<div><div>Researchers led by <a target="_blank" rel="noopener noreferrer" href="https://kudova.group.uochb.cz/en">Eva Kudová</a> from IOCB Prague and Jitka Viktorová from UCT Prague have identified new androstane-based steroid derivatives that can significantly improve the effectiveness of existing antibiotics against multidrug-resistant Staphylococcus aureus.</div></div><div>The team screened dozens of natural steroidal hormones and synthetic derivatives to see whether they could block bacterial efflux pumps – mechanisms that bacteria use to eject antibiotics and survive treatment. Two compounds emerged as particularly promising: they inhibited efflux pumps and lowered the effective doses of antibiotics such as ciprofloxacin and erythromycin.Further analysis showed that one of the compounds also suppressed genes linked to bacterial virulence. Another key finding is that the most active molecules are non-toxic to human immune cells and showed no detectable endocrine activity, suggesting a favorable safety profile.These findings support the idea that rationally designed steroid-based molecules could act as antibiotic adjuvants, helping existing drugs overcome bacterial resistance.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/IOCB_Prague_Steroidal_hormones_and_neurosteroids_novel_therapeutic_strategies_in_bacterial_infections_8e5d2a7b48.jpg" alt="IOCB Prague: Steroidal hormones and neurosteroids – novel therapeutic strategies in bacterial infections" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_IOCB_Prague_Steroidal_hormones_and_neurosteroids_novel_therapeutic_strategies_in_bacterial_infections_8e5d2a7b48.jpg 222w," sizes="100vw" width="1258" height="886"><blockquote><h4>Original Article</h4><h4><a target="_blank" rel="noopener noreferrer" href="https://www.sciencedirect.com/science/article/pii/S0223523426001613?via%3Dihub">Steroidal hormones and neurosteroids - novel therapeutic strategies in bacterial infections: Design, synthesis, and biological evaluation</a></h4>Daniela Brdová, Bára Křížkovská, Jan Špaček, Zdeněk Míchal, Eva Jablonská, Ondřej Strnad, Hana Chodounská, Eszter Szánti-Pintér, Marina Morozovová, Václav Hanžl, Jan Tkadlec, Martijn Riool, Jan Lipov, Jitka Viktorová, Eva Kudová&nbsp;Eur. J. Med. Chem., 2026, 308, 118716<a target="_blank" rel="noopener noreferrer" href="https://doi.org/10.1016/j.ejmech.2026.118716">https://doi.org/10.1016/j.ejmech.2026.118716</a><h6>licensed under <a target="_blank" rel="noopener noreferrer" href="https://creativecommons.org/licenses/by/4.0/">CC-BY 4.0</a></h6></blockquote><h4>Abstract</h4>The global rise of antibiotic resistance necessitates novel therapeutic strategies for infectious diseases. Inhibition of bacterial efflux pumps, which contribute to multidrug resistance, represents a promising approach to restore or even increase the efficacy of existing antibiotics. Using fluorescence-based ethidium bromide accumulation, broth microdilution, and checkerboard assays, we evaluated 26 endogenous steroidal hormones and neurosteroids, along with 30 synthetic derivatives, for their ability to enhance antibiotic susceptibility in multidrug-resistant Staphylococcus aureus. Structure-activity relationship analysis identified compounds 13 and 16 as lead candidates, exhibiting strong efflux pump inhibition and marked reductions in the minimum inhibitory concentrations of ciprofloxacin and erythromycin. Both compounds showed additive effects in checkerboard assays. Modifications at C-3 (polar substitution) and C-17 (3α,5β-stereochemistry and nonpolar substitution) were essential for potent efflux inhibition and sensitization, although these modifications were not additive when combined. Transcriptome analysis further revealed that compound 13 significantly downregulated S. aureus virulence-associated genes when administered alone or in combination with antibiotics. Cytotoxicity assessment in human peripheral blood mononuclear cells and receptor transactivation assays for estrogen, androgen, and progesterone receptors indicated that the most active derivatives were non-toxic and lacked detectable endocrine activity, suggesting a favorable safety profile. Overall, these findings support the concept that rationally designed andostane-based steroidal scaffolds can function as competitive bacterial efflux pump inhibitors and serve as potential antibiotic adjuvants to mitigate efflux-mediated resistance.<h4>Instrumentation</h4><h5>Structural characterization</h5><ul><li>AVANCE III 400 MHz NMR spectrometer (Bruker)</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/library?mainauthorItems=3&amp;search=LTQ+Orbitrap+XL">LTQ Orbitrap XL HRMS</a> (Thermo Fisher Scientific, ESI)</li></ul></div>

Steroidal hormones and neurosteroids – novel therapeutic strategies in bacterial infections

