Cells in the human body constantly evaluate signals from their surroundings and decide whether to divide, grow, or remain inactive. One of the key systems controlling this communication is the so-called Wnt signalling pathway. If this mechanism becomes disrupted, cells can spiral out of control, leading to uncontrolled growth and the development of tumours. Scientists from CEITEC and the Faculty of Science at Masaryk University have now described a critical decision-making process – the point at which a cell’s future development is decided. Their findings may, in the future, contribute to the search for ways to slow down or stop such processes in diseases like cancer.The Wnt signalling pathway is a mechanism that coordinates billions of cells in the body – it is responsible for the development of an entire organism from a single cell, and it continues to regulate tissue renewal throughout adult life. Until now, it was not fully understood how this mechanism works in detail. However, new research by teams from Masaryk University (MUNI) shows that the cells do not respond to stimuli smoothly, but rather operate in an on-off mode once a certain decision-threshold is crossed. This principle changes our understanding of how cells function together and helps explain situations in which cellular decision-making goes out of control and may lead to cancer development.The process begins at the surface of the cell, where a signal is captured by a receptor embedded in the cell membrane. A protein called Dishevelled (DVL) then binds to this receptor and carries the signal further into the cell. However, for the signal to continue, DVL must first undergo a series of chemical modifications. Small chemical groups begin to accumulate on its surface, progressively increasing its negative charge.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/CEITEC_Vedci_nasli_bod_zlomu_v_bunce_Prave_takto_muze_zacit_rakovina_4_7c8f80376d.jpg" alt="CEITEC/Tripsianes Lab: Scientists Uncover a Tipping Point in Cells. This Is How Cancer May Begin: New mechanism of Wnt signal transduction " srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_CEITEC_Vedci_nasli_bod_zlomu_v_bunce_Prave_takto_muze_zacit_rakovina_4_7c8f80376d.jpg 245w," sizes="100vw" width="1600" height="604">And this is where the decisive moment occurs.“We found that the DVL protein behaves like a switch – its structure changes abruptly once the negative charge on its surface exceeds a certain threshold. Only then does it rearrange and allow the signal to proceed further,” explains first author <a target="_blank" rel="noopener noreferrer" href="https://www.ceitec.eu/miroslav-micka/u92423?page=publication">Miroslav Micka</a>.At this point, DVL detaches from the receptor, allowing the signal to move deeper into the cell. The cell then receives a clear instruction on how to respond – for example, to start dividing or change its function.This crucial “tipping point,” where the fate of the signal is decided, has so far been only partially understood: “Scientists knew the pathway the signal follows, but they mostly viewed it as a gradual regulatory system. However, our teams have shown that it is rather a process based on decision points and abrupt changes once a certain threshold is crossed. This is important not only for understanding how cells function, but also for explaining what happens when these processes become dysregulated,” add corresponding authors <a target="_blank" rel="noopener noreferrer" href="https://www.ceitec.eu/konstantinos-tripsianes-ph-d/u17552?page=publication">Konstantinos Tripsianes</a> from CEITEC MUNI and <a target="_blank" rel="noopener noreferrer" href="https://www.muni.cz/en/people/11088-vitezslav-bryja">Vítězslav Bryja</a> from the Faculty of Science.Such decision points in cellular signalling are particularly important from a medical perspective, as their disruption can trigger processes that lead to tumour development. A better understanding of these processes, on the other hand, paves the way for more effective treatments.The study was published in the journal <a target="_blank" rel="noopener noreferrer" href="https://www.science.org/doi/10.1126/sciadv.aed8899">Science Advances</a>.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/CEITEC_Vedci_nasli_bod_zlomu_v_bunce_Prave_takto_muze_zacit_rakovina_2_af629ac80a.jpg" alt="CEITEC/Tripsianes Lab: Scientists Uncover a Tipping Point in Cells. This Is How Cancer May Begin: DVL in a cell (green), cell nucleus (blue)" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_CEITEC_Vedci_nasli_bod_zlomu_v_bunce_Prave_takto_muze_zacit_rakovina_2_af629ac80a.jpg 156w," sizes="100vw" width="1600" height="1600"><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/CEITEC_Vedci_nasli_bod_zlomu_v_bunce_Prave_takto_muze_zacit_rakovina_36bfbfa0c6.jpg" alt="CEITEC/Tripsianes Lab: Scientists Uncover a Tipping Point in Cells. This Is How Cancer May Begin: DVL in a cell (green), enzym modifiyng DVL (red), cell nucleus (blue)" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_CEITEC_Vedci_nasli_bod_zlomu_v_bunce_Prave_takto_muze_zacit_rakovina_36bfbfa0c6.jpg 156w," sizes="100vw" width="1600" height="1600"><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/CEITEC_Vedci_nasli_bod_zlomu_v_bunce_Prave_takto_muze_zacit_rakovina_3_f21d18e3ca.jpg" alt="CEITEC/Tripsianes Lab: Scientists Uncover a Tipping Point in Cells. This Is How Cancer May Begin: DVL in a cell (green), enzym modifiyng DVL (red), cell nucleus (blue)" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_CEITEC_Vedci_nasli_bod_zlomu_v_bunce_Prave_takto_muze_zacit_rakovina_3_f21d18e3ca.jpg 156w," sizes="100vw" width="1600" height="1600">&nbsp;<blockquote><h4>Original article</h4><h4><a target="_blank" rel="noopener noreferrer" href="https://www.science.org/doi/10.1126/sciadv.aed8899">A Wnt-induced conformational phospho-switch in DVL3 controls association with Frizzled receptors and Wnt/β-catenin signaling</a></h4>Miroslav Micka, Jitender Kumar, Petra Paclíková, Zuzana Hayek, Kateřina Hanáková, Cherine Bechara, Hana Plešingerová, Ondrej Šedo, Sara Bologna, Elise Del Nero, Kristína Gömöryová, Vojtěch Bystrý, Tomáš Gybel, Tereza Čihalová, Marek Kravec, David Potěšil, Zbyněk Zdráhal, Konstantinos Tripsianes a Vítězslav Bryja.Sci. Adv., 2026, 12(20), eaed8899<a target="_blank" rel="noopener noreferrer" href="https://doi.org/10.1126/sciadv.aed8899">DOI: 10.1126/sciadv.aed8899</a><h6>licenced under <a target="_blank" rel="noopener noreferrer" href="https://creativecommons.org/licenses/by/4.0/">CC-BY 4.0</a></h6></blockquote><h4>Abstract</h4>It is well known that Dishevelled (DVL) phosphorylation by casein kinase 1 (CK1) relays Wnt signals from Frizzled (FZD) receptors to downstream effectors, yet any mechanistic aspects of DVL function related to phosphorylation remain unresolved. Here, we uncovered a Wnt-induced DVL phospho-switch that is mutually exclusive with FZD association. CK1 multiphosphorylation changes dramatically the bulk electrostatics to promote DVL intramolecular interaction between the DEP domain and the adjacent disordered region. A panel of DVL3 mutants demonstrated a switch-like behavior at the molecular level when a charge threshold was reached. Charge accumulation proximal to DEP proved to be a key functional event required, but not sufficient, for Wnt/β-catenin signaling. Proximity interactomics revealed FZD receptors as the prominent effectors of the DVL phospho-switch function consistent with the molecular competition at the DEP interface. By integrating findings at different levels, we propose a universal mechanism, in which Wnt-induced DVL conformational phospho-switch attenuates coresidence with FZDs as a means for downstream signaling events.

