OneNeb Nebulizer From Agilent

Importance of the Topic

Accurate and reproducible introduction of liquid samples into plasma sources is critical for elemental analysis by ICP-OES and MP-AES. Nebulizer performance directly affects sensitivity, precision, detection limits and tolerance to complex matrices. Advances in aerosol generation can reduce downtime, broaden sample compatibility and improve data quality.

Objectives and Study Overview

This application note presents the design, operation and analytical benefits of the Agilent OneNeb nebulizer based on Flow Blurring technology. The goals are to demonstrate its enhanced sensitivity, resistance to blockage by dissolved solids, compatibility with aggressive acids and solvents, and its long-term stability relative to conventional concentric nebulizers.

Methodology and Instrumentation

The OneNeb nebulizer was evaluated on ICP-OES systems using radial and axial configurations. Solution uptake rates ranged from 0.04 to 2.0 mL/min. Performance metrics included droplet size distribution, element-specific detection limits, precision (RSD), wash-out profiles and tolerance to total dissolved solids (up to 25 % TDS).

Instrumentation Used

• Agilent OneNeb inert concentric nebulizer (PFA/PEEK construction)
• Glass cyclonic and inert spray chambers (single-pass and double-pass)
• Agilent ICP-OES spectrometers (axial and radial view)
• Standard peristaltic or micro-flow pumps for sample delivery

Key Results and Discussion

The Flow Blurring design produced an aerosol dominated by droplets <10 µm, yielding up to twofold sensitivity gains over a conventional concentric nebulizer at 1 mL/min uptake. Typical precision was <1 % RSD. Detection limits improved by 10–90 % for most elements, with highest gains observed for Cd, Cu and Na. The OneNeb tolerated high-TDS matrices without frequent blockages and showed stable response during continuous aspiration of organic solvents like ShellSol. Wash-out times for a 25 ppm Mn standard matched or exceeded those of glass nebulizers.

Benefits and Practical Applications

• Single nebulizer for routine, high-solids, acid-digest and organic samples
• Elimination of frequent instrument downtime due to clogging
• Improved detection capabilities for trace and ultra-trace analysis
• Robustness in aggressive media including HF and mixed-acid digests
• Streamlined workflows in QA/QC, petrochemical, environmental and geochemical labs

Future Trends and Potential Applications

Emerging analytical demands call for even finer aerosol control and integration with hyphenated techniques. The OneNeb platform could be adapted for micro-volume and single-cell ICP-MS, automated high-throughput screening and field-deployable plasma instruments. Further development may focus on tailored nozzle geometries and materials for specialized solvent systems.

Conclusion

The Agilent OneNeb nebulizer leverages Flow Blurring to deliver finer droplets, superior sensitivity, exceptional precision and unmatched resistance to high-TDS and aggressive solvents. Its broad compatibility and minimal maintenance requirements make it a versatile choice for modern elemental spectroscopy applications.

Reference

Agilent Application Note 5990-8340EN Evaluation of a Novel Nebulizer Using an Inductively Coupled Plasma Optical Emission Spectrometer