<h4>The problem&nbsp;</h4>We live in a “global village” but we are all different and we use many different languages to communicate.&nbsp;Even when people speak the same language, the same words may be used with different meanings. See, for example, some different uses of the word “standard” in English – a normative document, a solution of known concentration or even a type of flag.&nbsp;Even in the same area of activity misunderstandings do occur which may result in a waste of time and money, or even worse consequences.&nbsp;When talking about laboratory tests, lack of a full understanding of key terms and inappropriate translations leaves room for different interpretations of stated requirements. For example, there have historically been a number of different but related uses of the term ‘detection limit’. This may lead to inadequate fulfilment of those requirements, thus becoming an obstacle to the production of analytical data that is fit for its intended use. A shared interpretation of concepts related to quality in measurement between laboratories and accreditation bodies is also crucial for a fair and harmonised approach to laboratory assessment across the world.&nbsp;<h4>A common language&nbsp;</h4>We need a common language; clear and unambiguous. We need a common vocabulary to provide consistent definitions of concepts with their associated terms. To this end, several organisations participate in a joint effort to develop and maintain an international vocabulary of metrology (VIM) [1], which aims to achieve a unique understanding of concepts related to measurements across all sectors. The VIM is a normative reference in the standards ISO/IEC 17025, ISO 15189 and ISO/IEC 17043, and is therefore a key document for all organisations seeking accreditation.&nbsp;<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Eurachem_You_talk_we_understand_The_way_out_of_the_tower_of_Babel_Standards_8d947dbd5f.jpg" alt="Eurachem: You talk, we understand – The way out of the tower of Babel_A common language" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Eurachem_You_talk_we_understand_The_way_out_of_the_tower_of_Babel_Standards_8d947dbd5f.jpg 245w," sizes="100vw" width="1126" height="499"><h4>Is this enough?&nbsp;</h4>For laboratory staff some problems still stand and need to be addressed:&nbsp;<ul><li>Many people are confused about both concepts and terms.&nbsp;</li><li>It may be difficult to understand the “formal” VIM definitions – they are short statements intended to apply to many different measurement sectors.</li><li>Translations into local languages may add to the confusion, e.g. if different terms are used in different sectors for the same VIM concept and the translator overlooks this issue.</li><li>Some substantial changes to terminology have been made in an attempt to accommodate chemical and biological measurements. Some “old” concepts still stand but have new names, e.g. “within laboratory reproducibility” vs. “intermediate precision”.&nbsp;</li></ul>To address these issues Eurachem has produced a guide [2] which provides an accessible reference containing simple and in context explanations of terms most relevant to analysts, with additional examples relating those concepts to chemical and biological measurements.&nbsp;<h4>Do you understand the meaning of these terms?&nbsp;</h4>Are you interested in a quantity or a quality? Depending on the answer, will you use a measurement procedure or an examination? Is method verification the same or less demanding than method validation? Do you need a calibration or just performance verification? Do you have a measurement standard in your laboratory? Is metrological traceability something you worry about? These are examples of the terms supporting the reliability of any measurement result that need to be clearly understood.&nbsp;<h5>Example – Accuracy, trueness, precision: are they synonyms?&nbsp;</h5><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Eurachem_You_talk_we_understand_The_way_out_of_the_tower_of_Babel_accuracy_231e1e005e.jpg" alt="Eurachem: You talk, we understand – The way out of the tower of Babel_Example – Accuracy, trueness, precision" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Eurachem_You_talk_we_understand_The_way_out_of_the_tower_of_Babel_accuracy_231e1e005e.jpg 146w," sizes="100vw" width="754" height="807"><ul><li>Closeness between measurement results (relating to the concept of precision)</li><li>Closeness of the average of the measurement results to a reference value (relating to the concept of trueness)&nbsp;</li><li>Closeness of an individual measurement result to the true value (relating to the concept of accuracy)&nbsp;</li></ul>The different situations in the figure show the effect of:&nbsp;<ol style="list-style-type:lower-latin;"><li>poor precision and trueness (imprecise and biased)&nbsp;</li><li>good precision, poor trueness (precise but biased)&nbsp;</li><li>poor precision, good trueness (imprecise but unbiased)&nbsp;</li><li>good precision and trueness (precise and unbiased)&nbsp;</li></ol>Improving both precision and trueness is expected to improve accuracy.&nbsp;<h4>Is all this relevant to you?&nbsp;</h4>Do you work in a laboratory, either as an analyst, quality manager or director? Are you involved in other activities related to analytical work, such as providing proficiency tests, producing reference materials or accrediting any such activity? Do you teach or study subjects related to measurements? Do you use measurement results or prescribe how to use them? If the answer is yes to any of these questions, the following reference documents are also for you.