 Scientists Uncover a Tipping Point in Cells. This Is How Cancer May Begin 

Time is running out to take advantage of discounted registration fees for the 19th Czech-Slovak Spectroscopic Conference (19th CSSC), one of the leading scientific events dedicated to spectroscopy and spectrometry in Central Europe. Researchers, students, instrument specialists, and industry professionals are invited to join the conference at the Faculty of Science, Palacký University Olomouc. The Early Bird registration period and the deadline for lecture and poster abstract submission both end on June 15, 2026.&nbsp;<h3>Registration</h3><blockquote>👉<a target="_blank" rel="noopener noreferrer" href="https://cssc2026.spektroskopie.cz/registration_online">Online registration form</a></blockquote><h4>Registration Fees</h4><h5>Early (before June 15, 2026)</h5><ul><li>Participant (Member of IMMSS and SSS): 10 000 CZK&nbsp;&nbsp;</li><li>Participant (Non-member of IMMSS and SSS): 14 000 CZK&nbsp;&nbsp;&nbsp;</li><li>Students: 7 000 CZK&nbsp;</li><li>1-day registration: 5 000 CZK</li><li>Accompanying person*: 5 000 CZK</li></ul><h5>Regular (after June 15, 2026)</h5><ul><li>Participant (Member of IMMSS and SSS): 13 000 CZK&nbsp;&nbsp;</li><li>Participant (Non-member of IMMSS and SSS): 18 200 CZK&nbsp;&nbsp;&nbsp;</li><li>Students: 9 100 CZK&nbsp;</li><li>1-day registration: 6 500 CZK</li><li>Accompanying person*: 6 500 CZK</li></ul>* The accompanying person does not have access to the scientific programmeThe conference fee is calculated with VAT and includes:<ul><li>attendance to lectures and poster session</li><li>book of abstracts (electronic version)</li><li>booklet</li><li>lunches, refreshments (coffee/tea breaks)</li><li>excursion</li><li>attendance at Welcome Party and Gala Dinner.&nbsp;</li></ul>For an accompanying person, the conference fee includes the Welcome Party, the excursion and the Conference Dinner. The Conference Dinner is not included in the 1-day registration. This payment should be arranged with the Organising Committee.Accommodation is not included in the conference fee.<h3>Abstract submission</h3><blockquote>👉<a target="_blank" rel="noopener noreferrer" href="https://cssc2026.spektroskopie.cz/abstract_submission_online">ABSTRACT SUBMISSION FORM</a>Deadline for lecture/poster abstract submission is June 15, 2026</blockquote><h4>Posters</h4>Prepare your poster in English in the format A0 vertically orientated (portrait). The presence of one of the authors at the poster is requested during the poster session. Materials for mounting posters will be available on the poster panels.<h4>Lectures</h4>Prepare your presentation in English in PowerPoint of Portable Document Format (pdf), both in format 16:9 (widescreen). Invited and oral lectures takes 30 and 20 minutes (including discussion), respectively.&nbsp;<h3>TOPICS &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp;&nbsp;</h3><h4>Czech - Slovak Spectroscopic Conference</h4><ul><li>Atomic spectrometry (AAS, ICP-MS, AFS, OES, speciation analysis, etc.)</li><li>Molecular spectrometry/spectroscopy (UV-Vis, NMR, IR, Raman, circular dichroism, etc.)</li><li>New techniques and data processing methods in IR and Raman spectroscopy, Special methods of Raman spectroscopy (resonance Raman, SERS, SERRS, TERS)</li><li>XRF spectrometry (EDS, WDS, XRF, PIXE, etc.)</li><li>Mass spectrometry &amp; hyphenated techniques</li><li>Instrumental radioanalytical methods (Gamma spectroscopy, NAA, etc.)</li><li>Laser spectroscopy and special spectroscopy techniques</li><li>Sample preparation and introduction techniques</li><li>Applications &nbsp;of atomic and molecular spectroscopy</li><li>Statistics and metrology in spectroscopy</li></ul><h4>Mössbauer Spectroscopy in Material Science</h4><ul><li>Environmental, catalytic, biologic, medical applications</li><li>Magnetism, magnetic nanoparticles, molecular magnets</li><li>Nanomaterials, nanostructures, nanocomposites, core-shell nanoparticles, thin films</li><li>Nanomaterials in biomedicine</li><li>Nuclear forward scattering in materials science</li><li>Solid-state chemistry and physics</li><li>Industrial applications, corrosion</li><li>Instrumentation, software</li><li>Earth Science, Mineralogy and Archaeology</li></ul><h4>Venue</h4><h5>Faculty of Science</h5><ul><li>Palacky University Olomouc</li><li>17. listopadu 1192/12, &nbsp;Olomouc, Czech Republic</li></ul>

19th CSSC 2026: Early Bird Registration and Abstract Submission Deadline Approaching

