Cells in the human body constantly evaluate signals from their surroundings and decide whether to divide, grow, or remain inactive. One of the key systems controlling this communication is the so-called Wnt signalling pathway. If this mechanism becomes disrupted, cells can spiral out of control, leading to uncontrolled growth and the development of tumours. Scientists from CEITEC and the Faculty of Science at Masaryk University have now described a critical decision-making process – the point at which a cell’s future development is decided. Their findings may, in the future, contribute to the search for ways to slow down or stop such processes in diseases like cancer.The Wnt signalling pathway is a mechanism that coordinates billions of cells in the body – it is responsible for the development of an entire organism from a single cell, and it continues to regulate tissue renewal throughout adult life. Until now, it was not fully understood how this mechanism works in detail. However, new research by teams from Masaryk University (MUNI) shows that the cells do not respond to stimuli smoothly, but rather operate in an on-off mode once a certain decision-threshold is crossed. This principle changes our understanding of how cells function together and helps explain situations in which cellular decision-making goes out of control and may lead to cancer development.The process begins at the surface of the cell, where a signal is captured by a receptor embedded in the cell membrane. A protein called Dishevelled (DVL) then binds to this receptor and carries the signal further into the cell. However, for the signal to continue, DVL must first undergo a series of chemical modifications. Small chemical groups begin to accumulate on its surface, progressively increasing its negative charge.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/CEITEC_Vedci_nasli_bod_zlomu_v_bunce_Prave_takto_muze_zacit_rakovina_4_7c8f80376d.jpg" alt="CEITEC/Tripsianes Lab: Scientists Uncover a Tipping Point in Cells. This Is How Cancer May Begin: New mechanism of Wnt signal transduction " srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_CEITEC_Vedci_nasli_bod_zlomu_v_bunce_Prave_takto_muze_zacit_rakovina_4_7c8f80376d.jpg 245w," sizes="100vw" width="1600" height="604">And this is where the decisive moment occurs.“We found that the DVL protein behaves like a switch – its structure changes abruptly once the negative charge on its surface exceeds a certain threshold. Only then does it rearrange and allow the signal to proceed further,” explains first author <a target="_blank" rel="noopener noreferrer" href="https://www.ceitec.eu/miroslav-micka/u92423?page=publication">Miroslav Micka</a>.At this point, DVL detaches from the receptor, allowing the signal to move deeper into the cell. The cell then receives a clear instruction on how to respond – for example, to start dividing or change its function.This crucial “tipping point,” where the fate of the signal is decided, has so far been only partially understood: “Scientists knew the pathway the signal follows, but they mostly viewed it as a gradual regulatory system. However, our teams have shown that it is rather a process based on decision points and abrupt changes once a certain threshold is crossed. This is important not only for understanding how cells function, but also for explaining what happens when these processes become dysregulated,” add corresponding authors <a target="_blank" rel="noopener noreferrer" href="https://www.ceitec.eu/konstantinos-tripsianes-ph-d/u17552?page=publication">Konstantinos Tripsianes</a> from CEITEC MUNI and <a target="_blank" rel="noopener noreferrer" href="https://www.muni.cz/en/people/11088-vitezslav-bryja">Vítězslav Bryja</a> from the Faculty of Science.Such decision points in cellular signalling are particularly important from a medical perspective, as their disruption can trigger processes that lead to tumour development. A better understanding of these processes, on the other hand, paves the way for more effective treatments.The study was published in the journal <a target="_blank" rel="noopener noreferrer" href="https://www.science.org/doi/10.1126/sciadv.aed8899">Science Advances</a>.