You talk, we understand – The way out of the tower of Babel

Visit the LabRulez booth at <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/events/871">analytica 2026</a> in Munich, 24. - 27. March 2026! You can find us in Hall A1, Booth A1.506. At the booth, you will be able to explore live demonstrations of how the LabRulez portals work and see selected analytical instruments from our pre-owned marketplace section.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Lab_Rulez_at_Analytica_2026_Floor_plan_55e1057e03.jpg" alt="LabRulez at Analytica 2026: Hall A1 Floor Plan and Booth Location" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Lab_Rulez_at_Analytica_2026_Floor_plan_55e1057e03.jpg 245w," sizes="100vw" width="1516" height="881"><h3>Would you like to learn how the LabRulez portals work?</h3>➡︎ <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/">LabRulezLCMS</a> ➡︎ <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/">LabRulezGCMS</a> ➡︎ <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/">LabRulezICPMS</a><ul><li>A unique online solution for your marketing</li><li>A targeted audience from the analytical chemistry community</li><li>Modern technologies and a unique concept</li><li>Design optimized for most smart devices – PC, mobile, and tablet</li><li>Advanced statistical tools fully available to users</li></ul><h3>Services Offered</h3><h4>News + Company Updates</h4><ul><li>Publish news related to your instrumentation, applications, services, events, job openings, and more</li><li>News is shared both on our portals and across our social media channels</li></ul><h4>Library – All Documents in One Place</h4><ul><li>Applications, posters, presentations, technical articles, brochures, specifications</li><li>Fast and advanced search capabilities</li><li>Over 32,000 documents currently available in our database</li></ul><h4>Webinars</h4><ul><li>Upcoming and on-demand webinars from the field of analytical chemistry</li><li>More than 5,500 webinars covering chromatography, mass spectrometry, and spectroscopy</li></ul><h4>Careers</h4><ul><li>Targeted job listings in analytical chemistry</li><li>Clear filtering by specialization or location</li><li>Increased visibility for job postings</li></ul><h4>Companies</h4><ul><li>Company profile with key information and contacts</li><li>Integration of all your activities on our portal: News, Library documents, Webinars, Upcoming Events, Careers, and mentions by partners or customers</li><li>Connection to your Products listed on LabRulez portals</li></ul><h4>Products and Services</h4><ul><li>Comprehensive overview of instrumental techniques and services</li><li>Targeting the analytical chemistry community and customers in the growing online environment</li></ul><h4>Marketplace</h4><ul><li>Buying and selling pre-owned analytical equipment</li><li>We purchase analytical instrumentation of all brands and ages</li><li>Sell your equipment through LabRulez</li><li>Request and purchase complete systems, modules, or spare parts with warranty and service</li></ul><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Lab_Rulez_at_analytica_2026_bazar_7edf4a0872.jpg" alt="LabRulez at analytica 2026" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Lab_Rulez_at_analytica_2026_bazar_7edf4a0872.jpg 88w," sizes="100vw" width="1600" height="2844"><h3>What Will Be on Display at Our Booth?</h3>Come and explore selected spare parts and modules from our marketplace section. These include both new, tested, and pre-owned items.<h4><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/bazaar">LabRulezLCMS Marketplace</a></h4>Spare parts for LC/MS:<ul><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/bazaar?category=378">Vacuum turbo pumps for LC/MS</a></li></ul>Spare parts for HPLC:<ul><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/bazaar?category=397">Degassers for HPLC/UHPLC</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/bazaar?category=368&amp;search=valve">Automatic valves for HPLC</a></li><li>HPLC components for Agilent 1100, 1200, and 1260 Infinity II series</li></ul>Consumables:<ul><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/bazaar?category=377">HPLC lamps</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/bazaar?category=48">HPLC columns</a></li></ul><h4><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/bazaar">LabRulezGCMS Marketplace</a></h4>Spare parts for GC/MS:<ul><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/bazaar?category=367&amp;search=turbo">Turbo pumps for GC/MS</a></li></ul>Spare parts for GC:<ul><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/bazaar?category=366&amp;search=EPC">EPC modules</a></li></ul>Sample injection<ul><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/bazaar/432">Autosampler 7693A for GC</a></li></ul>Consumables:<ul><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/bazaar?category=7">GC columns </a>and selected accessories</li></ul>

