ASMS CONFERENCE POSTERS 2024

Importance of the Topic

The ASMS Annual Conference Poster Sessions provide a comprehensive platform for advancing mass spectrometry across analytical chemistry, drug discovery, proteomics, metabolomics, lipidomics, environmental monitoring, and imaging. These sessions bring together emerging methodologies and instrumentation, fostering knowledge exchange and collaboration among scientists, industry professionals, and regulatory agencies.

Objectives and Overview

The four-day poster program spans Monday through Thursday, with posters organized into thematic tracks. Each day features set-up, presentation for odd and even poster numbers, and removal times. Key thematic categories include:

• Ambient Ionization Applications
• Drug Discovery, DMPK, ADME
• Metabolomics and Lipidomics
• Proteomics, Single-Cell Proteomics
• Imaging Mass Spectrometry
• Environmental Chemistry and Emerging Contaminants
• Food Safety, Clinical Biomarkers, and Forensics

Methodology and Instrumentation

Poster abstracts illustrate a wide range of mass spectrometric approaches, including:

• Atmospheric pressure ionization: DART, DESI, MALDI, APCI, SIFT-MS
• Liquid chromatography–mass spectrometry: UPLC-QTOF, UHPLC-Orbitrap, HILIC, RP-LC, GC×GC-TOF
• Data acquisition methods: DDA, DIA, PASEF, TimsTOF, narrow-window DIA
• Ion mobility techniques: FAIMS, TIMS, SLIM, cyclic ion mobility
• High-throughput platforms: Evosep One, microflow LC, high-capacity micro-scaffold workflows
• Single-cell and small-sample workflows: nano-LC, microchip CE-MS, droplet microfluidics, microdroplet digestion
• Native and top-down mass spectrometry: CIDn, ETD, SID, CDMS

Main Results and Discussion

While individual poster findings vary widely, common trends emerge:

• Ambient ionization techniques are increasingly applied to biomedical and environmental analyses.
• Data‐independent acquisition and advanced search algorithms improve proteome coverage and quantitation accuracy.
• Single-cell proteomics and metabolomics workflows are achieving greater throughput and depth.
• Imaging mass spectrometry advances spatially resolved omics at cellular to tissue scales.
• Environmental monitoring focuses on PFAS, microplastics, and emerging contaminants using both targeted and non-targeted approaches.
• Clinical biomarker discovery leverages multi-omics integration for disease stratification.

Benefits and Practical Applications

This comprehensive poster program:

• Facilitates rapid method development and benchmarking for academic and industrial laboratories.
• Highlights workflows translatable to quality control, regulatory compliance, and clinical diagnostics.
• Promotes adoption of innovative technologies such as AI-driven data analysis, microfluidics, and real-time screening.

Future Trends and Applications

Key future directions include:

• Integration of ion mobility and high-resolution MS for enhanced isomer separation.
• AI and deep‐learning models for spectral interpretation, retention time prediction, and non-targeted feature annotation.
• Continued miniaturization and automation of single-cell and low-sample–volume analyses.
• Expansion of spatial multi-omics to map protein, metabolite, and lipid distributions in situ.
• Development of field-deployable, green analytical systems for environmental and clinical screening.

Conclusion

The ASMS poster sessions provide an unparalleled overview of cutting-edge mass spectrometry developments. The breadth of topics and methods presented underscores the field’s rapid evolution, driving improvements in sensitivity, throughput, and data interpretation. Attendees gain insights into emerging techniques that will shape the next generation of analytical chemistry and translational applications.

Instrumentation Used

• Direct Analysis in Real Time (DART) and Desorption Electrospray Ionization (DESI) sources
• MALDI-TOF and Sinapinic/CHCA matrices
• UPLC, HILIC, nano-LC and microflow LC systems
• GC×GC-TOF and GC–MS with thermal desorption, pyrolysis probes
• Orbitrap, Q-TOF, Q-Exactive, Triple Quadrupole and FT-ICR mass spectrometers
• trapped ion mobility (TIMS), FAIMS, SLIM and cyclic ion mobility analyzers
• Automated platforms: Evosep One, RapidFire, microchip CE-MS
• High-throughput digestion/workup: S-Trap, Filter-Aided Sample Prep, microdroplet reactors
• Native MS: charge detection MS, surface-induced dissociation, CDMS