Thermo Scientific iCAP TQs ICP-MS (PRODUCT SPECIFICATION )

Significance of the Topic

Triple quadrupole inductively coupled plasma mass spectrometry (TQ-ICP-MS) delivers unparalleled interference removal and sensitivity for ultra‐trace elemental analysis in challenging matrices such as ultra‐high purity chemicals and semiconductor materials. Simplifying its operation broadens accessibility across research, industrial QA/QC, and high‐throughput laboratories, ensuring reliable “right‐first‐time” results and faster method development.

Objectives and Overview of the Study

This product specification introduces the Thermo Scientific iCAP TQs ICP-MS system, designed to combine triple quadrupole performance with intuitive hardware and software. Key aims include reducing operational complexity, decreasing method setup time, and satisfying stringent requirements for semiconductor impurity control and UHPC analysis.

Methodology and Used Instrumentation

The iCAP TQs ICP-MS integrates:

• Sample introduction: bench‐height demountable quartz torch, Peltier‐cooled cyclonic spray chamber, concentric nebulizer, and four‐channel peristaltic pump with inert tubing.
• Collision/reaction cell (Q2): zero‐maintenance CRC with four dedicated mass flow controllers for H₂, NH₃, O₂, and He, plus support for additional gases.
• Mass analyzers: high‐frequency Q1 (4 MHz, 2–240 u) and Q3 (2 MHz, 2–290 u) quadrupoles, with user‐definable resolution and automatic calibration.
• Ion optics: 90° RAPID lens stack for high transmission and ultralow background.
• Vacuum: split‐flow turbo pump and oil‐free roots pump ensuring <1×10⁻⁶ mbar in <15 min and automatic recovery after power interruptions.
• Detection: dual‐mode electron multiplier with 100 µs dwell, linear dynamic range >10 orders of magnitude.
• Software: Qtegra Intelligent Scientific Data Solution for complete instrument and peripheral control, FDA 21 CFR Part 11 compliance, and plug‐in support for autosamplers, laser ablation, single particle analysis, organics, acid‐resistant kits, and on‐line dilution.

Main Results and Discussion

Demonstrated performance includes detection limits in the low ng·L⁻¹ to sub‐ng·L⁻¹ range for elements such as Be, In, Bi, S (as SO⁺), and P (as PO⁺), sensitivities up to 360 kcps per µg·L⁻¹, oxide ratios <3 % and Ar₂⁺ backgrounds <100 cps. Stability over 2 hours remains <3 % RSD, and isotope ratio precision is <0.1 % RSD, confirming the system’s robustness and reproducibility.

Benefits and Practical Applications of the Method

• Accurate quantitation with confidence in challenging matrices.
• Streamlined workflows and reduced training requirements.
• Rapid method development for semiconductor, UHPC, environmental, and biological samples.
• Versatile accessory integration: laser ablation, nanoparticle characterization, organics, and high‐matrix tolerance.
• Regulatory ready with electronic records and audit trails.

Future Trends and Potential Applications

Emerging directions include integration of machine‐learning for automated method optimization, expanded reaction gas chemistries for novel analytes, miniaturized and portable TQ‐ICP-MS platforms, and real‐time process monitoring in advanced manufacturing and environmental surveillance.

Conclusion

The Thermo Scientific iCAP TQs ICP-MS redefines triple quadrupole ICP-MS by combining high sensitivity, robust interference removal, and complete ease of use. Its comprehensive instrumentation and software ecosystem makes it a powerful solution for demanding trace elemental analyses across research and industry.