<p><strong>Our Library never stops expanding. What are the most recent contributions to LabRulezICPMS Library in the week of 6th April 2026? Check out new documents from the field of spectroscopy/spectrometry and related techniques!</strong></p><blockquote><p><span style="font-size:20px;">👉 </span><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/library"><span style="font-size:20px;"><strong>SEARCH THE LARGEST REPOSITORY OF DOCUMENTS ABOUT SPECTROSCOPY/SPECTROMETRY RELATED TECHNIQUES</strong></span></a></p></blockquote><blockquote><p><strong>👉 Need info about different analytical techniques?</strong> Peek into <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/library"><strong>LabRulezLCMS</strong></a> or <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library"><strong>LabRulezGCMS</strong></a> libraries.</p></blockquote><p>This week we bring you application notes by <strong>Metrohm,</strong> <strong>Shimadzu, Thermo Fisher Scientific </strong>and <strong>Waters Corporation!</strong></p><h3><strong>1. Metrohm: Whey permeate analysis with NIRS</strong></h3><p><strong>Monitor dairy production processes easily in seconds</strong></p><ul><li>Application note</li><li><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/labrulez-bucket-strapi-h3hsga3/an_nir_144_download_34598659f1.pdf"><strong>Full PDF for download</strong></a></li></ul><p>Whey permeate, a byproduct of manufacturing whey protein powder, contains high amounts of lactose, phosphate, and minerals. Because of its sweet and mild taste, whey permeate is often used in bakeries and chocolate manufacturing. The key to optimizing whey permeate production is to control production streams in real time. It is important to monitor the production process with highthroughput analytical techniques to maximize product yield and ensure high product quality.&nbsp;</p><p>Nearinfrared spectroscopy (NIRS) is a fast, and chemicalfree analysis technique that can support this kind of testing. NIR spectroscopy can measure the most important quality parameters (i.e., protein, lactose, moisture, ash, pH, and phosphate) simultaneously in whey permeate without any sample preparation. The NIRS solution is fast, easy to operate, and can be used atline or offline in a quality control lab.</p><h4><strong>EXPERIMENTAL EQUIPMENT&nbsp;</strong></h4><p>158 whey permeate samples were analyzed on a <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/library?mainauthorItems=220&amp;search=NIR+analyzer"><strong>Metrohm NIR Analyzer</strong></a> equipped with a small cup accessory. All measurements were performed in reflection mode (1000–2250 nm). Metrohm software was used for data acquisition and prediction model development.</p><h4><strong>CONCLUSION&nbsp;</strong></h4><p>This Application Note demonstrates the feasibility of using NIR spectroscopy for whey permeate quality control. Near infrared-spectroscopy is a rapid, nondestructive analytical technique that can monitor the production process of dairy products. Aside from the analysis of whey permeate, the whey protein production stream can also be monitored by NIRS.</p><h3><strong>2. Shimadzu: Measurement of Residual Metal Catalysts by X-ray Fluorescence</strong></h3><ul><li>Application note</li><li><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/labrulez-bucket-strapi-h3hsga3/an_01_01086_en_4beb25fd1d.pdf"><strong>Full PDF for download</strong></a></li></ul><h4><strong>User Benefits</strong></h4><ul><li><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/library?mainauthorItems=1&amp;search=ALTRACE"><strong>ALTRACE</strong></a> can determine levels of heavy metals present in organic compounds at around 1 mg/kg in under 10 minutes per sample.</li><li>Analyzing and managing levels of residual metal catalysts can be performed by simply placing samples in the sample vessel and analyzing them without the need for complex sample pretreatment.</li><li>By increasing the X-ray tube power and optimizing the optical design, the sensitivity of ALTRACE for heavy metals has been<br>dramatically improved compared to the previous model.</li></ul><p>Many industrial products we encounter every day are produced from organic compounds by manufacturing processes that utilize a range ofsynthesisreactions and metal catalysts. Catalysis can be classified as either homogeneous or heterogeneous (although drug and chemical production processes typically use homogeneous catalytic systems). While homogeneous catalysis allows for precise control over catalytic reactions, recovering the catalyst after the reaction can be difficult.&nbsp;</p><p>Nevertheless, managing the levels of residual catalysts in industrial products is critical to ensure safety and because of their high costs. For example, the ICH Q3D Guideline for Elemental Impurities (adopted in April 2017) requires risk assessments when materials such as metal catalysts are added intentionally during a production process.&nbsp;</p><p>Energy dispersive X-ray fluorescence (EDXRF) spectrometry offers a simple but effective technique for assessing the levels of residual metal catalysts. Normally, the lower limit of quantification for EDXRF spectrometric analysis of heavy metals is above 1 mg/kg, which limitsits use in quantitative analysis. However, the <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/library?mainauthorItems=1&amp;search=ALTRACE"><strong>ALTRACE</strong></a> is equipped with a high-power X-ray tube that dramatically improves its sensitivity for heavy metals, enabling their determination at 1 mg/kg and below in lessthan 10 minutes. This Application News describes using ALTRACE to determine residual levels of a homogeneous catalyst after a synthesis reaction. The catalyst used in this analysis is palladium (Pd), which is a widely applied heavy metal catalyst, and the reaction catalyzed by the Pd catalyst is a cross-coupling reaction. A metal scavenger and activated carbon were each used to remove the Pd catalyst from the reaction products. Metal scavengers are frequently used in this role, and activated carbon offers a relatively cheap method for removing catalysts.</p><h4><strong>Conclusion&nbsp;</strong></h4><p>Common methods of elemental impurity analysis, such as atomic absorption spectrometry (AAS), ICP atomic emission spectroscopy (ICP-AES), and ICP mass spectrometry (ICP-MS), require liquid samples, so solid and powder samples must be prepared into a solution prior to analysis. However, EDXRF spectrometry can determine levels of elemental impurities regardless of the sample phase or form (solution, powder, etc.), provided the target element is distributed uniformly throughout the sample. The sensitivity of ALTRACE for heavy metals has been substantially improved compared to previous models, allowing for rapid quantitative determination of heavy metals at 1 mg/kg and below. Based on the performance presented in this article, ALTRACE is an effective tool for managing residual levels of metal catalysts.</p><h3><strong>3. Thermo Fisher Scientific: The Raman Spectroscopy of Graphene and the Determination of Layer Thickness</strong></h3><ul><li>Application note</li><li><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/labrulez-bucket-strapi-h3hsga3/raman_spectroscopy_graphene_determination_layer_thickness_an52252_29274e8aea.pdf"><strong>Full PDF for download</strong></a></li></ul><p>Currently, a tremendous amount of study is being directed toward graphene. This interest is driven by the novel properties that graphene possesses and its potential use in a variety of application areas that include but are not limited to electronics, heat transfer, bio-sensing, membrane technology, battery technology and advanced composites. Graphene exists as a transparent two-dimensional network of carbon atoms. It can exist as a single atomic-layer thick material, or it can be readily stacked to form stable, moderately thick samples containing millions of layers—a form generally referred to as graphite. However, the interesting properties exhibited by graphene (substantial electrical and thermal conductivity, high mechanical strength, and high optical transparency) are only observed for graphene films that contain only one or a few layers. Therefore, developing technologies and devices based upon graphene’s unusual properties requires accurate determination of the layer thickness for materials under investigation. Raman spectroscopy can be employed to provide a fast, non-destructive means of determining layer thickness for graphene thin films.