Originally developed by Dr. Hartmut Laatsch, the renowned AntiBase Library consists of more than 95,800 compounds. And with the latest release we've added over 60% more compounds!
Widely cited in scientific literature, this growing database is an effective screening tool for metabolomics and drug discovery where natural products and derivatives can accelerate treatments in for cancer, diabetes, disease, and antimicrobial or antifungal research.
Now includes Wiley’s ChemWindow software to securely search the collection, plus powerful tools build your own databases, draw structures, and more.
Wiley: AntiBase Library – Wiley Identifier of Natural Products: Overview.
Wiley is an authoritative source for scientific data. Our renowned databases are processed according to rigorous protocols to ensure they are of the highest quality. Qualification procedures start at data acquisition and continue throughout the database development process. Any data acquired from trusted partners is thoroughly vetted before inclusion in our collections.
Data is collected from primary and secondary literature; then carefully checked and validated with key references and sources provided as a data field.
In addition to chemical structures, records contain searchable metadata where available such as:
Quick access to related references for ease of use: DOI literature link, Human Metabolome Database (HMDB), ZINC, KEGG, ChEMBL
Now includes Wiley’s ChemWindow software to search the collection, plus powerful tools build your own databases, draw structures, and more.
The database includes compounds from these biological sources:
Wiley: AntiBase Library – Wiley Identifier of Natural Products: compound coverage
The Wiley Identifier of Natural Products includes and is compatible with the KnowItAll ChemWindow Edition software. It can also be used with other editions of the KnowItAll software you are using.
The AntiBase Library has been referenced over 1,500 times in Google Scholar. Here are a few of the many examples of how scientists use this database in various applications.
Summary: Streptomycetes produce bioactive natural products, including a majority of naturally produced antibiotics. Two new actinomycin analogues produced by Streptomyces sp. MBT27, actinomycin L1 and L2, have been discovered. Dereplication was performed using Reaxys, ChemSpider, and AntiBase. Mass features of existing natural products were annotated while one mass feature with an m/z value of 1387.6706 [M + H]+ could not be matched to any previously reported natural products.
Summary: Mitragyna inermis is a small tree species that grows in West Africa that has been used in traditional medicine to treat a number of conditions. Two new metabolites from this tree species have been isolated and have had their structures elucidated by comparison of their spectroscopic data with those reported in AntiBase and by DFT calculations.
Summary: To facilitate the discovery of natural products, a screening method was developed using a combination of droplet microfluidics and fluorescence-activated cell sorting-based technologies. This method was utilized to assess a microbial environmental sample. To identify the natural products, molecular formula searches were performed using AntiBase.