<p><strong>The human body is the most sophisticated atomic engineer. This idea underpins a breakthrough technology developed by an international research team led by scientists from the Czech Advanced Technology and Research Institute (CATRIN) at Palacký University Olomouc and the Centre for Energy and Environmental Technologies (CEET) at VSB – Technical University of Ostrava. By drawing inspiration from the way enzymes function in the human body, the researchers have created a novel material that could fundamentally change the industrial production of hydrogen peroxide and other important chemicals. The new approach simplifies the production process, eliminates the need for toxic organic solvents and expensive precious metals, and requires only sunlight, oxygen and water to operate. The results </strong><a target="_blank" rel="noopener noreferrer" href="https://www.nature.com/articles/s41467-025-67189-3"><strong>were published by the prestigious journal </strong><i><strong>Nature Communications</strong></i></a><strong>, which ranked the study among the 50 most significant scientific discoveries of the year.</strong></p><p>Hydrogen peroxide is one of the most important industrial chemicals. It is widely used not only in the chemical industry but also in pharmaceuticals, medicine, the textile industry and water-treatment technologies. The global hydrogen peroxide market is estimated to exceed USD 5 billion annually. Conventional production involves a multistep process that relies on toxic organic solvents and costly palladium-based catalysts. In addition, both the starting chemicals and the resulting waste products can have negative impacts on human health and the environment.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/CATRIN_Cesti_vedci_vyvinuli_material_pro_vyrobu_chemikalii_z_vody_a_slunce_Inspirovali_se_lidskymi_enzymy_2_c4d5ecbafb.webp" alt="CATRIN: Czech scientists develop a material for producing chemicals from water and sunlight, inspired by human enzymes" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_CATRIN_Cesti_vedci_vyvinuli_material_pro_vyrobu_chemikalii_z_vody_a_slunce_Inspirovali_se_lidskymi_enzymy_2_c4d5ecbafb.webp 208w," sizes="100vw" width="1600" height="1200"></p><p><i>“Our aim was to develop a material that enables the efficient, environmentally friendly and affordable production of hydrogen peroxide. When designing this photocatalyst, we were inspired by the structure and behaviour of enzymes in the human body. The result is a technology that does not require toxic organic solvents or expensive precious metals and instead uses a low-cost material based on carbon, nitrogen and copper. It operates in water using only sunlight and oxygen from the air,”</i> said<strong> Radek Zbořil, leader of research teams at CATRIN and CEET</strong>.</p><p>In developing the new photocatalyst, the Czech scientists mimicked the function of cytochrome c oxidase—an enzyme that enables human cells to obtain energy by transferring electrons to oxygen. This process relies on copper atoms embedded in the enzyme’s structure, and it was precisely this mechanism that the researchers sought to reproduce.</p><p><i>“We very precisely replicated the chemical environment of metals within the enzyme’s structure and anchored copper atoms onto the surface of extremely small carbon nanoparticles with photocatalytic properties. When exposed to light, highly efficient electron transfer occurs between the carbon nanoparticles, the copper atoms and oxygen molecules. This process closely resembles an enzymatic reaction and enables high hydrogen peroxide production,”</i> explained the first author of the study, <strong>Lukáš Zdražil, who is affiliated with both CATRIN and CEET</strong>.</p><p>Producing hydrogen peroxide using sunlight and water has been a long-standing goal of research teams worldwide, as it eliminates the use of toxic organic solvents and avoids the formation of hazardous by-products. Until now, however, research in this area has largely remained at an academic level, mainly due to the use of noble metals and often complex photocatalyst designs. Laboratory studies have also resulted in relatively low hydrogen peroxide yields, which could not compete with existing industrial processes.</p><p><i>“<strong>The new photocatalyst achieves hydrogen peroxide production rates up to two orders of magnitude higher than all previously reported systems</strong>, bringing us much closer to industrial requirements. In addition, the material is completely non-toxic, easily recyclable and reusable,”</i> added Zdražil.</p><p>The Czech teams are now focusing on potential applications of this technology in decentralised production units. Such systems could enable efficient, local production of hydrogen peroxide, for example for use in agriculture, pharmaceutical manufacturing or environmental applications. The combination of solar energy and materials inspired by enzymatic systems may also lead to further promising advances.</p><p><i>“I believe that mimicking the structures and functions of iron- and copper-based enzymes could pave the way for other innovative technologies in the chemical industry and pharmaceuticals, such as the production of epoxides, alcohols or phenols,”</i> concluded Zbořil.</p>

 Czech scientists develop a material for producing chemicals from water and sunlight, inspired by human enzymes

<p><strong>In the week from February 23, the following webinars await you in the field of atomic and molecular spectroscopy and spectrometry</strong></p><blockquote><h4><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/webinars"><strong>👉 DETAILS AND REGISTRATION IN THE WEBINARS SECTION</strong></a></h4><p><strong>👉 Search and filter in the largest global database</strong> with over <strong>5 500 GC, LC, MS and spectroscopy webinars</strong>.</p></blockquote><h5><strong>1. Thermo Fisher Scientific: Lunch and Learn Tips and Tricks Series – Qtegra Part 1</strong></h5><ul><li>Tu, 24.2.2026 13:00 CET</li><li><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/webinar/5795">Registration</a></li></ul><p>Explore practical Qtegra ISDS workflows to boost trace elemental analysis quality and laboratory productivity, and learn how integrated tools help you get more from your instrumentation.</p><h5><strong>2. LECO: Total Sulfur and Carbon Determination in Cement and Raw Materials</strong></h5><ul><li>Tu, 24.2.2026 16:00 CET</li><li><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/webinar/5938">Registration</a></li></ul><p>Join Lloyd Allen for a practical webinar on total sulfur and carbon analysis in cement materials using the LECO SC832, including ASTM C150 compliance and furnace configuration insights.</p><h5><strong>3. Technology Networks: Real-Time In-Line Insight for Therapeutic Protein Production</strong></h5><ul><li>Tu, 24.2.2026 16:00 CET</li><li><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/webinar/5796">Registration</a></li></ul><p>Discover how real-time, in-line Raman monitoring improves control and consistency in therapeutic protein manufacturing by delivering actionable insights across downstream operations.</p><h5><strong>4. SelectScience: Cruise Through Genomics Quantification and QC with Lunatic</strong></h5><ul><li>Tu, 24.2.2026 17:00 CET</li><li><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/webinar/5837">Registration</a></li></ul><p>Learn how Lunatic enables fast, dye-free DNA and RNA quantification for NGS and biobanking, delivering accurate concentration and purity data from 96 samples in under 10 minutes.</p><h5><strong>5. Bruker: Accelerating Soil Health Assessment – High-Throughput Analysis with IR and EPR Spectroscopy</strong></h5><ul><li>Tu, 24.2.2026 17:00 CET</li><li><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/webinar/5758">Registration</a></li></ul><p>Discover how IR and EPR spectroscopy enable rapid, high-throughput soil analysis—from carbon, clay, and pH to free radicals and metals—supporting scalable soil health and contamination monitoring.</p><h5><strong>6. Agilent Technologies: Microplastics in Wastewater – A Population Based Approach to Identifying Potential Sources</strong></h5><ul><li>Tu, 24.2.2026 21:30 CET</li><li><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/webinar/2531">Registration</a></li></ul><p>Using LDIR within a closed wastewater treatment system, this webinar explores quantification of microplastics at different stages to identify potential contamination sources.</p><h5><strong>7. Mettler-Toledo: Dynamic Mechanical Analysis (DMA)</strong></h5><ul><li>Th, 26.2.2026 16:00 CET</li><li><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/webinar/5734">Registration</a></li></ul><p>Join this webinar to understand DMA principles, viscoelastic behavior, and practical applications for material testing across industries.</p><h5><strong>8. Bruker: Enhanced Data Capture for 3D Optical Profilers</strong></h5><ul><li>Th, 26.2.2026 17:00 CET</li><li><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/webinar/5911">Registration</a></li></ul><p>Discover Enhanced Data Capture metrology and learn how it delivers richer, more reliable measurements on steep, rough, and complex surfaces, including live demonstrations and real-world applications.</p>

