discussed last week), both common and unique. We will continue to have breakout sessions for each technique with smaller group size and more detailed discussion for these applications. We look forward to all your comments and questions.
Week 4: We will have a live demo in one of our Center of Excellence (COE) to show you the features in both software and hardware of our ICP-OES and MPAES. We will have real world samples for the analysis and showcase the exceptional results our systems can provide.
Week 5: The workshop&#39;s final week, we will continue the live demo with features in software and hardware of our ICPMS systems, both single quadrupole, and triple quadrupole. We will show the robustness of the systems for all sample types while maintaining ultralow level analyte determination. We will also highlight the ability of the triple quadrupole system to remove interference for certain difficult analytes. In these two weeks&#39; live events, we look forward to interacting with the audience to answer any questions regarding the application or our systems.
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Presenter: Jenny Nelson, PhD (Application Scientist, Agilent Technologies, Inc.)
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Jenny Nelson received her Ph.D. in Analytical Chemistry from the University of Cincinnati in 2007, and her MBA from Saint Mary’s College of California in 2011. Currently, Jenny is an Application Scientist for the Life Science and Chemical Analysis team at Agilent Technologies, joining in 2012 (with a step away in 2019). Jenny is also an Adjunct Professor in the Department of Viticulture and Enology at the University of California, Davis, since 2013. Jenny has been very active with AOAC and ASTM over the past eight years, serving on expert review panels, chairing committees, and volunteering to develop new methods needed by the industry. Jenny has extensive experience in operating and method development for Inductively Coupled Plasma Mass Spectroscopy (ICP-MS), Inductively Coupled Plasma Optical Emission Spectroscopy (ICP-OES), Microwave Plasma Atomic Emission Spectroscopy (MP-AES). Jenny has broad knowledge and experience in different speciation analysis for many sample matrices using GC-ICPMS and LC-ICPMS. As well as vast experience with sp-ICP-MS for many applications.
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Presenter: Yan Cheung (Applications Chemist, Agilent Technologies, Inc.)
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Yan received her Ph.D. in Analytical Chemistry from Indiana University Bloomington. She joined Agilent Technologies as an Application Scientist in the Life Science and Chemical Analysis team in April 2020. Yan has extensive experience in operating and method development in ICP-MS. Yan also has years of experience working in the oil and gas industry.
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Presenter: Paul Krampitz (Application Scientist, Agilent Technologies, Inc.)
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Graduate of Bowling Green State University with a Chemistry Bachelor of Science degree. Twenty – five years of Spectroscopy experience mainly Inductively Coupled Plasma (ICP) Spectroscopy as well as ICP-MS and AAS. Experience also includes X-Ray Fluorescence (ED, WD), Laser Ablation, Inorganic Speciation and Microwave Plasma Spectroscopy. Market Segment expertise includes environmental, petrochemical, metallurgical applications.
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Presenter: Mark Kelinske (Application Scientist, Agilent Technologies, Inc.)
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Mark Kelinske is an Applications Chemist with Agilent Technologies, specializing in advanced ICP-MS and ICP-MS/MS techniques. He received his undergraduate and graduate degrees from Texas A&amp;M University in College Station, TX. Prior to Agilent, Mark was a senior research scientist and research group manager with Southern Research Institute in Birmingham, AL, where he focused on low-level analytical chemistry, method development, and research program management.
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Agilent Technologies: Agilent Atomic Spectroscopy in Energy and Chemicals Part 2: New and Existing ASTM Methods in ICP-OES, MP-AES, and ICP-MS

New and Existing ASTM Methods in ICP-OES, MP-AES, and ICP-MS

ASTM methods our atomic spectroscopy applications support, followed by breakout sessions with our experts of each technique for more detailed discussions.

ASTM Methods in ICP-OES, MP-AES, and ICP-MS

Agilent Technologies: Agilent Atomic Spectroscopy in Energy and Chemicals Part 3: Energy and Chemical Applications in ICP-OES, MP-AES, and ICP-MS

Energy and Chemical Applications in ICP-OES, MP-AES, and ICP-MS

Breakout sessions for each technique with smaller group size and more detailed discussion for these applications.