LabRulez at analytica 2026

Our Library never stops expanding. What are the most recent contributions to LabRulezICPMS Library in the week of 23rd March 2026? Check out new documents from the field of spectroscopy/spectrometry and related techniques!<blockquote>👉 <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/library">SEARCH THE LARGEST REPOSITORY OF DOCUMENTS ABOUT SPECTROSCOPY/SPECTROMETRY RELATED TECHNIQUES</a></blockquote><blockquote>👉 Need info about different analytical techniques? Peek into <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/library">LabRulezLCMS</a> or <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library">LabRulezGCMS</a> libraries.</blockquote>This week we bring you application notes by LECO, Shimadzu and Waters Corporation and brochure by Thermo Fisher Scientific!<h3>1. LECO: Determination of Nitrogen in Fertilizer</h3><ul><li>Application note</li><li><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/labrulez-bucket-strapi-h3hsga3/CN_FP_928_NITROGEN_FERTILIZERS_203_821_615_4d4b013a08.pdf">Full PDF for download</a></li></ul>Nitrogen is one of the most important elements for plant development and is the macronutrient that is most often found to be deficient in arable soils used for crop production. Nitrogen plays a key role in the formation of enzymes and proteins, which promotes lush, vigorous growth and development in plants that often leads to an increase in the yield from the plant. Fertilizers are utilized to re-introduce nitrogen back into arable soils. Fertilizers can be grouped by their makeup and/or origins into categories including inorganic and/or synthetic (including nitrates, ammonium, and urea) and organic (including compost materials and manures). The accurate and precise determination of nitrogen in all fertilizer types is not only important in the process of blending and preparing the fertilizer material for use, but also will have significant impact on the commercial value and guarantee of the fertilizer.&nbsp;The CN928/FP928 is a macro combustion carbon and nitrogen/protein determinator that utilizes a pure oxygen environment in a high-temperature horizontal ceramic combustion furnace designed to handle macro sample mass. A thermoelectric cooler removes moisture from the combustion gases before they are collected in a ballast. The gases equilibrate and mix in the ballast before a representative aliquot (3 cm3 or 10 cm3 volume) of the gas is extracted and introduced into a flowing stream of inert gas (helium or argon) for analysis. The aliquot gas is carried to a thermal conductivity cell (TC) for the detection of nitrogen (N2).<h4>Instrument Model and Configuration&nbsp;</h4>Thermal conductivity detectors work by detecting changes in the thermal conductivity of the analyte gas compared to the constant thermal conductivity of the reference/carrier gas. The greater the difference between the thermal conductivity of the carrier gas and the analyte gas, the greater the sensitivity of the detector. The <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/library?mainauthorItems=24&amp;search=CN928">CN928</a>/<a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/library?mainauthorItems=24&amp;search=FP928">FP928</a> supports either the use of helium or argon as the instrument's carrier gas. When used as a carrier gas, helium provides the highest sensitivity, and the best performance at the lower limit of the nitrogen range. The thermal conductivity difference between argon and nitrogen is not as great as the thermal conductivity difference between helium and nitrogen, therefore the detector is inherently less sensitive when using argon as a carrier gas.<h4>TYPICAL RESULTS&nbsp;</h4>Data was generated utilizing a single standard, forced through origin calibration using ~ 0.1 g of NIST 913b Uric Acid (33.23% N). Alternatively, LECO 503-530 LCRM Urea may be used for calibration.<h3>2. Shimadzu: Evaluation of Microscopic Foreign Matter in Recycled Plastics Using Dynamic Image Analysis, Infrared Microscopy, and SEM-EDS</h3><ul><li>Application note</li><li><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/labrulez-bucket-strapi-h3hsga3/an_01_00861_en_7485baba21.pdf">Full PDF for download</a></li></ul><h4>User Benefits</h4><ul><li>&nbsp;It is easy to evaluate the size and quantity of microscopic foreign particles, which are key quality criteria of recycled plastics.</li><li>With the microcell method of DIA, microscopic foreign matter can be detected and counted quickly using a small sample quantity.</li><li>Infrared microscope and SEM-EDS systems provide information about the morphology and composition of microscopic foreign matter that is useful for improving recycling processes.</li></ul>One of the quality criteria for recycled plastic flakes and pellets is the content of foreign matter. Quantitatively evaluating the size and quantity of foreign particles contained in flakes and pellets is important for examining foreign matter removal processes intended to improve pellet quality and optimize manufacturing processesfor products made with recycled materials.&nbsp;In this article, pellets of virgin and recycled polyethylene terephthalate (hereafter PET) were dissolved in hexafluoro-2-propanol (hereafter HFIP), a solvent for dissolving PET, to prepare suspensions of insoluble microscopic foreign particles. These suspensions were measured with a dynamic particle image analysis (DIA) system (<a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/library?mainauthorItems=1&amp;search=iSpect+DIA-10">iSpect DIA-10</a>) to evaluate the size and number of insoluble microscopic foreign particles (patent pending). In addition, part of the suspensions were diluted tenfold and filtered through a membrane filter to collect the insoluble microscopic foreign particles on the filter. The morphology and composition of the collected microscopic foreign particles were evaluated using a digital microscope, an infrared microscope system (<a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/library?mainauthorItems=1&amp;search=IRTracer-100">IRTracer-100</a> and <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/library?mainauthorItems=1&amp;search=AIM-9000">AIM-9000</a>), and an SEM-EDS system. These evaluations enabled comparison of the sizes, quantities, and types of foreign particles contained in virgin and recycled materials.<h4>Conclusion&nbsp;</h4>By using an iSpect DIA-10 system to measure suspensions prepared by dissolving two types of PET pellets (virgin and recycled) in HFIP, we obtained particle images of insoluble foreign matter and evaluated size and concentration of particles. That enabled quantitative comparison of particle size and count in microscopic foreign matter contained in virgin and recycled materials.&nbsp;In addition, after diluting the pellet suspensions, the insoluble microscopic foreign matter in the diluted suspensions was collected on filters. The morphology and composition of the microscopic foreign matter were evaluated using an infrared microscope and SEM-EDS system. The results indicated that the suspensions contained organic substances, such as cellulose and amide-based compounds, and inorganic substances and metals that contain elements such as C, O, Ca, and Al (suggestive of carbonates and metallic aluminum).