Webinars LabRulezICPMS Week 09/2026

<p><strong>Matrix effects significantly limit accurate nanoparticle sizing in single-particle ICP-MS, often causing signal attenuation and size underestimation. This study systematically evaluates matrix-induced biases and reports up to 10 nm underestimation of Ag nanoparticle sizes due to 30–50% signal loss.</strong></p><p>To overcome these challenges, a novel online internal standard calibration strategy was developed using multielement detection and nonanalyte elements (Pd, Au) as internal standards. Simultaneous measurement of analyte and standards enabled correction of signal response and nebulization efficiency within a single run. The optimized approach provided accurate particle size determination in simulated and real matrices, extending SP-ICP-MS applicability to complex environmental and biological samples.</p><blockquote><h4><strong>The original article</strong></h4><h4><a target="_blank" rel="noopener noreferrer" href="https://pubs.acs.org/doi/10.1021/acs.analchem.5c06975"><strong>A Simple Online Internal Standard Calibration Strategy for Single-Particle Inductively Coupled Plasma Mass Spectrometry Based on Multielement Analysis</strong></a></h4><p>Xiangwei Tian, Ying Wang, Peijie Yang, Dingyi Wang, Yanwei Liu, Yingying Guo, Yuning Hu*, Xiaoyan Zhang*, Ligang Hu, Yongguang Yin*, Yong Cai, and Guibin Jiang</p><p>Anal. Chem. 2025, 97, 51, 28139–28147</p><p><a target="_blank" rel="noopener noreferrer" href="https://doi.org/10.1021/acs.analchem.5c06975">https://doi.org/10.1021/acs.analchem.5c06975</a></p><h6>licensed under <a target="_blank" rel="noopener noreferrer" href="https://creativecommons.org/licenses/by/4.0/"><strong>CC-BY 4.0</strong></a></h6></blockquote><p><strong>Selected sections from the article follow. Formats and hyperlinks were adapted from the original.</strong></p><div><p>Nanoparticles (NPs) are ubiquitous in environmental and biological systems. <a href="javascript:void(0);">(1)</a> In the environment, billions of tons of natural NPs are formed annually through biogeochemical processes. <a href="javascript:void(0);">(1)</a> Engineered NPs are widely utilized in industrial, medical, and consumer products and inevitably released into the environment. <a href="javascript:void(0);">(2)</a> In biological systems, NPs can be endogenously formed <a href="javascript:void(0);">(3)</a> or acquired from environmental exposure. <a href="javascript:void(0);">(4)</a> Functional NPs can also be intentionally delivered into biological systems as probes or drugs. <a href="javascript:void(0);">(5−7)</a> Variations in physicochemical properties of NPs, such as size and elemental composition, can influence their distribution patterns and effects within environmental and biological systems. <a href="javascript:void(0);">(8,9)</a> Therefore, it is of great significance to resolve particle heterogeneity at the single-particle level. Single particle inductively coupled plasma mass spectrometry (SP-ICP-MS), with its high-throughput and sensitive capabilities for elemental and isotopic analysis, plays a key role in single-particle analysis. <a href="javascript:void(0);">(10,11)</a></p><p>Environmental particles always exist in complex or unknown matrices, such as ice cores, <a href="javascript:void(0);">(12)</a> wastewater, <a href="javascript:void(0);">(13)</a> and seawater. <a href="javascript:void(0);">(14)</a> Biological matrices are even more intricate, typically containing high concentrations of inorganic salts and organic matter. Matrix effects pose significant challenges for SP-ICP-MS analysis of environmental and biological samples. <a href="javascript:void(0);">(15)</a> Matrix effects on ICP-MS are generally categorized into spectral and nonspectral interferences. <a href="javascript:void(0);">(15)</a> Spectral interferences arise from isobaric overlaps or polyatomic ions (e.g., ArCl<sup>+</sup> from Cl<sup>–</sup> interfering with <sup>75</sup>As detection), which can often be eliminated using collision/reaction cell technique. <a href="javascript:void(0);">(16)</a> Nonspectral interferences refer to matrix-induced changes in signal intensity. <a href="javascript:void(0);">(17)</a> For instance, NaCl can suppress signal intensity, whereas low concentrations of methanol may lead to signal enhancement. Changes in signal intensity further contribute to errors in mass/size measurement. It was reported that a 4.5 g L<sup>–1</sup> NaCl matrix caused underestimation of As(0) NP and Ag NP sizes by 28% and 41%, respectively, while a 2% methanol matrix resulted in overestimations of approximately 6% and 20%. <a href="javascript:void(0);">(17)</a> Common strategies to address nonspectral interferences include sample dilution and matrix matching. <a href="javascript:void(0);">(15)</a> However, dilution pretreatments would greatly reduce the analytical throughput, and changes in matrix concentration may affect the properties or state of the analyte. In real-world samples, the matrices are always complex, making it difficult to prepare solutions with exactly the same composition for matrix matching. Isotope dilution analysis (IDA), which involves enriched isotopes of the analyte element for signal response correction, is another established approach. <a href="javascript:void(0);">(18−20)</a> Nevertheless, due to strict requirements on matrix types, isotope properties, and analyte concentrations, IDA has limited applicability to real-world sample measurements. Furthermore, among the previously reported methods, the potential influence of the matrix on particle nebulization efficiency has not been fully considered, <a href="javascript:void(0);">(18,21,22)</a> leaving quantitative uncertainties. <a href="javascript:void(0);">(17)</a> The online droplet calibration method based on the microdroplet generator and ICP-time-of-flight (TOF)-MS considers matrix effects on both signal response and nebulization efficiency; <a href="javascript:void(0);">(15,23)</a> however, the technical barriers and high cost largely limit its broader adoption. Till now, due to the lack of practical calibration methods, the characterization of NPs in real matrices typically involves laborious extraction procedures. <a href="javascript:void(0);">(24,25)</a> A need exists to develop a simple and reliable calibration strategy suitable for the measurement in the original matrix.