Our Library never stops expanding. What are the most recent contributions to LabRulezICPMS Library in the week of 8th June 2026? Check out new documents from the field of spectroscopy/spectrometry and related techniques!<blockquote>👉 <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/library">SEARCH THE LARGEST REPOSITORY OF DOCUMENTS ABOUT SPECTROSCOPY/SPECTROMETRY RELATED TECHNIQUES</a></blockquote><blockquote>👉 Need info about different analytical techniques? Peek into <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/library">LabRulezLCMS</a> or <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library">LabRulezGCMS</a> libraries.</blockquote>This week we bring you application notes by Agilent Technologies, Shimadzu and Thermo Fisher Scientific!<h3>1. Agilent Technologies: Fast and Reliable Analysis of Soil and Sediments using ICP-MS with an Innovative Cell</h3>High-throughput and low detection limits with the <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/library?mainauthorItems=10&amp;search=9500">Agilent 9500 ICP-QQQ</a> and a Dual-Cell System&nbsp;<ul><li>Application note</li><li><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/labrulez-bucket-strapi-h3hsga3/an_soil_sediment_9500_icp_qqq_5994_9128en_agilent_affabfb736.pdf">Full PDF for download</a></li></ul>Ever since ICP-MS instruments were first commercialized, their high sensitivity and multi-elemental capabilities have made them a suitable technique for quantifying trace elements in soil and sediment, particularly in support of environmental monitoring and regulatory compliance. To help laboratories transition to ICP-MS for these important environmental applications, the US Environmental Protection Agency (EPA) first introduced the performance-based test Method 6020 in 2007, and revised it as Method 6020B in 2014.1 Method 6020B remains widely used worldwide for the quantitative measurement of a broad range of elements, including arsenic (As), cadmium (Cd), mercury (Hg), selenium (Se), and lead (Pb), in solid and aqueous wastes by ICP-MS.&nbsp;Traditionally, single-quadrupole ICP-MS (SQ ICP-MS) instruments equipped with collision/reaction cells (CRCs) have been used to meet the requirements of Method 6020B for sample analysis. Laboratories have typically used a combination of acquisition strategies to control interferences, including no gas mode for interference-free analytes and low mass analytes, helium (He) collision mode for analytes affected by polyatomic ion interferences, and half-mass mode to correct doubly charged ion (M2+) interferences. This multi-mode approach has enabled laboratories to meet Method 6020B performance and quality control (QC) criteria over many years.&nbsp;Now, for the first time, the <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/library?mainauthorItems=10&amp;search=9500">Agilent 9500 Triple Quadrupole ICP-MS</a> featuring the Dual-Cell System (DCS) cell introduces two innovative cell gas modes, Advanced Helium Mode (AHM) and Air cell mode.2,3 These modes simplify interference removal approaches, enhance analytical performance, and accelerate analysis timesIn this study, a range of environmentally certified reference materials (CRMs) was selected to represent sample types routinely analyzed in high-throughput environmental testing laboratories. As these laboratories prioritize productivity across all aspects of their operations to remain competitive, the 9500 ICP-QQQ configuration and analytical method were optimized to maximize sample throughput. The performance of the method was evaluated according to criteria set out in Method 6020B.<h4>Conclusion&nbsp;</h4>The study has shown that the Agilent 9500 ICP-QQQ, equipped with the unique Dual-Cell System (DCS) and the optional AVS&nbsp;MS discrete sampling system, is ideal for high-throughput, multi-element analysis of soil and sediment samples.&nbsp;The use of the EPA 6020B Preset Method and selection of UHMI-4 plasma conditions in the Agilent OpenLab ICP-MS software enabled rapid setup of the instrument’s operating parameters, ensuring consistent performance across operators.&nbsp;The instrument’s matrix-tolerant plasma (low CeO/Ce ratio), UHMI, and DCS effectively addressed the challenges of analyzing high-matrix samples, including signal drift, ion suppression, and spectral interferences, thereby delivering an optimized analytical workflow.&nbsp;The method’s productivity was enhanced by operating the DCS in Advanced Helium Mode (AHM) and Air cell mode and by using short integration times, saving 5 to 10 s per sample. AHM replaces conventional no gas, helium (He) collision, and high energy He (HEHe) in a single mode, while Air cell mode uses oxygen from the laboratory, alleviating the need for gas cylinders. The 9500 maintains exceptionally high sensitivity in AHM and Air cell mode, minimizing background signals.&nbsp;Overall, the 9500 ICP-QQQ with DCS achieved excellent analytical data:&nbsp;<ul><li>Low detection limits in the low ng/L (ppt) range for most analytes.&nbsp;</li><li>Removal of M2+ interferences on Ca, As, and Se generated by Sr and rare earth elements (REEs) in the soil samples using Air cell mode.&nbsp;</li><li>Recoveries of all certified elements in the five environmental CRMs or matrix spike samples within 100 ± 10%, confirming the effective control of interferences using AHM and Air cell mode.&nbsp;</li><li>Method robustness and reproducibility over more than eight hours of continuous measurements, as demonstrated by the recoveries of ISTDs and CCVs within the limits specified in EPA Method 6020.&nbsp;</li></ul>The 9500 ICP-QQQ with DCS and an integrated AVS MS enables high-throughput, routine analysis of complex environmental matrices. The EPA Method 6020-compliant method provided accurate data by effectively handling polyatomic ion and M2+ interferences using AHM and Air cell mode.<h3>2. Shimadzu: Strength Testing of Lithium-Ion Battery Materials Using a Continuous-Testing Micro-Compression Testing Machine</h3><ul><li>Application note</li><li><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/labrulez-bucket-strapi-h3hsga3/an_01_01168_en_d2eb3ddbcb.pdf">Full PDF for download</a></li></ul><h4>User Benefits</h4><ul><li>The tests are automated, which significantly reduces the time required of the operators.</li><li>Up to 100 continuous tests can be performed.</li><li>Particle size measurement is performed by software, which reduces differences in measurement between operators</li></ul>Lithium-ion batteries have become an indispensable energy source in a wide range of fields, from everyday items like smartphones and laptops to electric vehicles and renewable energy storage systems. The batteries consist of a positive electrode, a negative electrode, an electrolyte, and a separator. Positive electrodes use transition metal oxides (e.g., lithium nickel manganese cobalt oxide [NMC]) or lithium iron phosphate (LFP) to transfer lithium, and negative electrodes generally use graphite and, recently, high-capacity materials, such as silicon. One of the issues with lithium-ion batteries is that the positive and negative electrodes are prone to cracking. This is caused by the high pressures during manufacturing, as well as during charging and discharging. This is also thought to affect their performance, such as the cycle properties. Therefore, research is being conducted on the relationship between mechanical properties and the electrochemical performance. 1), 2) This Application News presents compression tests on various battery materials as examples of quantitative evaluations of their mechanical properties. The MCT series of microcompression testing machines can perform compression testing of minute single particles. In addition, the MCT-AD model can automatically perform extraction of measurement particles, length measurements, and test operations. This results in significant time savings and enables evaluations with a larger number of measurements.<h4>MCT-AD Micro Compression Testing Machine&nbsp;</h4>Fig. 1 shows the MCT-AD and the measurement principle. The MCT compressed single particles placed on a lower compression plate using a flat indenter. Then, using data on diameters of the particles obtained in advance, a test forcedisplacement graph was created that measured various types of strength of the particles. The MCT-AD automatically performs selection of the measurement particles, length measurements, and cleaning of the indenter, which in the past had to be performed manually by the operator after each measurement. This enables continuous testing up to 100 times while consolidating the operation time by the operator and reducing labor.<h4>Conclusion&nbsp;</h4>This Application News presents a mechanical evaluation by the MCT-AD of materials used in the electrodes of lithium-ion batteries. Traditionally, this measurement process imposes a heavy workload on operators. But since the MCT-AD automatically performs extraction of measurement particles, length measurements, and test operations, there are significant labor savings, and the need for highly skilled operators is also eliminated. The MCT-AD can also handle compression testing of samples with minute particle shapes, not just battery materials, so it is useful not only for product development but also for quality control.<h3>3. Thermo Fisher Scientific: Real-time zinc-nickel coating measurements.</h3><h4>Thickness and composition analysis using the Niton XL5 Plus Handheld XRF Analyzer</h4><ul><li>Application note</li><li><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/labrulez-bucket-strapi-h3hsga3/an1685_en_12_2025_2911000_31d7d7fbe6.pdf">Full PDF for download</a></li></ul>Zinc-nickel (Zn-Ni) coatings are the result of an electroplating process that deposits a layer of zinc-nickel alloy onto the surface of a metal substrate, typically steel. Zn-Ni coatings offer superior corrosion resistance compared to pure zinc coatings and often replace cadmium coatings, as they provide comparable or better properties while complying with regulations such as REACH (Registration, Evaluation, Authorization, and Restriction of Chemicals) and RoHS (Restriction of Hazardous Substances). Commonly used in the automotive, aerospace, and electronics industries, Zn-Ni coatings are often applied to fasteners, connectors, and structural parts exposed to corrosive environments.&nbsp;Zn-Ni coatings typically consist of 85-93% zinc (Zn) and 7-15% nickel (Ni). The exact composition may vary depending on the application’s specific requirements. The coating process involves electroplating, which consists of immersing the metal substrate in an electrolyte solution containing zinc and nickel ions. An electric current is then passed through the solution, causing the zinc-nickel alloy to deposit onto the substrate. To ensure that specifications for coated parts are met, metal finishing companies must verify both the coating thickness and composition.<h4>Instrumentation&nbsp;</h4>X-ray fluorescence spectrometry (XRF) is the technology of choice for quality control of Zn-Ni plating, as it is the only analytical method that can determine the thickness and composition of the coating layer non-destructively. The use of handheld X-ray fluorescence spectrometry (HHXRF) instruments enables near-line analyses of finished products, which can be analyzed directly without being cut and brought to a separate chamber with benchtop instruments.&nbsp;In previous work [1], the <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/products/1992">Thermo Scientific™ Niton™ XL5 Plus Handheld XRF Analyzer </a>was demonstrated to be capable of measuring the coating weight or coating thickness of up to 4 layers of metal coatings on a substrate, using a proprietary standardless “fundamental parameters” algorithm. The layers and the substrate can be pure elements or alloys. Although the fundamental parameters algorithm can determine the thickness of Zn-Ni plating standardless, it delivers partial information, as the composition of the layer is not measured. To measure the composition and the thickness of the coatings simultaneously, another approach using empirical calibration can be deployed. The Niton XL5 Plus User Mode enables the operators to create their own calibration curves based on the measurements carried out on reference materials of Zn-Ni plated samples with known coating thickness and composition.<h4>Conclusion&nbsp;</h4>Performing quality control of Zn-Ni coatings is essential for metal finishers to ensure the corrosion resistance of critical parts used in the automotive and aerospace industries. The Niton XL5 Plus analyzer calibrated with user mode for this application has demonstrated its ability to deliver accurate results and numerous benefits to the metal finishing industry, including but not limited to these:&nbsp;<ul><li>Increased productivity thanks to real-time, near-line results for faster process control and reduced rework.&nbsp;</li><li>Preservation of high-value parts due to non-destructive testing that requires no cutting or damage.&nbsp;</li><li>A lower operational burden with easy deployment and low total cost of ownership.</li></ul>