</p><h4><strong>Instrument considerations&nbsp;</strong></h4><p>There are a few specifications that should be considered when selecting a Raman instrument for graphene characterization. First, since graphene samples are usually very small, selecting a Raman instrument with microscopy capabilities is imperative.</p><p>The next issue to consider is which excitation laser to select. While graphene measurements can be made successfully with any of the readily available Raman lasers, it is also important to consider the substrate that the graphene will be deposited onto. It is common for graphene to be deposited on on either Si or SiO2 substrates, and both of these materials can exhibit fluorescence with near-infrared (NIR) lasers such as 780 nm or 785 nm. For this reason, visible lasers are usually recommended, typically a 633 nm or 532 nm laser.&nbsp;</p><p>Next, since relatively small wavenumber shifts can significantly impact the interpretation of the Raman spectra, it is crucial to have a robust wavelength calibration across the entire spectrum. Using a single point wavelength calibration with some other applications may be sufficient, but this only ensures that one wavelength is calibrated and leaves room for a large margin of error. A multipoint wavelength calibration that is regularly refreshed, such as the standard calibration routine used with <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/products?category=184&amp;manufacturerItems=3&amp;search=dxr3"><strong>Thermo Scientific DXR3 Raman instruments</strong></a>, will provide considerably more confidence in the results. It is also necessary to have an instrument with high wavenumber precision to observe small wavenumber shifts when altering the sample. In fact, small wavenumber shifts can represent changes in the sample rather than represent the variability from the instrument. There is a common myth that it is necessary to utilize high resolution in order to achieve high wavenumber precision. Not only is this incorrect, but a high resolution will actually add considerable noise to the spectrum, which will add to the wavenumber variability. A high degree of wavenumber precision, such as that provided by the <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/products/2239"><strong>Thermo Scientific™ DXR™3 Raman Microscope</strong></a>, will significantly improve data confidence even when you are evaluating band shifts from low levels of strain or doping. It is also important to have exact control of your laser power at the sample and be able to adjust that laser power in small increments. This is important to control temperature-related effects and to provide flexibility to maximize Raman signal while still avoiding sample heating or damage from the laser. The DXR3 Raman systems are equipped with a unique device called a laser power regulator, which maintains laser power with unprecedented accuracy and provides exceptional ability to fine-tune laser power and optimize it for each experiment.<sup>1</sup>&nbsp;</p><p>Lastly, the Raman microscope must have an automated stage and associated software to generate detailed Raman point maps. As will be seen in the next section, Raman point mapping or imaging extends the single point measurement to assess a sample’s layer thickness uniformity. The <strong>Thermo Scientific OMNIC™ Software</strong> suite contains powerful mapping and processing tools that diminish the complexity of collecting highly detailed maps and interpreting their results.</p><h4><strong>Conclusions&nbsp;</strong></h4><p>Raman spectroscopy is an excellent tool for the characterization of graphene and layer thickness. Few techniques will provide as much information about the structure of graphene samples as Raman spectroscopy, and any lab doing graphene characterization without Raman would be at a significant disadvantage. The DXR3 Raman Microscope is an ideal Raman instrument for graphene characterization because it can provide the high level of stability, control, and sensitivity needed to produce confident results.</p><h3><strong>4. Waters Corporation: See What’s Really in Your Formulation with Backgrounded Membrane Imaging</strong></h3><ul><li>Application note</li><li><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/labrulez-bucket-strapi-h3hsga3/720009098_en_5d36d71789.pdf"><strong>Full PDF for download</strong></a></li></ul><p>Protein aggregation in therapeutic protein products can induce adverse immunogenic responses in patients<sup>1–4</sup> . Per the FDA’s recommendations, “strategies to minimize aggregate formation should be developed as early as feasible in product development”<sup>5</sup> and “an assessment should be made of the range and levels of subvisible particles (2–10 µm) present in therapeutic protein products initially and over the course of the shelf life”.<sup>5</sup> Yet, accurate subvisible protein aggregation analysis has remained elusive to protein drug formulators since current subvisible analyzers are not sensitive enough to measure protein aggregates effectively. In this application note, we explore how backgrounded membrane imaging (BMI), a high refractive index contrast technique used by the HORIZON particle analysis system, performs highly sensitive measurements of subvisible protein aggregates in the 2 µm–4 mm size range, enabling 30% higher reproducibility compared to flow imaging.</p><h4><strong>Conclusion&nbsp;</strong></h4><p>When studying the impact of protein aggregate refractive index, IgG protein aggregates analyzed on both the<strong> </strong><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/library?mainauthorItems=5&amp;search=HORIZON"><strong>HORIZON® instrument</strong></a> and flow imager systems produced equivalent particle count trends. However, the HORIZON® system was more sensitive (measured more overall counts) and had overall lower variability with average CVs of 14.4% compared to the flow imager which produced average CVs of 20.1%. The differences in variability and counts were most pronounced at lower concentrations and size range respectively. Given that most particles in a therapeutic drug formulation are small, the inability of flow imagers to accurately count the smallest of protein aggregates has a dramatic impact on the total number of particles measured. This can mean an undercounting by as much as 3–10X depending on the protein and formulation conditions.&nbsp;</p><p>High variability at low concentrations in flow imagers can pose a hurdle for early stage analysis were sample is scarce. In low volume analysis (&lt;250 µL), the possibility of measuring fewer particles increases, therefore it is imperative to have high sensitivity measurements when already challenged by low sampling statistics.&nbsp;</p><p>In the excipient effect study, sucrose did not have an impact on the overall particle counts when measured using the HORIZON® system. This contrasts with previous studies comparing excipient effects on three flow imagers.10 In each case, the particle counts decreased up to 30% or more using standard sucrose formulation concentrations of 0–20%. The difference between the data generated by BMI and FI can be attributed to the fact that the HORIZON® instrument is not affected by particle or solution refractive index.&nbsp;</p><p>Flow imagers are deeply vulnerable to the impact of refractive index when measuring protein aggregates due to their translucency and the negative impact of surfactants. Due to this basic optical phenomenon, flow imagers can dramatically undersize and undercount particles. Finding the right tool for the job will have a critical impact on data accuracy and sensitivity. Powered with BMI, the HORIZON® system provides high refractive index contrast analysis to enable accurate, robust, and sensitive subvisible particle counting from 2 µm–4 mm in as little as 25 µL of sample and 96 samples in under 2 hours.</p>

