<div><div>Researchers led by <a target="_blank" rel="noopener noreferrer" href="https://kudova.group.uochb.cz/en">Eva Kudová</a> from IOCB Prague and Jitka Viktorová from UCT Prague have identified new androstane-based steroid derivatives that can significantly improve the effectiveness of existing antibiotics against multidrug-resistant Staphylococcus aureus.</div></div><div>The team screened dozens of natural steroidal hormones and synthetic derivatives to see whether they could block bacterial efflux pumps – mechanisms that bacteria use to eject antibiotics and survive treatment. Two compounds emerged as particularly promising: they inhibited efflux pumps and lowered the effective doses of antibiotics such as ciprofloxacin and erythromycin.Further analysis showed that one of the compounds also suppressed genes linked to bacterial virulence. Another key finding is that the most active molecules are non-toxic to human immune cells and showed no detectable endocrine activity, suggesting a favorable safety profile.These findings support the idea that rationally designed steroid-based molecules could act as antibiotic adjuvants, helping existing drugs overcome bacterial resistance.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/IOCB_Prague_Steroidal_hormones_and_neurosteroids_novel_therapeutic_strategies_in_bacterial_infections_8e5d2a7b48.jpg" alt="IOCB Prague: Steroidal hormones and neurosteroids – novel therapeutic strategies in bacterial infections" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_IOCB_Prague_Steroidal_hormones_and_neurosteroids_novel_therapeutic_strategies_in_bacterial_infections_8e5d2a7b48.jpg 222w," sizes="100vw" width="1258" height="886"><blockquote><h4>Original Article</h4><h4><a target="_blank" rel="noopener noreferrer" href="https://www.sciencedirect.com/science/article/pii/S0223523426001613?via%3Dihub">Steroidal hormones and neurosteroids - novel therapeutic strategies in bacterial infections: Design, synthesis, and biological evaluation</a></h4>Daniela Brdová, Bára Křížkovská, Jan Špaček, Zdeněk Míchal, Eva Jablonská, Ondřej Strnad, Hana Chodounská, Eszter Szánti-Pintér, Marina Morozovová, Václav Hanžl, Jan Tkadlec, Martijn Riool, Jan Lipov, Jitka Viktorová, Eva Kudová&nbsp;Eur. J. Med. Chem., 2026, 308, 118716<a target="_blank" rel="noopener noreferrer" href="https://doi.org/10.1016/j.ejmech.2026.118716">https://doi.org/10.1016/j.ejmech.2026.118716</a><h6>licensed under <a target="_blank" rel="noopener noreferrer" href="https://creativecommons.org/licenses/by/4.0/">CC-BY 4.0</a></h6></blockquote><h4>Abstract</h4>The global rise of antibiotic resistance necessitates novel therapeutic strategies for infectious diseases. Inhibition of bacterial efflux pumps, which contribute to multidrug resistance, represents a promising approach to restore or even increase the efficacy of existing antibiotics. Using fluorescence-based ethidium bromide accumulation, broth microdilution, and checkerboard assays, we evaluated 26 endogenous steroidal hormones and neurosteroids, along with 30 synthetic derivatives, for their ability to enhance antibiotic susceptibility in multidrug-resistant Staphylococcus aureus. Structure-activity relationship analysis identified compounds 13 and 16 as lead candidates, exhibiting strong efflux pump inhibition and marked reductions in the minimum inhibitory concentrations of ciprofloxacin and erythromycin. Both compounds showed additive effects in checkerboard assays. Modifications at C-3 (polar substitution) and C-17 (3α,5β-stereochemistry and nonpolar substitution) were essential for potent efflux inhibition and sensitization, although these modifications were not additive when combined. Transcriptome analysis further revealed that compound 13 significantly downregulated S. aureus virulence-associated genes when administered alone or in combination with antibiotics. Cytotoxicity assessment in human peripheral blood mononuclear cells and receptor transactivation assays for estrogen, androgen, and progesterone receptors indicated that the most active derivatives were non-toxic and lacked detectable endocrine activity, suggesting a favorable safety profile. Overall, these findings support the concept that rationally designed andostane-based steroidal scaffolds can function as competitive bacterial efflux pump inhibitors and serve as potential antibiotic adjuvants to mitigate efflux-mediated resistance.<h4>Instrumentation</h4><h5>Structural characterization</h5><ul><li>AVANCE III 400 MHz NMR spectrometer (Bruker)</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/library?mainauthorItems=3&amp;search=LTQ+Orbitrap+XL">LTQ Orbitrap XL HRMS</a> (Thermo Fisher Scientific, ESI)</li></ul></div>

Steroidal hormones and neurosteroids – novel therapeutic strategies in bacterial infections

