Agilent ICP-MS Journal (May 2022, Issue 88)

Significance of the Topic

Triple quadrupole ICP-MS (ICP-QQQ) has revolutionized elemental analysis over the past decade, providing unmatched control over spectral interferences via MS/MS modes. Concurrently, laser ablation ICP-MS (LA-ICP-MS) tuning strategies improve sensitivity and matrix tolerance for solid samples. Together with dedicated training resources and optimized maintenance products, these advances enhance data quality, laboratory efficiency, and the accessibility of ICP-MS methods across diverse fields.

Objectives and Overview

This journal issue celebrates ten years since the launch of the Agilent 8800 ICP-QQQ, summarizes expert tips for LA-ICP-MS tuning, introduces online learning paths for Agilent ICP-MS platforms, presents a specially formulated coolant for instrument reliability, and highlights a webinar and recent application notes to streamline ICP-MS workflows.

Methodology and Instrumentation

• LA-ICP-MS optimization uses NIST 61x glass SRMs to balance sensitivity and plasma robustness by monitoring oxide and U/Th ratios, adjusting helium and argon flows to achieve optimal ionization.
• ICP-MS/MS employs tandem quadrupoles Q1 and Q2 with reactive gases (e.g., NH₃, O₂) in on-mass and mass-shift modes to selectively remove or shift analyte and interfering ions.
• Instrumentation covered includes Agilent 7800/7850/7900 single quadrupole and 8800/8900 triple quadrupole ICP-MS systems, LA-ICP-MS accessories, and Agilent University eLearning platform.
• Cool Clear coolant fluid combines high-purity water and corrosion inhibitors to protect cooling circuits better than generic coolants.

Main Results and Discussion

LA-ICP-MS users optimize ThO+/Th+ and U/Th ratios to ensure plasma robustness without solvent. ICP-MS/MS demonstrations show NH₃ reaction gas removing Hg-204 interference from Pb-204 and O₂ mass-shift enabling low-level sulfur measurement at m/z 48. Over ten years, Agilent ICP-QQQ earned multiple awards and amassed over 1700 peer-reviewed publications, highlighting applications from geochemistry and nuclear analysis to life sciences and environmental monitoring. Self-paced online modules guide users through instrument setup, data processing, and troubleshooting. Comparative tests show Cool Clear prevents copper and zinc corrosion deposits in cooling manifolds. A webinar outlines Easy-fit supplies, ICP-MS MassHunter software features, and workflow tips.

Benefits and Practical Applications

• Improved detection limits for challenging elements (Si, P, S) by eliminating polyatomic and isobaric overlaps.
• Robust analysis in matrices ranging from high-salt solutions to solid samples via laser ablation.
• Enhanced user proficiency and productivity through targeted eLearning and optimized supplies.
• Minimized downtime and maintenance issues with purpose-blended coolant fluids.

Future Trends and Potential Applications

Expanding ICP-MS/MS chemistries will unlock new applications in single-cell analysis, clinical research, and advanced materials. Cloud-based training and AI-driven data interpretation tools are expected to further democratize ICP-MS technology. Continuous instrument enhancements will drive higher throughput and sensitivity.

Conclusion

Over the past decade, triple quadrupole ICP-MS and related innovations have redefined performance boundaries in elemental analysis. The integration of optimized tuning methods, tailored consumables, and comprehensive training resources empowers laboratories to achieve reliable, high-quality data with greater efficiency.

Reference

Agilent Technologies Inc. ICP-MS Journal, May 2022, Issue 88.
Application notes and technical briefs:

• ICP-MS Analysis of Trace and Major Elements in Drinking Water According to US EPA Method 200.8, 5994-4744EN
• Authenticating Geographical Origin of Tea Using ICP-MS and Agilent Mass Profiler Professional, 5994-4583EN
• Undiluted Seawater Analysis with UHMI and Discrete Sampling, 5994-4467EN
• Fast Time-Resolved Analysis of Single Cells Using ICP-MS, 5994-4460EN
• Analysis of PGEs, Ag, and Au in Roadside Dust by ICP-QQQ, 5991-6768EN
• The ICP-MS Vacuum Interface, 5994-4695EN
• Agilent I-AS Clean Autosampler, 5988-2992EN