Thermo Scientific iCAP TQ ICP-MS (PRODUCT SPECIFICATION)

Importance of the Topic

The accurate quantification of trace elements in complex matrices is critical across environmental monitoring, pharmaceutical development, and materials science. Triple quadrupole ICP-MS technology significantly enhances interference removal, improving detection limits and ensuring high-confidence results in demanding applications.

Objectives and Overview

This document outlines the design philosophy, performance metrics, and usability features of the Thermo Scientific iCAP TQ ICP-MS. It demonstrates how the integration of innovative hardware and intuitive software reduces complexity, accelerates method development, and supports both routine and advanced research workflows.

Methodology

The iCAP TQ ICP-MS employs a three-stage quadrupole arrangement: Q1 for precursor ion selection, a Q2 collision/reaction cell for gas-phase chemistry, and Q3 for product ion analysis. Supported modes include:

• SQ mode – single quadrupole operation with optional helium collision for basic interference suppression.
• TQ on mass – reactive gases in Q2 selectively remove interferences while keeping the analyte at its native m/z.
• TQ mass shift – analyte ions react to form product ions that appear at a shifted m/z, eliminating isobaric overlaps.

The sample introduction system features a bench-height peristaltic pump, interchangeable nebulizers and spray chambers, and a demountable, self-aligning quartz torch. Qtegra ISDS software unifies instrument control, data processing, and regulatory compliance into a streamlined interface.

Used Instrumentation

Key components include:

• Sample Introduction – 12-roller peristaltic pump with inert tubing, concentric glass or PFA nebulizers, quartz or PFA spray chambers.
• Gas Control – three argon gas flow controllers with optional additional controllers for oxygen or dilution gas; four dedicated CRC gases (H₂, NH₃, O₂, He).
• Interface – front-opening nickel or platinum-tipped cones, rapid-release magnetic tool, and interchangeable inserts for high matrix or high sensitivity operation.
• Ion Optics – RAPID 90° cylindrical lens and off-axis open lens stack for maximum ion transmission and minimal maintenance.
• Mass Analyzers – Q1 and Q3 quadrupoles with user-definable resolution and automatic calibration, plus a flatapole Q2 cell.
• Detection and Vacuum – dual-mode electron multiplier detector with 100 µs dwell time and split-flow turbo pump backed by an external rotary or oil-free roots pump.
• Software – Qtegra ISDS integrates control, data evaluation, and plug-in support for autosamplers, laser ablation, speciation, and nanoparticle analysis.

Main Results and Discussion

Performance highlights include:

• Sensitivity up to 330 kcps/µg·L⁻¹ (U in SQ mode) and consistent response across all operating modes.
• Detection limits below 0.1 ng·L⁻¹ for key isotopes (In, Bi) and under 1 ng·L⁻¹ for others.
• Oxide and doubly charged ion ratios under 2% and 4%, respectively, ensuring spectral purity.
• Background counts below 1 cps at m/z 4.5 and signal stability under 3% RSD over two hours.
• Isotope ratio precision better than 0.1% RSD, supporting high-accuracy analyses.

These metrics confirm the system’s ability to deliver “right first time” data quality for diverse sample types.

Benefits and Practical Applications

• High accuracy and interference-free results boost confidence in trace element quantification.
• User-friendly design and software minimize training time and method development efforts.
• Modular peripherals enable workflows for high matrix samples, speciation studies, and single-particle characterization.
• Automated maintenance features and rapid vacuum recovery reduce instrument downtime.

Future Trends and Applications

Emerging developments may include:

• Advanced automation with robotic sample handling and online preparation.
• Integration of AI-driven data analysis for predictive interference correction.
• Expanded applications in high-throughput screening, forensic investigation, and metallomic research.
• New reaction chemistries and dynamic cell methods to address novel analytical challenges.

Conclusion

The iCAP TQ ICP-MS redefines triple quadrupole technology by merging high-performance interference removal with an operator-focused design. Its robust hardware, comprehensive software suite, and versatile accessories support both routine laboratories and advanced research, establishing a future-proof platform for elemental analysis.