Wiley, a global leader in authoritative content and research intelligence for the advancement of scientific discovery, innovation and learning, today announced the release of additional data to its IR and Raman spectral libraries, significantly broadening compound coverage, including materials, polymers, minerals, and others.This latest release includes the first installment of Raman spectra from Wiley's collaboration with the American Museum of Natural History (AMNH), announced earlier this spring, drawing from one of the world's most important mineral collections.“Researchers depend on reference data as a foundation for sound scientific decisions,” said Graeme Whitley, senior director, data science solutions at Wiley. “Continuous updates ensure scientists always have the most current, reliable reference libraries at their fingertips, helping them work faster and make confident decisions when it matters most.”<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Wiley_Wiley_expands_its_trusted_IR_and_Raman_spectral_library_collections_helping_analytical_labs_make_faster_more_confident_decisions_1a54aaad3a.jpg" alt="Wiley: Wiley expands its trusted IR and Raman spectral library collections—helping analytical labs make faster, more confident decisions" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Wiley_Wiley_expands_its_trusted_IR_and_Raman_spectral_library_collections_helping_analytical_labs_make_faster_more_confident_decisions_1a54aaad3a.jpg 245w," sizes="100vw" width="1600" height="856"><h4>Summary of updates:</h4><h5>KnowItAll Raman Spectral Library Collection</h5><ul><li>Added: 1,213 spectra</li><li>Now contains: 29K+ spectra</li></ul>2 new databases:<ul><li>Raman – American Museum of Natural History Minerals – Wiley – 198 spectra</li><li>Raman – Microbiology – 71 spectra</li></ul>Spectra added to databases:<ul><li>Raman – Consumer Goods &amp; Food-Related Compounds – +104</li><li>Raman – Drugs – +128</li><li>Raman – Materials – +132</li><li>Raman – Minerals – +233</li><li>Raman – Polymers – +5</li><li>Raman – Pigments &amp; Dyes – +342</li></ul><h5>KnowItAll IR Spectral Library Collection</h5><ul><li>Added: 949 spectra</li><li>Now contains: 344K+ spectra</li></ul>7 new databases:<ul><li>ATR-IR – Clinical – 364 spectra</li><li>ATR-IR – Materials – 10 spectra</li><li>ATR-IR – Pigments &amp; Dyes – 420 spectra</li><li>ATR-IR – Polymers – 21 spectra</li><li>IR – Clinical – 20 spectra</li><li>IR – Materials – 17 spectra</li><li>IR – Microbiology – 75 spectra</li></ul>Spectra added to databases:<ul><li>IR – Minerals – +5</li><li>IR – Polymers – +17</li></ul>Spectral library subscribers automatically gain access to new data, ensuring labs always have the most current, reliable reference libraries to improve analysis, reduce errors, and increase productivity.<ul><li>Learn more at: <a target="_blank" rel="noopener noreferrer" href="https://sciencesolutions.wiley.com/spectral-databases/">www.sciencesolutions.wiley.com/spectral-databases</a></li><li>Existing subscribers can access step-by-step guidance on updating their KnowItAll databases at <a target="_blank" rel="noopener noreferrer" href="https://sciencesolutions.wiley.com/how-to-update-knowitall-databases">https://sciencesolutions.wiley.com/how-to-update-knowitall-databases</a></li></ul><h5>Wiley Spectral Databases</h5>Wiley's spectral databases are consistently evolving to meet today's research demands, covering multiple spectral techniques across a wide range of applications including polymers, materials, environmental, forensics, toxicology, pharmaceutical, biotech, automotive, aerospace, food, cosmetics, and more. Built on rigorous quality protocols, Wiley delivers industry-leading spectral data and intelligent tools to accelerate analysis and deliver deeper insights — making it the authoritative, trusted source that analytical labs worldwide rely on.&nbsp;<h5>About Wiley</h5>Wiley (NYSE: WLY) is a global leader in authoritative content and research intelligence for the advancement of scientific discovery, innovation, and learning. With more than 200 years at the center of the scholarly ecosystem, Wiley combines trusted publishing heritage with AI-powered platforms to transform how knowledge is discovered, accessed, and applied. From individual researchers and students to Fortune 500 R&amp;D teams, Wiley enables the transformation of scientific breakthroughs into real-world impact. From knowledge to impact—Wiley is redefining what's possible in science and learning.&nbsp;