News from LabRulezICPMS Library - Week 15, 2026

<p><strong>The set of soils consist of two natural agricultural soils differing in elemental composition&nbsp;</strong></p><ul><li><strong>AN-ZP01:</strong> Heavy loam with normal analyte levels&nbsp;</li><li><strong>AN-ZP02:</strong> Silty clay loam contaminated with some heavy metals&nbsp;</li></ul><p>Contents of element extractable fractions with aqua regia according to ISO 11466&nbsp;</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/ANALYTIKA_agricultural_soil_CRM_0534e68e65.jpg" alt="ANALYTIKA: Matrix CRM of agricultural soil METRANAL® CRM AN-ZP01 and AN-ZP02" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_ANALYTIKA_agricultural_soil_CRM_0534e68e65.jpg 156w," sizes="100vw" width="827" height="827"></p><h5><strong>Packing:&nbsp;</strong></h5><ul><li>50 g of powder of the respective soil with a particle size of less than 100 µm in amber glass bottle.&nbsp;</li></ul><h5><strong>Intended use:&nbsp;</strong></h5><p>This set of certified reference materials is intended primarily for use in realizing metrological traceability, validation of analytical methods and the transfer of property values to other materials of similar composition.&nbsp;</p><h5><strong>Recommended analytical methods for method dependent measurements:</strong></h5><ul><li>Flame AAS, ETA-AAS, ICP-OES, ICP-MS, AMA-254&nbsp;</li></ul><h5><strong>Metrological traceability:&nbsp;</strong></h5><p>Metrological traceability is realized by using certified calibration standards solutions for the calibration of measurement methods used (direct traceability to SI unit) and/or by simultaneous analysis of a matrix CRM (RM) of similar composition.</p><h5><strong>Sample preparation (aqua regia extract according to ISO 11466):&nbsp;</strong></h5><p>Weigh a 3 g (± 0.001 g) sample into a 100 ml round bottom flask. Add a small amount of water (2 to 3 ml) to obtain a slurry, then 7.5 ml of conc. HNO<sub>3</sub> (density 1.40 g/ml). Let the mixture stand until intensive foaming ceases, then add (in several portions) 22.5 ml of conc. HCl (density 1.19 g/ml), shake the mixture manually, cover the flask with a watch glass, and let stand for 16 hours (overnight) at the laboratory temperature (20 ± 2°C). Then mount a reflux condenser (a Dimroth type or similar) of about 40 cm length on the top of the flask and boil gently under reflux for 2 hours. After cooling, rinse the condenser with 20 ml of warm (~ 50°C) dilute nitric acid (5%, v/v), the liquid being collected in the round bottom flask. Remove the condenser and filter the solution from the flask through an acid-resistant high density paper filter and collect it in a 100 ml volumetric flask (make sure in preliminary tests that a suitable filter was chosen, so that the filtrate is clear). Rinse the filter and the residue three times with 5 ml of warm (~ 50°C) dilute nitric acid (5%, v/v); allow to cool and dilute with nitric acid 5% (v/v) to the mark. Transfer immediately the solution from the volumetric flask into a clean, dry 100 ml polyethylene bottle. Realize three blanks using exactly the same analytical procedure.&nbsp;</p><p>It is acceptable to realize the operation described above in a glass beaker covered with a watch glass. Minimum sample size for analysis is defined with the prescribed working procedure.&nbsp;</p><h5><strong>Storing and instruction for use:&nbsp;</strong></h5><p>These CRM have to be stored in original bottle and between 5-30°C (in a dark and dry place). The materials should be analysed in the "as received" state and their dry weight should be determined on non-analysed aliquots oven-dried at 105°C till the constant weight. The material in the bottle must be rehomogenized before each use by mechanical shaking of the content for 1-2 minutes. The bottle should be opened a minimum of 2 minutes after rehomogenization in order to prevent an escape of fine powder particles from the bottle into the environment and their sedimentation.&nbsp;</p><h5><strong>Certified and indicative values and their uncertainties:&nbsp;</strong></h5><p>The certified and indicative values of extractable element fraction are summarized in Table 1. The overall means evaluated have been given a status of certified and indicative values using the following criteria: data should be available from at least two independent analytical methods, at least 5 and 3 accepted laboratory means should be available for calculation of the overall mean for certified and indicative value, respectively. At combined uncertainties presented, the contribution of uncertainty of characterization of a particular property value is dominant.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/ANALYTIKA_Table_1_Certified_and_indicative_values_of_contents_of_element_fractions_extractable_by_f56fa06aa5.jpg" alt="ANALYTIKA: Table 1 - Certified and indicative values of contents of element fractions extractable by aqua regia in CRM AN-ZP01 and AN-ZP02 and their associated uncertainties." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_ANALYTIKA_Table_1_Certified_and_indicative_values_of_contents_of_element_fractions_extractable_by_f56fa06aa5.jpg 187w," sizes="100vw" width="998" height="835"></p><h5><strong>Chemical composition of soil matrix:&nbsp;</strong></h5><p>The bulk composition of CRM AN-ZP01 and AN-ZP02 is shown in Table 2. The values presented in this table are not certified, but they may be useful for considerations concerning possible interferences while determining analytes given in Table 1, and for selection of suitable decomposition procedures if destructive analytical methods are to be used.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/ANALYTIKA_Table_2_Matrix_composition_of_CRM_AN_ZP_01_and_AN_ZP_02_of_the_oxides_dry_cd1273cf9c.jpg" alt="ANALYTIKA: Table 2 Matrix composition of CRM AN-ZP01 and AN-ZP02 (% of the oxides dry weight at 105°C)" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_ANALYTIKA_Table_2_Matrix_composition_of_CRM_AN_ZP_01_and_AN_ZP_02_of_the_oxides_dry_cd1273cf9c.jpg 170w," sizes="100vw" width="883" height="811"></p><h5><strong>Note:&nbsp;</strong></h5><p>Detailed information about the production, homogeneity testing and characterization of these CRM are described in the Certification report, which is available on request.</p>