Energy and Chemical apps in ICP-OES, MP-AES, and ICP-MS

Agilent Technologies: Agilent Atomic Spectroscopy in Energy and Chemicals Part 4: ICP-OES and MP-AES Software and Hardware live demo

ICP-OES and MP-AES Software and Hardware live demo

The features in both software and hardware of our ICP-OES and MPAES.

Agilent Technologies: Agilent Atomic Spectroscopy in Energy and Chemicals Part 5: ICP-MS Software and Hardware live demo

ICP-MS Software and Hardware live demo

Live demo with features in software and hardware of our ICPMS systems, both single quadrupole, and triple quadrupole.

Agilent ICP-MS Software and Hardware live demo

Inductively coupled plasma-mass spectrometry (ICP-MS) is one of the most powerful techniques used in elemental analysis for environmental applications.
It provides the advantages of low detection limits, easy quantification, and high throughput. However, experience and best practice are necessary to best use the technique. This webcast series focuses on both routine regulatory monitoring (Part I) and solutions to improve productivity and overcome the challenges of high-matrix samples (Part II). In addition, we will discuss the use of triple quadrupole ICP-MS to meet the needs of environmental researchers and specialty environmental applications.
The webcast will cover the following:
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<li>Environmental regulations in both the U.S. and Europe
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<li>Tips and tricks on EPA Methods 200.8 and 6020
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<li>Autodilution for productivity improvement for high-matrix samples
</li>
<li>Advanced environmental sample analysis using triple quadrupole ICP-MS
</li>
</ul>
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Presenter: Wei Liu, Ph.D., MBA (Senior Vertical Marketing Manager, Environmental &amp; Industrial Markets, Chromatography &amp; Mass Spectrometry Division, Thermo Fisher Scientific)
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Wei Liu is a Senior Market Development Manager with a focus on trace elemental analysis applications in environmental and industrial markets in the Chromatography and Mass Spectrometry Division at Thermo Fisher Scientific Inc. Earlier in his career, Wei worked as a scientist in the field of industrial enzymes and drug discovery. Since obtaining his MBA from the Haas School of Business at UC Berkeley, he has held a wide range of roles including regional marketing manager, marketing consultant, product manager, and market research manager. Wei earned a Ph.D. in Molecular Microbiology from the University of Illinois at Chicago and completed postdoctoral training at Stanford University. He has 14 international scientific publications and four patents to his credit.
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Presenter: Simon Nelms, Ph.D. (Marketing Manager-Europe, Trace Element Analysis, Chromatography &amp; Mass Spectrometry Division, Thermo Fisher Scientific)
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Simon Nelms is a former ICP-OES and ICP-MS applications specialist who&#39;s been part of the Thermo Fisher Scientific team for almost 20 years. Simon&#39;s trace element instrumentation experience covers the whole range of trace elemental analysis applications, with a particular focus on clinical and pharmaceutical analysis. He is now responsible for marketing AA, ICP-OES, and ICP-MS products in EMEA for the pharmaceutical, environmental, clinical, and food markets. Simon holds a BSc in Analytical Chemistry and a PhD in research involving ICP-MS method development from the University of Hull, UK, and is a member of the Royal Society of Chemistry (MRSC).
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Presenter: David Bowden (Inorganics Manager, Advanced Environmental Laboratory)
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David Bowden is currently the inorganic manager at Advanced Environmental Laboratory in Jacksonville, Florida. He has over 30 years of work experience in analytical laboratories, ranging from environmental to R&amp;D to quality control of semiconductor gases. He has done extensive analytical work using ICP-MS, ICP-AES, FLAA, CVAA, GFAA, HGAA, IC, UV-VIS, as well as numerous wet chemical, gravimetric, optical and thermal techniques. He has worked with a variety of matrices, including water, soil, air, wipes, hazardous waste, pharmaceuticals, food, human tissue, asbestos, and geothermal brine.
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Thermo Scientific: Trace Element Analysis Using ICP-MS for Environmental Samples, Part One: Regulations and Routine Monitoring

Trace Element Analysis Using ICP-MS for Environmental Samples, Part One: Regulations and Routine Monitoring

Routine regulatory monitoring and solutions to improve productivity and overcome the challenges of high-matrix samples.

