Build up your protein formulation toolbox with Uncle

In the world of protein formulations, just one poorly behaved excipient can ruin your day… and your dataset. The wrong excipient can promote unfolding or aggregation, so having a big toolbox handy to test how a formulation behaves can save the day. Uncle’s unique combination of fluorescence, SLS, DLS and wide variety of applications means the right tool for the job is always handy – thermal stability, isothermal experiments, kD & B22, G22 and more. Uncle even has a tool for those unruly excipients that throw a wrench in your data by interfering with your protein’s intrinsic fluorescence. Uncle’s full-spectrum fluorescence detection sees fluorescence issues, lets you diagnose what’s going on and helps you solve the problem by changing up your analysis. 

This talk will look at the many tools Uncle can use to screen formulations for their impact on protein stability, and how Uncle helps you keep an eye out for any nasty surprises that oddball excipients can throw your way.

Presenter: Andre Mueller, PhD (Marketing Manager, Biologic Solutions, Unchained Labs)

Andre Mueller, PhD, is the Product Manager for Aunty and Honeybun at Unchained Labs, where he supports the development of biologic and gene therapy drugs. He specializes in fluorescence, static and dynamic light scattering, focusing on biophysical characterization of proteins and viral vectors. His research background spans from structural biology to plant physiology, with experience in labs across Germany, Sweden, Denmark, and the USA. Andre earned his PhD at the Carlsberg Laboratory and completed a postdoctoral fellowship at Stanford University.

Moderator: Kevin Lance, PhD (Marketing Manager, Analytical Instruments, Unchained Labs)