<h3><strong>Conference Program</strong></h3>
<h3><strong>13th October 2021 (Wednesday)</strong></h3>
<h5><strong>7:30 - 8:20 REGISTRATION</strong></h5>
<h5><strong>8:20 - 8:40 OPENING OF THE CONFERENCE</strong></h5>
<h4><strong>SESSION I (in NLT)</strong></h4>
<p>(Chair: František Tureček (University of Washington, United States))</p>
<h5><strong>8:40 - 9:30 Computational and Gas-phase Studies in Service of Catalysis Research: Identification of the &quot;Aristocratic Atoms&quot;</strong></h5>
<ul>
<li><em>Helmut Schwarz (Technische Universität Berlin, Germany)</em><h5><strong>9:30 - 10:00 Mass Spectrometry at the J. Heyrovský Institute of Physical Chemistry</strong></h5>
</li>
<li><em>Miroslav Polášek (Heyrovský Institute of Physical Chemistry of the CAS, Czech Republic)</em><h5><strong>10:00 - 10:30 Gas Phase Ion-molecule Reactions in Czechia over 60 Years</strong></h5>
</li>
<li><em>Patrik Španěl (Heyrovský Institute of Physical Chemistry of the CAS, Czech Republic)</em></li>
</ul>
<h5><strong>COFFEE BREAK</strong></h5>
<h4><strong>SESSION II (in NLT)</strong></h4>
<p>(Chair: <a href="https://lcms.cz/articles?search=michal+holcapek">Michal Holčapek</a> (<a href="https://lcms.cz/companies/15">University of Pardubice</a>, Czech Republic))</p>
<h5><strong>11:00 - 11:30 Past, Present and Future of Orbitrap Mass Spectrometry (virtual presentation)</strong></h5>
<ul>
<li><em>Alexander Makarov (Thermo Fisher Scientific, Germany)</em></li>
</ul>
<h5><strong>11:30 - 12:00 Development of Novel Ion-less Matrices for Profiling and Imaging Mass Spectrometry</strong></h5>
<ul>
<li><em>Aleš Svatoš (Max Planck Institute for Chemical Ecology, Germany)</em></li>
</ul>
<h5><strong>12:00 - 12:30 Mass Spectrometry at the Institute of Organic Chemistry and Biochemistry &amp; Museum Opening</strong></h5>
<ul>
<li><em>Josef Cvačka (Institute of Organic Chemistry and Biochemistry of the CAS, Czech Republic)</em></li>
</ul>
<h5><strong>LUNCH BREAK</strong></h5>
<h4><strong>SESSION III (in NLT)</strong></h4>
<p>(Chair: Miroslav Polášek (Heyrovský Inst. of Physical Chemistry of the <a href="https://lcms.cz/companies/10">CAS</a>, Czech Republic))</p>
<h5><strong>14:00 - 14:50 High-resolution Native Mass Spectrometry</strong></h5>
<ul>
<li><em>Albert J. R. Heck (Utrecht University, The Netherlands)</em></li>
</ul>
<h5><strong>14:50 - 15:20 Noncanonical Ionized DNA Nucleobases and Nucleosides. A Dark Matter of DNA Ionization?</strong></h5>
<ul>
<li><em>František Tureček (University of Washington, United States)</em></li>
</ul>
<h5><strong>15:20 - 15:50 Mass Spectrometry at the University of Pardubice: Focus on Lipidomics</strong></h5>
<ul>
<li><em>Michal Holčapek (University of Pardubice, Czech Republic)</em></li>
</ul>
<h5><strong>15:50 - 16:20 Forty Year Evolution of High Throughput Mass Spectrometry: A Perspective (virtual presentation)</strong></h5>
<ul>
<li><em>Tom Covey (SCIEX, Canada)</em></li>
</ul>
<h5><strong>BREAK</strong></h5>
<h4><strong>POSTER SESSION &amp; DINNER (in OWTP)</strong></h4>
<h5><strong>17:30 - 19:00 POSTER SESSION</strong></h5>
<h5><strong>19:00 - 23:00 SOCIAL EVENT - Conference dinner, concert performance, guided underground tours</strong></h5>
<h3><strong>14th October 2021 (Thursday)</strong></h3>
<h4><strong>SESSION IV (in NLT)</strong></h4>
<p>(Chair: <a href="https://lcms.cz/articles?search=jan+preisler">Jan Preisler</a> (<a href="https://lcms.cz/companies/12">Masaryk University</a>, Czech Republic))</p>
<h5><strong>8:40 - 9:30 FT ICR Mass Spectrometry. Is There Room for Further Improvements? (virtual presentation)</strong></h5>
<ul>
<li><em>Evgeny Nikolaev (Skolkovo Institute of Science and Technology, Russia)</em></li>
</ul>
<h5><strong>9:30 - 10:00 Mass Spectrometry: from Metabolites to Art</strong></h5>
<ul>
<li><em>Karel Lemr (Palacký University Olomouc, Czech Republic)</em></li>
</ul>
<h5><strong>10:00 - 10:30 Historical Perspectives on Bruker’s Involvement in Mass Spectrometry and the Development of Modern Q-TOF Mass Spectrometry</strong></h5>
<ul>
<li><em>Gary H. Kruppa (Bruker, Czech Republic)</em></li>
</ul>
<h5><strong>COFFEE BREAK</strong></h5>
<h4><strong>SESSION V – YOUNG SCIENTISTS (in NLT)</strong></h4>