Trace Element Analysis Using ICP-MS

The rapid growth of the cannabis industry has provided a rare opportunity for scientists to be part of an emerging field. &nbsp;With that expansion, concerns related to the growth, extraction, and chemical analysis of cannabis have also increased. &nbsp;As new jurisdictions allow for cannabis, a disparate and constantly evolving compliance world has been created. &nbsp;Ideas for leveraging the research capabilities of academics to enhance problem solving and workflow optimization when working with the cannabis industry will be presented.Key Learning Objectives:<ul><li>Strategies for building a strong team in a cannabis facility</li><li>Approaches for addressing challenges of cannabis analysis</li><li>Understanding the intersection of product quality and safety</li></ul>Who Should Attend:<ul><li>Future or current cannabis lab managers</li><li>Future or current cannabis testing lab analysts and chemists</li><li>Entrepreneurs considering starting a cannabis testing lab</li></ul>For any questions please contact Jordan Ramesh: <a href="mailto:jramesh@mjhlifesciences.com">jramesh@mjhlifesciences.com</a><blockquote>Presenter: Steven Johnson, Ph.D. (Dean, College of Science and the Environment, Lake Superior State University)Dr. Steven Johnson earned his PhD in chemistry from Michigan Technological University focusing on heterologous expression of proteins. After completing a postdoctoral position working on the use of the botulinum toxin for the delivery of therapeutic cargo to neural cells, he accepted a faculty position at the University of New England. In 2013, Dr. Johnson returned to the Upper Peninsula of Michigan to join the faculty at Lake Superior State University. During his time at LSSU, he has served as co-chair for the School of Physical Science, chair for the School of Science and Medicine, and now, as Dean for the College of Science and the Environment. As Dean, LSSU introduced a bachelor’s degree in Cannabis Chemistry, which prepares graduates for the burgeoning cannabis sector in the State of Michigan and beyond.Presenter:&nbsp;Ryan Ratzloff (CEO/President, Lion Labs)Ryan Ratzloff has been a part of the cannabis industry in Michigan since its early, caregiver-based days. With over 10 years of experience in growing, processing, and marketing cannabis-based products, Ryan and the Lion Labs Ltd organization have established a standard of excellence across several categories with their award-winning and successful brands: Element, Dream, and RISE. Ryan also brings 10+ years of CPG experience from his early career at PepsiCo.Presenter: Anthony Macherone, Ph.D. (Strategic Technical Scientist, Agilent Technologies, Inc.)Dr. Macherone leads a team of scientists for the development and deployment of analytical testing methodologies for cannabis and hemp products. Anthony has written extensively on cannabis testing and contributed several chapters to books about cannabis. In June 2020, Anthony joined Cannabis Science and Technology®’s Editorial Advisory Board.&nbsp;Presenter:&nbsp;Derek Wright, Ph.D. (Associate Professor of Environmental Science, Lake Superior State University)Dr. Derek Wright is an Associate Professor of Environmental Science at Lake Superior State University. Dr. Wright earned his Ph.D. in Environmental Science from Rutgers University in 2008, with an emphasis of the biogeochemical cycles of trace elements in the marine systems. In his more than 20 years of experience with trace element analysis, he has extensive experience in ICP-MS (quadrupole and sector field), ICP-OES, MP-AES, and AAS. He has utilized these techniques for the accurate and precise