</p><p>In this study, we first systematically investigated the specific matrix effects on SP-ICP-MS and the underlying mechanisms based on the fundamentals of ICP-MS. The influence of time resolution on multielement detection was explored from multiple analytical perspectives. To address limitations of previous methods, we proposed a simple and reliable online internal standard calibration method, which largely eliminates matrix effects on size/mass determination by SP-ICP-MS. By utilizing the multielement detection mode, the signals of the analyte element(s) and internal standard elements can be monitored within the same analytical run, allowing for simultaneous correction of the response factor, nebulization efficiency, and time-dependent signal fluctuations. Notably, the novel calibration strategy involving the use a nonanalyte element as the internal standard for signal response calibration was developed and validated. The proposed method demonstrated high feasibility and reliability when applied to simulated real-world samples. It is also applicable to single-particle analysis using other types of ICP-MS (e.g., ICP-TOF-MS) and shows promise for application in single-cell ICP-MS analysis.</p><h4><strong>Experimental Section</strong></h4><h5><strong>SP-ICP-MS Analysis</strong></h5><p><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/library?mainauthorItems=10&amp;search=7900+ICP-MS"><strong>Agilent 7900 ICP-MS</strong></a> (Agilent Technologies; Santa Clara, CA, USA) equipped with a quadrupole mass analyzer was used for SP-ICP-MS analysis. Instrument parameters are given in <a target="_blank" rel="noopener noreferrer" href="https://pubs.acs.org/doi/suppl/10.1021/acs.analchem.5c06975/suppl_file/ac5c06975_si_001.pdf">Table S2</a>. The sample introduction system was composed of syringe pumps (Leifu Fluid; Baoding, China), a Mira Mist nebulizer (Burgener; Mississauga, Ontario, Canada), and a quartz dual-channel spray chamber (Agilent Technologies; Santa Clara, CA, USA) (<a target="_blank" rel="noopener noreferrer" href="https://pubs.acs.org/doi/10.1021/acs.analchem.5c06975#fig1">Figure 1</a>). The total sample flow rates were 300 μL min<sup>–1</sup> for all the experiments. Additionally, a more accessible introduction approach using the instrument’s integrated peristaltic pump was also tested (<a target="_blank" rel="noopener noreferrer" href="https://pubs.acs.org/doi/suppl/10.1021/acs.analchem.5c06975/suppl_file/ac5c06975_si_001.pdf">Figure S2</a>). Matrix effects on SP-ICP-MS analysis was investigated under the conventional single-element mode. The dwell time was 5 ms, with no stabilization time. The final inlet concentrations of Ag NPs and Au NPs were 50 ng L<sup>–1</sup> (∼4.2 × 10<sup>4</sup> particles mL<sup>–1</sup>) and 25 ng L<sup>–1</sup> (∼4 × 10<sup>4</sup> particles mL<sup>–1</sup>), respectively.</p><h4><strong>Results and Discussion</strong></h4><h5><strong>Matrix Effects on SP-ICP-MS and the Underlying Mechanisms</strong></h5><p>In the UPW matrix, the particle sizes determined by SP-ICP-MS (<a target="_blank" rel="noopener noreferrer" href="https://pubs.acs.org/doi/10.1021/acs.analchem.5c06975#fig2">Figure 2</a>A) were consistent with those measured by TEM (<a target="_blank" rel="noopener noreferrer" href="https://pubs.acs.org/doi/suppl/10.1021/acs.analchem.5c06975/suppl_file/ac5c06975_si_001.pdf">Figure S1A</a>). The most direct impact of matrix effects was observed as changes in the analyte signal intensity. Both the typical environmental and biological matrices we selected resulted in signal attenuation for the target elements. More pronounced signal attenuation was observed in the salt matrices with increasing concentration. Compared to measurements in UPW, the signal intensity of Ag NPs decreased by approximately 32% and 46% in DSW and PBS, respectively. Correspondingly, without matrix-matching correction, the particle sizes of Ag NPs were underestimated by approximately 12% and 19% in DSW and PBS, respectively (<a target="_blank" rel="noopener noreferrer" href="https://pubs.acs.org/doi/10.1021/acs.analchem.5c06975#fig2">Figure 2</a>A).</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Anal_Chem_2025_97_51_28139_28147_Figure_2_A_Particle_size_distribution_of_Ag_N_Ps_in_different_matrices_without_matrix_matching_f97e96e68c.jpeg" alt="Anal. Chem. 2025, 97, 51, 28139–28147: Figure 2. (A) Particle size distribution of Ag NPs in different matrices without matrix matching. The gray line and band denote the mean and standard deviation of the particle size determined by TEM. (B) Nebulization efficiency of Au NPs in different matrices. The letters on columns indicate the statistical difference obtained from one-way ANOVA test (p &lt; 0.05). (C) Signal intensity of standard Au NPs and AuCl4– solution in different matrices." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Anal_Chem_2025_97_51_28139_28147_Figure_2_A_Particle_size_distribution_of_Ag_N_Ps_in_different_matrices_without_matrix_matching_f97e96e68c.jpeg 245w," sizes="100vw" width="2100" height="537"></p><p>Matrix-induced attenuation/enhancement of signal intensity fundamentally arise from changes in the transport efficiency of the analyte. Transport efficiency is defined as a combination of several components (<a target="_blank" rel="noopener noreferrer" href="https://pubs.acs.org/doi/10.1021/acs.analchem.5c06975#fig1">Figure 1</a>): (i) the aerosol introduction efficiency (or nebulization efficiency) from the sample introduction system (typically comprising a nebulizer and spray chamber) to the ICP torch, as calculated using <a target="_blank" rel="noopener noreferrer" href="https://pubs.acs.org/doi/10.1021/acs.analchem.5c06975#eq1">Equation 1</a>) or <a target="_blank" rel="noopener noreferrer" href="https://pubs.acs.org/doi/10.1021/acs.analchem.5c06975#eq2">2</a>); (ii) the ionization efficiency of the analyte within the ICP torch; and (iii) the subsequent extraction and transport efficiency of ions from the sampling cone to the detector.