Wiley, a global leader in authoritative content and research intelligence for the advancement of scientific discovery, innovation and learning, today announced the release of additional data to its IR and Raman spectral libraries, significantly broadening compound coverage, including materials, polymers, minerals, and others.This latest release includes the first installment of Raman spectra from Wiley's collaboration with the American Museum of Natural History (AMNH), announced earlier this spring, drawing from one of the world's most important mineral collections.“Researchers depend on reference data as a foundation for sound scientific decisions,” said Graeme Whitley, senior director, data science solutions at Wiley. “Continuous updates ensure scientists always have the most current, reliable reference libraries at their fingertips, helping them work faster and make confident decisions when it matters most.”<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Wiley_Wiley_expands_its_trusted_IR_and_Raman_spectral_library_collections_helping_analytical_labs_make_faster_more_confident_decisions_1a54aaad3a.jpg" alt="Wiley: Wiley expands its trusted IR and Raman spectral library collections—helping analytical labs make faster, more confident decisions" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Wiley_Wiley_expands_its_trusted_IR_and_Raman_spectral_library_collections_helping_analytical_labs_make_faster_more_confident_decisions_1a54aaad3a.jpg 245w," sizes="100vw" width="1600" height="856"><h4>Summary of updates:</h4><h5>KnowItAll Raman Spectral Library Collection</h5><ul><li>Added: 1,213 spectra</li><li>Now contains: 29K+ spectra</li></ul>2 new databases:<ul><li>Raman – American Museum of Natural History Minerals – Wiley – 198 spectra</li><li>Raman – Microbiology – 71 spectra</li></ul>Spectra added to databases:<ul><li>Raman – Consumer Goods &amp; Food-Related Compounds – +104</li><li>Raman – Drugs – +128</li><li>Raman – Materials – +132</li><li>Raman – Minerals – +233</li><li>Raman – Polymers – +5</li><li>Raman – Pigments &amp; Dyes – +342</li></ul><h5>KnowItAll IR Spectral Library Collection</h5><ul><li>Added: 949 spectra</li><li>Now contains: 344K+ spectra</li></ul>7 new databases:<ul><li>ATR-IR – Clinical – 364 spectra</li><li>ATR-IR – Materials – 10 spectra</li><li>ATR-IR – Pigments &amp; Dyes – 420 spectra</li><li>ATR-IR – Polymers – 21 spectra</li><li>IR – Clinical – 20 spectra</li><li>IR – Materials – 17 spectra</li><li>IR – Microbiology – 75 spectra</li></ul>Spectra added to databases:<ul><li>IR – Minerals – +5</li><li>IR – Polymers – +17</li></ul>Spectral library subscribers automatically gain access to new data, ensuring labs always have the most current, reliable reference libraries to improve analysis, reduce errors, and increase productivity.<ul><li>Learn more at: <a target="_blank" rel="noopener noreferrer" href="https://sciencesolutions.wiley.com/spectral-databases/">www.sciencesolutions.wiley.com/spectral-databases</a></li><li>Existing subscribers can access step-by-step guidance on updating their KnowItAll databases at <a target="_blank" rel="noopener noreferrer" href="https://sciencesolutions.wiley.com/how-to-update-knowitall-databases">https://sciencesolutions.wiley.com/how-to-update-knowitall-databases</a></li></ul><h5>Wiley Spectral Databases</h5>Wiley's spectral databases are consistently evolving to meet today's research demands, covering multiple spectral techniques across a wide range of applications including polymers, materials, environmental, forensics, toxicology, pharmaceutical, biotech, automotive, aerospace, food, cosmetics, and more. Built on rigorous quality protocols, Wiley delivers industry-leading spectral data and intelligent tools to accelerate analysis and deliver deeper insights — making it the authoritative, trusted source that analytical labs worldwide rely on.&nbsp;<h5>About Wiley</h5>Wiley (NYSE: WLY) is a global leader in authoritative content and research intelligence for the advancement of scientific discovery, innovation, and learning. With more than 200 years at the center of the scholarly ecosystem, Wiley combines trusted publishing heritage with AI-powered platforms to transform how knowledge is discovered, accessed, and applied. From individual researchers and students to Fortune 500 R&amp;D teams, Wiley enables the transformation of scientific breakthroughs into real-world impact. From knowledge to impact—Wiley is redefining what's possible in science and learning.&nbsp;