&nbsp;Thus, the iSpect DIA-10 enables simple quantitative evaluation of the size and number of microscopic foreign particles in PET pellets using only small sample quantities. Furthermore, composition evaluation by infrared microscope and SEM-EDS systems provides useful information for investigating the origin of foreign matter, examining measures to reduce foreign matter, and evaluating impacts on final products. If similarities in size and shape are observed, particle images obtained with iSpect DIA-10 can also potentially be used to estimate particle composition.<h3>3. Thermo Fisher Scientific: Ensuring safer and effective pharmaceutical formulations by X-ray diffraction</h3><ul><li>Brochures and specifications</li><li><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/labrulez-bucket-strapi-h3hsga3/PF_41381_xrd_solutions_pharma_9b89684165.pdf">Full PDF for download</a></li></ul>From drug discovery and preformulation studies to the efficient scaling up in the manufacturing process in the plant and finally through QA/QC validation, X-ray diffraction (XRD) is a vital analysis method in the characterization of different physico-chemical properties of the active pharmaceutical ingredient (API). XRD is a gold standard method and required technique in the determination of polymorphic and salt screening, % of crystallinity and stability/reactivity studies of the final API.&nbsp;<h5><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/products/2297">Thermo Scientific™ SolstiX™ XRD Software</a> with Security Suite extends ARL EQUINOX 100 X-ray Diffractometers to 21 CFR Part 11 regulated labs&nbsp;</h5><ul><li>Protect stored electronic data related to quality assurance within manufacturer’s computer systems&nbsp;</li><li>Put controls in place to keep records authentic, incorruptible, and confidential&nbsp;</li><li>Electronic signatures for the user to take responsibility for the electronic data in the system&nbsp;</li><li>Requirements in the data record: date and time of scan, name of the unique signer, and technological controls to ensure security (e.g. passwords)&nbsp;</li></ul><h5><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/products/2143">Thermo Scientific™ ARL™ EQUINOX 100 X-ray benchtop diffractometer</a> is designed to exceed your analytical needs&nbsp;</h5><ul><li>Ideally suited for rapid screening of various formulations, finger printing or detection of counterfeit products&nbsp;</li><li>Polymorphism and crystallinity determination, crystallite size calculation, quantitative phase analysis, reactivity and stability of materials, etc.&nbsp;</li><li>XRD experiments on standard powders, bulks, tablets, small quantities, etc.&nbsp;</li><li>Real-time full pattern XRD based on our unique PSD detector technology&nbsp;</li><li>X-ray source based on micro-source technology with no external water cooling</li><li>Unique dual-mode capability: reflection and/or transmission&nbsp;</li></ul><h5>Thermo Scientific™ ARL™ EQUINOX 100 XRD for structural analysis&nbsp;</h5><ul><li>Easy-to-use simultaneous full pattern XRD based on unique real time PSD detector technology&nbsp;</li><li>Unique dual-mode capability on a benchtop XRD instrument: reflection and/or transmission mode&nbsp;</li><li>XRD experiments on various samples with sample spinner, capillary stage, sample changer or in controlled environment</li></ul><h5>Top XRD benefits for pharma&nbsp;</h5><ul><li>Structural characterization technique&nbsp;</li><li>Nondestructive technique&nbsp;</li><li>Small amount of sample needed for analysis&nbsp;</li><li>Unique diffraction patterns and quick response&nbsp;</li><li>Analysis on mixtures as well as amorphous content&nbsp;</li><li>Easy determination of induced structural changes</li></ul><h3>4. Waters Corporation: SIMI: A Different Approach to Revealing Dangerous Subvisible Impurities</h3><ul><li>Application note</li><li><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/labrulez-bucket-strapi-h3hsga3/720009094_en_fb955e89ec.pdf">Full PDF for download</a></li></ul>Foreign particulate matter, also known as extrinsic particles, has become a serious threat to patient safety in recent years, with cases linked to severe immunogenic reactions, deaths, and costly recalls.1 In 2021 alone, Takeda recalled 1.6 million doses of the Moderna COVID-19 mRNA vaccine in Japan after several patient deaths were linked to steel particulates shed from a malfunctioning pump.2 Over the span of seven years, from 2014–2017, there were more than 110 drug recalls as a result of glass delamination,3–4 and several more due to remnant crystals,5 owing to the difficulty of identifying the presence and source of foreign particulate matter. To prevent against such threats, manufacturers require high throughput technologies to better identify foreign particulate matter in real time.<h4>Results and Discussion</h4><h5>Shining a Light on Extrinsic Particles with SIMI</h5>Side illumination membrane imaging (SIMI) is a proprietary illumination, imaging, and analysis technique exclusively available to <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/products/2190">Aura instruments</a>. Utilizing the principles of darkfield microscopy,6 SIMI is conducted on an Aura membrane plate using an oblique illumination source which emits light at an angle parallel to the surface of the plate.&nbsp;Compared to backgrounded membrane imaging (BMI), which utilizes brightfield microscopy (epi-illumination) where particles scatter the incident light isotropically (i.e., at all angles), side illumination membrane maging (SIMI) is a technique that is specifically designed to detect light scattering from high refractive index particles, as well as those that protrude out of the plane from the membrane surface. A particle’s average SIMI intensity is measured in a relative scale where the inherent SIMI scattering of the membrane is defined as SIMI = 0. Positive SIMI values indicate particles protruding out of the membrane, as is the case with microplastics, fibers, and other common extrinsic particles, whose average SIMI intensities vary from 0–255. On some occasions, like with metallic particles and absorbing oils, particles will have reduced light refraction relative to the membrane and thus display negative SIMI values, varying from 0 to -122.&nbsp;The majority of foreign, extrinsic particles exhibit a high refractive index and are mechanically rigid in structure, causing them to protrude from the membrane surface and scatter side illumination to a high degree, ideal for SIMI analysis. In contrast, biologic particles exhibit the opposite properties—low refractive index and malleable structures, causing them to lie flat with minimal side scatter profiles, which is best analyzed with BMI or fluorescence membrane microscopy (FMM). Utilizing all three microscopy approaches is most ideal to facilitate the determination of all extrinsic (non-biologic) and inherent (biologic) particles in biologic formulations.<h4>Conclusion&nbsp;</h4>SIMI is a unique approach to providing additional characterization of subvisible particles and is available in all Aura models to help rapidly identify foreign material in biological samples with a high degree of specificity. A key tertiary imaging mode in addition to BMI and FMM, SIMI provides selective, orthogonal morphological information to identify tall and rigid materials, a defining feature of most extrinsic particles (Figure 11). While particle sizing and counting is done via BMI, SIMI provides illumination, imaging, and analysis that can be useful across a variety of biological products to reveal foreign subvisible particles from the earliest to the latest of stages in the bioprocess.

