Our Library never stops expanding. What are the most recent contributions to LabRulezICPMS Library in week 40, 2024? Check out new documents from the field of spectroscopy, especially ICP/MS techniques!<blockquote>👉 <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/library">SEARCH THE LARGEST REPOSITORY OF DOCUMENTS ABOUT ICPMS AND RELATED TECHNIQUES</a></blockquote><blockquote>👉 Need info about different analytical techniques? Peek into <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/library">LabRulezLCMS</a> or <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library">LabRulezGCMS</a> libraries.</blockquote>This week we bring to you applications by Agilent Technologies, Shimadzu, and Metrohm and a poster by Thermo Fisher Scientific!<h4>1. Agilent Technologies: <style type="text/css"></style><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/labrulez-bucket-strapi-h3hsga3/an_v_groove_nebulizer_5994_7788en_agilent_4ae77b4b3a.pdf">Reducing Instrument Downtime in Elemental Analysis of Lubricant Oils as per ASTM 5185</a></h4><ul><li>Application</li></ul><h5>Run samples faster and for longer using the V-groove nebulizer</h5>AbstractIn this application note, lubricant oil samples were analyzed using an Agilent 5900 Synchronous Vertical Dual View (SVDV) inductively coupled plasma optical emission spectrometer (ICP-OES) coupled with an Agilent Advanced Valve System 6 (AVS 6) and the Agilent V-groove nebulizer to enable the rapid analysis of over 1,000 samples in 6 hours (more than 160 samples per hour). The V-groove nebulizer provides exceptional performance characteristics, robustness, and durability, even when using troublesome samples. It also provides a reduction in sample loading on the plasma, which reduces carbon formation on the injector of the torch, allowing extended run times, while exceeding the sensitivity requirements required for the ASTM D5185-18 standard method.IntroductionElemental analysis of lubricant and hydraulic oils is essential for predictive and preventive maintenance, as well as trend analysis in many heavy industries. The ASTM D5185‑18 standard method1 is the gold standard in tribology laboratories globally to quantify additive elements, wear metals, and contaminants. This method uses ICP-OES for the rapid elemental determination of 22 elements in both used and unused lubricating and base oils, providing quick screening of used oils for signs of wear.Tribology laboratories typically process hundreds of samples daily; therefore, they are constantly searching for ways to enhance efficiency and improve sample throughput. Instrument downtime caused by blockages in the sample introduction system (SIS) can be a common problem in these high-throughput labs. These blockages are typically caused by suspended particles in the samples blocking the nebulizer, and carbon deposits blocking the injector of the torch. Although various methods exist to remove the blockage from the nebulizer and clean the torch, all require extinguishing the plasma to remove and clean the SIS.The use of a robust nebulizer is a strategy that can enable tribology laboratories to run more samples with reduced blockage. This will improve their workflows and increase sample throughput, reducing both instrument downtime and their running costs. One example of a robust nebulizer that helps to overcome the blockage issues is the inert, high-total-dissolved-solids (high-TDS) Agilent V-groove nebulizer, which is capable of aspirating highly dissolved solids and slurries (up to 30% dissolved solids with a maximum particle size of 350 μm). Its inert construction also ensures that any solvent can be nebulized.In this application note, used diesel engine lubricant oil samples were analyzed using the 5900 SVDV ICP-OES coupled with the AVS 6 and the V-groove nebulizer, following the ASTM D5185-18 standard method.&nbsp;ConclusionThis application note shows the suitability of the Agilent 5900 SVDV ICP-OES used with the Agilent AVS 6 and inert V-groove nebulizer for rapid multi-element analysis of used lubricant oil samples using the ASTM D5185-18 standard method.Excellent long-term stability was demonstrated when more than 1,000 samples were analyzed over a six-hour period (22 to 23 seconds per sample). All measurements of this spiked oil sample were within ± 10% of the expected value, with precision better than 5% RSD in most cases. The spike recovery study showed how the 5900 ICP-OES, used with the inert V-groove nebulizer, can accurately detect low range concentrations of wear metals and high concentrations of the elements from the additive package in a single analysis. The inert V-groove nebulizer also enabled the samples to be run faster, with excellent accuracy.Despite no oxygen injection being used, there were no signs of blockage of the injector of the torch, or carbon deposition after the test. The V-groove nebulizer design reduces sample loading on the plasma, minimizing carbon buildup while maintaining the sensitivity required for the ASTM D5185 standard method. No nebulizer blockage was experienced while collecting the data for this study. The inert V-groove nebulizer allows extended run times by reducing the frequency of torch and nebulizer maintenance. This demonstrates the stability of the 5900 ICP-OES and the suitability of the inert V-groove nebulizer for high-throughput tribology laboratories, by reducing instrument maintenance downtime and improving sample throughput.