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/CEITEC_Vedci_nasli_bod_zlomu_v_bunce_Prave_takto_muze_zacit_rakovina_2_af629ac80a.jpg" alt="CEITEC/Tripsianes Lab: Scientists Uncover a Tipping Point in Cells. This Is How Cancer May Begin: DVL in a cell (green), cell nucleus (blue)" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_CEITEC_Vedci_nasli_bod_zlomu_v_bunce_Prave_takto_muze_zacit_rakovina_2_af629ac80a.jpg 156w," sizes="100vw" width="1600" height="1600"><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/CEITEC_Vedci_nasli_bod_zlomu_v_bunce_Prave_takto_muze_zacit_rakovina_36bfbfa0c6.jpg" alt="CEITEC/Tripsianes Lab: Scientists Uncover a Tipping Point in Cells. This Is How Cancer May Begin: DVL in a cell (green), enzym modifiyng DVL (red), cell nucleus (blue)" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_CEITEC_Vedci_nasli_bod_zlomu_v_bunce_Prave_takto_muze_zacit_rakovina_36bfbfa0c6.jpg 156w," sizes="100vw" width="1600" height="1600"><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/CEITEC_Vedci_nasli_bod_zlomu_v_bunce_Prave_takto_muze_zacit_rakovina_3_f21d18e3ca.jpg" alt="CEITEC/Tripsianes Lab: Scientists Uncover a Tipping Point in Cells. This Is How Cancer May Begin: DVL in a cell (green), enzym modifiyng DVL (red), cell nucleus (blue)" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_CEITEC_Vedci_nasli_bod_zlomu_v_bunce_Prave_takto_muze_zacit_rakovina_3_f21d18e3ca.jpg 156w," sizes="100vw" width="1600" height="1600">&nbsp;<blockquote><h4>Original article</h4><h4><a target="_blank" rel="noopener noreferrer" href="https://www.science.org/doi/10.1126/sciadv.aed8899">A Wnt-induced conformational phospho-switch in DVL3 controls association with Frizzled receptors and Wnt/β-catenin signaling</a></h4>Miroslav Micka, Jitender Kumar, Petra Paclíková, Zuzana Hayek, Kateřina Hanáková, Cherine Bechara, Hana Plešingerová, Ondrej Šedo, Sara Bologna, Elise Del Nero, Kristína Gömöryová, Vojtěch Bystrý, Tomáš Gybel, Tereza Čihalová, Marek Kravec, David Potěšil, Zbyněk Zdráhal, Konstantinos Tripsianes a Vítězslav Bryja.Sci. Adv., 2026, 12(20), eaed8899<a target="_blank" rel="noopener noreferrer" href="https://doi.org/10.1126/sciadv.aed8899">DOI: 10.1126/sciadv.aed8899</a><h6>licenced under <a target="_blank" rel="noopener noreferrer" href="https://creativecommons.org/licenses/by/4.0/">CC-BY 4.0</a></h6></blockquote><h4>Abstract</h4>It is well known that Dishevelled (DVL) phosphorylation by casein kinase 1 (CK1) relays Wnt signals from Frizzled (FZD) receptors to downstream effectors, yet any mechanistic aspects of DVL function related to phosphorylation remain unresolved. Here, we uncovered a Wnt-induced DVL phospho-switch that is mutually exclusive with FZD association. CK1 multiphosphorylation changes dramatically the bulk electrostatics to promote DVL intramolecular interaction between the DEP domain and the adjacent disordered region. A panel of DVL3 mutants demonstrated a switch-like behavior at the molecular level when a charge threshold was reached. Charge accumulation proximal to DEP proved to be a key functional event required, but not sufficient, for Wnt/β-catenin signaling. Proximity interactomics revealed FZD receptors as the prominent effectors of the DVL phospho-switch function consistent with the molecular competition at the DEP interface. By integrating findings at different levels, we propose a universal mechanism, in which Wnt-induced DVL conformational phospho-switch attenuates coresidence with FZDs as a means for downstream signaling events.