<p>(Chair: <a href="https://lcms.cz/articles?search=karel+lemr">Karel Lemr</a> (<a href="https://lcms.cz/companies/17">Palacký University Olomouc</a>, Czech Republic))</p>
<h5><strong>11:00 - 11:15 Identification of Novel Fatty Acids in Vernix Caseosa using UV Photodissociation Mass Spectrometry in Combination with Fixed-charge Photo-labile Derivatives</strong></h5>
<ul>
<li><em>Lukáš Cudlman (Institute of Organic Chemistry and Biochemistry of the CAS, Czech Republic)</em></li>
</ul>
<h5><strong>11:15 - 11:30 Mass Spectrometry-based Chemical Proteomics in Protein Post-translational Modifications Analysis</strong></h5>
<ul>
<li><em>Pavel Kielkowski (Ludwig-Maximilians-Universität München, Germany)</em></li>
</ul>
<h5><strong>11:30 - 11:45 Mapping of Regional and Subregional Unbound Drug Transport Across Blood-Brain Barrier Enabled by Quantitative Mass Spectrometry Imaging</strong></h5>
<ul>
<li><em>Dominika Luptáková (Uppsala University, Sweden)</em></li>
</ul>
<h5><strong>11:45 - 12:00 Visualization of Polyamines and Amino Acids Alterations in Neonatal Brain Hypoxic-Ischemic Injury in Rats by Mass Spectrometry Imaging</strong></h5>
<ul>
<li><em>Hynek Mácha (Institute of Microbiology of the CAS, Czech Republic)</em></li>
</ul>
<h5><strong>12:00 - 12:15 Temperature-Controlled Electrospray: A Window into Solution Thermochemistry of Non-Canonical Nucleic Acid Complexes</strong></h5>
<ul>
<li><em>Adam Pruška (ETH Zurich, Switzerland)</em></li>
</ul>
<h5><strong>12:15 - 12:30 Freeing Aspergillus fumigatus of Polymycovirus Infection renders it More Resistant to Competition with Pseudomonas aeruginosa due to Altered Iron-acquiring Tactics</strong></h5>
<ul>
<li><em>Rutuja Patil (Institute of Microbiology of the CAS, Czech Republic)</em></li>
</ul>
<h5><strong>LUNCH BREAK</strong></h5>
<h4><strong>SESSION VI (in NLT)</strong></h4>
<p>(Chair: Aleš Svatoš (Max Planck Institute for Chemical Ecology, Germany))</p>
<h5><strong>14:00 - 14:50 Native Ambient Mass Spectrometry: Mass Spectrometry Imaging of Intact Proteins and Protein Complexes (virtual presentation)</strong></h5>
<ul>
<li><em>Helen J. Cooper (University of Birmingham, United Kingdom)</em></li>
</ul>
<h5><strong>14:50 - 15:20 A (Time of) Flight from Ames to Brno: Laser Desorption Mass Spectrometry at Masaryk University</strong></h5>
<ul>
<li><em>Jan Preisler (Masaryk University, Czech Republic)</em></li>
</ul>
<h5><strong>15:20 - 15:50 The History of Time-of-Flight Mass Spectrometry at: VG - Micromass - Waters (virtual presentation)</strong></h5>
<ul>
<li><em>Mike Morris (Waters Corporation, Manchester, United Kingdom)</em></li>
</ul>
<h5><strong>15:50 - 16:20 Mass Spectrometry Innovation at Agilent Technologies (virtual presentation)</strong></h5>
<ul>
<li><em>George Stafford (Agilent Technologies, United States)</em></li>
</ul>
<h5><strong>16:20 - 16:30 CONFERENCE CLOSING</strong></h5>
<h4><strong>IOCB ChemBioDrug Workshop (in NLT</strong>)</h4>
<p>(Chair: <a href="https://lcms.cz/articles?search=josef+cvacka"> Josef Cvačka</a> (<a href="https://lcms.cz/companies/62">IOCB</a>, Czech Republic))</p>
<h5><strong>17:00 - 17:05 OPENING</strong></h5>
<h5><strong>17:05 - 17:25 Orbitrap Fusion Lumos: A Versatile Mass Spectrometer for Biomolecules</strong></h5>
<ul>
<li><em>Martin Hubálek (Institute of Organic Chemistry and Biochemistry of the CAS, Czech Republic)</em></li>
</ul>
<h5><strong>17:25 - 17:45 Protein Structure and Interactions Studied by Cross-Linking Mass Spectrometry</strong></h5>
<ul>
<li><em>Petra Junková (Institute of Organic Chemistry and Biochemistry of the CAS, Czech Republic)</em></li>
</ul>
<h5><strong>17:45 - 18:05 Protein Structure and Interactions Studied by Hydrogen Deuterium Exchange Mass Spectrometry</strong></h5>
<ul>
<li><em>Jakub Sýs (Institute of Organic Chemistry and Biochemistry of the CAS, Czech Republic)</em></li>
</ul>
<h5><strong>18:05 - 18:30 HPLC/ESI-MS2 – Based Lipidomic Analysis and MALDI Imaging of Lipids</strong></h5>
<ul>
<li><em>Vladimír Vrkoslav, Štěpán Strnad (Institute of Organic Chemistry and Biochemistry of the CAS, Czech Republic)</em></li>
</ul>
<h5><strong>18:30 - 19:00 Discussion / User Meeting</strong></h5>
<h5><strong>WORKSHOP CLOSING</strong></h5>