Matrix CRM of agricultural soil METRANAL® CRM AN-ZP01 and AN-ZP02

<div><div><div><p><strong>Our immune system is incredibly powerful: among other things, it can recognize and destroy cancer cells. But tumors can be just as effective at avoiding detection – they build “invisibility shields” to protect themselves from attack.</strong></p></div></div><div><p>One breakthrough in cancer therapy has been immune checkpoint inhibitors (ICIs), drugs that reactivate immune T cells and help them fight tumors again. However, only about 20–50% of patients respond well to this treatment. Researchers are therefore seeking alternative therapeutic strategies. A small and well-known molecule called adenosine plays a key role in these efforts.</p><p>When tumor cells are stressed or dying, they release ATP, which is normally a signal that something is wrong in the tissue. But in the tumor microenvironment, ATP gets rapidly broken down by two enzymes, CD39 and CD73. Released adenosine acts like a chemical “calm-down” signal, binds to immune cells (T cells, NK cells, and others), and tells them to slow down, reducing their ability to kill cancer cells. Targeting CD73 therefore represents a promising strategy for developing new cancer treatments.</p></div><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/UOCHB_Nove_latky_mohou_podporit_imunitni_system_v_boji_s_rakovinou_88c5e82cd5.jpeg" alt="IOCB Prague: Development of potent inhibitors to boost the immune system's ability to fight cancer" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_UOCHB_Nove_latky_mohou_podporit_imunitni_system_v_boji_s_rakovinou_88c5e82cd5.jpeg 245w," sizes="100vw" width="661" height="363"></p><p>At IOCB Prague, interdisciplinary teams led by Jan Řezáč, Jan Konvalinka, and Michal Hocek used a newly developed high-throughput screening method to test over 5,000 compounds, identifying two ribonucleoside derivatives as promising CD73 inhibitors.</p><p>The scientists then improved the compounds’ activity by carefully modifying the ribonucleoside scaffold with bulky (het)aryl groups. Further optimization improved the pharmacokinetic properties of these compounds, yielding inhibitors with low clearance, long half-life, high solubility, and strong selectivity over related enzymes such as CD39.</p><p>In cellular experiments, the compounds reduced adenosine production in cancer cells, restored T cell activation, and showed no toxicity toward human fibroblasts. The most active compound showed a single-digit picomolar inhibition constant (Ki).</p><p>These findings establish a strong foundation for further in vivo efficacy and combination studies, which will explore the therapeutic potential of this novel inhibitor class.</p><blockquote><h4><strong>The Original article</strong></h4><h4><a target="_blank" rel="noopener noreferrer" href="https://pubs.acs.org/doi/10.1021/acsptsci.5c00707"><strong>Potent Competitive Inhibitors of Ecto-5′-nucleotidase (CD73) based on 6-(Het)aryl-7-deazapurine Ribonucleoside 5′-O-Bisphosphonates</strong></a></h4><p>Ugnė Šinkevičiu̅tė, Magdalena Šímová, Radek Staník, Lenka Poštová Slavětínská, Kristýna Blažková, Pavel Šácha, Martin Lepšík, Jan Řezáč, Jan Konvalinka, Tereza Ormsby, Michal Tichý, Michal Hocek</p><p><i><span><strong>ACS Pharmacol. Transl. Sci.</strong></span></i><strong> </strong><span><strong>2026, 9, 1, 191–213</strong></span></p><p><a target="_blank" rel="noopener noreferrer" href="https://pubs.acs.org/doi/10.1021/acsptsci.5c00707">https://pubs.acs.org/doi/10.1021/acsptsci.5c00707</a></p><h6>licensed under <a target="_blank" rel="noopener noreferrer" href="https://creativecommons.org/licenses/by/4.0/"><strong>CC-BY 4.0</strong></a></h6></blockquote><h4><strong>Abstract</strong></h4><p>CD73 generates immunosuppressive adenosine in the tumor microenvironment and is a promising target for cancer immunotherapy. We have designed and systematically studied diverse 2-substituted 7-deazapurine ribonucleoside 5′-<i>O</i>-bisphosphonates bearing a variety of (het)aryl groups at position 6 and discovered their highly potent and selective CD73 inhibition activity. The most active compounds (with single-digit picomolar <i>K</i><sub>i</sub>) contained bicyclic (het)aryl groups at position 6 in combination with chlorine at position 2. Further optimization of pharmacokinetic properties identified inhibitors with low clearance, long half-life, high solubility, and excellent selectivity over CD39 and NTPDase3. They effectively suppressed adenosine formation in MDA-MB-231 cells, rescued CD8<sup>+</sup> T cell activation, and were nontoxic to human fibroblasts. Overall, their profile compares favorably with <strong>AB680</strong>, a CD73 inhibitor currently in phase I/II clinical trials.</p></div>