 Scientists Uncover a Tipping Point in Cells. This Is How Cancer May Begin 

Time is running out to take advantage of discounted registration fees for the 19th Czech-Slovak Spectroscopic Conference (19th CSSC), one of the leading scientific events dedicated to spectroscopy and spectrometry in Central Europe. Researchers, students, instrument specialists, and industry professionals are invited to join the conference at the Faculty of Science, Palacký University Olomouc. The Early Bird registration period and the deadline for lecture and poster abstract submission both end on June 15, 2026.&nbsp;<h3>Registration</h3><blockquote>👉<a target="_blank" rel="noopener noreferrer" href="https://cssc2026.spektroskopie.cz/registration_online">Online registration form</a></blockquote><h4>Registration Fees</h4><h5>Early (before June 15, 2026)</h5><ul><li>Participant (Member of IMMSS and SSS): 10 000 CZK&nbsp;&nbsp;</li><li>Participant (Non-member of IMMSS and SSS): 14 000 CZK&nbsp;&nbsp;&nbsp;</li><li>Students: 7 000 CZK&nbsp;</li><li>1-day registration: 5 000 CZK</li><li>Accompanying person*: 5 000 CZK</li></ul><h5>Regular (after June 15, 2026)</h5><ul><li>Participant (Member of IMMSS and SSS): 13 000 CZK&nbsp;&nbsp;</li><li>Participant (Non-member of IMMSS and SSS): 18 200 CZK&nbsp;&nbsp;&nbsp;</li><li>Students: 9 100 CZK&nbsp;</li><li>1-day registration: 6 500 CZK</li><li>Accompanying person*: 6 500 CZK</li></ul>* The accompanying person does not have access to the scientific programmeThe conference fee is calculated with VAT and includes:<ul><li>attendance to lectures and poster session</li><li>book of abstracts (electronic version)</li><li>booklet</li><li>lunches, refreshments (coffee/tea breaks)</li><li>excursion</li><li>attendance at Welcome Party and Gala Dinner.&nbsp;</li></ul>For an accompanying person, the conference fee includes the Welcome Party, the excursion and the Conference Dinner. The Conference Dinner is not included in the 1-day registration. This payment should be arranged with the Organising Committee.Accommodation is not included in the conference fee.<h3>Abstract submission</h3><blockquote>👉<a target="_blank" rel="noopener noreferrer" href="https://cssc2026.spektroskopie.cz/abstract_submission_online">ABSTRACT SUBMISSION FORM</a>Deadline for lecture/poster abstract submission is June 15, 2026</blockquote><h4>Posters</h4>Prepare your poster in English in the format A0 vertically orientated (portrait). The presence of one of the authors at the poster is requested during the poster session. Materials for mounting posters will be available on the poster panels.<h4>Lectures</h4>Prepare your presentation in English in PowerPoint of Portable Document Format (pdf), both in format 16:9 (widescreen). Invited and oral lectures takes 30 and 20 minutes (including discussion), respectively.&nbsp;<h3>TOPICS &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp;&nbsp;</h3><h4>Czech - Slovak Spectroscopic Conference</h4><ul><li>Atomic spectrometry (AAS, ICP-MS, AFS, OES, speciation analysis, etc.)</li><li>Molecular spectrometry/spectroscopy (UV-Vis, NMR, IR, Raman, circular dichroism, etc.)</li><li>New techniques and data processing methods in IR and Raman spectroscopy, Special methods of Raman spectroscopy (resonance Raman, SERS, SERRS, TERS)</li><li>XRF spectrometry (EDS, WDS, XRF, PIXE, etc.)</li><li>Mass spectrometry &amp; hyphenated techniques</li><li>Instrumental radioanalytical methods (Gamma spectroscopy, NAA, etc.)</li><li>Laser spectroscopy and special spectroscopy techniques</li><li>Sample preparation and introduction techniques</li><li>Applications &nbsp;of atomic and molecular spectroscopy</li><li>Statistics and metrology in spectroscopy</li></ul><h4>Mössbauer Spectroscopy in Material Science</h4><ul><li>Environmental, catalytic, biologic, medical applications</li><li>Magnetism, magnetic nanoparticles, molecular magnets</li><li>Nanomaterials, nanostructures, nanocomposites, core-shell nanoparticles, thin films</li><li>Nanomaterials in biomedicine</li><li>Nuclear forward scattering in materials science</li><li>Solid-state chemistry and physics</li><li>Industrial applications, corrosion</li><li>Instrumentation, software</li><li>Earth Science, Mineralogy and Archaeology</li></ul><h4>Venue</h4><h5>Faculty of Science</h5><ul><li>Palacky University Olomouc</li><li>17. listopadu 1192/12, &nbsp;Olomouc, Czech Republic</li></ul>