Wiley expands its trusted IR and Raman spectral library collections

Our Library never stops expanding. What are the most recent contributions to LabRulezICPMS Library in the week of 4th May 2026? Check out new documents from the field of spectroscopy/spectrometry and related techniques!<blockquote>👉 <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/library">SEARCH THE LARGEST REPOSITORY OF DOCUMENTS ABOUT SPECTROSCOPY/SPECTROMETRY RELATED TECHNIQUES</a></blockquote><blockquote>👉 Need info about different analytical techniques? Peek into <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/library">LabRulezLCMS</a> or <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library">LabRulezGCMS</a> libraries.</blockquote>This week we bring you application notes by KNAUER, Shimadzu, and Thermo Fisher Scientific!<h3>1. KNAUER: Analysis of HPLC fractions by Benchtop NMR</h3><ul><li>Application note</li><li><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/labrulez-bucket-strapi-h3hsga3/knauer_hplc_benchtop_nmr_web_638c60e13c.pdf">Full PDF for download</a></li></ul>Preparative HPLC is essential for isolating compounds and removing impurities in pharmaceutical and chemical industries. Non-destructive, fast analysis is preferred to maintain yield and enable at-line monitoring, avoiding lengthy sample preparation. Recent advancements in benchtop NMR spectrometers (up to 90 MHz) allow quick analysis without deuterated solvents. In this proof-of-concept study we purified a pharmaceutical sample via HPLC and confirmed its identity using benchtop NMR. Fractions (0.7–4.4 mM) were analyzed without preparation, using only 300 µL per sample, ensuring rapid batch control with no product loss. This study demonstrates the seamless integration of HPLC and benchtop NMR.<h4>Experimental</h4><h5>Preparative HPLC Method</h5>Eluent 20:80 Ethanol/water, isocratic mode, flow rate 12.5 ml/min, detection UV254 nm 2 Hz, 500 µl stacked injection, automated fractionation with threshold function, column temperature ambient, Column Eurospher II 100-10 C18 150x20 mm&nbsp;<h5>Analytical HPLC Method</h5>Eluent 20:80 Ethanol /water + 0.1% formic acid, isocratic mode, flow rate 1 ml/min, detection UV254 nm 10 Hz, 5 µl partial loop injection, column temperature 25 °C, Column <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/1633">Eurospher II 100-5 C18</a> 150x4 mm&nbsp;<h5>NMR Method&nbsp;</h5>NMR spectra were acquired on a Magritek Multi-X Ultra 80 MHz benchtop NMR system using an adapted WET sequence for solvent suppression. 32 scans were acquired with a repetition time of 15s. WET parameters were adjusted for each sample to yield optimal suppression for all solvent signals. Pooled HPLC fractions were analysed directly without addition of deuterated solvents or other sample preparation.<h4>Conclusion</h4>This proof-of-concept study successfully shows that HPLC and benchtop NMR can be used together easily. Samples can be analyzed non-destructively within minutes and without any further preparation due to highly efficient suppression of multiple solvent signals. Compounds can be identified without the need of reference standards. This study shows that NMR can provide a valid compatible alternative detector for HPLC fraction analysis.<h3>2. Shimadzu: DIC Analysis in High-Speed Tensile Test of CFRP</h3><ul><li>Application note</li><li><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/labrulez-bucket-strapi-h3hsga3/an_01_00854_en_fb6c68b858.pdf">Full PDF for download</a></li></ul><h4>User Benefits</h4><ul><li>The <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/library?mainauthorItems=1&amp;search=HPV-X3">HPV-X3</a> is suitable for observation of fracture of brittle materials such as CFRP because it has a maximum recording speed (framerate) of 20 Mfps.&nbsp;</li><li>The HPV-X3 provides improved DIC analysis performance, as its resolution is 3 times higher than that of the conventional highspeed video camera.</li><li>The HITS-TX impact testing machine enables testing at a maximum speed of 20 m/s</li></ul>Carbon fiber reinforced plastic (CFRP) is a material with particularly high specific strength, even among composite materials, and used in various applications such as transport aircraft, taking advantage of its excellent mechanical properties. Because CFRP consists of carbon fibers and resin, it shows complex fracture behavior, and brittle fracture progresses from damage as the point of origin. Since fracture proceeds instantaneously, a high-speed video camera with a high recording speed is necessary when observing fracture of CFRP. One method for measuring strain in a high-speed tensile test is Digital Image Correlation (DIC), which visualizes the distribution of strain at the specimen surface by comparing a random pattern on the specimen surface before and after deformation. Thus, a high-speed video camera with a high resolution is also necessary in order to improve the DIC performance.&nbsp;Newly-developed <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/library?mainauthorItems=1&amp;search=HPV-X3">Hyper Vision HPV-X3 high-speed video camera</a> is extremely well-suited to DIC analysis of CFRP, as its recording speed is 2 timesfaster and itsresolution is 3 times higher than the conventional HPV-X2. In this experiment, a high-speed tensile test of CFRP was conducted using a HITS-TX high-speed tensile testing machine. The condition of the test was observed with the new HPV-X3, and the strain distribution of the CFRP test piece was clarified by a DIC analysis of the recorded images.<h4>Test Piece and Test Instruments</h4>A CFRP quasi-isotropic laminate was used as the test piece. Aluminum foil was glued to the back side of the test piece, and the timing when the electrical conduction of the aluminum foil was interrupted by fracture of the test piece was used as the trigger for video recording. The HITS-TX was used in the highspeed tensile test. The HPV-X3 was used in fracture observation, and for comparison, the fracture process was also recorded with the conventional HPV-X2 camera. Fig. 1 shows the condition of the test, and Table 1 and Table 2 show the equipment composition and test conditions, respectively.