Development of potent inhibitors to boost the immune system's ability to fight cancer

Article

Product

Application

Scientific article

Science and research

The Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences (IOCB Prague) is a leading scientific institution in the Czech Republic, recognized internationally. Its primary mission is basic research in the fields of chemical biology and medicinal chemistry, organic and material oriented chemistry, chemistry of natural compounds, biochemistry and molecular biology, physical chemistry, theoretical chemistry, and analytical chemistry. 

Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences

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LabRulez

Analytika is a Czech company that offers and produces certified reference materials (CRM) and (ultra)pure chemicals for quality control and quality assurance in laboratories, including accredited laboratories.

Our portfolio also includes pipettes and tips, digestors, PFA labware and other equipment for analytical laboratory and trace analysis.

ANALYTIKA

Mettler-Toledo

Anton Paar

Agilent Technologies

SPECTRO Analytical Instruments

Milestone

Bruker

Waters Corporation

<p><strong>Techniques on how to achieve the best sensitivity and detection limits through tuning techniques and strategies.</strong></p><blockquote><p><strong>Presenter:</strong> Ana García González (Atomic Spectroscopy Application Scientist, Agilent Technologies)</p><p>Ana Garcia is the Atomic Spectroscopy Application Scientist at Agilent Technologies. Ana has a broad background in atomic spectroscopy technologies, including international experience developing and validating analytical spectroscopy methods for the geochemical industry. She has also published in the fields of molecular spectroscopy and chemometrics. Ana holds a MSc in plant Biotechnology at CINVESTAV, México, and a Bachelor of Science in Biotechnology Engineering.</p></blockquote>

Agilent Technologies: Tips and Tricks Workshop on ICP-OES: Smarter Method Development

Tips and Tricks Workshop on ICP-OES: Smarter Method Development

Techniques on how to achieve the best sensitivity and detection limits through tuning techniques and strategies.

Tips and Tricks Workshop on ICP-OES

<p><strong>While many Semiconductor applications call for ppt levels and ICPMS analysis, there are many applications in this market that can utilize and ICP-OES for the analysis.</strong></p><p>Matrices mainly include high silicon levels or looking for traces in a variety of reagents, both inorganic and organic. This master class will look at handling high silicon as well as inorganic reagents like H2O2, HNO3, H2SO4, H3PO4…. ICP is well suited for organic reagent analysis as well. This presentation will also include organic solvent setup and optimization.</p><blockquote><p><strong>Presenter:</strong> Paul Krampitz (Application Scientist, Agilent Technologies, Inc.)</p><p>Paul is a graduate of Bowling Green State University with a Chemistry Bachelor of Science degree. Twenty – five years of Spectroscopy experience mainly Inductively Coupled Plasma (ICP) Spectroscopy as well as ICP-MS and AAS. His experience also includes X-Ray Fluorescence (ED, WD), Laser Ablation, Inorganic Speciation and Microwave Plasma Spectroscopy. Market Segment expertise includes environmental, petrochemical, metallurgical applications.</p><p><strong>Presenter: </strong>Sima Singha, PhD (ICP-OES Application Scientist, Atomic Spectroscopy, Agilent Technologies, Inc.)</p><p>Sima has over fifteen years of hands on experience as an applications scientist in the field of atomic spectroscopy. Before joining Agilent in 2017, managed an agricultural chemistry laboratory for the analysis of water, soil, and plant tissue digests using ICP-OES for various EPA methods. She received a Ph.D. degree in Chemistry from the University of Illinois at Chicago with numerous peer-reviewed publications.</p></blockquote>

Agilent Technologies: Semiconductor Applications and Setup for a variety of Solvents and Matrices by ICP-OES

Semiconductor Applications and Setup for a variety of Solvents and Matrices by ICP-OES

Learn how ICP-OES enables semiconductor analysis of silicon-rich samples and reagents, offering robust trace detection and optimized solvent workflows.