Wiley expands its trusted IR and Raman spectral library collections

Our Library never stops expanding. What are the most recent contributions to LabRulezICPMS Library in the week of 4th May 2026? Check out new documents from the field of spectroscopy/spectrometry and related techniques!<blockquote>👉 <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/library">SEARCH THE LARGEST REPOSITORY OF DOCUMENTS ABOUT SPECTROSCOPY/SPECTROMETRY RELATED TECHNIQUES</a></blockquote><blockquote>👉 Need info about different analytical techniques? Peek into <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/library">LabRulezLCMS</a> or <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library">LabRulezGCMS</a> libraries.</blockquote>This week we bring you application notes by KNAUER, Shimadzu, and Thermo Fisher Scientific!<h3>1. KNAUER: Analysis of HPLC fractions by Benchtop NMR</h3><ul><li>Application note</li><li><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/labrulez-bucket-strapi-h3hsga3/knauer_hplc_benchtop_nmr_web_638c60e13c.pdf">Full PDF for download</a></li></ul>Preparative HPLC is essential for isolating compounds and removing impurities in pharmaceutical and chemical industries. Non-destructive, fast analysis is preferred to maintain yield and enable at-line monitoring, avoiding lengthy sample preparation. Recent advancements in benchtop NMR spectrometers (up to 90 MHz) allow quick analysis without deuterated solvents. In this proof-of-concept study we purified a pharmaceutical sample via HPLC and confirmed its identity using benchtop NMR. Fractions (0.7–4.4 mM) were analyzed without preparation, using only 300 µL per sample, ensuring rapid batch control with no product loss. This study demonstrates the seamless integration of HPLC and benchtop NMR.<h4>Experimental</h4><h5>Preparative HPLC Method</h5>Eluent 20:80 Ethanol/water, isocratic mode, flow rate 12.5 ml/min, detection UV254 nm 2 Hz, 500 µl stacked injection, automated fractionation with threshold function, column temperature ambient, Column Eurospher II 100-10 C18 150x20 mm&nbsp;<h5>Analytical HPLC Method</h5>Eluent 20:80 Ethanol /water + 0.1% formic acid, isocratic mode, flow rate 1 ml/min, detection UV254 nm 10 Hz, 5 µl partial loop injection, column temperature 25 °C, Column <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/1633">Eurospher II 100-5 C18</a> 150x4 mm&nbsp;<h5>NMR Method&nbsp;</h5>NMR spectra were acquired on a Magritek Multi-X Ultra 80 MHz benchtop NMR system using an adapted WET sequence for solvent suppression. 32 scans were acquired with a repetition time of 15s. WET parameters were adjusted for each sample to yield optimal suppression for all solvent signals. Pooled HPLC fractions were analysed directly without addition of deuterated solvents or other sample preparation.<h4>Conclusion</h4>This proof-of-concept study successfully shows that HPLC and benchtop NMR can be used together easily. Samples can be analyzed non-destructively within minutes and without any further preparation due to highly efficient suppression of multiple solvent signals. Compounds can be identified without the need of reference standards. This study shows that NMR can provide a valid compatible alternative detector for HPLC fraction analysis.<h3>2. Shimadzu: DIC Analysis in High-Speed Tensile Test of CFRP</h3><ul><li>Application note</li><li><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/labrulez-bucket-strapi-h3hsga3/an_01_00854_en_fb6c68b858.pdf">Full PDF for download</a></li></ul><h4>User Benefits</h4><ul><li>The <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/library?mainauthorItems=1&amp;search=HPV-X3">HPV-X3</a> is suitable for observation of fracture of brittle materials such as CFRP because it has a maximum recording speed (framerate) of 20 Mfps.&nbsp;</li><li>The HPV-X3 provides improved DIC analysis performance, as its resolution is 3 times higher than that of the conventional highspeed video camera.</li><li>The HITS-TX impact testing machine enables testing at a maximum speed of 20 m/s</li></ul>Carbon fiber reinforced plastic (CFRP) is a material with particularly high specific strength, even among composite materials, and used in various applications such as transport aircraft, taking advantage of its excellent mechanical properties. Because CFRP consists of carbon fibers and resin, it shows complex fracture behavior, and brittle fracture progresses from damage as the point of origin. Since fracture proceeds instantaneously, a high-speed video camera with a high recording speed is necessary when observing fracture of CFRP. One method for measuring strain in a high-speed tensile test is Digital Image Correlation (DIC), which visualizes the distribution of strain at the specimen surface by comparing a random pattern on the specimen surface before and after deformation. Thus, a high-speed video camera with a high resolution is also necessary in order to improve the DIC performance.&nbsp;Newly-developed <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/library?mainauthorItems=1&amp;search=HPV-X3">Hyper Vision HPV-X3 high-speed video camera</a> is extremely well-suited to DIC analysis of CFRP, as its recording speed is 2 timesfaster and itsresolution is 3 times higher than the conventional HPV-X2. In this experiment, a high-speed tensile test of CFRP was conducted using a HITS-TX high-speed tensile testing machine. The condition of the test was observed with the new HPV-X3, and the strain distribution of the CFRP test piece was clarified by a DIC analysis of the recorded images.<h4>Test Piece and Test Instruments</h4>A CFRP quasi-isotropic laminate was used as the test piece. Aluminum foil was glued to the back side of the test piece, and the timing when the electrical conduction of the aluminum foil was interrupted by fracture of the test piece was used as the trigger for video recording. The HITS-TX was used in the highspeed tensile test. The HPV-X3 was used in fracture observation, and for comparison, the fracture process was also recorded with the conventional HPV-X2 camera. Fig. 1 shows the condition of the test, and Table 1 and Table 2 show the equipment composition and test conditions, respectively.