<h4>DIC Analysis Results in High-Speed Tensile Test</h4>Fig. 3 shows the DIC analysis results in the high-speed tensile test. The color bar was set to display the color purple at around 0 % strain and red at around 2 % strain. Fig. 3 (1) is an image at the start of the test. After the test started, strain in the 45˚ direction concentrated from the lower left to the right central area, as can be seen in Fig. 3 (2). Then, as the test progressed, a condition of increasing strain in the initial area of strain concentration can be seen in Fig. 3 (3) to (9). A crack occurs in Fig. 3 (10), and strain decreases in the crack area. Following this, the test piece fractured completely in Fig. 3 (11) and (12), and a decrease in the strain in the area around the crack could be observed.<h4>Conclusion</h4>A high-speed tensile test of CFRP was conducted using a HITSTX high-speed tensile testing machine and the newlydeveloped HPV-X3 high-speed video camera, and the strain distribution at the time of test piece fracture was visualized by a DIC analysis. Because the HPV-X3 offers a 3 times higher resolution and a 2 times faster recording speed than the conventional device, it is a suitable high-speed video camera for fracture observation and DIC analysis in impact tests of brittle materials such as CFRP. The measurement system introduced in this Application News article is a useful tool for the development of composite materials.<h3>3. Thermo Fisher Scientific: Polymer analysis using femtosecond-laser-ablation depth profiling</h3><ul><li>Application note</li><li><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/labrulez-bucket-strapi-h3hsga3/xps_depth_profiling_polymer_analysis_appnote_c731e2e7e0.pdf">Full PDF for download</a></li></ul>X-ray photoelectron spectroscopy (XPS) is an essential polymer characterization technique that can identify not just the elemental composition but also the chemical state of polymer samples. This allows the chemical bonding environment to be deduced and, as a result, the polymer species can be identified. This can all be achieved with minimal sample preparation thanks to the built-in charge-compensation systems found in XPS instruments, which simplify the analysis of insulating samples.&nbsp;The introduction of gas cluster ion sources (GCIS), such as the Thermo Scientific™ MAGCIS Dual Mode Ion Source, marked a major step forward in polymer analysis. Unlike monatomic ion beams, GCIS are able to clean surface contamination, and etch away layers of sample material, without damaging the underlying chemistry of organic samples such as polymers. As a result, GCIS has allowed chemical-damage-free analysis to reach micrometers below the sample surface. This depth of analysis can be highly time consuming, however, and total experimental times can range from multiple hours to days.&nbsp;The addition of femtosecond-laser-ablation (fs-LA) technology is alleviating this, allowing for XPS spectra to be collected from a depth of tens of µm into a sample in a matter of minutes. This is because the laser ablation occurs on the femtosecond timescale (i.e., nearly instantaneously), effectively eliminating the material removal time of the depth profile. Additionally, unlike other material removal techniques such as atomic ion beam impact (where a collision cascade effect is induced to remove surface material) fs-LA is capable of removing material without chemical damage due to the ultrashort columbic explosion process used to eject the material. The resulting profile is therefore representative of the actual sample chemistry.<h4>Paint layer analysis&nbsp;</h4>In traditional ion-beam depth profiling, analytical depths are generally limited to several hundred nanometers, up to a micrometer. This means that it is extremely difficult to analyze the interfaces between multiple micrometer-thick layers in a sample without the use of additional techniques such as ultralow-angle microtome (ULAM) sectioning.¹ The introduction of fs-LA technology, however, allows micrometers of material to be removed rapidly, enabling the characterization of layered samples.&nbsp;As an example, a multi-layer paint specimen (provided by the University of Surrey, UK) was depth profiled using the <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/products/2206">Thermo Scientific™ Hypulse™ Surface Analysis System</a>. The sample consists of an aluminum substrate coated with a 5 µm layer of polyurethane primer followed by a 25 µm PMMA/PVdF topcoat.The depth profile was generated using a 1,030 nm laser with an energy of 250 µJ for ablation, along with a 30 µm X-ray spot size for data collection. XPS spectra were collected after each ablation cycle to obtain an atomic concentration plot through both paint layers into the substrate material (Figure 2).&nbsp;5 distinct regions throughout the analyzed depth can be seen. The top surface of the sample consists of an adventitious layer of carbon contamination, which is commonly found on samples exposed to air. The second layer is the 25 µm PVdF/PMMA topcoat, and the third layer is the PU primer. Between the primer and the final aluminum substrate layer, a clear increase in adventitious carbon is observed, similar to the signal seen at the top sample surface. This suggests residual carbon contamination was present on the substrate before the paint layers were applied.&nbsp;It would take hours to produce the XPS depth profile shown in Figure 2 using traditional ion beam approaches. Even with the use of a monatomic beam with a high energy per atom, the length of the analysis could still be just as long, depending on the sample material, and would sacrifice the chemistry of any organic/polymeric materials. The combination of fs-LA depth profiling and snapshot XPS acquisition, meanwhile, can reduce the experimental time to less than 20 minutes without inducing any chemical damage to the sample surface.<h4>Summary&nbsp;</h4>One of the most critical aspects of successful polymer XPS depth profiling is the preservation of the sample chemistry during material removal. Additionally, experiment time can be a significant limiting factor, and thicker samples could lead to reduced time for repeat experiments. The femtosecond laser ablation capabilities of the Hypulse Surface Analysis System provide fast, efficient, and chemical-damage-free material removal from a sample surface, enabling analysis multiple micrometers into a sample. This means that hidden sample interfaces, that were largely inaccessible before, can now be analyzed easily and efficiently