News from LabRulezICPMS Library - Week 24, 2026

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Science and research

Ioannes Marcus Marci Spectroscopic Society is a voluntary organization of scientific, scientific-pedagogical and professional workers in the field of spectroscopy, or legal entities engaged in scientific and application activities in this field, associated with joint activities. SSJMM was founded in 1949.

Spektroskopická společnost Jana Marka Marci

Since its establishment in 2011, CEITEC has quickly developed into a cutting-edge infrastructure for research which performs highly alongside the best institutes in Europe. Among the main priorities of CEITEC are the promotion of a motivating and dynamic international scientific environment, the provision of state-of-the-art research infrastructure, and the policy of open communication and equal opportunities.

CEITEC

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Agilent Technologies

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<div><div container-id="cq-colctrl-lt0" comp-id="A1"><div>The webinar “Analysis of the Key Parameters of Biofuels” provides a detailed overview of how biofuels—and solid fuels such as SRF (Solid Recovered Fuels)—can be analyzed efficiently with high sample throughput and outstanding analytical precision. Reliable fuel characterization is essential for quality control, process optimization, and regulatory compliance in energy generation and fuel trading.Biofuels are typically characterized by a range of critical parameters, all of which will be addressed in this webinar. These include MVA analysis (Moisture, Volatile Matter, Ash), CHNS determination (Carbon, Hydrogen, Nitrogen, Sulfur), calorific value determination, moisture analysis, and ash fusion behavior. The webinar will explain how these parameters are measured, how they influence fuel performance, and how modern analytical systems support fast and reproducible results.CHNS determination plays a central role in the evaluation of biofuels, as elemental composition directly affects combustion behavior, energy content, and emission potential. Accurate CHNS data are essential for calculating stoichiometric combustion conditions, assessing fuel quality, and ensuring compliance with environmental and technical specifications.Finally, the webinar will provide an overview of suitable LECO analytical instruments for biofuel and SRF analysis. Instrument concepts, automation options, and practical laboratory considerations will be discussed, demonstrating how high analytical performance can be combined with efficiency and robustness in routine fuel testing.<blockquote>Presenter: Michael Jakob (Elemental Field Product Manager)</blockquote></div></div></div>

LECO: Analysis of the Key Parameters of Biofuels

Analysis of the Key Parameters of Biofuels

Analysis of biofuels and SRF using MVA, CHNS, calorific value, and ash fusion methods with modern LECO analytical instrumentation.