<p>Program je k dispozici také jako pdf na webu <a href="http://ms-prague2021.uochb.cas.cz/program.php">Prague Meeting on Historical Perspectives of Mass Spectrometry</a></p>


Conference Program Prague Meeting on Historical Perspectives of Mass Spectrometry

<p><strong>Dear friends and fans of mass spectrometry,</strong></p>
<p><strong>The history of a method for studying of matter known as mass spectrometry dates back more than a century. The foundations have mostly been laid by physics studying discharges in gases. After about five decades mass spectrometry entered the domain of chemistry and evolved into an excellent tool for studying the structure of chemical compounds. Recently we are witnessing its expansion into the field of cellular, molecular, and structural biology. The technology of mass spectrometry developed immensely over the time. Let us take a tour into the history and learn about the past technologies. Let us explore the state-of-art mass spectrometry.</strong></p>
<p>A technical museum focused on unique and significant part of science, the Czech Museum of Mass Spectrometry will display and explain laboratory instrumentation that encompasses physics, chemistry, engineering and informatics and combines them into a device that contributes to many parts of our daily life.</p>
<p>Czech and English speaking visitors will have an opportunity to learn about the principles and applications of mass spectrometry, its history, and important scientists including Nobel price winners, while experiencing a remarkable collection of mass spectrometers. Founded by mass spectrometry enthusiasts Jaroslav Pol (Thermo Scientific) and Josef Cvacka (Institute of Organic Chemistry and Biochemistry) and sponsored by Frantisek Turecek (University of Washington, Seattle), the Czech Museum of Mass Spectrometry is now being assembled and will open in Prague in 2017. Donations of mass spectrometry artifacts are gratefully appreciated; those willing to contribute please contact the curators.</p>
<p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/d3e7627196634c0a8fa129f95fef6edd/obrazek.png" alt="The Czech Museum of Mass Spectrometry"/></p>
<h3><strong>Mass spectrometry</strong></h3>
<p>Study of matter through the formation of gas-phase ions that are characterized using mass spectrometers by their mass, charge, structure, and/or physico-chemical properties.</p>
<h3><strong>Mass Analyzers</strong></h3>
<h5><strong>Fourier Transform Ion Cyclotron Resonance</strong></h5>
<p>Mass spectrometer based on the principle of ion cyclotron resonance in which an ion in a magnetic field moves in a circular orbit at the cyclotron frequency that is characteristic of its m/z value. Ions are coherently excited to a larger radius orbit using a pulse of radio frequency electric field, and their image charge is detected on receiver plates as a time domain signal. Fourier transformation of the time domain signal results in a frequency domain signal that is converted to a mass spectrum based on the inverse relationship between cyclotron frequency and m/z.</p>
<p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/1628c6d87adf47538f70c2d7ce971db9/obrazek.png" alt="The Czech Museum of Mass Spectrometry/Martin Strohalm"/></p>
<h5><strong>Ion Trap</strong></h5>
<p>Device for spatially confining ions using electric and magnetic fields alone or in combination.</p>
<p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/bcc0887a778f4df29f488bcd87ce8718/obrazek.png" alt="The Czech Museum of Mass Spectrometry/Martin Strohalm"/></p>
<h5><strong>Linear Ion Trap</strong></h5>
<p>Two-dimensional Paul ion trap in which ions are confined in the axial dimension by means of a static electric potential.</p>
<p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/6d35a6cdb4ee4baa95ad2d831b20db19/obrazek.png" alt="The Czech Museum of Mass Spectrometry/Martin Strohalm"/></p>
<h5><strong>Orbitrap</strong></h5>
<p>Ion trapping device that consists of an outer barrel-like electrode and a coaxial inner spindle-like elec- trode that form an electrostatic </p>
<p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/4c8de0a71fef446fa44829e9d37c8b62/obrazek.png" alt="The Czech Museum of Mass Spectrometry/Martin Strohalm"/></p>
