PFA Inert Kit for Thermo Element2/Neptune

Importance of the Topic

The development of reliable, low-blank sample introduction systems is crucial for ultratrace elemental analysis by HR-ICP-MS and MC-ICP-MS. High sensitivity, stable signals and rapid washout are essential for diverse applications including semiconductor process chemicals, geological matrices and clinical samples.

Objectives and Overview of the Study

This technical note presents the design, fabrication and performance evaluation of the Savillex PFA inert kit for Thermo Element2 and Neptune ICP-MS instruments. The goal is to demonstrate a true double pass PFA spray chamber that matches quartz systems in sensitivity and stability while maintaining the inert properties needed for aggressive or high-matrix samples.

Methodology and Instrumentation Used

• Double pass Scott-type spray chamber machined from high-purity PFA resin (35 mm OD) with a removable inner tube held by four fins.
• Savillex C-Flow concentric PFA nebulizers (C200 used for performance testing; C50, C100 variants for microvolume or high-matrix applications).
• Semi-demountable quartz torch with O-ring sealed injector holder; injectors available in platinum or sapphire (1.8 mm ID).
• Thermo Element2 HR-ICP-MS (Pt cones) operated in normal plasma mode across low, medium and high resolution settings.
• Free aspiration sample introduction and makeup gas port integrated into an O-ring free end cap.

Main Results and Discussion

• Calibration linearity achieved down to 20 ppt for elements such as B, Na, Ca and Fe, with correlation coefficients near unity.
• Background equivalent concentrations (BECs) for 39 isotopes ranged from sub-ppt to low ppt, confirming minimal blank contribution.
• Signal stability improved by true double pass design and integrated drain guide, yielding low relative standard deviations and no signal spikes.
• Removal of droplets > 10 µm reduced plasma loading and oxide formation, enhancing plasma robustness.
• Smooth, continuous aerosol flow path and push-fit, O-ring free connectors ensured rapid washout between samples.

Benefits and Practical Applications of the Method

• Universal compatibility for inorganic, organic and high-matrix samples without hardware changes.
• Free aspiration avoids pump tubing contamination, ideal for HF-containing and aggressive organics.
• High tolerance for total dissolved solids and particulates supports geological and clinical analyses.
• Microvolume sampling capability with C35, C50, C100 or C200 nebulizers for limited-volume applications.

Future Trends and Potential Applications

The adoption of modular inert PFA systems is poised to broaden ultratrace and isotope ratio analyses in environmental monitoring, nanoparticle characterization and biomedical research. Emerging trends include further miniaturization of sample volumes, integrated multi-mode nebulization and automated wash protocols to enhance throughput and reduce carry-over.

Conclusion

Savillex’s in-house PFA inert kit combines a true double pass design with high-purity construction to deliver quartz-comparable performance in sensitivity, stability and background. Its robust, low-blank characteristics and versatile compatibility make it a valuable tool for modern ICP-MS laboratories across semiconductor, geological and clinical sectors.

Instrumentation Used

• Thermo Element2 HR-ICP-MS and Neptune MC-ICP-MS
• Savillex PFA inert kit: double pass Scott-type spray chamber, PFA tubing and injector holder
• Savillex C-Flow concentric PFA nebulizers (C200, C50 variants) in free aspiration mode
• Semi-demountable quartz torch with O-ring sealed injector interface
• Platinum and sapphire injectors (1.8 mm ID)