News from LabRulezICPMS Library - Week 13, 2026

Article

Events

Application

Science and research

Eurachem is a European network promoting international traceability of chemical measurements and good analytical practice. It provides expert guidance, supports method validation, uncertainty evaluation, proficiency testing, and facilitates discussion on technical and policy issues in analytical quality.

Eurachem

Everything from the world of analytical chemistry in one place. We connect people in solving their problems. At Labrulez you will find all the necessary information easily, quickly and clearly. Stop searching and start finding.

LabRulez

Agilent Technologies

Thermo Fisher Scientific

Business Review Webinars

A calibration curve or regression is always plotted with the instrument responses on the dependent vertical (y -) axis and the standard concentrations on the horizontal (x -) axis. As a linearity of calibration regression minimizes random errors of the instrument, we aim to find the best straight line to pass through these calibration points.
<ul>
<li>What are the estimated errors and confidence limits we can estimate for the slope (or gradient) and the y-intercept of the line?
</li>
<li>What is the uncertainty of the analyte concentration found on the calibration curve?
</li>
<li>What are the least concentration of the measurand can be detected with, say 95% confidence?
</li>
<li>In other words, what is the limit of detection (LOD) of this method?
</li>
</ul>
This one-day training program is designed to answer all the above questions and others related to the subjects of linear regression of instrument calibration and detection limits including IDL, MDL and LOQ.
<h3>Training Program (8:00 - 10:30 CEST)</h3>
<ul>
<li>Introduction</li>
<li>Different meanings for correlation and regression</li>
<li>Assumptions of linear regression and correlation</li>
<li>Residual analysis – what and how</li>
<li>Uncertainty estimation of linear calibration regression</li>
<li>Must your linear regression always pass through its origin (0,0)?</li>
<li>The most controversial subject in analytical chemistry – Limit of Detection LOD</li>
<li>Different definitions for LOD and its basic concepts</li>
<li>Differences between IDL, MDL, LOQ</li>
<li>Determining LOD by linear calibration model</li>
</ul>
<h5>Who should attend:</h5>
This course is designed for those who want to know more about the sampling procedures and how it affects the validity of their test results, including:
<ul>
<li>Laboratory analysts</li>
<li>Laboratory QA/QC personnel</li>
<li>Lab directors / managers</li>
<li>Personnel who carry out tasks such as method validation and uncertainty estimation</li>
</ul>
<h5>Pre-requisites</h5>
The participants are assumed to have had some basic statistical knowledge such as the calculation of mean, standard deviation, coefficient of variation, relative standard deviation, etc.
Participants are to have a laptop with Microsoft Excel installed and have some very basic knowledge of how to use the program.
<blockquote>
Presenter: Yeoh Guan Huah
</blockquote>
<blockquote>
Mr Yeoh Guan Huah has B.Sc. (Hons) and M.Sc. degrees in Chemistry and was former Managing Director of ALS Technichem Singapore (1978-2006), former East Asia Regional Manager of ALS Group of Laboratories in Hong Kong and China (2006-2016). He is now the senior partner of GLP Consulting, Singapore.
</blockquote>
<blockquote>
Currently Mr Yeoh is an appointed External Lead Assessor and Technical Assessor of SAC-SINGLAS till 31 March 2025 and had represented DSM/SIRIM Malaysia as a active member of ISO Technical Committee TC 69 (Application of Statistical Methods) and Convenor of AHG1 from 2005-2016.
</blockquote>

Agilent Technologies: Uncertainty of Linear Calibration Curve & Detection Limit

Uncertainty of Linear Calibration Curve & Detection Limit (Part 1)

We will answer all questions related to the subjects of linear regression of instrument calibration and detection limits including IDL, MDL and LOQ.

Uncertainty of Linear Calibration Curve & Detection Limit

A UV-VIS spectrometer is a powerful and versatile tool for material analysis. It is capable of providing very quick information of sample composition and concentration for quality control in addition to indicating how samples change versus time or temperature.
In this webinar, we will go over what is happening when we take a UV-VIS measurement, discuss how measurement parameters can improve our data collection, and look at applications like concentration and kinetics.
<blockquote>
Presenter: Scott Melis, PhD (Application Scientist, Agilent Technologies, Inc.)
</blockquote>
<blockquote>
Scott Melis has a PHD in Physics from Georgetown University in Washington, DC and started with Agilent in 2021 as a Molecular Spectroscopy Application Scientist. In his graduate work, Scott studied nanoparticle formation and growth for a variety of applications. Projects that he worked with include developing processes to deposit and characterize semiconducting molecular nano-cocrystals for use in optoelectronic devices as well as controlling polymer nanoparticle size through rapid mixing conditions.
</blockquote>

Agilent Technologies: Understanding Your UV-Vis Measurements

Understanding Your UV-Vis Measurements

What is happening when we take a UV-VIS measurement, how measurement parameters can improve our data collection, and look at applications.

Contamination is one of the most common causes of deteriorated product quality and equipment performance in industrial environment. FTIR has been proven to be a valuable tool to characterize the contamination rapidly and economically. Agilent’s compact and portable FTIR spectrometers provide a complete product portfolio with versatile sampling interfaces and spectral process capabilities, which can offer great convenience, stability and high-throughput solution to the contamination-related applications.
This online seminar provides a comprehensive introduction to the FTIR testing technology in the contamination-related applications.
<blockquote>
Presenter: Yanqia Wang, PhD (Application Engineer, Molecular Spectroscopy, Agilent Technologies, Inc.)
</blockquote>
<blockquote>
Dr. Yanqia Wang started working for Agilent Technologies Inc. as a FTIR application Engineer in 2013, providing pre-&amp;post-sale application support. The products he covers from Bench-top FTIR microscopes to various Mobile FTIR spectrometers. Dr. Wang received his PhD of analytical chemistry from Duke University in 2004, doing dynamic IR spectroscopy research. Then he joined Fitzpatrick Center for Photonics at Duke University, doing Tissue Raman spectrometer instrumentation. Since 2007, Dr. Wang worked for Avery Dennison Corp. as a spectroscopist, providing molecular analytical support to the research &amp; development.
</blockquote>

Agilent Technologies: Contamination Study with FTIR

Contamination Study with FTIR

 This online seminar provides a comprehensive introduction to the FTIR testing technology in the contamination-related applications.