<h4>2. Thermo Fisher Scientific: <style type="text/css"></style><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/labrulez-bucket-strapi-h3hsga3/pn_002807_tea_icp_ms_halogens_wpc_2024_pn002807_en_b235f7ba82.pdf">WPC: Sensitive and interference free analysis of halogens using triple quadrupole ICP-MS</a></h4><ul><li>Poster / WPC</li></ul>ABSTRACTThe analysis of halogens is important in many different industries, such as environmental monitoring, pharmaceutical, oil and gas, but also Li-ion battery and renewable fuels. Halogen analysis is commonly carried out using ion chromatography (IC), whereas argon plasma-based techniques like ICP-MS are less common, due to poor sensitivitiy, and potential spectral interferences. This study describes a complete analytical workflow using the Thermo Scientific™ iCAP™ TQe ICP-MS for the accurate and precise quantification of challenging halogen analytes like fluorine, chlorine, and bromine.CONCLUSIONSThis work highlights how triple quadrupole ICP-MS systems, such as the iCAP TQe ICP-MS, operated in TQ-O 2 mode can be used for accurate and precise quantification of challenging analytes such as halogens.<ul><li>It could be shown that chlorine and bromine can be analyzed directly using optimized instrument conditions.</li><li>It further highlights the feasibility of iCAP TQe ICP-MS for indirect but accurate and precise determination of fluorine by following approach of complex formation with barium under optimized and controlled conditions</li><li>The analytical data and observations made during this study strongly suggest that iCAP TQe ICP-MS equipped with dedicated mass flow controllers (MFCs) for introduction of pure oxygen and pure helium as cell gases is a powerful tool to accomplish the otherwise challenging analysis of halogens.</li><li>Upcoming studies will focus on the application of the fluorine measurements in hyphenated techniques, such as liquid chromatography hyphenated to ICP-MS to assess the potential for emerging contaminant screening, i.e. of PFAS</li></ul><h4>3. Shimadzu: <style type="text/css"></style><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/labrulez-bucket-strapi-h3hsga3/an_01_00772_en_4935e06938.pdf">Analysis of Elemental Impurities in Anode Materials for Lithium-Ion Secondary Batteries Using the ICPE- 9820</a></h4><ul><li>Application</li></ul>User Benefits<ul><li>Elemental impurities in the anode materials of lithium-ion secondary batteries can be measured.</li><li>Even after measurement, elements and wavelengths can be added to check for unexpected elemental impurities in the anode materials.</li><li>The system uses a mini torch that consumes less argon gas, thus reducing running costs.</li></ul>IntroductionLithium-ion secondary batteries (LIBs) are widely used in mobile devices, electric vehicles, hybrid cars, and more. One of the components of LIBs, the anode, accumulates and releases Li ions during charging and discharging. Graphite-based materials are mainly used as the anode material in LIBs. In China, one of the major producers, the analysis of elemental impurities in graphite, which is used as LIB anode material, is required by GB/T 24533-20191) using inductively coupled plasma atomic emission spectroscopy (ICP-AES).In this Application News, elemental impurities in LIB anode materials were analyzed using the ICPE-9820. Spike recovery tests were performed to confirm the validity of the analytical values. Additionally, the “Acquisition for All Wavelength” feature allows for checking the presence of elemental impurities that were not subjected to quantitative analysis.ConclusionIn this Application News, an analysis of elemental impurities in LIB anode materials was performed using the ICPE-9820. Good spike recoveries were obtained, confirming the accuracy of the analysis. Additionally, elements and wavelengths were added after the measurement to identify elemental impurities other than the analyzed elements present in the anode materials.<h4>4. Metrohm: <style type="text/css"></style><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/labrulez-bucket-strapi-h3hsga3/an_pan_1064_download_39b556efd8.pdf">Monitoring complexing agents in galvanic baths inline with Raman spectroscopy</a></h4><ul><li>Application</li></ul>The main purposes of galvanic process baths include the surface refinement of workpieces and the setting of physical properties. To this end, bath additives (e.g., organic compounds or complexing agents) are regularly added in different amounts, depending on the processing load. Since the bath composition changes continuously due to the introduction of the workpieces, close monitoring of the concentration of the bath additives is necessary to ensure that the end product quality is at the highest level.This Process Application Note presents a method to accurately analyze complexing agents inline in galvanic baths with a 2060 Raman Analyzer from Metrohm Process Analytics. This enables real-time bath control and thus an increase in production efficiency and product quality.CONCLUSIONRaman spectroscopy is an easy-to-use analytical technique that identifies liquids and solids within seconds. The 2060 Raman Analyzer from Metrohm Process Analytics is a high-performance Raman system designed for monitoring different processes like electroplating.Together with Metrohm’s Vision and IMPACT software, the 2060 Raman Analyzer can be used to acquire real-time results, increase roductivity, and lower production costs.

