The leaflet outlines the role and handling of analytical equipment and systems in the process of a laboratory dealing with the analysis of chemical elements and molecules. It is an introduction to topics being considered by the Eurachem Analytical Equipment and Systems Qualification Working Group.&nbsp;Various steps are required to draw a conclusion concerning the object being examined (sampling target), see Fig. 1. The core part, the analytical measurement, is based on an analytical principle. The measurement is based on a physical or chemical interaction, e.g. between light of a certain wavelength and the sample, which leads to a displayed measured value. This measurement is carried out using analytical equipment. This equipment must be fit for its intended use. Complex analytical equipment with extensive data processing is referred to as a system. Analytical equipment is used to perform the analytical method. The method must be validated to demonstrate that it is fit for purpose.&nbsp;<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Eurachem_Fig_1_Analytical_principle_method_and_procedure_1_b751d25236.jpg" alt="Eurachem: Fig. 1 Analytical principle, method and procedure [1]" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Eurachem_Fig_1_Analytical_principle_method_and_procedure_1_b751d25236.jpg 245w," sizes="100vw" width="841" height="439"><h4>The pyramid of quality&nbsp;</h4>The pyramid of quality (Fig. 2) covers the analytical method. In order to produce a reproducible, reportable result that is suitable for the intended purpose, the equipment (system) (1st level) and analytical method (2nd level) must be well defined and under control, qualified or validated, respectively.&nbsp;<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Eurachem_Fig_2_Pyramid_of_quality_979312ac6b.jpg" alt="Eurachem: Fig. 2 Pyramid of quality" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Eurachem_Fig_2_Pyramid_of_quality_979312ac6b.jpg 163w," sizes="100vw" width="708" height="677">The equipment must have similar performance when carrying out the analyses as when developing and validating the method. Particularly in the case of methods based on libraries or training datasets, the long-term stability of the equipment must be ensured. In the case of transfer of the method to other equipment, both sets of equipment must have similar performance.&nbsp;The performance of the equipment and the behaviour of the method are monitored by quality control measures. This is the purpose of the internal or short term (3rd level) and inter-laboratory or long term (4th level) quality assurance. When selecting the quality assurance elements, the findings from levels 1 and 2 are taken into account.&nbsp;<h4>Is "calibration" sufficient?&nbsp;</h4>All relevant quality assurance systems, e.g. those meeting the requirements of ISO/IEC 17025 [2] and related standards, require equipment and systems to be traceably calibrated. But is that enough to prove the fitness for the intended use of the analytical equipment?&nbsp;According to the definition in VIM [3] calibration is the operation that, under specified conditions, establishes a relation between the quantity values with measurement uncertainties provided by measurement standards and corresponding indications with associated measurement uncertainties. It is implicitly assumed that the influencing quantities (e.g. ambient conditions, temperature, flow rates, intensities of signal sources, etc.) are constant and do not exhibit any short or long-term fluctuations or drifts. This assumes that no changes occur due to influencing quantities.&nbsp;Nevertheless this is not the case in everyday analytical work. The influence of fluctuations or changes in the influencing quantities is evaluated through robustness investigations during method development and validation. The magnitude of the fluctuations or deviations of the equipment is specified and verified during equipment qualification.&nbsp;<h4>The Fitness for Intended Use&nbsp;</h4>The life cycle (Fig. 3) of new equipment to be purchased by the laboratory begins with the definition of the requirements and the intended use of the equipment.&nbsp;<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Eurachem_Fig_3_Equipment_or_system_lifecycle_2919ea802d.jpg" alt="Eurachem: Fig. 3 Equipment or system lifecycle" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Eurachem_Fig_3_Equipment_or_system_lifecycle_2919ea802d.jpg 186w," sizes="100vw" width="887" height="742">The User Requirement Specifications (URS) define the selection criteria and the operational ranges of the equipment parameters (influence variables), e.g. flows, temperatures, analysis volumes, etc. Considerations to support data integrity and traceability are also included in the URS. For more complex systems, the interfaces and compatibility of the components are essential.&nbsp;All considerations made in this phase have an impact on the entire life cycle, i.e. right through to decommissioning. The stability and variability of the influence variables are monitored over the entire service life.&nbsp;In most cases, data and metadata should remain accessible and analysable beyond the end of the equipment's life. The laboratory must use its resources as sparingly and sustainably as possible. This includes the expected service life and the costs incurred. Data integrity considerations (ALCOA+ = Attributable, Legible, Contemporaneous, Original, Accurate, + Complete, Consistent, Enduring, Available) play a role during operation and at the end of life. These include paper records and electronic records.&nbsp;In the pharmaceutical industry, qualification of equipment and thus ensuring that analytical equipment and systems are suitable for the intended use, is mandatory, and the respective processes are often clearly defined. Specifications are also comprehensively defined for various equipment classes.&nbsp;The ISO standards, in particular ISO 9001 [4], ISO 10012 [5], ISO/IEC 17025 [2], ISO 17034 [6] or ISO/IEC 17043 [7], cover a very large area and a wide range of sectors. For specific sectors, an interpretation of the standards is required. Eurachem guides cover requirements for analytical chemistry and related disciplines. The Analytical Equipment and Systems Qualification Working Group is therefore developing guidance on establishing the fitness for intended use of analytical equipment and systems aimed at these disciplines.