</p><h5><strong>Validation of Online Internal Standard Calibration</strong></h5><p><a target="_blank" rel="noopener noreferrer" href="https://pubs.acs.org/doi/10.1021/acs.analchem.5c06975#fig4">Figure 4</a>A displays the Ag NP size distribution determined when the three inlet streams (Ag NP suspension, Au NP suspension, and Pd solution) were mixed at equal flow rates (3 × 100 μL min<sup>–1</sup>). For all the matrices, the measured particle sizes showed good agreement with the actual sizes determined by TEM. Note that since both the Au NP suspension and Pd solution were prepared using UPW, the matrix containing analyte Ag NPs would be diluted upon online mixing. For real-world samples, excessive dilution could potentially change sample properties and reduce measurement throughput. To prevent excessive dilution, the calibration results were further assessed under conditions of reduced internal standard flow rates (Ag NP flow rate: 260 μL min<sup>–1</sup>; internal standard flow rates: both 20 μL min<sup>–1</sup>) (<a target="_blank" rel="noopener noreferrer" href="https://pubs.acs.org/doi/10.1021/acs.analchem.5c06975#fig4">Figure 4</a>B). Furthermore, an offline spiking approach was also tested by adding both the internal standards directly into the sample suspension (<a target="_blank" rel="noopener noreferrer" href="https://pubs.acs.org/doi/suppl/10.1021/acs.analchem.5c06975/suppl_file/ac5c06975_si_001.pdf">Figure S7A</a>). The measured sizes also agreed well with the true values. For easier access and use, online mixing using a peristaltic pump was also tested and demonstrated to accurately determine the particle sizes (<a target="_blank" rel="noopener noreferrer" href="https://pubs.acs.org/doi/suppl/10.1021/acs.analchem.5c06975/suppl_file/ac5c06975_si_001.pdf">Figure S7B</a>). The results demonstrate that neither the introduction approach and the mixing ratio affected the calibration performance, suggesting the high reliability and flexibility of the internal standard calibration method.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Anal_Chem_2025_97_51_28139_28147_Figure_4_A_B_Particle_size_distribution_of_Ag_N_Ps_in_different_matrices_measured_by_the_internal_standard_calibration_method_4ca8d3833d.jpeg" alt="Anal. Chem. 2025, 97, 51, 28139–28147: Figure 4. (A, B) Particle size distribution of Ag NPs in different matrices measured by the internal standard calibration method. (A) Flow rates of the analyte and internal standards were all 100 μL min–1. (B) Flow rates of the analyte and internal standards were 260 and 20 μL min–1, respectively. (C, D) Particle size distribution of Ag NPs in natural seawater (C) and human urine (D) matrices measured by external standard calibration or online internal standard calibration method. the flow rates of the analyte and internal standards were 260 and 20 μL min–1, respectively. The gray lines and bands denote the mean and standard deviation of the particle size determined by TEM." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Anal_Chem_2025_97_51_28139_28147_Figure_4_A_B_Particle_size_distribution_of_Ag_N_Ps_in_different_matrices_measured_by_the_internal_standard_calibration_method_4ca8d3833d.jpeg 189w," sizes="100vw" width="1433" height="1184"></p><p>Further, we evaluated the performance of the proposed method in handling real biological (human urine) and environmental (natural seawater) matrices (<a target="_blank" rel="noopener noreferrer" href="https://pubs.acs.org/doi/10.1021/acs.analchem.5c06975#fig4">Figure 4</a>C and D). In addition to high salt concentrations, both matrices contain abundant organic matter, which pose challenges to accurate SP-ICP-MS analysis. Without matrix matching, the sizes of Ag NPs in both matrices were significantly underestimated. Particularly in seawater, the size was underestimated by nearly 20 nm. Using the online internal standard calibration, the median sizes of Ag NPs in diluted seawater and urine matrices were 58.9 and 58.5 nm, respectively, in close agreement with those determined by TEM. Notably, the sizes of Ag NPs in undiluted real matrices can also be accurately determined, facilitating the measurement of environmental particles in the original matrix.</p><h4><strong>Conclusions</strong></h4><p>In this study, we addressed the significant challenge of matrix effects in SP-ICP-MS for accurate mass/size determination in complex environmental and biological samples. We elucidated the specific matrix effects on nebulization efficiency, ionization efficiency, and ion transport. It was demonstrated that Ag NP signal intensity decreased by approximately 32% and 46% in DSW and PBS, respectively, leading to underestimated particle sizes (12% and 19%, respectively). To address these issues, we developed and validated an online internal standard calibration strategy employing multielement detection with nonanalyte elements as internal standards. By simultaneously monitoring analyte (Ag) and internal standard elements (Au for nebulization efficiency, Pd for response factor) within a single analytical run via the peak-hopping mode, we achieved real-time correction for matrix-induced variations. Optimized time-resolution conditions, particularly a 5 ms dwell time, ensured a high probability of complete event acquisition (81.8%) while minimizing particle overlapping. The measured sizes of Ag NPs in simulated (DSW and PBS) and real (natural seawater and human urine) matrices that showed good agreement with true values. The proposed method demonstrated high reliability and flexibility, regardless of the internal standard mixing ratio (e.g., 100:100:100 or 260:20:20 μL min<sup>–1</sup>), introduction approach, and sample dilution levels. In contrast to enriched isotope internal standards, which proved ineffective in anion-rich matrices due to chemical reactions, the presented nonanalyte internal standards offer enhanced adaptability across various matrices.</p><p>This reliable and flexible method significantly extends the applicability of SP-ICP-MS to direct analysis of complex samples without laborious pretreatments. The potential for the measurement in the original matrix is particularly meaningful for single-cell analysis, allowing direct analysis of living cells in biological matrices. Note that the theory and method validated with Ag NPs are also applicable to the quantification of other elements in particles or cells. As a simplified alternative to the established online microdroplet calibration, <a href="javascript:void(0);">(23)</a> the proposed strategy shows great promise in the integration of advanced ICP-TOF-MS platforms for simultaneous calibration of multiple analyte elements.</p></div>