This webinar will discuss accuracy and precision and how to ensure both. We will show live examples of precision examples and how to improve it. For accuracy we will show techniques like internal standards, standard addition, dilutions, duplicates, spikes and spike recoveries, second source standard type and there uses.
 
<blockquote>
Presenter: Paul Krampitz (Application Scientist, Agilent Technologies, Inc.)
</blockquote>
<blockquote>
Graduate of Bowling Green State University with a Chemistry Bachelor of Science degree. Twenty – five years of Spectroscopy experience mainly Inductively Coupled Plasma (ICP) Spectroscopy as well as ICP-MS and AAS. Experience also includes X-Ray Fluorescence (ED, WD), Laser Ablation, Inorganic Speciation and Microwave Plasma Spectroscopy. Market Segment expertise includes environmental, petrochemical, metallurgical applications.
</blockquote>

Agilent Technologies: Learn how to Confirm your Data on ICP-OES. Are you getting the Right Result? Are You Sure? 

Learn how to Confirm your Data on ICP-OES. Are you getting the Right Result? Are You Sure? 

This webinar will discuss accuracy and precision and how to ensure both.

Learn how to Confirm your Data on ICP-OES

In this first part of our two-part educational webinar, we will take you through the main considerations of sample prep and sample introduction techniques.
We will also discuss plasma effect and instrumentation maintenance. 
This session “From sample prep to data evaluation using ICP-OES and ICP-MS” will cover:
<ul>
<li>Sample Prep – creating serial dilutions from stock standards
</li>
<li>Sample introduction options and considerations – matrix matching, physical and chemical interferences
</li>
<li>Inductively Coupled Plasma – RF, plasma effects
</li>
<li>ICP-OES and ICP-MS cleaning and maintenance
</li>
<li>ICP-OES and ICP-MS theory of operation
</li>
</ul>
Learning points:
<ul>
<li>Learn theoretical and practical fundamentals for daily operation with ICP-OES and ICP-MS
</li>
<li>Learn about sample preparation, sample introduction and plasma settings to integrate and optimize this technology in your routine analysis
</li>
<li>Learn tips and trick for cleaning and maintenance to improve your analytical performance
</li>
</ul>
Who should attend:
<ul>
<li>Laboratory managers and analysts who work with ICP-OES and ICP-MS systems
</li>
<li>Analysts who want to learn about sample prep, sample introduction and instrument maintenance
</li>
<li>Laboratory leaders who want to leverage the full potential of their instrument
</li>
</ul>
<blockquote>
Presenter: Matthew Gregory (Specialist, Sales Support, TEA &amp; DIA, UK &amp; Ireland, Thermo Fisher Scientific)
</blockquote>
<blockquote>
After graduating from the University of Surrey with an MChem in Chemistry, Matthew has gained 15 years’ experience of trace elemental analysis in industry, working in environmental and precious metal research laboratories. In 2018 Matthew joined Thermo Fisher Scientific as an Applications Specialist for the Trace Elemental Analysis product range in the UK and Ireland.
</blockquote>
<blockquote>
Presenter: Niel Williams (Specialist, Sales Support, TEA &amp; DIA, UK &amp; Ireland, Thermo Fisher Scientific)
</blockquote>
<blockquote>
After graduating in 2014, Niel first joined Teledyne Advanced Chemistry systems as an applications specialist and later technical sales specialist. In 2019, he took the role of applications specialist for the Trace Elemental Analysis product range in the UK and Ireland at Thermo Fisher Scientific. Niel holds a BSc in Geology and Planetary science and a PhD in Isotope Geochemistry from the University of Manchester.
</blockquote>

Thermo Scientific: Introduction to ICP spectrometry: Part 1

Introduction to ICP spectrometry: Part 1

The main considerations of sample prep and sample introduction techniques.

In our second part of this educational webinar, we will show you various tips and tricks for performance optimization, method development and data handling.
The session &quot;From sample prep to data evaluation using ICP-OES and ICP-MS&quot; will cover: 
<ul>
<li>System Optimization – Performance reports, Mass Cal/Cross Cal, KED interface cleaning, Conditioning
</li>
<li>Method development – Correct wavelength/viewing mode and isotope selection, interferences – spectral and m/z, determine correct internal standards to use and validation of method
</li>
<li>Data evaluation – correcting for background and interferences, stability, and sensitivity verification, Examine calibration curves for R2, LOD and saturation, QC data, carryover and drift correction
</li>
</ul>
Learning points:
<ul>
<li>Learn theoretical and practical fundamentals for daily operation with ICP-OES and ICP-MS
</li>
<li>Learn about system optimization, method development and data evaluation to integrate and optimize this technology in your routine analysis
</li>
<li>Learn tips and trick for cleaning and maintenance to improve your analytical performance
</li>
</ul>
Who should attend:
<ul>
<li>Laboratory managers and analysts who work with ICP-OES and ICP-MS systems
</li>
<li>Analysts who want to learn about sample prep, sample introduction and instrument maintenance
</li>
<li>Laboratory leaders who want to leverage the full potential of their instrument
</li>
</ul>
<blockquote>
Presenter: Niel Williams (Specialist, Sales Support, TEA &amp; DIA, UK &amp; Ireland, Thermo Fisher Scientific)
</blockquote>
<blockquote>
After graduating in 2014, Niel first joined Teledyne Advanced Chemistry systems as an applications specialist and later technical sales specialist. In 2019, he took the role of applications specialist for the Trace Elemental Analysis product range in the UK and Ireland at Thermo Fisher Scientific. Niel holds a BSc in Geology and Planetary science and a PhD in Isotope Geochemistry from the University of Manchester.
</blockquote>
<blockquote>
Presenter: Matthew Gregory (Specialist, Sales Support, TEA &amp; DIA, UK &amp; Ireland, Thermo Fisher Scientific)
</blockquote>
<blockquote>
After graduating from the University of Surrey with an MChem in Chemistry, Matthew has gained 15 years’ experience of trace elemental analysis in industry, working in environmental and precious metal research laboratories. In 2018 Matthew joined Thermo Fisher Scientific as an Applications Specialist for the Trace Elemental Analysis product range in the UK and Ireland.
</blockquote>

Thermo Scientific: Introduction to ICP spectrometry: Part 2

Introduction to ICP spectrometry: Part 2

Various tips and tricks for performance optimization, method development and data handling.