Fitness for the intended use of analytical equipment and systems

In the week from March 23, the following webinars await you in the field of atomic and molecular spectroscopy and spectrometry<blockquote><h4><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/webinars">👉 DETAILS AND REGISTRATION IN THE WEBINARS SECTION</a></h4>👉 Search and filter in the largest global database with over 5 500 GC, LC, MS and spectroscopy webinars.</blockquote><h5>1. Anton Paar: Achieving Reliable Viscosity Results in Daily Lab Work</h5><ul><li>Tu, 24.3.2026 11:00 CET</li><li><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/webinar/6017">Registration</a></li></ul>Join this free Anton Paar webinar to find out how to choose the right setup, avoid common measurement mistakes, and improve reproducibility in your lab viscosity measurements.<h5>2. Bruker: Illuminating Brain Function through Two-Photon Microscopy: Calcium and Voltage Dynamics with Optogenetics</h5><ul><li>Tu, 24.3.2026 17:00 CET</li><li><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/webinar/6014">Registration</a></li></ul>Discover advances in two-photon microscopy in this webinar featuring Bruker’s Ultima 2Pplus system and modules for 3D optogenetics, voltage imaging, fast volumetric imaging, and mesoscale neuroscience research.<h5>3. Agilent Technologies: How can MassHunter software help you when you need help with your ICP-MS?</h5><ul><li>Tu, 24.3.2026 20:30 CET</li><li><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/webinar/6042">Registration</a></li></ul>Learn how MassHunter® software tools can streamline ICP-MS troubleshooting, method development, and proactive maintenance to reduce downtime and improve analytical performance.<h5>4. Thermo Fisher Scientific: Hypulse Surface Analysis System Demonstration</h5><ul><li>We, 25.3.2026 14:00 CET</li><li><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/webinar/6028">Registration</a></li></ul>We will introduce the Thermo Scientific Hypulse Surface Analysis System and demonstrate how it can be used to go beyond the limits of ion beam depth profiling.<h5>5. Bruker: Unlocking BioAFM Performance: From Sample Preparation to Advanced Accessories</h5><ul><li>We, 25.3.2026 17:00 CET</li><li><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/webinar/6015">Registration</a></li></ul>Learn best practices for atomic force microscopy (AFM) in this webinar covering sample preparation, advanced imaging modes, environmental control, and AI-enabled features that expand AFM capabilities.<h5>6. SPECTRO Analytical Instruments: Grade Search or Grade Control: Choosing the Right Method for Reliable Metal Verification</h5><ul><li>Th, 26.3.2026 16:00 CET</li><li><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/webinar/6024">Registration</a></li></ul>Learn how to prevent alloy mix-ups using PMI strategies. Discover when to apply grade identification or verification, and explore real workflows with mobile OES, handheld XRF, and structured metal databases.<h5>7. LECO: Solving Aluminum Challenges with Modern Characterization Tools</h5><ul><li>Th, 26.3.2026 16:00 CET</li><li><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/webinar/5939">Registration</a></li></ul>Learn how GD-OES, metallography, and hydrogen analysis combine to evaluate aluminum alloy quality, detect defects, and improve processing consistency in high-performance manufacturing.<h5>8. Mettler-Toledo: Thermal Analysis for Safety Evaluation of Chemical Processes</h5><ul><li>Th, 26.3.2026 16:00 CET</li><li><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/webinar/5735">Registration</a></li></ul>Join this webinar to explore how thermal analysis helps identify thermal hazards, improve process safety, and prevent runaway reactions in chemical production.