Advanced methodology for enhancing sample throughput through recent advances in Helium KED mode and complementary interference removal techniques.<blockquote>Presenter: Bert Woods (Application Scientist, Agilent Technologies, Inc.)Joined the Agilent ICP-MS team in 2004, with previous employment in the semiconductor industry with Dominion Semiconductor (IBM/Toshiba) and Micron. Bert is a 1997 Chemistry graduate of Radford University in Virginia and an avid Washington DC Sports fan.</blockquote>

Agilent Technologies: Atomic Spectroscopic webinars

Driving higher throughput through innovative QQQ ICP‑MS techniques

Advanced methodology for enhancing sample throughput through recent advances in Helium KED mode and complementary interference removal techniques.

Innovative QQQ ICP‑MS techniques

<h3>Real-Time Process Insights for Oil, Gas, &amp; Future Fuels with Raman Spectroscopy</h3><h4>A 5-Part Webinar Series</h4>As the energy sector shifts toward more complex and dynamic processes, real-time analytics are essential for maintaining control, efficiency, and product quality. This 5-part webinar series explores how process Raman spectroscopy and integrated measurement solutions enable fast, in-line analysis across oil &amp; gas, power generation, and emerging energy applications.<h5>What we'll cover:</h5>Each session highlights practical approaches to improving process visibility, reducing analytical delays, and supporting faster decision-making for:<ul><li>Natural gas</li><li>Refined fuels</li><li>Hydrogen</li><li>Sustainable aviation fuels</li><li>Carbon capture</li><li>Power generation</li><li>Emerging energy applications</li></ul><h5>This Series is Ideal For:</h5>Process, operations, and instrumentation professionals across oil &amp; gas, power generation, and emerging energy sectors, including engineers, plant and refinery managers, and technical specialists involved in process optimization and analytical measurement.<h5>Join the Webinars To:</h5><ul><li>Understand how real-time, in-line analytics improve process control and efficiency</li><li>Learn how process Raman simplifies and accelerates gas and liquid analysis</li><li>Explore alternatives to traditional methods such as gas chromatography</li><li>See how integrated measurement solutions enhance operational visibility</li><li>Gain insight into applications across conventional and next-generation energy systems</li></ul><h4>Webinar 5: Optimizing Future Fuel Processes with Process Raman Spectroscopy: Applications in Hydrogen, Sustainable Aviation Fuels &amp; Carbon Capture</h4>The global transition to future fuels, such as sustainable aviation fuel (SAF), hydrogen, and carbon capture, utilization and storage (CCUS), is reshaping how energy and chemicals are produced, monitored, and controlled. Real-time analytical technologies are becoming critical to ensure process efficiency, product quality, and regulatory compliance across these emerging applications. Process Raman spectroscopy enables in-line, non-destructive measurement of complex chemical systems with minimal sample preparation.By delivering rapid, data-rich measurements from a single scan, process Raman allows simultaneous quantification of multiple components in gases, liquids, and heterogeneous systems. This reduces reliance on slow, offline techniques and enables tighter process control and faster decision-making. The technology combines robust probe design, flexible sampling configurations, and seamless integration into industrial control systems. Its compact, field-deployable design allows deployment at multiple points from pilot to full-scale production.This webinar will discuss the application of process Raman spectroscopy in real-time monitoring of SAF production, hydrogen isomer conversations and CCUS applications.<blockquote>Speaker: Linxi Chen (Field Application Scientist, Thermo Fisher Scientific)</blockquote>

Thermo Fisher Scientific: Real-Time Process Insights for Oil, Gas, & Future Fuels with Raman Spectroscopy

Optimizing Future Fuel Processes with Process Raman Spectroscopy: Applications in Hydrogen, Sustainable Aviation Fuels & Carbon Capture

Join this webinar to discover how process Raman spectroscopy enables real-time analysis and process control for SAF, hydrogen, and CCUS applications.

Process Raman in Hydrogen, Sustainable Aviation Fuels

SpinPilot is Bruker’s next‑generation automation software for TopSpin, designed to simplify everyday NMR. In this webinar, we will introduce its intuitive web interface, profile‑based configuration, and secure user management. We will also show how typical NMR automation workflows translate to SpinPilot. This will help you run experiments faster and prepare your lab for future capabilities.SpinPilot brings a modern, browser‑based experience to NMR automation. You will see how profiles and roles separate instrument configuration from user management, enabling cleaner multi‑user setups. We will demonstrate queue and quota concepts, template‑driven experiment setup, and options for Python‑based customization.We will also highlight integration touchpoints with TopSpin 5 and discuss migration tips, training resources, and where to find updates. The session concludes with Q&amp;A.<h4>Key Learning Points:</h4><ul><li>Learn how SpinPilot’s modern, web‑based automation pairs with TopSpin 5</li><li>Configure profiles, roles, and BioSpin IAM for secure access</li><li>Standardize experiments with templates, queues, and quotas</li><li>Translate your IconNMR tasks seamlessly; extend with Python for advanced workflows and reporting</li><li>Plan a smooth migration with training materials, release highlights, and a live Q&amp;A, including timelines, support contacts, and resource links.</li></ul><blockquote>Speaker: Dr. Barbara Czarniecki (NMR Application Scientist at Bruker BioSpin)Barbara Czarniecki completed her DSc in Organometallic Chemistry at ETH Zurich, which following graduation, she continued to research and teach.&nbsp;</blockquote><blockquote>Speaker:&nbsp;Eric Johnson (Application scientist Bruker US)Dr. Eric Johnson earned his Ph.D. in Physics from the University of California, Berkeley, studying protein structures using NMR. He completed a postdoctoral fellowship at The Scripps Research Institute in La Jolla, where he investigated small‑molecule ligand–RNA interactions. In 2006, he joined the NMR Applications team at Bruker BioSpin and is based in the Bruker San Jose demo lab, where he specializes in all aspects of liquid‑state NMR.</blockquote><blockquote>Speaker:&nbsp;Robin Stein (Application scientist Bruker UK)Robin Stein holds a PhD from Cambridge University, where she specialised in solid-state NMR.&nbsp; Since then, she has been an applications scientist with Bruker UK Ltd, an applications service representative with Bruker Ltd (Canada), and an NMR manager at McGill University.&nbsp; Since 2022, she has been an applications scientist with Bruker UK Ltd.</blockquote>

Bruker: SpinPilot – The Future of NMR Automation

SpinPilot – The Future of NMR Automation

Master NMR automation with Bruker SpinPilot. Explore profile-based configurations, experiment queues, and Python customization for TopSpin 5 workflows.