News from LabRulezICPMS Library - Week 40, 2024

<h4>The Science</h4>Nuclear magnetic resonance (NMR) spectroscopy is used to detect and identify the structure of molecules, and it has become increasingly important in environmental science. The data produced from NMR analyses need a lot of additional processing to be useful. This makes it difficult for nonexperts to use and apply this technique. We introduce a new R package, called nmrrr, to process and visualize NMR data. This open-source package can be integrated into existing NMR processing workflows. The package can be used to process spectra and peak data, calculate relative abundances, and plot graphs of spectra. The nmrrr package is currently available on two platforms: CRAN and GitHub.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Pacific_Northwest_National_Laboratory_Kaizad_F_Patel_New_Soft_An_R_Package_for_NMR_Data_Processing_The_nmrrr_package_can_be_used_to_process_spectra_from_solution_and_solid_state_13f448377b.jpg" alt="Pacific Northwest National Laboratory / Kaizad F. Patel: The nmrrr package can be used to process spectra from solution- and solid-state." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Pacific_Northwest_National_Laboratory_Kaizad_F_Patel_New_Soft_An_R_Package_for_NMR_Data_Processing_The_nmrrr_package_can_be_used_to_process_spectra_from_solution_and_solid_state_13f448377b.jpg 208w," sizes="100vw" width="1600" height="1200"><h4>The Impact</h4>Despite advances in NMR analyses, manual integration and data processing are still the norm for environmental sample workflows. The nmrrr package is intended for processing NMR data, including cleaning data from multiple files, visualizing NMR spectra, performing binning/integrations for functional groups, and calculating relative abundances. A major feature of this package is its ability to batch-process multiple samples in a reproducible manner. This package is designed for use in the R language for statistical computing, and it can be easily inserted into analysis workflows to help analyze and interpret NMR data. The nmrrr package has a wide range of applications, as it can be used for various target nuclei, solution- and solid-state NMR data, and high-resolution magic-angle-spinning (HRMAS, gel-state NMR) data.<h4>Summary</h4>NMR spectroscopy is a useful tool for the detection and identification of molecular structural information and has increasing applications in environmental sciences. However, the outputs from NMR instruments contain many differences and require extensive post-processing, creating barriers to their use and application by nonspecialists. The nmrrr package processes and visualizes the spectral data obtained from one-dimensional solution- and solid-state NMR experiments. It also performs the relevant calculations commonly applied in natural organic matter communities, such as computing the relative abundances of various functional groups. In the publication below, the package’s installation, dependencies, and functions are documented, and a standard workflow for processing NMR data is presented. This package is currently available on CRAN and GitHub, and community contributions are welcome.<h4>Contact</h4>Kaizad F. Patel, Pacific Northwest National Laboratory,&nbsp;<a href="mailto:kaizad.patel@pnnl.gov">kaizad.patel@pnnl.gov</a><h4>Funding</h4>This research was supported by the Department of Energy (DOE), Office of Science, Biological and Environmental Research, as part of the Environmental System Science program, using data developed in the COMPASS-FME project and the River Corridors Science Focus Area at Pacific Northwest National Laboratory. PNNL is operated for the DOE by Battelle Memorial Institute.