measurement of challenging sample types such as seawater, hydrothermal vent fluids, atmospheric deposition, biological tissues, soils, foods, and sediments.During his time at LSSU, he has served as chair for the School of Physical Sciences, and taught coursework in Environmental Science, Environmental Chemistry, and Environmental Health. In addition to trace element analysis his research also utilizes microbial source tracking methods.Presenter:&nbsp; Alexander Adams (CEO, Cambium Analytica)Alexander Adams is the Co-Founder and CEO of Cambium Analytica, an analytical laboratory Traverse City, MI that is a full service provider of regulatory compliance testing, product research &amp; development, and quality assurance / quality control services to the cannabis industry. He received a degree in Plant Biology from Michigan State University and has spent the past decade working in many areas of Michigan’s specialty crop agriculture industry.Presenter:&nbsp;Dr. Markus Roggen (President/CSO, Delic Labs)Dr. Markus Roggen is President and Chief Scientific Officer of Delic Labs, a licensed cannabis and psilocybin research laboratory focused on extraction optimization, analytical testing, and process development. Delic Labs is one of a handful of research labs licensed for both cannabis and psilocybin in Canada. Delic Labs was initially founded as Complex Biotech Discovery Ventures by Dr. Roggen and Prof. Dr. Glenn Sammis in 2018, and rebranded after the sale to Delic Corp.Dr. Roggen received his M/Sci degree from Imperial College, London, UK in 2008. He then pursued his graduate degree in organic chemistry at the Federal Institute of Technology in Zürich (ETHZ), where he received his PhD in 2012. Dr. Roggen was awarded an DAAD postdoctoral fellowship to pursue further training in physical organic chemistry at The Scripps Research Institute in La Jolla in 2013-2014. He then entered the cannabis industry in 2014 and since has held executive positions in analytical and production companies. His research into process optimization and analytical methods has been recognized with a number of awards, ElSohley Award of the ACS, Cannabis Scientist Power List 2020 &amp; 2021, 40 under 40 by Marijuana Venture Magazine among others. Dr. Roggen is also a trusted advisor and mentor to multiple startups, startup accelerators and organizations.Presenter:&nbsp;R. Adam Mosey, Ph.D. (Associate Professor of Chemistry, Lake Superior State University)Adam Mosey earned his PhD in Chemistry from Michigan State University and completed a postdoctoral appointment at the University of Pittsburgh before joining Lake Superior State University as an assistant professor in 2012. His research background lies the areas of organic synthesis and drug development. He currently teaches courses in Organic Chemistry, Cannabis Chemistry, and Molecular Spectroscopy, and his current research interests involve reaction development, drug design, NMR method development, and methods of cannabinoid extraction and characterization.Presenter:&nbsp;Jonathan Kane, Ph.D. (Chief Scientific Officer, Lion Labs)Prior to entering the cannabis space, Dr. Kane has a demonstrated history of working in preclinical research with a focus on cancer and stem cell biology and success in biotech sales focusing on preclinical radiation-based research systems. Since leaving the preclinical research space in 2018, Jonathan have taken the role as Co-Founder and Chief Scientific Officer at Lion Labs, a medical and adult-use state licensed cannabis processor located in Michigan. Jonathan received his PhD in Biomedical and Biological Sciences in 2016 from Oakland University.</blockquote>