A Simple Online Internal Standard Calibration Strategy for Single-Particle Inductively Coupled Plasma Mass Spectrometry Based on Multielement Analysis

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<div><p><strong>This webinar introduces scattering scanning nearfield optical microscopy (s-SNOM), which provides&nbsp;information about the complex optical properties of the nanoscale region of a sample under a metallized tip that nanofocuses optical radiation. Recent developments in novel methods, advanced light sources, and refined instrumentation have made s-SNOM more valuable and accessible.</strong></p><p>Capabilities for s-SNOM are available on Bruker’s <a target="_blank" rel="noopener noreferrer" href="https://www.bruker.com/en/products-and-solutions/infrared-and-raman/nanoscale-infrared-spectrometers/anasys-nanoir3-s.html">nanoIR3-s</a> and <a target="_blank" rel="noopener noreferrer" href="https://www.bruker.com/en/products-and-solutions/infrared-and-raman/nanoscale-infrared-spectrometers/anasys-nanoir3-s-broadband.html">nanoIR3-s Broadband</a> platforms, and the technique itself was developed in collaboration with the webinar’s guest speaker, Professor Markus Raschke, Dept. of Physics/JILA, University of Colorado.</p><p>After a thorough and illustrative introduction to the method, Prof. Raschke presents his research efforts towards using s-SNOM, this new dimension in optical nanoprobe imaging, to access the functional properties of materials and systems including electronic materials, energy materials, nano-biomaterials, quantum systems, and more.</p><p>Following Prof. Raschke’s comprehensive presentation, he answers questions from the audience covering topics from the maximum sensitivity level of s-SNOM to the use of complementary AFM techniques with s-SNOM.&nbsp;</p></div>

Bruker: Recent Advancements in Infrared Nano-imaging with Nano-FTIR Spectroscopy

Recent Advancements in Infrared Nano-imaging with Nano-FTIR Spectroscopy

Learn how s-SNOM advances understanding of the functional properties of materials

Advances in Infrared Nano-imaging with Nano-FTIR

<div><div><div><p><strong>Due to the systematic shrinking of the size of devices in the semiconductor industry, characterizing nanoscale surface contaminations in interconnects and circuitries has become a pivotal issue in test and failure analysis. Continuous development in process technology/engineering has led to the fabrication of semiconductor devices with sub-µm feature resolution, which in turn demands high-resolution analytical tools for proper characterization.&nbsp;</strong></p><p>Nanoscale AFM-IR spectroscopy is a non-destructive chemical analysis method that takes advantage of the nanoscale capabilities of AFM and outputs easy-to-understand, FTIR-like spectra. As described by the presenters, the advantages of nanoscale AFM-IR can be leveraged in the semiconductor industry in many ways, like for chemical characterization of organic contaminants, nano-patterned metal/low-k dielectrics, and directed self-assembly of block copolymers.</p></div></div></div><div><div><blockquote><ul><li><a data-g-name="CallToAction" data-protectable="" data-tracking="{&quot;classification&quot;:&quot;default&quot;,&quot;webinarDate&quot;:1587340800000,&quot;onWebinar&quot;:true,&quot;external&quot;:false}" target="_self"><a target="_blank" rel="noopener noreferrer" href="https://www.bruker.com/en/news-and-events/webinars/2020/two-complementary-nanoscale-ir-techniques-photothermal-afm-ir-and-s-snom.html"><strong>watch part 1: Two Complementary Nanoscale IR Techniques: Photothermal AFM-IR and s-SNOM&nbsp;</strong></a></a></li><li><a data-g-name="CallToAction" data-protectable="" data-tracking="{&quot;classification&quot;:&quot;default&quot;,&quot;webinarDate&quot;:1587340800000,&quot;onWebinar&quot;:true,&quot;external&quot;:false}" target="_self"><a target="_blank" rel="noopener noreferrer" href="https://www.bruker.com/en/news-and-events/webinars/2020/online-demo-of-the-nanoir3-system-photothermal-afm-ir.html"><strong>watch part 2: Online Demo of the nanoIR3 System - Photothermal AFM-IR&nbsp;</strong></a></a></li><li><a data-g-name="CallToAction" data-protectable="" data-tracking="{&quot;classification&quot;:&quot;default&quot;,&quot;webinarDate&quot;:1587340800000,&quot;onWebinar&quot;:true,&quot;external&quot;:false}" target="_self"><a target="_blank" rel="noopener noreferrer" href="https://www.bruker.com/en/news-and-events/webinars/2020/chemical-characterization-of-heterogenous-polymeric-materials-on-the-nanoscale-using-photothermal-afm-ir.html"><strong>watch part 3: Chemical Characterization of Heterogenous Polymeric Materials on the Nanoscale Using Photothermal AFM-IR&nbsp;</strong></a></a></li><li><a data-g-name="CallToAction" data-protectable="" data-tracking="{&quot;classification&quot;:&quot;default&quot;,&quot;webinarDate&quot;:1587340800000,&quot;onWebinar&quot;:true,&quot;external&quot;:false}" target="_self"><a target="_blank" rel="noopener noreferrer" href="https://www.bruker.com/en/news-and-events/webinars/2020/2d-material-characterization-using-photothermal-afm-ir-and-s-snom.html"><strong>watch part 5: 2D Material Characterization Using Photothermal AFM-IR and s-SNOM&nbsp;</strong></a></a></li></ul></blockquote></div></div>

Bruker: Nanoscale AFM-IR Spectroscopy and Imaging for Failure Analysis of Electronic Devices

Nanoscale AFM-IR Spectroscopy and Imaging for Failure Analysis of Electronic Devices

Characterizing nanometer-scale features in semiconductor devices using nanoIR spectroscopy

Nanoscale AFM-IR for Failure Analysis of Electronics

<div><p><span style="letter-spacing:0.0px;"><strong>This webinar will show you the analysis of two standard samples in failure analysis and troubleshooting with the LUMOS II.&nbsp;</strong></span></p><p>Our application specialist Eric Klein skips lengthy PowerPoint presentations and welcomes you directly to our demo lab for a hands-on instrument session. After 20 minutes of analyzing typical samples, Eric will answer your questions about using µ-FT-IR in your daily QC and failure analysis for at least 30 minutes.</p><p><strong>About the samples:</strong></p><ul><li>The first sample is a typical customer complaint which was returned due to an unknown contaminant on the products surface.</li><li>The second sample is is a product contamination found during quality control. It is analyzed to understand the contamination route and prevent recurrence.</li></ul><p><strong>Content of webinar:</strong></p><ul><li>Measurement two typical µ-FT-IR samples</li><li>Detection and identification of unknown contaminants</li><li>Q&amp;A session on failure analysis by FT-IR</li></ul><p><strong>What you'll learn:</strong></p><ul><li>How to FT-IR microscopy is used to analyze contaminations.</li><li>How to apply the LUMOS II FT-IR microscope</li><li>How to evaluate using OPUS software</li></ul><blockquote><p><strong>Presenter: </strong>Eric Klein&nbsp;</p><p>Eric Klein has been with Bruker for 10 years and started out as an application scientist. During this time, he has acquired a great deal of expertise in infrared microscopy and, as a product manager, played a leading role in the development of LUMOS II. The session will be moderated.</p></blockquote></div>

Bruker: About Failure Analysis, Customer Complaints and Troubleshooting

About Failure Analysis, Customer Complaints and Troubleshooting

This webinar will show you the analysis of two standard samples in failure analysis and troubleshooting with the LUMOS II. 