An R Package for NMR Data Processing

The team of Professor&nbsp;<a target="_blank" rel="noopener noreferrer" href="https://hocek.group.uochb.cz/en">Michal Hocek</a> at IOCB Prague explores the limits of the structure and function of DNA and successfully pushes forward known boundaries. An article presenting the results of their latest research has just been published in the major scientific journal Nucleic Acids Research. They prove that even heavily modified double helices of DNA are stable enough to be used for special applications. This discovery might expand the possibilities of utilizing modified DNA, for example, in medicine.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/UOCHB_Tomas_Bellon_Scientists_from_IOCB_Prague_are_pushing_the_limits_of_DNA_b5c448f9a9.jpg" alt="ÚOCHB: Scientists from IOCB Prague are pushing the limits of DNA." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_UOCHB_Tomas_Bellon_Scientists_from_IOCB_Prague_are_pushing_the_limits_of_DNA_b5c448f9a9.jpg 245w," sizes="100vw" width="1910" height="1000">DNA consists of two long negatively charged chains that hold together even though they repel each other. This is made possible by what is known as stacking interactions and base pairing. Michal Hocek and his colleagues advanced the known limits when they modified DNA by adding an extra negative charge to each letter of the genetic code. This doubled the repulsive forces, yet the DNA double helix remained stable. They also found that such modified DNA not only holds together but that it can also be synthesized or replicated and sequenced using the enzyme DNA polymerase."Think of DNA as a scaffold on which you can attach various chemical compounds with different functions. These are small molecules, such as side chains of amino acids, which occur naturally only in peptides and proteins. In current medicine, we are able to use these molecules only to a relatively limited extent. The reason is that they are markedly unstable and get decomposed rapidly when inside an organism. One solution to this would be a stable skeleton to which they could be firmly attached. And DNA could be just such a base structure in the future," says Prof. Michal Hocek.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/UOCHB_Tomas_Bellon_Scientists_from_IOCB_Prague_are_pushing_the_limits_of_DNA_Prof_Michal_Hocek_Distinguished_Chair_and_head_of_Bioorganic_and_Medicinal_Chemistry_of_Nucleic_Acids_0a8c924ac4.jpg" alt="ÚOCHB / Tomáš Belloň: Prof. Michal Hocek, Distinguished Chair and head of Bioorganic and Medicinal Chemistry of Nucleic Acids." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_UOCHB_Tomas_Bellon_Scientists_from_IOCB_Prague_are_pushing_the_limits_of_DNA_Prof_Michal_Hocek_Distinguished_Chair_and_head_of_Bioorganic_and_Medicinal_Chemistry_of_Nucleic_Acids_0a8c924ac4.jpg 234w," sizes="100vw" width="1500" height="1001">The aim of this research carried out at IOCB Prague is to create DNA molecules that will mimic other chemical compounds. This would enable us to leverage the medicinal potential of certain biomolecules that are difficult to retain in the body. Examples of such biomolecules are the already mentioned peptides or proteins.The Hocek group has already made significant progress, although research in this direction is at its beginning worldwide. The team has, for example, succeeded at developing a novel modified aptamer, which is a short DNA sequence that can bind to a specific target molecule, most frequently a protein. Aptamers have similar properties to antibodies, but they are much more stable. For this reason, aptamers can potentially replace antibodies employed in medicine. However, the number of approved therapeutic aptamers globally can still be counted on the fingers of one hand.The current research exploring the limits of DNA is part of a larger project led by Michal Hocek, for which he has secured a prestigious EXPRO grant from the Czech Science Foundation. This is the second time its results have drawn interest from the journal Nucleic Acids Research. Previously, scientists from IOCB Prague published a method for the enzymatic synthesis of fully artificial DNA. During this synthesis, all nucleotides forming natural DNA are replaced by their modified versions with attached hydrophobic (i.e. water-repelling) molecules.