Webinars LabRulezICPMS Week 13/2026

This study presents a novel thiosemicarbazone-functionalized sorbent for ultrasound-assisted dispersive microsolid phase extraction of Cu(II), Cd(II), and As(III) from environmental and food samples. The method, coupled with ICP-OES, demonstrated high sensitivity, low detection limits, and reliable performance in irrigation water, soil, and tomato matrices.Density functional theory calculations and molecular docking analyses further explored the ligand’s electronic properties and potential antimicrobial activity. The integrated approach highlights the multifunctional applicability of the sorbent for trace metal monitoring and prospective biomedical research.<blockquote><h4>The original article</h4><h4><a target="_blank" rel="noopener noreferrer" href="https://pubs.acs.org/doi/10.1021/acsomega.5c08559">UA-DMSPE Determination of Cu(II), Cd(II), and As(III) in Water, Soil, and Tomato Using a Novel Thiosemicarbazone Sorbent: ICP-OES Performance with DFT Characterization and Antimicrobial-Target Docking</a></h4>Serkan Öncüoğlu*ACS Omega 2026, 11, 1, 1213–1235<a target="_blank" rel="noopener noreferrer" href="https://doi.org/10.1021/acsomega.5c08559">https://doi.org/10.1021/acsomega.5c08559</a><h6>licensed under <a target="_blank" rel="noopener noreferrer" href="https://creativecommons.org/licenses/by/4.0/">CC-BY 4.0</a></h6></blockquote>Selected sections from the article follow. Formats and hyperlinks were adapted from the original.<div>Heavy metals such as Cu(II), Cd(II), and As(III) pose significant threats to both the environment and human health due to their toxicity, bioaccumulation potential, and persistence in ecosystems. Especially cadmium and arsenic, even at trace concentrations, are known to exert nephrotoxic, neurotoxic, and carcinogenic effects through long-term exposure. <a href="javascript:void(0);">(1−6)</a> Therefore, their accurate, sensitive, and selective determination in natural and drinking water sources is one of the critical challenges in environmental monitoring. Although spectroscopic techniques such as ICP-OES and ICP-MS offer high sensitivity, the ultratrace levels of these metals in complex environmental matrices necessitate effective preconcentration strategies to ensure reliable quantification. <a href="javascript:void(0);">(7−10)</a> Among various sample preparation techniques, dispersive microsolid-phase extraction (DMSPE) has gained considerable attention due to its rapid phase interaction, low solvent consumption, and elimination of elution steps. <a href="javascript:void(0);">(11−21)</a>In addition to aquatic matrices, the accumulation of heavy metals such as Cu(II), Cd(II), and As(III) in soil poses serious ecological and agricultural threats. <a href="javascript:void(0);">(22−24)</a> However, the accurate determination of heavy metals in soils is complicated by strong adsorption to heterogeneous mineral phases, binding to humic substances, and site-specific variability, all of which can obscure true analyte concentrations and hinder reproducibility. Vegetables cultivated in metal-contaminated soils such as tomatoes can absorb these elements and introduce them into the human food chain either directly or through animal-derived products. This exposure route may result in severe health effects, including gastrointestinal and respiratory disorders, liver toxicity, and even cancer. <a href="javascript:void(0);">(25−27)</a> Moreover, the trace metal balance in soil, including essential elements such as Zn, Fe, and Cu, significantly affects plant health and crop productivity. While micronutrients are vital for growth, excessive levels of certain metals (e.g., Al, Fe) may negatively impact soil fertility. <a href="javascript:void(0);">(28−32)</a> Hence, trace metal analysis in soil is crucial not only for toxicological assessment but also for sustainable agricultural practices. <a href="javascript:void(0);">(33−35)</a>Plant-based matrices, particularly edible vegetables, are also valuable indicators of environmental contamination. Nevertheless, accurate monitoring in plant tissues remains challenging due to multistep pretreatment requirements (washing, drying, grinding, digestion) and the high organic content of the matrix, which can cause spectral interferences and analyte loss during preparation. Major elements like Ca, K, and Mg, along with trace essential elements such as Fe, Zn, Mn, Cu, and Se, are vital for human metabolism. <a href="javascript:void(0);">(36−39)</a> However, their excess or deficiency may lead to various disorders, and toxic elements such as Cd, Pb, As, and Hg can pose serious health risks even at very low concentrations. <a href="javascript:void(0);">(40−44)</a> Inductively coupled plasma optical emission spectroscopy (ICP-OES) remains a leading technique for elemental analysis in plant samples due to its multielement detection, broad linear range, and low detection limits. <a href="javascript:void(0);">(45−49)</a> Yet, accurate analysis of solid plant matrices like vegetables requires multistep sample preparation including washing, drying, grinding, acid digestion, and filtration before instrumental measurement. <a href="javascript:void(0);">(50)</a> In line with the principles of green analytical chemistry, recent efforts focus on minimizing reagent use, simplifying procedures, and improving environmental sustainability in such analytical workflows. <a href="javascript:void(0);">(51−54)</a>A critical factor in DMSPE is the selection of a suitable chelating agent that offers fast complexation, aqueous solubility, and stability over a wide pH range. In this context, thiosemicarbazones (TSCs) have emerged as highly effective ligands due to their polydentate nature and versatile coordination behavior, especially toward soft metal ions such as Cu(II), Cd(II), and As(III). <a href="javascript:void(0);">(55−65)</a> Literature reveals that TSC ligands not only improve analytical performance in metal extraction but also display significant biological activities including antibacterial, antifungal, antituberculosis, and anticancer properties. <a href="javascript:void(0);">(66−68)</a> Moreover, the incorporation of nitrogen-containing heterocycles, such as pyrazole rings, into TSC structures has been shown to enhance both coordination capacity and pharmacological potential. <a href="javascript:void(0);">(69)</a> These structural features increase cell membrane permeability and biological target interaction, broadening their application in medicinal chemistry. <a href="javascript:void(0);">(70−76)</a> TSC-based metal complexes, particularly with Cu(II), Ni(II), Co(II), Pt(II), and Ru(II), have exhibited promising results against various bacterial strains and tumor cell lines. <a href="javascript:void(0);">(77−79)</a>Recent studies have also demonstrated the potential of nanoparticle-functionalized sorbents such as Fe3O4 magnetic cores coated with poly(8-hydroxyquinoline) for the selective and efficient extraction of Cu(II) from complex matrices like soil, tomato, and water samples. <a href="javascript:void(0);">(80)</a> These materials offer excellent surface area, tunable selectivity, and low detection limits, while their magnetic responsiveness facilitates rapid separation without centrifugation. <a href="javascript:void(0);">(81−84)</a> The selection of water, soil, and tomato matrices was made to encompass distinct yet complementary exposure pathways: water as a direct route for both human consumption and agricultural applications, soil as the principal environmental reservoir and source of contamination, and tomato as a representative edible crop widely consumed for its capacity to accumulate trace metals from contaminated soils.In this study, I report the synthesis and structural characterization of a novel thiosemicarbazone derivative not previously described in the literature. The synthesized ligand was covalently immobilized onto a silica-based sorbent and applied in the UA-DMSPE procedure for the selective extraction and enrichment of Cu(II), Cd(II), and As(III) from environmental water, soil, and tomato samples, followed by quantification via ICP-OES. In this regard, the UA-DMSPE approach developed in this study minimizes sample handling steps, reduces matrix interferences, and enhances recovery efficiency, thereby addressing many of the limitations commonly associated with soil- and plant-based matrices. The novelty of this work lies in combining a newly designed TSC derivative with UA-DMSPE to achieve a high recovery at trace levels with improved reproducibility. Furthermore, the integration of DFT calculations and docking studies provides a unique interdisciplinary perspective, reinforcing both the environmental monitoring applications and the potential biomedical relevance of the ligand.