News from LabRulezICPMS Library - Week 19, 2026

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The Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences (IOCB Prague) is a leading scientific institution in the Czech Republic, recognized internationally. Its primary mission is basic research in the fields of chemical biology and medicinal chemistry, organic and material oriented chemistry, chemistry of natural compounds, biochemistry and molecular biology, physical chemistry, theoretical chemistry, and analytical chemistry. 

Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences

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Thermo Scientific iCAP™ PRO ICP-OES Radial

The Thermo Scientific™ iCAP™ PRO ICP-OES delivers robust trace elemental analysis with easy-to-use software and pre-optimized methods, offering superior multi-element detection over single-element AAS.

Deliver robust, uncomplicated trace elemental analysis with the Thermo Scientific™ iCAP™ PRO ICP-OES system. This system offers easy-to-use software with pre-optimized method conditions, providing multi-element detection technology far superior to that of single-element AAS.This compact, benchtop ICP-OES provides simultaneous analysis of trace elements in a range of samples. The vertical torch orientation system delivers excellent robustness for both radial and dual view instruments with a corrosion-resistant inner torch box. The purged echelle polychromator and Charge Injection Device (CID) array detector provide high light throughput, resulting in excellent detection limits.<h3>The system includes</h3><ul><li>A 3-channel, peristaltic pump for easy addition of an online internal standard or use of a hydride generation accessory.</li><li>A quick-release semi-demountable torch for easy maintenance.</li><li>A solid-state, free-running 27.12 MHz RF generator to ensure robust plasma generation for any sample matrix.</li><li>Three independent mass flow controllers (MFC) for precision control of the nebulizer, plasma, and auxiliary gas and to ensure long-term stability.</li><li>An interlock drain sensor to shut down the system if a leak in the sample path is detected and to prevent samples being lost.</li><li>An echelle polychromator that is thermostatically controlled to ensure long-term stability and reduce the need for recalibration.</li><li>A cross-dispersing prism combined with an echelle to provide a resolution of 7 pm and minimize interferences.</li><li>A random-access CID imager provides full wavelength coverage from 167.021 to 852.145 nm.</li><li><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/products/1489">Thermo Scientific™ Qtegra™ Intelligent Scientific Data Solution™</a> (ISDS) Software, providing an easy-to-navigate platform that allows the analyst to add wavelengths, create methods, analyze samples and post-process the data while the spectrometer is acquiring data.</li></ul><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Pragolab_Thermo_Scientific_Spektrometr_ICP_OES_i_CAP_PRO_Cover_5678c2a10f.jpg" alt="Thermo Scientific iCAP™ PRO ICP-OES Radial" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Pragolab_Thermo_Scientific_Spektrometr_ICP_OES_i_CAP_PRO_Cover_5678c2a10f.jpg 197w," sizes="100vw" width="1000" height="792"><h3>Specifications</h3><ul><li>Type: ICP-OES Radial</li><li>Auxiliary Gas: MFC stabilized at 0.5 LPM</li><li>Detector Type: High performance solid-state CID821</li><li>Nebulizer Gas: MFC tunable, 0.3 to 0.8 LPM</li><li>Peristaltic Pump: 3-channel, 0 or 45 rpm</li><li>Plasma Gas: MFC stabilized at 12.5 LPM</li><li>Plasma Viewing: Vertical Radial, optimized at 11 mm</li><li>RF Source: 27 MHz, optimized at 1150 W</li><li>Description: iCAP PRO ICP-OES Radial</li><li>Dimensions (D x W x H): 690 x 615 x 933 mm</li><li>Purge: 3.4 LPM</li><li>Spectral Bandpass: 7 pm at 200 nm</li><li>Spectrometer: Simultaneous echelle</li><li>Standard Sampling Kit: Concentric glass nebulizer, Glass cyclonic spray chamber, Semi-demountable EMT torch, 2 mm bore quartz center tube</li><li>Warm Up Time: 1 hr. from off</li><li>Wavelength Range: 167 to 852 nm</li><li>Unit Size: Each</li></ul><h4>iCAP PRO Series ICP-OES has ACT label certification</h4>Reduce your lab's environmental impact with the iCAP PRO Series ICP-OES, recipient of the ACT label from My Green Lab. The ACT Environmental Impact Factor Label is the world's premier eco-label for laboratory products. The program ensures Accountability, Consistency, and Transparency in the reporting of environmental impact data to enable sustainable laboratory procurement. It was designed by both scientists and procurement specialists to provide clear, third-party verified information about the sustainability profile of laboratory products. By providing needed transparency around manufacturing, energy and water use, packaging, and end-of-life impacts, ACT makes it easy to choose environmentally preferable products and reduce the carbon impact of laboratory supply chains.

Thermo Scientific iCAP™ PRO X ICP-OES Radial

The Thermo Scientific™ iCAP™ PRO X ICP-OES delivers robust trace elemental analysis with easy-to-use software and pre-optimized methods, offering superior multi-element detection over single-element AAS.