Discover how today’s advanced peptide technologies are shaping tomorrow’s research, development, and manufacturing success.<h5>In this symposium, you'll learn about:</h5><ul><li>Scalable peptide API manufacturing and purification expertise for GLP‑1 class molecules</li><li>Label‑free, real‑time cell‑based bioassays for peptide activity, optimization, and safety testing</li><li>Non‑destructive Raman raw material identification through opaque containers to streamline GMP workflows</li><li>Inert LC/MS strategies for enhanced peptide separation, impurity profiling, and molecular weight confirmation</li></ul>This digital symposium explores the innovations shaping the future of peptide‑driven science, featuring modern analytical tools across cell analysis, chemistries, spectroscopy, and mass spectrometry. Experts will reveal practical approaches for integrating these technologies to strengthen and streamline peptide analysis.Attendees will gain a clear view of emerging technologies and practical strategies across modern research and applied science. Join the symposium to discover how to connect these advances directly to your own work.10:00 - 10:05 - IntroVitan Blagotinsek, Agilent Technologies10:05 - 10:20 - Highlight Talk - Scaling the GLP-1 Surge: Peptide API Development, Purification and Manufacturing at AATWolfgang Schiek, BioVectraAs the paradigm shift in diabetes management and the surge in anti-obesity drug sales and development are propelling unprecedented demand for complex peptide APIs therapies, reliable high quality peptide API manufacturing and purification are critical. Agilent Advanced Therapeutics provides specialized expertise and scaling capacity for these GLP-1 Agonists. We support our customers from preclinical to commercial through swift, customer-focused implementation in state-of-the-art facilities and are continuously expanding capabilities, true to our commitment: Invested in Science, Invested in You!10:20 - 11:05 - Talk 1: Accelerating Synthetic Peptide Discovery, Quality Control, and Safety Testing with xCELLigence BioassayLeyna Zhao, Agilent TechnologiesSynthetic peptides and proteins are rapidly emerging as important therapeutic modalities, driving the need for robust approaches to evaluate biological activity, product quality, and safety throughout development. In this webinar, we will explore how Agilent’s label free xCELLigence Real Time Cell Analysis (RTCA) platforms can support synthetic peptide discovery, quality evaluation, and safety testing through functional, cell based bioassays. Selected case studies will highlight the use of real time, kinetic cellular readouts in peptide discovery and optimization workflows. Evaluation criteria for biological products will be reviewed in the context of ICH Q6B specifications, with emphasis on the role of bioassays in assessing biological activity. In addition, examples of toxicity testing using xCELLigence RTCA—including published vaccine related applications—will demonstrate how real time cell based assays can provide sensitive and reproducible QC results.11:10 - 11:50 - Talk 2: Unlocking Deeper Insights into Peptide Purity and Impurity Profiling with LC/MS for GLP-1 RA CharacterizationHolger Stalz, Agilent TechnologiesSynthetic Peptide therapeutics are reshaping the biopharma landscape, and GLP-1 receptor agonists are at the center of that momentum—raising the stakes for purity assessment and impurity profiling. Join this webinar to see how Agilent’s advanced LC/MS workflows help scientists tackle these challenges with greater confidence and efficiency. You’ll learn how the InfinityLab Pro iQ Plus LC/MSD enables reliable peptide purity confirmation, while the Agilent BioQTOF high-resolution LC/MS/MS system supports detailed sequence confirmation and impurity identification. We’ll also show how OpenLab CDS and MassHunter BioConfirm software simplify complex data interpretation, helping QC and R&amp;D teams move faster and make more confident decisions in peptide characterization.11:55 - 12:35 - Talk 3: Raman Spectroscopy in Peptide PharmaceuticalsJan Wuelken, Agilent TechnologiesRapid, non destructive raw material identification (RMID) through all types of packaging. Reliable identity verification of peptides, amino acids, protected building blocks, and excipients is a critical step in peptide manufacturing. The Agilent Vaya Raman Raw Material Identity Verification System is specifically designed to identify raw materials directly through non transparent and opaque containers, without opening the package. By leveraging Spatially Offset Raman Spectroscopy (SORS), Vaya minimizes interference from container walls, liners, and fluorescence. This enables fast and reliable identification through typical peptide pharma packaging, including plastic drums, paper and multi layer bags, FIBCs, and amber glass containers. The through container measurement capability eliminates the need for sampling, significantly reducing the risk of cross contamination and protecting operators from hazardous, highly potent, or sterile materials. At the same time, it streamlines workflows by reducing handling steps and operator exposure. Agilent Vaya supports high throughput, GMP compliant raw material testing, accelerates release to manufacturing, and helps ensure a secure, efficient supply of materials for peptide synthesis and downstream processing—from early development to commercial production.12:40 - 13:15 - Talk 4: Advanced Column Solutions to enhance your Peptide Analysis and Purification WorkflowsKatrien Sabbe, Agilent TechnologiesWhether you're optimizing existing methods or developing new ones, this session will equip you with the tools to streamline your peptide characterization and purification. LC analysis of peptides can be challenging due to their sensitivity to metal interactions within chromatographic systems, often leading to poor peak shape and reduced sensitivity. Agilent Altura HPLC columns with Ultra Inert technology overcome these challenges by minimizing metal-analyte interactions. We will illustrate how this innovation enhances resolution, reproducibility, and quantification in reversed phase and HILIC separations of therapeutic peptides such as GLP-1 receptor agonists. Furthermore we will explore preparative techniques and purification workflows, offering tips for achieving high purity and recovery in synthetic peptide purification.<blockquote>Presenter: Vitan Blagotinsek (EMEA Marketing Program Manager Bio/Pharma, Agilent Technologies)Vitan is the Agilent Marketing Manager for the Pharma and Biopharma markets across the EMEA region, covering a broad portfolio of all Agilent products with relevance to these markets. Prior to this role, he had started at Agilent as a Chromatography and Sample prep-focused Product Specialist targeting the Biopharma market in the DACH region. His scientific background is in Protein Biochemistry/Structural Biology. He graduated in Biochemistry from the University of Oxford in the UK and has a PhD from Marburg University in Germany (Department of Chemistry).</blockquote><blockquote>Presenter:&nbsp;Wolfgang Schiek (Director Business Development, BIOVECTRA, Agilent Technologies)Wolfgang is the BD Director Europe for Agilent Advanced Therapeutics, where he specializes in bespoke CDMO solutions and a chemist by profession. With a 25-year track record at industry leaders like Evonik, Cambrex, and Novasep in a variety of technical, commercial and strategic roles, he has helped numerous clients bridge the gap from drug development to successful market launch. For the past four years at AAT, he has focused on the cutting edge of biologics and peptides, serving as one of the primary forces behind the company’s GLP-1 programs.</blockquote><blockquote>Presenter: Leyna Zhao (Product Marketing Director, Agilent Technologies)Leyna is Product Marketing Director at Agilent Technologies, where she leads global strategy for cell analysis platforms, including xCELLigence Real-Time Cell Analysis (RTCA). With over 20 years of experience in molecular biology, immunology, and drug discovery, she bridges scientific innovation with market adoption. Her work focuses on advancing label-free, real-time technologies that support small molecule screening, immune cell function analysis, and predictive toxicology. She holds a PhD in Biochemistry and has been instrumental in aligning Agilent’s cell analysis solutions with emerging regulatory trends, such as non-animal testing methodologies.</blockquote><blockquote>Presenter: Jan Wuelfken (Product Specialist, Molecular Spectroscopy EMEA IDO, Agilent Technologies)Jan graduated from the University of Hamburg in 1997 with a thesis about NMR-based conformation analysis of an antimicrobial peptide and in 2001 with his PhD thesis about CD4-binding peptides as inhibitors for HIV infection. He joined Varian Inc. in 2001 as a sale representative for molecular spectroscopy and with the takeover of Varian by Agilent 2010 he became a product specialist for molecular spectroscopy in the Agilent International Distributor Organization (IDO). Today his responsibility is the full Agilent Molecular Spectroscopy Portfolio which is UV-Vis, UV-Vis/NIR, Fluorescence, FT-IR and Raman Spectroscopy.</blockquote><blockquote>Presenter:&nbsp;Holger Stalz (LCMS Product Specialist, Agilent Technologies )Holger has worked as a product specialist for LC/MS for Agilent in Austria and Switzerland since 2011. He leads a team of European BioPharma Specialists focusing on biopharmaceutical applications and has been coordinating the development of new analytical solutions and methods for protein therapeutics and oligonucleotide-based products.</blockquote><blockquote>Presenter:&nbsp;Katrien Sabbe (Biopharma Business Development Manager, Agilent Technologies)For more then 25 years Katrien has been working in the field of Chromatography Columns and Supplies, first at VWR International and later at Varian Analytical Instruments, which was acquired in 2011 by Agilent Technologies. Currently, she is the EMEA Biopharma Business Development Manager at Agilent Technologies Chemistries and Supplies Division.</blockquote>