<h4>Experimental Section</h4>The structural characterization of the synthesized compound was carried out using 1H NMR spectroscopy on a high-resolution Bruker WH-400 Fourier Transform NMR spectrometer. FTIR spectra were recorded by using a PerkinElmer Spectrum BX-II instrument. Elemental compositions (C, H, N, and S) were determined by using a LECO CHNS-O-9320 elemental analyzer. Surface morphology and elemental composition of the sorbent were examined by scanning electron microscopy (SEM) coupled with energy-dispersive X-ray spectroscopy (EDX), using a Zeiss Evo HD15 system equipped with a tungsten electron source.Ultrasound-assisted extraction procedures were performed in a Bandelin ultrasonic bath. Ultrapure water utilized throughout the experiments was supplied by a Thermo Scientific Smart2Pure Pro system. Quantitative analysis of metal ions was conducted by using a <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/library?mainauthorItems=10&amp;search=Varian+710-ES">Varian 710-ES</a> inductively coupled plasma optical emission spectrometer (ICP-OES). The emission wavelengths employed for the determination of Cu(II), Cd(II), and As(III) were 324.75, 228.80, and 193.70 nm, respectively.<h4>Results and Discussion</h4><h5>Characterization of Si-Carb-Formazan</h5>Structural characterization of the synthesized silica-based sorbent modified with a thiosemicarbazone (TSC) ligand was conducted by using FTIR spectroscopy and SEM-EDX analyses. As illustrated in <a target="_blank" rel="noopener noreferrer" href="https://pubs.acs.org/doi/10.1021/acsomega.5c08559#fig3">Figure 3</a>, the FTIR spectra provided clear evidence for the presence of both the silica support and the organic ligand. In the spectrum of unmodified silica (red), a broad absorption around 3436 cm–1 was attributed to O–H stretching vibrations of surface silanol groups, while a distinct peak near 1090 cm–1 indicated the asymmetric stretching of Si–O–Si bonds. Additional bands between 966 and 808 cm–1 were assigned to bending vibrations associated with Si–O and Si–OH functionalities.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/ACS_Omega_2026_11_1_1213_1235_Figure_3_Comparative_FTIR_spectra_of_the_TSC_ligand_36aed1fecd.jpg" alt="ACS Omega 2026, 11, 1, 1213–1235: Figure 3. Comparative FTIR spectra of the TSC ligand (black), functionalized silica material (blue), and unmodified silica (red) are shown from top to bottom, respectively." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_ACS_Omega_2026_11_1_1213_1235_Figure_3_Comparative_FTIR_spectra_of_the_TSC_ligand_36aed1fecd.jpg 245w," sizes="100vw" width="2088" height="1265">The pure TSC ligand spectrum (black) revealed a broad band at 3429 cm–1, corresponding to N–H stretching vibrations. A strong absorption at 1542 cm–1 confirmed the presence of the imine group (C═N), a key structural feature of the TSC. Moreover, the peaks at 2956 and 2771 cm–1 were consistent with aliphatic C–H stretching modes, and the range between 1248 and 1018 cm–1 showed characteristic C–N stretching vibrations.In the spectrum of the functionalized silica material (blue), absorption features from both the silica matrix and the organic ligand were observed, indicating successful covalent grafting. The persistent presence of the imine C═N band at 1543 cm–1 demonstrated that the TSC retained its structural identity postimmobilization. The broad signal at 3426 cm–1 suggested overlapping of the O–H and N–H stretching vibrations from the silica and the ligand moieties. Furthermore, the intense band at 1109 cm–1 confirmed the structural integrity of the silica framework through Si–O–Si vibrations, and the peaks at 2962 and 2770 cm–1 supported the presence of aliphatic C–H groups associated with the ligand. Altogether, these spectroscopic observations conclusively verified the successful functionalization of the silica surface with the TSC ligand via chemical bonding interactions.Morphological and elemental characteristics of the TSC-functionalized silica sorbent were evaluated both before and after metal ion adsorption using scanning electron microscopy (SEM), energy-dispersive X-ray spectroscopy (EDX), and elemental mapping techniques. As depicted in <a target="_blank" rel="noopener noreferrer" href="https://pubs.acs.org/doi/10.1021/acsomega.5c08559#fig4">Figure 4</a>, the SEM micrograph obtained prior to metal binding revealed a relatively uniform and porous surface topology. Following the adsorption process, noticeable morphological changes were observed, including increased surface roughness and particle agglomeration, indicating the interaction between the sorbent and metal ions.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/ACS_Omega_2026_11_1_1213_1235_Figure_4_SEM_images_and_EDX_spectra_of_the_sorbent_before_and_after_metal_sorption_81e625a900.jpg" alt="ACS Omega 2026, 11, 1, 1213–1235: Figure 4. SEM images and EDX spectra of the sorbent before and after metal sorption." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_ACS_Omega_2026_11_1_1213_1235_Figure_4_SEM_images_and_EDX_spectra_of_the_sorbent_before_and_after_metal_sorption_81e625a900.jpg 170w," sizes="100vw" width="2088" height="1916">Furthermore, EDX spectral analysis of the pristine sorbent confirmed the presence of only silicon (Si) and oxygen (O), consistent with the silica matrix. However, after exposure to metal-containing samples, new peaks corresponding to arsenic (As), cadmium (Cd), and copper (Cu) appeared in the EDX spectrum, demonstrating that these metal ions were successfully captured by the sorbent. Complementary EDX mapping further confirmed that these metal ions were uniformly distributed across the surface of the material, providing visual evidence of effective and homogeneous adsorption. Collectively, these findings validate the selectivity and efficiency of the prepared sorbent for the adsorption of As(III), Cd(II), and Cu(II) ions from complex matrices.C12H12BrN3S2: Calc. %C: 42.11; H, 3.53; N, 12.28; S, 18.73. Found: %C: 41.81; H, 3.42; N, 12.17; S, 18.75. FTIR (KBr pellet) ν/cm–1 3429 (N–H), 1542 (C═N), 1124 (N–N), 839 (C═S), 792 and 725 (thiophen and phenyl ring stretching). 1H NMR (400 MHz, DMSO-d6) data [δ 11.14 (s, 1H), 8.33 (s, 1H), 7.97–7.89 (m, 2H, ArH), 7.50–7.39 (m, 2H, ArH), 3.23 (s, 6H, N(CH3)2)] are correctly cited as <a target="_blank" rel="noopener noreferrer" href="https://pubs.acs.org/doi/10.1021/acsomega.5c08559#fig5">Figure 5</a>, whereas the 13C NMR (100 MHz, chloroform-d) data [δ: 173.89, 143.82, 137.17, 134.85, 131.50, 127.95, 125.69, 125.57, 122.63, 116.97, 40.18 (2 × C)] are cited as <a target="_blank" rel="noopener noreferrer" href="https://pubs.acs.org/doi/10.1021/acsomega.5c08559#fig6">Figure 6</a>.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/ACS_Omega_2026_11_1_1213_1235_Figure_5_1_H_NMR_spectrum_of_the_synthesized_thiosemicarbazone_TSC_ligand_79cb0c999e.jpg" alt="ACS Omega 2026, 11, 1, 1213–1235: Figure 5. 1H NMR spectrum of the synthesized thiosemicarbazone (TSC) ligand." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_ACS_Omega_2026_11_1_1213_1235_Figure_5_1_H_NMR_spectrum_of_the_synthesized_thiosemicarbazone_TSC_ligand_79cb0c999e.jpg 245w," sizes="100vw" width="2088" height="1096"><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/ACS_Omega_2026_11_1_1213_1235_Figure_6_13_C_NMR_spectrum_of_the_synthesized_thiosemicarbazone_TSC_ligand_8b3a4af07a.jpg" alt="ACS Omega 2026, 11, 1, 1213–1235: Figure 6. 13C NMR spectrum of the synthesized thiosemicarbazone (TSC) ligand." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_ACS_Omega_2026_11_1_1213_1235_Figure_6_13_C_NMR_spectrum_of_the_synthesized_thiosemicarbazone_TSC_ligand_8b3a4af07a.jpg 245w," sizes="100vw" width="2088" height="1037"><h4>Conclusions</h4>In this study, a novel thiosemicarbazone derivative was successfully synthesized and characterized using spectroscopic (FTIR, NMR) techniques. Its coordination behavior toward Cu(II), Cd(II), and As(III) ions was systematically investigated using the UA-DMSPE method, demonstrating high extraction efficiency and selectivity under optimized conditions. The method was effectively applied to real samples, including water, soil, and tomato matrices, highlighting its potential for environmental and food safety monitoring.Computational studies provided theoretical insights into the stability and electronic features of the ligand with DFT calculations supporting and rationalizing the experimentally observed donor–acceptor interactions. Molecular docking analyses revealed moderate but specific binding affinities of the ligand toward biologically relevant proteins, suggesting potential pharmacological relevance in addition to its analytical applications.Overall, the integration of synthesis, analytical validation, and computational modeling provides comprehensive insight into the multifunctional properties of this novel thiosemicarbazone derivative. The findings not only establish a reliable platform for trace metal monitoring in complex matrices but also open avenues for future investigations of thiosemicarbazones as dual-purpose ligands with both environmental and biomedical significance.</div>