Deliver robust, uncomplicated trace elemental analysis with the Thermo Scientific™ iCAP™ PRO X ICP-OES system. This system offers easy-to-use software with pre-optimized method conditions, providing multi-element detection technology far superior to that of single-element AAS.This compact, benchtop ICP-OES provides simultaneous analysis of trace elements in a range of samples. The vertical torch orientation system delivers excellent robustness for both radial and dual view instruments with a corrosion-resistant inner torch box. The purged echelle polychromator and Charge Injection Device (CID) array detector provide high light throughput, resulting in excellent detection limits.<h3>The system includes</h3><ul><li>A 3-channel, peristaltic pump for easy addition of an online internal standard or use of a hydride generation accessory.</li><li>A quick-release semi-demountable torch for easy maintenance.</li><li>A solid-state, free-running 27.12 MHz RF generator to ensure robust plasma generation for any sample matrix.</li><li>Three independent mass flow controllers (MFC) for precision control of the nebulizer, plasma, and auxiliary gas and to ensure long-term stability.</li><li>An interlock drain sensor to shut down the system if a leak in the sample path is detected and to prevent samples being lost.</li><li>An echelle polychromator that is thermostatically controlled to ensure long-term stability and reduce the need for recalibration.</li><li>A cross-dispersing prism combined with an echelle to provide a resolution of 7 pm and minimize interferences.</li><li>A random-access CID imager provides full wavelength coverage from 167.021 to 852.145 nm.</li><li><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/products/1489">Thermo Scientific™ Qtegra™ Intelligent Scientific Data Solution™</a> (ISDS) Software, providing an easy-to-navigate platform that allows the analyst to add wavelengths, create methods, analyze samples and post-process the data while the spectrometer is acquiring data.</li></ul><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Pragolab_Thermo_Scientific_Spektrometr_ICP_OES_i_CAP_PRO_X_718dec6a47.jpg" alt="Thermo Scientific iCAP™ PRO X ICP-OES Radial" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Pragolab_Thermo_Scientific_Spektrometr_ICP_OES_i_CAP_PRO_X_718dec6a47.jpg 197w," sizes="100vw" width="800" height="634"><h3>Specifications</h3><ul><li data-start="25" data-end="53">Type: ICP-OES Radial</li><li data-start="54" data-end="102">Auxiliary Gas: MFC stabilized at 0.5 LPM</li><li data-start="103" data-end="161">Detector Type: High performance solid-state CID821</li><li data-start="162" data-end="212">Nebulizer Gas: MFC tunable, 0.3 to 0.8 LPM</li><li data-start="213" data-end="261">Peristaltic Pump: 3-channel, 0 or 45 rpm</li><li data-start="262" data-end="308">Plasma Gas: MFC stabilized at 12.5 LPM</li><li data-start="309" data-end="348">Plasma Viewing: Vertical Radial</li><li data-start="349" data-end="374">RF Source: 27 MHz</li><li data-start="375" data-end="421">Description: iCAP PRO X ICP-OES Radial</li><li data-start="422" data-end="472">Dimensions (D x W x H): 690 x 615 x 933 mm</li><li data-start="473" data-end="495">Purge: 3.4 LPM</li><li data-start="496" data-end="537">Spectral Bandpass: 7 pm at 200 nm</li><li data-start="538" data-end="580">Spectrometer: Simultaneous echelle</li><li data-start="581" data-end="726">Standard Sampling Kit: Concentric glass nebulizer, Glass cyclonic spray chamber, Semi-demountable EMT torch, 2 mm bore quartz center tube</li><li data-start="727" data-end="787">Warm Up Time: 30 min. from off, 15 min. from standby</li><li data-start="788" data-end="827">Wavelength Range: 167 to 852 nm</li><li data-start="828" data-end="851" data-is-last-node="">Unit Size: Each</li></ul><h4>iCAP PRO Series ICP-OES has ACT label certification</h4>Reduce your lab's environmental impact with the iCAP PRO Series ICP-OES, recipient of the ACT label from My Green Lab. The ACT Environmental Impact Factor Label is the world's premier eco-label for laboratory products. The program ensures Accountability, Consistency, and Transparency in the reporting of environmental impact data to enable sustainable laboratory procurement. It was designed by both scientists and procurement specialists to provide clear, third-party verified information about the sustainability profile of laboratory products. By providing needed transparency around manufacturing, energy and water use, packaging, and end-of-life impacts, ACT makes it easy to choose environmentally preferable products and reduce the carbon impact of laboratory supply chains.

Thermo Scientific iCAP PRO XP ICP-OES

Analyze high-matrix trace elemental samples with sensitive multi-element detection and meet your data requirements with the optimal performance of the Thermo Scientific™ iCAP™ PRO XP ICP-OES. 

Analyze high-matrix trace elemental samples with sensitive multi-element detection and meet your data requirements with the optimal performance of the Thermo Scientific™ iCAP™ PRO XP ICP-OES. Rugged on all fronts, this system needs surprisingly little bench space or user maintenance.A bench top simultaneous ICP spectrometer with a vertical torch, a purged echelle polychromator and Charge Injection Device (CID) array detector. It includes:<ul><li>a 4-channel, peristaltic pump to allow for the use of an advance accessories.</li><li>a solid-state, free-running 27.12 MHz RF generator to ensure robust plasma generation for any sample matrix.</li><li>three independent MFCs to precisely control the nebulizer, plasma, and auxiliary gas and to ensure long-term stability.</li><li>the option to add an additional gas to the plasma via an integrated MFC with a flow of 0-0.25 L/min. This enables analysis of high-salt samples (up to 30% TDS) or organics.</li><li>an interlock drain sensor to shut down the system if a leak in the sample path is detected and to prevent samples from being lost.</li><li>an echelle polychromator that is thermostatically controlled to ensure long-term stability and reduce the need for recalibration.</li><li>a cross-dispersing prism combined with an echelle to provide a resolution of 7 pm and minimize interferences.</li><li>a random-access CID imager that provides full wavelength coverage from 167.021 to 852.145 nm.</li><li>an enhanced UV mode to allow better sensitivity and detection limits for elements between 167.021 and 240.063 nm via a second UV focused exposure.</li><li>Thermo Scientific™ <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/products/1489">Qtegra™ Intelligent Scientific Data Solution™ (ISDS) Software</a>, providing an easy-to-navigate platform that allows the analyst to add wavelengths, create methods, analyze samples and post-process the data while the spectrometer is acquiring data.</li></ul><h4>iCAP PRO Series ICP-OES has ACT label certification</h4>Reduce your lab's environmental impact with the iCAP PRO Series ICP-OES, recipient of the ACT label from My Green Lab. The ACT Environmental Impact Factor Label is the world's premier eco-label for laboratory products. The program ensures Accountability, Consistency, and Transparency in the reporting of environmental impact data to enable sustainable laboratory procurement. It was designed by both scientists and procurement specialists to provide clear, third-party verified information about the sustainability profile of laboratory products. By providing needed transparency around manufacturing, energy and water use, packaging, and end-of-life impacts, ACT makes it easy to choose environmentally preferable products and reduce the carbon impact of laboratory supply chains.<h4>Key specifications</h4>Instrument Type: ICP-OES (Inductively Coupled Plasma Optical Emission Spectrometer) Model: iCAP PRO XP ICP-OES Duo Viewing Configuration: Duo (axial and radial plasma viewing) Spectrometer: Simultaneous echelle Spectral Bandpass: 7 pm at 200 nm Wavelength Range: 167–852 nm RF Source: 27 MHz, adjustable from 750 to 1600 W Detector Type: CID821 Torch Orientation: Vertical Radial Viewing Height: 6–18 mm<h5>Sample Introduction System</h5><ul><li>Peristaltic Pump: 4-channel, adjustable 0–125 rpm</li><li>Standard Sampling Kit Includes:<ul><li>Concentric glass nebulizer</li><li>Glass cyclonic spray chamber</li><li>EMT Duo torch</li><li>2 mm bore quartz center tube</li></ul></li></ul><h5>Gas Flow Control (MFC Tunable)</h5><ul><li>Plasma Gas Flow: 0.0–20.0 L/min</li><li>Nebulizer Gas Flow: 0.0–1.5 L/min</li><li>Auxiliary Gas Flow: 0.0–2.0 L/min</li><li>Purge Gas Flow: 3.4 L/min</li></ul><h5>General Specifications</h5><ul><li>Warm-Up Time: 5 minutes from standby</li><li>Dimensions (D × W × H): 690 × 615 × 933 mm</li><li>Unit Size: Each</li></ul>