19th CSSC 2026: Early Bird Registration and Abstract Submission Deadline Approaching

Our Library never stops expanding. What are the most recent contributions to LabRulezICPMS Library in the week of 8th June 2026? Check out new documents from the field of spectroscopy/spectrometry and related techniques!<blockquote>👉 <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/library">SEARCH THE LARGEST REPOSITORY OF DOCUMENTS ABOUT SPECTROSCOPY/SPECTROMETRY RELATED TECHNIQUES</a></blockquote><blockquote>👉 Need info about different analytical techniques? Peek into <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/library">LabRulezLCMS</a> or <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library">LabRulezGCMS</a> libraries.</blockquote>This week we bring you application notes by Agilent Technologies, Shimadzu and Thermo Fisher Scientific!<h3>1. Agilent Technologies: Fast and Reliable Analysis of Soil and Sediments using ICP-MS with an Innovative Cell</h3>High-throughput and low detection limits with the <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/library?mainauthorItems=10&amp;search=9500">Agilent 9500 ICP-QQQ</a> and a Dual-Cell System&nbsp;<ul><li>Application note</li><li><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/labrulez-bucket-strapi-h3hsga3/an_soil_sediment_9500_icp_qqq_5994_9128en_agilent_affabfb736.pdf">Full PDF for download</a></li></ul>Ever since ICP-MS instruments were first commercialized, their high sensitivity and multi-elemental capabilities have made them a suitable technique for quantifying trace elements in soil and sediment, particularly in support of environmental monitoring and regulatory compliance. To help laboratories transition to ICP-MS for these important environmental applications, the US Environmental Protection Agency (EPA) first introduced the performance-based test Method 6020 in 2007, and revised it as Method 6020B in 2014.1 Method 6020B remains widely used worldwide for the quantitative measurement of a broad range of elements, including arsenic (As), cadmium (Cd), mercury (Hg), selenium (Se), and lead (Pb), in solid and aqueous wastes by ICP-MS.&nbsp;Traditionally, single-quadrupole ICP-MS (SQ ICP-MS) instruments equipped with collision/reaction cells (CRCs) have been used to meet the requirements of Method 6020B for sample analysis. Laboratories have typically used a combination of acquisition strategies to control interferences, including no gas mode for interference-free analytes and low mass analytes, helium (He) collision mode for analytes affected by polyatomic ion interferences, and half-mass mode to correct doubly charged ion (M2+) interferences. This multi-mode approach has enabled laboratories to meet Method 6020B performance and quality control (QC) criteria over many years.&nbsp;Now, for the first time, the <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/library?mainauthorItems=10&amp;search=9500">Agilent 9500 Triple Quadrupole ICP-MS</a> featuring the Dual-Cell System (DCS) cell introduces two innovative cell gas modes, Advanced Helium Mode (AHM) and Air cell mode.2,3 These modes simplify interference removal approaches, enhance analytical performance, and accelerate analysis timesIn this study, a range of environmentally certified reference materials (CRMs) was selected to represent sample types routinely analyzed in high-throughput environmental testing laboratories. As these laboratories prioritize productivity across all aspects of their operations to remain competitive, the 9500 ICP-QQQ configuration and analytical method were optimized to maximize sample throughput. The performance of the method was evaluated according to criteria set out in Method 6020B.<h4>Conclusion&nbsp;</h4>The study has shown that the Agilent 9500 ICP-QQQ, equipped with the unique Dual-Cell System (DCS) and the optional AVS&nbsp;MS discrete sampling system, is ideal for high-throughput, multi-element analysis of soil and sediment samples.&nbsp;The use of the EPA 6020B Preset Method and selection of UHMI-4 plasma conditions in the Agilent OpenLab ICP-MS software enabled rapid setup of the instrument’s operating parameters, ensuring consistent performance across operators.&nbsp;The instrument’s matrix-tolerant plasma (low CeO/Ce ratio), UHMI, and DCS effectively addressed the challenges of analyzing high-matrix samples, including signal drift, ion suppression, and spectral interferences, thereby delivering an optimized analytical workflow.