Agilent Technologies: Agilent Webinars On Demand

Grow Your Skills in the Budding Cannabis Industry 2-Day Symposium (Day 1)

Ideas for leveraging the research capabilities of academics to enhance problem solving and workflow optimization when working with the cannabis industry

Grow Your Skills in the Budding Cannabis Industry (Day 1)

Companies and universities around the world are making all-out efforts to improve the performance of lithium-ion batteries, reduce costs, and develop efficient recycling processes. Meeting these challenges will require an array of instrumentation for analyzing everything from raw materials to individual components of each battery, such as positive and negative electrodes, electrolyte solutions, and black mass for recycling. Because each of these matrices presents unique analytical challenges, specific methodologies are needed to aid R&amp;D, manufacturing, and quality control processes.Join this webinar to learn innovative techniques for overcoming unique matric-specific challenges for analyzing black mass, electrolyte solutions, anode materials, and cathode materials by ICP-AES, TOC, and X-ray fluorescence.Who should attend:<ul><li>Research scientists developing innovative LiB materials and recycling processes</li><li>Engineering professionals working to develop, extract, refine, produce, and process LiB materials</li><li>Mining, production, and recycling operations seeking to expand analytical testing capabilities of LiB materials and black mass</li><li>Quality control analysts working to improve production processes</li><li>Battery industry consultants assisting clients to secure innovative instrumental characterization techniques</li></ul>Attend this webinar and discover innovations in:<ul><li>Simplified quantitative analysis of black mass for LiB recycling using ICP-AES and EDXRF</li><li>Organic carbon analysis of lithium brines and electrode raw materials</li><li>Matrix-specific challenges for ICP-AES analysis of LiB anode, cathode, and electrolyte solution materials, as well as black mass for recycling</li><li>Fast, simple qualitative analysis of LiB black mass and electrolyte solutions using EDXRF</li></ul><blockquote>Presenter: Jon Peters (Moderator) (Senior Market Manager, Chemical and Energy, Shimadzu Scientific Instruments)Jon Peters is Chemical and Energy Market Manager with Shimadzu Scientific Instruments. He applies his experience with spectroscopy, chromatography, software, consumables, and sample introduction instrumentation to create innovative marketing initiatives.Presenter: Dr. Haihan Chen (Product Manager, Elemental Spectroscopy, Shimadzu Scientific Instruments)Haihan Chen is Elemental Spectroscopy Product Manager with Shimadzu Scientific Instruments. She holds a PhD in Chemical Engineering, has published more than 20 peer-reviewed papers, and has more than 15 years of experience with analytical instrumentation including ICP-AES, ICP-MS, AA, TOC, and X-ray fluorescence.Presenter: Dr. Joel Langford (Product Coordinator, Elemental Spectroscopy, Shimadzu Scientific Instruments)Dr. Joel Langford is Product Coordinator for Elemental Spectroscopy with Shimadzu Scientific Instruments. Joel holds a Ph.D. in Chemistry from UC Irvine, having studied condensed materials with X-ray technologies including a Synchrotron, EPMA, WDXRF, EDXRF, and XRD. Since joining Shimadzu in 2018, Joel has specialized in developing innovative X-ray applications.Presenter: Keith Long (Tech Support Lead, Elemental Spectroscopy, Shimadzu Scientific Instruments)Keith Long earned his BSc in Chemistry from Northern Kentucky University and has over 20 years of experience in analytical testing and technologies. He joined the Elemental Spectroscopy group with Shimadzu in 2010, and has become a leading expert in the U.S. for TOC analysis, led by Shimadzu’s flagship TOC-L.</blockquote>

Shimadzu Corporation: Elemental Analysis: Energize the Future with Advanced Battery Testing Solutions

Elemental Analysis: Energize the Future with Advanced Battery Testing Solutions

Innovative techniques for overcoming unique matric-specific challenges for analyzing black mass, electrolyte solutions, anode materials, and cathode materials.

