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Ústav organické chemie a biochemie AV ČR
The Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences (IOCB Prague) is a leading scientific institution in the Czech Republic, recognized internationally. Its primary mission is basic research in the fields of chemical biology and medicinal chemistry, organic and material oriented chemistry, chemistry of natural compounds, biochemistry and molecular biology, physical chemistry, theoretical chemistry, and analytical chemistry.
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Azopyrimidine photoswitches and their interactions with cyclodextrins

Th, 11.4.2024
| Original article from: IOCB Prague
Azopyrimidine photoswitches become encapsulated into β-cyclodextrin (CD) cavity selectively via their phenyl ring.
- **Photo:** IOCB Prague: Azopyrimidine photoswitches and their interactions with cyclodextrins.
  • Photo: IOCB Prague: Azopyrimidine photoswitches and their interactions with cyclodextrins.

Researchers led by Eliška Procházková from IOCB Prague have found that azopyrimidine photoswitches become encapsulated into β-cyclodextrin (CD) cavity selectively via their phenyl ring. The strength of the complex is tuned by structural modification of azopyrimidine.

In the strongest complexes, the trans-to-cis isomerization proceeds inside the CD cavity. In the weak complexes, azopyrimidine in the trans isomer is complexed via the narrower primary portal and released from the CD cavity upon irradiation. Consequently, the resulting cis isomer is re-complexed through the wider secondary portal.

This research highlights the applicability of these and similar types of supramolecular assemblies as a function of the interaction strength and mutual orientation of host and guest molecules, which have been studied for the first time in cases of cyclodextrin-azenyl couples by a combined NMR spectroscopy-capillary electrophoresis-quantum chemistry approach.

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Hruzíková, A.; Mužíková Čechová, L.; Štěpánová, S.; Tučková, L.; Tichotová M.; Růžička, A.; Kašička, V.; Procházková, E. A study of azopyrimidine photoswitches and their interactions with cyclodextrins: When the guest governs the type of accommodation at the host. Dyes and Pigments 2023, 212, 111099. https://doi.org/10.1016/j.dyepig.2023.111099

Ústav organické chemie a biochemie AV ČR
 

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