&nbsp;The method’s productivity was enhanced by operating the DCS in Advanced Helium Mode (AHM) and Air cell mode and by using short integration times, saving 5 to 10 s per sample. AHM replaces conventional no gas, helium (He) collision, and high energy He (HEHe) in a single mode, while Air cell mode uses oxygen from the laboratory, alleviating the need for gas cylinders. The 9500 maintains exceptionally high sensitivity in AHM and Air cell mode, minimizing background signals.&nbsp;Overall, the 9500 ICP-QQQ with DCS achieved excellent analytical data:&nbsp;<ul><li>Low detection limits in the low ng/L (ppt) range for most analytes.&nbsp;</li><li>Removal of M2+ interferences on Ca, As, and Se generated by Sr and rare earth elements (REEs) in the soil samples using Air cell mode.&nbsp;</li><li>Recoveries of all certified elements in the five environmental CRMs or matrix spike samples within 100 ± 10%, confirming the effective control of interferences using AHM and Air cell mode.&nbsp;</li><li>Method robustness and reproducibility over more than eight hours of continuous measurements, as demonstrated by the recoveries of ISTDs and CCVs within the limits specified in EPA Method 6020.&nbsp;</li></ul>The 9500 ICP-QQQ with DCS and an integrated AVS MS enables high-throughput, routine analysis of complex environmental matrices. The EPA Method 6020-compliant method provided accurate data by effectively handling polyatomic ion and M2+ interferences using AHM and Air cell mode.<h3>2. Shimadzu: Strength Testing of Lithium-Ion Battery Materials Using a Continuous-Testing Micro-Compression Testing Machine</h3><ul><li>Application note</li><li><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/labrulez-bucket-strapi-h3hsga3/an_01_01168_en_d2eb3ddbcb.pdf">Full PDF for download</a></li></ul><h4>User Benefits</h4><ul><li>The tests are automated, which significantly reduces the time required of the operators.</li><li>Up to 100 continuous tests can be performed.</li><li>Particle size measurement is performed by software, which reduces differences in measurement between operators</li></ul>Lithium-ion batteries have become an indispensable energy source in a wide range of fields, from everyday items like smartphones and laptops to electric vehicles and renewable energy storage systems. The batteries consist of a positive electrode, a negative electrode, an electrolyte, and a separator. Positive electrodes use transition metal oxides (e.g., lithium nickel manganese cobalt oxide [NMC]) or lithium iron phosphate (LFP) to transfer lithium, and negative electrodes generally use graphite and, recently, high-capacity materials, such as silicon. One of the issues with lithium-ion batteries is that the positive and negative electrodes are prone to cracking. This is caused by the high pressures during manufacturing, as well as during charging and discharging. This is also thought to affect their performance, such as the cycle properties. Therefore, research is being conducted on the relationship between mechanical properties and the electrochemical performance. 1), 2) This Application News presents compression tests on various battery materials as examples of quantitative evaluations of their mechanical properties. The MCT series of microcompression testing machines can perform compression testing of minute single particles. In addition, the MCT-AD model can automatically perform extraction of measurement particles, length measurements, and test operations. This results in significant time savings and enables evaluations with a larger number of measurements.<h4>MCT-AD Micro Compression Testing Machine&nbsp;</h4>Fig. 1 shows the MCT-AD and the measurement principle. The MCT compressed single particles placed on a lower compression plate using a flat indenter. Then, using data on diameters of the particles obtained in advance, a test forcedisplacement graph was created that measured various types of strength of the particles. The MCT-AD automatically performs selection of the measurement particles, length measurements, and cleaning of the indenter, which in the past had to be performed manually by the operator after each measurement. This enables continuous testing up to 100 times while consolidating the operation time by the operator and reducing labor.