<h4>DIC Analysis Results in High-Speed Tensile Test</h4>Fig. 3 shows the DIC analysis results in the high-speed tensile test. The color bar was set to display the color purple at around 0 % strain and red at around 2 % strain. Fig. 3 (1) is an image at the start of the test. After the test started, strain in the 45˚ direction concentrated from the lower left to the right central area, as can be seen in Fig. 3 (2). Then, as the test progressed, a condition of increasing strain in the initial area of strain concentration can be seen in Fig. 3 (3) to (9). A crack occurs in Fig. 3 (10), and strain decreases in the crack area. Following this, the test piece fractured completely in Fig. 3 (11) and (12), and a decrease in the strain in the area around the crack could be observed.<h4>Conclusion</h4>A high-speed tensile test of CFRP was conducted using a HITSTX high-speed tensile testing machine and the newlydeveloped HPV-X3 high-speed video camera, and the strain distribution at the time of test piece fracture was visualized by a DIC analysis. Because the HPV-X3 offers a 3 times higher resolution and a 2 times faster recording speed than the conventional device, it is a suitable high-speed video camera for fracture observation and DIC analysis in impact tests of brittle materials such as CFRP. The measurement system introduced in this Application News article is a useful tool for the development of composite materials.<h3>3. Thermo Fisher Scientific: Polymer analysis using femtosecond-laser-ablation depth profiling</h3><ul><li>Application note</li><li><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/labrulez-bucket-strapi-h3hsga3/xps_depth_profiling_polymer_analysis_appnote_c731e2e7e0.pdf">Full PDF for download</a></li></ul>X-ray photoelectron spectroscopy (XPS) is an essential polymer characterization technique that can identify not just the elemental composition but also the chemical state of polymer samples. This allows the chemical bonding environment to be deduced and, as a result, the polymer species can be identified. This can all be achieved with minimal sample preparation thanks to the built-in charge-compensation systems found in XPS instruments, which simplify the analysis of insulating samples.&nbsp;The introduction of gas cluster ion sources (GCIS), such as the Thermo Scientific™ MAGCIS Dual Mode Ion Source, marked a major step forward in polymer analysis. Unlike monatomic ion beams, GCIS are able to clean surface contamination, and etch away layers of sample material, without damaging the underlying chemistry of organic samples such as polymers. As a result, GCIS has allowed chemical-damage-free analysis to reach micrometers below the sample surface. This depth of analysis can be highly time consuming, however, and total experimental times can range from multiple hours to days.&nbsp;The addition of femtosecond-laser-ablation (fs-LA) technology is alleviating this, allowing for XPS spectra to be collected from a depth of tens of µm into a sample in a matter of minutes. This is because the laser ablation occurs on the femtosecond timescale (i.e., nearly instantaneously), effectively eliminating the material removal time of the depth profile. Additionally, unlike other material removal techniques such as atomic ion beam impact (where a collision cascade effect is induced to remove surface material) fs-LA is capable of removing material without chemical damage due to the ultrashort columbic explosion process used to eject the material. The resulting profile is therefore representative of the actual sample chemistry.<h4>Paint layer analysis&nbsp;</h4>In traditional ion-beam depth profiling, analytical depths are generally limited to several hundred nanometers, up to a micrometer. This means that it is extremely difficult to analyze the interfaces between multiple micrometer-thick layers in a sample without the use of additional techniques such as ultralow-angle microtome (ULAM) sectioning.¹ The introduction of fs-LA technology, however, allows micrometers of material to be removed rapidly, enabling the characterization of layered samples.&nbsp;As an example, a multi-layer paint specimen (provided by the University of Surrey, UK) was depth profiled using the <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/products/2206">Thermo Scientific™ Hypulse™ Surface Analysis System</a>. The sample consists of an aluminum substrate coated with a 5 µm layer of polyurethane primer followed by a 25 µm PMMA/PVdF topcoat.The depth profile was generated using a 1,030 nm laser with an energy of 250 µJ for ablation, along with a 30 µm X-ray spot size for data collection. XPS spectra were collected after each ablation cycle to obtain an atomic concentration plot through both paint layers into the substrate material (Figure 2).&nbsp;5 distinct regions throughout the analyzed depth can be seen. The top surface of the sample consists of an adventitious layer of carbon contamination, which is commonly found on samples exposed to air. The second layer is the 25 µm PVdF/PMMA topcoat, and the third layer is the PU primer. Between the primer and the final aluminum substrate layer, a clear increase in adventitious carbon is observed, similar to the signal seen at the top sample surface. This suggests residual carbon contamination was present on the substrate before the paint layers were applied.&nbsp;It would take hours to produce the XPS depth profile shown in Figure 2 using traditional ion beam approaches. Even with the use of a monatomic beam with a high energy per atom, the length of the analysis could still be just as long, depending on the sample material, and would sacrifice the chemistry of any organic/polymeric materials. The combination of fs-LA depth profiling and snapshot XPS acquisition, meanwhile, can reduce the experimental time to less than 20 minutes without inducing any chemical damage to the sample surface.<h4>Summary&nbsp;</h4>One of the most critical aspects of successful polymer XPS depth profiling is the preservation of the sample chemistry during material removal. Additionally, experiment time can be a significant limiting factor, and thicker samples could lead to reduced time for repeat experiments. The femtosecond laser ablation capabilities of the Hypulse Surface Analysis System provide fast, efficient, and chemical-damage-free material removal from a sample surface, enabling analysis multiple micrometers into a sample. This means that hidden sample interfaces, that were largely inaccessible before, can now be analyzed easily and efficiently