Failure Analysis, Complaints & Troubleshooting Insights

<div><p><strong>Photothermal AFM-IR can provide nanoscale chemical information with highly resolved IR spectra, that directly correlate to FTIR transmission spectroscopy. This webinar covers numerous AFM-IR applications in the field of life sciences, illustrating broad applicability for samples from tissue to single protein fibrils. The speaker also discusses issues, challenges, and potentials of correlative measurements.</strong></p><p><strong>Some of the samples and applications presented include:</strong></p><ul><li>Lipids bodies stored in microorganisms</li><li>Abnormal accumulations in kidney biopsy</li><li>Penetration of nanocarriers in tissue or model cell lines</li><li>Protein nano-assemblies structures</li></ul><p><strong>The speaker discusses the new experimental approaches developed to solve problems encountered during these studies, and the efforts to overcome technical constraints imposed by the system itself, such as:</strong></p><ul><li>Configuration of illumination</li><li>Sensitivity</li><li>Soft-sample damage</li></ul></div>

Bruker: Photothermal AFM-IR Spectroscopy and Imaging for Life Science

Photothermal AFM-IR Spectroscopy and Imaging for Life Science

This webinar explores AFM-IR applications in life sciences, showing its wide use from tissue samples to single protein fibrils.

Photothermal AFM-IR for Life Science Spectroscopy & Imaging

<div><p><strong>During this webinar, the speaker considers how photothermal AFM-IR can benefit the polymer characterization applications of:</strong></p><ul><li>Multilayer films</li><li>Polymer blends/block copolymers</li><li>Organic photovoltaics</li></ul><div><div><div><p>This webinar covers numerous academia and industry applications in the field of polymer characterization. To illustrate the broad applicability, select examples are discussed in detail, ranging from phase separation in polymer blends/block copolymers and reverse engineering in multilayer films to fibers and thin film characterization. This webinar shows how photothermal AFM-IR provides nanoscale chemical information with highly resolved IR spectra that directly correlate to FT-IR transmission spectroscopy.</p></div></div></div><div><div><blockquote><ul><li><a data-g-name="CallToAction" data-protectable="" data-tracking="{&quot;classification&quot;:&quot;default&quot;,&quot;webinarDate&quot;:1586649600000,&quot;onWebinar&quot;:true,&quot;external&quot;:false}" target="_self"><a target="_blank" rel="noopener noreferrer" href="https://www.bruker.com/en/news-and-events/webinars/2020/two-complementary-nanoscale-ir-techniques-photothermal-afm-ir-and-s-snom.html"><strong>watch part 1: Two Complementary Nanoscale IR Techniques: Photothermal AFM-IR and s-SNOM&nbsp;</strong></a></a></li><li><a data-g-name="CallToAction" data-protectable="" data-tracking="{&quot;classification&quot;:&quot;default&quot;,&quot;webinarDate&quot;:1586649600000,&quot;onWebinar&quot;:true,&quot;external&quot;:false}" target="_self"><a target="_blank" rel="noopener noreferrer" href="https://www.bruker.com/en/news-and-events/webinars/2020/online-demo-of-the-nanoir3-system-photothermal-afm-ir.html"><strong>watch part 2: Online Demo of the nanoIR3 System - Photothermal AFM-IR&nbsp;</strong></a></a></li><li><a data-g-name="CallToAction" data-protectable="" data-tracking="{&quot;classification&quot;:&quot;default&quot;,&quot;webinarDate&quot;:1586649600000,&quot;onWebinar&quot;:true,&quot;external&quot;:false}" target="_self"><a target="_blank" rel="noopener noreferrer" href="https://www.bruker.com/en/news-and-events/webinars/2020/nanoscale-afm-ir-spectroscopy-and-imaging-for-failure-analysis-of-electronic-devices.html"><strong>watch part 4: Nanoscale AFM-IR Spectroscopy and Imaging for Failure Analysis of Electronic Devices&nbsp;</strong></a></a></li><li><a data-g-name="CallToAction" data-protectable="" data-tracking="{&quot;classification&quot;:&quot;default&quot;,&quot;webinarDate&quot;:1586649600000,&quot;onWebinar&quot;:true,&quot;external&quot;:false}" target="_self"><a target="_blank" rel="noopener noreferrer" href="https://www.bruker.com/en/news-and-events/webinars/2020/2d-material-characterization-using-photothermal-afm-ir-and-s-snom.html"><strong>watch part 5: 2D Material Characterization Using Photothermal AFM-IR and s-SNOM&nbsp;</strong></a></a></li></ul></blockquote></div></div></div>

Bruker: Chemical Characterization of Heterogenous Polymeric Materials on the Nanoscale Using Photothermal AFM-IR

Chemical Characterization of Heterogenous Polymeric Materials on the Nanoscale Using Photothermal AFM-IR

This webinar covers numerous academia and industry applications in the field of polymer characterization. 