<h4>Conclusion&nbsp;</h4>This Application News presents a mechanical evaluation by the MCT-AD of materials used in the electrodes of lithium-ion batteries. Traditionally, this measurement process imposes a heavy workload on operators. But since the MCT-AD automatically performs extraction of measurement particles, length measurements, and test operations, there are significant labor savings, and the need for highly skilled operators is also eliminated. The MCT-AD can also handle compression testing of samples with minute particle shapes, not just battery materials, so it is useful not only for product development but also for quality control.<h3>3. Thermo Fisher Scientific: Real-time zinc-nickel coating measurements.</h3><h4>Thickness and composition analysis using the Niton XL5 Plus Handheld XRF Analyzer</h4><ul><li>Application note</li><li><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/labrulez-bucket-strapi-h3hsga3/an1685_en_12_2025_2911000_31d7d7fbe6.pdf">Full PDF for download</a></li></ul>Zinc-nickel (Zn-Ni) coatings are the result of an electroplating process that deposits a layer of zinc-nickel alloy onto the surface of a metal substrate, typically steel. Zn-Ni coatings offer superior corrosion resistance compared to pure zinc coatings and often replace cadmium coatings, as they provide comparable or better properties while complying with regulations such as REACH (Registration, Evaluation, Authorization, and Restriction of Chemicals) and RoHS (Restriction of Hazardous Substances). Commonly used in the automotive, aerospace, and electronics industries, Zn-Ni coatings are often applied to fasteners, connectors, and structural parts exposed to corrosive environments.&nbsp;Zn-Ni coatings typically consist of 85-93% zinc (Zn) and 7-15% nickel (Ni). The exact composition may vary depending on the application’s specific requirements. The coating process involves electroplating, which consists of immersing the metal substrate in an electrolyte solution containing zinc and nickel ions. An electric current is then passed through the solution, causing the zinc-nickel alloy to deposit onto the substrate. To ensure that specifications for coated parts are met, metal finishing companies must verify both the coating thickness and composition.<h4>Instrumentation&nbsp;</h4>X-ray fluorescence spectrometry (XRF) is the technology of choice for quality control of Zn-Ni plating, as it is the only analytical method that can determine the thickness and composition of the coating layer non-destructively. The use of handheld X-ray fluorescence spectrometry (HHXRF) instruments enables near-line analyses of finished products, which can be analyzed directly without being cut and brought to a separate chamber with benchtop instruments.&nbsp;In previous work [1], the <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/products/1992">Thermo Scientific™ Niton™ XL5 Plus Handheld XRF Analyzer </a>was demonstrated to be capable of measuring the coating weight or coating thickness of up to 4 layers of metal coatings on a substrate, using a proprietary standardless “fundamental parameters” algorithm. The layers and the substrate can be pure elements or alloys. Although the fundamental parameters algorithm can determine the thickness of Zn-Ni plating standardless, it delivers partial information, as the composition of the layer is not measured. To measure the composition and the thickness of the coatings simultaneously, another approach using empirical calibration can be deployed. The Niton XL5 Plus User Mode enables the operators to create their own calibration curves based on the measurements carried out on reference materials of Zn-Ni plated samples with known coating thickness and composition.<h4>Conclusion&nbsp;</h4>Performing quality control of Zn-Ni coatings is essential for metal finishers to ensure the corrosion resistance of critical parts used in the automotive and aerospace industries. The Niton XL5 Plus analyzer calibrated with user mode for this application has demonstrated its ability to deliver accurate results and numerous benefits to the metal finishing industry, including but not limited to these:&nbsp;<ul><li>Increased productivity thanks to real-time, near-line results for faster process control and reduced rework.&nbsp;</li><li>Preservation of high-value parts due to non-destructive testing that requires no cutting or damage.&nbsp;</li><li>A lower operational burden with easy deployment and low total cost of ownership.</li></ul>