Energize the Future with Advanced Battery Testing Solutions

<h5>By attending this webinar, you will learn about:</h5><ul><li>The most common causes of unplanned downtime and inconsistent results, and what you can do to reduce this unplanned downtime.</li><li>New sample introduction components for ICP-OES that improve analytical performance and reduce blockages when analyzing challenging sample matrices.</li><li>Essential operational tips and guidelines that can help you improve the performance of your ICP-OES when analyzing challenging sample matrices.</li></ul><h5>Event Overview</h5>Improving efficiency in routine analyses in your lab is crucial and should be a priority for any lab. Running challenging sample matrices using the ICP-OES technique poses many challenges for your analysts. They risk unplanned downtime from potential nebulizer or injector blockage, or other sample related issues. This sacrifices your sample throughput as your analysts need to first solve the issues – and then re-run samples where the results have been impacted by the loss of sensitivity from the partial or complete blockage. Challenging sample matrices can also increase your cost of ownership as components that wear need more frequent replacement.In this webinar, we'll provide an overview of some new sample introduction components that remove those pain points around running challenging sample matrices by ICP-OES efficiently. We’ll highlight the unique design features that enhance the total dissolved solid and particle handling capabilities, reducing the risk of nebulizer and injector blockage.We’ll demonstrate the capabilities of this robust sample introduction system with two challenging sample matrices, including used lubricating oils, where carbon build-up and larger wear metal particles can create a blockage risk. The second matrix is “black mass” – the material created when lithium-ion batteries are shredded and processed in battery recycling facilities. This complex mixture includes high concentrations of valuable minerals including lithium, which can cause rapid and premature degradation of the injector, combined with insoluble suspended carbon particles, which can also create a blockage risk.<h5>Who Should Attend:</h5>This webinar is recommended for any analyst or lab manager looking to improve efficiency and reduce downtime in their routine analysis workflows when running challenging sample matrices with their ICP-OES analyses, by utilizing a robust sample introduction system.<blockquote>Presenter: James Dellis (ICP-OES Supplies Product Manager, Agilent, Melbourne, Australia)James graduated from Swinburne University of Technology with a Bachelor of Science degree majoring in Chemistry and Biochemistry. Prior to joining Agilent, he worked within the Geochemical and Precious Metal industry. James joined Agilent in 2017 as an R&amp;D Applications Chemist for Supplies Product Development and is now the ICP-OES and Molecular Supplies Product Manager. He has over 13 years' experience in Analytical Chemistry and Atomic Spectroscopy. He is based at Agilent’s Spectroscopy Technology Innovation Centre in Melbourne, Australia.Presenter: Alejandro Amorin (Atomic Spectroscopy Applications Chemist, Agilent, Melbourne, Australia)Alejandro Amorin graduated from Universidad Central de Venezuela in Caracas, Venezuela with a Bachelor of Science degree with Honors, majoring in Chemistry. Prior to joining Agilent, Alejandro worked as a Research Chemist with DCG Partnership, developing new calibration standard blends for GC methods. Alejandro joined Agilent in 2012 as an Applications Chemist. He has worked on development of new spectroscopy consumables and provided applications support for Agilent spectroscopy instrument users around the world. Through his work experience, he has years of hands-on experience in diverse instrumental analysis techniques, including GC, IC, HPLC, AAS &amp; ICP combined with classical wet chemistry techniques. He is based at Agilent’s Spectroscopy Technology Innovation Centre in Melbourne, Australia.Presenter: Eric Vanclay (Marketing Director - Spectroscopy Supplies, Agilent, Melbourne, Australia)Eric Vanclay graduated from Monash University in Melbourne, Australia with a Bachelor of Science degree majoring in Chemistry in 1985, and has since completed further postgraduate studies in Marketing. He joined Varian in 1988 and has worked in a number of roles including Atomic Absorption Product Specialist, Atomic Absorption Product Manager, Export Marketing Manager, European Field Sales/Applications Specialist (atomic spectroscopy), ICP-OES Product Manager and MP-AES Product Manager. After the acquisition of Varian by Agilent, Eric took on the role of Spectroscopy Supplies Marketing Manager, with responsibility for field sales support, customer support, product development and marketing of the spectroscopy supplies. He has over 30 years' experience with all of the atomic spectroscopy techniques. He is based at Agilent’s Spectroscopy Technology Innovation Centre in Melbourne, Australia.</blockquote>

Separation Science: Improving Efficiency with Challenging ICP-OES Applications Utilizing a Robust Sample Introduction System

Improving Efficiency with Challenging ICP-OES Applications Utilizing a Robust Sample Introduction System

We'll provide an overview of some new sample introduction components that remove pain points around running challenging sample matrices by ICP-OES efficiently. 