UA-DMSPE Determination of Cu(II), Cd(II), and As(III) in Water, Soil, and Tomato Using a Novel Thiosemicarbazone Sorbent: ICP-OES Performance with DFT Characterization and Antimicrobial-Target Docking

Article

Webinars

Scientific article

Science and research

Eurachem is a European network promoting international traceability of chemical measurements and good analytical practice. It provides expert guidance, supports method validation, uncertainty evaluation, proficiency testing, and facilitates discussion on technical and policy issues in analytical quality.

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LabRulez

Metrohm

Anton Paar

Agilent Technologies

Milestone

Bruker

C&EN

<div><div id="inner_content_body_text" data-content-id="394785">Extensional deformation plays a crucial role in processes such as blow molding, film blowing, coating, and fiber spinning—applications where shear rheology alone falls short in characterizing material behavior.In this session, real measurements are used to visually give an understanding of the core concepts of extensional rheology. Examples of standard polymers will be used to explain measuring principles and techniques.Our measuring solutions, the SER cell and UXF cell, will be introduced, as well as current trends in extensional rheology. Participants will gain insights into choosing the appropriate setup based on their testing goals, whether for product development, competitive benchmarking, or quality control.Whether you’re new to rheology or looking to deepen your expertise, this webinar offers a compact yet comprehensive foundation in the elongational flow behavior of polymers.<blockquote>Presenter: Philana Kruse, M.Sc.Philana Kruse has a background in chemistry and plastics technology. As a research fellow at the chair for Plastics Technology, her academic work was centered around the rheological characterization of polymer materials. For the past two years she has been part of Anton Paar, where she supports customers in the field of polymer rheology with a focus on extensional testing methods.</blockquote></div></div>

Anton Paar: Extensional Rheology of Polymers: Air Bearing Rheometer Applications

Extensional Rheology of Polymers: Air Bearing Rheometer Applications

Explore extensional rheology of polymers, measuring principles, SER and UXF cells, practical applications in blow molding, film blowing, fibers.