<h5><strong>Sector</strong></h5>
<p>Device that produces a magnetic field perpendicular to a charged particle beam that deflects the beam to an extent that is proportional to the ratio of particle momentum and charge.</p>
<p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/240ae6e09cb443508bf7dce8309b2928/obrazek.png" alt="The Czech Museum of Mass Spectrometry/Martin Strohalm"/></p>
<h5><strong>Time of Flight</strong></h5>
<p>Mass spectrometer that separates ions by m/z in a field-free region after acceleration through a fixed accelerating potential. Ions of the same initial translational energy and different m/z require different times to traverse a given distance in the field-free region.</p>
<p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/0d0eaa3a8aa544d1abcca833a9e6e9ae/obrazek.png" alt="The Czech Museum of Mass Spectrometry/Martin Strohalm"/></p>
<h5><strong>Triple Quadrupole</strong></h5>
<p>Tandem mass spectrometer comprising two transmission quadrupole mass spectrometers in series, with a (non-selecting) RF-only quadrupole (or other multipole) between them to act as a collision cell.</p>
<p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/b6e4bd36ccb44cd8a93e84353b28a357/obrazek.png" alt="The Czech Museum of Mass Spectrometry/Martin Strohalm"/></p>
<h3><strong>Ion Sources</strong></h3>
<h5><strong>Atmospheric pressure chemical ionization</strong></h5>
<p>Atmospheric pressure chemical ionization (APCI) is chemical ionization of a sample that is a gas or nebulized liquid, using an atmospheric pressure corona discharge or beta emitter such as 63Ni.</p>
<p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/d562c1ce1a9f43c78d8a93a2c6c43932/obrazek.png" alt="The Czech Museum of Mass Spectrometry/Martin Strohalm"/></p>
<h5><strong>Atmospheric pressure photoionization</strong></h5>
<p>Atmospheric pressure photoionization (APPI) is direct ionization of molecules at atmospheric pressure by electron detachment induced by photons forming M+•, or atmospheric pressure chemical ionization in which the reactant ions are generated by photoionization of suitable dopant species and subsequent ion/molecule reactions of their molecular ions.</p>
<p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/828a17ec377a4313bdd59f9275192e87/obrazek.png" alt="The Czech Museum of Mass Spectrometry/Martin Strohalm"/></p>
<h5><strong>Desorption electrospray ionization</strong></h5>
<p>Desorption electrospray ionization (DESI) is formation of gas-phase ions from a solid or liquid sample at atmospheric pressure through the inter- action of electrosprayed droplets with the sample surface.</p>
<p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/86624af57b96403586bd27b3bafccec3/obrazek.png" alt="The Czech Museum of Mass Spectrometry/Martin Strohalm"/></p>
<h5><strong>Electrospray ionization</strong></h5>
<p>Electrospray ionization (ESI) is spray ionization process in which either cations or anions in solution are transferred to the gas phase via formation and desolvation at atmospheric pressure of a stream of highly charged droplets that result from applying a potential difference between the tip of the electrospray needle containing the solution and a counter electrode.</p>
<p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/673ec39a73b64561805cf60670486635/obrazek.png" alt="The Czech Museum of Mass Spectrometry/Martin Strohalm"/></p>
<h5><strong>Fast atom bombardment ionization</strong></h5>
<p>Fast atom bombardment ionization (FAB) is ionization of molecules initiated by a beam of neutral atoms with translational energies in the keV range. Labile molecules susceptible to dissociation are dissolved in an involatile liquid matrix that absorbs the energy of the bombarding atoms to form a selvedge region above the liquid surface in which ionization of the molecules occurs.</p>
<p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/afda171085f54f6e856bc930cf873fca/obrazek.png" alt="The Czech Museum of Mass Spectrometry/Martin Strohalm"/></p>
<h5><strong>Matrix-assisted laser desorption/ionization</strong></h5>