Nanoscale Chemical Analysis of Polymers with AFM-IR

<div><div><div><div><p><strong>This&nbsp;webinar introduces two main techniques for nanoscale IR measurements: Photothermal AFM-IR (PTIR/AFM-IR) and IR-based Scattering Scanning Nearfield Optical Microscopy (IR s-SNOM).</strong></p><div><div><div><p><strong>The presenter, Dr. Phillips, differentiates AFM-IR and s-SNOM by comparing them to more familiar techniques:&nbsp;</strong>&nbsp;</p><ul><li>AFM-IR is like a nanoscale FTIR</li><li>s-SNOM is like a nanoscale ellipsometry</li></ul><p>Dr. Phillips delves into the fundamentals behind AFM-IR and s-SNOM. Both complementary modes are combined in Bruker’s <a target="_blank" rel="noopener noreferrer" href="https://www.bruker.com/en/products-and-solutions/infrared-and-raman/nanoscale-infrared-spectrometers/anasys-nanoir3-s.html">nanoIR3-s</a> platform.</p><p><strong>Also included in this in-depth introductory webinar are:</strong></p><ul><li>Exemplary case studies for both AFM-IR and s-SNOM</li><li>System configuration descriptions, accompanied by real-machine images</li><li>An extensive Q&amp;A session, where the presenter answers audience questions</li></ul><p><strong>In the Q&amp;A session, viewers can expect to hear the answers to:</strong></p><ul><li>Can AFM-IR be performed in fluid?</li><li>What are typical sample requirements for nanoscale IR techniques?</li><li>What is the probing depth of the laser and that of each technique?</li><li>Can nanoscale IR techniques be performed using a synchrotron source?&nbsp;</li></ul></div></div></div><div><div><blockquote><ul><li><a data-g-name="CallToAction" data-protectable="" data-tracking="{&quot;classification&quot;:&quot;default&quot;,&quot;webinarDate&quot;:1586044800000,&quot;onWebinar&quot;:true,&quot;external&quot;:false}" target="_self"><a target="_blank" rel="noopener noreferrer" href="https://www.bruker.com/en/news-and-events/webinars/2020/online-demo-of-the-nanoir3-system-photothermal-afm-ir.html"><strong>watch part 2: Online Demo of the nanoIR3 System - Photothermal AFM-IR&nbsp;</strong></a></a></li><li><a data-g-name="CallToAction" data-protectable="" data-tracking="{&quot;classification&quot;:&quot;default&quot;,&quot;webinarDate&quot;:1586044800000,&quot;onWebinar&quot;:true,&quot;external&quot;:false}" target="_self"><a target="_blank" rel="noopener noreferrer" href="https://www.bruker.com/en/news-and-events/webinars/2020/chemical-characterization-of-heterogenous-polymeric-materials-on-the-nanoscale-using-photothermal-afm-ir.html"><strong>watch part 3: Chemical Characterization of Heterogenous Polymeric Materials on the Nanoscale Using Photothermal AFM-IR&nbsp;</strong></a></a></li><li><a data-g-name="CallToAction" data-protectable="" data-tracking="{&quot;classification&quot;:&quot;default&quot;,&quot;webinarDate&quot;:1586044800000,&quot;onWebinar&quot;:true,&quot;external&quot;:false}" target="_self"><a target="_blank" rel="noopener noreferrer" href="https://www.bruker.com/en/news-and-events/webinars/2020/nanoscale-afm-ir-spectroscopy-and-imaging-for-failure-analysis-of-electronic-devices.html"><strong>watch part 4: Nanoscale AFM-IR Spectroscopy and Imaging for Failure Analysis of Electronic Devices&nbsp;</strong></a></a></li><li><a data-g-name="CallToAction" data-protectable="" data-tracking="{&quot;classification&quot;:&quot;default&quot;,&quot;webinarDate&quot;:1586044800000,&quot;onWebinar&quot;:true,&quot;external&quot;:false}" target="_self"><a target="_blank" rel="noopener noreferrer" href="https://www.bruker.com/en/news-and-events/webinars/2020/2d-material-characterization-using-photothermal-afm-ir-and-s-snom.html"><strong>watch part 5: 2D Material Characterization Using Photothermal AFM-IR and s-SNOM&nbsp;</strong></a></a></li></ul></blockquote><blockquote><p><strong>Presenter: </strong>Cassandra Phillips, Ph.D. Bruker expert&nbsp;</p></blockquote></div></div></div></div></div></div>

Bruker: Two Complementary Nanoscale IR Techniques: Photothermal AFM-IR and s-SNOM

Two Complementary Nanoscale IR Techniques: Photothermal AFM-IR and s-SNOM

This webinar introduces two main techniques for nanoscale IR measurements: PTIR/AFM-IR and IR s-SNOM

AFM-IR & s-SNOM: Two Complementary Nanoscale IR Methods

<p><strong>INVENIO is Bruker’s next generation and fully upgradeable FT-IR platform from sophisticated routine to advanced research applications.</strong>&nbsp;</p><p>The new INVENIO X with patented INTEGRAL<sup>TM</sup>&nbsp;interferometer represents the multispectral range R&amp;D spectrometer with the world’s highest degree of automation. Combining the pioneering 5x MultiTect technology and the INTEGRAL<sup>TM</sup>&nbsp;interferometer with integrated automatic 3x beam splitter changer provides unmatched flexibility and performance for advanced R&amp;D applications.</p><p>A long list of further smart features, such as the additional Transit<sup>TM</sup>&nbsp;sample compartment, the flexible high performance optics path with up to 7 internal detectors, electronically coded windows, optional embedded touch panel with dedicated software and many more.&nbsp;</p><p>With this webinar we will provide you an overview of the INVENIO R&amp;D capabilities including many interesting application examples.</p>

Bruker: Fully automated multispectral range FT-IR R&D spectrometer

Fully automated multispectral range FT-IR R&D spectrometer

With this webinar we will provide you an overview of the INVENIO R&D capabilities including many interesting application examples.

<div><div><div><div><div><div><div><div><div><p><strong>The need for high-resolution techniques is regarded as being urgent for Higher Order Structure (HOS:secondary, tertiary and quaternary structure) comparability and similarity assessment. Recently, new developments in acquisition and data analysis have emerged to establish NMR as a powerful tool for HOS characterization of intact molecules at natural abundance.</strong></p><p>The application of 1D and 2D NMR of the intact molecule at isotope natural abundance to routine analyses (characterization for comparability/similarity) will be presented. Fast 1D fingerprinting methods will give a quick answer if a batch is comparable to another or to the reference material. To identify changes at the amino acid level, 2D NMR methods are required. Results obtained from three real case studies will be discussed: a nanobody (40 kDa molecule in simple buffer) and two recombinant mAbs in a complex buffer (142 kDa and 177 kDa, respectively).</p><p>There is no single solution to the problem of evaluation of HOS. Techniques typically used for HOS characterization (CD, HDX-MS, fluorescence, FT-IR, thermal analysis by NanoDSC) measure different aspects of structure, either directly and indirectly. NMR offers superior resolution, sensitivity, and characterization of multiple structural aspects with a single experiment.</p><p><strong>What You Will Learn</strong></p></div><div><div><div><div><div><div><ul><li>How NMR provides a solution to the need for Atomic Resolution in HOS characterization;</li><li>How NMR can be applied to intact molecules at natural abundance, with acquisition times reasonable for routine analysis;</li><li>How NMR is a high precision analytical technique and produces data that is the ideal input for robust statistical tools required for HOS evaluation;</li></ul><p><strong>Who Should Attend</strong></p><p>This webinar will be of interest to those involved in the development and manufacturing of biologics and biosimilars, especially in their analysis, testing and quality control - analytical R&amp;D, QC, QA scientist and leaders seeking to enhance and optimize their analytical capabilities with cutting-edge, information-rich technology. Also relevant for academics developing analytical methods for the study of therapeutic drugs and those working in close collaboration with the biopharmaceutical industry.</p><blockquote><p><strong>Presenter: </strong>Dr. Fabio Baroni (Associate Researcher - Protein Chemistry Department – Physico-Chemical characterization Lab - Merck Serono S.p.A. - Guidonia Montecelio (Roma))</p><p>Dr. Fabio Baroni, biotechnologist by education, holds a PhD in structural biology from the University of Parma (Italy). He is specialized on NMR and spectroscopic techniques applied to protein characterization. In May 2017 he joined Merck Serono as associate researcher, in the Protein Chemistry Department (Rome site, Italy).</p><p><strong>Presenter: </strong>Dr. Christian Fischer (Product Manager of AssureNMR and BiologicsHOS - Senior Staff Scientist, MRS Application Development - Bruker BioSpin GmbH)</p><p>Dr. Fisher has a degree and a PhD in Chemistry from the University of Düsseldorf, Germany. He then joined Bruker in 1999 in the NMR Software Development group. After working on mixture analysis products, he moved into the MRS Application Development. Now he is Product Manager of AssureNMR and BiologicsHOS.</p></blockquote></div></div></div></div></div></div></div></div></div></div></div></div></div></div>