Air Bearing Rheometer Applications

Sample preparation for elemental analysis is one of the most resource-intensive steps in the laboratory, involving aggressive acids, energy use, and significant waste generation. This webinar will show how Milestone’s sustainable innovations, and the GreenPrep MW Score, provide a clear, measurable framework for reducing environmental impact without compromising analytical quality. Through improvements in chemistry, technology, and workflow, laboratories can cut reagent consumption, lower energy per sample, extend vessel lifetime, and reduce gas waste. Attendees will learn practical strategies to adopt greener protocols and evaluate their own processes using objective sustainability metrics.<h4>Key Learning Objectives:</h4><ul><li>Understand the GreenPrep MW Score and how it provides an objective way to evaluate and benchmark sustainability in sample preparation.</li><li>Reduce environmental impact by adopting greener digestion chemistries that minimize acid volumes, waste, and operator exposure.</li><li>Leverage energy-efficient microwave technologies to lower energy consumption per sample while maintaining high digestion performance.</li><li>Enhance workflow sustainability through acid purification, automated reagent dosing, and cleaner, safer vessel-handling practices.</li></ul><blockquote>Speaker: Lorenzo Rossi (Application Specialist at Milestone)</blockquote>

Milestone: Sustainable Sample Preparation for Elemental Analysis: Practical Actions for a Greener Lab

Sustainable Sample Preparation for Elemental Analysis: Practical Actions for a Greener Lab

Sustainable sample preparation for elemental analysis, introducing Milestone GreenPrep MW Score, greener chemistries, and energy-efficient microwave digestion.

Sample Preparation for Elemental Analysis

<div>Learn about how Fourier-Transform Infrared (IR) and Electron Paramagnetic Resonance (EPR) spectroscopies enable in-depth understanding of polymer reactions. This webinar will review two main topics:<ul><li>The curing process of polymers and how FT-IR allows for real time monitoring of kinetics and degree of cure, with calibration protocols to measure conversion percentages.</li><li>The use of EPR spectroscopy to study radical mechanisms involved in polymerization, degradation, and stability of polymer materials.</li></ul><h4>Webinar Overview</h4>Polymers are an integral part of everyday life, from household goods to various fields of research and industrial applications. The ability to study the formation, degradation and stability of polymers is an important endeavor in the development of materials with better performance and longevity. Join us for this informative webinar on understanding the mechanisms and kinetics of various polymer processes via Fourier-Transform Infrared (FT-IR) and EPR Spectroscopy.The polymer curing process, from reaction kinetics to quantification of the process, is important to understand for new materials. FT-IR is highly suited for tracking the curing process due to its sensitivity to changes in functional groups We will showcase the ability of FT-IR in monitoring reaction kinetics and quantifying the degree of cure. Attendees will also gain technical insights into optimized workflows for R&amp;D and QA environments. &nbsp; Polymerization or degradation of polymer materials can often involve the formation of free radicals. The best suited method for unambiguous detection of free radicals in polymer processes is EPR Spectroscopy, which is a high-sensitivity, versatile and non-destructive technique. We will showcase the ease-of-use the Magnettech ESR5000 benchtop spectrometer and how users can incorporate workflows to identify radicals/impurities, track kinetics, and stress test polymer materials. &nbsp;&nbsp;<h4>What to Expect</h4>In this webinar, we will show how FT-IR and EPR methods provide valuable information during polymer formation and degradation processes. Learn how FT-IR can track reaction kinetics in real time and provide calibration procedures for the curing process. Dive into EPR as a robust, non-destructive technique for studying radical driven mechanisms in polymer materials under diverse conditions.<h4>Key Learning Points</h4>This webinar demonstrates how FT-IR and EPR are suitable for studying polymer reactions and kinetics under various conditions<ul><li>FT-IR workflows for kinetics of curing and quantifying degree of cure</li><li>Case studies using UV treated acrylates and calibration procedures for curing percentages</li><li>EPR for tracking free radical driven processes in polymer reactions, degradation and testing of polymers exposed to various stimuli</li></ul><h4>Who Should Attend?</h4><ul><li>Polymer chemists and researchers developing new materials</li><li>Industry professionals working with polymer materials looking to add screening tools to their workflows</li><li>Polymer scientists wanting to understand the radical mechanisms that drive processes such as polymerization or degradation</li></ul><blockquote>Presenter: Alvaro Montoya (Ph.D. in chemistry from the University of Florida, EPR Application Scientist, Bruker BioSpin)Alvaro Montoya began his EPR career as a Ph.D. student at the University of Florida after obtaining his B.S. in Chemistry from Susquehanna University. Early in his graduate career, he made use of CW and High Field EPR in studying the catalytic mechanisms of metalloenzymes. He then grew a profound appreciation for FT EPR and expanded his EPR toolbox for his research endeavors. After completing his Ph.D., Alvaro joined Bruker in January of 2023 working as an Applications Scientist.Presenter: Dr. Sergey Shilov (Product Manager, &nbsp;Bruker Optics)Dr. Sergey V. Shilov is a Product Manager for North America at Bruker Optics. Sergey joined Bruker in 2001. He is responsible for the support and development of new applications for the Bruker research FTIR systems. He received his Ph.D. in 1992 from the Russian Academy of Sciences in Polymer Physics and his M.S. from St. Petersburg State University (Russia) in Physics in 1986. Alexander Von Humboldt Foundation (Germany) awarded him a research fellowship in 1996. Sergey published 37 papers in peer-reviewed journals. His research interests include time-resolved FTIR spectroscopy, surface science, polymer, and life-science applications.&nbsp;</blockquote></div>

Bruker: Understanding Polymer Reactions and Degradation with FT-IR and EPR Spectroscopy

Understanding Polymer Reactions and Degradation with FT-IR and EPR Spectroscopy

Use FT-IR and EPR to study polymer curing, reaction kinetics, and radical mechanisms in polymerization and degradation.