News from LabRulezICPMS Library - Week 19, 2026

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The Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences (IOCB Prague) is a leading scientific institution in the Czech Republic, recognized internationally. Its primary mission is basic research in the fields of chemical biology and medicinal chemistry, organic and material oriented chemistry, chemistry of natural compounds, biochemistry and molecular biology, physical chemistry, theoretical chemistry, and analytical chemistry. 

Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences

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Thermo Scientific iCE™ 3300 Atomic Absorption Spectrometer 

The Thermo Scientific™ iCE™ 3300 AAS provides a complete elemental analysis solution incorporating simplicity and an innovative design to achieve superior performance. 

The Thermo Scientific™ iCE™ 3300 AAS provides a complete elemental analysis solution incorporating simplicity and an innovative design to achieve superior performance. The iCE 3300 AAS makes even the most complicated analyses simple.The high precision, double beam optics provide unrivalled performance, unparalleled detection limits and exceptional optical stability. The innovative hardware design minimizes the footprint of the instrument and ensures that day-to-day analysis and maintenance is simple and minimal. Safety comes as standard with integrated hardware safety features and automatic MFC gas controls.<h3>Three Options to Suit your Laboratory's Needs</h3><h4>Dedicated Flame</h4>A single flame atomizer AAS with a fully automatic MFC gas box, the iCE 3300 AAS Flame system delivers a complete solution for laboratories with a primary requirement for flame analysis.<h4>Dedicated Furnace</h4>The cost effective iCE 3300 AAS Graphite Furnace system provides a complete solution for laboratories with a main need for elemental analysis by furnace.<h4>Dual Flame and Furnace</h4>Simply add the optional Thermo Scientific™ GFS33™ Graphite Furnace and Autosampler to your iCE 3300 AAS flame instrument to create a compact, interchangeable, multi atomizer and access the best of both worlds.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Pragolab_Thermo_Scientific_i_CE_3300_GF_Atomovy_absorpcni_spektrometr_5bcd29e1a5.jpg" alt="Thermo Scientific iCE™ 3300 Atomic Absorption Spectrometer " srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Pragolab_Thermo_Scientific_i_CE_3300_GF_Atomovy_absorpcni_spektrometr_5bcd29e1a5.jpg 159w," sizes="100vw" width="760" height="746"><h3>Maximize Productivity</h3><ul><li>Increase your sample through-put and limit downtime with productivity enhancing technology</li><li>Optimization routines can be included in the method to ensure truly optimal parameters</li><li>Thermo Scientific™ SOLAAR™ software offers ultimate ease-of-use with extensive help functions, automated performance controls and wizards</li><li>Self-calibrating monochromators and auto-aligning lamps offer simple optical setup and optimum light throughput in dedicated Flame system</li><li>Parts-per-billion ultra-trace detection capability from dedicated Graphite Furnace system</li></ul><h3>Gain Cost Efficiency</h3><ul><li>Gain even greater efficiency from hardware and accessories designed to maximize cost efficiency.</li><li>Fully automatic gas control system ensures repeatable flame conditions and safety</li><li>Configure the fully customizable auto-sampler to maximize through-put</li><li>Designed to ensure lowest possible gas flows to significantly reduce cost of consumables</li><li>Innovative Extended Lifetime Cuvettes (ELC) for reduced consumable costs, can be used for thousands of Graphite Furnace firings</li></ul><h3>Enjoy Advanced Performance</h3>Improve your analysis with high performing instruments the deliver accuracy and precision.<ul><li>Unbeatable Flame performance with superior detection limits and a fully inert sample system</li><li>Graphite Furnace obtains drift free results from automated cuvette heating control meaning, for accurate, repeatable analysis</li><li>Guaranteed Deuterium background correction for high accuracy</li><li>Flame option uses a universal finned titanium burner to enable the use of both air/acetylene and nitrous oxide/acetylene flame types and maintains a stable, reproducible flame</li><li>Graphite Furnace TV (GFTV) real time viewing enables precise analysis, time after time</li></ul><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Pragolab_Thermo_Scientific_i_CE_3000_series_Atomovy_absorpcni_spektrometr_3_89ef958fa2.jpg" alt="Thermo Scientific iCE™ 3300 Atomic Absorption Spectrometer " srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Pragolab_Thermo_Scientific_i_CE_3000_series_Atomovy_absorpcni_spektrometr_3_89ef958fa2.jpg 245w," sizes="100vw" width="1932" height="1086"><h3>iCE 3300 Series AAS Flame summary</h3><h4>General</h4><ul data-start="80" data-end="307"><li data-start="80" data-end="120">Number of sample compartments: 1</li><li data-start="121" data-end="144">PC control: Yes</li><li data-start="145" data-end="183">Software: Included as standard</li><li data-start="184" data-end="220">Lamp carousel: Auto aligning</li><li data-start="221" data-end="245">Lamp capacity: 6</li><li data-start="246" data-end="307">Lamp type: Coded and uncoded single and multi element</li></ul><h4>Optics</h4><ul data-start="324" data-end="599"><li data-start="324" data-end="352">Monochromator: Ebert</li><li data-start="353" data-end="401">Spectral bandwidths: 0.2, 0.5 and 1.0 nm</li><li data-start="402" data-end="459">Reciprocal linear dispersion: 2.0 nm/mm at 200 nm</li><li data-start="460" data-end="490">Grating: 1800 lines/mm</li><li data-start="491" data-end="524">Optical set up: Automatic</li><li data-start="525" data-end="561">Wavelength range: 180-900 nm</li><li data-start="562" data-end="599">Drift correction: Double beam</li></ul><h4>Flame features</h4><ul><li>Banner type: Choose 50 mm finned universal burner OR 100 mm burner</li><li>Gas box: MFC fully automatic</li><li>Flame background correction: Deuterium</li><li>Flame autosampler: Compatible with CETAC 280, CETAC 560</li></ul><h4>Options</h4><ul data-start="1133" data-end="1220" data-is-last-node="" data-is-only-node=""><li data-start="1133" data-end="1159">Vapor upgrade: Yes</li><li data-start="1160" data-end="1191">Validator packages: Yes</li><li data-start="1192" data-end="1220" data-is-last-node="">Security software: Yes</li></ul>