News from LabRulezICPMS Library - Week 24, 2026

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Ioannes Marcus Marci Spectroscopic Society is a voluntary organization of scientific, scientific-pedagogical and professional workers in the field of spectroscopy, or legal entities engaged in scientific and application activities in this field, associated with joint activities. SSJMM was founded in 1949.

Spektroskopická společnost Jana Marka Marci

Since its establishment in 2011, CEITEC has quickly developed into a cutting-edge infrastructure for research which performs highly alongside the best institutes in Europe. Among the main priorities of CEITEC are the promotion of a motivating and dynamic international scientific environment, the provision of state-of-the-art research infrastructure, and the policy of open communication and equal opportunities.

CEITEC

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Thermo Scientific™ OXSAS™ X-Ray Fluorescence Analysis Software

Thermo Scientific™ OXSAS™ is a powerful and customizable XRF software that enables fast, template-driven analysis, automation, and standardless quantification options.

Enhance your lab efficiency and productivity with a customizable software solution that operates with XRF spectrometers. The flexible and powerful Thermo Scientific™ OXSAS™ X-ray Fluorescence Analytical Software performs rapid, high-quality sample analysis using template-driven operations.Optional standardless quantitative analysis packages offer additional versatility for labs analyzing a wide range of materials. This platform evolves to meet changing needs with up-to-date solutions throughout the instrument's lifetime.<h3>⚙️ Ease of Use</h3><ul><li>Integrated Analytical Assistant guides method creation/extension, suggesting optimal parameters for fast and accurate analysis.</li><li>Automatic Method Choice selects the best parameter set without user intervention.</li><li>Routine analysis requires minimal data-entry (e.g., just sample ID).</li><li>One-click batch creation for all samples requiring analysis.</li><li>Simple batch definition and management allows sample prioritization.</li></ul><h3>🖥️ Familiar User Interface</h3><ul><li>Comprehensive post-treatment of results, including export and Excel support.</li><li>Integrated Microsoft SQL Server Express database stores setups and data.</li><li>Export/import functions simplify transfer of standards, methods, or grades between instruments.</li><li>Regular software updates available from the OXSAS website.</li><li>Monitoring and maintenance tools help maximize system uptime.</li><li>Real-time integrated SPC (Statistical Process Control).</li><li>SCT Manager provides overview of instrument and method capability.</li><li>Measurement Uncertainty and Conformance Probability reporting for unknowns.</li></ul><h3>⚡Fast Calibration</h3><ul><li>Multiple analyte curve display, instant base curve calculation, calibration templates.</li><li>Multi-variable regression and correction models with integrated theoretical alpha calculation.</li></ul><h3>🧩 Available Options</h3>Optional standardless analysis packages for broader capability:<ul><li>Thermo Scientific™ QuantAS™ – Semi-quantitative analysis.</li><li>Thermo Scientific™ UniQuant™ – Analyze up to 79 elements in unknown samples without specific calibration, no certified reference materials needed.</li></ul><h3>🔧 Other Options</h3><ul><li>ARLcom: Result transmission via LAN/TCP/IP, serial, or to files.</li><li>Remote Sample Definition: Sample registration from external networked applications.</li><li>Automation: Supports Thermo Scientific SMS for fully automated analysis.</li><li>Charge correction: Calculates material weights needed to adjust out-of-spec charges.</li><li>SPC-Full: Full graphical package for online Statistical Process Control.</li></ul><h3>✅ Compatible with:</h3><ul><li><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/products/1211">Thermo Scientific™ ARL™ PERFORM'X Series</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/products/1212">Thermo Scientific™ ARL™ OPTIM'X Series</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/products?manufacturerItems=3&amp;search=9900">Thermo Scientific™ ARL™ 9900 IntelliPower Series</a></li></ul>

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Scientists Uncover a Tipping Point in Cells. This Is How Cancer May Begin

News from LabRulezICPMS Library - Week 24, 2026

19th CSSC 2026: Early Bird Registration and Abstract Submission Deadline Approaching