Polymer Reactions with FT-IR and EPR Spectroscopy

Raman microscopy is widely used for chemical identification and chemical imaging, yet many real-world organic samples remain difficult to analyze with Raman. Biological tissues, cells, and environmental microplastic samples often exhibit strong fluorescence backgrounds, while weak scattering limits sensitivity. This can lead to researchers frequently encountering long acquisition times, uncertain particle identification, or datasets that lack the quality needed for confident interpretation and identification.Infrared spectroscopy is a powerful technique for chemical identification of organic samples but it has poor spatial resolution compared to Raman, tied to its much larger wavelengths. This webinar will discuss a breakthrough new sub-500nm IR spectroscopy technique called Optical photothermal IR spectroscopy (O-PTIR). O-PTIR provides chemical imaging and spectroscopy without fluorescence interference in seconds on organic samples such as microplastics and life sciences.This webinar will also discuss examples of simultaneous sub-micron IR and Raman spectroscopy, from the same sample region, such that the complementarity of IR and Raman without fluorescence interference in seconds as well as new laser-scanning based innovations for high-speed imaging for improved throughput. Application examples in microplastics characterization and life science research will demonstrate how challenging samples can be analyzed more reliably, how chemical specificity can be improved, and how multimodal workflows can provide actionable chemical information where traditional Raman imaging struggles.<h5>Key Learning Objectives:</h5><ul><li>Understand the fundamental limitations of Raman microscopy when analyzing samples such as microplastics and life science.</li><li>Learn about the new breakthrough O-PTIR technique that allows one to get sub-500nm spectra on organic samples with examples provided from microplastics and life sciences.</li><li>Discover how a combination of IR and Raman spectra obtained simultaneously and from the same sample location, can improve confidence in unknowns identification and provided, and also improved data quality.</li></ul><h5>Who Should Attend:</h5><ul><li>Microplastics and environmental researchers studying polymer particles in complex matrices</li><li>Cell and tissue biologists using chemical imaging or microscopy techniques</li><li>Biopharmaceutical scientists investigating subvisible protein particles, aggregates, and formulation stability</li><li>Raman microscopy and spectroscopy users encountering fluorescence or weak signal limitations</li><li>Polymer and materials scientists performing particle or surface characterization</li><li>Analytical chemists working with heterogeneous or challenging samples</li><li>Core facility managers and laboratory directors responsible for analytical instrumentation selection</li></ul><blockquote>Presenter: Andrew P. Ault (Professor, Department of Chemistry, University of Michigan)Presenter:&nbsp;Dr. Mustafa Kansiz (Director of Product Management, Photothermal Spectroscopy Corp)</blockquote>

C&EN: Overcoming Raman Microscopy Challenges in Microplastics and Life Sciences

Overcoming Raman Microscopy Challenges in Microplastics and Life Sciences

Webinar on O-PTIR spectroscopy combining sub-micron IR and Raman for microplastics, life sciences, and fluorescence-limited samples.

Raman Microscopy in Microplastics and Life Sciences

Conventional analysis of polymers requires several different technologies to determine parameters such as density, intrinsic viscosity, hydroxyl value, additive content, and more. These approaches are not only time-consuming but also require significant effort from qualified personnel, both in final quality control and monitoring criticial stages during the production process.In our upcoming webinar on April 16, we present NIR spectroscopy (NIRS) as a faster and easier alternative. This chemical-free technlogy provides results at the push of a button enabling the determination of multiple chemical and physical parameters with just one measurement within seconds.After a brief introduction to the fundamentals of NIRS, our experts will demonstrate how polymer manufacturers and processors can use this technology to simplify quality control, reduce waste, and use automation to improve overall efficiency. In a Q&amp;A session at the end of the webinar, our presenters will be happy to answer any questions you may have about NIRS and how to implement it in your manufacturing process.<h4>Key learnings of this webinar:</h4><ul><li>Understand what NIRS is and how it works</li><li>Understand how NIRS compares with traditional wet chemistry</li><li>Understand how NIRS is applied as per ASTM guidelines</li><li>Application examples for NIRS from the polymer sector</li></ul><h4>Who should attend?</h4>Lab managers, lab technicians, chemists, and everybody else interested in making their quality control of polymers more efficient.<blockquote>Presenter: Andreas Agerer (Application Specialist NIRS, Metrohm International Headquarters)Andreas Agerer is an Application Specialist at Metrohm AG, working in the Competence Center Spectroscopy since 2018. In this time, he has been responsible for developing NIRS methods tailored to new application areas and supporting sales teams during feasibility studies. Andreas completed his university graduate work in the field of polymer analysis using vibrational spectroscopy.Presenter:&nbsp;Dr. Maria Cartes (Product Specialist Spectroscopy, Metrohm International Headquarters)Dr. Maria Cartes studied chemistry. After finishing her PhD studies on ethylene polymerization at the University of Seville (Spain), she moved to Switzerland to work as a postdoc. In 2021, Maria joined Metrohm, where she works as Product Specialist in the Competence Center Spectroscopy, providing international support and product training for NIRS.</blockquote>

Metrohm: Measure smarter, spend less – NIR spectroscopy for polymer analysis

Measure smarter, spend less – NIR spectroscopy for polymer analysis

NIR spectroscopy for polymer quality control. Explore fast multi-parameter analysis and automation benefits for manufacturing efficiency.

NIR spectroscopy for polymer analysis

Accurate elemental analysis of organic matrices such as edible oils, biofuels, and renewable fuel feedstocks presents unique challenges due to their complex composition. This webinar provides a practical overview of setting up ICP-OES instrumentation for organic sample analysis, including key considerations for sample introduction, plasma conditions, and matrix handling. We will review method development strategies and share representative results to demonstrate performance and reliability in real-world applications.<blockquote>Presenter: Kristen Pisanko</blockquote>

Agilent Technologies: Atomic Spectroscopic webinars

Fueling Accuracy: ICP-OES Analysis for Organic Biofuel and Renewable Fuel Feedstocks

This webinar provides a practical overview of setting up ICP-OES instrumentation for organic sample analysis

ICP-OES for Organic Biofuel and Renewable Fuel

Spices are used to enhance flavor in food but can be grown or processed in contaminated environments. This poster discusses techniques for determination their heavy metals by ICP-OES and ICP-MS and the excellent agreement across both platforms.<blockquote>Presenter: Bert Woods (Application Scientist, Agilent Technologies, Inc.)Joined the Agilent ICP-MS team in 2004, with previous employment in the semiconductor industry with Dominion Semiconductor (IBM/Toshiba) and Micron. Bert is a 1997 Chemistry graduate of Radford University in Virginia and an avid Washington DC Sports fan.</blockquote>

Heavy Metal Elements in Food Spices: A Critical Analysis Using ICP-MS and ICP-OES Techniques

This sesson discusses techniques for determination heavy metals in food by ICP-OES and ICP-MS.