Thermo Scientific iCE™ 3300 Graphite Furnace Atomic Absorption Spectrometer (GF-AAS)

The Thermo Scientific™ iCE™ 3300 AAS provides a complete elemental analysis solution incorporating simplicity and an innovative design to achieve superior performance. The iCE 3300 AAS makes even the most complicated analyses simple.The high precision, double beam optics provide unrivalled performance, unparalleled detection limits and exceptional optical stability. The innovative hardware design minimizes the footprint of the instrument and ensures that day-to-day analysis and maintenance is simple and minimal. Safety comes as standard with integrated hardware safety features and automatic MFC gas controls.<h3>Three Options to Suit your Laboratory's Needs</h3><h4>Dedicated Furnace</h4>The cost effective iCE 3300 AAS Graphite Furnace system provides a complete solution for laboratories with a main need for elemental analysis by furnace.<h4>Dedicated Flame</h4>A single flame atomizer AAS with a fully automatic MFC gas box, the iCE 3300 AAS Flame system delivers a complete solution for laboratories with a primary requirement for flame analysis.<h4>Dual Flame and Furnace</h4>Simply add the optional Thermo Scientific™ GFS33™ Graphite Furnace and Autosampler to your iCE 3300 AAS flame instrument to create a compact, interchangeable, multi atomizer and access the best of both worlds.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Pragolab_Thermo_Scientific_i_CE_3300_GF_Atomovy_absorpcni_spektrometr_5bcd29e1a5.jpg" alt="Thermo Scientific iCE™ 3300 GF Atomic Absorption Spectrometer (GF-AAS)" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Pragolab_Thermo_Scientific_i_CE_3300_GF_Atomovy_absorpcni_spektrometr_5bcd29e1a5.jpg 159w," sizes="100vw" width="760" height="746"><h3>Maximize Productivity</h3><ul><li>Increase your sample through-put and limit downtime with productivity enhancing technology</li><li>Optimization routines can be included in the method to ensure truly optimal parameters</li><li>Thermo Scientific™ SOLAAR™ software offers ultimate ease-of-use with extensive help functions, automated performance controls and wizards</li><li>Self-calibrating monochromators and auto-aligning lamps offer simple optical setup and optimum light throughput in dedicated Flame system</li><li>Parts-per-billion ultra-trace detection capability from dedicated Graphite Furnace system</li></ul><h3>Gain Cost Efficiency</h3><ul><li>Gain even greater efficiency from hardware and accessories designed to maximize cost efficiency.</li><li>Fully automatic gas control system ensures repeatable flame conditions and safety</li><li>Configure the fully customizable auto-sampler to maximize through-put</li><li>Designed to ensure lowest possible gas flows to significantly reduce cost of consumables</li><li>Innovative Extended Lifetime Cuvettes (ELC) for reduced consumable costs, can be used for thousands of Graphite Furnace firings</li></ul><h3>Enjoy Advanced Performance</h3>Improve your analysis with high performing instruments the deliver accuracy and precision.<ul><li>Unbeatable Flame performance with superior detection limits and a fully inert sample system</li><li>Graphite Furnace obtains drift free results from automated cuvette heating control meaning, for accurate, repeatable analysis</li><li>Guaranteed Deuterium background correction for high accuracy</li><li>Flame option uses a universal finned titanium burner to enable the use of both air/acetylene and nitrous oxide/acetylene flame types and maintains a stable, reproducible flame</li><li>Graphite Furnace TV (GFTV) real time viewing enables precise analysis, time after time</li></ul><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Pragolab_Thermo_Scientific_i_CE_3000_series_Atomovy_absorpcni_spektrometr_3_89ef958fa2.jpg" alt="Thermo Scientific iCE™ 3300 GF Atomic Absorption Spectrometer (GF-AAS)" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Pragolab_Thermo_Scientific_i_CE_3000_series_Atomovy_absorpcni_spektrometr_3_89ef958fa2.jpg 245w," sizes="100vw" width="1932" height="1086"><h3>iCE 3300 Series AAS Furnace summary</h3><h4>General</h4><ul data-start="80" data-end="307"><li data-start="80" data-end="120">Number of sample compartments: 1</li><li data-start="121" data-end="144">PC control: Yes</li><li data-start="145" data-end="183">Software: Included as standard</li><li data-start="184" data-end="220">Lamp carousel: Auto aligning</li><li data-start="221" data-end="245">Lamp capacity: 6</li><li data-start="246" data-end="307">Lamp type: Coded and uncoded single and multi element</li></ul><h4>Optics</h4><ul data-start="324" data-end="599"><li data-start="324" data-end="352">Monochromator: Ebert</li><li data-start="353" data-end="401">Spectral bandwidths: 0.2, 0.5 and 1.0 nm</li><li data-start="402" data-end="459">Reciprocal linear dispersion: 2.0 nm/mm at 200 nm</li><li data-start="460" data-end="490">Grating: 1800 lines/mm</li><li data-start="491" data-end="524">Optical set up: Automatic</li><li data-start="525" data-end="561">Wavelength range: 180-900 nm</li><li data-start="562" data-end="599">Drift correction: Double beam</li></ul><h4>Furnace features</h4><ul data-start="873" data-end="1115"><li data-start="873" data-end="901">Furnace model: GFS33</li><li data-start="902" data-end="951">Furnace vision system (GFTV): As standard</li><li data-start="952" data-end="1000">Furnace background correction: Deuterium</li><li data-start="1001" data-end="1051">Automatic flame to furnace change over: No</li><li data-start="1052" data-end="1115">Cuvettes: Normal, coated, extended life (ELC), platform</li></ul><h4>Options</h4><ul data-start="1133" data-end="1220" data-is-last-node="" data-is-only-node=""><li data-start="1133" data-end="1159">Vapor upgrade: Yes</li><li data-start="1160" data-end="1191">Validator packages: Yes</li><li data-start="1192" data-end="1220" data-is-last-node="">Security software: Yes</li></ul>