Thermo Scientific iCAP PRO XPS ICP-OES (optical emission spectrometer)

Experience high-speed analysis of your trace elemental samples with the Thermo Scientific™ iCAP™ PRO XPS ICP-OES. It meets your specific regulatory requirements with unmatched throughput and versatility.

Experience high-speed analysis of your trace elemental samples with the Thermo Scientific™ iCAP™ PRO XPS ICP-OES. It meets your specific regulatory requirements with unmatched throughput and versatility.A benchtop simultaneous ICP spectrometer with a vertical torch, purged echelle polychromator and Charge Injection Device (CID) array detector.&nbsp;<h5>The standard configuration includes:</h5><ul><li>a 4-channel, peristaltic pump to allow for the use of advanced accessories.</li><li>a solid-state, free-running 27.12 MHz RF generator to ensure robust plasma generation for any sample matrix.</li><li>three independent MFCs to precisely control the nebulizer, plasma, and auxiliary gas and to ensure long-term stability.</li><li>an option to add an additional gas to the plasma via an integrated MFC with a flow of 0-0.25 L/min, to enable the analysis of high-salt samples (up to 30% TDS) or organics.</li><li>an interlock drain sensor to shut down the system if a leak in the sample path is detected and to prevent samples from being lost.</li><li>an echelle polychromator that is thermostatically controlled to ensure long-term stability and reduce the need for recalibration.</li><li>a cross-dispersing prism combined with an echelle to provide a resolution of 7 pm and minimize interferences.</li><li>a random-access CID imager that provides full wavelength coverage from 167.021 to 852.145 nm.</li><li>an enhanced UV mode to allow better sensitivity and detection limits for elements between 167.021 and 240.063 nm via a second UV focused exposure.</li><li>Thermo Scientific™ <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/products/1489">Qtegra™ Intelligent Scientific Data Solution™ (ISDS) Software</a>, which provides an easy-to-navigate platform that allows the analyst to add wavelengths, create methods, analyze samples and post-process the data while the spectrometer is acquiring data.</li></ul><h4>iCAP PRO Series ICP-OES has ACT label certification</h4>Reduce your lab's environmental impact with the iCAP PRO Series ICP-OES, recipient of the ACT label from My Green Lab. The ACT Environmental Impact Factor Label is the world's premier eco-label for laboratory products. The program ensures Accountability, Consistency, and Transparency in the reporting of environmental impact data to enable sustainable laboratory procurement. It was designed by both scientists and procurement specialists to provide clear, third-party verified information about the sustainability profile of laboratory products. By providing needed transparency around manufacturing, energy and water use, packaging, and end-of-life impacts, ACT makes it easy to choose environmentally preferable products and reduce the carbon impact of laboratory supply chains.<h4>Key specifications</h4>Type: Inductively Coupled Plasma Optical Emission Spectrometer (ICP-OES) Model: iCAP PRO XPS Viewing Configuration: Duo view (axial and radial plasma observation) Spectrometer: Simultaneous echelle with 7 pm spectral bandpass at 200 nm Wavelength Range: 167–852 nm RF Source: 27 MHz, adjustable power range from 750 to 1600 W Detector Type: CID821<h5>Sample Introduction &amp; Gas Control</h5><ul><li>Standard Sampling Kit Includes:<ul><li>Concentric glass nebulizer</li><li>Glass cyclonic spray chamber</li><li>EMT Duo torch</li><li>2 mm bore quartz center tube</li></ul></li><li>Peristaltic Pump: 4-channel, 0–125 rpm</li><li>Torch Orientation: Vertical</li><li>Plasma Gas Flow: MFC tunable, 0.0–20.0 L/min</li><li>Nebulizer Gas Flow: MFC tunable, 0.0–1.5 L/min</li><li>Auxiliary Gas Flow: MFC tunable, 0.0–2.0 L/min</li><li>Purge Gas Flow: 3.4 L/min</li></ul><h5>Physical &amp; Operational Details</h5><ul><li>Dimensions (D × W × H): 690 × 615 × 933 mm</li><li>Warm-Up Time: 5 minutes from standby</li><li>Unit Size: Each</li></ul>

Thermo Scientific™ ARL™ iSpark™ Optical Emission Spectrometers

High-performance spark OES system for elemental and inclusion analysis in metals. Offers fast, precise results with advanced optics, signal processing, and automation readiness.