Extracting the full potential of trace elemental analysis instrumentation to meet regulatory, compliance and performance requirements: Part 1 ICP-OES
Join this virtual demonstration of the Thermo Scientific iCAP PRO Series ICP-OES to learn how to easily meet and surpass regulatory requirements for your trace elemental analysis. In this online seminar we will focus on three key markets and demonstrate how the hardware and software of the iCAP PRO enhance performance and simplify your analysis.
The three markets covered are: 
Environmental – Discover how enhanced detector capabilities and optical design allow class leading detection limits and speed of analysis to be achieved. Comprehensive quality control features within the software simplify data validation. 
Precious metals – With its new vertical torch design and higher resolution camera, better robustness and signal stability are obtained with the iCAP PRO. Automated interelement interference workflows with customizable limits add enhanced accuracy and flexibility for your analysis. 
Wear metals and lubricants – Improved system robustness and speed of analysis enable longer run times between maintenance for oil-based samples. 
This online seminar will conclude with a short panel discussion around the new regulations within each market and how the instrument hardware and software features future-proof your laboratory. 
Learning points:
<ul>
<li>Discover how the new hardware of the iCAP PRO provides you with class leading performance.
</li>
<li>Learn about modern software tools to integrate this technology into your routine analysis and simplify compliance with market regulations.
</li>
<li>Find out how instruments from Thermo Fisher Scientific future-proof your lab, preparing you for stricter regulations with ever decreasing limits of detection, higher accuracy and better stability requirements.
</li>
</ul>
Who should attend? 
<ul>
<li>Laboratory managers and analysts who work with ICP-OES systems. 
</li>
<li>Analysts who want to learn about the latest technology. 
</li>
<li>Laboratory leaders who want to leverage the full potential of their instrument.
</li>
</ul>
<blockquote>
Presenter: Matthew Gregory (Specialist, Sales Support, TEA &amp; DIA, UK &amp; Ireland, Thermo Fisher Scientific)
</blockquote>
<blockquote>
After graduating from the University of Surrey with an MChem in Chemistry, Matthew has gained 15 years experience of trace elemental analysis in industry, working in environmental and precious metal research laboratories. In 2018 Matthew joined Thermo Fisher Scientific as an Applications Specialist for the Trace Elemental Analysis product range in the UK and Ireland.
</blockquote>
<blockquote>
Presenter: Niel Williams (Specialist, Sales Support, TEA &amp; DIA, UK &amp; Ireland, Thermo Fisher Scientific)
</blockquote>
<blockquote>
After graduating in 2014, Niel first joined Teledyne Advanced Chemistry systems as an applications specialist and later technical sales specialist. In 2019, he took the role of applications specialist for the Trace Elemental Analysis product range in the UK and Ireland at Thermo Fisher Scientific. Niel holds a BSc in Geology and Planetary science and a PhD in Isotope Geochemistry from the University of Manchester.
</blockquote>
<blockquote>
Presenter: Simon Nelms (Product Marketing Manager TEA, Thermo Fisher Scientific)
</blockquote>
<blockquote>
Simon joined Thermo Fisher Scientific in 1996 as an applications specialist for ICP-MS, before taking a 2-year postdoctoral sabbatical at IRMM in Belgium. He re-joined the company in 2000 and in 2014 moved into Regional Marketing for the EMEA area. Simon has recently joined the Product Marketing team, covering trace elemental analysis accessories and software.
</blockquote>

Thermo Scientific: ICP-OES Educational Webinar

ICP-OES Educational Webinar

How to easily meet and surpass regulatory requirements for your trace elemental analysis.