Scientists from IOCB Prague are pushing the limits of DNA

Article

Application

Poster

Scientific article

Science and research

Video

The Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences (IOCB Prague) is a leading scientific institution in the Czech Republic, recognized internationally. Its primary mission is basic research in the fields of chemical biology and medicinal chemistry, organic and material oriented chemistry, chemistry of natural compounds, biochemistry and molecular biology, physical chemistry, theoretical chemistry, and analytical chemistry. 

Ústav organické chemie a biochemie AV ČR

Everything from the world of analytical chemistry in one place. We connect people in solving their problems. At Labrulez you will find all the necessary information easily, quickly and clearly. Stop searching and start finding.

LabRulez

Pacific Northwest National Laboratory advances the frontiers of knowledge, taking on some of the world’s greatest science and technology challenges. PNNL is a U.S. Department of Energy national lab with distinctive strengths in chemistry, Earth sciences, biology, and data science that are central to our scientific discovery mission. PNNL’s research lays a foundation for innovations that advance sustainable energy through decarbonization and energy storage and enhance national security through nuclear materials and threat analyses. PNNL collaborates with academia in its fundamental research and with industry to transition technologies to market.

Pacific Northwest National Laboratory

Watrex xTrovert FLEX-O automation SPE sample preparation system

FLEX-O robotic system enabling automation sample preparation on solid phase using 96-titre plates.

FLEX-O robotic system enabling automation sample preparation on solid phase using 96-titre plates. Although there are solutions for automatic SPE on classic column formats, robotic system for automation in 96-well SPE plates is not currently on the market.In addition to the 8-channel pipetting head, the robot is equipped with a gripper and a filling dispenser, which applies wash solutions to the SPE positions on the plate. Instead of filtering using classic vacuum pump, which is used for manual SPE on columns or 96plates, the xTrovert FLEX-O system uses the so-called positive pressure technology when it is the reagent is pushed through the SPE membrane with a multi-channel pressure attachment. That’s it ensuring flow uniformity and reproducibility between individual samples on the plate.The robot is capable of processing up to 4 x 96-well sample plates (384 of total samples) using a protocol with up to 8 different washing and extraction reagents.The system is compatible with the Waters OligoWorks™ SPE Macroplate (96-well), Waters Oasis™ PRiME HLB, Macherey-Nagel™ SPE MULTI 96-Monoblock CHROMABOND™ and other 96-plate format SPE systems.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Watrex_x_Trovert_FLEX_O_automation_SPE_sample_preparation_system_ec3768960e.jpg" alt="Watrex xTrovert FLEX-O automation SPE sample preparation system.jpg" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Watrex_x_Trovert_FLEX_O_automation_SPE_sample_preparation_system_ec3768960e.jpg 208w," sizes="100vw" width="1433" height="1075">If necessary, the user can make modifications to the log using a simple scripting language and subsequent wireless upload to the device. Userthe interface for controlling the system is based on the integrated computer Raspberry Pi ® s 800×480 RGB LCD multi-touch touch screen and the possibility of remote wifi accessfrom an external device (e.g. mobile phone or tablet).<h4>Application</h4><ul><li>Purification of oligonucleotide synthesis products</li><li>Organic Synthesis</li><li>Environmental Analysis</li><li>Medical diagnostics</li><li>Molecular biology and biochemistry</li></ul>The entire system was designed and developed by Watrex Praha and is manufactured in the Czech Republic and promises a shift in the performance and efficiency of laboratory processes worldwide!

Products focused on Sample Preparation | LabRulez ICPMS

Related content

Scientists from IOCB Prague are pushing the limits of DNA

An R Package for NMR Data Processing

News from LabRulezICPMS Library - Week 40, 2024