<h4>High-performance spark OES platform for advanced elemental and inclusion analysis in metals</h4>The ARL iSpark series is a powerful platform of optical emission spectrometers designed for fast, precise, and flexible analysis of metallic samples across the iron and steel, non-ferrous, and precious metals industries. Based on the renowned ARL PMT optical technology and equipped with state-of-the-art spark source and signal processing, the ARL iSpark offers unmatched analytical capability, long-term stability, and ease of use in routine and advanced OES workflows.<h3>Key Features and Benefits</h3><h4>🔬 Advanced PMT Optics</h4><ul><li>Legendary one-meter focal length Paschen-Runge mount</li><li>High dispersion and resolution in a compact, sealed vacuum body</li><li>Direct optical path ensures maximum sensitivity</li><li>Superior performance in multi-base and trace-level analysis</li></ul><h4>⚡ Innovative Spark Source – IntelliSource™</h4><ul><li>Controlled discharge shaping for optimal ablation and excitation</li><li>Flexible dual current control (CCS) for all metallic matrices</li><li>DISC™ (Discharge Interrupt by Short-Circuit) improves trace repeatability</li></ul><h4>🧠 Superior Signal Acquisition</h4><ul><li>Time Gated Acquisition (TGA) for ultra-precise measurement</li><li>Single Spark Acquisition (SSA) for better signal stability</li><li>DISIRE algorithm for improved precision by removing diffuse signals</li><li>FAST algorithm for selecting only optimal single spark data</li></ul><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Pragolab_Thermo_Scientific_ARL_i_Spark_OES_spektrometr_5_606072e779.jpg" alt="Thermo Scientific™ ARL™ iSpark™ Optical Emission Spectrometers" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Pragolab_Thermo_Scientific_ARL_i_Spark_OES_spektrometr_5_606072e779.jpg 202w," sizes="100vw" width="1101" height="851"><h3>Micro-Inclusion Analysis with Spark-DAT™</h3><ul><li>Rapid inclusion characterization during routine OES</li><li>Simultaneous elemental and inclusion analysis (e.g. Al₂O₃, MnS, TiB₂)</li><li>No need for surface polishing or special sample prep</li><li>Standard and advanced modes for inclusion size, type, and oxygen content</li></ul><h3>User-Friendly Design</h3><ul><li>Compact, front-access design allows wall or corner installation</li><li>Quick table changeover without tools</li><li>Air-cooled spark stand with reduced argon consumption</li><li>Smart Argon Management (SAM) with ECOmode and argon-saving presets</li></ul><h3>OXSAS Software Suite</h3><ul><li>Comprehensive instrument control, calibration, and diagnostics</li><li>Flexible user access levels and full traceability</li><li>Maintenance management and quality tools</li><li>Seamless integration with automation and SMS sample handling</li></ul><h3>Applications</h3><ul><li>Ferrous and non-ferrous metals: steel, copper, aluminum, nickel, titanium</li><li>Precious metals and specialty alloys</li><li>Inclusion analysis: cleanness control in steel/aluminum</li><li>QA/QC, production control, and R&amp;D in metallurgy and foundries</li><li>Compatible with manual or fully automated workflows</li></ul><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Pragolab_Thermo_Scientific_ARL_i_Spark_OES_spektrometr_6_fa6dd82e9f.jpg" alt="Thermo Scientific™ ARL™ iSpark™ Optical Emission Spectrometers" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Pragolab_Thermo_Scientific_ARL_i_Spark_OES_spektrometr_6_fa6dd82e9f.jpg 198w," sizes="100vw" width="938" height="738">

Thermo Scientific ARL easySpark Metal Analyzer

The ARL easySpark™ Metal Analyzer delivers fast, accurate OES analysis of solid metals from trace to percent levels. Compact, cost-effective, and easy to use—ideal for foundries and metal producers.

Perform fast, accurate and reliable elemental analysis of solid metal samples from trace to percent level with the Thermo Scientific™ ARL™ easySpark™ Metal Analyzer. This new benchtop optical emission spectrometry (OES) instrument is specially designed for foundries and metal processors who need advanced metal analysis to produce parts for automotive, aviation, aerospace, consumer products, and other industries. Easy to install, use, and maintain, the ARL easySpark analyzer is accessible to non-experts in OES who require efficiency and productivity in metal and alloy production.The ARL easySpark metal analyzer is designed to meet the challenges and demands of small-to medium-sized plants and laboratories in the metal industry that require high-quality, yet cost-effective OES analysis to produce parts for automotive, aviation, aerospace and consumer products, among other industries. The instrument features a unique multi-grating/CCD (charge-coupled device)-based optical system that delivers a high level of resolution.<h5>Additional benefits of the Thermo Scientific ARL easySpark analyzer include:</h5><ul><li>The ability to accurately analyze all elements from trace to percentage level in any solid metal sample.</li><li>Revolutionary spark source and optic design for best performance in its category.</li><li>Intuitive easy Thermo Scientific™ OXSAS &nbsp;analysis software for a fast learning curve and easy routine operations.</li><li>A robust and reliable construction that requires minimal maintenance.</li><li>Compliance with safety standards and quality regulations.&nbsp;</li><li>Simple design accessible to novice production operators and skilled laboratory staff alike.</li><li>Well suited for additional markets including metals recycling, academic and non-academic laboratories, and primary metals producers looking for an economic solution to analyze their metal products and materials for quality and process control or for a back-up instrument.</li></ul>

Products from category OES - page 2

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