Semiconductor Applications and Setup for variety of Solvents

<p><strong>Measuring scattering samples with UV-VIS-NIR can be challenging for basic instruments. These samples will have diffuse reflectance or transmission and less light hitting your detector.</strong></p><p>In this presentation, we will discuss diffuse reflectance accessories (DRAs) for collecting all light in a measurement as well as Agilent's universal measurement accessory (UMA) for measuring the angular distribution of the reflected light.</p><blockquote><p><strong>Presenter:</strong> Scott Melis, PhD (Application Scientist, Agilent Technologies, Inc.)</p><p>Scott Melis has a PHD in Physics from Georgetown University in Washington, DC and started with Agilent in 2021 as a Molecular Spectroscopy Application Scientist. In his graduate work, Scott studied nanoparticle formation and growth for a variety of applications. Projects that he worked with include developing processes to deposit and characterize semiconducting molecular nano-cocrystals for use in optoelectronic devices as well as controlling polymer nanoparticle size through rapid mixing conditions.</p></blockquote>

Agilent Technologies: Measuring Diffuse Powders and Films With UV-VIS-NIR

Measuring Diffuse Powders and Films With UV-VIS-NIR

We will discuss diffuse reflectance accessories (DRAs) as well as Agilent's universal measurement accessory (UMA).

<p><strong>Long pathlength cuvettes are critical options for improving UV-VIS sensitivity. With pathlengths greater than traditional 1 cm, you can improve concentration analysis detection limits.</strong></p><p>The Cary 3500's flexible sampling options make this concentration analysis more effortless than ever before.</p><blockquote><p><strong>Presenter:</strong> Scott Melis, PhD (Application Scientist, Agilent Technologies, Inc.)</p><p>Scott Melis has a PHD in Physics from Georgetown University in Washington, DC and started with Agilent in 2021 as a Molecular Spectroscopy Application Scientist. In his graduate work, Scott studied nanoparticle formation and growth for a variety of applications. Projects that he worked with include developing processes to deposit and characterize semiconducting molecular nano-cocrystals for use in optoelectronic devices as well as controlling polymer nanoparticle size through rapid mixing conditions.</p></blockquote>

Agilent Technologies: Effortless UV-VIS Analysis with Long Pathlength Measurements

Effortless UV-VIS Analysis with Long Pathlength Measurements

The Cary 3500's flexible sampling options make this concentration analysis more effortless than ever before.

UV-VIS Analysis with Long Pathlength Measurements

<header><h4><strong>How to Determine the Thermal and Mechanical Properties of Electronic Materials</strong></h4></header><main><div><div><h5><strong>Program</strong></h5><ul><li>Introduction to electronics and PCBs</li><li>How thermal analysis is used in the electronics industry</li><li>Introduction to thermal analysis techniques</li><li>Real-life application examples using DSC, TGA, TMA, and DMA</li><li>Interactive Q&amp;A session</li></ul></div></div><div><div><div><p>The field of electronics involves components such as transistors, diodes, wires and integrated circuits, which are usually mounted on printed circuit boards (PCBs). PCBs are classified as composite material and consist of a carrier material, typically a glass fiber fabric, and a matrix such as epoxy resin.</p><p>The thermal and mechanical properties of electronic components have a significant effect on their use case and lifetime. For example, PCBs can suffer from delamination at high temperatures. Thermal analysis can be used to characterize many types of components and to guide design and production processes.</p><p>Join our upcoming webinar to find out how thermal analysis is used to investigate materials used in the electronics industry. We will present real-life examples of samples measured by DSC, TGA, TMA, and DMA. Understand your material behavior and boost your thermal analysis knowledge.</p><h4><strong>How Is Thermal Analysis Used for Characterizing Electronic Components?</strong></h4><p>The most important effects that can be analyzed by DSC for the electronics industry are curing, glass transitions, crystallization, and melting temperature. DSC is also used to determine the heat of fusion, and oxidation stability.</p><ul><li><strong>TGA </strong>measures weight changes. The main applications of TGA are thermal stability, decomposition kinetics, and the analysis of composition.</li><li><strong>TMA</strong> is normally used to study the expansion, shrinkage, and softening of materials and the glass transition.</li><li><strong>DMA</strong> is used to determine the modulus and damping behavior of materials.</li></ul><p>Don’t miss this opportunity to gain in-depth knowledge on characterizing electronic materials, such as PCBs, adhesives, solder, metals, alloys, composites, and plastics. Register now to secure your spot, and be sure to prepare your questions for our experts!</p></div><div><div data-advanced-option="false" data-has-preview-image="false" data-video-id="" data-component-id="2110920040"><div style="max-width:1px;width:100%;" id="mediaContainerWrapper_2110920040"><div style="height:1px;width:1px;" data-external-url="" id="mediaContainer_2110920040" data-advanced-option="false" data-width="1" data-height="1" data-video-id="">&nbsp;</div></div></div></div></div></div></main><div><div><div data-advanced-option="false" data-has-preview-image="false" data-video-id="" data-component-id="2110920040"><blockquote><div><strong>Presenter: </strong>Angela Hammer (Dr. sc. nat. ETH)</div><p>Dr. Angela Hammer received a Ph.D. in Analytical Chemistry (development of immobilized components for the use in ion-selective electrodes based on polyurethane membranes) from the Institute of Organic Chemistry at the Swiss Federal Institute of Technology in Zürich, Switzerland. She then joined Sika Technology AG in Zurich, Switzerland, as an analytical chemist. In 2007, she joined METTLER TOLEDO and has worked there since as an application specialist for Thermal Analysis. In her present position, she uses, teaches, and supports DSC, TGA, TMA, and DMA instruments for the METTLER TOLEDO’s Materials Characterization Group located at the head office in Switzerland.</p></blockquote></div></div></div>

Mettler Toledo: Thermal Analysis of Electronic Components

Thermal Analysis of Electronic Components

Discover how thermal analysis (DSC, TGA, TMA, DMA) characterizes electronic materials and PCBs, supporting design, reliability, and lifetime performance.