<p>Matrix-assisted laser desorption/ionization (MALDI) is formation of gas-phase ions from molecules present in a solid or liquid matrix that is irradiated with a laser. The matrix is a material that absorbs the laser energy and promotes ionization.</p>
<p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/39f899169e27496f938621f0d25a0f12/obrazek.png" alt="The Czech Museum of Mass Spectrometry/Martin Strohalm"/></p>
<h5><strong>Secondary ion mass spectrometry</strong></h5>
<p>Secondary ion mass spectrometry (SIMS) is technique in which a focused beam of primary ions produces secondary ions by sputtering from a solid surface. The secondary ions are analyzed by mass spectrometry.</p>
<p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/fd584fd784ab4c5197b461de5c42c5ee/obrazek.png" alt="The Czech Museum of Mass Spectrometry/Martin Strohalm"/></p>


The Czech Museum of Mass Spectrometry

<p><strong>The origins of mass spectrometry in Czechia date back to the 1950s when a group of young scientists in the newly founded Czechoslovak Academy of Sciences started to build the first mass spectrometer in the country. Over the years, mass spectrometry gradually developed and gained in importance. The conference will explore the history, status and perspectives of mass spectrometry. It will mark the opening of the Czech Mass Spectrometry Museum and contribute to celebrations of 70th anniversary of mass spectrometry in our region.</strong></p>
<h3><strong>Organizing institutions</strong></h3>
<p><a href="https://gcms.cz/companies/22">ÚOCHB/IOCB PRAGUE</a></p>
<p><a href="https://gcms.cz/companies/21">Czech Society for Mass Spectrometry/Česká společnost pro hmotnostní spektrometrii</a></p>
<p><a href="https://gcms.cz/companies/7">Ioannes Marcus Marci Spectroscopic Society/Spektroskopická společnost Jana Marka Marci</a></p>
<p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/03cce7b42575402eb5c91750579dec76/obrazek.png" alt="ÚOCHB/IOCB PRAGUE - Czech Society for Mass Spectrometry/Česká společnost pro hmotnostní spektrometrii -  Ioannes Marcus Marci Spectroscopic Society/Spektroskopická společnost Jana Marka Marci"/></p>
<h3><strong>Conference program</strong></h3>
<p>Available on <a href="http://ms-prague2020.uochb.cas.cz/program.php">Prague Meeting on Historical Perspectives of Mass Spectrometry website</a></p>
<h3><strong>Venue</strong></h3>
<p>The conference will take place in three localities in Prague districts Dejvice and Bubeneč: National Library of Technology (lectures), Institute of Organic Chemistry and Biochemistry of the CAS (vernissage tours), and Old Wastewater Treatment Plant (poster session &amp; dinner).</p>
<p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/0827c374acec4191b3ff1610c02ae928/obrazek.png" alt="ÚOCHB/IOCB PRAGUE: Prague Meeting on Historical Perspectives of Mass Spectrometry"/></p>
<h3><strong>Czech Museum of Mass Spectrometry</strong></h3>
<p>The museum aims to collect and display artifacts related to mass spectrometry, especially those associated with our geographical region. The technical museum shows key components of mass spectrometers used in the past and in contemporary laboratory practice, and it also displays historical documents, photographs, books, etc. The museum&#39;s mission is expressed in two words: education and inspiration. It demonstrates technologies hidden behind the cover and inside the vacuum systems, thus allowing a better understanding how the mass spectrometers actually work. Displayed technical solutions, prototypes, ideas, and stories can be inspiring for students, scientists, and designers of instruments.</p>
<p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/8619b6eab01a4ec18b531bf1a7d20dff/obrazek.png" alt="ÚOCHB/IOCB PRAGUE: Czech Museum of Mass Spectrometry"/></p>
<h3><strong>Exhibition</strong></h3>
<p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/3bc183e590444d81a74ce5538a9b5b59/obrazek.png" alt="ÚOCHB/IOCB PRAGUE: Czech Museum of Mass Spectrometry"/></p>
<h3><strong>Website</strong></h3>
<p>The <a href="http://www.ms-museum.org/">website</a> will store the museum database with a detailed description of exhibits and bring topics from MS history.</p>
<p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/c4771b1119d84181929ea3cd97c56e76/obrazek.png" alt="ÚOCHB/IOCB PRAGUE: Czech Museum of Mass Spectrometry"/></p>