BiteSizeBio: Innovations and Emerging Tools in Peptide Science

Innovations and Emerging Tools in Peptide Science

Explore advanced peptide technologies. Learn about GLP-1 API manufacturing, xCELLigence bioassays, through-container Raman RMID, and inert LC/MS workflows

Advanced Peptide Technologies and GLP-1 Analysis

As the market for recycled plastics continues to expand, manufacturers face growing issues in ensuring material quality and controlling production processes. This webinar introduces multifaceted analytical solutions designed to support quality assurance and process optimization in the use of recycled plastics.The three-part webinar covers analytical solutions for ensuring the quality, consistency, and process control of recycled plastics in food-grade PET applications, the evaluation of property changes in PC/ABS resins caused by differences in molding conditions, and a rapid and simple approach for quantifying the size and amount of microscopic foreign matter in recycled plastics. Through case studies using recycled PET resins, PC/ABS materials and recycled PET pellets, the sessions demonstrate how multifaceted analysis using various analytical instruments supports quality evaluation and reliable use of recycled plastics.<h5>Key Learning Objectives:</h5><ul><li>Learn how advanced analytical solutions support quality, consistency, and process control in recycled plastics.</li><li>Gain insight into the multifaceted evaluation of plastics, including property changes caused by differences in plastic molding conditions.</li><li>Explore practical approaches to material characterization, contamination detection, and rapid quantification of microscopic foreign matter.</li></ul><h5>Who Should Attend:</h5><ul><li>QA/QC Managers and Scientists&nbsp;</li><li>Analytical Laboratory Managers&nbsp;</li><li>Materials Scientists and Engineers&nbsp;</li><li>Manufacturing and Process Engineers</li></ul><blockquote>Speaker: Mohit Pradeep Dodhia (Director, Plastic Recycling, Dodhia Industries Ltd)Speaker: Yuzo Yamazaki (Assistant Manager, Application Specialist (MALDI), Shimadzu Corporation)Speaker: Hiroki Maeda (Assistant Manager, Application Specialist (Particle Characterization), Shimadzu Corporation)Speaker: Melissa O’Meara (Forensic Science Consultant, C&amp;EN Media Group)</blockquote>

C&EN: Recycled Plastics - Solutions for Quality and Process Control

Recycled Plastics: Solutions for Quality and Process Control

Ensure quality control in recycled plastics. Learn about analytical solutions for food-grade PET, PC/ABS molding properties, and contamination detection.

Recycled Plastics: Quality and Process Control

<h4>Learn about complete miniscope solutions for behavioral experiments</h4>In this webinar, Morgana Favero, MD, PhD., will highlight Bruker’s Inscopix miniscope solutions. Learn about miniscope technology, workflow strategies, experimental design, and the benefits of a global team of scientific consultants there to support you through your entire research project.&nbsp;This webinar discusses Inscopix’s streamlined calcium imaging workflow in freely moving animals, featuring their integrated solutions and global team of PhD-level scientific consultants dedicated to making data collection and analysis intuitive and straightforward.Originally developed for the initial mini1P series (nVista, nVoke, nVue), this ecosystem now includes next-generation tools, such as the nVista 2P (two-photon) miniscope and the Quartet 2.0 multisite imaging system, all under the Bruker umbrella since 2022.The webinar covers key workflow steps, such as lens and indicator selection, behavioral experiment design, and analytical tools, as well as demonstrates how dedicated consulting can accelerate your path to discovery.Whether you’re new to Inscopix or returning to explore the latest advancements and meet your support team, don’t miss this opportunity—register today!&nbsp;<blockquote>Presenter: Morgana Favero, MD, PhD (Director, Customer Experience and Applications at Bruker FM-I)Morgana Favero completed her graduate training in Italy and a postdoctoral fellowship at the Children’s Hospital of Philadelphia before joining Inscopix, now part of Bruker, in 2017. She currently leads the global Field Application and Support teams within the Inscopix division. Her scientific background spans motor and sensory behavior, epilepsy, and migraine, with over 20 peer‑reviewed publications from her academic career. At Inscopix, she has built and trained a global team of PhD‑level consultants who work closely with researchers to develop new applications and advance neuroscience research.</blockquote>

Bruker: From Neural Recording to Functional Insight: Accelerating Discovery with the Inscopix Integrated Workflow

From Neural Recording to Functional Insight: Accelerating Discovery with the Inscopix Integrated Workflow 

Streamline calcium imaging in freely moving animals with Bruker's Inscopix workflow. Discover next-gen miniscopes and data analysis tools.