<div><p><strong>Recently, Hitachi’s TM4000PlusⅢ microscopes and Bruker’s QUANTAX EDS system have undergone significant improvements to allow high-throughput elemental analyses (QUANTAX 75-60). In this webinar, in collaboration with Hitachi, we will demonstrate that EDS analyses once limited to high-end systems are now reproducible with a compact and user-friendly SEM.</strong></p><p>With the introduction of the new TM4000PlusⅢ tabletop electron microscopes higher probe currents have become available which allows for even higher EDS productivity.</p><p>Bruker’s QUANTAX EDS solution now maximizes analytical throughput with high beam currents. The latest ESPRIT Compact software includes the LiveMap function to identify regions of interest in real time and improve workflow efficiency.</p><p>To the end user, these new changes translate to enhanced intuitiveness and substantially improved acquisition speed and data quality, allowing challenging samples to be analyzed in a few minutes (e.g., beam-sensitive, with high topography or containing lots of chemical elements).</p><p>During the webinar the new features of the TM4000PlusⅢSEMs will be presented, higher probe current, filament indicator, probe current monitor as well as new no-code/low-code automation tools. Powerful tools that can make the compact SEM do complex automated tasks similar to a large full-scale system. &nbsp;</p><p>Achieve high-quality elemental mapping of diverse materials in less than 5 minutes (like battery, powders, alloys, mineralogy).</p><p>Effortlessly identify and quantify small particles and heterogeneities in complex or embedded samples.</p><h4><strong>Who should attend?</strong></h4><ul><li>Microscopists and laboratory managers interested in facilitating and expanding routine analytical capabilities.</li><li>Academic and industry researchers in materials science, metallurgy, geology, and battery research seeking efficient microanalytical workflows.</li></ul><blockquote><p><strong>Presenter:</strong> Jürgen Simon (Sales Manager, Hitachi High-Tech Europe)</p><p><strong>Presenter: </strong>Julien Aubourg (Application Scientist EDS, Bruker Electron Microscope Analyzers)</p></blockquote></div>

Bruker: Optimized Elemental Analysis with Tabletop Electron Microscopes

Optimized Elemental Analysis with Tabletop Electron Microscopes

High-throughput EDS with Hitachi TM4000PlusⅢ and Bruker QUANTAX, featuring rapid elemental mapping, automation tools, and improved data quality.

Elemental Analysis with Tabletop Electron Microscopes

<div><h4><strong>Unlock the Secrets of Lipid Nanoparticle Characterization</strong></h4><p><strong>Join our exclusive webinar and discover how to overcome the toughest challenges in LNP analysis.</strong></p><p>Are you working with lipid nanoparticles, liposomes, or other lipid-based drug carriers? Whether you’re in discovery, development, QC, or analytical services, or supporting these efforts in a CRO or biotech institute, this session is for you!</p><h4><strong>What you’ll gain:</strong></h4><ul><li><strong>Boost Lab Efficiency: </strong>Learn how automated zeta potential and size measurements for up to 96 samples in a single run free your team to focus on science, not repetitive tasks.</li><li><strong>Master Challenging Samples: </strong>See how Flow Mode preserves sample integrity and delivers precision, even at physiological ionic strength.</li><li><strong>Simplify Your Workflow:</strong> Experience intuitive guided workflows and DYNAMICS Software, fully 21 CFR Part 11–compliant, to ensure data integrity and smooth transition from research to QC.</li></ul><h4><strong>Why attend?</strong></h4><p>Traditional methods struggle with high-salt media, low-charge samples, and regulatory scrutiny. We’ll show you how the DynaPro ZetaStar solves these pain points, delivering accurate, reproducible results with less than 10% RSD, full compliance, and automation that scales with your needs. Plus, discover how DYNAMICS Software and DYNAMICS Touch make complex analyses simple, reliable, and fast, even from microliter volumes.</p><p><strong>Don’t miss this chance to transform your LNP characterization process.</strong></p><p><i>Reserve your spot today and take the first step toward faster, more reliable insights.</i></p><blockquote><p><strong>Presenter:</strong> Richard Chung (Lab Analytics Product Manager, Waters | Wyatt Technology)</p><p>Since joining Wyatt in 2016, he has held key roles, including Application Scientist and Customer Support Manager, where he worked closely with researchers to solve complex analytical challenges. Now, as a Product Manager, Richard bridges the gap between scientists and better instruments - gathering insights from the field and collaborating with internal research teams to develop cutting-edge solutions that empower laboratories worldwide.</p></blockquote></div>

Waters Corporation: Automation, Speed, and Simplicity for Total Lipid Nanoparticle Characterization

Automation, Speed, and Simplicity for Total Lipid Nanoparticle Characterization

Join our exclusive webinar and discover how to overcome the toughest challenges in LNP analysis.

Total Lipid Nanoparticle Characterization

<div><div id="inner_content_body_text" data-content-id="394785"><h3><strong>Unlock the future of rheology for pharma and regulated industries!</strong></h3><p>In the highly regulated world of pharmaceuticals and related industries, precision and compliance are everything. Join us for an exclusive session on how the next generation of rheometers and software solutions is transforming R&amp;D, QC, and production testing across pharmaceutical and biotech applications.</p><h4><strong>Why you should attend:</strong></h4><ul><li>Explore the <strong>new</strong> <strong>MCR Rheometer Series</strong> – ushering in the next era of rheological performance and automation.</li><li>Discover rheological solutions for low-viscosity protein samples, semi-solids, and powders.</li><li>Learn how rheology supports shelf life, stability, and artificial tissue development.</li><li>See how to adapt your rheometer for powder flow and syringe testing.</li><li>Experience <strong>RheoCompass software</strong> in action – ensuring data integrity and compliance in regulated environments.</li></ul><p>Join us to make every formulation stronger, smarter, and more reliable.</p><blockquote><p><strong>Presenter:</strong> Dr. Andre Braun</p></blockquote></div></div>

Anton Paar: Next-Generation Rheology for Pharma: Precision at 0.2 nNm and Beyond

Next-Generation Rheology for Pharma: Precision at 0.2 nNm and Beyond

Explore advanced rheology for pharma: next-gen MCR rheometers, RheoCompass software, and compliant solutions for R&D, QC, stability, and production testing.