Bruker: Evaluation of Higher Order Structure of Biologics at Atomic Resolution using NMR

Evaluation of Higher Order Structure of Biologics at Atomic Resolution using NMR

The application of 1D and 2D NMR of the intact molecule at isotope natural abundance to routine analyses will be presented.

NMR for Atomic-Level Analysis of Biologic Structures

<p><strong>To thoroughly examine polymer and plastic products for their quality, or to investigate the cause of failure in the event of damage, it is necessary to combine various analytical techniques.</strong><br><br>Using three examples from his daily work at the Luedenscheid Institute of Plastics, Martin Doedt will highlight typical problems in the processing, use and production of plastic products and how macroscopic and microscopic FTIR spectroscopy can help solve them.</p><blockquote><p><strong>Presenter: &nbsp;</strong>Martin Doedt</p><p>Martin Doedt is divisional director for analysis technology at the Luedenscheid Institute of Plastics (Kunststoff Institut Lüdenscheid) and will talk in detail about the methodical approach to failure analysis, starting with the description of the material defect up to the recommendation to the customer to avoid disturbances in production and processing in the future.</p></blockquote>

Bruker: Failure and Damage Analysis in Polymer Industries

Failure and Damage Analysis in Polymer Industries

Martin Doedt shares examples of plastic issues in processing and production, showing how macro and micro FT-IR spectroscopy help solve common problems.

<div><div><div><div><div><div><div><div><div><p><strong>A number of reactions will be discussed, including the challenges faced in the trifluoromethylation reaction, which is sensitive and extremely fast, making it difficult to reliably control the reaction and measure the kinetics. Professor Lloyd-Jones will explain how SF-FT-IR and SF-NMR can be used to address this and enable rapid, reproducible monitoring, along with accurate temperature control.</strong></p><p>Professor Lloyd-Jones will also introduce InsightXpress, which he has developed in collaboration with TgK Scientific and Bruker and has been critical to understand the mechanisms of the Suzuki-Miyaura protodeboronation side reaction. The InsightXpress SF unit enables fast reactions to be monitored and reaction conditions to be automatically screened by NMR at unprecedented speeds. With the InsightXpress, not only is accurate temperature control possible, but large reagent volumes are not needed and mixing is so efficient that analysis can begin very shortly after the start of the reaction. Importantly, unlike classic SF systems, the concentration of the reagents can be varied rather than it being fixed in the initial set-up, which vastly broadens scope in terms of mapping out the kinetics and screening reaction conditions in process chemistry.</p><p>Professor Lloyd-Jones and team have also developed an SF-FT-IR system in collaboration with Bruker and TgK Scientific that will be introduced during the seminar. This device offers the same capabilities as the InsightXpress, but is interfaced with a VERTEX 80 Fourier transform infrared spectrometer instead of an NMR spectrometer.</p><p>The protodeboronation reaction will also be covered. This reaction, which is usually undesirable, reduces yields in Suzuki-Miyaura couplings. SF-NMR and SF-FT-IR have enabled mechanistic understanding of protodeboronation by allowing the concentration of reactants to be measured as a function of time when reactions are extremely fast and highly sensitive to pH. Using these techniques, it has been possible to accurately and rapidly initiate these reactions and maintain good control of pH so that they can be accurately monitored. Some of the reagents monitored by SF-IR have half-lives of milliseconds. These are reactions that would otherwise be over almost as soon as the reactants have been mixed.</p><h5><strong>Key Topics</strong></h5></div><div><div><div><div><div><div><ul><li>Understanding the basic principles of SF and how it can be improved to make a variable ratio SF system</li><li>How those SF systems have been interfaced with FT-IR and NMR spectrometers and the technical challenges and benefits</li><li>Example applications of how SF-IR and SF-NMR can be used</li></ul><h5><strong>Who Should Attend?</strong></h5></div></div></div></div></div><div><div><div><div><div><div><p>As well as welcoming the spectroscopy community in general, this webinar is aimed at any synthetic or process chemist in pharma, other industries and in academia who are interested in reaction understanding and optimization.</p><blockquote><p><strong>Presenter: </strong>Guy Lloyd-Jones (Forbes Professor of Organic Chemistry School of Chemistry University of Edinburgh Scotland)</p><p>Guy Lloyd-Jones studied Chemical Technology (BSc. 1989) at Huddersfield, and spent a year placement at ICI Pharmaceuticals (now AstraZeneca) in 1987. He obtained his doctorate in organic chemistry (D. Phil. 1992) at Oxford University under John Brown FRS, and conducted postdoctoral research (1993-1995) in asymmetric catalysis at Basel University, with Andreas Pfaltz. In 1996 he returned to the UK, to a lectureship at the University of Bristol and began to build a research group specialising in organic / organometallic stereochemistry, in particular applying NMR and isotopic labelling. He was promoted to Full Professor in 2003, held a Royal Society Wolfson Research Merit Award 2008- 2013, and was Head of Organic and Biological Chemistry at Bristol 2012-2013. In 2013 he moved from Bristol to The Forbes Chair of Organic Chemistry at the University of Edinburgh. In the same year was elected a fellow of the Royal Society (FRS) and and ERC Advanced Investigator. At Edinburgh he and his group continue to build their expertise in the study of reaction mechanism and reactivity relationships in the context of synthetic methodology and catalysis. Intrinsic to this is application and development of physical-organic chemistry methodologies, and associated instrumentation for its analysis.</p></blockquote></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div>

Bruker: Improving Mechanistic Understanding of Fast Reactions Using Rapid, Reproducible in Situ Analysis by Stop-flow NMR and IR

Improving Mechanistic Understanding of Fast Reactions Using Rapid, Reproducible in Situ Analysis by Stop-flow NMR and IR

Prof. Lloyd-Jones shows how SF-FT-IR and SF-NMR allow fast, reproducible monitoring of sensitive reactions like trifluoromethylation with temp control.

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