Extracting the full potential of trace elemental analysis instrumentation to meet regulatory, compliance and performance requirements - Part 2 ICP-MS
Join this virtual demonstration of the Thermo Scientific™ iCAP™ RQ ICP-MS to learn how to easily meet and surpass regulatory requirements for your trace elemental analysis. In this online seminar we will focus on three key markets and demonstrate how the hardware and software of the iCAP RQ enhance performance and simplify your analysis.
The three markets covered are: 
Clinical research – Analyse difficult matrices with ease with enhanced system robustness and matrix tolerance. Advanced quality control features within the software simplify data validation. 
Environmental – Discover how the new ceramic PLUS torch enables improved performance and robustness. Find out about how to improve sample turnaround and validate large data sets quickly. 
Pharmaceutical – Learn how the tools in the Thermo Scientific Qtegra ISDS software enable full compliance with the requirements of regulatory frameworks such as the US FDA 21 CFR Part 11. 
This online seminar will conclude with a short panel discussion around the new regulations within each market and how the instrument hardware and software features future-proof your laboratory. 
Learning points:
<ul>
<li>Discover how the Thermo Scientific™ iCAP™ RQ hardware features provide you with class leading sensitivity, detection limits and stability. 
</li>
<li>Learn about how the latest software tools enable integration of this technology into your routine analysis and simplify compliance with your market regulations. 
</li>
<li>Find out how instruments from Thermo Fisher Scientific future-proof your lab, preparing you for stricter regulations with ever decreasing limits of detection, higher accuracy and better stability requirements.
</li>
</ul>
Who should attend? 
<ul>
<li>Laboratory managers and analysts who work with ICP-MS systems. 
</li>
<li>Analysts who want to learn about the latest technology. 
</li>
<li>Laboratory leaders who want to leverage the full potential of their instrument.
</li>
</ul>
<blockquote>
Presenter: Matthew Gregory (Specialist, Sales Support, TEA &amp; DIA, UK &amp; Ireland, Thermo Fisher Scientific)
</blockquote>
<blockquote>
After graduating from the University of Surrey with an MChem in Chemistry, Matthew has gained 15 years’ experience of trace elemental analysis in industry, working in environmental and precious metal research laboratories. In 2018 Matthew joined Thermo Fisher Scientific as an Applications Specialist for the Trace Elemental Analysis product range in the UK and Ireland.
</blockquote>
<blockquote>
Presenter: Niel Williams (Specialist, Sales Support, TEA &amp; DIA, UK &amp; Ireland, Thermo Fisher Scientific)
</blockquote>
<blockquote>
After graduating in 2014, Niel first joined Teledyne Advanced Chemistry systems as an applications specialist and later technical sales specialist. In 2019, he took the role of applications specialist for the Trace Elemental Analysis product range in the UK and Ireland at Thermo Fisher Scientific. Niel holds a BSc in Geology and Planetary science and a PhD in Isotope Geochemistry from the University of Manchester.
</blockquote>
<blockquote>
Presenter: Simon Nelms (Product Marketing Manager TEA, Thermo Fisher Scientific)
</blockquote>
<blockquote>
Simon joined Thermo Fisher Scientific in 1996 as an applications specialist for ICP-MS, before taking a 2-year postdoctoral sabbatical at IRMM in Belgium. He re-joined the company in 2000 and in 2014 moved into Regional Marketing for the EMEA area. Simon has recently joined the Product Marketing team, covering trace elemental analysis accessories and software.
</blockquote>

Thermo Scientific: ICP-MS Educational Webinar

ICP-MS Educational Webinar

Single Quadrupole Inductively Coupled Plasma Mass Spectrometers (ICP-MS) are a long-established tool for the analysis of trace elements in a variety of sample types.
With help of a collision cell, they can overcome most interferences and determine key contaminants across many application areas with low detection limits. This is why they are commonly found in laboratories analyzing all kinds of water samples, soils, foods and feed or industrial products. Over the last years, ICP-MS systems with triple quadrupole mass analyzers (TQ-ICP-MS), enabling advanced interference removal based on reactive gases such as oxygen or ammonia, have increasingly found their way from research driven applications into applied analytical sciences, but are still not found in large number of laboratories providing service testing at a large scale. This is despite their proven track record of providing superior interference removal, improving right results first time, and increasing confidence in &quot;right first time&quot; results. The underlying reasons are mainly because of the higher initial investment not only in the instrument as such, but also in additional laboratory infrastructure, such as providing additional gases like ammonia to the lab.
Key learning objectives
<ul>
<li>Understand the differences in hardware and how they translate into better interference removal and superior detection limits
</li>
<li>See how triple quadrupole ICP-MS can help you to overcome challenges in sample type, independent of the matrix.
</li>
<li>Understand what is needed in order to leverage the full potential of a triple quadrupole ICP-MS.
</li>
<li>Learn how triple quadrupole ICP-MS can help you to improve lab efficiency and realize time savings
</li>
</ul>
<blockquote>
Presenter: Dr. Daniel Kutscher (Product Marketing Specialist, Thermo Fisher Scientific)
</blockquote>
<blockquote>
Presenter: Dr. Magda Mandic (ICP-MS Product Manager, Thermo Fisher Scientific)
</blockquote>

Thermo Scientific: Understanding the Benefits of Triple Quadrupole ICP-MS in Everyday Analysis

Understanding the Benefits of Triple Quadrupole ICP-MS in Everyday Analysis

Understand the differences in hardware and how they translate into better interference removal and superior detection limits.

Understanding the Benefits of Triple Quadrupole ICP-MS

<h3>Building a strong foundation for your analytical workflow</h3>
Your results are only as accurate as your reference. Within Pharma QC, whether you are performing dissolution testing or releasing finished goods, having accurate, reliable and fully characterized Reference Materials is critical. This webinar will provide viewers with an overview of key concepts relating to Reference Materials.
With a multitude of suppliers serving the industry – both compendial and commercial – there are myriad choices of Reference Materials available for a quality control laboratory. We will discuss how different quality grades are “fit for purpose,” best practices in Reference Material production, and what to look for in a Reference Material Certificate of Analysis.
We will also discuss a novel concept: fully characterized Certified Reference Materials (CRMs) qualified against compendial standards. These CRMs are designed to replace a laboratories in-house working standards and pair with a laboratory’s primary Reference Standards to form a strong, well-characterized and fully traceable Reference Material foundation.
<h3>Key Learning Objectives</h3>
<ul>
<li>Understand how different Reference Material quality grades are fit-to-purpose</li>
<li>Provide key concepts in Reference Material manufacture and characterization</li>
<li>Detail Certificate of Analysis (CoA) key attributes that will be common across sources</li>
</ul>
<h3>Audience</h3>
<ul>
<li>Laboratory Directors</li>
<li>Pharmaceutical Quality Control (QC) Managers</li>
<li>Pharmaceutical Quality Control (QC) technicians</li>
</ul>
<blockquote>
Presenter: Michael Hurst (Product Manager - Reference Materials)
</blockquote>

ICPMS webinars focusing on Academy/Principles - page 10