Heavy Metal Elements in Food Spices by ICP-MS & ICP-OES

REEs are typically present in wastewater at ultra-trace (ng/L) levels. Wastewater matrices are complex, often containing high levels of salts and organic matter that can cause matrix effects and spectral interferences. Doubly charged ions (M²⁺) from REEs like Nd²⁺, Sm²⁺, Gd²⁺ can interfere with monoisotopic analytes by appearing at half their mass-to-charge ratio (e.g., 150Nd²⁺ interferes with 75As⁺). These interferences are particularly problematic for elements like As, Se, Zn, and Ru. This presentation will discuss the mitigation and removal of the associated interferences for both single and triple quad ICP-MS.<blockquote>Presenter: L. Craig Jones (ICP-MS Application Scientist, Agilent Technologies, Inc.)Craig has been with Agilent for over 15 years as an ICP-MS applications scientist. He has been involved with multiple type of applications for ICP-MS, including environmental, pharmaceutical, semiconductor, geologic, and clinical analyses, to name a few. Previous to Agilent he worked in an environmental lab performing analysis and supervising both the inorganic and organic sections of the laboratory. In his spare time, Craig enjoys volunteering at the local marine science center, mountain biking, hiking, and relaxing at the beach. Craig obtained a Bachelor of Science degree in chemistry from Fort Lewis College in Durango, CO.</blockquote>

REE determination in waste water and effective doubly charged interference removal by ICP-MS

Webinar on managing REE interferences in wastewater by single and triple quadrupole ICP-MS, improving ultra-trace detection of As, Se, Zn, and Ru.

REE determination in waste water & removal by ICP-MS

Lithium-ion batteries are widely used in electronic devices due to their large capacity, high voltage, light weight, and lack of memory effects. The analysis of elemental impurities and composition in the entire supply chain is vital as it can impact the performance, safety, and lifespan of a battery. In this webinar we will discuss how to use a smart ICP-OES and an auto-dilutor to increase productivity and avoid common challenges such as spectral interferences, with these complex sample matrices.<blockquote>Presenter: Sima Singha, PhD (ICP-OES Application Scientist, Atomic Spectroscopy, Agilent Technologies, Inc.)Sima has over fifteen years of hands on experience as an applications scientist in the field of atomic spectroscopy. Before joining Agilent in 2017, managed an agricultural chemistry laboratory for the analysis of water, soil, and plant tissue digests using ICP-OES for various EPA methods. She received a Ph.D. degree in Chemistry from the University of Illinois at Chicago with numerous peer-reviewed publications.</blockquote>

Rapid Analysis of Elemental Impurities in Li-ion Battery Samples by an ICP-OES and an Autodilutor

Webinar on lithium-ion battery impurity analysis using ICP-OES and auto-dilution, focusing on spectral interferences, productivity, and robust workflows.

Analysis of Impurities in Li-ion Batteries by ICP-OES

<h4>Comprehensive nanoscale characterization of 2D materials using AFM</h4>Characterizing 2D materials involves examining a wide range of nanoscale structures properties, and chemistry. Atomic force microscopy (AFM) is extremely versatile, making it ideal for addressing these complexities. With AFM, researchers can investigate various aspects of 2D materials (often simultaneously), gaining detailed insights that are essential for advanced applications.<h5>Join us for this webinar to learn about:</h5><ul><li>Single-platform correlation of structure, properties, and chemistry</li><li>Commonly used AFM modes for 2D materials characterization</li><li>Manipulation modes for in-situ device fabrication by cutting, folding, or oxidation</li></ul>AFM plays a pivotal role in the nanoscale characterization of 2D materials by providing high-resolution topographical, mechanical, and electrical property mapping at the nanoscale, down to the atomic level. Identifying and characterizing single layers and multilayers is routine, while crystal orientation can often be determined with the proper choice of mode and probe. Since the AFM probe can act as a nanoscale electrode, it is possible to directly measure electrical properties of these materials at the relevant length scales between 1 and 100 nm. Photothermal AFM-IR (AFM-IR) adds localized chemical identification with nanometer scale spatial mapping by integrating infrared spectroscopy with AFM. Together, these capabilities correlate structure and chemistry, enabling comprehensive studies of complex 2D material systems. The AFM probe can also be used for nanomanipulation and nanolithography, allowing device fabrication by cutting, folding, or oxidation.<h5>In this webinar, we discuss:</h5><ul><li>Commonly used AFM modes for identification and characterization of 2D materials</li><li>Recent advancements in consistency of high-resolution 2D material mapping</li><li>Characterization of nanoelectrical properties in 2D materials through conductivity, impedance, and surface potential measurements</li><li>Nanoscale chemical identification through AFM-IR spectroscopy and mapping</li><li>Nanolithography on 2D materials, for example by tip-induced local anodic oxidation</li></ul>

Bruker: Advances in AFM for the Characterization of 2D Materials

Advances in AFM for the Characterization of 2D Materials

AFM for 2D materials characterization. Discover nanoscale mapping, AFM-IR chemical analysis, electrical measurements, and nanolithography applications.

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