Next-Generation Rheology for Pharma

<p><strong>Environmental laboratories face increasing pressure to process complex matrices for both inorganic and organic contaminants with higher efficiency, lower cost, and full regulatory compliance. This four-part webinar series provides a comprehensive overview of modern sample preparation solutions for heavy metals, mercury, and organic pollutants, including PFAS.&nbsp;</strong></p><p>Through practical guidance and real-world examples, we will explore how advanced digestion, extraction, and direct analysis tools streamline workflows, minimize errors, and improve data quality. Participants will gain actionable strategies to enhance productivity and achieve more reliable environmental results across the entire sample-to-analysis journey.</p><h4><strong>Episode 1: New microwave digestion tools for heavy metals analysis of environmental samples</strong></h4><p>Closed-vessel microwave digestion has become the benchmark for preparing environmental samples for trace metals analysis. As laboratories face growing demands for faster turnaround, improved accuracy, and lower operational costs, modern microwave platforms offer significant advantages. This webinar introduces the new Milestone’s digestion solutions, including ETHOS LEAN, ETHOS, and ultraWAVE 2 eco, and demonstrates how they improve sample throughput, minimize reprocessing, and enhance data quality. Through practical examples and best practices, attendees will learn how these new tools streamline daily workflows and reduce the overall cost per sample while supporting even the most challenging environmental applications.</p><blockquote><p class="cke-user_style-important"><a target="_blank" rel="noopener noreferrer" href="https://share.hsforms.com/1b7diMdH_QtaH4bNUuW_T9Q5dmem"><strong>Register HERE</strong></a></p></blockquote><blockquote><p><strong>🎤Speaker:</strong> Giulio Colnaghi (Marketing Manager, Milestone Srl)</p></blockquote>

Milestone: Environmental Sample Prep Series 2026

New microwave digestion tools for heavy metals analysis of environmental samples

How advanced microwave digestion systems streamline environmental heavy metals analysis, improving efficiency, data quality, and cost per sample in modern labs.

Microwave digestion tools for heavy metals analysis

<p><strong>As the use of permanent magnet electric motors grows, so does the interest in analyzing rare earth element (REE) content in their magnets. Heavy REEs, added at concentrations of 1–8%, play a crucial role in boosting these magnets’ resistance to high temperatures.</strong></p><p>Interest has grown following China’s Ministry of Commerce Announcement No. 18 in April 2025, restricting exports of several medium and heavy rare earth elements—such as Sm, Gd, Tb, Dy, Lu, Sc, and Y—followed by Announcement No. 57 in October 2025, which brought Ho, Er, Tm, Eu, and Yb under similar controls.</p><p>Traditionally, REE analysis relies on sample digestion and ICP‑based techniques. In contrast, X‑ray fluorescence (XRF) spectrometry offers faster workflows by eliminating digestion, reducing reagent consumption, and supporting high‑volume elemental analysis. And with a small and focused analysis spot, advanced XRF analyzers excel at examining small magnets—including those within partially assembled or partially disassembled electric motors—without the need for complex sample preparation.</p><p>As global magnet recycling rates remain low, demand for effective reprocessing is increasing. XRF technology helps meet this demand by enabling rapid and accurate material identification and elemental analysis.</p><p>Attendees will explore real‑life cases where small‑spot ED‑XRF enables the analysis of compact, mounted, or partially disassembled magnets, demonstrating how modern solutions streamline magnet quality control and recycling workflows.</p><h4><strong>Why attend:</strong></h4><ul><li>Gain practical insights on integrating ED‑XRF into rare earth element workflows for faster decision‑making</li><li>Understand how ED‑XRF supports regulatory compliance and recycling initiatives</li><li>Improve laboratory efficiency with methods that minimize sample preparation</li></ul><h4><strong>Who Should Attend:</strong></h4><ul><li>Quality control and process optimization professionals</li><li>Laboratory and production managers</li><li>Anyone interested in advanced analytical technologies</li></ul><p>The webinar will take place on Thursday, February 5, and will take around 30 minutes, after which we'll answer your questions live.</p><h4><strong>Join us live:</strong></h4><ul><li>9:30 AM CET (Berlin); 4:30 PM SGT (Singapore) — Time Slot 1</li><li>11:00 AM EST (New York); 5:00 PM CET (Berlin) — Time Slot 2</li></ul><blockquote><p><strong>Presenter:</strong> Dirk Wissmann</p><p>Dirk Wissmann is the Product Manager for XRF instruments at SPECTRO Analytical Instruments and is responsible for the strategic development of the complete product line including application development and product support. Dirk’s experience in spectroscopy began with his graduate work in physics at the university in Siegen, Germany. He moved to SPECTRO in 1990 with assignments in quality control, training, application development, and marketing.</p></blockquote>

SPECTRO / AMETEK: Rare Earth Magnet Analysis: The Role of XRF in Production and Recycling

Rare Earth Magnet Analysis: The Role of XRF in Production and Recycling

Discover how ED-XRF simplifies rare earth element analysis in permanent magnets. Faster workflows, minimal prep, and practical insights for QC and recycling.

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