Thermo Scientific™ iCE™ 3400 Graphite Furnace AAS

If your laboratory routinely requires ultra-sensitive detection limits from furnace analysis, the Thermo Scientific™ iCE™ 3400 AAS is ideal. 

If your laboratory routinely requires ultra-sensitive detection limits from furnace analysis, the Thermo Scientific™ iCE™ 3400 AAS is ideal. This dedicated single Graphite Furnace AAS with both Deuterium and Zeeman background correction offers superb performance and value for money.Renowned Thermo Scientific™ SOLAAR™ software provides ultimate ease of use and analysis optimization; while our innovative Graphite Furnace Television (GFTV) gives a real time view of the cuvette as an aid to method development, ensuring accurate repeatable analysis.<h3>Maximize Productivity</h3>This low cost Graphite Furnace AAS system, delivers a complete solution for laboratories facing challenging detection limits and needing elemental analysis by furnace.<ul><li>Dedicated furnace with parts-per-billion ultra-trace detection capability</li><li>Six lamp auto-aligning carousel to maximize light through-put</li><li>Run unattended, automated analysis with fully configurable auto-sampler</li><li>SOLAAR software provides incredible support with wizards, optimization routines and automated performance controls</li></ul><h3>Gain Cost Efficiency</h3>Gain even greater efficiency from hardware and accessories designed with cost control in mind.<ul><li>Innovative Extended Lifetime Cuvettes (ELC) for reduced consumable costs, can be used for thousands of firings</li><li>Run analysis with just micro-liters of sample to minimize consumable consumption</li><li>Gas flows with intelligent software controls keep usage low</li><li>GFTV real time viewing enables precise analysis, time after time</li></ul><h3>Enjoy Advanced Performance and Flexibility</h3>All the innovation, performance and ease of use you expect from Thermo Scientific instruments come as standard with the iCE 3400 AAS.<ul><li>Guaranteed Deuterium and Zeeman background correction for high accuracy</li><li>Vapour system and electrically heated cell can be utilised in this model</li><li>Drift free results from automated cuvette heating control meaning, for accurate, repeatable analysis</li><li>Advanced Echelle optical system for precise measurements</li></ul>

Thermo Scientific™ iCE™ 3500 AAS Atomic Absorption Spectrometer

The Thermo Scientific™ iCE™ 3500 AAS delivers high performance, flexibility, and easy use with a dual atomizer enabling safe, software-controlled flame-to-furnace switching via a single mirror movement.