<h3><strong>Donations</strong></h3>
<p>The Czech Museum of Mass Spectrometry welcomes donations to its collection: instruments or their parts (broken, damaged, unused), and documents, photographs or books related to MS history. </p>


Prague Meeting on Historical Perspectives of Mass Spectrometry and  the Czech Mass Spectrometry Museum

<p><strong>The TRILAB DeltiQ 2, 3D printer from the Brno-Hradec Králové company TRILAB is a high-quality 3D printer from the so-called pro-sumer segment of the desktop 3D printer category. It is a printer completely developed by TRILAB, designed and built only from high-end components. Its hardware and software is adapted and tuned for short, but also multi-day prints even without the presence of an operator. Thanks to the remote-control software and the built-in camera with lighting, the user is constantly in control of printing. Also in the case of ambiguity, question or problem, the printer is immediately remotely diagnosed by the TRILAB service team.</strong></p>
<p>Thanks to the technical and application support of the TRILAB team and also thanks to the many years of experience of the two main partners of TRILAB in the field of <strong>science and research</strong>, where <strong>Dr. Vojtěch Tambor</strong> is originally the leading researcher in the laboratory of the Center for Biomedical Research (CBV) of the University Hospital HK and <strong>Dr. Michal Boháč</strong> is a former director of Bruker s.r.o., every scientific customer is always perfectly professionally secured and can thus focus only on solving their own challenges and projects.</p>
<p>Thanks to practical experience with placing 3D printers in research laboratories, TRILAB also knows very well that the <strong>DeltiQ 3D printer does not only allow its owners to save time and money</strong> in producing things that are familiar and hard to reach, but also and above all <strong>to create and quickly test completely new things, not yet discovered</strong>. In addition, it allows them to be pampered by the quality of the printing surface, spatial accuracy, huge print volumes or even just the grace of delta kinematics movements. In addition, <strong>the customer does not have to buy</strong> the printer as an investment, but can <strong>rent it</strong> or cleverly buy it under an <strong>initial operating lease</strong> with a possible subsequent purchase. This not only divides the financial costs of its acquisition over a longer period, but also avoids possible lengthy approval processes for investment purchases.</p>
<p>The DeltiQ 3D printer will become a great help in your research project. Whether it&#39;s <strong>simple holders or specialized components</strong>, with a 3D printer you can <strong>save not only most acquisition costs, but also a lot of time spent</strong> looking for a suitable tool. In addition, you can create <strong>tools that you cannot buy as they do not exist!</strong> And besides tools, you can also create your own prototypes, products or their models and replacements.</p>
<h3><strong>The story of <a href="https://www.nenovision.com/">NenoVision</a>: Thanks to 3D printing, our microscope can be touched safely</strong></h3>
<p>NenoVision is a start-up originating from the Central European Institute of Technology <strong>CEITEC</strong> and is one of the incubated companies in the South Moravian Innovation Center <strong>JIC INMEC</strong>. They are proud that their <strong>LiteScope microscope</strong> is the only one in the world that can combine data from an electron microscope and an atomic force microscope in detail and assemble them into 3D models. It literally opens up a new dimension of research.</p>
<p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Trilab_Neno_Vision_mikroskop_1_6b79421014/Trilab-NenoVision-mikroskop-1.jpg" alt="TRILAB: NenoVision - model of LiteScope microscope printed on the TRILAB DeltiQ printer"/></p>