Inscopix Miniscope Workflows for Neuroscience Research

Forced degradation studies (FDS) are an essential part of therapeutics development. FDS involve the application of stress conditions to therapeutic antibodies to identify Critical Quality Attributes (CQAs) resulting from changes to the antibody Higher-Order Structure (HOS).NMR, in combination with chemometrics tools provided by the BioHOS plugin in Mnova, was applied to analyze FDS data obtained for two different UCB molecules. The approach identifies pathways involving variations in the molecular correlation time, corresponding to changes in dynamics (e.g., aggregation or fragmentation), and resulting from pathways involving variations at the primary structure level, such as PTMsPrediction models were then built by using Partial Least Squares (PLS) analysis to predict the degradation pathway caused by the applied stressing condition.In this webinar, we will be presenting the results from our studies and showing how BioHOS allows to easily identify the NMR peaks driving the main variations, potentially providing a site-specific identification of molecular changes and enabling assessment of the criticality of the CQAs involved.<h4>Learning Points</h4><ul><li>How NMR combined with chemometric analysis can be applied to forced degradation studies (FDS) to distinguish different degradation pathways in monoclonal antibodies</li><li>How multivariate models such as PLS help link stressing conditions to changes in dynamics, aggregation, fragmentation, or primary-structure related modifications</li><li>How NMR-based fingerprinting and chemometric loadings can be used to trace degradation effects back to specific spectral regions, supporting higher order structure assessment</li></ul><h4>Who should attend</h4><ul><li>Scientists in analytical development, structural characterization, or biophysical analysis of biologics and biosimilars</li><li>QC, CMC, and comparability teams involved in forced degradation studies and higher‑order structure assessment</li><li>Researchers in pharma, food and beverage, and biotech working with NMR (or other spectroscopic techniques) and multivariate data analysis for proteins or other macromolecules</li></ul><blockquote>Speaker: Giorgia Manzo (Senior Scientist in the Biophysical Characterization Team, UCB)Giorgia studied Biology at the University of Cagliari before completing a PhD in Biophysics on the characterization of antimicrobial peptides with liquid state NMR. After 5 years as post-doctoral researcher at King’s College London, Giorgia joined UCB in 2020 working in the Characterization team as spectroscopy expert. Besides being the reference person for NMR spectroscopy, her fields of expertise cover CD spectroscopy and SPR.</blockquote>

SciY: Structural Insights into mAb Degradation Pathways through Chemometrics‑NMR Synergistic Analysis

Structural Insights into mAb Degradation Pathways through Chemometrics‑NMR Synergistic Analysis

Combine NMR and chemometrics for mAb forced degradation studies. Learn to use PLS analysis in Mnova BioHOS to track antibody aggregation and structural changes

Chemometrics-NMR Analysis for mAb Forced Degradation Studies

<h4>From Galvanic Coating to Mine Tailings and Catalyst Recovery</h4>Elemental analysis of liquids, slurries, and sludges often involves specific challenges arising from sample heterogeneity, particle sedimentation, and matrix effects. Yet, obtaining reliable results fast &amp; easy is essential for industrial processes such as galvanic coating, chemical processing, mining tailings management, and industrial wastewater treatment.Join us for a free, 60‑minute online seminar to learn how smart X‑ray fluorescence (XRF) solutions can help. The session will feature real‑world application examples, live instrument demonstrations, practical sample‑preparation tips, and an interactive Q&amp;A with our experts.<blockquote><a target="_blank" rel="noopener noreferrer" href="https://www.bruker.com/en/news-and-events/webinars/2026/xrf-elemental-analysis-of-liquids-and-slurries.html#register">Register now to gain insights you can apply immediately.</a></blockquote><h4>Application Examples &amp; Learning Objectives:</h4><ul><li>Galvanic plating and coating solutions</li><li>Sludges from mine tailings &amp; sewage</li><li>Catalyst residues in industrial wastewater</li><li>Crude vegetable oil and used cooking oil for biofuel</li><li>Sample preparation strategies and best practices&nbsp;</li><li>Comparison of EDXRF and WDXRF solutions</li></ul><blockquote>Speaker: Dr. Kai Behrens (Head of XRF Product Line Management, Bruker AXS)Speaker: Dr. Adrian Fiege (Product Manager XRF, Bruker AXS)Speaker: Frank Portala (Product Manager XRF, Bruker AXS)Speaker: Renata Janjic (Application Scientist XRF, Bruker AXS)</blockquote>

Bruker: Elemental Analysis of Liquids and Sludges by XRF

Elemental Analysis of Liquids and Sludges by XRF

Discover XRF solutions for elemental analysis of liquids, slurries, and sludges with applications in mining, plating, wastewater, and biofuels.

Effective gene therapies require a thorough understanding of your delivery vehicle. Is it the right size? Does it contain an intact capsid, payload, and surface markers? Classic characterization methods don’t give structural insights, only look for a single component, and require purified samples to get actionable results. With the rise of in vivo CAR-T cell therapies, viral vectors have become increasingly complex to target the right cells and deliver cargo at the right time. Researchers need flexibility to adapt their characterization to the rapidly changing strategies for specified cell targeting and efficient gene delivery.Leprechaun is the only platform to deliver the complete biophysical ins and outs of individual lentivirus particles, with any combination of surface markers, at any stage from cell harvest to final stage, purified. Leprechaun combines interferometry and multi-channel fluorescence using a maximum of 25 µL of lentivirus, to characterize up to 16 samples in as little as a few hours. By assessing quality of lenti preps earlier in development, Leprechaun helps researchers obtain the most structurally intact lentivirus.In this webinar, we'll cover how Leprechaun delivers both sizing and structural data on lentivirus particles throughout purification and pinpoint steps for optimization. We’ll show how Leprechaun goes beyond ELISA and qPCR to provide additional insights by measuring multiple parameters on the same sample. Additionally, we’ll show some unique assays to measure breakout CAR expression to make sure your lenti is ready for in vivo CAR-T action. All these results showcase how Leprechaun is the go-to tool for complete biophysical characterization of lenti being developed for in vivo CAR-T cell therapies. &nbsp;<blockquote>Presenter:&nbsp;Brian Haldeman (Product Manager, Leprechaun, Unchained Labs)</blockquote>

Unchained Labs: Know the ins and outs of your lentivirus with Leprechaun 

Know the ins and outs of your lentivirus with Leprechaun

Characterize lentivirus particles for in vivo CAR-T cell therapies. Learn how Leprechaun delivers biophysical insights on sizing and surface markers

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