The Thermo Scientific™ iCE™ 3500 AAS provides unrivalled performance, flexibility and simplicity. The innovative dual atomizer design enables safe, software-controlled switching between flame and furnace analysis with a single mirror movement. The high precision, double beam optics, combined with an Echelle monochromator produce low detection limits and long term analytical stability. Unique Quadline deuterium background correction with guaranteed performance is provided as standard.The flame atomizer design incorporates a 50 mm titanium burner with improved solids capability to increase the efficiency and accuracy of your flame analysis.The furnace atomizer includes GFTV, a furnace vision system which improves efficiency and simplifies method development by providing a high definition, real time video of the inside of the cuvette.<h3>Maximize Productivity</h3>This combined Flame and Furnace AAS system, delivers a complete solution for laboratories facing challenging detection limits and needing high through-put sample capacity.<ul><li>Software-controlled changeover from flame to furnace analysis, without an operator even in the room</li><li>Run unattended, automated analysis with fully configurable auto-sampler</li><li>SOLAAR software provides incredible support with wizards, optimization routines and automated performance controls</li><li>Six lamp auto-aligning carousel for maximum light throughput</li></ul><h3>Gain Cost Efficiency</h3>Gain even greater efficiency from hardware and accessories designed for cost efficiency.<ul><li>Innovative Extended Lifetime Cuvettes (ELC) for reduced consumable costs, can be used for thousands of firings</li><li>Run analysis with just micro-liters of sample to minimize consumable consumption</li><li>Gas flows with intelligent software controls keep gas usage to a minimum</li><li>GFTV real time viewing enables precise analysis, time after time</li></ul><h3>Enjoy Advanced Performance and Flexibility</h3>All the innovation, performance and ease of use you expect from Thermo Scientific instruments come with the iCE3500 AAS.<ul><li>The unique dual atomizer design provides a second sample compartment where the furnace can be left permanently aligned and ready for use</li><li>D2 background correction for flame and furnace analysis as standard</li><li>Zeeman background correction available for furnace work, from the optional Thermo Scientific™ GFS35Z™ furnace upgrade</li><li>Double beam optics with a dual monochromators consisting of an Echelle prism and a grating</li></ul><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Pragolab_Thermo_Scientific_i_CE_3500_Atomovy_absorpcni_spektrometr_0cb19a2719.jpg" alt="Thermo Scientific™ iCE™ 3500 AAS Atomic Absorption Spectrometer" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Pragolab_Thermo_Scientific_i_CE_3500_Atomovy_absorpcni_spektrometr_0cb19a2719.jpg 160w," sizes="100vw" width="782" height="764"><h3>iCE™ 3500 Series AAS summary</h3><h4>General</h4><ul data-start="80" data-end="307"><li data-start="80" data-end="120">Number of sample compartments: 2</li><li data-start="121" data-end="144">PC control: Yes</li><li data-start="145" data-end="183">Software: Included as standard</li><li data-start="184" data-end="220">Lamp carousel: Auto aligning</li><li data-start="221" data-end="245">Lamp capacity: 6</li><li data-start="246" data-end="307">Lamp type: Coded and uncoded single and multi element</li></ul><h4>Optics</h4><ul data-start="324" data-end="619"><li data-start="324" data-end="354">Monochromator: Echelle</li><li data-start="355" data-end="423">Spectral bandwidths: 0.1 (below 400 nm), 0.2, 0.5 and 1.0 nm</li><li data-start="424" data-end="481">Reciprocal linear dispersion: 0.5 nm/mm at 200 nm</li><li data-start="482" data-end="510">Grating: 2D Spectrum</li><li data-start="511" data-end="544">Optical set up: Automatic</li><li data-start="545" data-end="581">Wavelength range: 180-900 nm</li><li data-start="582" data-end="619">Drift correction: Double beam</li></ul><h4>Flame features</h4><ul data-start="644" data-end="866"><li data-start="644" data-end="718">Banner type: Choose 50 mm finned universal burner OR 100 mm burner</li><li data-start="719" data-end="755">Gas box: MFC fully automatic</li><li data-start="756" data-end="802">Flame background correction: Deuterium</li><li data-start="803" data-end="866">Flame autosampler: Compatible with CETAC 280, CETAC 560</li></ul><h4>Furnace features</h4><ul data-start="893" data-end="1146"><li data-start="893" data-end="931">Furnace model: GFS35 or GFS35Z</li><li data-start="932" data-end="981">Furnace vision system (GFTV): As standard</li><li data-start="982" data-end="1030">Furnace background correction: Deuterium</li><li data-start="1031" data-end="1082">Automatic flame to furnace change over: Yes</li><li data-start="1083" data-end="1146">Cuvettes: Normal, coated, extended life (ELC), platform</li></ul><h4>Options</h4><ul data-start="1164" data-end="1253"><li data-start="1164" data-end="1190">Vapor upgrade: Yes</li><li data-start="1191" data-end="1222">Validator packages: Yes</li><li data-start="1223" data-end="1253">Security software: Yes</li></ul>

Products from category AAS - page 1

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