<p>The company found the application of 3D printing in solving the problem of how to enable the &quot;touch&quot; of the microscope to partners, customers and the professional public: <em>&quot;LiteScope normally works in a controlled environment, moreover in a vacuum, and it is a sensitive and very expensive device. Therefore we or our distributors cannot normally carry it to all events and exhibitions, nor provide it to our partners for tests for insertion into their machines,”</em> explains <strong>Jan Neumann, the owner and CEO of NenoVision</strong>.</p>
<p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Trilab_Neno_Vision_mikroskop_2_8d96758735/Trilab-NenoVision-mikroskop-2.jpg" alt="TRILAB: NenoVision - model of LiteScope microscope printed on the TRILAB DeltiQ printer"/></p>
<p>Machining the individual components of the microscope itself is so expensive that even making a copy of the instrument without &quot;living&quot; components does not make sense. In the end, <strong>3D printing proved to be an elegant solution</strong>: <em>“Since the complete 3D model for production was already ready, it was enough to prepare and print it on a TRILAB DeltiQ printer and the model of the device in perfect quality and accuracy was born. In this way, it can be easily reproduced and shown to customers and the public at a fraction of the normal cost,”</em> adds Jan Neumann. </p>
<h3><strong><a href="https://www.biocev.eu/en">BIOCEV</a> story: Own online nanospray built in a few days?</strong></h3>
<p>The story of <a href="http://peterslab.org"><strong>Dr. Petr Novák</strong></a> from BIOCEV shows the second group of 3D printing options. Building something that does not exist, that you cannot buy, and you know what it should look like and you need it. Dr. Novák&#39;s team happened to be in exactly the same situation. <strong>Commercially available nanosprays did not meet the requirements</strong> not only in terms of compatibility with available spectrometers, but also in terms of real sensitivity, essential for measurement. That&#39;s why the <em>&quot;Do it yourself&quot;</em> mode came into play. Thanks to the clever <strong>use of 3D printing, a nanospray was created</strong>, which has <strong>ncomparably higher sensitivity</strong> and operator comfort compared to all commercial devices available on the market. </p>
<p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Trilab_BIOCEV_online_nanosprej_1_ac1e93326c/Trilab-BIOCEV-online-nanosprej-1.jpg" alt="TriLab: BIOCEV - online nanospray"/></p>
<p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Trilab_BIOCEV_online_nanosprej_2_ba9dbfde99/Trilab-BIOCEV-online-nanosprej-2.jpg" alt="TriLab: BIOCEV - online nanospray"/></p>
<h3><strong>The story of the MALDI-TOF plate suitable not only for affinity chromatography</strong></h3>
<p>As part of the projects of <strong>AffiPro</strong>, a spin-off company under <strong>BIOCEV Prague</strong>, it has been running for several years under the leadership of <strong>Dr. Petr Novák and Dr. Petr Pompach</strong> for the development of clinical applications of affinity chromatography on MALDI-TOF spectrometry, for example <strong>MALDI Biotyper</strong> devices, by patented application of various antibodies to MALDI plates using the so-called soft ion landing technology. Although this is a technology that is just beginning and commercial use is yet to come, they already have several very interesting surfaces on their own chips in the laboratory, which will be interesting in the future not only for clinical and veterinary, but also for military screening. And thanks to the use of 3D printing technology, they have the opportunity to <strong>print not only different surfaces and shapes</strong>, but also to use <strong>different materials on MALDI chips</strong> and thus, for example, <strong>increase the sensitivity and detection limits</strong> of the method. </p>
<p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Trilab_Affi_Pro_MALDI_TOF_desticka_836e1e69b7/Trilab-AffiPro-MALDI-TOF-desticka.png" alt="TriLab: AffiPro/BIOCEV - MALDI-TOF chip for affinity chromatography"/></p>
<p>The original article <a href="https://pubs.acs.org/doi/pdf/10.1021/acs.analchem.0c01737">Three-Dimensional Printed Target Plates for Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry ke stažení.</a></p>


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